CN103768290A - Traditional Chinese medicine composition for treating synovitis and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating synovitis and preparation method thereof Download PDF

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CN103768290A
CN103768290A CN201410062439.7A CN201410062439A CN103768290A CN 103768290 A CN103768290 A CN 103768290A CN 201410062439 A CN201410062439 A CN 201410062439A CN 103768290 A CN103768290 A CN 103768290A
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chinese medicine
synovitis
medicine composition
weight
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刘睿
刘朝晖
王俊卿
朱银星
周菲华
郭克锋
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刘睿
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Abstract

The invention discloses a traditional Chinese medicine composition for treating synovitis and a preparation method thereof. The traditional Chinese medicine composition is prepared from active components of the following crude drugs in parts by weight: 10-20 parts of apricot leaves, 10-20 parts of isatis root, 15-25 parts of tuckahoe, 15-25 parts of rhizoma alismatis, 10-20 parts of honeysuckle, 10-20 parts of safflower, 1-5 parts of as arum, 20-30 parts of rhizoma corydalis and 2-10 parts of liquorice. The formula is unique; through mutual synergistic effects of nine drugs, the traditional Chinese medicine composition disclosed by the invention has the effects of alleviating pain and diminishing inflammation as well as treating both syndromes and root causes of disease, and is suitable for syndromes such as osteoproliferation type synovitis, meniscus injury type synovitis, infantile synovitis and the like, wide in application range, free of any side effect, low in cost and simple to take.

