JP7362140B2 - Chinese herbal medicine topical patch for treating gouty joint pain and its preparation method - Google Patents

Description

The present invention belongs to the field of Chinese herbal medicine, and specifically relates to a Chinese herbal medicine topical patch for treating gouty arthralgia and a method for preparing the same.

Gout is a metabolic disease closely associated with hyperuricemia and urate deposition. Hyperuricemia is a group of metabolic symptoms caused by purine metabolism disorder. Acute gouty arthritis (AGA) is caused by urate deposition due to increased blood uric acid in the body, causing local tissue damage and an inflammatory response, often involving the kidneys, and causing chronic It causes nephritis and kidney stone formation. Acute gouty arthritis has a higher incidence in men than in women, and it often occurs in the joints of the lower extremities.The joints and surrounding tissues are red, swollen, warm, and painful.It worsens at night, and the pain is unbearable. The disease is likely to recur, making it inconvenient for the patient to carry out activities, and is accompanied by symptoms such as headache, fever, and elevated white blood cell count. In recent years, as living standards have improved and lifestyles have changed, the intake of purines and proteins from high-fat, high-protein diets has increased, and the incidence of gout in China and the world has tended to rise and become younger. It is in. The 2017 China Gout Status Report White Paper states that there are over 8 million gout patients in China and that AGA is a common clinical symptom of gout disease.

The oldest record of gout disease in Chinese medicine is the recognition of joint lesions, and depending on the joint symptoms and etiology at the time of onset of gout, the clinical diagnosis in Chinese medicine is divided into categories such as "paralysis,""pain and numbness," and "hikkitsu." are categorized. Gout is thought to develop when external illness is added to congenital physical weakness, causing phlegm to accumulate in the meridians and joints. According to literature, the recognition of gout disease by ancient medical scientists was limited to joint lesions, ie, acute gouty arthritis. With the development of modern diagnostic technology, modern Chinese medical diagnosis has newly recognized and introduced hyperuricemia based on the traditional theory of Chinese medicine and modern medical theory, and
He proposed the theory that blood rheology abnormalities and circulatory disorders can be considered to be hemoturbidity.

Currently, clinically common drugs for preventing gout disease are mainly chemical drugs, and their respective purposes are to lower blood uric acid levels and to provide anti-inflammatory and analgesic effects. For example, colchicine, glucocorticoids, etc. have clear action, rapid efficacy, and can alleviate acute clinical symptoms, but they also cause gastrointestinal reactions, gastrointestinal bleeding, liver and kidney function damage, and substance metabolic disorders. There are different degrees of safety risks, and recurrence of symptoms is likely to occur after drug withdrawal.

To address the above technical problems, the present invention provides a Chinese herbal medicine topical patch for treating gouty arthralgia and a method for preparing the same. The topical patching of Chinese herbal medicine avoids the first-pass effect and adverse gastrointestinal reactions, acts directly on the affected area, has high safety, is easy to operate, and is safe for patients, without going through the method of oral administration through the gastrointestinal tract. Good adaptability.
In order to realize the above technical objectives, the present invention provides the following technical solutions.
A Chinese herbal medicine topical patch for treating gouty joint pain, including a backing material, drug, matrix, and anti-adhesive layer.
However, the drug is 30 to 35 parts by mass,
20-25 parts, Tushufu 30-35 parts, Cangzhuang 20-25 parts, Wei Lingxian 30-35 parts, Rhubarb 20-25 parts, Rhubarb 20-25 parts, Celestial Pollen 15-20 parts, Ice Piece (Borneol) Contains 5 to 7.5 parts.

Furthermore, the ice pieces can be replaced with any one of azone, eucalyptus oil, oleic acid, and menthol.

Furthermore, the backing material can be selected from non-woven fabrics or nylon fabrics.

Further, in weight percentage, the substrate is 85-92% and the drug is 8-15%.

