CN104857366A - Preoperative intervention medicine composition for neurosurgery and application thereof - Google Patents

Abstract

The invention discloses a preoperative intervention medicine composition for neurosurgery. The medicine composition is composed of raw medical materials, including, medicinal cyathula root, fructus cinnamomi, changnienia amoena, Chinese honeylocust spine, cohosh, jasminum grandiflorum, entadae stem, loofah sponge, ternate buttercup root, Chinese starjasmine stem, asarum caulescens, sunflower flowers, loranthus parasiticus, stir-fried green beans, betula luminifera bark, wild buckwheat stem leaves, coix seeds, leonurus, red flowers and kudzuvine roots. The compatibility of medicines of the medicine composition is in accordance with the principle of assistant and guide in TCM (Traditional Chinese Medicine), the preparation is simple and convenient, the medicinal herbs resource is wide, the cost is low, the curative effect is definite, the toxic and side effect is small, and the preoperative intervention medicine composition for neurosurgery is suitable for be generalized and applied in a wide scope.

Description

A kind of preoperative intervention pharmaceutical composition of neurosurgery and application thereof

Technical field

The invention belongs to medical art, relate to a kind of Chinese medicine composition, be specifically related to the preoperative intervention pharmaceutical composition of a kind of neurosurgery and application thereof.

Background technology

Neurosurgery, is also often called department of cerebral surgery, is an offspring of surgery, treats neural disease with the method for surgery.Neurosurgery is acknowledged as the field that medically status is the highest, its reason be to complete such operation to the extremely complicated Knowledge Base required for doctor and to obtain carry out such operation permission required for the strict selection of process.Neurosurgery, especially relates to the patient of operation of opening cranium, and due to the impact of anesthesia, wound, high cranium pressure, endotracheal tube stimulation, extraneous factor, its post-operative complication is much higher compared with other surgical operations.As the incidence rate of shiver with cold after idiopathic general anesthesia (postanesthesia shivering, PS), previously bibliographical information, common surgical procedures is 5% ~ 38%, and operation of opening cranium is then 13% ~ 65%.Shiver with cold after so-called idiopathic general anesthesia, also claim " penthiobarbital sample is tetanic ", belong to complication of anesthesia.Shiver with cold under physiological status be body to hypothermic compensation response, the heat production by skeletal muscle quick Rythmic contractions characteristic.Mechanism after Craniocerebral Surgery is then relevant with the dysfunction of postoperative brain thermotaxic centre, and simultaneously with the sympathetic nerve function retardance under narcotism, heat again profile adjustment is not normal.

At present, the treatment for PS is symptomatic treatment targetedly, adopts morphine receptor analeptic Pethidine more, or maincenter respiratory stimulant medicine doxapram.But namely shiver with cold can occur together while occurring, organism metabolism rate significantly raises the cardiopulmonary load caused increases; Even myocardial ischemia; Also can damage platelet function, coagulation cascade response inhabitation, blood loss significantly increases, and transfusion volume increases simultaneously.Therefore how to carry out effective prevention in the preoperative, reducing the incidence rate of PS, and can not cause other post-operative complication, is the new problem of research of neurosurgery operation of opening cranium.

Summary of the invention

The present invention is directed to weak point of the prior art, provide a kind of curative effect certainly and the little preoperative intervention pharmaceutical composition of neurosurgery of side effect and application thereof.

Above-mentioned purpose of the present invention is realized by following technical proposals:

