CN110251576A

CN110251576A - A kind of Chinese medicine composition and preparation for alleviating renal colic caused by nephrolith disease and decorporation

Info

Publication number: CN110251576A
Application number: CN201910609441.4A
Authority: CN
Inventors: 魏丹霞; 袁小淋
Original assignee: Kunming Hospital of Traditional Chinese Medicine
Current assignee: Kunming Hospital of Traditional Chinese Medicine
Priority date: 2019-07-08
Filing date: 2019-07-08
Publication date: 2019-09-20

Abstract

The invention discloses renal colic caused by a kind of alleviation nephrolith disease and promote the Chinese medicine composition and its preparation of calculus discharge, the Chinese medicine composition by weight ratio, including 5 ~ 20 parts of radix bupleuri, 5 ~ 20 parts of endothelium corneum gigeriae galli, 5 ~ 20 parts of Chinese herbaceous peony, 5 ~ 20 parts of the dried immature fruit of citron orange.The composition can be prepared into various dosage forms and take.The present invention is based on the formation of nephrolith disease with deficiency of spleen and stomach, poly- heat of wetting, it is damp and hot to accumulate long, urine is endured into Shi Youguan, and the breaking-out of pain is then qi-movement disturbance, the logical drop failure of water channel is related, emphasize that Chinese medicine only has harmonizing the functional activities of vital QI, regulating fluid apssage ability rapid pain relief during urinary calculi is discharged, and makes the best use of the situation, while clearing heat and freeing strangury can promote the exclusion of calculus, it finally obtains with promoting qi circulation and relieving pain, Tonglin Paishi, releases the Chinese medicine composition that the urinary tract blocks effect.Compatibility of the present invention is scientific, reasonable, and pain is stopped stone and gone out, and the pain of the Patients with Urinary Stone such as calcium oxalate, calcium phosphate, uric acid row's stone can be effectively relieved, improve the expulsion efficiency of calculus, obtain preferable clinical therapeutic efficacy, overall clinical efficacy rate reaches 100%, and 2 weeks lithagogue rates are up to 44.87%.And it has no toxic side effect.

Description

A kind of Chinese medicine composition and preparation for alleviating renal colic caused by nephrolith disease and decorporation

Technical field

The invention belongs to technical field of traditional Chinese medicine preparation, and in particular to renal colic caused by one kind is effectively relieved because of nephrolith disease simultaneously promotees Into the Chinese medicine composition and its preparation of row's stone.

Background technique

With the development and progress of society, the raising of people's lives level, living habit, dietary structure, food safety Etc. factors all affecting health of people state, disease not multiple in the past becomes common disease, even multiple illness.Than Such as, some people are regular or eat on time earlier for a long time, or even do not eat earlier, and just over time, lithiasis has reformed into multiple Disease.Calculi in urinary system is exactly a kind of common disease and frequently-occurring disease.The disease incidence of China's stone in urinary system is 1%~5%, southern area Up to 5%~10%.Lithiasis can bring great pain once breaking out to patient, in great pain.Clinically, there are many treatments Means, for example, surgical operation, external vibration wave rubble.These means are also not suitble to all groups, also not without side-effects.Body Outer vibration wave rubble, it is possible to it affects to other organs, only says that these influence to be furtherd investigate not yet, it is modern Medical procedure or therapeutic agent or method side effect, that often studies is constantly progressive, or the side effect clinically occurred It is more, it is just found or payes attention to after the several years.All external section's medical procedure treatment calculus of people, which still have, repels psychology.In Medical treatment calculus is ancient and has it, various Paishi Tang agent, cooperates the strong movements of human body specific action, lithagogue effect or good 's.But since individual difference is larger and the type of calculus is different, of different sizes, position is different, all directly affects row Stone effect.Over the course for the treatment of, whether prescription method arrange stone, or operation after residual stone be discharged when, can all cause severe pain Unbearably or even painful is suffered a shock, greatly painful to patient's bring.This is that doctor trained in Western medicine means are insurmountable, can only take one The pain of a little analgesic drug product reduction of patient, however, Western medicine side effect is basic Consensus greatly.Chinese tradition traditional Chinese medicine is for small urinary calculi The row's stone and various mode hand postoperative residue microliths of disease (< 8mm) have certain during arranging stone the problems such as caused pain Advantage therefore seek can be effectively relieved or release twisting to patient's bring kidney according to Chinese medicine theory because of calculi in urinary system The symptoms such as pain, and can promote to arrange the Chinese medicine composition of stone to be clinically to continue problem in the urgent need to address.

