CN108186715A - A kind of Chinese medicine compound prescription for treating diabetes and preparation method thereof - Google Patents
A kind of Chinese medicine compound prescription for treating diabetes and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine compound prescriptions for treating diabetes and preparation method thereof, are related to technical field of traditional Chinese medicines, which is made of the bulk pharmaceutical chemicals of following parts by weight：9~11 parts of Asian puccoon, 9~11 parts of Radix Angelicae Sinensis, 9~11 parts of Radix Glycyrrhizae, 9~11 parts of caulis lonicerae, 4~6 parts of beeswax, 4~6 parts of borneol, 90~110 parts of sesame oil.The Chinese medicine compound prescription of the present invention has astringing to arrest bleeding, it is clearing heat and detoxicating, eliminating stasis to subdue swelling, the benefits of dispelling wind dredging collateral, erosion prevention and muscle growing, curative effect is affirmed in terms of diabetic foot ulcer is treated, and effectively alleviates the clinical symptoms of patient with diabetic feet, wound healing, operation amputation, the pain for cutting toe and the major injury that brings are avoided, and can treat other wounds and with the passing of time not be cured and all kinds of burn and scalds etc., effect is notable；The Chinese medicine compound prescription preparation method is simple simultaneously, is externally applied drug, not by oral administration, does not injure liver kidney, and detoxify anti-inflammatory, eliminating stasis to subdue swelling, erosion prevention and muscle growing significant effect have no toxic side effect.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, specially a kind of Chinese medicine compound prescription for treating diabetes and preparation method thereof.
Background technology
Diabetes are one of common chronic complicating diseases of diabetes, and incidence is constantly increasing, it has also become diabetes
One of the main reason for patient is lethal and disables.Diabetes are diabetics due to merging neuropathy and various different journeys
It spends peripheral vessel lesion and leads to lower limb infection, ulcer formation and (or) the destruction of deep tissue.Diabetic foot ulcer and gangrene
Be diabetic disable, lethal major reason, while be also the first cause of non-wound amputation.A large amount of zooperies and face
Bed research shows that diabetic foot ulcer and gangrene are that diabetic is disabled lethal major reason, in addition its treatment cycle
Long, medical expense is high, and white elephant is brought, while diabetes are also the non-wound amputation of many countries to patient and society
First cause, the research strengthened to diabetic foot is very necessary.
Diabetes belong to traditional Chinese medicine " gangrene of finger or toe ", " vessle-Bi symptom-complex ", " quenching one's thirst " scope, its etiology and pathogenesis of TCM knowledge
It is considered deficiency of both qi and yin, the turbid numbness resistance train of thought of hemostasis phlegm, and experience toxic dampness and heat and send out more.Clinically mostly using diagnosis and treatment as principle
Supplementing qi and nourishing yin, dredging collateral promoting blood circulation and removing blood stasis are method.Traditional Chinese medicine is rich and varied to the outer treating method of diabetes, clinically mostly sufficient according to suffering from
Wagner classification and tcm syndrome, determine suitable therapy.Wagner grade scales are as follows：0 grade is has generation foot to burst
The risk factor of ulcer, at present without ulcer；1 grade has ulcer for surface, and clinic is without infection；2 grades are deeper ulcer, often merge soft group
Knit inflammation, no abscess or infection of bone；3 grades are deep infection, with bone tissue lesion or abscess；4 grades are circumscribed gangrene；5 grades are
Full foot gangrene.So far, modern medicine still lacks diabetes the therapy of affirmative.
Invention content
The purpose of the present invention is to solve the deficiencies of above-mentioned technology, from clinical practice, select from plan clinical proved recipe,
There is provided that good effect, curative effect is short, cure rate is high, a kind of at low cost and Chinese medicine compound prescription for treating diabetes for having no toxic side effect is ground
Study carefully its intervention effect to diabetes, mitigate the pain on patient's body and mind, the treatment for diabetes provides experiment and clinic
Using foundation.
