CN109529022A - A kind of diabetic foot wound externally applied drug and its application method - Google Patents

A kind of diabetic foot wound externally applied drug and its application method Download PDF

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Publication number
CN109529022A
CN109529022A CN201910014889.1A CN201910014889A CN109529022A CN 109529022 A CN109529022 A CN 109529022A CN 201910014889 A CN201910014889 A CN 201910014889A CN 109529022 A CN109529022 A CN 109529022A
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parts
chinese medicine
externally applied
medicine composition
applied drug
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郭方
严汀华
刘毅
陈峻崧
江金华
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Jiangsu Meideyu Medical Technology Co Ltd
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Jiangsu Meideyu Medical Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H33/00—Bathing devices for special therapeutic or hygienic purposes
    • A61H33/14—Devices for gas baths with ozone, hydrogen, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H35/00—Baths for specific parts of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/28—Mercury; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/38—Silver; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H33/00—Bathing devices for special therapeutic or hygienic purposes
    • A61H33/14—Devices for gas baths with ozone, hydrogen, or the like
    • A61H2033/143—Devices for gas baths with ozone, hydrogen, or the like with oxygen

Abstract

The present invention relates to a kind of diabetic foot wound externally applied drug and its application methods, are related to diabetes medication field.Specific externally applied drug includes Chinese medicine composition decoction liquor, insulin, growth factor and Nano silver solution.Chinese medicine includes the component of following parts by weight: 10-12 parts of radices trichosanthis, 10-12 parts of sweet wormwood, 8-10 parts of Radix Angelicae Sinensis, 10-15 parts of peach kernel, 10-12 parts of safflower, 10-15 parts of dandelion, 5-8 parts of olibanum, 10-12 parts of myrrh, 3-5 parts of calomel mercurous chloride, 8-10 parts of litharge and 10-12 parts of borneol.It aims to solve the problem that impaired wound healing in existing treatment means, needs the problem for the treatment of for a long time.The beneficial effect of present specification is that selection Chinese medicine composition decoction liquor, insulin, growth factor and Nano silver solution match, and from the inside to the outside, not only acts as the effect for the treatment of, and also have facilitation for the recovery of the surface of a wound after the completion for the treatment of.

Description

A kind of diabetic foot wound externally applied drug and its application method
Technical field
The present invention relates to diabetes drug field more particularly to a kind of diabetic foot wound externally applied drugs and its use Method.
Background technique
WHO is by diabetes is defined as: diabetic is due to merging neuropathy and various different degrees of peripheral bloods Pipe lesion and the destruction for leading to lower limb infection, ulcer and/or deep tissue.Diabetes are also known as diabetic acromelic gangrene, are sugar The sick common and serious complication of urine, has very high crippling and lethal.
Authorization Notice No. is that the Chinese patent of CN103735839B discloses a kind of external traditional Chinese medicinal application for treating diabetes. Specific Chinese medicine selection pierces old duck, rhizoma polygonati, riparian greenbrier root and rhizome, flower and turns and rise root, japanese snailseed root, littleleaf willow root and leaf, three tinkling of pieces of jade, marginate rockbell herb, uses When grind into powder, be tuned into paste with physiological saline, spread on the surface of a wound.By clinical observation, total effective rate reaches 93.3%.
Traditional Chinese medicine viewpoint thinks that diabetes, which start from, quenches one's thirst, and empty derived from system element, imbalance of yin and yang, deficiency of Yin fire toxin is flourishing, heat Burn saliva blood, blood is not normal, become silted up resistance lower limb sering, become silted up resistance with the passing of time, train of thought occlusion, muscles and bones skin and flesh lose qi and blood honor support, heat corruption at Purulence, so as to cause necrosis.
So above-mentioned external traditional Chinese medicinal application is selected to be treated, drug effect is enabled to directly act on diabetes local disease Stove, drug guide drugs to illness station, and are obviously shortened the time of the symptoms such as topical ulcers, suppuration, rotten.But practical Chinese medicine when in use Although the effect of external application enables to therapeutic effect improvement and therapeutic effect is safer, but treats slow impaired wound healing, needs It to treat for a long time, so bring discomfort to patient.
Summary of the invention
The purpose of the present invention is to provide a kind of diabetic foot wound externally applied drugs, have therapeutic effect good, treatment time Short advantage.
Above-mentioned purpose of the invention has the technical scheme that
A kind of diabetic foot wound externally applied drug, including Chinese medicine composition decoction liquor, insulin, growth factor and nano silver are molten Liquid.