Summary of the invention

The effect of the purpose of the present invention is to provide one kind to have promoting qi circulation and relieving pain, arranges stone, and it is significant in efficacy, it can be effective Alleviate renal colic caused by calculi in urinary system, and promotes to arrange the Chinese medicine composition of stone；Further provide for the Chinese medicine composition it Prepare dosage form and purposes.

The object of the present invention is achieved like this, the Chinese medicine composition by weight ratio, including 5 ~ 20 parts of radix bupleuri, 5 ~ 20 parts of endothelium corneum gigeriae galli, 5 ~ 20 parts of Chinese herbaceous peony, 5 ~ 20 parts of the dried immature fruit of citron orange.

The Chinese medicine composition except can decocting cook at decoction in addition to, medically acceptable auxiliary material, which can also be added, can be prepared into Any one in tablet, capsule, paste, syrup, granule, pulvis, powder and pill.

Alleviating renal colic caused by nephrolith disease based on Chinese medicine composition described in prescription and promoting the application in calculus discharge.

The drug alleviated renal colic caused by nephrolith disease in preparation based on Chinese medicine composition described in prescription and calculus is promoted to be discharged In application.

The Chinese medicine composition of the present invention, the radix bupleuri enter the liver channel of foot-Jueyin, pivot the machine of few sun, and endothelium corneum gigeriae galli returns kidney, bladder Through function is treating stranguria fossil, radix bupleuri and endothelium corneum gigeriae galli are monarch drug in a prescription altogether, promoting qi circulation and relieving pain are played, the effect for the treatment of stranguria fossil；The soft liver blood-nourishing of Chinese herbaceous peony Relieving spasm to stop pain, dried immature fruit of citron orange relieving stagnant Qi disperse accumulation, eliminating phlegm and dispersing mass, Chinese herbaceous peony, two medicine of the dried immature fruit of citron orange are ministerial drug altogether；Herba lysimachiae is sweet, light, returns kidney, bladder meridian, Lygodium japonicum is sweet in flavor, cold in nature, returns bladder, small intestinl channel, function clearing away heat and promoting diuresis is treating stranguria；Radix Curcumae is pungent, bitter, cold, returns liver, the heart, lung channel, function Promoting qi circulation and removing obstruction in the collateral, clear away heart-fire cool blood, promoting blood circulation and stopping pain, its property of Radix Curcumae lightly floats, and can dissipate stasis, reaches high mountain peak on suitable inverse gas, burnt under benefaction, three medicines It is altogether adjutant, makes the best use of the situation, promotes row's stone；Radix Glycyrrhizae relieving spasm to stop pain, reconciling all is to make medicine.All medicines share, mechanism of qi is suitable, and water channel is logical, Clearing moist heat, calculus go out.

The present invention is based on the formation of nephrolith disease with deficiency of spleen and stomach, and poly- heat of wetting is damp and hot to accumulate long, endures urine into Shi Youguan, and aches The breaking-out of pain is then qi-movement disturbance, and the logical drop failure of water channel is related, emphasizes there was only harmonizing the functional activities of vital QI, tonneau during urinary calculi is discharged Water channel ability rapid pain relief, makes the best use of the situation, while clearing heat and freeing strangury can promote the exclusion of calculus, finally obtains with promoting the circulation of qi Analgesic, Tonglin Paishi release the Chinese medicine composition that the urinary tract blocks effect.Compatibility of the present invention is scientific, reasonable, monarch-minister drug complex group Side, the both abundant Action advantage of each flavour of a drug were more conducive to transfer between flavour of a drug and acted synergistically, treatment calcium oxalate, calcium phosphate, uric acid The pain of patient can be effectively relieved in equal stone in urinary system, improve the expulsion efficiency of calculus, obtain preferable clinical therapeutic efficacy；No Only quick and significant in efficacy, overall clinical efficacy rate reaches 100%, and 2 weeks lithagogue rates are up to 44.87%.And it has no toxic side effect.This Invention Chinese medicine composition can be prepared into a variety of different dosage forms, and preparation method is simple and easy to do, mild condition, and stability is good.

Specific embodiment

Below with reference to embodiment, the present invention is further illustrated, but the present invention is limited in any way, Training centre does any improvement and all belongs to the scope of protection of the present invention according to the present invention.

One kind of the present invention can be effectively relieved renal colic caused by nephrolith disease and promote the Chinese medicine composition of calculus discharge, described Chinese medicine composition by weight ratio, including 5 ~ 20 parts of radix bupleuri, 5 ~ 20 parts of endothelium corneum gigeriae galli, 5 ~ 20 parts of Chinese herbaceous peony, 5 ~ 20 parts of the dried immature fruit of citron orange.