The present invention further provides a method for preparing a Chinese herbal medicine topical patch for treating gouty arthralgia, which is characterized by comprising the following steps.
After pulverizing each raw material, it is mixed with the substrate for 30 to 42 minutes at a rotation speed of 180 to 200 r/min, defoamed, and applied to the backing material, dried at 50°C for 2 hours, and the surface is coated with an anti-adhesive layer. Then, a Chinese herbal medicine patch for topical use to treat gouty joint pain is obtained.

Furthermore, the raw material is ground into a fine powder of 100-120 mesh.

Furthermore, the method for preparing the substrate includes immersing the skeleton material in water, heating it until it dissolves after a swelling phenomenon appears, and then adding a humectant and mixing at 50 to 55°C for 1 hour to obtain the substrate. .

Furthermore, the framework material is a mixture of gelatin, carbomer, polyvinylpyrrolidone, sodium polyacrylate, and sodium carboxymethyl cellulose, and the humectant is a mixture of glycerin and polyethylene glycol 400, and the framework material and The mass ratio of the humectant is (11-12):(5-8).

Furthermore, the gelatin can be selected from agar and gum arabic powder.

Furthermore, the carbomer can be selected from any one of specifications 934, 940, and 941.

Furthermore, polyvinyl alcohol can be selected as the polyvinylpyrrolidone.

Furthermore, the sodium polyacrylate can be selected from polyacrylic acid or polyethylene glycol.

Furthermore, the carboxymethyl cellulose sodium can be selected from any one of carboxymethyl cellulose, methyl cellulose sodium, and cellulose derivatives.

Furthermore, the humectant can be selected from any one of azone, eucalyptus oil, oleic acid, and menthol.

Furthermore, the mass ratio of gelatin, carbomer, polyvinylpyrrolidone, sodium polyacrylate, sodium carboxymethylcellulose, glycerin, and polyethylene glycol 400 is (3-5):(6-8):(6-8):(10-12 ):(0.7-0.9):(7-9):(9-11).

Furthermore, the mass ratio of gelatin, carbomer, polyvinylpyrrolidone, sodium polyacrylate, sodium carboxymethylcellulose, glycerin, and polyethylene glycol 400 is 4:7:7:11:0.8:8:10.

The dosage after replacing the substrate component of the present invention also needs to be adjusted appropriately so that the viscosity is the same as the above-mentioned compounding ratio.

For the Chinese herbal medicine prescription adopted in the present invention, please refer to "Chinese Pharmacy Dictionary" (2020 edition).

Huangbai is the dried yellow bark of a Rutaceae plant. [Characteristic taste and pathogenesis] Bitterness, coldness. [Function and treatment] Cleansing, heating, drying, and dehumidifying, detoxifying and treating acne. It is used to treat steam fever diarrhea, jaundice and red urine, beriberi, bone steam fever, ulcers, and eczema and eczema.

Qin-gyo is the dried root of Gentianaceae plant Qin-gyou, coarse stem Qin-gyou or small Qin-gyou. [Characteristic taste and origin] Spicy, bitter, flat. Meridian: Stomach, liver, bile. [Function and treatment] Gynecosis, dampness and heat, numbness and pain, and weakness and fever. It is used for wind and damp numbness pain, paralysis and hemiplegia, muscle spasm, bone acid pain, damp heat jaundice, bone steam fever, and childhood phlegm fever.

Tugenkaze is the dried whole plant of a plant in the family Amenaceae. [Characteristic taste and pathogenesis] Bitterness, spicyness, and flatness. [Function and treatment] Cool and cool blood, exfoliation of live blood, gout and gout. It is used for hemorrhagic rashes, wind damp numbness pain, and crush injuries.

Soshu is the dried rhizome of Soshu or Hokusoshu, a plant belonging to the Ranunculaceae family. [Taste and meridian] Spicy, bitter, warm. Meridian: spleen, stomach, liver. [Function and main treatment] Dry, wet and healthy spleen, wind and cold, clear eyes. humid embolism,
It is used to treat defecation, dropsy, beriberi, numbness and pain of wind, cold and cold, night blindness, and stupor of the eyes.