The preoperative intervention pharmaceutical composition of a kind of neurosurgery, the crude drug of described pharmaceutical composition is made up of nine layers of wind, Fructus cinnamomi immaturus, Herba Changnieniae amoenae, Spina Gleditsiae, Rhizoma Cimicifugae, Flos jasmini, Caulis Entadae, Retinervus Luffae Fructus, Radix Ranunculi Ternati, Caulis Trachelospermi, large Herba Swertiae heteranthae, Flos Helianthi, Herba Taxilli, stir-fried kidney beans, Cortex Betulae Luminiferae, Rhizoma Fagopyri Dibotryis stem and leaf, Semen Coicis, Herba Leonuri, Flos Carthami, Radix Puerariae.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: nine layers of wind 12-20 part, Fructus cinnamomi immaturus 10-16 part, Semen Coicis 3-8 part, Herba Changnieniae amoenae 5-12 part, Rhizoma Cimicifugae 12-17 part, Spina Gleditsiae 7-12 part, Flos Carthami 4-9 part, Retinervus Luffae Fructus 15-20 part, Radix Ranunculi Ternati 10-15 part, Caulis Trachelospermi 8-12 part, large Herba Swertiae heteranthae 2-5 part, Caulis Entadae 3-7 part, Flos Helianthi 11-14 part, Herba Taxilli 9-15 part, Flos jasmini 3-6 part, stir-fried kidney beans 8-13 part, Herba Leonuri 3-5 part, Rhizoma Fagopyri Dibotryis stem and leaf 1-3 part, Cortex Betulae Luminiferae 1-3 part, Radix Puerariae 5-10 part.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: nine layers of wind 12 parts, Fructus cinnamomi immaturus 16 parts, Semen Coicis 3 parts, Herba Changnieniae amoenae 12 parts, Rhizoma Cimicifugae 12 parts, Spina Gleditsiae 10 parts, 9 parts, Flos Carthami, Retinervus Luffae Fructus 15 parts, Radix Ranunculi Ternati 15 parts, Caulis Trachelospermi 8 parts, large Herba Swertiae heteranthae 5 parts, Caulis Entadae 3 parts, Flos Helianthi 14 parts, Herba Taxilli 9 parts, Flos jasmini 6 parts, stir-fried kidney beans 8 parts, Herba Leonuri 5 parts, Rhizoma Fagopyri Dibotryis stem and leaf 1 part, Cortex Betulae Luminiferae 1 part, Radix Puerariae 10 parts.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: nine layers of wind 20 parts, Fructus cinnamomi immaturus 10 parts, Semen Coicis 8 parts, Herba Changnieniae amoenae 5 parts, Rhizoma Cimicifugae 17 parts, Spina Gleditsiae 12 parts, 4 parts, Flos Carthami, Retinervus Luffae Fructus 20 parts, Radix Ranunculi Ternati 10 parts, Caulis Trachelospermi 12 parts, large Herba Swertiae heteranthae 2 parts, Caulis Entadae 7 parts, Flos Helianthi 11 parts, Herba Taxilli 15 parts, Flos jasmini 3 parts, stir-fried kidney beans 13 parts, Herba Leonuri 3 parts, Rhizoma Fagopyri Dibotryis stem and leaf 3 parts, Cortex Betulae Luminiferae 3 parts, Radix Puerariae 5 parts.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: nine layers of wind 13 parts, Fructus cinnamomi immaturus 11 parts, Semen Coicis 4 parts, Herba Changnieniae amoenae 6 parts, Rhizoma Cimicifugae 13 parts, Spina Gleditsiae 7 parts, 5 parts, Flos Carthami, Retinervus Luffae Fructus 18 parts, Radix Ranunculi Ternati 11 parts, Caulis Trachelospermi 9 parts, large Herba Swertiae heteranthae 4 parts, Caulis Entadae 6 parts, Flos Helianthi 12 parts, Herba Taxilli 13 parts, Flos jasmini 4 parts, stir-fried kidney beans 9 parts, Herba Leonuri 4 parts, Rhizoma Fagopyri Dibotryis stem and leaf 2 parts, Cortex Betulae Luminiferae 2 parts, Radix Puerariae 6 parts.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: nine layers of wind 17 parts, Fructus cinnamomi immaturus 15 parts, Semen Coicis 7 parts, Herba Changnieniae amoenae 11 parts, Rhizoma Cimicifugae 16 parts, Spina Gleditsiae 8 parts, 8 parts, Flos Carthami, Retinervus Luffae Fructus 16 parts, Radix Ranunculi Ternati 14 parts, Caulis Trachelospermi 11 parts, large Herba Swertiae heteranthae 3 parts, Caulis Entadae 5 parts, Flos Helianthi 13 parts, Herba Taxilli 14 parts, Flos jasmini 5 parts, stir-fried kidney beans 12 parts, Herba Leonuri 3 parts, Rhizoma Fagopyri Dibotryis stem and leaf 1 part, Cortex Betulae Luminiferae 1 part, Radix Puerariae 10 parts.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: nine layers of wind 15 parts, Fructus cinnamomi immaturus 12 parts, Semen Coicis 5 parts, Herba Changnieniae amoenae 9 parts, Rhizoma Cimicifugae 15 parts, Spina Gleditsiae 9 parts, 7 parts, Flos Carthami, Retinervus Luffae Fructus 19 parts, Radix Ranunculi Ternati 13 parts, Caulis Trachelospermi 10 parts, large Herba Swertiae heteranthae 4 parts, Caulis Entadae 4 parts, Flos Helianthi 11 parts, Herba Taxilli 11 parts, Flos jasmini 5 parts, stir-fried kidney beans 10 parts, Herba Leonuri 5 parts, Rhizoma Fagopyri Dibotryis stem and leaf 3 parts, Cortex Betulae Luminiferae 3 parts, Radix Puerariae 8 parts.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: nine layers of wind 19 parts, Fructus cinnamomi immaturus 14 parts, Semen Coicis 6 parts, Herba Changnieniae amoenae 7 parts, Rhizoma Cimicifugae 14 parts, Spina Gleditsiae 9 parts, 6 parts, Flos Carthami, Retinervus Luffae Fructus 17 parts, Radix Ranunculi Ternati 13 parts, Caulis Trachelospermi 10 parts, large Herba Swertiae heteranthae 4 parts, Caulis Entadae 4 parts, Flos Helianthi 11 parts, Herba Taxilli 11 parts, Flos jasmini 5 parts, stir-fried kidney beans 10 parts, Herba Leonuri 5 parts, Rhizoma Fagopyri Dibotryis stem and leaf 3 parts, Cortex Betulae Luminiferae 3 parts, Radix Puerariae 8 parts.

