CN100531746C - Medicine for treating frostbite and its preparation and use - Google Patents
Medicine for treating frostbite and its preparation and use Download PDFInfo
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- CN100531746C CN100531746C CNB2006100202846A CN200610020284A CN100531746C CN 100531746 C CN100531746 C CN 100531746C CN B2006100202846 A CNB2006100202846 A CN B2006100202846A CN 200610020284 A CN200610020284 A CN 200610020284A CN 100531746 C CN100531746 C CN 100531746C
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- chilblain
- chinese mugwort
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- folium artemisiae
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Abstract
The present invention provides new use of moxa and one kind of medicine for treating frostbite and its preparation process. The medicine is prepared with moxa or its extract, honey and other material. The medicine has obvious and fast effect of healing frostbite, and no side effect.
Description
Technical field
The new purposes that the present invention relates to end also relates to a kind of prescription for the treatment of chilblain, and specifically, this prescription is to be the medicament that feedstock production forms with natural drug Chinese mugwort, Mel etc., belongs to field of medicaments.
Background technology
Chilblain is meant under cold moist condition, and the slight cold injury that the local skin of exposures place such as acral, ear nose occurs is a kind of commonly encountered diseases, frequently-occurring disease.It is the principal element of chilblain morbidity that cold humidity or weather change suddenly.Chilblain is mainly in winter and by the cold early spring of warming, the patient is many to fall ill at the beginning of the winter, and the early spring, disease took a turn for the better, and easily recur the coming year, and severe patient is perplexed by this disease all throughout the year.The inventor is located in highland and severe cold area (Ganzi, Sichuan, Aba area), it is winter climate that more than half time is arranged the whole year approximately, even some areas are in winter climate the whole year, and such cold-damp weather makes chilblain very serious in the locality morbidity, and the cold injury degree is also serious than other city of China, area.According to incompletely statistics, global chilblain morbidity crowd is about 23.8 hundred million; China chilblain morbidity crowd is about more than 400,000,000, and the coastal area sickness rate is about 10～15%, and ground sickness rate such as the Northeast, Tibet, Qinghai, Xinjiang are about 84%.
Chilblain morbidity majority be during because of cold weather warming improper, medicated clothing ventilative bad, wear footwear uncomfortable or cold season still in inducements such as outdoor activity is too much, the generation that causes poor blood circulation to cause chilblains.Relatively poor because of the blood circulation of hands, foot or auricular concha end, the back of the hand, the finger outside, heel, external ear are the chilblain predilection site, can involve nose and shank bottom sometimes, have symmetry to distribute mostly, slowly morbidity.After the cold injury, because of the blood stagnation of local subcutaneous capillary vessel, histanoxia, vascular damaged causes that the capillary vessel permeability increases, exudate increases, and local edema, vesicle take place, severe patient generation dispersivity thrombosis, even cause tissue necrosis.The chilblain initial stage shows as pale, the local creeping chill of illing skin, and that presses fades, and occurs the aubergine lump that differs in size afterwards, and feeling of numbness is arranged earlier, titillation, swelling sense is arranged then, and with burn feeling, meet heat back sx, if scratching easily makes the epidermis breakage.The local skin back vasoconstriction of catching a cold follows bad badly, and the blood stasis of blood stagnates, and histanoxia can make capillary permeability increase, ooze out increase, and vesicle takes place in the swelling aggravation; Vesicle includes faint yellow or courageous and upright liquid, and sepage is flowed out in the back of breaking, and forms fester, and its substrate is dark red, and blush can have pain coated with yellow or purple blood crusts on every side.The chilblain wound surface is if secondary infection can cause vesicle ulcer, suppuration, incrustation, and weight person's course of disease often prolongs, and does not prolongedly control the person major diseases such as joint distortion, gangrene, septicemia, rheumatism even paralysis can take place.But chilblain spontaneous recovery when weather is warm leaves pigmentation spots after healing.If do not add protection winter in the coming year easily in former chilblain site of pathological change recurrence.That treating chilblain is to note is warming, participate in sports activites is beneficial to blood circulation more, notice that simultaneously nutrition is to reduce the possibility that chilblain takes place, but still have a large amount of patients tormented by the slight illness of chilblain at present, the morbidity situation of chilblain sternness has had a strong impact on daily life and healthy, has reduced people's quality of life.