It include 8 ~ 15 parts of radix bupleuri, 8 ~ 15 parts of endothelium corneum gigeriae galli, 8 ~ 15 parts of Chinese herbaceous peony, 8 ~ 15 parts of the dried immature fruit of citron orange in the Chinese medicine composition.

It include 9 ~ 12 parts of radix bupleuri, 9 ~ 12 parts of endothelium corneum gigeriae galli, 9 ~ 12 parts of Chinese herbaceous peony, 9 ~ 12 parts of the dried immature fruit of citron orange in the Chinese medicine composition.

Also contain 8 ~ 15 parts of herba lysimachiae, 5 ~ 15 parts of Lygodium japonicum, 5 ~ 15 parts of Radix Curcumae or Radix Glycyrrhizae 5 ~ 10 in the Chinese medicine composition Part one of or more than one.

Also contain 8 ~ 15 parts of herba lysimachiae, 8 ~ 12 parts of Lygodium japonicum, 8 ~ 12 parts of Radix Curcumae or Radix Glycyrrhizae 6 ~ 8 in the Chinese medicine composition Part one of or more than one.

The Chinese medicine composition except can decocting cook at decoction in addition to, medically acceptable auxiliary material, which can also be added, can be prepared into Any one in tablet, capsule, paste, syrup, granule, pulvis, powder and/or pill.

The syrup of the Chinese medicine composition is prepared by following procedures: each prescription is added 2 ~ 5 times of amount 50- by weight 70 DEG C of water are cooked by slow fire 3 times after impregnating 5-30min, and 5 ~ 20min, merging filtrate, normal temperature and pressure are concentrated into 300 ~ 400ml every time, 50 ~ 100g honey, sucrose etc. is added and is prepared into syrup.

The granule of the Chinese medicine composition is prepared in the following manner: each prescription being crushed to 60 ~ 100 mesh, by weight Amount is cooked by slow fire 2 times, every time 5 ~ 25min, merging filtrate, filtrate is concentrated into relative density 1.21 ~ 1.25 than adding 2 ~ 5 times of amount water (80 DEG C)；60-70 DEG C is dried under vacuum to constant weight, and dry cream is crushed to 60-80 mesh, and 0.6 times of dextrin is added by dried cream powder weight ratio, 0.4 times of soluble starch uniformly mixes, and using suitable water as wetting agent, carries out wet granulation, 60-65 DEG C of drying, whole grain After be prepared into granule.

The capsule of the Chinese medicine composition is prepared by following process: each prescription being crushed to 60 ~ 100 mesh, by weight Amount is cooked by slow fire 2 times, every time 5 ~ 25min, merging filtrate, filtrate is concentrated into relative density 1.21 ~ 1.25 than adding 2 ~ 5 times of amount water (80 DEG C)；60-70 DEG C is dried under vacuum to constant weight, and dry cream is crushed to 60-80 mesh, and 0.6 times of dextrin is added by dried cream powder weight ratio, 0.4 times of soluble starch uniformly mixes, and using suitable water as wetting agent, carries out wet granulation, 70-80 DEG C of dry 45- 60min crosses 20-40 mesh, is packed into No. 0 capsule and is prepared into capsule.

Chinese medicine composition based on renal colic caused by alleviation nephrolith disease described in prescription and decorporation is in treatment because of urinary system The application of renal colic disease caused by calculus.

Embodiment 1

It is paid by weight with decoction one, radix bupleuri 5g, endothelium corneum gigeriae galli 5g, Chinese herbaceous peony 5g, dried immature fruit of citron orange 5g, is mixed by prescription, impregnated with 5 times of water 5min, water decoct 20 minutes, and it is spare to filter out medical fluid；The dregs of a decoction add 3 times of water again, and water decocts 10min, filter out medical fluid and first time medicine Liquid merges spare；The dregs of a decoction add 2 times of water again, and water decocts 10min, filters out medical fluid and merges with preceding medical fluid twice, it is concentrated into 250 ~ 300ml, as 3 doses.

Embodiment 2

It is paid by weight, radix bupleuri 20g, endothelium corneum gigeriae galli 20g, Chinese herbaceous peony 20g, dried immature fruit of citron orange 20g, is mixed by prescription, with 5 times of water loggings with decoction one 5min is steeped, water decocts 20 minutes, and it is spare to filter out medical fluid；The dregs of a decoction add 4 times of water again, and water decocts 10min, filter out medical fluid and first time Medical fluid merges spare；The dregs of a decoction add 3 times of water again, and water decocts 10min, filters out medical fluid and merges with preceding medical fluid twice, it is concentrated into 500 ~ 600ml, as 6 doses.