Description

A kind of Chinese medicine composition for the treatment of synovitis and preparation method thereof
Technical field
The invention belongs to medical technical field, be specifically related to a kind of Chinese medicine composition for the treatment of synovitis and preparation method thereof.
Background technology
Synovitis is a kind of multiple diseases, and its cause of disease comprises wound, rheumatism, articular degeneration, tuberculosis infection etc.Site of pathological change is mainly in knee joint, knee joint is that human body synovial membrane is maximum, articular surface maximum and the most complicated joint of structure, because knee joint synovial membrane is extensive and be positioned at limbs table compared with superficial part position, therefore the chance of being damaged and infect is more, gonarthromeningitis is mainly because of sprain of knee joint and multiple intraarticular damage, and the one group of syndrome causing.Easily cause the temporary transient or long-term part disability of patient and reduce quality of life, to patient and all larger to social harm.
At present, the method for the treatment of clinically synovitis has tcm therapy class: oral medicinal herb, Chinese medicine external, massage, acupuncture, Chinese medicine lavation etc., western medicine therapy: Western medicine is for oral administration, Western medicine external, joint cavity injection medicine, ice treatment, ultrashort wave, infrared ray, ultrasound wave, magnetic therapy, intermediate frequency, TDP, operation etc.Chinese and western medicine system medication side effect is large, and medicine causes to a certain degree infringement to liver, and curative effect is undesirable, and the means such as acupuncture and tuina-massage are not strong to synovitis patient symptom specific aim, and hydrops absorbs slowly, and curative effect is not obvious.Sealing, lavation therapy causes infection risk, can not Reusability, easily cause synovial membrane, ligament and cartilaginous tissue degeneration.Local topical drug treatment, Western medicine cannot solve swelling hydrops problem, and local inflammation dissipation role is poor.Above-mentioned therapeutic modality is all longer the course for the treatment of, and therapeutic effect is not ideal enough; While adopting joint replacement surgery, because treatment cost and the going down of service life and function of joint of joint replacement surgery still can not be accepted for most of patient.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of synovitis, this Chinese medicine composition antiinflammatory, analgesic effect are good, and compliance is good, can reach treating both the principal and secondary aspects of a disease.
The technical solution adopted in the present invention is, a kind of Chinese medicine composition for the treatment of synovitis, raw material the effective elements of the medicine by following weight portion is made: Folium Pruni 10-20 part, Radix Isatidis 10-20 part, Poria 15-25 part, Rhizoma Alismatis 15-25 part, Flos Lonicerae 10-20 part, Flos Carthami 10-20 part, Herba Asari 1-5 part, Rhizoma Corydalis 20-30 part, Radix Glycyrrhizae 2-10 part.
Feature of the present invention is also,
Preferably made by the raw material the effective elements of the medicine of following weight portion: 15 parts of Folium Pruni, 15 parts of Radix Isatidis, 20 parts, Poria, 20 parts of Rhizoma Alismatis, 15 parts of Flos Loniceraes, 15 parts, Flos Carthami, 3 parts of Herba Asaris, 25 parts of Rhizoma Corydalis, 6 parts, Radix Glycyrrhizae.
Another kind of technical scheme of the present invention is, a kind of preparation method of Chinese medicine composition for the treatment of synovitis,
Step 1 is that following weight portion takes by crude drug by its effective ingredient: Folium Pruni 10-20 part, Radix Isatidis 10-20 part, Poria 15-25 part, Rhizoma Alismatis 15-25 part, Flos Lonicerae 10-20 part, Flos Carthami 10-20 part, Herba Asari 1-5 part, Rhizoma Corydalis 20-30 part, Radix Glycyrrhizae 2-10 part;
Step 2, mixes by all medicines that take in step 1 water that adds 6-12 times of weight, decocts and extracts three times, each 1-3 hour; Collecting decoction, is concentrated into relative density 2.1 ± 0.05, static 12-24 hour, and leaching supernatant, concentrates and obtains Chinese medicine composition of the present invention.
Be preferably that following weight portion takes by crude drug by its effective ingredient: 15 parts of Folium Pruni, 15 parts of Radix Isatidis, 20 parts, Poria, 20 parts of Rhizoma Alismatis, 15 parts of Flos Loniceraes, 15 parts, Flos Carthami, 3 parts of Herba Asaris, 25 parts of Rhizoma Corydalis, 6 parts, Radix Glycyrrhizae.
The invention has the beneficial effects as follows: the present invention's uniqueness of filling a prescription, by mutual synergism between nine herbal medicines, improve local blood circulation, accelerate metabolism, alleviate articular cavity inflammation, can drug effect impel hydrops backflow to absorb, place synovial membrane adhesion, improve articular cavity nutrition, prevent that cartilage is aging, have antalgic and inflammation relieving, the effect for the treatment of both the principal and secondary aspects of a disease, is applicable to the symptoms such as hyperosteogeny type synovitis, meniscus injury type synovitis, children's's synovitis, applied widely, without any side effects, with low cost, take simple.
The specific embodiment
Below in conjunction with embodiment, the present invention is described in detail.
The invention provides a kind of Chinese medicine composition for the treatment of synovitis, raw material the effective elements of the medicine by following weight portion is made: Folium Pruni 10-20 part, Radix Isatidis 10-20 part, Poria 15-25 part, Rhizoma Alismatis 15-25 part, Flos Lonicerae 10-20 part, Flos Carthami 10-20 part, Herba Asari 1-5 part, Rhizoma Corydalis 20-30 part, Radix Glycyrrhizae 2-10 part.
The present invention is preferably made up of the raw material the effective elements of the medicine of following weight portion: 15 parts of Folium Pruni, 15 parts of Radix Isatidis, 20 parts, Poria, 20 parts of Rhizoma Alismatis, 15 parts of Flos Loniceraes, 15 parts, Flos Carthami, 3 parts of Herba Asaris, 25 parts of Rhizoma Corydalis, 6 parts, Radix Glycyrrhizae.
One, function and the function of each raw material in this medicine cures mainly
Folium Pruni: return through liver; Spleen channel, expelling wind and removing dampness; Improving eyesight, main edema; Skin pruritus; The many tear of order disease; Carbuncle skin ulcer scrofula.
Radix Isatidis: taste is micro-sweet, a little less than feeble QI, has effect of heat-clearing and toxic substances removing, removing heat from blood detumescence.
Poria: sweet in the mouth, light, property are flat, has the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.
Rhizoma Alismatis: sweet in the mouth, light, cold in nature; Enter kidney, urinary bladder channel, promoting diuresis to eliminate damp pathogen; Expel the heat-evil treating stranguria; Main dysuria; The puckery pain of pyretic stranguria; Edema distension; Have loose bowels; Dizziness due to fluid-retention.
Flos Lonicerae: cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency and treats effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.
Flos Carthami: acrid in the mouth, warm in nature.GUIXIN, Liver Channel; There is effect of promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.Cure mainly the stagnant symptom such as swell and ache of abdominal pain due to blood stasis, traumatic injury, the stasis of blood.