The method of conventional therapy chilblain mainly contains: to not diabrosis chilblain, and external application kibe ointment behind the available Warm Wash; If chilblain diabrosis, but external application antimicrobial ointment.Folk prescription, the proved recipe that a lot of treatment chilblain are also arranged among the people, but curative effect is all not obvious, especially more not obvious at the effect of the plateau cold-damp area treatment chilblain at inventor place.
Folium Artemisiae Argyi is the dried leaves of feverfew Chinese mugwort Artemisia argyi L é vl.et Vant..Chinese mugwort is perennial herb, high 45-120cm; The obvious rib of stem tool, the top branch is by white short drafts hair.Single leaf, alternate, stem middle part leaf egg shape triangle or ellipse have handle, the pinniform drastic crack, the 2 pairs of sliver ellipses in both sides are to the ellipticity lanceolar, and centre normal again 3 is split, the equal tool sawtooth in sliver edge, above dirty-green, the glandule point that gathers, the white pubescence of rare quilt, below celadon, the white fine hair of close quilt; The full edge of stem top leaf leaf or 3 splits.Head inflorescence is arranged in again total shape, and involucre is avette, and is close by the thread fine hair of canescence; The little lace redness of tubular, outer instaminate flower, internal layer hermaphrodite flower.Achene Long Circle, no pappus.7-October of florescence.Folium Artemisiae Argyi bitter in the mouth, suffering, warm in nature.Return the liver,spleen,kidney warp; Fragrant, bitter dry suffering is loose, and can stop blooding by the dispelling cold and removing dampness warming the meridian, is gynecological's key medicine; Be usually used in treating menorrhagia, gestation hemorrhage, postpartum hemorrhage clothes pain can also be treated haematemesis, nose bleeding, has blood in stool, diseases such as hemorrhoid, chronic dysentery chronic diarrhea, the intestines and stomach wind heat; Folium Artemisiae Argyi prevents the effect of pestilence in addition; The parch to black hemostasis, the available deficiency and coldness menorrhagia of controlling, bleeding not during menses, vaginal bleeding during pregnancy is as Ass-hide Glue and Argyi Leaf Decoction; The treatment coldness and pain in the epigastrium, coldness and unbalance in meridians, infertile card, the available Aifu Nuangong Wan of waiting of cold womb.Folium Artemisiae Argyi is smash floss, makes moxa roll, Ai Zhu, outer moxibustion energy dispersing cold for relieving pain, warm QI and blood; The external removing dampness to relieve itching is fried in shallow oil the soup washout and can be treated skin pruritus, eczema scabies etc.But Shang Weiyou is with the relevant report of Chinese mugwort or Folium Artemisiae Argyi single Drug therapy chilblain.
