CN102293845B

CN102293845B - Gu yan kang

Info

Publication number: CN102293845B
Application number: CN 201110252988
Authority: CN
Inventors: 王赛; 梁丽红
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-08-30
Filing date: 2011-08-30
Publication date: 2013-03-27
Anticipated expiration: 2031-08-30
Also published as: CN102293845A

Abstract

The invention provides a medicine for treating osteomyelitis, namely Gu yan kang. The medicine consists of the following components in percentage by mass: 2.5 to 30 percent of coptis chinensis, 5 to 30 percent of gardenia, 5 to 40 percent of frankincense, 5 to 35 percent of myrrh, and 15 to 50 percent of sophora flavescens. The medicine has the characteristics of high cure rate, short treatment course, high safety, low cost and the like, a patient recovers quickly after taking the medicine, and the relapse rate is low, and the medicine is easy to prepare; and the medicine has the effects of clearing away heat and toxic materials, invigorating the circulation of blood and removing blood stasis, removing necrotic tissue and promoting granulation, relieving pain and diminishing inflammation, strengthening tendons and bones, inducing diuresis and reducing edema, restraining skin and the like.

Description

A kind ofly treat myelitic medicine

Technical field

The present invention relates to a kind of myelitic medicine---Gu yan kang for the treatment of, especially a kind ofly treat myelitic external used medicine, belong to the biologic product technology field.

Background technology

Osteomyelitis belongs to commonly encountered diseases, obstinate disease, and in recent years along with the change of growth in the living standard and the environment of seeking medical advice, sickness rate obviously descends before than more than ten years, but also has certain morbidity quantity.Rural area, city and various age all can occur, as treat the untimely limbs part consumption body constitution of suppurating for a long time that causes, bone, joint deformity dysfunction, reason characteristic of disease fracture, bone does not connect or disable all the life, even the severe complication such as canceration threat to life.For a long time, treat myelitic method both at home and abroad and be: 1, Traditional Chinese Medicine therapy: a, oral Chinese herbal medicine, mainly take activating blood circulation to dissipate blood stasis, heat-clearing and toxic substances removing as main.Upper red medicine in the b, local sinus tract, make sequestrum in its medullary cavity, edema granulation and around downright bad soft tissue slowly rot to treat its discharge, like this course for the treatment of quite long, even be difficult to all the life healing; 2, western medicine therapy: partial cut drain, medullary cavity decompression and focal cleaning.A, in acute stage, local redness, pain, heating, fervescence carries out incision and drainage and can discharge pus, congestion and swelling pain alleviates, the temperature decline state of an illness can temporarily be alleviated.B, osteomyelitis can be carried out pulp cavity and be turned the hole during acute stage, thereby the pressure in the reduction pulp cavity, can ease the pain and swelling, but pus can not get abundant drain in the pulp cavity, and along with passage of time, cortical bone thickens, pulp cavity constriction sequestrum forms, Chronic Sinus is suppurated for a long time, does not prolongedly heal, and forms chronic suppurative osteomyelisis.C, clearance of focal lesion, through the through sclerotin of skin otch, at first remove perilesional pus and downright bad soft tissue, then deep windowing enters pulp cavity, thoroughly remove the sequestrum granulation pus pathological tissues in the pulp cavity, oily yarn filling bone wound surface after the flushing, pressure dressing wound, the second day after operation sliver of bringing into use Gu yan kang to soak of changing dressings carries out the filling of bone wound surface, once a day.

Summary of the invention

The object of the present invention is to provide a kind of cure rate height, short treating period, recovery is fast, relapse rate is low, safe, cost is low and easy and simple to handle, can treat the external used medicine of acute and chronic, suppurative osteomyelitis.

The present invention realizes by following technical proposal: a kind ofly treat myelitic medicine, it is characterized in that being comprised of the component of following mass percent:

Rhizoma Coptidis 2.5～30 %

Fructus Gardeniae 5～30 %

Olibanum 5～40 %

Myrrha 5～35 %

Radix Sophorae Flavescentis 15～50 %.

Wherein, Rhizoma Coptidis: nature and flavor: (root) hardship, cold, nontoxic; GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Cure mainly heat clearing and damp drying, eliminating fire and detoxication.Fructus Gardeniae: GUIXIN warp; Liver Channel; Lung meridian; The stomach warp; Tri-jiao channel.Cure mainly: calentura is vexed; The liver-fire conjunctival congestion; Headache; Damp and hot yellow infantile malnutrition; Stranguria; The dysentery hematuria; Aphtha of the mouth and tongue; Sore swollen toxin; Sprain and swell and ache.Olibanum: property is hot, bitter, warm; Enter the heart, liver, spleen channel.Cure mainly invigorate blood circulation, circulation of qi promoting, pain relieving.Myrrha: property is bitter, and suffering is flat; Enter liver, spleen, the heart, kidney channel.Cure mainly breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.The effects such as promoting blood circulation and stopping pain, detumescence and promoting granulation are arranged.Radix Sophorae Flavescentis: bitter in the mouth, cold in nature; Return liver, kidney, stomach, large intestine channel.Cure mainly: heat clearing and damp drying, parasite killing, diuresis.