Weilingxian is the dried roots and rhizomes of the Ranunculaceae plant Weilingxian, the cotton tangle lotus, or the Tohoku railway lotus. [Sexual taste and origin] Spicy, spicy, warm. Return: Bladder. [Function and main treatment] Leaves and humidity, meridians. It is used for wind and damp numbness, limb paralysis, meridian spasm, and disadvantages in bending and stretching.

Rhubarb is the dried rhizome of palmate rhubarb, Tanggutoku rhubarb, or medicinal rhubarb, a plant belonging to the Polygonaceae family. [Characteristic taste and pathogenesis] Bitterness, coldness. Meridians: spleen, stomach, large intestine, liver, heart capsule. [Function and management] Cathartic attack, clear heat purification, cool blood detoxification,
Humid and yellow. It is used for constipation caused by accumulation of heat, blood fever vomit, erythropharyma of the eye, carbuncle acne, crush injury, jaundice and red urine; external treatment for burns. Dai-Aoba is the dried leaf of the Brassica plant. [Characteristic taste and pathogenesis] Bitterness, coldness. Return to sutra: heart, stomach. [Function and treatment] Clear heat detoxification, cool blood exfoliation. It is used to treat high fever, fainting, macular rash, mumps, throat numbness, erysipelas, and carbuncles.

Heavenly pollen is
Or the dry roots of Fuangen or Lou. [Taste and origin] Sweet, slightly bitter, slightly cold. Return: lungs, stomach. [Function and treatment] Clearing heat, quenching thirst, extinguishing swelling and draining pus. It is used for fever and thirst, lung fever and dry cough, internal fever, and ulcer poisoning. Medicinal mechanism of the invention:

Yuan. Zhu Zhenheng's ``Sixty-Three Gout Methods'' says: ``All over the body joint pain, day and night play, like a tiger biting, famous white tiger history festival'' ``large amount of phlegm, wind fever, wind dampness, blood deficiency.'' , the onset of gout is due to wind damp heat,
The taste of Wei Ling Immortal is spicy, spicy, and warm, and the taste of Tushu is bitter, spicy, and flat, and it can eliminate rheumatism and improve the meridian passage, and both Huangbai is bitterness and coldness, Qingyo is spicy, bitterness, and flatness; Rhubarb is bitterness and coldness;
It is a vassal medicine with the action of lord medicine, and when combined with lord medicine, it has the effect of eliminating wind, clearing fever, and pain relief. It is a medicine that helps with dampness and coldness, and celestial pollen is sweet, slightly bitter, and has a slight coldness, and it is used together with ice chips to treat swelling, and the various medicines reach the pain through the skin and improve the overall composition. Viewed from above, it has the effect of eliminating gout and eliminating numbness and pain.

Compared to the prior art, the beneficial effects of the present invention are:
When using the patch of the present invention, it is applied directly to the affected area, and its action is soothing and lasting, and the effect of reducing swelling and pain is remarkable, and it can effectively prevent or alleviate joint pain caused by gout. Can improve nodules, easy to use, good patient adaptability, no irritation, suitable for multiple doses. and avoid the unpalatable defects of oral drugs. At the same time, the consistency of the matrix is appropriate, so it feels refreshing when applied to the skin surface, and can relieve local symptoms of redness, swelling, heat, and pain, and the added transdermal enhancer ingredients are The penetration of the product can be accelerated and the purpose of immediate effect can be achieved. In the preparation process of the matrix, the ratio of each component, heating temperature, stirring speed, mixing time, and degree of defoaming can all affect the consistency and drug release performance of the matrix, and each influencing factor can be combined with each other. , it is necessary to finally produce a product with the corresponding effect.

Various exemplary embodiments of the invention will be described in detail, but this detailed description is not intended to limit the invention, but rather to provide a more detailed description and understanding of particular aspects, features, and embodiments of the invention. Should.