Directly external application or smear treatment knife injury, wound, burn and scald and chilblain of Mel.Experiment confirm, Mel has stronger inhibitory action to gram positive bacterias such as streptococcus, staphylococcus, diphtheria corynebacteriums; When handling wound, Mel is applied to the affected part, can reduce and ooze out, ease the pain, promote wound healing, protect from infection.Report about Mel treatment chilblain had in the past: (1) A, scorching sick and the cold injury of secretions is arranged for having more than two degree, Mel is decocted, and with vaseline equivalent furnishing ointment, coat thinly on the aseptic gauze then, spread on the affected part.Before applying lid, earlier the injury is cleaned up; After applying lid, fixing with the dressing wrapping, after the general medication 2-3 times, pain and inflammation gradually disappear, and just can fully recover for 3-7 times; B, for chilblain: earlier with the warm water washing, the cleaning affected part is coated with the honey wrapping then; The next day, change dressings once, and a few days promptly heals.(2) get several wheat germ oils, 3 spoons of vaselines and 1 spoon of amount propolis and mix paste, spread on the affected part, massage is cleaned with antiseptic gauze gently, sooner or later respectively once.(3) with ripe Mel and Yellow Vaselin equivalent furnishing ointment, be applied to thinly on the sterile gauze, apply and to be placed on wound surface, each 2～3 layers, pain and inflammation gradually disappear after the general medication 3 times, apply and are expected for several times recovery from illness.(4) earlier wash the affected part with warm water, be coated with the honey wrapping then, every other day changes once, if ulceration not, can wrap up, only be coated with Mel and get final product.(5) Lac regis apis and commercially available vanishing cream are in harmonious proportion at 1: 1, every day, each once was coated on the chilblain affected part sooner or later, the red and swollen disappearance after general 5 days, and rotten position skin begins healing after 10 days, and the chilblain symptom all disappears after 15 days.
At present, also there is not the independent use of Chinese mugwort maybe will end and the relevant report of Mel compatibility application of treatment chilblain.
Summary of the invention
Technical scheme of the present invention has provided a kind of new purposes of Chinese mugwort.Another technical scheme of the present invention has provided a kind of prescription for the treatment of chilblain, and particularly, it is to be the medicament that feedstock production forms by natural drug; This medicaments preparation method also is provided simultaneously.Prescription of the present invention promptly is a pharmaceutical composition.
The invention provides the purposes of Chinese mugwort Artemisia argyi L é vl.et Vant. in the medicine of preparation treatment chilblain.
Wherein, described Chinese mugwort is herb, leaf, the fruit of feverfew Chinese mugwort Artemisia argyi L é vl.et Vant..Further preferred, described Chinese mugwort is the leaf of feverfew Chinese mugwort Artemisia argyi L é vl.et Vant..
The present invention also provides a kind of prescription for the treatment of chilblain, and it is that to contain with the Chinese mugwort be raw material, adds the medicament that pharmaceutically acceptable raw material, adjuvant or complementary one-tenth grade and is prepared from.
Further, this prescription is to contain the medicament that the following weight proportion raw material is prepared from:
20～200 parts of 5～500 parts, Mel end; Wherein, described Chinese mugwort can also be a Folium Artemisiae Argyi.
Further, the prescription of this treatment chilblain is the medicament that is prepared from by the following weight proportion raw material:
5～500 parts of Folium Artemisiae Argyis, 20～200 parts of Mel.
Further, it is the medicament that is prepared from by the following weight proportion raw material:
5 parts of Folium Artemisiae Argyis, 20 parts～30 parts of Mel.
Wherein, 5 parts of Folium Artemisiae Argyis, 20 parts of Mel (this materials of weight proportions is pulverized to mix well and be can be made into powder); Or
5 parts of Folium Artemisiae Argyis, 30 parts of Mel (this materials of weight proportions can be made into unguentum); Or
15 parts of Folium Artemisiae Argyis, 25 parts of Mel (this materials of weight proportions can be made into pill).
The character of the raw material Mel in the prescription, assay, inspection all meet the pharmacopeia requirement.
Particularly, prescription of the present invention is to be active component by the raw medicinal material of Chinese mugwort or extract, Mel, adds the medicament that acceptable accessories or complementary composition are prepared from.Further preferred, described Chinese mugwort is a Folium Artemisiae Argyi.
Wherein, described medicament is an external preparation.
Further, described external preparation is powder, pill, unguentum, Emulsion, membrane.
The present invention also provides the preparation method of this prescription, and it comprises the steps:
A, take by weighing Chinese mugwort, Mel by weight ratio;
B, get Chinese mugwort and be ground into extract powder after fine powder or water extract concentrate, mix with Mel; Add the preparation of acceptable accessories or complementary composition, promptly.
