CN109432245A - It is a kind of to have effects that the Chinese medicine composition of putrefaction-removing granulation-promoting, preparation and application - Google Patents
It is a kind of to have effects that the Chinese medicine composition of putrefaction-removing granulation-promoting, preparation and application Download PDFInfo
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Abstract
The present invention relates to the field of Chinese medicines, specifically, are related to a kind of having effects that the Chinese medicine composition of putrefaction-removing granulation-promoting, preparation and application.Contain 50~100 parts by weight of rheum officinale, 30~60 parts by weight of radix ampelopsis, 30~60 parts by weight of the root of Dahurain angelica, 5~20 parts by weight of cape jasmine, 10~40 parts by weight of catechu, 10~30 parts by weight of calamine in Chinese medicine composition of the invention.The present invention festers to diabetic foot ulcer, vasculitis, bedsore, burn and scald and various skin injury ulcer, festering etc. has extraordinary curative effect, and treatment cycle is short, significantly reduces the pain and financial burden of patient.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically, are related to a kind of having effects that the Chinese medicine composition of putrefaction-removing granulation-promoting, preparation
And application.
Background technique
Chronic ulcer of skin refers to that for the tissue repair under normal physiological condition, the healing time of the surface of a wound is more than
4 weeks, and the disrupted tissue without obvious healing tendency, therefore also known as intractable ulcer, generally have the cause of disease is complicated, the course of disease is long,
Recurrent exerbation, rear easily recurrence, minority still have the features such as canceration is possible again.Classify from the cause of disease, intractable ulcer generally wraps
Diabetic foot ulcer, venous ulcer, denervation ulcer, pressure ulcer, extensive deep burn ulcer, electric injury is included to burst
The wound and wound surface etc. occurred in ulcer, large dosage of environment such as radiation injury ulcer and plateau, sea area.At present for chronic ulcer of skin
Treatment, there is no unified specific practice guidelines, previously usually give that surface of a wound debridement, common dressing for a long time is even made skin graft or skin
The processing such as valve reparation, but curative effect is not good enough, therefore becomes in clinical position and cannot be neglected a great problem.
Especially diabetic foot ulcer, later period deteriorate very fast, it is likely that amputation is faced in one week, it is dead in 30 days after amputation
Die rate 10%.But the drug still without the treatment diabetes of curative effect certainly domestic and international at present.
If burnt degree is handled not in time or dealt with improperly, it can lead to trauma surface infestation, delay wound healing, or even jeopardize patient
Life.Traditional Chinese medicine has unique advantage with the principle of dialectical treatmert in terms for the treatment of burn.It is applied to burn, curative effect at present
Preferable Chinese materia medica preparation is Runshi burns paste, it realizes the in-situ regeneration of skin, is the field technology in modern burn field
Property revolution, but moist exposed burn cream exist treatment the depth of burn surface of a wound time it is longer, the slow problem of curative effect.
Patent " diabetic foot ointment " (application No. is 201310459029.1) disclose it is a kind of by Radix Notoginseng, the coptis, Paris polyphylla,
Traditional Chinese herb medicine made of 39 kinds of Chinese medicine materials such as bletilla, the ointment can be relieved and prevent the pain of patient with diabetic feet, can press down
Bacterial growth processed is allowed to nature extinction, the surface of a wound can be made to form moist environment, be conducive to the reparation of wound tissue, avoid operation
It cuts scab and cuts scab, amputation, the pain for cutting toe and bring and seriously damage, epithelial tissue, granulation tissue, surface of a wound capilary can be promoted
Growth.But raw material contained by said preparation is numerous, causes complex process, and the treatment phase for being applied to diabetic foot ulcer is up to 1~2
Year, treatment time is long, and curative effect is slow.
Patent application " a kind of putrefaction-removing granulation-promoting paste and preparation method thereof " (application No. is 201711186967.3) discloses one
Kind by the Chinese medicinal compositions such as Radix Angelicae Sinensis, Asian puccoon, Radix Glycyrrhizae, olibanum ointment, have effects that removing toxic substances relieve the pain, invigorate blood circulation, dispel corruption, myogenic, energy
Enough treat various sore swollen toxins.Can be used for treating bedsore, burn and scald, hemorrhoid, shingles zoster and worm bee sting wise wound, for the edge of a knife or
The long-term disunion of the open sore part has a better effect.But the patent need to prepare No. 1 cream and No. 2 cream respectively, and two kinds of ointment need to be used cooperatively,
It makes troubles to preparation and patient's use.
In consideration of it, the present invention is specifically proposed.
Summary of the invention
Primary goal of the invention of the invention is to propose a kind of have effects that the Chinese medicine composition of putrefaction-removing granulation-promoting.
Second goal of the invention of the invention is to propose the preparation of the Chinese medicine composition.
Third goal of the invention of the invention is to propose the application of the Chinese medicine composition and preparation.
In order to complete the purpose of the present invention, the technical solution of use are as follows:
The present invention propose it is a kind of have effects that the Chinese medicine composition of putrefaction-removing granulation-promoting, containing with the following group in the Chinese medicine composition
Point:
50~100 parts by weight of rheum officinale, 30~60 parts by weight of radix ampelopsis, 30~60 parts by weight of the root of Dahurain angelica, 5~20 parts by weight of cape jasmine,
10~40 parts by weight of catechu, 10~30 parts by weight of calamine.