The terminology described in the present invention is merely for describing particular embodiments and is not intended to limit the invention. It should also be understood that for the numerical ranges of the present invention, each intermediate value between the upper and lower limits of the range is also specifically disclosed. Any stated value or intermediate value within a stated range and any smaller range between any other stated value or intermediate value within said range are included in the invention. The upper and lower limits of these smaller ranges may be independently included or excluded within the range.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. Although only preferred methods and materials are described in the invention, any methods and materials similar or equivalent to those described herein may be used in the practice or measurement of the invention. All documents mentioned herein are incorporated by reference to disclose and describe the methods and/or materials to which they relate. In the event of a conflict with incorporated documents, the present specification will control.

It will be obvious to those skilled in the art that various improvements and changes can be made to the mode of carrying out the invention described herein without departing from the scope or spirit of the invention. Other embodiments will be apparent to those skilled in the art given the present specification. The specification and examples are exemplary.

As used herein, the terms "comprising," "having," "containing," and the like are open terms, meaning including but not limited to.

The Chinese herbal medicine topical patch for treating gouty arthralgia prepared according to the present invention has a total weight of drug and substrate of 18.0±0.5 g per 10×8 cm ² of backing material.

The sample prepared according to the present invention complies with the section ``0122 Patch agent'' of Part 4 of the "Chinese Pharmacopoeia" (2020 edition), and was measured for heat resistance, formability, content uniformity, etc. , all meet standard requirements, and irritation and allergy experiments show that it is not irritating or allergic to the skin.

[Example 1]
(1) Selection of raw materials:
33 parts of Huangbai, 23 parts of Qin Gyeong, 32 parts of Tushuanfu, 22 parts of Cangzhuang, 32 parts of Wei Lingxian, 22 parts of Rhubarb, 23 parts of Great Green Leaves, 18 parts of Heavenly Pollen, and 6 parts of Ice Pieces.
(2) Each of the weighed raw materials was ground and passed through a 110 mesh sieve to obtain a fine drug powder.
(3) Add the substrate so that the weight percentage is gelatin: carbomer: polyvinylpyrrolidone: sodium polyacrylate: sodium carboxymethyl cellulose: glycerin: polyethylene glycol 400 = 4:7:7:11:0.8:8:10. Prepared.
(4) Substrate manufacturing method: Gelatin, carbomer, polyvinylpyrrolidone, sodium polyacrylate, and sodium carboxymethylcellulose are immersed in water, swelled, and heated until dissolved, then added with glycerin and polyethylene glycol 400, and heated at 53°C for 1 hour. The mixture was mixed to obtain a substrate.
(5) Fine drug powder and substrate were mixed at a rotational speed of 190 r/min for 36 min, defoamed, applied to a nonwoven fabric, cut, dried at 50°C for 2 hours, and covered the surface with an anti-adhesive layer. We obtained a topical Chinese herbal medicine patch for treating gouty joint pain.
The substrate accounted for 88% and the drug accounted for 12%.

[Example 2]
(1) Selection of raw materials:
35 parts of Huangbao, 25 parts of Qin Gyeong, 30 parts of Tuanjifu, 20 parts of Cangzhuang, 35 parts of Wei Lingxian, 25 parts of Rhubarb, 20 parts of Great Green Leaves, 15 parts of Heavenly Pollen, and 5 parts of Ice Pieces.
(2) The weighed raw materials were each ground, passed through a 120-mesh sieve, and mixed to obtain a fine drug powder.
(3) Add the substrate so that the weight percentage is gelatin: carbomer: polyvinylpyrrolidone: sodium polyacrylate: sodium carboxymethyl cellulose: glycerin: polyethylene glycol 400 = 4:6:7:10:0.8:7:11. Prepared.
(4) Substrate manufacturing method: Gelatin, carbomer, polyvinylpyrrolidone, sodium polyacrylate, and sodium carboxymethylcellulose are immersed in water, swollen, and heated until dissolved, then added with glycerin and polyethylene glycol 400, and heated at 50°C for 1 hour. The mixture was mixed to obtain a substrate.
(5) The fine powder of the drug and the substrate were mixed at a rotation speed of 180 r/min for 42 min, defoamed, applied to a nonwoven fabric, cut, dried at 50°C for 2 hours, and the surface was coated with an anti-adhesive layer. We obtained a topical Chinese herbal medicine patch for treating gouty joint pain.
The substrate accounted for 85% and the drug 15%.