Herba Asari: warm in nature, slightly poisonous; GUIXIN, lung, kidney channel; Dispel the wind, cold expelling, warming the lung, Hang Shui, the effect of having one's ideas straightened out.
Rhizoma Corydalis: warm in nature, acrid in the mouth hardship, enters the heart, spleen, liver, lung, is blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain.
Radix Glycyrrhizae: nature and flavor are sweet, flat; GUIXIN, lung, spleen, stomach warp; Effect: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The mutual synergism of said medicine, make this medical instrument have antiinflammatory, analgesic effect good, and compliance is good, can reach the effect for the treatment of both the principal and secondary aspects of a disease; Apply to the clinical slight illness that efficiently solves most of synovitis patient, curative effect is outstanding, economical cheap, and patient is easy to accept, and the characteristic of simultaneously having given prominence to Chinese medicine, has promoted the development of traditional Chinese medical science osteopathia.
Because synovitis is osteoarthrosis commonly encountered diseases, the course of disease is touching, outbreak repeatedly, inquire into and sum up by the clinical observations of nearly 10 years, etiology and pathogenesis, Chinese medicine composition of the present invention is applied to clinical, bring glad tidings to numerous Causes of Acute Traumatic synovitis and chronic synovitis patient, the economic benefit of also bringing to hospital and social benefit.
Two, preparation method and usage and dosage
The preparation method of a kind of Chinese medicine composition for the treatment of synovitis of the present invention, specifically implement according to following steps:
Step 1 is that following weight portion takes by crude drug by its effective ingredient: Folium Pruni 10-20 part, Radix Isatidis 10-20 part, Poria 15-25 part, Rhizoma Alismatis 15-25 part, Flos Lonicerae 10-20 part, Flos Carthami 10-20 part, Herba Asari 1-5 part, Rhizoma Corydalis 20-30 part, Radix Glycyrrhizae 2-10 part;
Step 2, mixes by all medicines that take in step 1 water that adds 6-12 times of weight, decocts and extracts three times, each 1-3 hour; Collecting decoction, is concentrated into relative density 2.1 ± 0.05, static 12-24 hour, and leaching supernatant, concentrates and obtains Chinese medicine composition of the present invention.
The Chinese medicine compound of above-mentioned a kind of Chinese medicine composition for the treatment of synovitis is combined the medicine of the various dosage forms that can be made into pharmaceutically acceptable carrier; described dosage form is oral liquid, tablet, capsule preparations or granule; the preparation method of various dosage forms technique routinely; decoction sterilizing is made to liquid preparation; or add the adjuvants such as dextrin; granule processed or make other solid preparation, as tablet, capsule or micropill.
Usage and the consumption of a kind of Chinese medicinal composition capsules preparation for the treatment of synovitis of the present invention:
Oral, a 2-3 grain, every containing crude drug 0.25g, 3 times on the one.
Embodiment 1
Be that following weight portion takes by crude drug by its effective ingredient: Folium Pruni 10g, Radix Isatidis 20g, Poria 15g, Rhizoma Alismatis 25g, Flos Lonicerae 10g, Flos Carthami 20g, Herba Asari 1g, Rhizoma Corydalis 30g, Radix Glycyrrhizae 2g; The all medicines that take are mixed to the water that adds 12 times of weight, decoct and extract three times, each 2 hours; Collecting decoction, is concentrated into relative density 2.1, and static 24 hours, leaching supernatant, concentrated and obtain Chinese medicine composition of the present invention, and this Chinese medicine composition is added to the adjuvants such as dextrin, makes capsule preparations.
Embodiment 2
Be that following weight portion takes by crude drug by its effective ingredient: Folium Pruni 20g, Radix Isatidis 10g, Poria 25g, Rhizoma Alismatis 15g, Flos Lonicerae 20g, Flos Carthami 10g, Herba Asari 5g, Rhizoma Corydalis 20g, Radix Glycyrrhizae 10g; The all medicines that take are mixed to the water that adds 6 times of weight, decoct and extract three times, each 1 hour; Collecting decoction, is concentrated into relative density 2.15, and static 13 hours, leaching supernatant, concentrated and obtain Chinese medicine composition of the present invention, and this Chinese medicine composition is added to the adjuvants such as dextrin, makes tablet.
Embodiment 3
Be that following weight portion takes by crude drug by its effective ingredient: Folium Pruni 15g, Radix Isatidis 15g, Poria 20g, Rhizoma Alismatis 20g, Flos Lonicerae 15g, Flos Carthami 15g, Herba Asari 3g, Rhizoma Corydalis 25g, Radix Glycyrrhizae 6g.The all medicines that take are mixed to the water that adds 9 times of weight, decoct and extract three times, each 3 hours; Collecting decoction, is concentrated into relative density 2.05, and static 12 hours, leaching supernatant, concentrated and obtain Chinese medicine composition of the present invention, and this Chinese medicine composition is added to the adjuvants such as dextrin, makes capsule preparations.
Three, Clinic Case
Case 1: Lin, man, duplex, two hip pain 2 months, the swelling of double knee joint moderate, result of laboratory test is rheumatoid factor (RF) feminine gender, and erythrocyte sedimentation rate (ESR) 115mm/h gives the capsule preparations of the oral embodiment of the present invention 1, and the Comprehensive Treatment 20 days of being admitted to hospital, arthralgia disappears, and double knee joint swelling disappears, without deadlock in morning, be rheumatoid factor (RF) feminine gender to hospital's review result, erythrocyte sedimentation rate (ESR) 15mm/h.
Case 2: in clinical, 15 typical synovitis patients take the tablet of the embodiment of the present invention 2, every day three times, each two, warm water delivery service after meal, taking the patient that reaching for 30 days swells and ache alleviates is 8 examples, the patient who takes 50 days pain reliefs is 5 examples, and the patient who takes 60 days pain reliefs is 2 examples, and after stopping using, no case was recurrence.
Case 3: the Qin, female, 45 years old, whole body arthralgia, more than 3 years, the multiple analgesic drug product of long-term taking, is also taking analgesic while not examining, looks into rheumatoid factor (+) through chemical examination, erythrocyte sedimentation rate speeds, anti-" 0 " is normal, and the stiff time is greater than 1 hour in morning in the morning, and clinical diagnosis is rheumatoid arthritis, take the capsule preparations that the present invention takes the embodiment of the present invention 3, after 28 days, effect is very remarkable, continues again for oral administration, external and combines, treat after 60 days, reexamine, rheumatoid factor and indices are all replied normally, follow up a case by regular visits to and within 3 years, have no recurrence.
Case 4: Lee, man, 33 years old, because occurring the right gonalgia after moving, swelling heating, companion's limitation of activity, right knee joint is without snap, and right knee joint patella grinds the style positive.Right knee joint patella upper limb tenderness, thirsty, sweating, yellow urine, large dry stool.Red tongue, yellowish fur.Looking into MRI shows: right Articular effusion in knee joint, be diagnosed as right gonarthromeningitis, take the capsule preparations of the embodiment of the present invention 3, one time 3, one day 3 times, warm water delivery service, after 30 days, pain relief, swelling dies down, continue to take after 30 days, symptom disappears completely, and tcm symptom sign is obviously improved.

