CN104043089A - Medical biological dressing suppository for treating hemorrhoid - Google Patents

Medical biological dressing suppository for treating hemorrhoid Download PDF

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Publication number
CN104043089A
CN104043089A CN201410299716.6A CN201410299716A CN104043089A CN 104043089 A CN104043089 A CN 104043089A CN 201410299716 A CN201410299716 A CN 201410299716A CN 104043089 A CN104043089 A CN 104043089A
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China
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parts
suppository
hemorrhoid
rhizoma
mixed
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CN201410299716.6A
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Chinese (zh)
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李嘉
李整风
李标
常立新
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Bozhou Zheng Feng Pharmacy Co Ltd
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Bozhou Zheng Feng Pharmacy Co Ltd
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Priority to CN201410299716.6A priority Critical patent/CN104043089A/en
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Abstract

The invention discloses a medical biological dressing suppository for treating hemorrhoid. The medical biological dressing suppository is prepared from a medicinal component and a suppository matrix, wherein the medicinal component is prepared from the following components in parts by weight: 18-20 parts of golden cypress, 12-15 parts of radix sophorae flavescentis, 12-15 parts of purslane, 5-8 parts of gleditsia sinensis, 6-8 parts of dried ginger, 8-12 parts of rheum officinale, 5-8 parts of verdigris, 8-10 parts of borneol, 3-6 parts of realgar, 15-18 parts of bidens pilosa L, 12-15 parts of rhizoma smilacis glabrae, 8-10 parts of common cnidium fruits, 5-8 parts of cortex dictamni, 5-8 parts of curcuma zedoary, 8-10 parts of folium artemisiae argyi, 6-8 parts of dried alum, 12-15 parts of blue salt and 6-8 parts of Sichuan pepper; the suppository matrix is prepared from the following components in percentage by weight: 22% of chitosan, 8% of carbopol and 70% of polyethylene glycol. The medical biological dressing suppository is prepared according to a traditional Chinese medicine formula so as to be free of toxic or side effect and capable of ensuring that hemorrhoid is not easy to recur; the suppository is used as the dosage form so as to have the advantages of high disintegration speed, absorption completeness, no injury to mucous membranes and cleanness, and effects are rapid to take; in addition, the medical biological dressing suppository is good in curative effect, long in acting time and favorable in curative effect for hemorrhage, swell, pain, astriction and the like caused by internal hemorrhoid, external hemorrhoid and mixed hemorrhoid.