Optionally, borneol, olibanum and myrrh are also contained in the Chinese medicine composition:
Preferably, 15~50 parts by weight of borneol, 20~40 parts by weight of olibanum, myrrh 5 are also contained in the Chinese medicine composition
~20 parts by weight；
It is furthermore preferred that containing 40~80 parts by weight of rheum officinale, 30~40 parts by weight of radix ampelopsis, the root of Dahurain angelica 30 in the Chinese medicine composition
~45 parts by weight, 10~20 parts by weight of cape jasmine, 20~30 parts by weight of catechu, 15~20 parts by weight of calamine, 30~45 weight of borneol
Measure part, 5~15 parts by weight of 30~40 parts by weight of olibanum and myrrh.
Optionally, in the Chinese medicine composition also contain other compositions I, the other compositions I be selected from Radix Notoginseng, pearl powder,
At least one of great burdock achene, lobelia chinensis and polygonum cuspidate；
Preferably, 10~20 parts by weight of Radix Notoginseng, 10~20 parts by weight of pearl powder, fructus arctii are also contained in the Chinese medicine composition
Sub 10~20 parts by weight, 10~20 parts by weight of lobelia chinensis, 10~20 parts by weight of polygonum cuspidate；
It is furthermore preferred that also containing 10 parts by weight of Radix Notoginseng, 15 parts by weight of pearl powder, 15 weight of great burdock achene in the Chinese medicine composition
Measure part, 20 parts by weight of lobelia chinensis, 10 parts by weight of polygonum cuspidate.
Optionally, in the Chinese medicine composition also contain other compositions II, the other compositions II be selected from Radix Angelicae Sinensis, radix scrophulariae,
At least one of asarum, polygonum cuspidate, safflower, dragon's blood and calcined gypsum；
Preferably, 10~20 parts by weight of Radix Angelicae Sinensis, 10~20 parts by weight of asarum, polygonum cuspidate 10 are also contained in the Chinese medicine composition
~20 parts by weight, 10~20 parts by weight of dragon's blood, 10~20 parts by weight of calcined gypsum；It is furthermore preferred that also containing in the Chinese medicine composition
There are 10 parts by weight of Radix Angelicae Sinensis, 15 parts by weight of asarum, 20 parts by weight of polygonum cuspidate, 10 parts by weight of dragon's blood, 10 parts by weight of calcined gypsum；
Preferably, 10~20 parts by weight of Radix Angelicae Sinensis, 10~20 parts by weight of radix scrophulariae, safflower 10 are also contained in the Chinese medicine composition
~20 parts by weight, 10~20 parts by weight of calcined gypsum；It is furthermore preferred that also containing 20 parts by weight of Radix Angelicae Sinensis, profound in the Chinese medicine composition
Join 10 parts by weight, 15 parts by weight of safflower, 10 parts by weight of calcined gypsum.
Optionally, the dosage form of the preparation is ointment, paste, finish, paint, patch, emplastrum or film.
Optionally, auxiliary material is also contained in the preparation, it is auxiliary that the auxiliary material is selected from solvent, ointment bases, filmogen, cream processed
At least one of material；
The solvent is selected from least one of peanut oil, soybean oil, sesame oil；The ointment bases is selected from lanolin, all
At least one of intellectual circle, beeswax, paraffin, Chinese wax；The filmogen is selected from polyvinyl alcohol, acrylic resin, cellulose
At least one of class high molecular material；The cream auxiliary material processed is selected from least one of red lead, lead powder.
Optionally, the preparation is prepared using following methods:
(1) rheum officinale, radix ampelopsis, the root of Dahurain angelica, cape jasmine are smashed it through 40~200 meshes, obtains medicinal powder A by weight weighing；
(2) calamine, catechu are smashed it through into 40~200 meshes by weight weighing；
(3) medicinal powder A is added after the solvent of 1000~3000 parts by weight being heated to boiling point, stirs 1~30 minute, filters off medicine
Slag is added calamine, catechu after cooling, is uniformly mixing to obtain the preparation；The solvent is selected from peanut oil, soybean oil, sesame oil
At least one of.
Optionally, the preparation is prepared using following methods:
(1) rheum officinale, radix ampelopsis, the root of Dahurain angelica and cape jasmine are smashed it through 40~200 meshes, obtains medicinal powder A by weight weighing；
(2) calamine, catechu, borneol, olibanum and myrrh are smashed it through into 40~200 meshes by weight weighing respectively；
(3) medicinal powder A is added after the solvent of 1000~3000 parts by weight being heated to boiling point, stirs 1~30 minute, filters off medicine
Slag is added calamine, catechu, borneol, olibanum and myrrh after cooling, is uniformly mixing to obtain the preparation；The solvent is selected from flower
At least one of oil generation, soybean oil, sesame oil.
Optionally, the preparation is prepared using following methods:
(1) rheum officinale, radix ampelopsis, the root of Dahurain angelica, cape jasmine and other compositions are smashed it through 40~200 meshes, obtained by weight weighing
To medicinal powder A；
(2) calamine, catechu, borneol, olibanum and myrrh are smashed it through into 40~200 meshes by weight weighing respectively；
(3) medicinal powder A is added after the solvent of 1000~3000 parts by weight being heated to boiling point, stirs 1~30 minute, filters off medicine
Slag is added calamine, catechu, borneol, olibanum and myrrh after cooling, is uniformly mixing to obtain the preparation；The solvent is selected from flower
At least one of oil generation, soybean oil, sesame oil.