Implement above-mentioned technical proposal, Chinese medicine composition decoction liquor is selected big as far as possible can to bring drug effect into play；Pancreas islet The addition of element can accelerate utilization of the tissue to glucose, improve microcirculation, and local topical can destroy bacteria live environment, promote ammonia Base acid enters intracellular activation, accelerates protein synthesis, to accelerate wound repair；The growth factor of addition equally can speed up Wound healing；Nano silver solution has broad-spectrum bactericidal action, moreover it is possible to play repair, clinical test to impaired epithelial cell In, enable to therapeutic effect relatively good when several drugs are combined together use, treatment speed is than very fast.
Further, the Chinese medicine of the Chinese medicine composition decoction liquor includes the component of following parts by weight: radices trichosanthis 10-12 Part, 10-15 parts of dandelion, 5-8 parts of olibanum, does not have 10-12 parts of sweet wormwood, 8-10 parts of Radix Angelicae Sinensis, 10-15 parts of peach kernel, 10-12 parts of safflower 10-12 parts of medicine, 3-5 parts of calomel mercurous chloride, 8-10 parts of litharge and 10-12 parts of borneol.
Implement above-mentioned technical proposal, radices trichosanthis has the function and effect of clearing heat-fire removing toxic substances, and detumescence and apocenosis treats the surface of a wound.
Sweet wormwood breaks for sore and does not close up long.
Radix Angelicae Sinensis, it is sweet in flavor, pungent, bitter, it is warm-natured, return liver, the heart, the spleen channel, replenishing and activating blood, menstruction regulating and pain relieving cures mainly ulcer sore wound.
Peach kernel: have and go extravasated blood, anti-inflammatory, antianaphylactic function and effect.
Safflower: help to treat traumatic injury, sore swell and ache curative, activating microcirculation and removing stasis medicinal, the function and effect of dissipate wet effect going to swell.
Dandelion: it is bitter, it is sweet, it is mainly used for treating sore swells pain.
Olibanum: promoting blood circulation and stopping pain.The swelling and pain of sore subcutaneous ulcer；Externally used detumescence myogenic.
Myrrh: it is bitter, it is pungent, flat, return liver, spleen, the heart, kidney channel dissipate blood detumescence, analgesic therapy myogenic.
Calomel mercurous chloride: external application desinsection attacks poison, sore.
Litharge: eliminating dampness, desinsection, sore.It breaks for sore and does not close up long.
Borneol: cooperation traditional Chinese medicinal components cause the discomfort of patient using reducing in use.
Above traditional Chinese medicinal components, which are used in conjunction with each other, to treat the surface of a wound from the inside to the outside, and therapeutic effect is good.
Further, the Chinese medicine of the Chinese medicine composition decoction liquor includes the component of following parts by weight: 10 parts of radices trichosanthis, blueness 12 parts of wormwood artemisia, 10 parts of Radix Angelicae Sinensis, 15 parts of peach kernel, 10 parts of safflower, 15 parts of dandelion, 8 parts of olibanum, 12 parts of myrrh, 4 parts of calomel mercurous chloride, litharge 10 parts and 12 parts of borneol.
Implement above-mentioned technical proposal, specific traditional Chinese medicinal components select above-mentioned constituent content that can obtain good treatment effect Fruit.
Further, the decocting method of the Chinese medicine composition decoction liquor comprises the following steps that
Step 1: the water that 5-8 times of Chinese medicine composition weight is added decocts 20-30min, filters out medical fluid liquid, obtains the first medical fluid；
Step 2: the addition of the first medical fluid is mixed after continuously adding the water decoction 15-20min of 2-3 times of Chinese medicine composition weight, after It is continuous to decoct 2-5min, medical fluid is filtered out, Chinese medicine composition decoction liquor is obtained.
Implement above-mentioned technical proposal, the decoction step of Chinese medicine is consistent with traditional decoction step, and the operation of realization is simpler Folk prescription just, facilitates oneself daily external application of patient.
Further, the topically effective amount of the insulin is 0.5-0.6U/cm2, the topically effective amount of the growth factor For 0.5 μ g/10cm2。
Implement above-mentioned technical proposal, clinical trial selects the dosage of insulin and growth factor within the above range, real Existing therapeutic effect is good.
Further, the mass fraction of the nano silver is 5ppm.