A kind of Chinese medicine compound prescription for treating diabetes provided by the invention, it is unique using Chinese medicine according to traditional Chinese medical theory
Pharmacological property, using Asian puccoon, Radix Angelicae Sinensis, Radix Glycyrrhizae, caulis lonicerae, beeswax, borneol and sesame oil according to certain ratio requirement and unique
Ointment is made in technique.
Chinese medicine of the present invention is prepared to be made of the bulk pharmaceutical chemicals of following parts by weight：9~11 parts of Asian puccoon, 9~11 parts of Radix Angelicae Sinensis, Radix Glycyrrhizae 9
~11 parts, 9~11 parts of caulis lonicerae, 4~6 parts of beeswax, 4~6 parts of borneol, 90~110 parts of sesame oil.
Preparation process：
S1, Asian puccoon, Radix Angelicae Sinensis, Radix Glycyrrhizae and caulis lonicerae are proportionally weighed and is mixed, by mixture at room temperature in sesame
3~4 days obtained admixing medical solutions are impregnated in oil；
S2, the admixing medical solutions heating for obtaining S1 boil 0.5~1h, are filtered, obtained using sterile gauze after natural cooling
Liquid；
S3, beeswax and borneol are weighed and is added in the liquid that S2 is obtained, ointment is obtained after stirring evenly.
Chinese medicine in the Chinese medicine compound prescription of above-mentioned diabetes：
Asian puccoon：The dry root of Boraginaceae puccoon has the effect of clearing heat and cooling blood, promoting blood circulation and detoxication, promoting eruption ecchymose removing, tool
There are resisting pathogenic microbes and apparent antigenic action, can significantly inhibit granulation tissue hyperplasia inflammation, be usually used in
Treat blood-heat and toxin exuberance, atropurpureus macula, measles without adequate eruption and sore, eczema, scald.
Radix Angelicae Sinensis：The dry root of umbelliferae angelica has the effect of replenishing and activating blood, menstruation regulating blood nourishing medicinal, relax bowel, can
Make blood progenitor cell proliferation, differentiation, blood platelet is inhibited to focus on, reduce viscosity of blood, promote the life of hemoglobin and red blood cell
Into etc., there is the anti-inflammatory effect that can be reduced capillary permeability and inhibit PGE2 synthesis or release.For the deficiency of blood it is all card,
Irregular menstruation, closed dysmenorrhea, abdominal mass knot gathers and the treatment of asthenia cold abdominalgia, arthralgia pain due to rheumatism, injury from falling down, ulcer sores etc..
Caulis lonicerae：The drying stem branch of caprifoliaceae plant honeysuckle, has effects that cleaning heat and expelling wind, removes obstruction in channels to relieve pain, contained by
Cyanidenon and galuteolin etc. there is certain anti-inflammatory analgesic to make the rat paw edema caused by bacterium infection and granulation hyperplasia
With.It is usually used in the diseases such as warm morbidity, beriberoid pyretic arthralgia and redness and swelling of joints heat pain.
Radix Glycyrrhizae：Pulse family, Glycyrrhiza perennial herb, root is sturdy with root-like stock, is a kind of help Chinese herbal medicine.Gas is micro-, sweet
It is and special.With invigorating the spleen and benefiting qi, clearing heat and detoxicating, relieving spasm to stop pain, the effect of concocting all medicines.
Borneol：Dipterocarpaceae plant kapur resin and volatile oil processed goods extraction obtain crystallization, for it is translucent seemingly
Plum blossom valve is blocky, the crystal of sheet, and off-white color to light taupe brown, gas faint scent, taste is refrigerant, has inducing resuscitation of having one's ideas straightened out, and heat-clearing is alleviated pain, and prevents
The work(of necrotic tissue and promoting muscle growing is usually used in controlling for pyreticosis coma, frightened epilepsy phlegm confusing heart, red eye, swell pain and sore swell and ache curative, burst for a long time and does not holds back, burn and scald etc.
It treats.