The invention further relates to the Chinese medicine composition, the preparations to be used to prepare treatment diabetic foot ulcer, arteries and veins
Guan Yan festers, the application in bedsore, burn and scald or skin injury ulcer.
Technical solution of the present invention at least has following beneficial effect:
The present invention festers to diabetic foot ulcer, vasculitis through many years clinical practice verifying, bedsore, burn and scald and various skins
Skin trauma ulcer, festering etc. has extraordinary curative effect, and treatment cycle is short, and pain and the economy for significantly reducing patient are negative
Load, fester particularly with middle severe diabetic foot ulcer, vasculitis, bedsore and burn and scald and other effects it is significant.
Combined with specific embodiments below, the application is further described.It should be understood that these embodiments are merely to illustrate the application
Rather than limitation scope of the present application.
Specific embodiment
Has effects that the Chinese medicine composition of putrefaction-removing granulation-promoting the present embodiments relate to a kind of, with rheum officinale, radix ampelopsis, the root of Dahurain angelica, Cape jasmine
Son, calamine are primary raw material, can also further add borneol, olibanum and myrrh.Based on the dialectical theory of Chinese medical discrimination, knot
Many years clinical experience is closed, compatibility is reasonable, has short treating period, technical advantage quick, significant in efficacy.Wherein selected Chinese medicine group
The pharmacological action divided is as follows:
Rheum officinale: heat and toxic materials clearing away, clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow, removing dampness through diuresis and removing jaundice.It can be used for carbuncle swells furunculosis, acute appendicitis
Abdominal pain, traumatic injury；Externally treating burns and scalds.
Radix ampelopsis: clearing heat and detoxicating, carbuncle that disappears dissipating bind, expelling pus and promoting granulation.It can be used for ulcer carbuncle on the back, furunculosis, scrofula, burn and scald.
The root of Dahurain angelica: relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping, detumescence and apocenosis can be used for sore swell and ache curative.
Cape jasmine: purging intense heat relieving restlessness, clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body；Externally used detumescence analgesic.It can be used for pathogenic fire,toxin and furuncles；Torsion is controlled outside to frustrate
It is grieved.
Calamine: hygroscopic, myogenic, sore, hemostasis.Unhealing ulcer, eczema itch, scald, traumatic hemorrhage are controlled outside.
Borneol: inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain.It can be used for aphtha, abscess of throat, purulent ear canal.
Catechu: promoting blood circulation and stopping pain, hemostasia and promoting granulation, hygroscopic sore.It can be used for the pain of injury caused by falling and tumbling, traumatic hemorrhage, sore are not held back, wet
Rash, wet sore.
Olibanum: promoting blood circulation analgesic therapy, detumescence and promoting granulation.It can be used for muscle arteries and veins contraction, traumatic injury, carbuncle swells sore.
Myrrh: scattered stasis pain, detumescence and promoting granulation.It can be used for rheumatic arthralgia, traumatic injury, carbuncle swells sore.
Wherein, 50~100 parts by weight of rheum officinale, 30~60 weight of radix ampelopsis are contained in the Chinese medicine composition of the embodiment of the present invention
Part, 30~60 parts by weight of the root of Dahurain angelica, 5~20 parts by weight of cape jasmine, 10~40 parts by weight of catechu, 10~30 parts by weight of calamine；Into one
Walk preferred 40~80 parts by weight of rheum officinale, 30~40 parts by weight of radix ampelopsis, 30~45 parts by weight of the root of Dahurain angelica, 10~20 parts by weight of cape jasmine, youngster
20~30 parts by weight of tea, 15~20 parts by weight of calamine.Wherein, rheum officinale bitter cold easily causes medication portion if adding too much
The effect of discomfort of position, too low then removing pattogenic heat from the blood and toxic material from the body, plays insufficient.The effect of rheum officinale is easily influenced if radix ampelopsis adding too much, mistake
It is low, it cannot effectively play the effect of its expelling pus and promoting granulation.
Optionally, 15~50 parts by weight of borneol, 20~40 weight of olibanum are also contained in the Chinese medicine composition of the embodiment of the present invention
Measure part, 5~20 parts by weight of myrrh；30~45 parts by weight of further preferred borneol, 20~30 parts by weight of olibanum, 5~13 weight of myrrh
Measure part.
It is furthermore preferred that containing 40~80 parts by weight of rheum officinale, 30~40 weight of radix ampelopsis in the Chinese medicine composition of the embodiment of the present invention
Measure part, 30~45 parts by weight of the root of Dahurain angelica, 10~20 parts by weight of cape jasmine, 30 parts by weight of catechu, 15~20 parts by weight of calamine, borneol 45
5~15 parts by weight of parts by weight, 30~40 parts by weight of olibanum and myrrh.
Optionally, other compositions I is also contained in the Chinese medicine composition of the embodiment of the present invention, other compositions I is selected from Radix Notoginseng, treasure
At least one of pearl powder, great burdock achene, lobelia chinensis and polygonum cuspidate.The effect of this few herbs are as follows:
Radix Notoginseng: dissipating stasis and stanching bleeding, detumescence ding-tong.It can be used for traumatic hemorrhage and tumbling and swelling.