Implement above-mentioned technical proposal, nano silver when in use, plays antibacterial function and effect, and concentration 5ppm its For function and effect with regard to obvious, using effect is good.
Another goal of the invention of the invention is to provide a kind of application method of diabetic foot wound externally applied drug, utilizes this Method can further enhance therapeutic effect.
A kind of application method of diabetic foot wound externally applied drug, which is characterized in that include the following steps,
S1: the cleaning surface of a wound；S2: Chinese medicine composition decoction liquor, insulin, growth factor and Nano silver solution are passed through into foot trauma Therapeutic equipment imposes on patient skin surface；
S3: seance is completed.
Implement above-mentioned technical proposal, the surface of a wound cooperates the drug of sterilization debridement during cleaning, so that the surface of a wound keeps dry Only, then foot sore is cooperated to hurt therapeutic equipment use, it is more excellent compared with the therapeutic effect for being directly applied with realization.
Further, the foot trauma therapeutic equipment includes protection shell, is fixedly connected with treatment on the protection shell Case is provided with oxygenerator and ultrasonic atomizer in the protective shell body, treats and is provided with treatment chamber on case and controls for closing The sealing element for treating chamber, in being provided with sterile film in the treatment chamber, oxygenerator be set to protective shell body it is interior and with the nothing Mycoderm is connected to by oxygen cathete, and ultrasonic atomizer is set in protective shell body and is connected to the sterile film by grug transportation tube, institute It states and offers taking mouth on treatment case, kit is slidably connected on ultrasonic atomizer, screening is slidably connected in the taking mouth Baffle is provided with the second connector connected for the first connector of oxygen cathete connection with for grug transportation tube, institute on the sterile film State the shaping ring being provided at the first connector and the second connector for oxygen cathete and grug transportation tube installation.
Implement above-mentioned technical proposal, wound externally applied drug can form small droplets particles by ultrasonic atomizer during treatment It is smaller, it is more easier to absorb at the surface of a wound, and oxygen can be delivered in treatment chamber by oxygen supply device, with drug in treatment chamber The increase of droplet and oxygen enables to drug is as much as possible to be absorbed by the surface of a wound, and effect is absorbed good, and the process for the treatment of is just It can be shortened, improve the treatment experience of patient.The setting of sterile film can be put into for the foot of patient, avoid different types of trouble Cross-infection between person.
Further, the sealing element includes the first sealing plate being hinged on the treatment case, to be provided with described first close The first aperture on sealing plate, the second sealing plate being hinged on the treatment case, be provided on second sealing plate second Aperture, first aperture and the second aperture split form the receiving hole for accommodating patient legs.
Implement above-mentioned technical proposal, when patient treats, the first sealing plate and the second sealing plate are opened, then will Foot is put into therapeutic room, then closes the first sealing plate and the second sealing plate lid, and the inner wall of receiving hole is contradicted in leg, so that It treats and is in a more closed state in chamber, to reduce the entrance of outer germs.
Further, the application method of the diabetic foot wound externally applied drug, includes the following steps,
S1: the cleaning surface of a wound；
S2: Chinese medicine composition decoction liquor, insulin, growth factor and Nano silver solution are put in kit, patient stretches foot Enter to the treatment indoor sterile film of chamber, oxygenerator conveys oxygen and is atomized vulneraia to chamber, ultrasonic atomizer is treated and conveys It is contacted in treatment chamber with the surface of a wound；
S3: foot is taken out treatment chamber and completes treatment by treatment end, continual cure 15-20min after conveying to vulneraia.
Implement above-mentioned technical proposal, drug formation droplet shape is delivered at the surface of a wound, the good absorbing at the surface of a wound reduces Liniment is contacted with the surface of a wound, the secondary insult of formation, and can be done directly treatment using equipment, reduces external application dressing Program, it is easy to operate.
In conclusion the invention has the following advantages:
One, foot trauma externally applied drug selection Chinese medicine composition decoction liquor, insulin, growth factor and Nano silver solution match, From the inside to the outside, the effect for the treatment of is not only acted as, and also relatively good for the recovery of the surface of a wound after the completion for the treatment of；
Two, for traditional Chinese medicinal components in selection, same cooperate upon completion of the treatment also can be than very fast for surface of a wound recovery；
Three, foot trauma externally applied drug during use, by the pressurization of drug droplet cooperation oxygen, increases the suction of drug It receives, therapeutic effect is more preferably.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the foot trauma therapeutic equipment of the embodiment of the present invention one；
Fig. 2 is the structural schematic diagram of the protection shell and oxygenerator of the foot trauma therapeutic equipment of the embodiment of the present invention one；
Fig. 3 is the structure chart of the treatment chamber and oxygen cathete of the embodiment of the present invention one；
Fig. 4 is the ultrasonic atomizer of the embodiment of the present invention one and the structure chart of kit；
Fig. 5 is the first sealing plate of embodiment one and the structure chart of the first sealing plate.