Embodiment 3

It is paid by weight, radix bupleuri 15g, endothelium corneum gigeriae galli 15g, Chinese herbaceous peony 15g, dried immature fruit of citron orange 15g, is mixed by prescription, with 3 times of water loggings with decoction one 5min is steeped, water decocts 20 minutes, and it is spare to filter out medical fluid；The dregs of a decoction add 3 times of water again, and water decocts 10min, filter out medical fluid and first time Medical fluid merges spare；The dregs of a decoction add 2 times of water again, and water decocts 10min, filters out medical fluid and merges with preceding medical fluid twice, it is concentrated into 250 ~ 400ml, as 3 ~ 4 doses.

Embodiment 4

It is paid by weight with decoction one, radix bupleuri 8g, endothelium corneum gigeriae galli 8g, Chinese herbaceous peony 8g, dried immature fruit of citron orange 8g, is mixed by prescription, impregnated with 3 times of water 5min, water decoct 20 minutes, and it is spare to filter out medical fluid；The dregs of a decoction add 3 times of water again, and water decocts 10min, filter out medical fluid and first time medicine Liquid merges spare；The dregs of a decoction add 2 times of water again, and water decocts 10min, filters out medical fluid and merges with preceding medical fluid twice, it is concentrated into 300 ~ 450ml, as 4 ~ 5 doses.

Embodiment 5

It is paid by weight, radix bupleuri 9g, endothelium corneum gigeriae galli 9g, Chinese herbaceous peony 9g, dried immature fruit of citron orange 9g, herba lysimachiae 8g, is mixed by prescription, with 4 with decoction one Times water impregnates 5min, and water decocts 15 minutes, and it is spare to filter out medical fluid；The dregs of a decoction add 3 times of water again, and water decocts 15min, filter out medical fluid with First time medical fluid merges spare；The dregs of a decoction add 3 times of water again, and water decocts 10min, filter out medical fluid and merge with preceding medical fluid twice, are concentrated To 300 ~ 450ml, as 3 ~ 5 doses.

Embodiment 6

It is paid by weight with decoction one, radix bupleuri 12g, endothelium corneum gigeriae galli 12g, Chinese herbaceous peony 12g, dried immature fruit of citron orange 12g, herba lysimachiae 15g, Lygodium japonicum 15g, It is mixed by prescription, impregnates 5min with 4 times of water, water decocts 10 minutes, and it is spare to filter out medical fluid；The dregs of a decoction add 3 times of water again, and water decocts 15min, filter out medical fluid merge with first time medical fluid it is spare；The dregs of a decoction add 2 times of water again, and water decocts 10min, filter out medical fluid and preceding two Secondary medical fluid merges, and 300 ~ 400ml is concentrated into, as 3 ~ 4 doses.

Embodiment 7

It is paid by weight with decoction one, radix bupleuri 15g, endothelium corneum gigeriae galli 10g, Chinese herbaceous peony 15g, dried immature fruit of citron orange 10g, Lygodium japonicum 15g, Radix Curcumae 15g is pressed Prescription mixing impregnates 5min with 5 times of water, and water decocts 20 minutes, and it is spare to filter out medical fluid；The dregs of a decoction add 4 times of water again, and water decocts 15min, filter out medical fluid merge with first time medical fluid it is spare；The dregs of a decoction add 3 times of water again, and water decocts 10min, filter out medical fluid and preceding two Secondary medical fluid merges, and 300 ~ 450ml is concentrated into, as 4 ~ 5 doses.

Embodiment 8

It is paid by weight with decoction one, radix bupleuri 12g, endothelium corneum gigeriae galli 10g, Chinese herbaceous peony 15g, dried immature fruit of citron orange 10g, Lygodium japonicum 15g, Radix Curcumae 15g is sweet Careless 5g is mixed by prescription, impregnates 5min with 3 times of water, and water decocts 15 minutes, and it is spare to filter out medical fluid；The dregs of a decoction add 3 times of water again, decocting Boil 15min, filter out medical fluid merge with first time medical fluid it is spare；The dregs of a decoction add 2 times of water again, and water decocts 10min, filter out medical fluid with before Medical fluid merges twice, 300 ~ 400ml is concentrated into, as 3 ~ 4 doses.

Embodiment 9

It is paid by weight with decoction one, radix bupleuri 15g, endothelium corneum gigeriae galli 10g, Chinese herbaceous peony 20g, dried immature fruit of citron orange 10g, herba lysimachiae 15g, Radix Curcumae 15g is sweet Careless 10g is mixed by prescription, impregnates 5min with 4 times of water, and water decocts 20 minutes, and it is spare to filter out medical fluid；The dregs of a decoction add 3 times of water again, water Decoct 15min, filter out medical fluid merge with first time medical fluid it is spare；The dregs of a decoction add 2 times of water again, and water decocts 10min, filter out medical fluid with Preceding medical fluid twice merges, and 350 ~ 450ml is concentrated into, as 4 ~ 5 doses.