Pearl powder: arresting convulsion of calming the nerves, improving eyesight disappear screen, solve taking poison and growing muscle due, moistening skin and eliminating spot.It can be used for sore not hold back and skin splash.
Great burdock achene: dispelling wind and heat from the body, promoting the dispersing function of the lung promoting eruption, relieving sore-throat of detoxifying.It can be used for morbilli, rubeola, carbuncle sore tumefacting virus.
Lobelia chinensis: clearing heat and detoxicating, inducing diuresis to remove edema.It can be used for carbuncle swells furunculosis, snakebite and bugbite, tympanites oedema, eczema wet sore.
Polygonum cuspidate: removing dampness through diuresis and removing jaundice, clearing heat and detoxicating, removing blood stasis and acesodyne is relieving cough and reducing sputum.It can be used for jaundice with damp-heat pathogen, carbuncle sore tumefacting virus, extreme misery
Scald, traumatic injury.
Preferably, 10~20 parts by weight of Radix Notoginseng, 10~20 weight of pearl powder are contained in the Chinese medicine composition of the embodiment of the present invention
Measure part, 10~20 parts by weight of great burdock achene, 10~20 parts by weight of lobelia chinensis, 10~20 parts by weight of polygonum cuspidate.It is furthermore preferred that the present invention is real
It applies and contains 10 parts by weight of Radix Notoginseng, 15 parts by weight of pearl powder, 15 parts by weight of great burdock achene, 20 weight of lobelia chinensis in the Chinese medicine composition of example
Part, 10 parts by weight of polygonum cuspidate.
Optionally, in the Chinese medicine composition of the embodiment of the present invention also contain other compositions II, other compositions II be selected from Radix Angelicae Sinensis,
At least one of radix scrophulariae, asarum, polygonum cuspidate, safflower, dragon's blood and calcined gypsum.The effect of this few herbs are as follows:
Radix Angelicae Sinensis: replenishing and activating blood, regulating menstruation and relieving pain, moistening intestines and relaxing bowels.It can be used for injury from falling down and ulcer sores.
Radix scrophulariae: clearing heat and cooling blood, nourishing yin and lessening fire, detoxicating and resolving a mass.It can be used for heat and enter ying blood, febrile virulent maculae, carbuncle sore tumefacting virus.
Asarum: relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping is sensible, warming lung and resolving fluid.Asarum pungent-warm dissipates wet promoting blood circulation, then the heresy of skin and flesh muscles and bones
Dissipate more, there is the benefits of myogenic.
Polygonum cuspidate: removing dampness through diuresis and removing jaundice, clearing heat and detoxicating, removing blood stasis and acesodyne is relieving cough and reducing sputum.It can be used for jaundice with damp-heat pathogen, carbuncle sore tumefacting virus, extreme misery
Scald, traumatic injury.
Safflower: blood circulation, removing blood stasis and acesodyne.Ke Yong Yu abdominal mass and lump, injury from falling down, sore swell and ache curative.
Dragon's blood: promoting blood circulation analgesic therapy, removing blood stasis and hemostasis, myogenic sore.For traumatic injury, trusted subordinate's stasis caused pain, traumatic hemorrhage, sore is not
It holds back.
Calcined gypsum: hygroscopic, myogenic, sore, hemostasis.Unhealing ulcer, eczema itch, scald, traumatic hemorrhage are controlled outside.
It is further alternative, in the Chinese medicine composition of the embodiment of the present invention containing 10~20 parts by weight of Radix Angelicae Sinensis, asarum 10~
20 parts by weight, 10~20 parts by weight of polygonum cuspidate, 10~20 parts by weight of dragon's blood, 10~20 parts by weight of calcined gypsum.Preferably, the present invention is real
Apply in the Chinese medicine composition of example also containing 10 parts by weight of Radix Angelicae Sinensis, 15 parts by weight of asarum, 20 parts by weight of polygonum cuspidate, 10 parts by weight of dragon's blood,
10 parts by weight of calcined gypsum.
It is further alternative, 10~20 parts by weight of Radix Angelicae Sinensis, radix scrophulariae 10 are also contained in the Chinese medicine composition of the embodiment of the present invention
~20 parts by weight, 10~20 parts by weight of safflower, 10~20 parts by weight of calcined gypsum.Preferably, the Chinese traditional medicine composition of the embodiment of the present invention
Contain 20 parts by weight of Radix Angelicae Sinensis, 10 parts by weight of radix scrophulariae, 15 parts by weight of safflower, 10 parts by weight of calcined gypsum in object.
The present invention passes through a large amount of clinical practices, determines that ingredients matches.Each medicinal material function complements each other, and matches proper side
Drug effect can be given full play to, single dosage is excessive or too small will affect overall effect.
The second aspect of the embodiment of the present invention proposes a kind of preparation of Chinese medicine composition, the dosage form of preparation be ointment,
Paste, finish, paint, patch, emplastrum or film.