The invention provides the pharmacological action of medicine: the Rhizoma Coptidis of choosing mainly plays heat-clearing and toxic substances removing in prescription, the effect of closing up and holding back skin; Fructus Gardeniae also plays inducing diuresis and reducing edema effect except heat-clearing and toxic substances removing; Olibanum, Myrrha play blood circulation promoting and blood stasis dispelling in prescription, reducing swelling and alleviating pain, the effect of removing the necrotic tissue and promoting granulation; Radix Sophorae Flavescentis is active for detumescence, except the wind damp eliminating, and the function that sheath is antipruritic.Each composition of the present invention is national Chinese crude drug company commercially available prod.

The myelitic medicine for the treatment of of the present invention makes through following method:

Press following mass percent feeding:

Rhizoma Coptidis 2.5～30 %

Fructus Gardeniae 5～30 %

Olibanum 5～40 %

Myrrha 5～35 %

Radix Sophorae Flavescentis 15～50 %;

In the crude drug of steps A, add water to and do not have medicine, be heated to boiling after, continuous heating is 40～60 minutes again, filters to get medicinal liquid and medicinal residues, and medicinal liquid behind conventional autoclave sterilization, is namely got the myelitic medicine for the treatment of.

During use, the sliver of will sterilizing is put into above-mentioned gained and is treated myelitic drug solution immersion after 10 minutes, and the medicine sliver is inserted in the medullary cavity.

The effect that the present invention possesses and advantage: this medicine has heat-clearing and toxic substances removing, activating blood circulation to dissipate blood stasis, removing the necrotic tissue and promoting granulation, analgesic antiphlogistic, bone and muscle strengthening, inducing diuresis and reducing edema, the effects such as convergence skin are applicable to the acute or chronic osteomyelitis that a variety of causes causes, and also can be used for other pyogenic infection and chronic ulcer.Have cure rate height, short treating period, recovery is fast, relapse rate is low, safe, cost is low and the advantage such as easy and simple to handle.

The specific embodiment

Further illustrate content of the present invention below in conjunction with embodiment, but protection scope of the present invention is not limited in these embodiment.

Embodiment 1

Get Rhizoma Coptidis 100g, Fructus Gardeniae 300g, Olibanum 200g, Myrrha 250g, Radix Sophorae Flavescentis 150g; Add water in this 1000g medicine and do not have medicine (being 4000mL), be heated to after the boiling continuous heating 40 minutes again, filter to isolate afterwards medicinal liquid and medicinal residues, behind conventional autoclave sterilization, it is for subsequent use to treat myelitic medicine with medicinal liquid.

Embodiment 2

Get Rhizoma Coptidis 300g, Fructus Gardeniae 50g, Olibanum 400g, Myrrha 100g, Radix Sophorae Flavescentis 150g; Add water in this 1000g medicine and do not have medicine (4000mL), be heated to after the boiling continuous heating 60 minutes again, filter to isolate afterwards medicinal liquid and medicinal residues, behind conventional autoclave sterilization, it is for subsequent use to treat myelitic medicine with medicinal liquid.

Embodiment 3

Get Rhizoma Coptidis 50g, Fructus Gardeniae 300g, Olibanum 50g, Myrrha 350g, Radix Sophorae Flavescentis 250g; Add water in this 1000g medicine and do not have medicine (4000mL), be heated to after the boiling continuous heating 50 minutes again, filter to isolate afterwards medicinal liquid and medicinal residues, behind conventional autoclave sterilization, it is for subsequent use to treat myelitic medicine with medicinal liquid.

Embodiment 4

Get Rhizoma Coptidis 25g, Fructus Gardeniae 150g, Olibanum 255g, Myrrha 150g, Radix Sophorae Flavescentis 420g; In this 1000g medicine, add water 4000mL(and do not have medicine), be heated to after the boiling again continuous heating 45 minutes, filter to isolate afterwards medicinal liquid and medicinal residues, behind conventional autoclave sterilization, it is for subsequent use to treat myelitic medicine with medicinal liquid.