Further, described Chinese medicine composition is prepared according to following method:

(1) get each medical material of components by weight percent in arbitrary described pharmaceutical composition, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decocts 1-2 hour: second time adds the water of 8-12 times amount, decocts 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10-1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) pulverized by dry extract obtained for step (2), add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule; Or the dry extract that step (2) is obtained dry, pulverize, and makes powder; Or dry extract obtained for step (2) is pulverized, adds appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule; Or dry extract obtained for step (2) is pulverized, adds suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet; Or to above-mentioned steps (2) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

The invention still further relates to the application of a kind of described pharmaceutical composition in the preoperative intervention medicine of neurosurgery.

The preoperative intervention pharmaceutical composition of neurosurgery provided by the present invention, it for raw material, gives full play to the property of medicine of each component with common Chinese herbal medicine:

Nine layers of wind are the dry rattan of leguminous plant spatholobus suberectus Spatholobus suberectus Dunn.Nature and flavor are bitter, sweet, temperature.Return liver, kidney channel.Merit can be enriched blood, and invigorates blood circulation, dredging collateral.

Fructus cinnamomi immaturus, the tender fruit of the children for canella Cortex Cinnamomi.Gas fragrance, taste is micro-sweet.Nature and flavor Wen Xingan, returns stomach warp.Merit can warming spleen and stomach for dispelling cold.

Herba Changnieniae amoenae, is the orchid family Herba Changnieniae amoenae Changuienia amoena Chien, is used as medicine with herb, root.Merit can heat clearing away, removing heat from blood, removing toxic substances.

Spina Gleditsiae is the dry Spina jujubae of leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..Nature and flavor are pungent, temperature.Return liver, stomach warp.Merit can be subsided a swelling poison holding, evacuation of pus, parasite killing.

Rhizoma Cimicifugae is the dry rhizome of cohosh C.heracleifolia Cimicifuga heracleifolia Kom., Cimicifuga Dahurica Cimicifugadahurica (Turcz.) Maxim. or Rhizoma Cimicifugae Cimicifuga foetida L..Nature and flavor are pungent, micro-sweet, are slightly cold.Return lung, spleen, stomach, large intestine channel.Merit can deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.

Flos jasmini is Oleaceae plants Flos jasmini Jasminu, the dry flower of grandiflorum L..Property mildly bitter flavor; Property is put down.Return Liver Channel.Merit can soothing liver-QI for relieving depression, promoting the circulation of QI to relieve pain.

Caulis Entadae is stem, the leaf of moraceae plants Radix Pachyrhizi Erosi banyan Ficus tikouaBur..Nature and flavor bitter in the mouth; Cold in nature.Merit can clearing away heat-damp and promoting diuresis; Promoting blood circulation to remove obstruction in the collateral; Removing toxic substances and promoting subsidence of swelling.

Retinervus Luffae Fructus is the vascular bundle of the dry mature fruit of cucurbitaceous plant Fructus Luffae Luffa cylindrica (L.) Roem..Sweet, flat.Return lung, stomach, Liver Channel.Merit can dredging collateral, invigorates blood circulation, dispels the wind.

Radix Ranunculi Ternati is the dried root of ranunculaceae plant Seynuns Kugelann Ranunculus ternatus Thunb..Nature and flavor sweet, acrid, warm.Return liver, lung meridian.Merit can eliminating stagnation, detumescence.

Caulis Trachelospermi is the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide Trachelospermum jasminoides (Lindl.) Lem..Hardship, is slightly cold.GUIXIN, liver, kidney channel.Merit can dispelling wind and removing obstruction in the collateral, and removing heat from blood is subsided a swelling.

Large Herba Swertiae heteranthae, for aristolochiaceae plant becomes mildewed the herb of Herba Asari or root, rhizome.Nature and flavor are pungent; Temperature.Merit can warming the lung to eliminate phlegm; Expelling wind and removing dampness; Regulating QI to relieve pain.

Flos Helianthi is the flower of feverfew Helianthi Helianthus annuus L..Taste is micro-sweet; Property is put down.Merit can be dispeled the wind; Suppressing the hyperactive liver; Dampness removing.

Herba Taxilli: be the stem and branch with leaf of Loranthaceae evergreen dwarf shrub plant Herba Taxilli Loranthusparasiticus (L.) Merr. or Herba Visci Viscumcoloratum (Komar.) Nakai.Nature and flavor bitter, sweet, flat.Return liver, kidney channel.Effect: wind-damp dispelling, liver and kidney tonifying, bone and muscle strengthening." Japan hanako materia medica ": help muscles and bones, beneficial blood vessels.

Stir-fried kidney beans is the dry mature seed of pulse family Dolichos plant Seem Lablab Album, and fry to micro-yellow, the used time smashs to pieces.Nature and flavor are sweet, tepor.Return spleen, stomach warp.Merit can invigorating the spleen for eliminating dampness, and in relieve summer heat.