Beeswax：It is a kind of fatty matter being secreted by 4 pairs of wax glands of worker bee abdomen of the right age in bee colony, yellow or Huang
Brown, opaque or sub-translucent, surface is smooth, and body is light, sweet in flavor mild-natured.
Sesame oil：It is refined from sesame, there is special fragrance, color such as amber is orange micro- red, crystal clear, has and delays
Aging, protection blood vessel, relax bowel, mitigates tobacco and wine poison, protection throat, treatment rhinitis, mitigation foreign matter to the damage of esophagus with
And auxiliary treatment tracheitis and other effects.
Compared with prior art, Chinese medicine compound prescription of the invention and preparation method have the advantages that：
1st, the Chinese medicine compound prescription for the treatment of diabetes of the invention, based on the principle of TCM treatment of diabetes foot, all medicine compatibilities,
It is clearing heat and detoxicating with astringing to arrest bleeding, the benefits of eliminating stasis to subdue swelling, dispelling wind dredging collateral, erosion prevention and muscle growing, treated in terms of diabetic foot ulcer is treated
Effect affirmative, effectively alleviates the clinical symptoms of patient with diabetic feet, and wound healing avoids operation amputation, the pain for cutting toe
And the major injury brought, and other wounds can be treated with the passing of time not more and all kinds of burn and scalds etc., effect is notable.
2nd, the raw material of Chinese medicine compound prescription is simple and easy to get in the present invention, and preparation method is simple, is externally applied drug, not by oral administration, does not hinder
And liver kidney, detoxify anti-inflammatory, eliminating stasis to subdue swelling, erosion prevention and muscle growing significant effect have no toxic side effect；And dressing process is easy to operate, dressing
When and dressing after equal no pain, suitable for commercial introduction, there is good economic benefit and extensive social benefit.
Description of the drawings
Fig. 1 is that mouse foot surface of a wound photo after preceding and administration is administered in high dose diabetes Chinese medicine compound prescription group.
Specific embodiment
The present invention is described in detail below in conjunction with specific embodiment.It should be noted that in following embodiment
The homogenous quantities such as the volume of the sesame oil measured.
Embodiment 1
A kind of Chinese medicine compound prescription for treating diabetes, is prepared by following primary raw materials：Asian puccoon 45g, Radix Angelicae Sinensis 45g are sweet
Careless 45g, caulis lonicerae 45g, beeswax 20g, borneol 20g, sesame oil 450mL.
The configuration step of the Chinese medicine compound prescription is as follows：
S1, Asian puccoon, Radix Angelicae Sinensis, Radix Glycyrrhizae and caulis lonicerae are weighed respectively and is mixed, by mixture at room temperature in sesame oil
Impregnate 3 days obtained admixing medical solutions；
S2, the admixing medical solutions heating for obtaining S1 boil 0.5h, are filtered after natural cooling using sterile gauze, obtain medicine
Liquid；
S3, beeswax and borneol are weighed and is added in S2 to obtained liquid, ointment is obtained after stirring evenly.Application method：
Sore place is cleaned and is dried, this ointment is applied to affected part, it is each daily morning and evening to smear once.
Embodiment 2
A kind of Chinese medicine compound prescription for treating diabetes, is prepared by following primary raw materials：Asian puccoon 50g, Radix Angelicae Sinensis 50g are sweet
Careless 50g, caulis lonicerae 50g, beeswax 25g, borneol 25g, sesame oil 500mL.
The configuration step of the Chinese medicine compound prescription is as follows：
S1, Asian puccoon, Radix Angelicae Sinensis, Radix Glycyrrhizae and caulis lonicerae are weighed respectively and is mixed, by mixture at room temperature in sesame oil
Impregnate 3.5 days obtained admixing medical solutions；
S2, the admixing medical solutions heating for obtaining S1 boil 1h, are filtered after natural cooling using sterile gauze, obtain liquid；
S3, beeswax and borneol are weighed and is added in S2 to obtained liquid, ointment is obtained after stirring evenly.Application method：
Sore place is cleaned and is dried, this ointment is applied to affected part, it is each daily morning and evening to smear once.