Description

A kind of medical bio bressing bolt for the treatment of hemorrhoid
Technical field
The present invention relates to medical technical field, relate in particular to a kind of medical bio bressing bolt for the treatment of hemorrhoid.
Background technology
In recent years, due to the change of dietary structure and dietary habit, the diet taste that height is warm, pungent, heavy wool becomes many people, add because the caused abdominal pressure of obesity increases, make the sickness rate of hemorrhoid obviously increase, in whole anorectal disease, the sickness rate of hemorrhoid accounts for 87.3%.Hemorrhoid are soft vein groups by under human body rectum end mucosa and under anal canal skin, venous plexus flexing expansion forms.Hemorrhage, scratch where it itches, pain and to deviate from be four kinds of common clinical manifestations of hemorrhoid, hemorrhoid are also easy to cause anal and intestinal disease, anemia, gynecological inflammation, anal eczema, vegetative nerve wadding other systemic disease such as disorderly simultaneously.Therefore hemorrhoid are treated timely, extremely important.
At present the Therapeutic Method of hemorrhoid is had to operative therapy, medicine therapy for oral administration and medicine Topical therapy, operative therapy brings larger misery to patient, after being ill, easily produce complication, medicine therapy curative effect for oral administration is slow, and the dosage form that medicine Topical therapy is used mostly is lotion, the time of washing is conventionally comparatively of short duration, the time that medicament contacts with mucosa, seldom medicine can not retain simultaneously, and medicine can not be played a role fully, and curative effect is very micro-, zest is larger.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of medical bio bressing bolt for the treatment of hemorrhoid is provided, adopt Chinese medicine formula, zest is little, is difficult for recurrence, adopts suppository formulation, good effect, can give full play to drug action, rapid-action, acting duration is long, hemorrhage, the swelling that internal hemorrhoid, external hemorrhoid, mixed hemorrhoid are caused, pain, constipation etc. all have good curative effect.
The present invention adopts following technical scheme to achieve these goals:
A kind of medical bio bressing bolt for the treatment of hemorrhoid, by drug component and suppository base, made, described drug component is made by the component of following weight portion: Cortex Phellodendri 18-20 part, Radix Sophorae Flavescentis 12-15 part, Herba Portulacae 12-15 part, Fructus Gleditsia 5-8 part, Rhizoma Zingiberis 6-8 part, Radix Et Rhizoma Rhei 8-12 part, Aerugo 5-8 part, Borneolum Syntheticum 8-10 part, Realgar 3-6 part, bidens pilosa 15-18 part, Rhizoma Smilacis Glabrae 12-15 part, Fructus Cnidii 8-10 part, Cortex Dictamni 5-8 part, Rhizoma Curcumae 5-8 part, Folium Artemisiae Argyi 8-10 part, dried Alumen 6-8 part, the eleventh of the twelve Earthly Branches salt 12-15 part, another name for Sichuan Province green pepper 6-8 part;
Described suppository base is that 22% chitosan, 8% carbomer, 70% Polyethylene Glycol form by percentage by weight.
The preparation method of the medical bio bressing bolt of described treatment hemorrhoid, comprises following preparation process:
(1) according to the above ratio Cortex Phellodendri, Radix Sophorae Flavescentis, Herba Portulacae, Fructus Gleditsia, Rhizoma Zingiberis, Radix Et Rhizoma Rhei, bidens pilosa, Rhizoma Smilacis Glabrae, Fructus Cnidii, Cortex Dictamni, Rhizoma Curcumae, Folium Artemisiae Argyi are mixed, pulverize, decoct with water 2 times, each 2-3 hour, merge decocting liquid twice, filter, filtrate has concentrated, vacuum drying, be crushed to 200 orders, obtains medicated powder;
(2) according to the above ratio Aerugo, Borneolum Syntheticum, Realgar, dried Alumen, the eleventh of the twelve Earthly Branches salt, another name for Sichuan Province green pepper are mixed again, pulverize porphyrize to 200 order and obtain mixed powder;
(3) medicated powder of being prepared by step (1) mixes with mixed powder prepared by step (2), obtains mixed powder;
(4) according to the above ratio by chitosan, carbomer, Polyethylene Glycol heating and melting, be mixed to get suppository base;
(5) treat that suppository base is cooled to 50 ℃, add mixed powder, injection molding after mixing, cooling, pack, sealing sterilizing, the weight ratio of described mixed powder and suppository base is 4:6.
Using method: suppository of the present invention is filled in anus, one day twice, each one; During medication, avoid greasy, maror.
Chinese medicine thinks that hemorrhoid have inside and outside minute, and internal hemorrhoid is many because food delicious food is pungent, or be addicted to drink excessively, standing for a long time sitting, with the passing of time, the reasons such as pregnancy and delivery, cause the damp and hot interior life of wind-dryness to dysentery, qi and blood disorder, blockage of the vessel, the blood stasis foul smell anus of making a bet forms; External hemorrhoid many by evil poison invade outward, fissure in ano, the factors such as damp invasion of lower energizer cause blood fortune not smooth, vein the moon is stagnant, or dry because of interior warm blood, the nearly stasis of pyrogenicity forms.