The present invention prescription in use needs to carry out warming measure, and prescription of the present invention is coated on the affected part, with warm oneself by a fire, electric heating, rub the affected part simultaneously, until the whole body heating, situation is adjusted treatment time according to being in a bad way, be generally 30 minutes, severe patient can extend to 60 minutes.
The present invention Chinese mugwort and Folium Artemisiae Argyi have the effect for the treatment of chilblain preferably, with Chinese mugwort or Folium Artemisiae Argyi with the Mel preparation medicament have the effect of significant treatment chilblain, and effective fast, have no side effect safely, for the clinical treatment chilblain provides a kind of new selection.
Obviously, according to foregoing of the present invention,,, can also make modification, replacement or the change of other various ways not breaking away under the above-mentioned basic fundamental thought of the present invention prerequisite according to the ordinary skill knowledge and the customary means of this area.
The specific embodiment of form is described in further detail foregoing of the present invention again by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
The specific embodiment
The preparation of embodiment 1 powder of the present invention
A, take by weighing dry Chinese mugwort 50 grams, Mel 200 grams;
B, pulverize Chinese mugwort, with Mel mix well powder.
Powder drug effect the best that this raw material weight proportioning is prepared from.
The preparation of embodiment 2 unguentum of the present invention
A, take by weighing dry Chinese mugwort 50 grams, Folium Artemisiae Argyi 50 grams, Mel 2000 grams;
B, pulverizing end, and mix well with Mel to get final product.
The preparation of embodiment 3 pills of the present invention
A, take by weighing dry Chinese mugwort 500 grams, Mel 200 grams;
B, pulverize Chinese mugwort, mix well, rub or machine is made ball, get final product with Mel.
The preparation of embodiment 4 pills of the present invention
A, take by weighing Folium Artemisiae Argyi 150g, Mel 250g;
B, pulverizing Folium Artemisiae Argyi become fine powder; With the Mel mixing, rub or machine is made ball, get final product.
Pill drug effect the best that this raw material weight proportioning is prepared from.
The preparation of embodiment 5 unguentum of the present invention
A, take by weighing Folium Artemisiae Argyi 50g, Mel 200g;
B, pulverizing Folium Artemisiae Argyi become fine powder; Get final product with the Mel mixing.
The preparation of embodiment 6 membrane of the present invention
A, take by weighing Folium Artemisiae Argyi 50g, Mel 2000g;
B, get Folium Artemisiae Argyi and decoct 3 times, each 45 minutes, merging filtrate was concentrated into relative density 1.1～1.3 backs and Mel mix homogeneously;
C, get an amount of filmogen PVA, heating in water bath adds the mixture among the step b, stirs, and adds glycerol, and mix homogeneously filters while hot, rubber cement;
D, after glass plate sterilization, coat liquid paraffin, again step c gained rubber cement be uniformly coated on glassly, place in the sterilization tank natural drying after 24 hours, homogeneous film, thin film is cut into small pieces by the 4cm*4cm specification, packing gets final product.
The preparation of embodiment 7 powders of the present invention
A, take by weighing Folium Artemisiae Argyi 500g, Mel 20g, the Chinese mugwort 50g;
B, pulverize Folium Artemisiae Argyi, Chinese mugwort and Mel mix well powder.
The preparation of embodiment 8 unguentum of the present invention
A, take by weighing Folium Artemisiae Argyi 50g, Borneolum Syntheticum 10g, Mel 300g;
B, pulverizing Folium Artemisiae Argyi, Borneolum Syntheticum grinds powder, mixes well with Mel to get final product.
The preparation of embodiment 9 pills of the present invention
A, take by weighing Folium Artemisiae Argyi 50g, Mel 250g;
B, pulverizing Folium Artemisiae Argyi become fine powder; With the Mel mixing, rub or machine is made ball, get final product.
The preparation of embodiment 10 unguentum of the present invention
A, take by weighing Folium Artemisiae Argyi 50g, Mel 300g;
B, pulverizing Folium Artemisiae Argyi become fine powder; Get final product with the Mel mixing.