Wherein, ointment refers to the semisolid external application system with certain consistency that drug and appropriate substrate are uniformly mixed
Agent, common matrix are divided into oil, water-soluble and emulsion-type matrix.Paste is a kind of semisolid paste-like preparation, by mealy medicine
It is mixed with matrix, can soften under external application body temperature and non-fusible, can be maintained for a long time on the skin.Paste has oil paste
Two class of agent and W Sol P, it is oil to use vaseline, atoleine, lanolin, fat oil etc. for matrix.Finish is with plant
Oily (soya-bean oil, sesame oil, peanut oil, castor oil) or mineral oil (atoleine) are that solvent is mixed into dosage form made of insoluble medicinal powder.
Patch means Pasting on the skin, and drug can produce a kind of systemic or local action laminar preparation.Emplastrum is meant
Paste is made in material medicine and suitable matrix, is coated on back lining materials and is sticked for skin, can produce systemic or office
A kind of laminar preparation of portion's effect.Film means material medicine and the processed manufactured film-like preparation of suitable filmogen.
Paint means aqueous or oily solution, emulsion, suspension containing material medicine, soft for antiseptic gauze before use or cotton balls etc.
Softer material dips the liquid preparation for being applied to skin or oral cavity and throat's mucous membrane, can also be that solution is made with sterile vehicle before use
Sterile freeze-drying preparation is smeared for wound face and is treated.
Wherein, also contain auxiliary material in preparation, auxiliary material in solvent, ointment bases, filmogen, cream auxiliary material processed at least
It is a kind of；Solvent is selected from least one of peanut oil, soybean oil, sesame oil；Ointment bases is selected from lanolin, vaseline, beeswax, stone
At least one of wax, Chinese wax；Filmogen is in polyvinyl alcohol, acrylic resin, cellulose family macromolecule material
It is at least one；Cream auxiliary material processed is selected from least one of red lead, lead powder.
Optionally, the preparation of the embodiment of the present invention is prepared using following methods:
(1) rheum officinale, radix ampelopsis, the root of Dahurain angelica, cape jasmine are smashed it through 40~200 meshes, obtains medicinal powder A by weight weighing；Its
In can will rheum officinale, radix ampelopsis, the root of Dahurain angelica, cape jasmine mix after crush, mixed again after can also crushing respectively it；
(2) calamine, catechu are smashed it through into 40~200 meshes by weight weighing；
(3) medicinal powder A is added after the solvent of 1000~3000 parts by weight being heated to boiling point, stirs 1~30 minute, filters off medicine
Slag is added calamine, catechu after cooling, is uniformly mixing to obtain the preparation of Chinese medicine composition.
Wherein, if amount of solvent is excessive, preparation is excessively dilute, then active constituent content is insufficient, cannot play medicine well
Effect, if amount of solvent is too small, effective ingredient is extracted not exclusively, not only causes the waste of medicinal material, but also is influenced effective
The proportion of ingredient, to influence drug effect.
Optionally, the preparation of the embodiment of the present invention is prepared using following methods:
(1) rheum officinale, radix ampelopsis, the root of Dahurain angelica and cape jasmine are smashed it through 40~200 meshes, obtains medicinal powder A by weight weighing；
It crushes after can wherein rheum officinale, radix ampelopsis, the root of Dahurain angelica, cape jasmine being mixed, is mixed again after can also crushing respectively it；
(2) calamine, catechu, borneol, olibanum and myrrh are smashed it through into 40~200 meshes by weight weighing respectively；
(3) medicinal powder A is added after the solvent of 1000~3000 parts by weight being heated to boiling point, stirs 1~30 minute, filters off medicine
Slag is added calamine, catechu, borneol, olibanum and myrrh after cooling, is uniformly mixing to obtain preparation.
Optionally, the preparation of the embodiment of the present invention is prepared using following methods:
(1) rheum officinale, radix ampelopsis, the root of Dahurain angelica, cape jasmine and other compositions are smashed it through 40~200 meshes, obtained by weight weighing
To medicinal powder A；It is crushed after can wherein rheum officinale, radix ampelopsis, the root of Dahurain angelica, cape jasmine, other compositions being mixed, after can also crushing respectively it
It is mixed again；Other compositions can be selected from other compositions I or other compositions II；
(2) calamine, catechu, borneol, olibanum and myrrh are smashed it through into 40~200 meshes by weight weighing respectively；
(3) medicinal powder A is added after the solvent of 1000~3000 parts by weight being heated to boiling point, stirs 1~30 minute, filters off medicine
Slag is added calamine, catechu, borneol, olibanum and myrrh after cooling, is uniformly mixing to obtain preparation.
The embodiment of the present invention also proposes that the Chinese medicine composition, said preparation are being used to prepare treatment diabetic foot ulcer, vascular
Inflammation festers, the application in bedsore, burn and scald or skin injury ulcer.
The usage and dosage of preparation of the embodiment of the present invention are as follows: after the cleaning surface of a wound, even spread or affected part is pasted on, according to the state of an illness
And dosage form, for example liquid preparations such as finish, paint can be dressing 2~3 times daily, for example the semisolid preparations such as ointment, patch, can
Daily dressing 1 time or the next day dressing 1 time.