In Chinese medicine formula of the present invention, Cortex Phellodendri has heat clearing and damp drying, pathogenic fire purging except steaming, the effect of detoxification sore treatment; Radix Sophorae Flavescentis has heat clearing and damp drying, dispels the wind, the effect of killing parasites for relieving itching, with Herba Portulacae compatibility, and the kind disease of controlling damp and hot sore or damp invasion of lower energizer; That Fructus Gleditsia has is antibacterial, the effect of detumescence sterilization; Rhizoma Zingiberis is the rhizome of zingiber, has warming spleen and stomach for dispelling cold effect; Radix Et Rhizoma Rhei has the effect of purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation; Aerugo is the green mandarin coat that bronze, brass or copper ware surface generates after carbon dioxide or acetic acid effect, the effect of have removing the necrotic tissue, sore, parasite killing, telling wind-phlegm; Borneolum Syntheticum has clearing away heat to alleviate pain, anti-inflammatory anti-itch, anticorrosion detumescence effect; Realgar has removing toxic substances parasite killing, removing dampness and eliminating phlegm effect; Bidens pilosa has heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling effect; Rhizoma Smilacis Glabrae has blood-cleaning detoxifying, the dampness removing hot merit effect of dispelling, and has the effect of Synergistic with bidens pilosa compatibility; Fructus Cnidii has dampness, parasite killing, dispelling wind for relieving itching effect; Cortex Dictamni, bitter cold, energy heat clearing and damp drying dispelling wind for relieving itching, is apt to control damp and hot sore skin pruritus; Rhizoma Curcumae has the effect of blood circulation promoting and blood stasis dispelling, the pain relieving of heat clearing away removing food stagnancy, removing the necrotic tissue and promoting granulation; Folium Artemisiae Argyi has removing dampness to relieve itching effect; Dried Alumen has convergence vagina, dampness removing and diarrhea-relieving, removing toxic substances disinsection efficiency; The eleventh of the twelve Earthly Branches salt has priming gas and enters this dirty effect; Another name for Sichuan Province green pepper has the effect of warming middle-JIAO to relieve pain, killing parasites for relieving itching;
Compared with the prior art, beneficial effect of the present invention is as follows:
The medical bio bressing bolt for the treatment of hemorrhoid of the present invention, adopts Chinese medicine formula, and zest is little, have no side effect, be difficult for recurrence, adopt suppository formulation, have disintegration rate fast, rapid-action, absorb completely, do not hinder mucosa, the advantage of clean hygiene, good effect, can give full play to drug action, acting duration is long, and hemorrhage, the swelling that internal hemorrhoid, external hemorrhoid, mixed hemorrhoid are caused, pain, constipation etc. all have good curative effect.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1:
A kind of medical bio bressing bolt for the treatment of hemorrhoid, by drug component and suppository base, made, described drug component is made by the component of following weight portion: 18 parts of Cortex Phellodendris, 15 parts of Radix Sophorae Flavescentiss, 12 parts of Herba Portulacaes, 5 parts, Fructus Gleditsia, 6 parts of Rhizoma Zingiberiss, 8 parts of Radix Et Rhizoma Rhei, 5 parts of Aerugo, 8 parts of Borneolum Syntheticums, 3 parts of Realgars, 15 parts of bidens pilosas, 12 parts of Rhizoma Smilacis Glabraes, 8 parts of Fructus Cnidiis, 5 parts of Cortex Dictamni, 5 parts of Rhizoma Curcumae, 8 parts of Folium Artemisiae Argyis, 6 parts of dried Alumens, 13 parts of the eleventh of the twelve Earthly Branches salt, 6 parts of another name for Sichuan Province greens pepper;
Described suppository base is that 22% chitosan, 8% carbomer, 70% Polyethylene Glycol form by percentage by weight.
Preparation method:
(1) according to the above ratio Cortex Phellodendri, Radix Sophorae Flavescentis, Herba Portulacae, Fructus Gleditsia, Rhizoma Zingiberis, Radix Et Rhizoma Rhei, bidens pilosa, Rhizoma Smilacis Glabrae, Fructus Cnidii, Cortex Dictamni, Rhizoma Curcumae, Folium Artemisiae Argyi are mixed, pulverize, decoct with water 2 times, each 2 hours, merge decocting liquid twice, filter, filtrate has concentrated, vacuum drying, be crushed to 200 orders, obtains medicated powder;
(2) according to the above ratio Aerugo, Borneolum Syntheticum, Realgar, dried Alumen, the eleventh of the twelve Earthly Branches salt, another name for Sichuan Province green pepper are mixed again, pulverize porphyrize to 200 order and obtain mixed powder;
(3) medicated powder of being prepared by step (1) mixes with mixed powder prepared by step (2), obtains mixed powder;
(4) according to the above ratio by chitosan, carbomer, Polyethylene Glycol heating and melting, be mixed to get suppository base;
(5) treat that suppository base is cooled to 50 ℃, add mixed powder, injection molding after mixing, cooling, pack, sealing sterilizing, the weight ratio of described mixed powder and suppository base is 4:6.
Embodiment 2:
A kind of medical bio bressing bolt for the treatment of hemorrhoid, by drug component and suppository base, made, described drug component is made by the component of following weight portion: 20 parts of Cortex Phellodendris, 13 parts of Radix Sophorae Flavescentiss, 13 parts of Herba Portulacaes, 6 parts, Fructus Gleditsia, 7 parts of Rhizoma Zingiberiss, 10 parts of Radix Et Rhizoma Rhei, 6 parts of Aerugo, 9 parts of Borneolum Syntheticums, 5 parts of Realgars, 16 parts of bidens pilosas, 13 parts of Rhizoma Smilacis Glabraes, 9 parts of Fructus Cnidiis, 6 parts of Cortex Dictamni, 6 parts of Rhizoma Curcumae, 9 parts of Folium Artemisiae Argyis, 7 parts of dried Alumens, 13 parts of the eleventh of the twelve Earthly Branches salt, 7 parts of another name for Sichuan Province greens pepper;