Unguentum drug effect the best that this raw material weight proportioning is prepared from.
The preparation of embodiment 11 unguentum of the present invention
A, take by weighing Folium Artemisiae Argyi 5g, Mel 100g;
B, pulverizing Folium Artemisiae Argyi become fine powder; Get final product with the Mel mixing.
The preparation of embodiment 12 unguentum of the present invention
A, take by weighing Folium Artemisiae Argyi 5g, Mel 120g;
B, pulverizing Folium Artemisiae Argyi become fine powder; Get final product with the Mel mixing.
The preparation of embodiment 13 unguentum of the present invention
A, take by weighing Folium Artemisiae Argyi 5g, Mel 80g;
B, pulverizing Folium Artemisiae Argyi become fine powder; Get final product with the Mel mixing.
The following beneficial effect by evidence the present invention prescription.
The case statistics of test example 1 the present invention prescription
The present invention prescription (get) by embodiment 1-13 preparations 1989 to 2005 in the period of statistics to treat total case number be 3000 people, sufferer is all lived in cold-damp area, plateau (as Ganzi, Sichuan, Aba area).
Therapeutic modality: the present invention filled a prescription apply in the affected part, rubbed about 30 minutes on (or taking various feasible heating modes) limit of warming oneself by a fire, limit, till the whole body heating.Treat once every day, and continued treatment is until recovering.
Statistical data sees Table 1:
The case statistics of table 1 the present invention prescription
| Patient's state of an illness | Participate in the treatment number | The healing number | Cure rate | Average cure time |
| No diabrosis | 2902 | 2840 | 97.86％ | 5～7 days |
| Diabrosis is arranged | 98 | 91 | 92.86％ | 7～13 days |
Clinical experience proof embodiment 1,3,4,5,10,11,12,13 preparations and the prescription drug effect better.
The effect contrast test of test example 2 prescriptions of the present invention and Chinese mugwort, Folium Artemisiae Argyi, Mel
1, prescription of the present invention (being got by embodiment 1-13 preparations) was treated statistics in 1989 to 2005:
Patient 2902 people of the no diabrosis of treatment, red and swollen extinction time is generally at 5～7 days;
Treatment diabrosis patient 98 people, diabrosis healing time 7～13 days, symptom was all eliminated about 60 days.
Clinical experience proof embodiment 1,3,4,5,10,11,12,13 preparations and the prescription drug effect better.
Follow the tracks of for many years according to the inventor and to pay a return visit investigation: 2～3 years recovery times of muscle cell, meat skin (anti-skin) recovery time is 3～5 years, 7～9 years recovery times of fingernail, older needs of patients longer time.
2, use Mel separately:
Treat no diabrosis patient 10 people, treatment time is generally at 7～15 days, and lump is eliminated, but chapped skin is as bark from old tress, and liquid like the rice water is leached in chilblain be full of cracks place, and pruritus is felt bad, and occurs recurrence in 1 year;
Treat patient 10 people of seriously festering, 15～30 days treatment times, rotten position partly heals, and red and swollen part is eliminated, but recurs in the near future.
3, will end after (root of Chinese mugwort, bar, leaf, stem, flower, fruit) pulverizing, and mix deposited affected part with vaseline, treatment patient 2 people treated 5～8 days, the trend that chilblain does not have expansion and increases the weight of, but the not elimination of chilblain redness.
4, independent decocting Folium Artemisiae Argyi, decocting liquid is washed the affected part, treats 2 people, and 5～7 days treatment times, redness has elimination, but chapped skin.
Folium Artemisiae Argyi decocting liquid applies the affected part, treats 4 people, 5～7 days treatment times, treatment chilblain wound pain there is positive effect, but chapped skin, still not antiinflammatory of redness.
5, Mel and Huang, white vaseline (weight ratio 1:1) mixing apply the affected part, treat 2 people, about one week of treatment time, pain relieving, itching relieving effect are arranged, but the chilblain wound do not heal, in the near future recurrence.
