CN104288255A - Traditional Chinese medicine preparation for treating severe acute pancreatitis - Google Patents

Traditional Chinese medicine preparation for treating severe acute pancreatitis Download PDF

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CN104288255A
CN104288255A CN201410597738.0A CN201410597738A CN104288255A CN 104288255 A CN104288255 A CN 104288255A CN 201410597738 A CN201410597738 A CN 201410597738A CN 104288255 A CN104288255 A CN 104288255A
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radix
chinese medicine
medicine preparation
acute pancreatitis
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丁灏
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/04Sulfur, selenium or tellurium; Compounds thereof
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10Carbonates; Bicarbonates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/30Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/51Gentianaceae (Gentian family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/58Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718Coptis (goldthread)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/738Rosa (rose)
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention discloses a traditional Chinese medicine preparation for treating severe acute pancreatitis. The preparation is prepared from the following raw materials in parts by weight: 10 parts of radix bupleuri, 10 parts of scutellaria root, 5-7 parts of rhizoma coptidis, 15 parts of radix paeoniae alba, 10 parts of delavay parnassia herb, 10 parts of lithospermum erythrorhizon, 10 parts of raw rhubarb, 10 parts of mirabilite powder, 5 parts of tragacanth, 15 parts of halenia elliptica, 15 parts of cortex melia azedarach, 30 parts of herba caragana microphylla, 30 parts of dahurian patrinia herb, 5 parts of calcite and 4 parts of dahurian rose fruit. Clinical experiments prove that the traditional Chinese medicine preparation, through selecting appropriate proportion of the drugs, has the efficacies of soothing liver and dispelling melancholy, and regulating qi and alleviating pain, has an extremely high cure rate in treating severe acute pancreatitis, is safe, has no toxic or side effect and can prevent related complication to achieve the purpose of treating both symptoms and root causes, so as to be worthy of clinical popularization and application.

Description

The Chinese medicine preparation for the treatment of Severe Acute Pancreatitis SAP
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for the treatment of Severe Acute Pancreatitis SAP.
Background technology
Acute pancreatitis is identified as inflammatory reaction clinically, and in recent years in the trend risen, pancreatin is activated under the initiation of relevant inducement, then makes pancreatic tissue digested, occurs the phenomenons such as hemorrhage and downright bad.Acute pancreatitis develops into Severe Acute Pancreatitis SAP when serious, and the probability of development reaches 25 %.Case fatality rate reaches 40%.Clinically to the treatment of this disease mainly based on doctor trained in Western medicine, but Western medicine side effect is large, and many patients have untoward reaction to Western medicine, and the therapeutic effect for Severe Acute Pancreatitis SAP is not remarkable.
Summary of the invention
The present invention aims to provide a kind of Chinese medicine preparation for the treatment of Severe Acute Pancreatitis SAP, it selects medical material compatibility suitable, meet Chinese medicine and modern medicine study theory, there is effect of dispersing the stagnated live-QI to relieve the stagnation of QI, regulating QI to relieve pain, high and the safe without toxic side effect for the treatment of Severe Acute Pancreatitis SAP cure rate, and related complication can be prevented to reach the object for the treatment of both the principal and secondary aspects of a disease, clinic is applied.
In order to achieve the above object, the present invention is by the following technical solutions: a kind of Chinese medicine preparation for the treatment of Severe Acute Pancreatitis SAP, is prepared from by the medical material of following weight proportion: Radix Bupleuri 9 ~ 10 parts, Radix Scutellariae 9 ~ 10 parts, Rhizoma Coptidis 5 ~ 7 parts, the Radix Paeoniae Alba 13 ~ 15 parts, Herba Parnassiae Delavayi 9 ~ 10 parts, Radix Arnebiae (Radix Lithospermi) 9 ~ 10 parts, Radix Et Rhizoma Rhei 9 ~ 10 parts, mirabilite powder 9 ~ 10 parts, tragacanth 5 ~ 8 parts, Halenia elliptica D. Don 13 ~ 15 parts, emerald green 13 ~ 15 parts, tree, littleleaf peashrub 25 ~ 30 parts, Herba Patriniae 25 ~ 30 parts, 0 ~ 5 part, calcite, Rosa bella fruit 0 ~ 4 part.