Appended drawing reference: 1, shell is protected；11, case is treated；111, sterile film；1112, shaping ring；112, taking mouth；113, Shutter；114, the first sealing plate；1141, the first aperture；115, the second sealing plate；1151, the second aperture；116, kit； 117, chamber is treated；12, oxygenerator；121, oxygen cathete；13, ultrasonic atomizer；131, grug transportation tube；141, slider bar；142, sliding Dynamic slot；15, fixed ring.
Specific embodiment
Below in conjunction with attached drawing, the technical solution of the embodiment of the present invention is described.
Embodiment one
Diabetic foot wound externally applied drug, including Chinese medicine composition decoction liquor, insulin, growth factor and Nano silver solution.Pancreas Local application's amount of island element is 0.5U/cm2, and local application's amount of growth factor is 0.5 μ g/10cm2, the mass fraction of nano silver For 5ppm, usage amount 5g.
The Chinese medicine of Chinese medicine composition decoction liquor includes the component of following weight: radices trichosanthis 10g, sweet wormwood 12g, Radix Angelicae Sinensis 12g, peach Benevolence 10g, safflower 12g, dandelion 10g, olibanum 5g, myrrh 10g, calomel mercurous chloride 3g, litharge 10g and borneol 12g.
The decocting method of Chinese medicine composition decoction liquor comprises the following steps that
Step 1: the water that 530g is added decocts 20min, filters out medical fluid, obtains the first medical fluid；
Step 2: the addition of the first medical fluid being mixed after continuously adding the water decoction 15min of Chinese medicine composition weight 318g, continues to decoct 2min is boiled, medical fluid is filtered out, obtains Chinese medicine composition decoction liquor.
The application method of diabetic foot wound externally applied drug, includes the following steps,
S1: the cleaning surface of a wound, the surface of a wound are first cleaned with 0.9% sodium chloride injection, after the Iodophor cleaning surface of a wound with 1%, then with 0.9% sodium chloride injection is thorough；
S2: Chinese medicine composition decoction liquor, insulin, growth factor and Nano silver solution are imposed on by foot trauma therapeutic equipment Patient skin surface；
S3: seance is completed, continual cure 15min after conveying to vulneraia, and foot is taken out the treatment completion of chamber 117 and is controlled It treats.
Specifically, as illustrated in fig. 1 and 2, foot trauma therapeutic equipment includes protection shell 1, protects and be fixedly connected on shell 1 There is treatment case 11, protect and be provided with oxygenerator 12 and ultrasonic atomizer 13 (referring to fig. 2 and Fig. 5) in shell 1, treats and set on case 11 It is equipped with treatment chamber 117 and the sealing element for closed treating chamber 117, is provided with sterile film 111 in treating in chamber 117 (referring to fig. 4), oxygenerator 12 be set in protection shell 1 and be connected to sterile film 111 by oxygen cathete 121 (referring to fig. 2 and 3), ultrasonic atomizer 13 is set in protection shell 1 and is connected to (referring to fig. 4) with sterile film 111 by grug transportation tube 131.
As shown in figure 4, sterile film 111 can be by being arranged fixed ring 15 in treatment 117 side wall of chamber, by nothing when fixed Mycoderm set 111 is tightened in fixed ring 15 by rubber band.
As shown in Figures 4 and 5, it treats on case 11 and offers taking mouth 112, slidably connect kit on ultrasonic atomizer 13 116, sliding kit 116 stretches out taking mouth 112 to add drug, and shutter 113 is slidably connected in taking mouth 112.It blocks Plate 113 can be connected by sliding part, and specific sliding part includes slider bar 141, sliding groove 142, and slider bar 141, which is fixedly connected on, to be taken The two sides of object mouth 112, sliding groove 142 are provided on the side wall of the mutual direction of slider bar 141, and shutter 113 is sliding along sliding groove 142 It moves.