Embodiment 10

It is paid by weight with decoction one, radix bupleuri 9g, endothelium corneum gigeriae galli 5g, Chinese herbaceous peony 15g, dried immature fruit of citron orange 10g, herba lysimachiae 10g, Radix Curcumae 10g presses group Side's mixing impregnates 5min with 4 times of water, and water decocts 20 minutes, and it is spare to filter out medical fluid；The dregs of a decoction add 3 times of water again, and water decocts 15min, Filter out medical fluid merge with first time medical fluid it is spare；The dregs of a decoction add 2 times of water again, and water decocts 10min, filter out medical fluid and preceding medical fluid twice Merge, 350 ~ 450ml is concentrated into, as 4 ~ 5 doses.

Embodiment 11

It is paid by weight with decoction one, radix bupleuri 15g, endothelium corneum gigeriae galli 10g, Chinese herbaceous peony 15g, dried immature fruit of citron orange 8g, herba lysimachiae 15g, Lygodium japonicum 15g, Radix Glycyrrhizae 10g is mixed by prescription, impregnates 5min with 4 times of water, and water decocts 20 minutes, and it is spare to filter out medical fluid；The dregs of a decoction add 3 times of water again, Water decoct 15min, filter out medical fluid merge with first time medical fluid it is spare；The dregs of a decoction add 2 times of water again, and water decocts 10min, filter out medical fluid Merge with preceding medical fluid twice, be concentrated into 350 ~ 450ml, as 4 ~ 5 doses.

Embodiment 12

It is paid by weight with decoction one, radix bupleuri 10g, endothelium corneum gigeriae galli 15g, Chinese herbaceous peony 15g, dried immature fruit of citron orange 15g, herba lysimachiae 15g, Radix Glycyrrhizae 10g is pressed Prescription mixing impregnates 5min with 4 times of water, and water decocts 20 minutes, and it is spare to filter out medical fluid；The dregs of a decoction add 3 times of water again, and water decocts 15min, filter out medical fluid merge with first time medical fluid it is spare；The dregs of a decoction add 2 times of water again, and water decocts 10min, filter out medical fluid and preceding two Secondary medical fluid merges, and 350 ~ 450ml is concentrated into, as 4 ~ 5 doses.

Embodiment 13

It is paid by weight with decoction one, radix bupleuri 10g, endothelium corneum gigeriae galli 10g, Chinese herbaceous peony 10g, dried immature fruit of citron orange 8g, herba lysimachiae 15g, Lygodium japonicum 15g, Radix Curcumae 10g is mixed by prescription, impregnates 5min with 4 times of water, and water decocts 20 minutes, and it is spare to filter out medical fluid；The dregs of a decoction add 3 times of water again, Water decoct 15min, filter out medical fluid merge with first time medical fluid it is spare；The dregs of a decoction add 2 times of water again, and water decocts 10min, filter out medical fluid Merge with preceding medical fluid twice, be concentrated into 300 ~ 400ml, as 3 ~ 4 doses.

Embodiment 14

It being paid by weight with decoction one, radix bupleuri 12g, endothelium corneum gigeriae galli 12g, Chinese herbaceous peony 12g, dried immature fruit of citron orange 10g, Radix Curcumae 15g is mixed by prescription, with 3 times of water impregnate 5min, and water decocts 15 minutes, and it is spare to filter out medical fluid；The dregs of a decoction add 3 times of water again, and water decocts 15min, filter out medical fluid Merge with first time medical fluid spare；The dregs of a decoction add 2 times of water again, and water decocts 10min, filters out medical fluid and merges with preceding medical fluid twice, dense It is reduced to 300 ~ 400ml, as 3 ~ 4 doses.

Embodiment 15

It is paid by weight with decoction one, radix bupleuri 12g, endothelium corneum gigeriae galli 10g, Chinese herbaceous peony 12g, dried immature fruit of citron orange 10g, Radix Glycyrrhizae 5g is mixed by prescription, with 3 Times water impregnates 5min, and water decocts 15 minutes, and it is spare to filter out medical fluid；The dregs of a decoction add 3 times of water again, and water decocts 15min, filter out medical fluid with First time medical fluid merges spare；The dregs of a decoction add 2 times of water again, and water decocts 10min, filter out medical fluid and merge with preceding medical fluid twice, are concentrated To 300 ~ 400ml, as 3 ~ 4 doses.