Embodiment 5

Get Rhizoma Coptidis 200g, Fructus Gardeniae 100g, Olibanum 150g, Myrrha 50g, Radix Sophorae Flavescentis 500g; In this 1000g medicine, add water 4000mL(and do not have medicine), be heated to after the boiling again continuous heating 55 minutes, filter to isolate afterwards medicinal liquid and medicinal residues, behind conventional autoclave sterilization, it is for subsequent use to treat myelitic medicine with medicinal liquid.

In order to clearly demonstrate effect of the present invention, the below is as follows with the clinical practice briefing:

1, physical data

In 182 routine patients, male's 130 examples account for 71%; The women is 52 examples, accounts for 29%.Distinguish by myelitic disease sites: lower limb account for 126 examples, and upper limb accounts for 48 examples, and other position accounts for 8 examples (comprising 3 routine internal fixation postoperative infection osteomyelitis), and above-mentioned patient is divided into matched group and treatment group at random, and two groups of patients' ordinary circumstance sees table 1 for details.

2, Therapeutic Method

The matched group postoperative is taken conventional bone dragon pharmaceutical capsules, one day three times, a 4-6 grain.

Treatment group adopts the present invention's medicine, and specifically: the sliver of will sterilizing is put into above-described embodiment 2 gained drug solutions and soaked after 10 minutes, and sliver is inserted in the medullary cavity, and change once every day.

Two groups all by 15 days course of therapy, treat altogether three courses for the treatment of.

Stop using other any medicine during the treatment.

3, observational technique

Period in a medicine is observed weekly once, comprises symptom, sign improvement situation, untoward reaction.

Two, curative effect judgment criteria

1, criterion of therapeutical effect

Cure: all symptoms are eliminated, and rear blood circulation is normal, and limb functional recover is normal.

Produce effects: wound healing, rear blood circulation is normal, and limb functional recover also needs the time.

Effectively: pain disappears, and redness disappears, and pus and secretions disappear.

Invalid: asymptomatic elimination.

2, statistical method

Enumeration data adopts X ²The t check is adopted in check, measurement data.

Total effective rate=cure rate+obvious effective rate+effective percentage

Three, result

Therapeutic outcome sees Table 2.

Part healing person tracking is taken out distant and out of sight result and is: rear 2～5 years, take the photograph the sheet demonstration through X-light and CT-, and former damage or deep sclerotin of windowing are obviously grown or have been repaired.

Four, discussion and cognition

1. among the chronic suppurative osteomyelisis patient, have more than 90% from the seek medical advice between twenty and fifty peasant of difficulty of mountain area shortage of medical services and medicines,, treated timely and effectively and extend for chronicly because the impact of many factors in acute stage, cause the serious consequence of varying degree.Suppurate for a long time such as Chronic Sinus, joint stiffness, body constitution is become thin even is disabled, cancerates etc.

2. treatment: traditional treatment acute-chronic purulent osteomyelitis mostly is greatly simple traditional Chinese medical science non-operative treatment or doctor trained in Western medicine operative treatment.Namely the person takes operative treatment mostly to there being the operative indication, implements medullary cavity decompression and the deep focal cleaning of windowing, and postoperative adopts gentamycin salt sliver to change dressings once every day, even front ten days of postoperative, more because of local transudate, change dressings 2～3 times so need every day, use simultaneously a large amount of antibiotic; The method that adopts the Chinese medicine non-operative treatment is also arranged, namely take spleen-invigorating and kidney-strengthening, solid and gas nutrient blood, activating blood circulation to dissipate blood stasis, heat-clearing and toxic substances removing, promoting of the circulation of QI and removing the obstruction in the collaterals is mended the Chinese medicines such as bone benefit marrow, but all undesirable aspect the course for the treatment of, cure rate, and relapse rate is also higher.And we adopt combination therapy of Chinese and western osteomyelitis, namely use the medicine sliver of this invention after doing focal cleaning thoroughly, and obviously shorten the course for the treatment of, and cure rate improves, and relapse rate reduces.

3. chronic osteomyelitis is if any the sequestrum former, under deep prerequisite of windowing, must thoroughly remove sequestrum, granulation, pus in the pulp cavity, and the sick osseous tissue of excision pulp cavity periphery of inner wall certain depth, use so after surgery medicine of the present invention, the side can accelerate the growth of new bone and the healing of wound, receives more good effect.

Through X ²Check, two groups of ages, sex, state of an illness all have comparability (p〉0.05)

Claims

1. treat myelitic medicine for one kind, it is characterized in that being made by the raw material components of following mass percent:

Rhizoma Coptidis 2.5～30 %

Fructus Gardeniae 5～30 %

Olibanum 5～40 %

Myrrha 5～35 %

Radix Sophorae Flavescentis 15～50 %.