As shown in Fig. 4 Lakers 5, it is provided on sterile film 111 for the first connector of the connection of oxygen cathete 121 and for grug transportation tube Second connectors of 131 connections are provided at the first connector and the second connector for oxygen cathete 121 and the peace of grug transportation tube 131 The shaping ring 1112 of dress.Oxygen cathete 121 is plugged at the first connector, and grug transportation tube 131 plugs at the second connector again, shaping ring 1112 be set as elastic rubber material, oxygen cathete 121 and grug transportation tube 131 close to one end of sterile film 111 be hard plastic tube material, Oxygen cathete 121 and grug transportation tube 131, which are inserted into shaping ring 1112, completes installation.Oxygen cathete 121 and grug transportation tube 131 divide when actual installation Not Dui Zhun a foot, and the height of oxygen cathete 121 higher than grug transportation tube 131 install.
As shown in figure 4, sealing element includes the first sealing plate 114 being hinged on treatment case 11, is provided with the first sealing plate The first aperture 1141 on 114, the second sealing plate 115 being hinged on treatment case 11, be provided on the second sealing plate 115 the Two apertures 1151, the first aperture 1141 and 1151 split of the second aperture form the receiving hole for accommodating patient legs.Hold It receives hole and patient legs joint place is provided with sealing rubber strip.
The application method of specific foot trauma therapeutic equipment are as follows: foot is extend into the sterile film in treatment chamber 117 by patient In 111, then the first sealing plate 114 and the second sealing plate 115 lid are closed, the leg of receiving hole and patient contradict at this time, thus Make to treat the state in a sealing in chamber 117, medical staff starts oxygenerator 12 and ultrasonic atomizer 13, oxygen processed at this time Machine 12 generates the oxygen that concentration is 90%-98%, and oxygen is delivered in treatment chamber 117 by delivery pipe.Ultrasonic atomizer 13 Medicament is atomized, and is delivered in treatment chamber 117.Since the height of oxygen cathete 121 is greater than the height of grug transportation tube 131, thus So that oxygen and medicament preferably form circulation in treatment chamber 117 so that patient feet it is comprehensive receive medicament, simultaneously The treatment chamber 117 of sealing forms high pressure after input oxygen and medicament so that the assimilation effect of medicament and wound more Effect is closed to get a promotion.
After terminating treatment, patient opens the first sealing plate 114 and the second sealing plate 115, by foot together with sterile film 111 It rises and takes out.
Embodiment two
The difference of embodiment two and embodiment one is dosage, machined parameters and the treatment parameter of foot trauma externally applied drug not Together.
Diabetic foot wound externally applied drug, including Chinese medicine composition decoction liquor, insulin, growth factor and nano silver are molten Liquid.Local application's amount of insulin is 0.5U/cm2, local application's amount of growth factor is 0.5 μ g/10cm2, the quality of nano silver Score is 5ppm, usage amount 5g.
The Chinese medicine of Chinese medicine composition decoction liquor includes the component of following weight: radices trichosanthis 11g, sweet wormwood 11g, Radix Angelicae Sinensis 12g, peach Benevolence 11g, safflower 11g, dandelion 10g, olibanum 6g, myrrh 10g, calomel mercurous chloride 4g, litharge 10g and borneol 12g.
The decocting method of Chinese medicine composition decoction liquor comprises the following steps that
Step 1: the water that 648g is added decocts 20min, filters out medical fluid, obtains the first medical fluid；
Step 2: the addition of the first medical fluid being mixed after continuously adding the water decoction 15min of Chinese medicine composition weight 324g, continues to decoct 2min is boiled, medical fluid is filtered out, obtains Chinese medicine composition decoction liquor.
The application method of diabetic foot wound externally applied drug, includes the following steps,
S1: the cleaning surface of a wound, the surface of a wound are first cleaned with 0.9% sodium chloride injection, after the Iodophor cleaning surface of a wound with 1%, then with 0.9% sodium chloride injection is thorough；
S2: Chinese medicine composition decoction liquor, insulin, growth factor and Nano silver solution are imposed on by foot trauma therapeutic equipment Patient skin surface；
S3: seance is completed, continual cure 15min after conveying to vulneraia, and foot is taken out the treatment completion of chamber 117 and is controlled It treats.
Embodiment three
Diabetic foot wound externally applied drug, including Chinese medicine composition decoction liquor, insulin, growth factor and Nano silver solution.Pancreas Local application's amount of island element is 0.6U/cm2, local application's amount of growth factor is 0.6 μ g/10cm2, the mass fraction of nano silver For 5ppm, usage amount 5g.