Embodiment 3
The Chinese medicine compound prescription of diabetes is treated, following primary raw materials is taken to be prepared：Asian puccoon 55g, Radix Angelicae Sinensis 55g, Radix Glycyrrhizae
55g, caulis lonicerae 55g, beeswax 30g, borneol 30g, sesame oil 550mL.
The configuration step of the Chinese medicine compound prescription is as follows：
S1, Asian puccoon, Radix Angelicae Sinensis, Radix Glycyrrhizae and caulis lonicerae are weighed respectively and is mixed, by mixture at room temperature in sesame oil
Impregnate 4 days obtained admixing medical solutions；
S2, the admixing medical solutions heating for obtaining S1 boil 1h, are filtered after natural cooling using sterile gauze, obtain liquid；
S3, beeswax and borneol are weighed and is added in the liquid that S2 is obtained, ointment is obtained after stirring evenly.Application method：
Sore place is cleaned and is dried, this ointment is applied to affected part, it is each daily morning and evening to smear once.
By taking embodiment 2 as an example, carry out the present invention and tested in relation to drug effect toxicological experiment and clinical practice situation：
First, the animal experiment of a kind of Chinese medicine compound prescription for treating diabetes of the invention
The raw material that the present invention uses is herbal component, has effects that certain, no poisonous and harmful substance, thus it is given birth to
The product of production is without any side effects to human body.
Below using mouse as animal experiment object, Kunming mouse of the weight for 18~22g is selected, SPF grades, male and female are each
Half.
1st, test method：
The foundation of 1.1 diabetic mouse models：Mouse 50 is taken, randomly selects 10 as Normal group, 40 is are intended
Glycemia Decline group is matched to 40 modeling group mouse in the ratio intraperitoneal injection pH of the 150mg/kg citrate buffer solutions for being 4.2
1% streptozotocin of system carries out modeling, and streptozotocin is free of in equal volume to 10 Normal group mouse peritoneal injections
Citrate buffer solution, normally fed in 48h after injection, then fasting 12h again, then measure fasting blood sugar, fasting blood
Sugared value >=16.7mmol/L diabetes models modeling success；
The foundation of 1.2 diabetes mouse models：Using above-mentioned Normal group and the successful diabetic mice of modeling to make
Module object, using 10% chloraldurate according to 3mL/kg ratio intraperitoneal injection of anesthesia mouse, after absent corneal reflex
The nearly leg of mouse back carries out depilation processing, in the range of outer diameter 8mm, is broken with knife blade and operating scissors in same position
Local skin, exposed fascia layer.Per daily 50% glacial acetic acid scrape skin wound 1 time from next day, continuous 7 days, make wound
Ulcer causes skin ulcer surface model.
1.3 animal packets and administration：
Normal group：Streptozotocin is not injected, without diabetes, only skin ulcer modeling, next day after modeling success
In being applied with sesame oil on wound face, one time a day, continuous 7 days；
Model control group：Inject streptozotocin, Glycemia Decline, skin ulcer modeling, without using pharmaceutical intervention；
Mupirocin ointment group：Inject streptozotocin, Glycemia Decline, skin ulcer modeling, next day after modeling success
In external application mupirocin ointment on wound face, one time a day, continuous 7 days；
Low dosage diabetes Chinese medicine compound prescription group：Inject streptozotocin, Glycemia Decline, skin ulcer modeling, modeling
Next day is applied with ointment made of the Chinese medicine compound prescription in the ratio according to 0.05g/mL on wound face after success, one time a day, continuous 7
My god；
High dose diabetes Chinese medicine compound prescription group：Inject streptozotocin, Glycemia Decline, skin ulcer modeling, modeling
Next day is applied with ointment made of the Chinese medicine compound prescription in the ratio according to 0.1g/mL on wound face after success, one time a day, continuous 7
My god.