As preferably, be prepared from by the medical material of following weight proportion: Radix Bupleuri 9 ~ 10 parts, Radix Scutellariae 9 ~ 10 parts, Rhizoma Coptidis 5 ~ 7 parts, the Radix Paeoniae Alba 13 ~ 15 parts, Herba Parnassiae Delavayi 9 ~ 10 parts, Radix Arnebiae (Radix Lithospermi) 9 ~ 10 parts, Radix Et Rhizoma Rhei 9 ~ 10 parts, mirabilite powder 9 ~ 10 parts, tragacanth 5 ~ 8 parts, Halenia elliptica D. Don 13 ~ 15 parts, emerald green 13 ~ 15 parts, tree, littleleaf peashrub 25 ~ 30 parts, Herba Patriniae 25 ~ 30 parts, Rosa bella fruit 2 ~ 4 parts.
As preferably, be prepared from by the medical material of following weight proportion: Radix Bupleuri 9 ~ 10 parts, Radix Scutellariae 9 ~ 10 parts, Rhizoma Coptidis 5 ~ 7 parts, the Radix Paeoniae Alba 13 ~ 15 parts, Herba Parnassiae Delavayi 9 ~ 10 parts, Radix Arnebiae (Radix Lithospermi) 9 ~ 10 parts, Radix Et Rhizoma Rhei 9 ~ 10 parts, mirabilite powder 9 ~ 10 parts, tragacanth 5 ~ 8 parts, Halenia elliptica D. Don 13 ~ 15 parts, emerald green 13 ~ 15 parts, tree, littleleaf peashrub 25 ~ 30 parts, Herba Patriniae 25 ~ 30 parts, 3 ~ 5 parts, calcite.
As preferably, be prepared from by the medical material of following weight proportion: Radix Bupleuri 9 ~ 10 parts, Radix Scutellariae 9 ~ 10 parts, Rhizoma Coptidis 5 ~ 7 parts, the Radix Paeoniae Alba 13 ~ 15 parts, Herba Parnassiae Delavayi 9 ~ 10 parts, Radix Arnebiae (Radix Lithospermi) 9 ~ 10 parts, Radix Et Rhizoma Rhei 9 ~ 10 parts, mirabilite powder 9 ~ 10 parts, tragacanth 5 ~ 8 parts, Halenia elliptica D. Don 13 ~ 15 parts, emerald green 13 ~ 15 parts, tree, littleleaf peashrub 25 ~ 30 parts, Herba Patriniae 25 ~ 30 parts, 3 ~ 5 parts, calcite, Rosa bella fruit 2 ~ 4 parts.
As preferably, be prepared from by the medical material of following weight proportion: Radix Bupleuri 10 parts, Radix Scutellariae 10 parts, Rhizoma Coptidis 5 ~ 7 parts, the Radix Paeoniae Alba 15 parts, Herba Parnassiae Delavayi 10 parts, Radix Arnebiae (Radix Lithospermi) 10 parts, Radix Et Rhizoma Rhei 10 parts, mirabilite powder 10 parts, tragacanth 5 parts, Halenia elliptica D. Don 15 parts, emerald green 15 parts, tree, littleleaf peashrub 30 parts, Herba Patriniae 30 parts, 5 parts, calcite, Rosa bella fruit 4 parts.
A kind of preparation method for the treatment of the Chinese medicine preparation of Severe Acute Pancreatitis SAP, comprise the steps: that Radix Bupleuri, Radix Scutellariae, Rhizoma Coptidis, the Radix Paeoniae Alba, Herba Parnassiae Delavayi, Radix Arnebiae (Radix Lithospermi), Radix Et Rhizoma Rhei, Halenia elliptica D. Don, Cui Shu, littleleaf peashrub, Herba Patriniae, Rosa bella fruit are put into container by (1), add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate for subsequent use; (2) tragacanth, calcite, mirabilite powder are put into container, add strong Chinese liquor, and add a small amount of Mel, stir, through seal of vessel, water proof heating 15 ~ 25min, takes out, obtains mastic for subsequent use; (3) by the filtrate obtained by above-mentioned steps (1) ~ (2) and mastic mixing, utilize modern advanced pharmacy science and technology, make capsule, obtain the Chinese medicine preparation for the treatment of Severe Acute Pancreatitis SAP of the present invention.
The pharmacology analysis of each Chinese medicinal ingredients of the present invention is as follows:
Radix Bupleuri [nature and flavor] is bitter, is slightly cold.[return through] returns liver, gallbladder meridian.[function cures mainly] reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.
