CN106728835A - A kind of Chinese medicine for treating diabetes - Google Patents

A kind of Chinese medicine for treating diabetes Download PDF

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Publication number
CN106728835A
CN106728835A CN201611226204.2A CN201611226204A CN106728835A CN 106728835 A CN106728835 A CN 106728835A CN 201611226204 A CN201611226204 A CN 201611226204A CN 106728835 A CN106728835 A CN 106728835A
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grams
chinese
root
safflower
chinese medicine
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CN106728835B (en
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韩立涛
陈圣杰
徐玉茵
邢彦君
李凤光
高宝琴
石沛龙
常聪
郭红娟
杨亚彬
刘帅超
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Henan Yadu Industrial Co Ltd
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Henan Yadu Industrial Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/57Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/618Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/344Codonopsis
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • A61K36/428Trichosanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488Pueraria (kudzu)
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/79Schisandraceae (Schisandra family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/808Scrophularia (figwort)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964Anemarrhena
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968Ophiopogon (Lilyturf)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
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    • A61K2236/30Extraction of the material
    • A61K2236/37Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

Chinese medicine of diabetes and preparation method thereof is treated the invention discloses a kind of, the Chinese medicine is by weight meter:5 15 grams of the red sage root, 3 10 grams of safflower, the dried rhizome of rehmannia, each 15 25 grams of Chinese yam;Each 5 15 grams of the fruit of Chinese magnoliavine, the root of kudzu vine;Each 10 15 grams of clam meal, bryozoatum;10 20 grams of root of Chinese trichosanthes, 37 grams of the membrane of a chicken's gizzard, watermelon peel, each 10 20 grams of waxgourd peel, 50 70 grams of mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, each 5 15 grams of Radix Codonopsis, 10 15 grams of compositions of 25 35 grams of gypsum and radix scrophulariae.The present invention makes full use of Chinese prescription theoretical, acted in concert with each other between medicine, promoting blood circulation and removing blood stasis, kidney water rises internal heat drop, and the division of labor is clear and definite, primary and secondary is protruded, complement each other and accompanying symptoms is taken into account while main symptom is treated, treatment is comprehensive, determined curative effect, by clinical verification effect is significant, can with long-term taking to diabetes and by caused by diabetes other uncomfortable have significant curative effect.