The Chinese medicine of Chinese medicine composition decoction liquor includes the component of following weight: radices trichosanthis 12g, sweet wormwood 11g, Radix Angelicae Sinensis 11g, peach Benevolence 12g, safflower 11g, dandelion 12g, olibanum 7g, myrrh 11g, calomel mercurous chloride 5g, litharge 8g and borneol 11g.
The decocting method of Chinese medicine composition decoction liquor comprises the following steps that
Step 1: the water that 777g is added decocts 25min, filters out medical fluid, obtains the first medical fluid；
Step 2: the addition of the first medical fluid being mixed after continuously adding the water decoction 18min of Chinese medicine composition weight 222g, continues to decoct 3min is boiled, medical fluid is filtered out, obtains Chinese medicine composition decoction liquor.
The application method of diabetic foot wound externally applied drug, includes the following steps,
S1: the cleaning surface of a wound, the surface of a wound are first cleaned with 0.9% sodium chloride injection, after the Iodophor cleaning surface of a wound with 1%, then with 0.9% sodium chloride injection is thorough；
S2: Chinese medicine composition decoction liquor, insulin, growth factor and Nano silver solution are imposed on by foot trauma therapeutic equipment Patient skin surface；
S3: seance is completed, continual cure 18min after conveying to vulneraia, and foot is taken out the treatment completion of chamber 117 and is controlled It treats.
Example IV
Diabetic foot wound externally applied drug, including Chinese medicine composition decoction liquor, insulin, growth factor and Nano silver solution.Pancreas Local application's amount of island element is 0.6U/cm2, local application's amount of growth factor is 0.6 μ g/10cm2, the mass fraction of nano silver For 5ppm, usage amount 5g.
The Chinese medicine of Chinese medicine composition decoction liquor includes the component of following weight: radices trichosanthis 12g, sweet wormwood 10g, Radix Angelicae Sinensis 10g, peach Benevolence 13g, safflower 10g, dandelion 13g, olibanum 7g, myrrh 11g, calomel mercurous chloride 5g, litharge 9g and borneol 10g.
The decocting method of Chinese medicine composition decoction liquor comprises the following steps that
Step 1: the water that 880g is added decocts 28min, filters out medical fluid, obtains the first medical fluid；
Step 2: the addition of the first medical fluid being mixed after continuously adding the water decoction 18min of Chinese medicine composition weight 220g, continues to decoct 4min is boiled, medical fluid is filtered out, obtains Chinese medicine composition decoction liquor.
The application method of diabetic foot wound externally applied drug, includes the following steps,
S1: the cleaning surface of a wound, the surface of a wound are first cleaned with 0.9% sodium chloride injection, after the Iodophor cleaning surface of a wound with 1%, then with 0.9% sodium chloride injection is thorough；
S2: Chinese medicine composition decoction liquor, insulin, growth factor and Nano silver solution are imposed on by foot trauma therapeutic equipment Patient skin surface；
S3: seance is completed, continual cure 18min after conveying to vulneraia, and foot is taken out the treatment completion of chamber 117 and is controlled It treats.
Embodiment five
Diabetic foot wound externally applied drug, including Chinese medicine composition decoction liquor, insulin, growth factor and Nano silver solution.Pancreas Local application's amount of island element is 0.6U/cm2, local application's amount of growth factor is 0.6 μ g/10cm2, the mass fraction of nano silver For 5ppm, usage amount 5g.
The Chinese medicine of Chinese medicine composition decoction liquor includes the component of following weight: radices trichosanthis 10g, sweet wormwood 12g, Radix Angelicae Sinensis 10g, peach Benevolence 15g, safflower 10g, dandelion 15g, olibanum 8g, myrrh 12g, calomel mercurous chloride 4g, litharge 10g and borneol 12g.
The decocting method of Chinese medicine composition decoction liquor comprises the following steps that
Step 1: the water that 944g is added decocts 30min, filters out medical fluid, obtains the first medical fluid；
Step 2: the addition of the first medical fluid being mixed after continuously adding the water decoction 20min of Chinese medicine composition weight 236g, continues to decoct 5min is boiled, medical fluid is filtered out, obtains Chinese medicine composition decoction liquor.