Radix Scutellariae [nature and flavor] is bitter, cold.[return through] returns lung, gallbladder, spleen, large intestine, small intestine meridian.[function cures mainly] heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Rhizoma Coptidis [nature and flavor] is bitter, cold.[return through] GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.[function cures mainly] heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle.
The Radix Paeoniae Alba [nature and flavor] is bitter, sour, is slightly cold.[return through] returns liver, spleen channel.The pain relieving of [function cures mainly] suppressing the hyperactive liver, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
The root of Herba Parnassiae Delavayi [source] liliaceous plant alertris spicata and herb.[nature and flavor] bitter in the mouth, property is cold.[function cures mainly] heat clearing away, nourishing the lung to arrest cough, promoting blood flow to regulate menstruation, parasite killing.Cure mainly cough, spitting of blood, pertussis, pants, lung abscess, acute mastitis, parotitis, amenorrhea, hypogalactia, and children's's boat amasss, ascariasis, acute toothache.
The dry root of Radix Arnebiae (Radix Lithospermi) [source] comfrey lithospermum euchromum Royle, Radix Arnebiae (Radix Lithospermi) or arnebia guttata Bunge.[function cures mainly] removing heat from blood, invigorates blood circulation, removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.
Radix Et Rhizoma Rhei [nature and flavor] is bitter, cold.[return through] returns spleen, stomach, large intestine, liver, pericardium channel.
[function cures mainly] purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.
Mirabilite powder [source] Sulfates mineral mirabilite powder race mirabilite powder, through the crystalline solid of processing and refining.[nature and flavor] are salty, bitter, cold.[return through] returns stomach, large intestine channel.[function cures mainly] purging heat to relax the bowels, moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat.
Tragacanth [nature and flavor] is sweet, flat.[return through] GUIXIN, lung, spleen, stomach warp.[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
The wounded in the battle herb that Halenia elliptica D. Don [source] is gentianaceae plant Halenia elliptica D. Don.[nature and flavor] bitter in the mouth, cold in nature.[function cures mainly] presses down association's day, and heat clearing away, cures the wound, stomach invigorating.Cure mainly association's day heat, liver-heat, plague fever, internal organs heat.[pharmacology] hepatoprotective effect.Strengthen immunologic function.Dry extract can significantly improve phagocytic percentage and the phagocytic index that mouse peritoneal engulfs thin armful, also can significantly improve the low of hydrocortisone induced mice cell immunity of spleen hemolytic activity.
Cui Shu [nature and flavor] is bitter, cold; Poisonous.[return through] returns liver, spleen, stomach warp.[function cures mainly] anthelmintic, treats tinea.For ascarid enterobiasis, abdominal pain due to worm stagnation.
Littleleaf peashrub [source] pulse family lemon chicken, with fruit medicine.[nature and flavor] are bitter, flat.[return through] returns large intestine, Liver Channel.[function cures mainly] heat-clearing and toxic substances removing, invigorates blood circulation, dispels the wind.For abdominalgia with intestinal abscess, amenorrhea dysmenorrhea, rheumatic arthralgia, tumbling and swelling.
Herba Patriniae [nature and flavor] is pungent, bitter, cool.[return through] enters stomach, large intestine, Liver Channel.[function cures mainly] heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.For acute appendicitis, lung abscess and sore and toxic, the stagnant caused breast abdomen pain of the excess-heat stasis of blood, the diseases such as the stagnant stomachache of the stasis of blood in puerperal.
The Ore of calcite [source] carbonate mineral calcite.[nature and flavor] acrid in the mouth, property is put down.[function cures mainly] heat clearing away, emesis antidiarrheal, helps digestion, removing toxic substances, and broken painful abdominal mass, nourishes, detumescence, synthetism, mediation voxel.Processed with wine calcite, gets clean calcite, pounds into fritter, puts satin on smokeless stove fire and, to white, drops in Chinese liquor, take out, dry.
The fruit of Rosa bella fruit [source] rosaceous plant Rosa bella.[nature and flavor] sweet in the mouth, puckery, property is put down.[function cures mainly] detoxifies, and invigorates blood circulation.Cure mainly Xieri Wusu Symptom disease, toxicity edema, liver-heat.[pharmacology] slow down aging.Rose hip powder can make average life and the maximum life span significant prolongation of fruit bat.Also have the effect strengthening humoral immunization simultaneously, protect the liver, antitumaous effect.