Cortex Betulae Luminiferae is the bark of Betulaceae betula luminifera Betula luminifera H.Win Flos jasmini.Nature and flavor are sweet; Pungent; Slightly warm in nature.Merit can damp eliminating cold expelling; Disappear stagnant and in, removing toxic substances.

Rhizoma Fagopyri Dibotryis stem and leaf is the stem and leaf of polygonaceae plant Rhizoma Fagopyri Dibotryis Fagopyrum dibotrys (D.Don) Hara.Nature and flavor are bitter, pungent, cool in nature.Return lung, spleen, Liver Channel.Merit can heat-clearing and toxic substances removing, invigorating spleen to remove dampness, dispelling wind and removing obstruction in the collateral.

Semen Coicis: enter spleen, lung, kidney channel.Spleen invigorating, tonifying the lung, heat clearing away, dampness removing.Control and have loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea.

Herba Leonuri: acrid-sweet flavor, feeble QI temperature, nontoxic.Enter the heart, liver, urinary bladder channel.Invigorate blood circulation, blood stasis dispelling, regulating menstruation, disappear water.Control menoxenia, vaginal bleeding during pregnancy is had difficult labour, and retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.

Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to latus rectum of invigorating blood circulation, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converge with speech ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, tune blood also.Main tire produces all kinds of diseases and ailments because blood is for suffering from, or blood is tired of bruise, and coma in silence; Or lochia robs the heart, umbilicus angina abdominis; Or drop slurry is difficult raw; Or afterbirth does not fall, dead fetus in the uterus, be all just before giving birth all cards, non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters blood room, delirium is gone mad; Or blood is vexed interior swollen, sudden syncope with rigidity as extremely, be all puerperal all cards, non-Flos Carthami can not be determined.All as obstructed in amenorrhea and cold and heat are handed over and are done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood are amassed, or skin infection sufferings and swollen burst uneasy, be the card of all disharmony between QI and blood, non-Flos Carthami can not be adjusted, Flos Carthami promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, there are inhibition thrombosis, antiinflammatory, analgesic effect, there is the vasoconstrictive effect eliminating epinephrine, norepinephrine, have " tonneau passages through which vital energy circulates " to act on.

Radix Puerariae, sweet in the mouth, pungent, cool in nature.Enter spleen, stomach warp.There is yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, effect that relieving restlessness is only warm.For typhoid fever, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery, and skin eruption is not saturating, hypertension, and angina pectoris is deaf.Be used for Hypertension neck pain, angina pectoris clinically, but also there is hypoglycemic activity.

Modern medicine is thought, shiver with cold after idiopathic general anesthesia (PS) shivers with cold different from other, not only without the high heat of secondary, also shows as central body temperature simultaneously and declines.In wind and cold disease, the reason of shiver with cold heating is that cold-evil visitor to defend point in flesh table, and can not traffic inside and outside the negative and positive of PS to be anaesthetic cause physiological status, be embodied in Yuanyang and lie prostrate in Shao Yin, yang-energy is hindered, defend gas not with flourish phase-splitting and, seek the gas defended and can not thoroughly reach caused by flesh table.Wind and cold disease is with cold expelling medicine divergence cold-evil of inducing sweat with except shiver with cold, but if PS uses relieving the exterior syndrome with drugs of pungent in flavor and warm in nature medicine, then lunar first YANG deficiency, lets out when Tibetan is counter, or becomes his disease raw.Therefore its prevention, should with inside and outside traffic, resolving mass and removing the obstruction of the collateral, consolidate heat clearing away and go forward side by side.

In pharmaceutical composition of the present invention, nine layers of wind is enriched blood, invigorate blood circulation, dredging collateral, Caulis Entadae clearing away heat-damp and promoting diuresis, promoting blood circulation to remove obstruction in the collateral, Retinervus Luffae Fructus dredging collateral, invigorate blood circulation, dispel the wind, nine layers of wind, Caulis Entadae, Retinervus Luffae Fructus share, and jointly reaching enriches blood invigorates blood circulation, the effect of activating qi and collateral, is monarch drug.Herba Changnieniae amoenae heat clearing away, removing heat from blood, removing toxic substances, Spina Gleditsiae detumescence poison holding, evacuation of pus, parasite killing, Caulis Trachelospermi dispelling wind and removing obstruction in the collateral, removing heat from blood is subsided a swelling, Rhizoma Cimicifugae elevate a turnable ladder yang-energy, auxiliary Spina Gleditsiae lifts yang-energy, Fructus cinnamomi immaturus warming spleen and stomach for dispelling cold, Flos Helianthi dispels the wind, suppressing the hyperactive liver, dampness removing, and all medicines share, and is ministerial drug.Flos jasmini, large Herba Swertiae heteranthae promoting the circulation of QI to relieve pain, Flos jasmini can the spasm that causes of antagonism acetylcholine, has Bronchial Relaxation effect, Radix Ranunculi Ternati eliminating stagnation, detumescence, Cortex Betulae Luminiferae damp eliminating cold expelling, disappear stagnant and in, Rhizoma Fagopyri Dibotryis stem and leaf heat-clearing and toxic substances removing, invigorating spleen to remove dampness, dispelling wind and removing obstruction in the collateral, Herba Taxilli wind-damp dispelling, liver and kidney tonifying, bone and muscle strengthening, stir-fried kidney beans invigorating the spleen for eliminating dampness, Radix Puerariae yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal is adjuvant drug.Semen Coicis spleen invigorating, tonifying the lung, heat clearing away, dampness removing, Herba Leonuri is invigorated blood circulation, blood stasis dispelling, Flos Carthami promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, for making medicine.All medicines are coordinated mutually, and traffic is inside and outside, resolving mass and removing the obstruction of the collateral, consolidate heat clearing away, effectively reach the object of prevention PS, and side effect is less.