Described suppository base is that 22% chitosan, 8% carbomer, 70% Polyethylene Glycol form by percentage by weight.
Preparation method:
(1) according to the above ratio Cortex Phellodendri, Radix Sophorae Flavescentis, Herba Portulacae, Fructus Gleditsia, Rhizoma Zingiberis, Radix Et Rhizoma Rhei, bidens pilosa, Rhizoma Smilacis Glabrae, Fructus Cnidii, Cortex Dictamni, Rhizoma Curcumae, Folium Artemisiae Argyi are mixed, pulverize, decoct with water 2 times, each 3 hours, merge decocting liquid twice, filter, filtrate has concentrated, vacuum drying, be crushed to 200 orders, obtains medicated powder;
(2) according to the above ratio Aerugo, Borneolum Syntheticum, Realgar, dried Alumen, the eleventh of the twelve Earthly Branches salt, another name for Sichuan Province green pepper are mixed again, pulverize porphyrize to 200 order and obtain mixed powder;
(3) medicated powder of being prepared by step (1) mixes with mixed powder prepared by step (2), obtains mixed powder;
(4) according to the above ratio by chitosan, carbomer, Polyethylene Glycol heating and melting, be mixed to get suppository base;
(5) treat that suppository base is cooled to 50 ℃, add mixed powder, injection molding after mixing, cooling, pack, sealing sterilizing, the weight ratio of described mixed powder and suppository base is 4:6.
Embodiment 3:
A kind of medical bio bressing bolt for the treatment of hemorrhoid, by drug component and suppository base, made, described drug component is made by the component of following weight portion: 20 parts of Cortex Phellodendris, 15 parts of Radix Sophorae Flavescentiss, 15 parts of Herba Portulacaes, 8 parts, Fructus Gleditsia, 8 parts of Rhizoma Zingiberiss, 12 parts of Radix Et Rhizoma Rhei, 8 parts of Aerugo, 10 parts of Borneolum Syntheticums, 6 parts of Realgars, 18 parts of bidens pilosas, 15 parts of Rhizoma Smilacis Glabraes, 10 parts of Fructus Cnidiis, 8 parts of Cortex Dictamni, 8 parts of Rhizoma Curcumae, 10 parts of Folium Artemisiae Argyis, 8 parts of dried Alumens, 15 parts of the eleventh of the twelve Earthly Branches salt, 8 parts of another name for Sichuan Province greens pepper;
Described suppository base is that 22% chitosan, 8% carbomer, 70% Polyethylene Glycol form by percentage by weight.
Preparation method:
(1) according to the above ratio Cortex Phellodendri, Radix Sophorae Flavescentis, Herba Portulacae, Fructus Gleditsia, Rhizoma Zingiberis, Radix Et Rhizoma Rhei, bidens pilosa, Rhizoma Smilacis Glabrae, Fructus Cnidii, Cortex Dictamni, Rhizoma Curcumae, Folium Artemisiae Argyi are mixed, pulverize, decoct with water 2 times, each 3 hours, merge decocting liquid twice, filter, filtrate has concentrated, vacuum drying, be crushed to 200 orders, obtains medicated powder;
(2) according to the above ratio Aerugo, Borneolum Syntheticum, Realgar, dried Alumen, the eleventh of the twelve Earthly Branches salt, another name for Sichuan Province green pepper are mixed again, pulverize porphyrize to 200 order and obtain mixed powder;
(3) medicated powder of being prepared by step (1) mixes with mixed powder prepared by step (2), obtains mixed powder;
(4) according to the above ratio by chitosan, carbomer, Polyethylene Glycol heating and melting, be mixed to get suppository base;
(5) treat that suppository base is cooled to 50 ℃, add mixed powder, injection molding after mixing, cooling, pack, sealing sterilizing, the weight ratio of described mixed powder and suppository base is 4:6.
Test example: case load 200 examples, the age, the mean age was at 41.5 years old between 20-60.After adopting medicine of the present invention to treat, medication second day, 182 routine patients, proctalgia obviously alleviates; Continue on for after 3 days, hemorrhoid body or the obvious atrophy of skin ulcer face, and without pain, without having blood in stool phenomenon; For after 10 days, 192 routine patients, hemorrhoid body disappears completely, and without pain, patient returns to one's perfect health; Follow up a case by regular visits in 6 months, there is no recurrence.
Model case:
Case 1: Lee, man, 39 years old, programmer, proctalgia, walking, sitting and lying difficulty, and with having blood in stool, on inspection, for internal hemorrhoid, adopt Drug therapy of the present invention to treat, suppository is sent into anus, sooner or later respectively once, medication second day, pain relief, medication is after 5 days, and pain disappears, without having blood in stool, the obvious atrophy of hemorrhoid body, medication is after 10 days, hemorrhoid body disappears completely, and patient returns to one's perfect health, so far not recurrence.
Case 2: desolate certain, female, 40 years old, workers in enterprise, proctalgia, pruritus, has blood in stool, and through inspection, checks, for external hemorrhoid, adopt medicine of the present invention to treat, medicine is sent into anal, sooner or later respectively once, after medication 1 day, pain relief, after 3 days, the atrophy of hemorrhoid body, the disappearance of having blood in stool, pruritus no longer, medication is after 8 days, hemorrhoid body disappears completely, state of an illness recovery from illness, so far not recurrence.