Embodiment 16

It being paid by weight with decoction one, radix bupleuri 10g, endothelium corneum gigeriae galli 10g, Chinese herbaceous peony 15g, dried immature fruit of citron orange 5g, Lygodium japonicum 15g is mixed by prescription, 5min is impregnated with 3 times of water, water decocts 15 minutes, and it is spare to filter out medical fluid；The dregs of a decoction add 3 times of water again, and water decocts 15min, filter out medicine Liquid merges spare with first time medical fluid；The dregs of a decoction add 2 times of water again, and water decocts 10min, filter out medical fluid and merge with preceding medical fluid twice, It is concentrated into 300 ~ 400ml, as 3 ~ 4 doses.

After the decoction of the above various embodiments can be condensed into thick paste (relative density 1.0 ~ 1.25), according to preparing different dosage forms Needs, medically acceptable auxiliary material can be added according to a conventional method and be prepared into different dosage forms.Tablet, capsule, cream Agent, syrup, granule, pulvis, powder and/or pill.

The medically acceptable auxiliary material includes but is not limited to: medicinal dextrin, starch, sucrose, honey；Crystallite is fine Tie up element, stearic acid, magnesium stearate；Pharmagel；Sodium carboxymethyl starch, sodium carboxymethylcellulose, soluble starch, mannitol Deng.

Experimental example 1

1, essential information

45 patients of stone in urinary system are treated altogether with we between inventor in December, 2017 ~ 2019 year Mays, wherein male 28, Women 17；It is the oldest 68 years old, 19 years old minimum, it is 42 ± 12.26 years old average；Kidney stone single-shot 24, multiple 11, kidney knot Stone is multiple and ureteral calculi 8, simple ureteral calculi 2；Calculus sum 78, maximum calculus diameter 1.1cm, most brief summary Stone 0.3cm, average 0.68 ± 0.13cm；Acute renal colic is 18 medical, common 27 medical；45 patients occur during arranging stone Renal colic 26 times.

2, stone in urinary system diagnoses

The diagnosis of 2.1 doctors trained in Western medicine

All 45 sufferers pass through ultrasound diagnosis, wherein 15 do plain abdominal radiograph, 8 do renal phlebography, renal colic Uroscopy red blood cell is in 2⁺~3⁺Person 39.

2.2 tcm diagnosis

2.2.1 waist eilema, difficulty and pain in micturition, band blood in urine, or urination are interrupted, and shouting pain is unbearably when solution.Yellowish fur, veins string or Number.

2.2.2 the visible blood urine of naked eyes or urine have sandstone discharge.

2.2.3 routine urianlysis has red blood cell.

3, treatment method

Treatment group takes orally granule (radix bupleuri 10g, endothelium corneum gigeriae galli 10g, Chinese herbaceous peony 10g, dried immature fruit of citron orange 10g, herba lysimachiae 15 g, Hai Jin of the present invention Sand 15 g, 10 g of Radix Curcumae, Radix Glycyrrhizae 5 g), convert 500ml warm water, and point once a dose within postprandial 1 hour in the morning, afternoon and evening.It beats after medication every time 10 minutes, frequency 120 times per minute or so, urine situation was observed when patient per being advised to urinate, is ached when assessing renal colic The degree of pain, duration are discharged or treat 2 weeks with calculus as cut-off point of observation.

4, observation index

4.1 clinical symptoms (pain, blood urine, urinary tract infections, urinary obstruction) variation, urinary system B ultrasound change (calculus shade, calculus Position, calculus quantity, ponding).

4.2 assess renal colic pain degree using pain visual imitation assessment method (VAS), record each panic attacks and alleviate Time, record 2 weeks in panic attacks number.

4.3 Chinese medicine syndrome integrals (pain in the loins, difficulty and pain in micturition, spiritlessness and weakness, aversion to cold and cold limbs, hematuria,

5, criterion of therapeutical effect

Recovery from illness: calculus is all discharged, and symptom disappears, and check urinary system B is super to show that calculus shade disappears；It is effective: calculus part row Out, symptom improves, though check urinary system B is super to show that stone location moves down, diminution or fragmentation dissolution or calculus are without movement, kidney The substantially reduced or concurrent urinary infection of ponding symptom is controlled or substantially reduced；It is invalid: symptom and sign without improvement, Urinary system B superjunction stone is unchanged, and secondary infection, obstruction, ponding still have, or even aggravates.

6, treatment results:

6.1 row's stone quantity and sizes: 2 weeks check B ultrasound of observation show that calculus shadow disappears 35 altogether, shifts 16, motionless 27.Directly Meet 16, calculus for finding discharge, maximum gauge 0.8cm, minimum 0.2cm；The more ovum circulars of shape or more prismatics.Lithagogue rate reaches within 2 weeks 44.87%。

6.2 clinical efficacies: recovery from illness 16, effective 29, clinical total effectively example 100%.