Embodiment 1:
A kind of Chinese materia medica preparation of putrefaction-removing granulation-promoting, is made of the raw material of following parts by weight: 40 parts of rheum officinale, 30 parts of radix ampelopsis, the root of Dahurain angelica
45 parts, 10 parts of cape jasmine, 10 parts of Radix Notoginseng, 15 parts of pearl powder, 15 parts of great burdock achene, 20 parts of lobelia chinensis, 10 parts of polygonum cuspidate, 45 parts of borneol, furnace
20 parts of sweet stone, 30 parts of catechu, 40 parts of olibanum, 5 parts of myrrh.
The Chinese materia medica preparation of the present embodiment the preparation method is as follows:
The rheum officinale of above-mentioned parts by weight, radix ampelopsis, the root of Dahurain angelica, cape jasmine, Radix Notoginseng, pearl powder, great burdock achene, lobelia chinensis, polygonum cuspidate are mixed
40 meshes are smashed it through, medicinal powder A is obtained；Borneol, calamine, catechu, olibanum, myrrh are smashed it through into 80 meshes respectively；By solvent
Be heated to boiling, medicinal powder A be added into solvent, continue heating 30 minutes, filter off the dregs of a decoction, be added after cooling borneol, calamine,
Catechu, olibanum, myrrh stir evenly the finish to get putrefaction-removing granulation-promoting.Solvent is 2000 parts of sesame oil.
Embodiment 2:
A kind of Chinese materia medica preparation of putrefaction-removing granulation-promoting, the raw material comprising following parts by weight: 80 parts of rheum officinale, 40 parts of radix ampelopsis, the root of Dahurain angelica 30
Part, 20 parts of cape jasmine, 20 parts of Radix Angelicae Sinensis, 15 parts of asarum, 20 parts of polygonum cuspidate, 10 parts of dragon's blood, 45 parts of borneol, 10 parts of calcined gypsum, calamine 15
Part, 30 parts of catechu, 30 parts of olibanum, 15 parts of myrrh.
The Chinese materia medica preparation of the present embodiment the preparation method is as follows:
The rheum officinale of above-mentioned parts by weight, radix ampelopsis, the root of Dahurain angelica, cape jasmine, Radix Angelicae Sinensis, asarum, polygonum cuspidate, dragon's blood are smashed it through 200 respectively
Mesh mixes to obtain medicinal powder A；Borneol, calcined gypsum, calamine, catechu, olibanum, myrrh are smashed it through into 200 meshes respectively；It will be molten
Agent is heated to boiling, and medicinal powder A is added into solvent, continues heating stirring 20 minutes, filters off the dregs of a decoction, and ointment bases is added, stirs
It mixes uniformly, borneol, calcined gypsum, calamine, catechu, olibanum, myrrh is added after cooling, stirs evenly to get the soft of putrefaction-removing granulation-promoting
Cream.Solvent is 1500 portions of peanut oil, and ointment bases is the vaseline of 100 parts by weight.
Embodiment 3:
A kind of Chinese materia medica preparation of putrefaction-removing granulation-promoting, the raw material comprising following parts by weight: 80 parts of rheum officinale, 40 parts of radix ampelopsis, the root of Dahurain angelica 30
Part, 20 parts of cape jasmine, 20 parts of Radix Angelicae Sinensis, 10 parts of radix scrophulariae, 15 parts of safflower, 45 parts of borneol, 10 parts of calcined gypsum, 15 parts of calamine, catechu 30
Part, 30 parts of olibanum, 15 parts of myrrh.
The Chinese materia medica preparation of the present embodiment the preparation method is as follows:
The rheum officinale of above-mentioned parts by weight, radix ampelopsis, the root of Dahurain angelica, cape jasmine, Radix Angelicae Sinensis, radix scrophulariae, safflower are smashed it through into 200 meshes respectively,
Mix to obtain medicinal powder A；Borneol, calcined gypsum, calamine, catechu, olibanum, myrrh are smashed it through into 200 meshes respectively；Solvent is heated
To boiling, medicinal powder A is added into solvent, is continued heating stirring 20 minutes, the dregs of a decoction are filtered off, ointment bases is added, stirs evenly,
Borneol, calcined gypsum, calamine, catechu, olibanum, myrrh are added when temperature is down to about 50 DEG C, stirs evenly, ointment is poured into and is put
Have in the container of antiseptic gauze, up to the yarn cream item of putrefaction-removing granulation-promoting after solidification to be cooled.Solvent is 1000 parts of sesame oil, ointment bases
For the beeswax of 75 parts by weight and the lanolin of 15 parts by weight.
Experimental example 1
The present invention is applied in civil clinic, in received 30 angiitis sore patients, average age 48.2 years old, uses this
The preparation of inventive embodiments 1, daily dressing 2~3 times.
After 3 months, obtained experimental result is as shown in table 1:
Table 1
The standard of curative effect evaluation is as follows:
Cure: patient symptom completely disappears, the speed of travel 110 step per minute or so, and walking does not occur not more than 1500 meters
It is suitable；
Effective: patient symptom improves, walking 110 step per minute, and walking does not occur discomfort more than 500 meters；
Effective: patient symptom improves slightly, and 110 step of walking is per minute, and walking does not occur discomfort more than 300 meters；
It is invalid: not up to above-mentioned standard or exacerbation.