Claims (2)

1. a medical bio bressing bolt for the treatment of hemorrhoid, it is characterized in that: by drug component and suppository base, made, described drug component is made by the component of following weight portion: Cortex Phellodendri 18-20 part, Radix Sophorae Flavescentis 12-15 part, Herba Portulacae 12-15 part, Fructus Gleditsia 5-8 part, Rhizoma Zingiberis 6-8 part, Radix Et Rhizoma Rhei 8-12 part, Aerugo 5-8 part, Borneolum Syntheticum 8-10 part, Realgar 3-6 part, bidens pilosa 15-18 part, Rhizoma Smilacis Glabrae 12-15 part, Fructus Cnidii 8-10 part, Cortex Dictamni 5-8 part, Rhizoma Curcumae 5-8 part, Folium Artemisiae Argyi 8-10 part, dried Alumen 6-8 part, the eleventh of the twelve Earthly Branches salt 12-15 part, another name for Sichuan Province green pepper 6-8 part;
Described suppository base is that 22% chitosan, 8% carbomer, 70% Polyethylene Glycol form by percentage by weight.
2. the preparation method of the medical bio bressing bolt for the treatment of hemorrhoid according to claim 1, is characterized in that: comprise following preparation process:
(1) according to the above ratio Cortex Phellodendri, Radix Sophorae Flavescentis, Herba Portulacae, Fructus Gleditsia, Rhizoma Zingiberis, Radix Et Rhizoma Rhei, bidens pilosa, Rhizoma Smilacis Glabrae, Fructus Cnidii, Cortex Dictamni, Rhizoma Curcumae, Folium Artemisiae Argyi are mixed, pulverize, decoct with water 2 times, each 2-3 hour, merge decocting liquid twice, filter, filtrate has concentrated, vacuum drying, be crushed to 200 orders, obtains medicated powder;
(2) according to the above ratio Aerugo, Borneolum Syntheticum, Realgar, dried Alumen, the eleventh of the twelve Earthly Branches salt, another name for Sichuan Province green pepper are mixed again, pulverize porphyrize to 200 order and obtain mixed powder;
(3) medicated powder of being prepared by step (1) mixes with mixed powder prepared by step (2), obtains mixed powder;
(4) according to the above ratio by chitosan, carbomer, Polyethylene Glycol heating and melting, be mixed to get suppository base;
(5) treat that suppository base is cooled to 50 ℃, add mixed powder, injection molding after mixing, cooling, pack, sealing sterilizing, the weight ratio of described mixed powder and suppository base is 4:6.
CN201410299716.6A 2014-06-27 2014-06-27 Medical biological dressing suppository for treating hemorrhoid Pending CN104043089A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105497709A (en) * 2014-10-14 2016-04-20 黄名玉 External decoction for treating hemorrhoids
CN108853167A (en) * 2018-09-13 2018-11-23 广州润虹医药科技股份有限公司 A kind of hemorrhoid composition containing chitosan, preparation method and applications

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105497709A (en) * 2014-10-14 2016-04-20 黄名玉 External decoction for treating hemorrhoids
CN108853167A (en) * 2018-09-13 2018-11-23 广州润虹医药科技股份有限公司 A kind of hemorrhoid composition containing chitosan, preparation method and applications

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