CN1044048A - Absorbable slow-solution medicinal membrane and preparation method thereof - Google Patents
Absorbable slow-solution medicinal membrane and preparation method thereof Download PDFInfo
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- CN1044048A CN1044048A CN 90100300 CN90100300A CN1044048A CN 1044048 A CN1044048 A CN 1044048A CN 90100300 CN90100300 CN 90100300 CN 90100300 A CN90100300 A CN 90100300A CN 1044048 A CN1044048 A CN 1044048A
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Abstract
The present invention relates to a kind of absorbable slow-solution medicinal membrane and preparation method thereof, it utilizes can be made carrier by the gelatin that human body absorbs fully, carry last various effective medicines and slow releasing agent formaldehyde and make the medicine film, this medicine film places in the tissue, long period discharges medicine in tissue, absorb carrier simultaneously, form effective treatment concentration in the part, thereby reach the purpose of treatment.
The present invention is simple, and cost is low, the curative effect height, and it not only is suitable for the treatment of body surface illness, and chronic disease disease of illness in deep tissue and the tract and body cavity inside etc. is had significant curative effect.
Description
The present invention relates to medicine film, particularly a kind of absorbable slow-solution medicinal membrane and preparation method thereof.It utilizes can be made carrier by the gelatin that tissue absorbs fully, carries and goes up various effective medicines, places in the tissue, when tissue discharges medicine, absorbs carrier, reaches the purpose of treatment.
The local illness such as cancer that shift and can't excise in common clinically infection, postoperative wound, long-term chronic ulcer, the tumor body cavity, all adopt systemic administration and part change dressings operation and method etc. at present both at home and abroad, these therapy dosages are big, it is little to arrive partial dosage, curative effect is slow, it is many to pay reaction, and patient often is difficult to accept.Therefore, how to shorten the course of treatment, quicken control disease, promote the human body early recovery, become the problem that present the world of medicine pays close attention to.
At the problems referred to above, before the present invention proposes, the method of the above-mentioned illness of medication film (membrane) treatment is arranged, and the kind of medicine film is a lot of at present, sees pharmacopeia (version in 1985) chapter 10, they adopt polyvinyl alcohol (PVA) to make carrier mostly, the medicine film toughness of making is poor, is difficult to be absorbed fully by human body, is only limited to treatment of diseases in body surface organization or some tract, and for the treatment of organizing wound and chronic disease in illness, the body cavity deeply, its effect is not remarkable.
Purpose of the present invention is very clear and definite, exactly in order to solve the deficiency that above-mentioned existing medicine film exists, and provide a kind of various antibiotic and various water soluble drug are mixed in the carrier gelatin, make various absorbable slow-solution medicinal membranes and preparation method thereof, make it can treat in the dark tissue of human body effectively and illness and endoceliac illness in the tract with different purposes.
Principle of the present invention is that to select the medical agent that can be absorbed fully by human body for use be carrier, add with carrier mix the most frequently used clinically oral, inject effective medicine, add certain slow releasing agent, make it be oriented to the part, beginning discharges with high concentration, keeps stable slow release later on, in the focus part, it can be eliminated effectively or suppress pathogenic bacterium, makes tissue repair and regeneration.
The present invention selects for use viscosity more than 20%, and is impure low, and the gelatin that meets pharmacopeia (version in 1985) is as carrier.Medicine adopts gentamycin, rifampicin, metronidazole, tetracycline, 5F uracil, amycin etc., and Chinese medicine.
Preparation method of the present invention is to make solvent (Powdered medicine need be dissolved in the distilled water earlier) with the pastille aqueous solution.Every 4ml～8ml solvent adds gelatin 1 gram, and gelatin is added in the solvent, places container to soak 10～16 hours, and soaking temperature is fixed according to the character of medicine, is advisable with the temperature of not destroying the medicine characteristic, generally selects 4～10 ℃ temperature.Place constant water bath box to be warming up to 70～90 ℃ after the immersion again, water bath heat preservation 20～30 minutes makes medicine fully mix with gelatin, and is to be cooled during to 32 ℃～40 ℃, adds slow releasing agent formaldehyde and stirs evenly.Make concentration to 0.5～3% of formaldehyde in the above-mentioned mixed solution.Then with the drips of solution for preparing on the tabula rasa of drying machine, make the medicine film that required form, size, thickness do not wait, plugged in 10 minutes, pull out power supply and treat to plug again after 10 minutes, so repeatedly, till medicine film bone dry can come off voluntarily.Some medicine is not suitable for using electrical heating, only needs to drip in drying on the machine tabula rasa, dries up, dries in the shade, and comes off after treating to do voluntarily.