Experimental example 2
Prepare diabetic foot ulcer animal model:
Using rats by intraperitoneal injection streptozotocin induced diabetes, 24 successful diabetes rats of induction are screened, are adopted
2 round full thickness skins are prepared in the nape of the neck backbone two sides symmetric position with full thickness skin cutting method and cut off wound, are given respectively
Give the preparation and blank ointment of the embodiment of the present invention 2, daily dressing 1 time.
Metrics evaluation: body weight growth rate, wound healing rate and pathological examination.
After 2 weeks, obtained experimental result is as shown in table 2:
Table 2
Experimental example 3
Prepare bedsore animal model:
Using SD rat, every angel its ischemic 2h in such a way that magnetic sheet is oppressed, Reperfu- sion 0.5h, continuous 5 circulations, and
Continuous action 4 days, rat back bedsore model is prepared, screening is randomly divided into 2 groups, is given respectively with modeling successful rat 36
Give preparation and the blank control of the embodiment of the present invention 3, daily dressing 2 times.
Evaluation index: body weight growth rate and wound healing rate.
After 18 days, obtained experimental result is as shown in table 3:
Table 3
| As a result # | Embodiment 3 | Blank control |
| Body weight growth rate # | 1.3% | 1.6% |
| Wound healing rate # | 92.4% | 68.2% |
Experimental example 4
Comparative formulation 1: preparing preparation according to the method for embodiment 2, and difference is only that in the Chinese materia medica preparation that not add furnace sweet
Stone.
Comparative formulation 2: preparation is prepared according to the method for embodiment 2, difference is only that in formulation process, solvent is
4000 portions of peanut oil.
Comparative formulation 3: preparation is prepared according to the method for embodiment 2, difference is only that in formulation process, solvent is
600 portions of peanut oil.
Comparative formulation 4: preparation is prepared according to the method for embodiment 2, difference is only that calamine addition 5 in the Chinese materia medica preparation
Parts by weight.
Comparative formulation 5: preparation is prepared according to the method for embodiment 2, difference is only that rheum officinale addition 120 in the Chinese materia medica preparation
Parts by weight.
Comparative formulation 6: preparation is prepared according to the method for embodiment 2, difference is only that radix ampelopsis addition 10 in the Chinese materia medica preparation
Parts by weight, the root of Dahurain angelica add 10 parts by weight.
Preparation scald animal model:
96 SD rats are chosen, rat skin is scalded using 94 DEG C of vapor (steam) temperature, cause injury time 8s, forms deep II
Spend scald wound.It is randomly divided into 7 groups, every group 20.First group of preparation using the embodiment of the present invention 2, second group uses this hair
The preparation of bright Comparative formulation 1, for third group using the preparation of Comparative formulation 2 of the present invention, the 4th group uses Comparative formulation 3 of the present invention
Preparation, the 5th group of preparation using Comparative formulation 4 of the present invention, the 6th group of preparation using Comparative formulation 5 of the present invention, the 7th group makes
With the preparation of Comparative formulation 6 of the present invention, the 8th group of blank control using the embodiment of the present invention 2, daily dressing 2 times.
Metrics evaluation: body weight growth rate, wound healing rate and pathological examination.
It is as shown in table 4 using the experimental result obtained after 2 weeks:
Table 4
It is not for limiting claim, any this field skill although the application is disclosed as above with preferred embodiment
Art personnel without departing from the concept of this application, can make several possible variations and modification, therefore the application
Protection scope should be subject to the range that the claim of this application is defined.
Claims (10)
1. a kind of have effects that the Chinese medicine composition of putrefaction-removing granulation-promoting, which is characterized in that containing with the following group in the Chinese medicine composition
Point:
50~100 parts by weight of rheum officinale, 30~60 parts by weight of radix ampelopsis, 30~60 parts by weight of the root of Dahurain angelica, 5~20 parts by weight of cape jasmine, catechu
10~40 parts by weight, 10~30 parts by weight of calamine.
2. Chinese medicine composition according to claim 1, which is characterized in that also contain borneol, cream in the Chinese medicine composition
Fragrant and myrrh:
Preferably, 15~50 parts by weight of borneol, 20~40 parts by weight of olibanum, myrrh 5~20 are also contained in the Chinese medicine composition
Parts by weight；
It is furthermore preferred that containing 40~80 parts by weight of rheum officinale, 30~40 parts by weight of radix ampelopsis, the root of Dahurain angelica 30~45 in the Chinese medicine composition
Parts by weight, 10~20 parts by weight of cape jasmine, 20~30 parts by weight of catechu, 15~20 parts by weight of calamine, 30~45 parts by weight of borneol,
5~15 parts by weight of 30~40 parts by weight of olibanum and myrrh.
3. Chinese medicine composition according to claim 1 or 2, which is characterized in that also contain other in the Chinese medicine composition
Ingredient I, the other compositions I are selected from least one of Radix Notoginseng, pearl powder, great burdock achene, lobelia chinensis and polygonum cuspidate；
Preferably, 10~20 parts by weight of Radix Notoginseng, 10~20 parts by weight of pearl powder, great burdock achene 10 are also contained in the Chinese medicine composition
~20 parts by weight, 10~20 parts by weight of lobelia chinensis, 10~20 parts by weight of polygonum cuspidate；
It is furthermore preferred that also containing 10 parts by weight of Radix Notoginseng, 15 parts by weight of pearl powder, 15 weight of great burdock achene in the Chinese medicine composition
Part, 20 parts by weight of lobelia chinensis, 10 parts by weight of polygonum cuspidate.