1.4 speckle full frame real time scan imagers detect：Using speckle full frame real time scan imager to pathological tissue into
Capable blood flow dynamic Imaging: Monitoring, provides dynamic monitoring curve and blood flow videograph.Mouse is carried out respectively 10% hydration
Then the anesthesia of chloral carries out the nearly leg of back and carries out depilation processing, the mouse leg fixed is put in laser speckle blood flow
Lower section proceeds by observation at imager Image Acquisition.Foot is selected to observe position, with long 3cm, the image size of wide 3cm into
Row observation, minute 3min are measured with 23 images of sample frequency/s, often choose ellipse inferior to same position
ROI is locked to be observed to facilitate.2min50s to 3min is marked after selection, with this blood flow perfusion flow of 10 seconds
Blood flow mean perfusion amount of the average value as the ROI positions of detection.
1.5 statistical method：Using SPSS17.0 statistical softwares, measurement data is represented with " mean ± standard deviation (x ± s) ",
When wherein carrying out two comparison among groups, t methods of inspection are generally used；More comparison among groups are carried out with single factor test variance method, with LSD methods point
Compare homogeneity of variance between analysis group two-by-two, but analyzed during heterogeneity of variance with Dunnett ' s methods.
2nd, result of the test：
The influence of 2.1 pairs of diabetes mouse lower limb microcirculations：Table 1 is the average blood perfusion flow data of test mice,
As it can be seen from table 1 compared with Normal group, model control group mouse lower limb blood perfusion amount is decreased obviously, and illustrates modeling
Success.Compared with model control group, low, high dose diabetes Chinese medicine compound prescription group mouse lower limb average blood perfusion flow significantly rises
Height (P<0.05 or P<0.01).Illustrate that the diabetes Chinese medicine compound prescription can improve model mice microcirculatory perfusion amount, improve micro-
Dyshaemia.
Influence of the table 1 to diabetes mouse foot microcirculation
Compared with model group*P<0.05**P<0.01
The influence of 2.2 pairs of diabetes mouse foot ulcers healings
Fig. 1 is that mouse foot surface of a wound photo after preceding and administration is administered in high dose diabetes Chinese medicine compound prescription group.Diabetes
The acra blood supply of Ulcer Models initial stage surface is normal or insufficient, local edema, skin color cyanosis, numbness, insensitive or forfeiture
Success is suppurated when the most or all of natural feet infects, necrosis, and ordinary wave and ankle-joint and shank, illustrates modeling success.It can from Fig. 1
To find out, the mouse foot wound surface after diabetes modeling festers, and diabetes focal infection has been goed deep into before administration
Musculature simultaneously causes local necrosis and muscular atrophy, then can obviously improve ulcer lesion, lesion and swelling upon administration
Degree reduces, and inflammation also gradually mitigates.Illustrate that the diabetes Chinese medicine compound prescription in the present invention can be obviously improved mouse glycosuria
Foot disease ulcer situation can shorten healing, and being capable of wound healing.
2nd, the clinical efficacy of a kind of Chinese medicine compound prescription for treating diabetes of the invention
1st, we clinically apply more, through 54 clinical observations, achieve preferable therapeutic effect.
2nd, diagnostic criteria：There is diabetes medical history, show as foot numbness, anaesthesia etc. in early days.Patient is to temperature, pain
Bitterly, the protection of pressure etc., which is felt, weakens or loses, anesthetic under the action of having the extraneous factors such as scald, foreign matter, wound
Foot ulcers will occur for foot.Occurs artery ischemia patients with type Ⅰ DM foot when serious.This kind of diabetes are caused easily by mistaken diagnosis
Consequence also most serious.Patient by hyperglycemia due to being influenced for a long time, lower limb vascular hardening, vessel wall thickening, flexibility decrease, blood
Thrombus is easily formed in pipe, and is combined into patch, causes lower limb vascular occlusion and lower limb lesion tissue.And " foot " centrifugation is dirty most
Far, ischemic phenomenon most serious, so as to cause oedema, nigrescence, rot, necrosis.