The medicine film of making is packed in the plastic bag, opens wide bag mouth, place formalin to smoke case and smoked 30 minutes to 1 hour, take out seal after, packing finishes.
From said method as can be seen, the present invention has the following advantages and good effect:
1. can the long period slowly discharge medicine effectively, make the local dose that keeps higher concentration, and systemic concentrations be low, pair reaction that reduces and avoid systemic administration to cause.
2. absorbable slow-solution medicinal membrane can be cultivated and the drug sensitive experiment result according to patient's focal organism owing to can mix multiple different medicine, selects optimal drug for use, and curative effect is more remarkable.
3. select for use gelatin good, when discharging medicine, can be organized absorption well fully, the effect that promotes wound healing and reparation is arranged as its histocompatibility of carrier.
4. using this kind medicine film does not need change dressings every day, promptly save dressing and also alleviate patient's economy, time, spiritual burden, the method is simple, cost is low, the curative effect height, and it is fit to common clinically infection, postoperative wound, long-term chronic ulcer, the local transfer in the tumor body cavity, and the treatment of the illness such as cancer that can't excise, and significant curative effect is arranged.
In order further to confirm the effect of this medicine film, we have carried out antibacterial action to it, release concentration and slow release effective time, and the research of acute toxicity test and histocompatibility, result of study has confirmed the reliability and the practicality of this medicine film.
Describe the present invention in detail below in conjunction with embodiment.
Embodiment 1, antibiotics medicine film (gentamycin, metronidazole, rifampicin, isoniazid etc.) are example with gentamycin medicine film:
Prescription:
Gentamycin 1,600 ten thousand
u400 milliliters
Gelatin 40 grams
8 milliliters in 10% formaldehyde
Technology:
Gelatin 40 grams are put into 400 milliliters of gentamycins, place in 4 ℃ the refrigerator, soak after 12 hours and take out, 80 ℃ of warming-in-water, water bath heat preservation is 30 minutes then, treat after 32 ℃ to add 8 milliliters in 10% formaldehyde, then it is dropped in and make every medicine film size on the tabula rasa of the machine of drying and be the garden type of diameter 2.5cm, thick 0.2mm, contain gentamycin 40,000
u, gelatin 0.1 gram, the slow-release medicine-membrane that 10% formaldehyde is 0.02 milligram.
Using method:
Open plastic bag, take out the medicine film with asepsis, drip normal saline on film, film gets final product deliquescing about one minute, immediately it is affixed on the clean wound.Fistula then is rolled into tubular with film and fills in this way, is used for fresh clean wound, does not change film every day, only drips several saline on film, and the messenger drug film absorbs and discharge medicine easily.
Embodiment 2, granulation promoting medicine film
Prescription:
Myrrha 300 gram Olibanums 300 gram Calaminas 450 grams
100 milliliters in gelatin 625 grams 10% formaldehyde
Technology:
Myrrha 300 grams, after Olibanum 300 grams were decocted first 30 minutes, drop into Calamina 450 grams and fry in shallow oil 5000 milliliters of medicine juice of taking-up, filtration after 20 minutes, add gelatin 625 grams, place 4 ℃ interior immersion of refrigerator to take out in 12 hours, warming-in-water to 80 ℃, water bath heat preservation is 30 minutes then, adds 100 milliliters in 10% formaldehyde in the time of 32 ℃ to be cooled.Then with it on tabula rasa, need not heat, dry in the shade, dry up and be advisable.Its medicine film size, thickness are identical with gentamycin medicine film.
Using method is identical with gentamycin medicine film.As be used for gynecological's cervical erosion, and use the saline cotton balls and clean rotten to the corn face, film directly is affixed on cervix uteri, paste once every other day, be a course of treatment with 5～10 times.