The present invention compared with prior art, has following beneficial effect:
1, Chinese medicine preparation of the present invention has effect of dispersing the stagnated live-QI to relieve the stagnation of QI, regulating QI to relieve pain, the high and safe without toxic side effect for the treatment of Severe Acute Pancreatitis SAP cure rate, and can prevent related complication.Wherein: Radix Scutellariae, Radix Bupleuri, Radix Et Rhizoma Rhei etc. have effect of heat clearing and damp drying, blood stasis dispelling removing toxic substances, can also regulate gastrointestinal function simultaneously, therefore effectively can suppress endotoxic absorption, promote the outer row of toxin.And mutually help benefit between the Rosa bella fruit selected especially, littleleaf peashrub, Radix Arnebiae (Radix Lithospermi), the evil of hundred tastes is corrected again with tragacanth, all medicines share, not only can receive the effect of dispersing the stagnated live-QI to relieve the stagnation of QI, regulating QI to relieve pain, and for prevent disease progress, in invade internal organs also have good preventive effect, very valuable on clinical application.
2, Chinese medicine preparation of the present invention selects high-quality Chinese crude drug to make, and selected medical material compatibility is suitable, meets Chinese medicine and modern medicine study theory, and utilize modern medicine pharmaceutical technology to make, safe without toxic side effect, reach the object for the treatment of both the principal and secondary aspects of a disease, clinic is applied.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Treat a Chinese medicine preparation for Severe Acute Pancreatitis SAP, the raw material composition of its effective ingredient and weight are: Radix Bupleuri 10 grams, Radix Scutellariae 10 grams, Rhizoma Coptidis 5 ~ 7 grams, the Radix Paeoniae Alba 15 grams, Herba Parnassiae Delavayi 10 grams, Radix Arnebiae (Radix Lithospermi) 10 grams, Radix Et Rhizoma Rhei 10 grams, mirabilite powder 10 grams, tragacanth 5 grams, Halenia elliptica D. Don 15 grams, emerald green 15 grams, tree, littleleaf peashrub 30 grams, Herba Patriniae 30 grams, 5 grams, calcite, Rosa bella fruit 4 grams.
Preparation method, comprise following processing step: Radix Bupleuri, Radix Scutellariae, Rhizoma Coptidis, the Radix Paeoniae Alba, Herba Parnassiae Delavayi, Radix Arnebiae (Radix Lithospermi), Radix Et Rhizoma Rhei, Halenia elliptica D. Don, Cui Shu, littleleaf peashrub, Herba Patriniae, Rosa bella fruit are put into container by (1), add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate for subsequent use; (2) tragacanth, calcite, mirabilite powder are put into container, add strong Chinese liquor, and add a small amount of Mel, stir, through seal of vessel, water proof heating 15 ~ 25min, takes out, obtains mastic for subsequent use; (3) by the filtrate obtained by above-mentioned steps (1) ~ (2) and mastic mixing, utilize modern advanced pharmacy science and technology, make capsule, obtain the Chinese medicine preparation for the treatment of Severe Acute Pancreatitis SAP of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 1, warm water delivery service after meal; Within 10 days, be 1 course for the treatment of, take 2 ~ 3 courses for the treatment of continuously.
Embodiment 2
Treat a Chinese medicine preparation for Severe Acute Pancreatitis SAP, the raw material composition of its effective ingredient and weight are: Radix Bupleuri 9 grams, Radix Scutellariae 9 grams, Rhizoma Coptidis 5 grams, the Radix Paeoniae Alba 13 grams, Herba Parnassiae Delavayi 9 grams, Radix Arnebiae (Radix Lithospermi) 9 grams, Radix Et Rhizoma Rhei 9 grams, mirabilite powder 9 grams, tragacanth 5 grams, Halenia elliptica D. Don 13 grams, emerald green 13 grams, tree, littleleaf peashrub 25 grams, Herba Patriniae 25 grams, 5 grams, calcite.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.Embodiment 3
Treat a Chinese medicine preparation for Severe Acute Pancreatitis SAP, the raw material composition of its effective ingredient and weight are: Radix Bupleuri 10 grams, Radix Scutellariae 10 grams, Rhizoma Coptidis 7 grams, the Radix Paeoniae Alba 15 grams, Herba Parnassiae Delavayi 10 grams, Radix Arnebiae (Radix Lithospermi) 10 grams, Radix Et Rhizoma Rhei 10 grams, mirabilite powder 10 grams, tragacanth 8 grams, Halenia elliptica D. Don 15 grams, emerald green 15 grams, tree, littleleaf peashrub 30 grams, Herba Patriniae 30 grams, 3 grams, calcite, Rosa bella fruit 2 grams.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
As the Chinese medicine preparation for the treatment of Severe Acute Pancreatitis SAP, selected the routine clinical observation of severe acute pancreatitis 80 in my institute's diagnosis and treatment since 2010, patient is divided into treatment group and matched group two groups at random, treatment group 40 example, matched group 40 example.The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes the Chinese medicinal capsule preparation obtained by the embodiment of the present invention 1, oral, every day 2 times, each 1 time sooner or later, each 2, warm water delivery service after meal; Within 12 days, be 1 course for the treatment of, take 1 course for the treatment of continuously, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group adopts customary medical comprehensive expectant treatment, and (1 time/4 hours, 0. lmg/ time 12 days was 1 course for the treatment of to subcutaneous injection bent skin difficult to understand.