6.3 pain

The degree of pain scores assessment renal colic during row's stone, as the result is shown: medical 18 patients of acute renal colic control Renal colic pain degree be averaged VAS scoring as 8.25 ± 3.18 points before treating, and duration of medication 2 weeks interior to occur renal colic frequency repeatedly and be total to Meter 26 times (containing commonly medical patient), each attack degree is in lower average tendency, pain degree be averaged VAS scoring be 4.65 ± 1.85.This treatment can reduce the scoring of renal colic pain during row's stone, prompt to play the role of alleviating renal colic.

7, conclusion

The present invention plays the effect of Chinese prescription " promoting qi circulation and relieving pain, treating stranguria remove stone ", wherein bavin under the guidance of Basic Theories of Chinese Medicine The defeated turn of few yang-energy machine of yin of fainting recklessly, promoting qi circulation and relieving pain；Endothelium corneum gigeriae galli is treating stranguria fossil, Radix Curcumae relieve stagnation promoting the circulation of qi, promoting blood circulation and stopping pain；Chinese herbaceous peony matches glycyrrhizic acid Sweetization yin, relieving spasm to stop pain；Herba lysimachiae, Lygodium japonicum clearing heat and promoting diuresis.Group can stop bitterly stone and go out.As it can be seen that the present invention can be safe and effective Alleviate the exclusion that stone in urinary system renal colic promotes calculus, medicine source source is sufficient, cheap, economy side's example, secondary without any poison Effect, is worthy of popularization.

Typical case:

Field so-and-so, male, 60 years old, Han nationality was married, Qujing of Yunnan people, go to a doctor April 8 2019 date.Patient previously has glycosuria The medical histories such as disease, rheumatic heart disease, coronary heart disease, hyperuricemia, gout, renal insufficiency, complex renal calculus.This time because on the left of paroxysm Pain in the loins, blood urine, it is vexed, limb cold 1 day it is medical, pale tongue folder is green, and tongue fur is thin white, the thin chord number of arteries and veins.B ultrasound shows double kidney Calculus acoustic images (the left sinus renalis area opaque dark area of fluid 3.9 × 1.3cm, 0.5 × 0.3cm of small cup on right kidney, 3 calculus shadows of left kidney, maximum 1 in upper small cup 0.8 × 0.6cm, 1 0.4 × 0.4cm of inferior calyx, left ureter upper section moderate ponding, left side distal ureteral calculi may.Routine urinalysis Urine proteins 2+, occult blood 3+, arena red blood cell.Take prescription of the present invention (radix bupleuri 10g, endothelium corneum gigeriae galli 10g, Chinese herbaceous peony 15g, the dried immature fruit of citron orange 10g, 15 g of herba lysimachiae, 15 g of Lygodium japonicum, 15 g of Radix Curcumae, Radix Glycyrrhizae 5 g) exclude 3 burl stones for 20 days altogether, 0.8 × 0.6cm, 0.6 × 0.5cm, 0.3 × 0.3cm, the double kidneys of check B ultrasound also respectively have 1, left 0.4 × 0.4cm of lower calyx, 0.5 × 0.3cm of small cup on right kidney, For bilateral ureteral without ponding, bladder is without exception.It arranges stone and occurs 3 left side lumbars and inferior belly gas pain altogether in the process, degree is not violent, Continue 10-30 minutes every time, adhere to taking traditional Chinese medicine, stops stone after appropriate activity bitterly and go out.

What certain, male, 42 years old, Han nationality was married, Kunming, Yunnan people, went to a doctor October 8 2018 date.Patient previously has kidney The medical histories such as calculus 5 years, B ultrasound prompted right renal pelvis radiopaque calculus shadow 1 × 0.8cm of diameter when going to a doctor, and occasionally has the soreness of waist, special not without other Suitable, pink tongue, tongue fur is thin white, wiry and frequent pulse.Urinalysis is without exception.Take prescription of the present invention (radix bupleuri 10g, endothelium corneum gigeriae galli 10g, Chinese herbaceous peony 10g, dried immature fruit of citron orange 10g, 10 g of Radix Curcumae, Radix Glycyrrhizae 5 g) arranges stone, and 3 left lumbars of appearance and inferior belly gas pain, degree be not acute altogether in the process Strong, 7 days heel row remove 1 × 0.7cm of calculus diameter, and check B ultrasound kidney stone shadow disappears.