Embodiment 3, medicine membrane of oral cavity
Prescription:
150 milliliters of VitB of 0.5% metronidazole
2200 milligrams
3 milliliters in 3 milliliters of gelatin of Mel, 10 grams, 10% formaldehyde
Technology:
With vitB
2Be dissolved in 0.5% metronidazole and the Mel, add gelatin 10 grams, place in 4 ℃ of refrigerators and soaked 12 hours, warming-in-water to 80 ℃, water bath heat preservation is 30 minutes then, 3 milliliters in 10% formaldehyde that adds during to 32 ℃ to be cooled.At last it is dried in tabula rasa, make every 1cm * 1cm size, contain the medicine film of 5 milliliters of metronidazoles.
Using method: be affixed on the ulcer place.
Embodiment 4, antineoplastic agent film (is example with 5-F uracil medicine film)
Prescription:
5000 milligrams of (100 milliliters) gelatin of 5F pyrimidine, 20 grams
1 milliliter in 10% formaldehyde
Technology:
Gelatin 20 gram is put into 100 milliliters 5F uracil, place in 4 ℃ of refrigerators and soaked 12 hours, warming-in-water to 80 ℃, water bath heat preservation is 30 minutes then, and is to be cooled during to 32 ℃, adds 1 milliliter in 10% formaldehyde.At last it is dried on tabula rasa.According to the situation of clinical foci, make the medicine film of required size, thickness, content of dispersion.
Using method: be used for abdominal operation, the metastasis of remaining cancer, stump place and body surface.Be affixed on partial metastasis place.
Claims (1)
1, a kind of absorbable slow-solution medicinal membrane and preparation method thereof, adopt viscosity more than 20%, the gelatin that meets pharmacopeia (version in 1985) requirement is made carrier, it is characterized in that: it is to make solvent with medicinal liquid, per 4～8ml solvent adds gelatin 1 gram, gelatin is put into drug solvent, soaked 10～16 hours, place the water-soluble case of constant temperature to be warming up to 70～90 ℃ again, water bath heat preservation is 20～30 minutes then, to be cooled during to 32 ℃～40 ℃, add the concentration of slow release fixative formaldehyde to 0.5～3%, at last it is made the medicine film on tabula rasa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 90100300 CN1028486C (en) | 1990-01-19 | 1990-01-19 | Absorbable slow-solution medicinal membrane and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 90100300 CN1028486C (en) | 1990-01-19 | 1990-01-19 | Absorbable slow-solution medicinal membrane and preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1044048A true CN1044048A (en) | 1990-07-25 |
| CN1028486C CN1028486C (en) | 1995-05-24 |
Family
ID=4876580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 90100300 Expired - Fee Related CN1028486C (en) | 1990-01-19 | 1990-01-19 | Absorbable slow-solution medicinal membrane and preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1028486C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1052915C (en) * | 1995-11-27 | 2000-05-31 | 中国医学科学院生物医学工程研究所 | Medical carrier of protein coat for carrying gene and its prodn. method |
| CN109432245A (en) * | 2019-01-03 | 2019-03-08 | 北京诺康达医药科技股份有限公司 | It is a kind of to have effects that the Chinese medicine composition of putrefaction-removing granulation-promoting, preparation and application |
| CN109745354A (en) * | 2019-03-28 | 2019-05-14 | 叶绿芝生物科技（中山）有限公司 | A kind of dental ulcer treatment agent |
-
1990
- 1990-01-19 CN CN 90100300 patent/CN1028486C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1052915C (en) * | 1995-11-27 | 2000-05-31 | 中国医学科学院生物医学工程研究所 | Medical carrier of protein coat for carrying gene and its prodn. method |
| CN109432245A (en) * | 2019-01-03 | 2019-03-08 | 北京诺康达医药科技股份有限公司 | It is a kind of to have effects that the Chinese medicine composition of putrefaction-removing granulation-promoting, preparation and application |
| CN109745354A (en) * | 2019-03-28 | 2019-05-14 | 叶绿芝生物科技（中山）有限公司 | A kind of dental ulcer treatment agent |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1028486C (en) | 1995-05-24 |
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