4. Chinese medicine composition according to claim 1 or 2, which is characterized in that also contain other in the Chinese medicine composition
Ingredient II, the other compositions II are selected from least one of Radix Angelicae Sinensis, radix scrophulariae, asarum, polygonum cuspidate, safflower, dragon's blood and calcined gypsum；
Preferably, 10~20 parts by weight of Radix Angelicae Sinensis, 10~20 parts by weight of asarum, polygonum cuspidate 10~20 are also contained in the Chinese medicine composition
Parts by weight, 10~20 parts by weight of dragon's blood, 10~20 parts by weight of calcined gypsum；Work as it is furthermore preferred that also containing in the Chinese medicine composition
Return 10 parts by weight, 15 parts by weight of asarum, 20 parts by weight of polygonum cuspidate, 10 parts by weight of dragon's blood, 10 parts by weight of calcined gypsum；
Preferably, 10~20 parts by weight of Radix Angelicae Sinensis, 10~20 parts by weight of radix scrophulariae, safflower 10~20 are also contained in the Chinese medicine composition
Parts by weight, 10~20 parts by weight of calcined gypsum；It is furthermore preferred that also containing 20 parts by weight of Radix Angelicae Sinensis, radix scrophulariae 10 in the Chinese medicine composition
Parts by weight, 15 parts by weight of safflower, 10 parts by weight of calcined gypsum.
5. such as the preparation of the described in any item Chinese medicine compositions of Claims 1 to 4, which is characterized in that the dosage form of the preparation is
Ointment, paste, finish, paint, patch, emplastrum or film.
6. preparation according to claim 5, which is characterized in that also contain auxiliary material in the preparation, the auxiliary material is selected from molten
At least one of agent, ointment bases, filmogen, cream auxiliary material processed；
The solvent is selected from least one of peanut oil, soybean oil, sesame oil；The ointment bases be selected from lanolin, vaseline,
At least one of beeswax, paraffin, Chinese wax；The filmogen is selected from polyvinyl alcohol, acrylic resin, cellulose family high score
At least one of sub- material；The cream auxiliary material processed is selected from least one of red lead, lead powder.
7. preparation according to claim 5, which is characterized in that the preparation is prepared using following methods:
(1) rheum officinale, radix ampelopsis, the root of Dahurain angelica, cape jasmine are smashed it through 40~200 meshes, obtains medicinal powder A by weight weighing；
(2) calamine, catechu are smashed it through into 40~200 meshes by weight weighing；
(3) medicinal powder A is added after the solvent of 1000~3000 parts by weight being heated to boiling point, stirs 1~30 minute, filters off the dregs of a decoction,
Calamine, catechu are added after cooling, is uniformly mixing to obtain the preparation；The solvent is in peanut oil, soybean oil, sesame oil
It is at least one.
8. preparation according to claim 5, which is characterized in that the preparation is prepared using following methods:
(1) rheum officinale, radix ampelopsis, the root of Dahurain angelica and cape jasmine are smashed it through 40~200 meshes, obtains medicinal powder A by weight weighing；
(2) calamine, catechu, borneol, olibanum and myrrh are smashed it through into 40~200 meshes by weight weighing respectively；
(3) medicinal powder A is added after the solvent of 1000~3000 parts by weight being heated to boiling point, stirs 1~30 minute, filters off the dregs of a decoction,
Calamine, catechu, borneol, olibanum and myrrh are added after cooling, is uniformly mixing to obtain the preparation；The solvent is selected from peanut
At least one of oil, soybean oil, sesame oil.
9. preparation according to claim 5, which is characterized in that the preparation is prepared using following methods:
(1) rheum officinale, radix ampelopsis, the root of Dahurain angelica, cape jasmine and other compositions are smashed it through 40~200 meshes, obtains medicine by weight weighing
Powder A；
(2) calamine, catechu, borneol, olibanum and myrrh are smashed it through into 40~200 meshes by weight weighing respectively；
(3) medicinal powder A is added after the solvent of 1000~3000 parts by weight being heated to boiling point, stirs 1~30 minute, filters off the dregs of a decoction,
Calamine, catechu, borneol, olibanum and myrrh are added after cooling, is uniformly mixing to obtain the preparation；The solvent is selected from peanut
At least one of oil, soybean oil, sesame oil.
10. existing such as the described in any item Chinese medicine compositions of Claims 1 to 4 or such as the described in any item preparations of claim 5~9
It is used to prepare treatment diabetic foot ulcer, vasculitis is festered, the application in bedsore, burn and scald or skin injury ulcer.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111419955A (en) * | 2020-05-26 | 2020-07-17 | 林和全 | Plaster for treating wound ulceration and surgical ulcer caused by venomous snake bite and preparation method thereof |
| CN113440576A (en) * | 2021-07-26 | 2021-09-28 | 刘质友 | Medicine for treating scald and its preparing process |
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| CN111419955B (en) * | 2020-05-26 | 2021-12-21 | 林和全 | Plaster for treating wound ulceration and surgical ulcer caused by venomous snake bite and preparation method thereof |
| CN113440576A (en) * | 2021-07-26 | 2021-09-28 | 刘质友 | Medicine for treating scald and its preparing process |
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