[Example 3]
(1) Selection of raw materials:
30 parts of huangbai, 20 parts of chinensis, 35 parts of Tuanjifu, 25 parts of Cangzhuang, 30 parts of Wei Lingxian, 20 parts of Rhubarb, 25 parts of Big Green Leaves, 20 parts of Celestial Pollen, and 7.5 parts of Ice Pieces.
(2) The weighed raw materials were each ground, passed through a 100-mesh sieve, and mixed to obtain a fine drug powder.
(3) Add the substrate so that the weight percentage is gelatin: carbomer: polyvinylpyrrolidone: sodium polyacrylate: sodium carboxymethyl cellulose: glycerin: polyethylene glycol 400 = 3:7:7:11:0.8:9:10. Prepared.
(4) Substrate manufacturing method: Soak gelatin, carbomer, polyvinylpyrrolidone, sodium polyacrylate, and sodium carboxymethylcellulose in water, swell, and heat until dissolved, then add glycerin and polyethylene glycol 400, and heat at 55°C for 1 hour. The mixture was mixed to obtain a substrate.
(5) Mix the fine drug powder and the substrate at a rotational speed of 190 r/min for 36 min, defoaming, apply to nylon cloth, cut, dry at 50°C for 2 hours, and cover the surface with an anti-adhesive layer. We obtained a Chinese herbal medicine patch for topical use to treat gouty joint pain.
The substrate accounted for 92% and the drug accounted for 8%.

[Example 4]
(1) Selection of raw materials:
33 parts of Huangbao, 21 parts of Qin Zhuang, 30 parts of Tuanjianfu, 24 parts of Cangzhuang, 34 parts of Wei Lingxian, 21 parts of Rhubarb, 22 parts of Big Green Leaves, 19 parts of Celestial Pollen, and 5.5 parts of Eucalyptus oil.
(2) The weighed raw materials were each ground, passed through a 110-mesh sieve, and mixed to obtain a fine drug powder.
(3) A substrate was prepared so that the weight percentage of agar: carbomer: polyvinylpyrrolidone: sodium polyacrylate: sodium carboxymethyl cellulose: propylene glycol was 5:6:7:10:0.8:17.
(4) Substrate manufacturing method: gelatin, carbomer, polyvinylpyrrolidone, sodium polyacrylate, and sodium carboxymethylcellulose are immersed in water, allowed to swell, heated until dissolved, further added with propylene glycol, and mixed at 53°C for 1 hour. Obtained the substrate.
(5) Fine drug powder and substrate were mixed at a rotational speed of 190 r/min for 36 min, defoamed, applied to a nonwoven fabric, cut, dried at 50°C for 2 hours, and covered the surface with an anti-adhesive layer. We obtained a topical Chinese herbal medicine patch for treating gouty joint pain.
The substrate accounted for 90% and the drug 10%.

[Comparative example 1]
The procedure was the same as in Example 1 except that the raw materials were crushed and passed through an 80 mesh sieve.

[Comparative example 2]
The procedure was the same as in Example 1 except that the fine powder of the drug and the substrate were mixed at a rotational speed of 100 r/min.

[Comparative example 3]
The procedure was the same as in Example 1 except that the mixing time of the fine drug powder and the substrate was 20 min.

[Comparative example 4]
Same as Example 1 except that the substrate accounts for 95% and the drug accounts for 5%.