6, Mel and vanishing cream (weight ratio 1:1) are mixed well deposited affected part, treat 2 people, about one week of treatment time, pain relieving, antipruritic, repercussive effect are arranged, but the chilblain wound does not heal recurrence in the near future.
7, Mel and iodine tincture are mixed well deposited affected part, treat 2 people, about one week of treatment time, effect antipruritic, antiinflammatory is arranged, but wound do not heal, in the near future recurrence.
Because the inventor is located in cold-damp area, plateau, the difficulty of treatment chilblain is greater than other area of China, above-mentioned test explanation uses Mel, Chinese mugwort, Folium Artemisiae Argyi, Mel and vaseline (1:1), Mel and vanishing cream (1:1) treatment chilblain that certain curative effect is all arranged separately, but the good effect of prescription of the present invention all useless (getting) by embodiment 1-13 preparations.
Chinese mugwort or Folium Artemisiae Argyi have the effect of treatment chilblain among the present invention, and prescription of the present invention has the effect of significant treatment chilblain, and the treatment chilblain is effective fast, and safety has no side effect, for the clinical treatment chilblain provides a kind of new selection.
Claims (8)
1, a kind of pharmaceutical composition for the treatment of chilblain is characterized in that: it is the medicament that is prepared from by following weight proportion raw material adding acceptable accessories or complementary composition:
20～200 parts of 5～500 parts, Mel end.
2, the pharmaceutical composition of treatment chilblain according to claim 1 is characterized in that: described Chinese mugwort is herb, leaf, the fruit of feverfew Chinese mugwort Artemisia argyi L é vl.et Vant..
3, the pharmaceutical composition of treatment chilblain according to claim 2 is characterized in that: described Chinese mugwort is a Folium Artemisiae Argyi.
4, the pharmaceutical composition of treatment chilblain according to claim 3 is characterized in that: it is the medicament that is prepared from by the following weight proportion raw material:
5～500 parts of Folium Artemisiae Argyis, 20～200 parts of Mel.
5, the pharmaceutical composition of treatment chilblain according to claim 4 is characterized in that: it is the medicament that is prepared from by the following weight proportion raw material:
5 parts of Folium Artemisiae Argyis, 20 parts～30 parts of Mel.
6, according to the pharmaceutical composition of each described treatment chilblain of claim 1～5, it is characterized in that: it is to be active component by the raw medicinal material of Chinese mugwort or extract, Mel, adds the medicament that acceptable accessories or complementary composition are prepared from.
7, the pharmaceutical composition of treatment chilblain according to claim 6 is characterized in that: described medicament is an external preparation.
8, a kind of method for preparing the pharmaceutical composition of each described treatment chilblain of claim 1～5, it comprises the steps:
A, take by weighing Chinese mugwort, Mel by weight ratio;
B, get Chinese mugwort and be ground into extract powder after fine powder or water extract concentrate, mix with Mel; Add the preparation of acceptable accessories or complementary composition, promptly.
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| CN104524078A (en) * | 2015-01-14 | 2015-04-22 | 黄琴 | Chilblain prevention medicine |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1249944A (en) * | 1999-09-28 | 2000-04-12 | 谢奇 | Effective chilblain treating liquid |
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| CN1249944A (en) * | 1999-09-28 | 2000-04-12 | 谢奇 | Effective chilblain treating liquid |
Non-Patent Citations (6)
| Title |
|---|
| 冻疮的治疗法. 陈贵善.科学快报. 2006 |
| 冻疮的治疗法. 陈贵善.科学快报. 2006 * |
| 桂苏酒治疗冻疮93例临床疗效观察. 黄兴川.黑龙江中医药，第6期. 1988 |
| 桂苏酒治疗冻疮93例临床疗效观察. 黄兴川.黑龙江中医药，第6期. 1988 * |
| 治冻疮. 付淑芳.老年日报. 2005 |
| 治冻疮. 付淑芳.老年日报. 2005 * |
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