Claims

1. renal colic caused by a kind of alleviation nephrolith disease and the Chinese medicine composition for promoting calculus discharge, it is characterised in that the Chinese medicine Composition by weight ratio, including 5 ~ 20 parts of radix bupleuri, 5 ~ 20 parts of endothelium corneum gigeriae galli, 5 ~ 20 parts of Chinese herbaceous peony, 5 ~ 20 parts of the dried immature fruit of citron orange.

2. renal colic caused by alleviation nephrolith disease according to claim 1 and the Chinese medicine composition for promoting calculus discharge, special Sign is to include 8 ~ 15 parts of radix bupleuri, 8 ~ 15 parts of endothelium corneum gigeriae galli, 8 ~ 15 parts of Chinese herbaceous peony, 8 ~ 15 parts of the dried immature fruit of citron orange in the Chinese medicine composition.

3. renal colic caused by alleviation nephrolith disease according to claim 1 and the Chinese medicine composition for promoting calculus discharge, special Sign is to include 9 ~ 12 parts of radix bupleuri, 9 ~ 12 parts of endothelium corneum gigeriae galli, 9 ~ 12 parts of Chinese herbaceous peony, 9 ~ 12 parts of the dried immature fruit of citron orange in the Chinese medicine composition.

4. renal colic caused by alleviation nephrolith disease according to claim 1,2 or 3 and the Chinese medicine composition for promoting calculus discharge, It is characterized in that in the Chinese medicine composition also containing 8 ~ 15 parts of herba lysimachiae, 5 ~ 15 parts of Lygodium japonicum, 5 ~ 15 parts of Radix Curcumae or Radix Glycyrrhizae 5 ~ One of 10 parts or more than one.

5. renal colic caused by alleviation nephrolith disease according to claim 4 and the Chinese medicine composition for promoting calculus discharge, special Sign is in the Chinese medicine composition also containing in 8 ~ 15 parts of herba lysimachiae, 8 ~ 12 parts of Lygodium japonicum, 8 ~ 12 parts of Radix Curcumae or 6 ~ 8 parts of Radix Glycyrrhizae One or more.

6. a kind of dosage form of Chinese medicine composition preparation described in any one according to claim 1 ~ 5, it is characterised in that the Chinese medicine Composition except can decocting cook at decoction in addition to, medically acceptable auxiliary material, which can also be added, can be prepared into tablet, capsule, cream Any one in agent, syrup, granule, pulvis, powder and/or pill.

7. the dosage form of Chinese medicine composition preparation according to claim 6, it is characterised in that the preparation of the syrup: will be described Each prescription is by weight adding 50-70 DEG C of water of 2 ~ 5 times of amounts to be cooked by slow fire 3 times after impregnating 5-30min, and 5 ~ 20min, merges filter every time Liquid, normal temperature and pressure are concentrated into 300 ~ 400ml, and 50 ~ 100g honey, sucrose etc. is added and is prepared into syrup.

8. the dosage form of Chinese medicine composition preparation according to claim 6, it is characterised in that the preparation of the granule: will be described Each prescription is crushed to 60 ~ 100 mesh, by weight 2 ~ 5 times of amount water are added, is cooked by slow fire 2 times, 5 ~ 25min, merging filtrate are filtered every time Liquid is concentrated into 1.21 ~ 1.25(80 DEG C of relative density)；60-70 DEG C is dried under vacuum to constant weight, and dry cream is crushed to 60-80 mesh, by dry Cream powder weight ratio adds 0.6 times of dextrin, and 0.4 times of soluble starch uniformly mixes, and using suitable water as wetting agent, carries out Wet granulation, 60-65 DEG C of drying are prepared into granule after whole grain.

9. the dosage form of Chinese medicine composition preparation according to claim 6, it is characterised in that the preparation of the capsule: will be described Each prescription is crushed to 60 ~ 100 mesh, by weight 2 ~ 5 times of amount water are added, is cooked by slow fire 2 times, 5 ~ 25min, merging filtrate are filtered every time Liquid is concentrated into 1.21 ~ 1.25(80 DEG C of relative density)；60-70 DEG C is dried under vacuum to constant weight, and dry cream is crushed to 60-80 mesh, by dry Cream powder weight ratio adds 0.6 times of dextrin, and 0.4 times of soluble starch uniformly mixes, and using suitable water as wetting agent, carries out Wet granulation, 70-80 DEG C of dry 45-60min cross 20-40 mesh, are packed into No. 0 capsule and are prepared into capsule.

10. the renal colic caused by alleviating nephrolith disease of the Chinese medicine composition described in claim 1 ~ 5 any one simultaneously promotes calculus to arrange Application in out, and/or alleviate renal colic caused by nephrolith disease in preparation and promote the application in the drug of calculus discharge.