3, efficacy determination:
(1) cure: clinical symptoms and complication all disappear, and serological index and radiographic index are also reduced to normal level.
(2) take a turn for the better: the clinical symptoms of patient and sign have obvious improvement.
(3) do not heal: the state of an illness of patient is unchanged, or have and increase the weight of.
4, result:
Select in the treatment group of the embodiment of the present invention 1 Chinese medicinal capsule, cure 36 examples, take a turn for the better 2 examples, and do not heal 2 examples, cure rate 90.0%, total effective rate 95.0%.
Cure 30 examples in matched group, take a turn for the better 4 examples, and do not heal 6 examples, cure rate 75%, total effective rate 85.0%.
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Obviously, the above embodiment of the present invention is only for example of the present invention is clearly described, and is not the restriction to embodiments of the present invention.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here cannot give exhaustive to all embodiments.Every belong to technical scheme of the present invention the apparent change of extending out or variation be still in the row of protection scope of the present invention.

Claims (6)

1. treat the Chinese medicine preparation of Severe Acute Pancreatitis SAP for one kind, it is characterized in that, be prepared from by the medical material of following weight proportion: Radix Bupleuri 9 ~ 10 parts, Radix Scutellariae 9 ~ 10 parts, Rhizoma Coptidis 5 ~ 7 parts, the Radix Paeoniae Alba 13 ~ 15 parts, Herba Parnassiae Delavayi 9 ~ 10 parts, Radix Arnebiae (Radix Lithospermi) 9 ~ 10 parts, Radix Et Rhizoma Rhei 9 ~ 10 parts, mirabilite powder 9 ~ 10 parts, tragacanth 5 ~ 8 parts, Halenia elliptica D. Don 13 ~ 15 parts, emerald green 13 ~ 15 parts, tree, littleleaf peashrub 25 ~ 30 parts, Herba Patriniae 25 ~ 30 parts, 0 ~ 5 part, calcite, Rosa bella fruit 0 ~ 4 part.
2. a kind of Chinese medicine preparation for the treatment of Severe Acute Pancreatitis SAP according to claim 1, it is characterized in that, be prepared from by the medical material of following weight proportion: Radix Bupleuri 9 ~ 10 parts, Radix Scutellariae 9 ~ 10 parts, Rhizoma Coptidis 5 ~ 7 parts, the Radix Paeoniae Alba 13 ~ 15 parts, Herba Parnassiae Delavayi 9 ~ 10 parts, Radix Arnebiae (Radix Lithospermi) 9 ~ 10 parts, Radix Et Rhizoma Rhei 9 ~ 10 parts, mirabilite powder 9 ~ 10 parts, tragacanth 5 ~ 8 parts, Halenia elliptica D. Don 13 ~ 15 parts, emerald green 13 ~ 15 parts, tree, littleleaf peashrub 25 ~ 30 parts, Herba Patriniae 25 ~ 30 parts, Rosa bella fruit 2 ~ 4 parts.
3. a kind of Chinese medicine preparation for the treatment of Severe Acute Pancreatitis SAP according to claim 1, it is characterized in that, be prepared from by the medical material of following weight proportion: Radix Bupleuri 9 ~ 10 parts, Radix Scutellariae 9 ~ 10 parts, Rhizoma Coptidis 5 ~ 7 parts, the Radix Paeoniae Alba 13 ~ 15 parts, Herba Parnassiae Delavayi 9 ~ 10 parts, Radix Arnebiae (Radix Lithospermi) 9 ~ 10 parts, Radix Et Rhizoma Rhei 9 ~ 10 parts, mirabilite powder 9 ~ 10 parts, tragacanth 5 ~ 8 parts, Halenia elliptica D. Don 13 ~ 15 parts, emerald green 13 ~ 15 parts, tree, littleleaf peashrub 25 ~ 30 parts, Herba Patriniae 25 ~ 30 parts, 3 ~ 5 parts, calcite.