[Comparative example 6]
Same as Example 1 except that the substrate accounts for 80% and the drug accounts for 20%.
The viscosity of the prepared Chinese herbal medicine patch for external use is too high, and the application effect and sensation are not good.

[Comparative example 7]
It is the same as Example 1 except that the heating temperature in step (4) is 72°C.
Because the heating time is too long, the viscosity of the matrix material changes, which weakens the effectiveness of the prepared Chinese herbal medicine topical patch.

1. Observation of clinical treatment effects:
Gouty arthralgia of the patch of the present invention (Examples 1 to 4), the control group patch (Comparative Examples 1 to 7), and the Chinese herbal medicine patch for gouty arthralgia sold at pharmacies (control group) The therapeutic effect was observed and verified.
1100 patients with gouty arthritis were selected and randomly divided into 11 groups, each group having 100 patients. There were no statistical differences in age, gender, disease course, or degree of joint pain in each group (p>0.05).
Method of treatment:
The patch is applied directly to the joint once a day, and one course lasts 12 days.
Judgment standard:
1. Healing: joint pain disappears or almost disappears, joint activity returns to normal, and there is no joint swelling phenomenon.
2. Effective: joint pain sensation improves, joint activity is slightly restricted, accompanied by mild joint swelling phenomenon.
3. Ineffective: joint pain sensation is not obviously improved, even becomes heavy, joint activity is restricted, activity is difficult, and severe joint swelling phenomenon occurs.

Test results:
After 12 days of treatment, the statistical results of clinical treatment effects for each test group are shown in Table 1.
No abnormalities were found in routine blood, urine, and stool tests, liver and kidney functions, and electrocardiograms of the above patients before and after treatment. At the subsequent re-examination, joint pain and nodules due to gout were not observed in the patients with gout treated with the patch prepared according to the present invention.

As can be seen from Table 1, after 12 days of treatment, the patients using the patch of the present invention were basically cured, but Comparative Examples 1 to 7, which are patches not prepared by the preparation method of the present invention. The effectiveness rate of is basically less than 90%, and the patch for treating gouty arthralgia of the present invention becomes more effective after being processed according to the specific preparation method of the present invention. Even after 12 days of treatment with a patch sold at a pharmacy, the effect was clearly not good.

2.Currently, clinically, patients with gouty arthritis are generally treated with ibuprofen. In order to verify the effects of the patch prepared according to the present invention, the following verification was performed.
Seventy patients with acute gouty arthritis (all male) were selected and randomly divided into a control group (administering ibuprofen only) and a treatment group (administering ibuprofen and using the patch prepared in Example 1 at the same time). There were 35 patients in each group. The treatment time was 12 days, and the patient's laboratory indicators [erythrocyte sedimentation rate (ESR), blood uric acid (UA), -reactive protein (CRP)], Chinese medicine symptom evaluation, joint swelling and activity level before and after treatment were evaluated. The patient's pain response and poor response status were observed.

The results show that:
1) After treatment, the ESR, UA, and CRP levels of patients in the two groups were all lower than before treatment (p<0.05), and the differences between the groups were not statistically significant.
2) In comparing the evaluation of Chinese medicine symptoms, the treatment group was lower than the control group (p<0.05).
3) There was no statistical significance in the differences between groups in joint swelling and activity evaluation.
4) The time for complete relief of joint pain was shorter in the treatment group than in the control group (p<0.05).
5) No abnormalities were found in routine blood, urine, and stool tests, liver and kidney functions, and electrocardiograms before and after treatment of patients in the two groups.
From the above clinical treatment results, when treating acute gouty arthritis in combination with ibuprofen, the clinical symptoms of patients can be significantly improved and the disease process can be shortened, and the prepared Chinese herbal medicine patch of the present invention can be used for topical use. has shown to have a good therapeutic effect in treating gouty arthralgia, and if you do not want to take the drug orally, you can choose the patch of the present invention, which also has a therapeutic effect. Alternatively, when used in combination with oral medications, they can shorten the disease process, reduce suffering, and expand patient options.