Neurosurgery of the present invention preoperative intervention pharmaceutical composition compatibility meets Chinese medicine " monarch " principle, prepares easy, and medicine source is extensive, and with low cost, its determined curative effect, toxic and side effects are little, are suitable for wide popularization and application.

Detailed description of the invention

For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with embodiment, technical scheme of the present invention is clearly and completely described.Obviously, described embodiment is a part of the present invention, instead of whole embodiments.Based on described embodiments of the invention, the every other embodiment that those of ordinary skill in the art obtain under without the need to the prerequisite of creative work, all belongs to the scope of protection of the invention.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.

Embodiment 1:

The preoperative intervention pharmaceutical composition of a kind of neurosurgery of the present invention, gets following traditional Chinese medicine raw medicine: nine layers of wind 12 grams, Fructus cinnamomi immaturus 16 grams, Semen Coicis 3 grams, Herba Changnieniae amoenae 12 grams, Rhizoma Cimicifugae 12 grams, Spina Gleditsiae 10 grams, 9 grams, Flos Carthami, Retinervus Luffae Fructus 15 grams, Radix Ranunculi Ternati 15 grams, Caulis Trachelospermi 8 grams, large Herba Swertiae heteranthae 5 grams, Caulis Entadae 3 grams, Flos Helianthi 14 grams, Herba Taxilli 9 grams, Flos jasmini 6 grams, stir-fried kidney beans 8 grams, Herba Leonuri 5 grams, Rhizoma Fagopyri Dibotryis stem and leaf 1 gram, Cortex Betulae Luminiferae 1 gram, Radix Puerariae 10 grams.

The preparation method of described Chinese medicine composition is:

(1) get each medical material of components by weight percent in described Chinese medicine composition, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decocts 1 hour: second time adds the water of 8 times amount, decocts 1h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24 hours, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) pulverized by dry extract obtained for step (2), add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule.

Embodiment 2:

The preoperative intervention pharmaceutical composition of a kind of neurosurgery of the present invention, gets following traditional Chinese medicine raw medicine: nine layers of wind 20 grams, Fructus cinnamomi immaturus 10 grams, Semen Coicis 8 grams, Herba Changnieniae amoenae 5 grams, Rhizoma Cimicifugae 17 grams, Spina Gleditsiae 12 grams, 4 grams, Flos Carthami, Retinervus Luffae Fructus 20 grams, Radix Ranunculi Ternati 10 grams, Caulis Trachelospermi 12 grams, large Herba Swertiae heteranthae 2 grams, Caulis Entadae 7 grams, Flos Helianthi 11 grams, Herba Taxilli 15 grams, Flos jasmini 3 grams, stir-fried kidney beans 13 grams, Herba Leonuri 3 grams, Rhizoma Fagopyri Dibotryis stem and leaf 3 grams, Cortex Betulae Luminiferae 3 grams, Radix Puerariae 5 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) get each medical material of components by weight percent in described Chinese medicine composition, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decocts 1-2 hour: second time adds the water of 12 times amount, decocts 1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) dry extract that step (2) is obtained be dry, pulverize, make powder.

Embodiment 3:

The preoperative intervention pharmaceutical composition of a kind of neurosurgery of the present invention, gets following traditional Chinese medicine raw medicine: nine layers of wind 13 grams, Fructus cinnamomi immaturus 11 grams, Semen Coicis 4 grams, Herba Changnieniae amoenae 6 grams, Rhizoma Cimicifugae 13 grams, Spina Gleditsiae 7 grams, 5 grams, Flos Carthami, Retinervus Luffae Fructus 18 grams, Radix Ranunculi Ternati 11 grams, Caulis Trachelospermi 9 grams, large Herba Swertiae heteranthae 4 grams, Caulis Entadae 6 grams, Flos Helianthi 12 grams, Herba Taxilli 13 grams, Flos jasmini 4 grams, stir-fried kidney beans 9 grams, Herba Leonuri 4 grams, Rhizoma Fagopyri Dibotryis stem and leaf 2 grams, Cortex Betulae Luminiferae 2 grams, Radix Puerariae 6 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) get each medical material of components by weight percent in described Chinese medicine composition, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decocts 1-2 hour: second time adds the water of 8-12 times amount, decocts 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.15;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 48 hours, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) dry extract obtained for step (2) is pulverized, add appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule.