The application method of diabetic foot wound externally applied drug, includes the following steps,
S1: the cleaning surface of a wound, the surface of a wound are first cleaned with 0.9% sodium chloride injection, after the Iodophor cleaning surface of a wound with 1%, then with 0.9% sodium chloride injection is thorough；
S2: Chinese medicine composition decoction liquor, insulin, growth factor and Nano silver solution are imposed on by foot trauma therapeutic equipment Patient skin surface；
S3: seance is completed, continual cure 20min after conveying to vulneraia, and foot is taken out the treatment completion of chamber 117 and is controlled It treats.
Comparative example one
Comparative example one and the difference of embodiment one be, the diabetic foot wound externally applied drug prepared is adopted as by by wound Externally applied drug is poured on to be applied on clean gauze and use.
Comparative example two
Comparative example two and the difference of embodiment one are that the diabetes externally applied drug prepared does not contain growth factor.
Comparative example three
Comparative example three and the difference of embodiment one are that the diabetes externally applied drug prepared does not contain insulin.
Note: growth factor selection bFGF bovine basic fibroblast growth factor or recombined human table in embodiment and comparative example Skin growth factor.
It is continuous to treat and in medication to be administered once a day.
Clinical test
Criterion of therapeutical effect:
Clinical cure: local swelling disappears, and skin color is multiple normal, and ulcer surface heals completely.
Effective: local swelling and skin color are obviously improved, and ulcer surface reduces 70% or more.
Effective: local swelling and skin color are obviously improved, and ulcer surface reduces 30% or more.
It is invalid: effective standard is not achieved.
320 patients are selected, treatment group and embodiment group, every group of random 40 people are divided into.
Embodiment group: male 100, female 100, the age 32-79 years old, average age 63.5 years old, the course of disease 6 days to 20 months, It is 4 months average.
Comparative example group: male 60, the age 30-79 years old, average age 68.8 years old, the course of disease 6 days to 20 months, puts down by female 60 Equal 5 months.
Induced factor: scald 50, wound squeeze 50, and paronychia 50, electricity wound 20, tinea pedis 40, nothing obviously lures Because of 110.
Ulcer spot: toes 227, vola 52, heel 41.
Ulcer area is selected in 1.5-11cm2.
It is treated using the foot trauma externally applied drug of embodiment 1-5 and comparative example 1-3, therapeutic effect see the table below.
Patient numbers Healing/% Effective/% Effectively/% In vain/% Total effective rate/%
Embodiment 1 30 15(50) 12(40) 2(6.7) 1(3.3) 29(96.7)
Embodiment 2 30 16(53.3) 12(40) 2(6.7) 0(0) 30(100)
Embodiment 3 30 16(53.3) 12(40) 1(3.3) 1(3.3) 29(96.7)
Embodiment 4 30 14(46.7) 13(43.3) 3(10) 0(0) 30(100)
Embodiment 5 30 17(56.7) 11(36.7) 2(6.7) 0(0) 30(100)
Comparative example 1 30 13(43.3) 9(30) 5(16.7) 3(10) 27(90)
Comparative example 2 30 13(43.3) 8(26.7) 3(10) 6(20) 24(80)
Comparative example 3 30 11(36.7) 6(20) 7(23.3) 6(20) 24(80)
It can be derived that by the experimental data of embodiment 1-5, the use effect of the diabetes wound externally applied drug of present specification Fruit is excellent, and total effective rate almost reaches recovery from illness, then illustrates, cooperation Chinese medicine, growth factor, Nano silver solution and insulin are in sugar It urinates significant in efficacy in the treatment of foot disease.
Secondly the experimental data for comparing comparative example 1-3, can effectively obtain, the cooperation of the drug of the application is to treatment glycosuria Foot disease has significant effect.
And clinical effectiveness is shown, the time of the diabetes wound externally applied drug recovery from illness of present specification is to control within 15 days It is shorter to treat the time.

Claims (10)

1. a kind of diabetic foot wound externally applied drug, which is characterized in that including Chinese medicine composition decoction liquor, insulin, growth because Son and Nano silver solution.
2. a kind of diabetic foot wound externally applied drug according to claim 1, which is characterized in that
The Chinese medicine of the Chinese medicine composition decoction liquor includes the component of following parts by weight: 10-12 parts of radices trichosanthis, sweet wormwood 10-12 It is part, 8-10 parts of Radix Angelicae Sinensis, 10-15 parts of peach kernel, 10-12 parts of safflower, 10-15 parts of dandelion, 5-8 parts of olibanum, 10-12 parts of myrrh, light 3-5 parts of powder, 8-10 parts of litharge and 10-12 parts of borneol.