Case:
Ms. Wang, 45 years old, had suffered from gouty arthralgia for 3 years, which made her movements inconvenient and extremely painful. After using the patch of the present invention for 6 days, the swelling disappeared and the pain was relieved, and after 6 days of treatment, the patient returned to normal and was clinically cured.

Mr. Lee, 38 years old, had been suffering from acute gout for a year, and even after taking Western drugs, there was no significant treatment effect. The patch of the present invention was applied once a day, and the pain was alleviated after 3 days, and after 9 days of continuous use, the symptoms were clearly improved and the pain almost disappeared, and continued for 1 month. I used it and my symptoms disappeared.

Mr. Qian, 58 years old, had suffered from osteoarthritis for 5 years and had joint pain in his limbs and was unable to walk. After using the patch of the present invention for 12 days, the patient had no pain and became able to move freely after one course of treatment.

The above are merely preferred embodiments of the invention and are not intended to limit the invention. All modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention are included within the protection scope of the present invention.

Claims (5)

A method for preparing a Chinese herbal medicine topical patch for treating gouty joint pain, the method comprising:
The Chinese herbal medicine topical patch includes a backing material, a drug, a substrate, and an anti-adhesion layer,
The drug contains, as raw materials, 30 to 35 parts of Huangbai, 20 to 25 parts of Qin Yang, 30 to 35 parts of Tuanjiang, 20 to 25 parts of Cangzhu, 30 to 35 parts of Wei Lingxian, and 20 to 25 parts of Rhubarb. Contains 20 to 25 parts of large green leaves, 15 to 20 parts of heavenly pollen, and 5 to 7.5 parts of ice chips.
In mass percentage, the substrate is 85-92% and the drug is 8-15%;
The method for preparing the Chinese herbal medicine topical patch for treating gouty arthralgia is as follows :
After pulverizing each raw material, it is mixed with the substrate for 30 to 42 minutes at a rotation speed of 180 to 200 r/min, defoamed, and applied to a backing material, dried at 50°C for 2 hours, and the surface is coated with an anti-adhesive layer. and obtaining a Chinese herbal medicine topical patch for treating gouty joint pain;
The method for preparing the substrate is to obtain the substrate by immersing the skeleton material in water, heating it until it dissolves after a swelling phenomenon appears, adding a humectant, and mixing at 50 to 55°C for 1 hour. A method for preparing a Chinese herbal medicine topical patch for treating gouty arthralgia, characterized by the following. The method for preparing a Chinese herbal medicine topical patch for treating gouty arthralgia according to claim 1, wherein the raw material is pulverized into a fine powder of 100 to 120 mesh. The framework material is a mixture of gelatin, carbomer, polyvinylpyrrolidone, sodium polyacrylate, and sodium carboxymethylcellulose, and the moisturizer is a mixture of glycerin and polyethylene glycol 400, and the framework material and the moisturizer The method for preparing a Chinese herbal medicine topical patch for treating gouty arthralgia according to claim 1, wherein the mass ratio of the agents is (11-12):(5-8). The mass ratio of gelatin, carbomer, polyvinylpyrrolidone, sodium polyacrylate, sodium carboxymethylcellulose, glycerin, and polyethylene glycol 400 is (3-5):(6-8):(6-8):(10-12): (0.7-0.9):(7-9):(9-11) The method for preparing a Chinese herbal medicine topical patch for treating gouty arthralgia according to claim 3. Claim characterized in that the mass ratio of gelatin, carbomer, polyvinylpyrrolidone, sodium polyacrylate, sodium carboxymethylcellulose, glycerin, and polyethylene glycol 400 is 4:7:7:11:0.8:8:10. 3. The method for preparing a Chinese herbal medicine topical patch for treating gouty arthralgia according to 3.