Claims (4)

1. treat the Chinese medicine composition of synovitis for one kind, it is characterized in that, raw material the effective elements of the medicine by following weight portion is made: Folium Pruni 10-20 part, Radix Isatidis 10-20 part, Poria 15-25 part, Rhizoma Alismatis 15-25 part, Flos Lonicerae 10-20 part, Flos Carthami 10-20 part, Herba Asari 1-5 part, Rhizoma Corydalis 20-30 part, Radix Glycyrrhizae 2-10 part.
2. a kind of Chinese medicine composition for the treatment of synovitis as claimed in claim 1, is characterized in that, is made up of the raw material the effective elements of the medicine of following weight portion: 15 parts of Folium Pruni, 15 parts of Radix Isatidis, 20 parts, Poria, 20 parts of Rhizoma Alismatis, 15 parts of Flos Loniceraes, 15 parts, Flos Carthami, 3 parts of Herba Asaris, 25 parts of Rhizoma Corydalis, 6 parts, Radix Glycyrrhizae.
3. the preparation method of a kind of Chinese medicine composition for the treatment of synovitis as claimed in claim 1, it is characterized in that step 1 is that following weight portion takes by crude drug by its effective ingredient: Folium Pruni 10-20 part, Radix Isatidis 10-20 part, Poria 15-25 part, Rhizoma Alismatis 15-25 part, Flos Lonicerae 10-20 part, Flos Carthami 10-20 part, Herba Asari 1-5 part, Rhizoma Corydalis 20-30 part, Radix Glycyrrhizae 2-10 part;
Step 2, mixes by all medicines that take in step 1 water that adds 6-12 times of weight, decocts and extracts three times, each 1-3 hour; Collecting decoction, is concentrated into relative density 2.1 ± 0.05, static 12-24 hour, and leaching supernatant, concentrates and obtains Chinese medicine composition of the present invention.
4. the preparation method of a kind of Chinese medicine composition for the treatment of synovitis as claimed in claim 3, it is characterized in that, be that following weight portion takes by crude drug by its effective ingredient: 15 parts of Folium Pruni, 15 parts of Radix Isatidis, 20 parts, Poria, 20 parts of Rhizoma Alismatis, 15 parts of Flos Loniceraes, 15 parts, Flos Carthami, 3 parts of Herba Asaris, 25 parts of Rhizoma Corydalis, 6 parts, Radix Glycyrrhizae.
CN201410062439.7A 2014-02-25 2014-02-25 Traditional Chinese medicine composition for treating synovitis and preparation method thereof Pending CN103768290A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105106490A (en) * 2015-09-02 2015-12-02 济南舜昊生物科技有限公司 Medicine for treating hip joint effusion of children and preparation method of medicine
CN107224528A (en) * 2017-05-28 2017-10-03 成都风靡生物科技有限公司 It is a kind of to be used to treat pill medicine of synovitis and preparation method thereof

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CN103316140A (en) * 2013-06-24 2013-09-25 周博 Drug for treating arthrophlogosis

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105106490A (en) * 2015-09-02 2015-12-02 济南舜昊生物科技有限公司 Medicine for treating hip joint effusion of children and preparation method of medicine
CN107224528A (en) * 2017-05-28 2017-10-03 成都风靡生物科技有限公司 It is a kind of to be used to treat pill medicine of synovitis and preparation method thereof

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