3rd, administrated method：Affected part is applied to after above-mentioned Chinese medicine compound prescription is made ointment, it is daily early, 2 times late, it smears uniformly i.e.
It can.
4th, efficacy evaluation：
It cures：Clinical symptoms completely disappear.
It improves：Clinical symptoms improve.
It is not cured：Clinical symptoms are without improvement or aggravate.
5th, therapeutic effect：Chinese medicine of the present invention treats this disease, and patient is disappeared using rear swelling, and ulcer surface heals completely or only office
Portion's swelling, ulcer surface reduce more than 30%, and effective percentage reaches 100%.
6th, model case：
6.1 Lee, man, 72 years old, peasant suffered from more than 20 years of diabetes, diabetes 2 years, and left foot ulcer gangrene, part is revealed
Bone, hospital is assert with amputation treatment of performing the operation, and is classified this disease by wagner and belongs to 5 grades, soft with diabetes Chinese medicine compound prescription of the present invention
Cream, daily medication twice, adhere to daily medication, and ulcer gangrene is fully recovered after continuous 45 days.
2nd, Liu, female, 68 years old, worker suffered from diabetes 10 years, diabetes biped ulcer 1 year, and being classified this disease by wagner belongs to
In 4 grades, with diabetes Chinese medicine compound prescription ointment of the present invention, the surface of a wound, wound healing after continuous one month are smeared twice daily.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, without departing from the principle of the present invention, several improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (2)
1. a kind of Chinese medicine compound prescription for treating diabetes, which is characterized in that be made of the bulk pharmaceutical chemicals of following parts by weight：
9~11 parts of Asian puccoon, 9~11 parts of Radix Angelicae Sinensis, 9~11 parts of Radix Glycyrrhizae, 9~11 parts of caulis lonicerae, 4~6 parts of beeswax, 4~6 parts of borneol,
90~110 parts of sesame oil.
2. the method that ointment is made in a kind of Chinese medicine compound prescription for treating diabetes according to claim 1, which is characterized in that
Include the following steps：
S1, Asian puccoon, Radix Angelicae Sinensis, Radix Glycyrrhizae and caulis lonicerae are weighed in proportion and is mixed, mixture is soaked in sesame oil at room temperature
Steep 3~4 days obtained admixing medical solutions；
S2, the admixing medical solutions heating for obtaining S1 boil 0.5~1h, are filtered after natural cooling using sterile gauze, obtain liquid；
S3, beeswax and borneol are weighed and is added in the liquid that S2 is obtained, ointment is obtained after stirring evenly.
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| CN201810240156.5A CN108186715A (en) | 2018-03-22 | 2018-03-22 | A kind of Chinese medicine compound prescription for treating diabetes and preparation method thereof |
| CN201910063430.0A CN109481495A (en) | 2018-03-22 | 2019-01-23 | A kind of Chinese medicine compound prescription and preparation method thereof for treating diabetes |
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| CN110787178A (en) * | 2019-12-05 | 2020-02-14 | 上海健康医学院 | Medical application of luteoloside |
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|---|---|---|---|---|
| CN102441020A (en) * | 2010-10-08 | 2012-05-09 | 何晓磊 | Preparation method of compound radix arnebiae oil |
| CN104706713B (en) * | 2015-02-13 | 2019-05-14 | 常柏 | A kind of Chinese medicine composition and preparation method thereof for treating diabetic ulcer |
| CN105381051A (en) * | 2015-12-10 | 2016-03-09 | 袁明东 | Traditional Chinese medicinal combined medicine for treating non-amputation long-term disunion of diabetic foot and preparation method of traditional Chinese medicinal combined medicine |
-
2018
- 2018-03-22 CN CN201810240156.5A patent/CN108186715A/en not_active Withdrawn
-
2019
- 2019-01-23 CN CN201910063430.0A patent/CN109481495A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110787178A (en) * | 2019-12-05 | 2020-02-14 | 上海健康医学院 | Medical application of luteoloside |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109481495A (en) | 2019-03-19 |
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