3. a kind of diabetic foot wound externally applied drug according to claim 2, which is characterized in that the Chinese medicine composition is decocted The Chinese medicine of boil liquid includes the component of following parts by weight: 10 parts of radices trichosanthis, 12 parts of sweet wormwood, 10 parts of Radix Angelicae Sinensis, 15 parts of peach kernel, safflower 10 Part, 15 parts of dandelion, 8 parts of olibanum, 12 parts of myrrh, 4 parts of calomel mercurous chloride, 10 parts of litharge and 12 parts of borneol.
4. a kind of diabetic foot wound externally applied drug according to claim 2 or 3, which is characterized in that the Chinese traditional medicine composition The decocting method of object decoction liquor comprises the following steps that
Step 1: the water that 5-8 times of Chinese medicine composition weight is added decocts 20-30min, filters out medical fluid liquid, obtains the first medical fluid；
Step 2: the addition of the first medical fluid is mixed after continuously adding the water decoction 15-20min of 2-3 times of Chinese medicine composition weight, after It is continuous to decoct 2-5min, medical fluid is filtered out, Chinese medicine composition decoction liquor is obtained.
5. a kind of diabetic foot wound externally applied drug according to claim 1, which is characterized in that the part of the insulin Effective quantity is 0.5-0.6U/cm2, the topically effective amount of the growth factor is 0.5-0.6 μ g/10cm2。
6. a kind of diabetic foot wound externally applied drug according to claim 1, which is characterized in that the quality of the nano silver Score is 5ppm.
7. a kind of application method of diabetic foot wound externally applied drug as claimed in any one of claims 1 to 6, feature exist In, include the following steps,
S1: the cleaning surface of a wound；
S2: Chinese medicine composition decoction liquor, insulin, growth factor and Nano silver solution are imposed on by foot trauma therapeutic equipment Patient skin surface；
S3: seance is completed.
8. a kind of application method of diabetic foot wound externally applied drug according to claim 7, it is characterised in that, it is described Foot trauma therapeutic equipment includes protection shell (1), and treatment case (11), the guarantor are fixedly connected on the protection shell (1) Oxygenerator (12) and ultrasonic atomizer (13) are provided in protective case body (1), be provided in treatment case (11) treat chamber (117) and For the sealing element of closed treating chamber (117), in being provided with sterile film (111), oxygenerator in the treatment chamber (117) (12) it is set in protection shell (1) and is connected to the sterile film (111) by oxygen cathete (121), ultrasonic atomizer (13) It is set in protection shell (1) and is connected to the sterile film (111) by grug transportation tube (131), opened on the treatment case (11) It equipped with taking mouth (112), is slidably connected on ultrasonic atomizer (13) kit (116), sliding kit (116), which is stretched out, takes object Mouth (112) is slidably connected shutter (113) on the taking mouth (112), is set on the sterile film (111) to add drug It is equipped with the first connector for oxygen cathete (121) connection and the second connector for grug transportation tube (131) connection, first connection The shaping ring (1112) for oxygen cathete (121) and grug transportation tube (131) installation is provided at mouth and the second connector.
9. a kind of application method of diabetic foot wound externally applied drug according to claim 8, it is characterised in that, it is described Sealing element includes the first sealing plate (114) being hinged on treatment case (11), is provided on first sealing plate (114) The first aperture (1141), be hinged on it is described treatment case (11) on the second sealing plate (115), be provided with second sealing plate (115) the second aperture (1151) on, first aperture (1141) and the second aperture (1151) split are formed for holding Receive the receiving hole of patient legs.
10. a kind of application method of diabetic foot wound externally applied drug according to claim 9, it is characterised in that, including Following steps,
S1: the cleaning surface of a wound；
S2: Chinese medicine composition decoction liquor, insulin, growth factor and Nano silver solution are put in kit, patient stretches foot Enter to the sterile film (111) in treatment chamber (117), oxygenerator (12) conveys oxygen to treating chamber (117), ultrasonic atomizatio Vulneraia atomization is delivered in treatment chamber (117) and contacts with the surface of a wound by device (13)；
S3: seance is completed, continual cure 15-20min after conveying to vulneraia, and foot is taken out treatment chamber (117) Complete treatment.
CN201910014889.1A 2019-01-05 2019-01-05 A kind of diabetic foot wound externally applied drug and its application method Pending CN109529022A (en)

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