4. a kind of Chinese medicine preparation for the treatment of Severe Acute Pancreatitis SAP according to claim 1, it is characterized in that, be prepared from by the medical material of following weight proportion: Radix Bupleuri 9 ~ 10 parts, Radix Scutellariae 9 ~ 10 parts, Rhizoma Coptidis 5 ~ 7 parts, the Radix Paeoniae Alba 13 ~ 15 parts, Herba Parnassiae Delavayi 9 ~ 10 parts, Radix Arnebiae (Radix Lithospermi) 9 ~ 10 parts, Radix Et Rhizoma Rhei 9 ~ 10 parts, mirabilite powder 9 ~ 10 parts, tragacanth 5 ~ 8 parts, Halenia elliptica D. Don 13 ~ 15 parts, emerald green 13 ~ 15 parts, tree, littleleaf peashrub 25 ~ 30 parts, Herba Patriniae 25 ~ 30 parts, 3 ~ 5 parts, calcite, Rosa bella fruit 2 ~ 4 parts.
5. a kind of Chinese medicine preparation for the treatment of Severe Acute Pancreatitis SAP according to claim 1, it is characterized in that, be prepared from by the medical material of following weight proportion: Radix Bupleuri 10 parts, Radix Scutellariae 10 parts, Rhizoma Coptidis 5 ~ 7 parts, the Radix Paeoniae Alba 15 parts, Herba Parnassiae Delavayi 10 parts, Radix Arnebiae (Radix Lithospermi) 10 parts, Radix Et Rhizoma Rhei 10 parts, mirabilite powder 10 parts, tragacanth 5 parts, Halenia elliptica D. Don 15 parts, emerald green 15 parts, tree, littleleaf peashrub 30 parts, Herba Patriniae 30 parts, 5 parts, calcite, Rosa bella fruit 4 parts.
6. treat the preparation method of the Chinese medicine preparation of Severe Acute Pancreatitis SAP for one kind, it is characterized in that, comprise the steps: that Radix Bupleuri, Radix Scutellariae, Rhizoma Coptidis, the Radix Paeoniae Alba, Herba Parnassiae Delavayi, Radix Arnebiae (Radix Lithospermi), Radix Et Rhizoma Rhei, Halenia elliptica D. Don, Cui Shu, littleleaf peashrub, Herba Patriniae, Rosa bella fruit are put into container by (1), add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate for subsequent use;
(2) tragacanth, calcite, mirabilite powder are put into container, add strong Chinese liquor, and add a small amount of Mel, stir, through seal of vessel, water proof heating 15 ~ 25min, takes out, obtains mastic for subsequent use;
(3) by the filtrate obtained by above-mentioned steps (1) ~ (2) and mastic mixing, utilize modern advanced pharmacy science and technology, make capsule, obtain the Chinese medicine preparation for the treatment of Severe Acute Pancreatitis SAP of the present invention.
CN201410597738.0A 2014-10-31 2014-10-31 Traditional Chinese medicine preparation for treating severe acute pancreatitis Pending CN104288255A (en)

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CN104771531A (en) * 2015-04-22 2015-07-15 蒋亚静 Traditional Chinese medicine capsule for treating prosopalgia and preparation method thereof
CN104984107A (en) * 2015-06-30 2015-10-21 卞永兴 Traditional Chinese medicine enema for treating severe acute pancreatitis
CN105832901A (en) * 2016-04-20 2016-08-10 王子娥 Traditional Chinese medicine preparation for treating acute pancreatitis and preparation method thereof

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CN101129556A (en) * 2007-08-09 2008-02-27 倪慧文 Orally taken traditional Chinese medicine for treating acute pancreatitis
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* Cited by examiner, † Cited by third party
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CN104771531A (en) * 2015-04-22 2015-07-15 蒋亚静 Traditional Chinese medicine capsule for treating prosopalgia and preparation method thereof
CN104984107A (en) * 2015-06-30 2015-10-21 卞永兴 Traditional Chinese medicine enema for treating severe acute pancreatitis
CN105832901A (en) * 2016-04-20 2016-08-10 王子娥 Traditional Chinese medicine preparation for treating acute pancreatitis and preparation method thereof

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Application publication date: 20150121