Embodiment 4:

The preoperative intervention pharmaceutical composition of a kind of neurosurgery of the present invention, gets following traditional Chinese medicine raw medicine: nine layers of wind 17 grams, Fructus cinnamomi immaturus 15 grams, Semen Coicis 7 grams, Herba Changnieniae amoenae 11 grams, Rhizoma Cimicifugae 16 grams, Spina Gleditsiae 8 grams, 8 grams, Flos Carthami, Retinervus Luffae Fructus 16 grams, Radix Ranunculi Ternati 14 grams, Caulis Trachelospermi 11 grams, large Herba Swertiae heteranthae 3 grams, Caulis Entadae 5 grams, Flos Helianthi 13 grams, Herba Taxilli 14 grams, Flos jasmini 5 grams, stir-fried kidney beans 12 grams, Herba Leonuri 3 grams, Rhizoma Fagopyri Dibotryis stem and leaf 1 gram, Cortex Betulae Luminiferae 1 gram, Radix Puerariae 10 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) get each medical material of components by weight percent in described Chinese medicine composition, first time decocts the water boiling and extraction adding 15 times of medical material gross weight, decocts 1-2 hour: second time adds the water of 8-12 times amount, decocts 1-1.2h, leaches medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10-1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) dry extract obtained for step (2) is pulverized, add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet.

Embodiment 5:

The preoperative intervention pharmaceutical composition of a kind of neurosurgery of the present invention, gets following traditional Chinese medicine raw medicine: nine layers of wind 15 grams, Fructus cinnamomi immaturus 12 grams, Semen Coicis 5 grams, Herba Changnieniae amoenae 9 grams, Rhizoma Cimicifugae 15 grams, Spina Gleditsiae 9 grams, 7 grams, Flos Carthami, Retinervus Luffae Fructus 19 grams, Radix Ranunculi Ternati 13 grams, Caulis Trachelospermi 10 grams, large Herba Swertiae heteranthae 4 grams, Caulis Entadae 4 grams, Flos Helianthi 11 grams, Herba Taxilli 11 grams, Flos jasmini 5 grams, stir-fried kidney beans 10 grams, Herba Leonuri 5 grams, Rhizoma Fagopyri Dibotryis stem and leaf 3 grams, Cortex Betulae Luminiferae 3 grams, Radix Puerariae 8 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) get each medical material of components by weight percent in described Chinese medicine composition, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decocts 1.5 hours: second time adds the water of 8 times amount, decocts 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10-1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) to above-mentioned steps (2) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

Embodiment 6:

The preoperative intervention pharmaceutical composition of a kind of neurosurgery of the present invention, gets following traditional Chinese medicine raw medicine: nine layers of wind 19 grams, Fructus cinnamomi immaturus 14 grams, Semen Coicis 6 grams, Herba Changnieniae amoenae 7 grams, Rhizoma Cimicifugae 14 grams, Spina Gleditsiae 9 grams, 6 grams, Flos Carthami, Retinervus Luffae Fructus 17 grams, Radix Ranunculi Ternati 13 grams, Caulis Trachelospermi 10 grams, large Herba Swertiae heteranthae 4 grams, Caulis Entadae 4 grams, Flos Helianthi 11 grams, Herba Taxilli 11 grams, Flos jasmini 5 grams, stir-fried kidney beans 10 grams, Herba Leonuri 5 grams, Rhizoma Fagopyri Dibotryis stem and leaf 3 grams, Cortex Betulae Luminiferae 3 grams, Radix Puerariae 8 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) get each medical material of components by weight percent in described Chinese medicine composition, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decocts 1.2 hours: second time adds the water of 8-12 times amount, decocts 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10-1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) to above-mentioned steps (2) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

Acute toxicity test:

Get mice 60, body weight 22-25 gram, to mouse stomach capsule solution, test determination has been carried out to the median lethal dose(LD 50) (LD50) of administration, but has not measured LD50, because this has been mtd test.Result: with maximum dosage-feeding 120g/kg gavage, 280 times of the daily dosage of clinical plan that is equivalent to be grown up, in seven days mice none is dead, put to death each internal organs of mice anatomic observation and do not find toxic reaction, administration group and control group mice are without any difference.

Six months long term toxicity tests: get rat 60, body weight 180 ~ 220g, Experimental agents is set as high, medium and low three dosage, be respectively capsule 40g/kg, 20g/kg, 10g/kg, within dosage 1.1g/kg/ days, calculate with (75kg is standard) by people, be 40 times, 20 times and 10 times of people's effective dose; Separately establish a matched group, continuous gastric infusion 90 days, 180 days and Some Animals drug withdrawal, after 10 days, observe the impact on the every physiology of rat, biochemical indicator.Experimental result shows: by various dose to rat continuous oral 180 days, increases all without affecting the food-intake of rat and body weight.Overt toxicity effect is not all found to hepatic and renal function.Obvious impact is showed no on routine blood test, blood biochemistry, urine biochemistry and bone marrow sheet etc., between each group, compares no significant difference with matched group.

Clinical reasoning:

In order to verify the effect of pharmaceutical composition of the present invention, in May ,-2014 in October, 2012, Patients after Receiving Craniocerebral Operation under 120 routine neurosurgery general anesthesias is randomly drawed in outpatient service place, and does not use the medicine of the treatment shiver with colds such as ondansetron, tramadol, clonidine in preoperative 3 days.Operation reason comprises: Supratentorial neoplasms 31 example, PFT 16 example, tumor of ventricle 8 example, and cerebrovascular 11 is routine, pituitary tumor 20 example, craniopharyngioma 2 example, epilepsy surgery 3 example, and other operations are as routine in hydrocephalus, skull repairing etc. 29.Age, 39.1 ± 5.6 years old mean age, wherein male patient 57 example, female patient 63 was routine between 21 ~ 71 years old.Be divided into treatment group and matched group at random, wherein treatment group male patient 27 example, female patient 33 example, 38.7 ± 5.1 years old mean age, matched group male patient 30 example, female patient 30 example, 40.1 ± 7.8 years old mean age, 2 groups of sexes, age, courses of disease etc. compare, and difference there are no significant meaning (P > 0.05), has comparability.

Therapeutic Method:

The conventional preoperative and postoperative administration of matched group, is incubated by skin.Treatment group is on the basis of matched group, and from preoperative three days, respectively with the granule of preparation in the embodiment of the present invention 1, an oral 10mg, three times on the one, added up to three days.

Interpretation of result:

In postoperative 5 hours, PS incidence rate is respectively: matched group 45% (27/60), treatment group 6.67% (4/60).Treatment group shiver with cold incidence rate is starkly lower than matched group.

Two groups of other recovery rooms of patient (PACU) complication compare: see the following form,

Matched group, treatment group be no significant difference in cardiovascular related complication, Digestive complication, spirit complication, respiratory complication, Delayed recovery.

Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.

Claims (10)

1. the preoperative intervention pharmaceutical composition of neurosurgery, is characterized in that: the crude drug of described pharmaceutical composition is made up of nine layers of wind, Fructus cinnamomi immaturus, Herba Changnieniae amoenae, Spina Gleditsiae, Rhizoma Cimicifugae, Flos jasmini, Caulis Entadae, Retinervus Luffae Fructus, Radix Ranunculi Ternati, Caulis Trachelospermi, large Herba Swertiae heteranthae, Flos Helianthi, Herba Taxilli, stir-fried kidney beans, Cortex Betulae Luminiferae, Rhizoma Fagopyri Dibotryis stem and leaf, Semen Coicis, Herba Leonuri, Flos Carthami, Radix Puerariae.

2. the preoperative intervention pharmaceutical composition of neurosurgery according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: nine layers of wind 12-20 part, Fructus cinnamomi immaturus 10-16 part, Semen Coicis 3-8 part, Herba Changnieniae amoenae 5-12 part, Rhizoma Cimicifugae 12-17 part, Spina Gleditsiae 7-12 part, Flos Carthami 4-9 part, Retinervus Luffae Fructus 15-20 part, Radix Ranunculi Ternati 10-15 part, Caulis Trachelospermi 8-12 part, large Herba Swertiae heteranthae 2-5 part, Caulis Entadae 3-7 part, Flos Helianthi 11-14 part, Herba Taxilli 9-15 part, Flos jasmini 3-6 part, stir-fried kidney beans 8-13 part, Herba Leonuri 3-5 part, Rhizoma Fagopyri Dibotryis stem and leaf 1-3 part, Cortex Betulae Luminiferae 1-3 part, Radix Puerariae 5-10 part.

3. the preoperative intervention pharmaceutical composition of neurosurgery according to claim 1, is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: nine layers of wind 12 parts, Fructus cinnamomi immaturus 16 parts, Semen Coicis 3 parts, Herba Changnieniae amoenae 12 parts, Rhizoma Cimicifugae 12 parts, Spina Gleditsiae 10 parts, 9 parts, Flos Carthami, Retinervus Luffae Fructus 15 parts, Radix Ranunculi Ternati 15 parts, Caulis Trachelospermi 8 parts, large Herba Swertiae heteranthae 5 parts, Caulis Entadae 3 parts, Flos Helianthi 14 parts, Herba Taxilli 9 parts, Flos jasmini 6 parts, stir-fried kidney beans 8 parts, Herba Leonuri 5 parts, Rhizoma Fagopyri Dibotryis stem and leaf 1 part, Cortex Betulae Luminiferae 1 part, Radix Puerariae 10 parts.

4. the preoperative intervention pharmaceutical composition of neurosurgery according to claim 1, is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: nine layers of wind 20 parts, Fructus cinnamomi immaturus 10 parts, Semen Coicis 8 parts, Herba Changnieniae amoenae 5 parts, Rhizoma Cimicifugae 17 parts, Spina Gleditsiae 12 parts, 4 parts, Flos Carthami, Retinervus Luffae Fructus 20 parts, Radix Ranunculi Ternati 10 parts, Caulis Trachelospermi 12 parts, large Herba Swertiae heteranthae 2 parts, Caulis Entadae 7 parts, Flos Helianthi 11 parts, Herba Taxilli 15 parts, Flos jasmini 3 parts, stir-fried kidney beans 13 parts, Herba Leonuri 3 parts, Rhizoma Fagopyri Dibotryis stem and leaf 3 parts, Cortex Betulae Luminiferae 3 parts, Radix Puerariae 5 parts.

5. the preoperative intervention pharmaceutical composition of neurosurgery according to claim 1, is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: nine layers of wind 13 parts, Fructus cinnamomi immaturus 11 parts, Semen Coicis 4 parts, Herba Changnieniae amoenae 6 parts, Rhizoma Cimicifugae 13 parts, Spina Gleditsiae 7 parts, 5 parts, Flos Carthami, Retinervus Luffae Fructus 18 parts, Radix Ranunculi Ternati 11 parts, Caulis Trachelospermi 9 parts, large Herba Swertiae heteranthae 4 parts, Caulis Entadae 6 parts, Flos Helianthi 12 parts, Herba Taxilli 13 parts, Flos jasmini 4 parts, stir-fried kidney beans 9 parts, Herba Leonuri 4 parts, Rhizoma Fagopyri Dibotryis stem and leaf 2 parts, Cortex Betulae Luminiferae 2 parts, Radix Puerariae 6 parts.

6. the preoperative intervention pharmaceutical composition of neurosurgery according to claim 1, is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: nine layers of wind 17 parts, Fructus cinnamomi immaturus 15 parts, Semen Coicis 7 parts, Herba Changnieniae amoenae 11 parts, Rhizoma Cimicifugae 16 parts, Spina Gleditsiae 8 parts, 8 parts, Flos Carthami, Retinervus Luffae Fructus 16 parts, Radix Ranunculi Ternati 14 parts, Caulis Trachelospermi 11 parts, large Herba Swertiae heteranthae 3 parts, Caulis Entadae 5 parts, Flos Helianthi 13 parts, Herba Taxilli 14 parts, Flos jasmini 5 parts, stir-fried kidney beans 12 parts, Herba Leonuri 3 parts, Rhizoma Fagopyri Dibotryis stem and leaf 1 part, Cortex Betulae Luminiferae 1 part, Radix Puerariae 10 parts.

7. the preoperative intervention pharmaceutical composition of neurosurgery according to claim 1, is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: nine layers of wind 15 parts, Fructus cinnamomi immaturus 12 parts, Semen Coicis 5 parts, Herba Changnieniae amoenae 9 parts, Rhizoma Cimicifugae 15 parts, Spina Gleditsiae 9 parts, 7 parts, Flos Carthami, Retinervus Luffae Fructus 19 parts, Radix Ranunculi Ternati 13 parts, Caulis Trachelospermi 10 parts, large Herba Swertiae heteranthae 4 parts, Caulis Entadae 4 parts, Flos Helianthi 11 parts, Herba Taxilli 11 parts, Flos jasmini 5 parts, stir-fried kidney beans 10 parts, Herba Leonuri 5 parts, Rhizoma Fagopyri Dibotryis stem and leaf 3 parts, Cortex Betulae Luminiferae 3 parts, Radix Puerariae 8 parts.

8. the preoperative intervention pharmaceutical composition of neurosurgery according to claim 1, is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: nine layers of wind 19 parts, Fructus cinnamomi immaturus 14 parts, Semen Coicis 6 parts, Herba Changnieniae amoenae 7 parts, Rhizoma Cimicifugae 14 parts, Spina Gleditsiae 9 parts, 6 parts, Flos Carthami, Retinervus Luffae Fructus 17 parts, Radix Ranunculi Ternati 13 parts, Caulis Trachelospermi 10 parts, large Herba Swertiae heteranthae 4 parts, Caulis Entadae 4 parts, Flos Helianthi 11 parts, Herba Taxilli 11 parts, Flos jasmini 5 parts, stir-fried kidney beans 10 parts, Herba Leonuri 5 parts, Rhizoma Fagopyri Dibotryis stem and leaf 3 parts, Cortex Betulae Luminiferae 3 parts, Radix Puerariae 8 parts.

9., according to the arbitrary described preoperative intervention pharmaceutical composition of neurosurgery of claim 3-8, it is characterized in that: described pharmaceutical composition is prepared according to following method:

(1) each medical material of components by weight percent in the arbitrary described pharmaceutical composition of claim 3-8 is got, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decoct 1-2 hour: second time adds the water of 8-12 times amount, decoct 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10-1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) pulverized by dry extract obtained for step (2), add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule; Or the dry extract that step (2) is obtained dry, pulverize, and makes powder; Or dry extract obtained for step (2) is pulverized, adds appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule; Or dry extract obtained for step (2) is pulverized, adds suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet; Or to above-mentioned steps (2) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

10. the application of neurosurgery preoperative intervention pharmaceutical composition in the preoperative intervention medicine of neurosurgery as described in as arbitrary in claim 1-9.