Description

A kind of Chinese medicine for treating diabetes
Technical field
The present invention relates to technical field of traditional Chinese medicines, particularly a kind of Chinese medicine for treating diabetes.
Background technology
Diabetes are one group of being characterized with hyperglycaemia caused by defect of insulin secretion and/or insulin action obstacle Metabolic disease.Persistent high blood sugar and long-term metabolic disorder etc. can cause body tissue's organ, particularly eye, kidney, angiocarpy And the infringement and its dysfunction and exhaustion of nervous system.Severe patient can cause dehydration, electrolyte disturbance and acid-base imbalance Deng acute complicationses DKA and Hyperosmotic coma.
Oral drugs are mainly used in treating DM2, and for DM2 patient, itself pancreas function has been damaged, and medicine is again Stimulate B cell excreting insulin into pancreatic cell, so work overloadingly, can only accelerate the exhaustion of B cells of pancreas, finally lead Cause drug therapy failure.Additionally, Drug absorbability also prevents the suction of nutriment while intestinal wall prevents glucose absorption Receive, this will result directly in patient's malnutrition, immunity of organisms and declines, and be more easy to concurrent Other diseases.Because oral drugs can only The postprandial blood sugar of DM2 is controlled, the glycemic control to other periods does not have effect completely, it is impossible to by the control of the hours blood glucose of whole day 24 Steadily, so the generation of complication can not be prevented or delayed.Hair style DM2 patient at the beginning of especially, if initially selecting mouth Drug therapy is taken, not only glycemic control is bad, also lose optimal therapic opportunity.Most of this kind of DM2 patient takes for a long time During medicine, not only the disease of itself is not effectively controlled, and also results in liver and kidney is irreversibly injured, and then suffers from Disease soon, the life that they cannot be as normal person.
The drawbacks of MSI insulin therapy, daily 2-5 timing carries out hypodermic injection, it is impossible to fully meet DM The physiological requirements of patient itself, it is impossible to deal with uncertain insulin requirements amount, unplanned events can not also be handled a situation with ease; After with a large amount of insulin of a shot, in subcutaneous easy formation " washing basin ", it is non-constant that absorption of insulin enters blood speed, causes blood The larger fluctuation of sugar, it is impossible to which the control of the hours blood glucose of whole day 24 is steady;(3) can not block or reduce the constant absorption of insulin, Once generation hypoglycemia, just must additionally take food, unfavorable to glycemic control;Hypoglycemic speed is slower, and insulin dosage is big, easily sends out The outer hypoglycemia of business;Injection daily, patient is very painful, also very inconvenient, can not improve the quality of living.
China's medical science is early in B.C. twoth century《The Yellow Emperor's Canon of Internal Medicine》With regard to discussion " category " the diabetes category about diabetes, disappear The meaning of thirsty sick polydipsia of becoming thin.The pathogenesis of diabete, scorching as main pathogenesis with the deficiency of Yin, the deficiency of Yin is this, and scorching is mark, two Person's reciprocal causation, in whole pathological process.
Eastern Han Dynasty's last years of a dynasty or reign, famous traditional Chinese medical science scholar Zhang Zhongjing writes《Synopsis Golden Chamber》One book neutrality is quenched one's thirst a special piece, it is proposed that stomach energy, kidney Empty, lung stomach Tianjin wound is the etiology and pathogenesis of diabete.
Song dynasty Zhao Ji writes《General Records of Holy Universal Relief》There is saying for " three disappearing " the middle beginning, proposes diabete:" it is former its then one, push away it and indicate Three:One says and quenches one's thirst, and with thirsty and unfavorable, draws for drink is exaggerated it;During two say and disappear, sharp with not thirsty, disappear speech in hot gas;Three say kidney Disappear, the multiple profit with thirsty, kidney is dry can not to be made to be brief, and this does not heal long, can be the disease of oedema ulcer ".
Jin and Yuan dynasty ZHU Dan-xi explicitly points out three and disappears for referring to position." above do not disappear person, the person of disappearing in lung ..., stomach ... under the person of disappearing, kidney ... " treatment of emphasizing to quench one's thirst should be based on " yin-nourishing, fall fire, green blood ", wound drinks nourishing Yin and promoting production of body fluid with lotus root juice Treatment is quenched one's thirst.
Liu's interchannel《Three disappear opinion》Cloud:" therefore the person of quenching one's thirst is controlled, the void of kidney tonifying water cold sensation of the genitalia, and purge the sthenic heart-fire sun heat is real, except stomach is dry Heat very, body fluid declines in Ji body, road is dissipated without knot, and without withered, without puckery, then sick day has been for qi and blood profit for body fluid life.”
《Medicine Comprehended three=disappear a piece》Point out:" control the person of disappearing, Yi Run its lung, and clear its stomach, two winter soup masters it;In controlling The person of disappearing, preferably clear its stomach, and grow its kidney, dried rhizome of rehmannia decoction of Eight Ingredients master it;The person of disappearing is controled the inferior, its kidney is preferably grown, and mends its lung, Dihuang Decoction, raw arteries and veins Dissipate and lead it.Disappear clearing stomach person on husband, stomach fire is hindered lung;In disappear nourshing kidney person, phase fire is attacked stomach;Under disappear clearing lung-heat Person, source is with unboiled water in taste.Three disappear control, it is not necessary to specially hold this warp, and grow its change source, then disease easily fully recover from an illness.”
Diabetes spp " is quenched one's thirst " category in the traditional Chinese medical science, more than ancient Chinese medicine doctor more than disappear, in disappear, under disappear " three disappear " argument, controlled by it Method, above disappear clearing away the lungheat and moisturizing, in disappear eliminating stomach-fire, under disappear nourshing kidney fall fire, example is well-established law.Zhao Xianke《Thorough Knowledge of Medicine》Middle promotion " is controlled and disappears it Method, without a point upper, middle and lower, controls kidney for suddenly in the ban ", oppose that abuse bitter cold gram is cut down.
The content of the invention
Long-term taking medicine is needed for existing western medical treatment diabetes, and blood sugar is easy repeatedly, treats halfway problem, It is an object of the invention to provide a kind of Chinese medicine preparation for treating diabetes, to quench one's thirst as basic, diabetes are effectively treated.
The technical scheme that the present invention solves above-mentioned technical problem is,
A kind of Chinese medicine for treating diabetes, by weight meter:5-15 grams of the red sage root, 3-10 grams of safflower, the dried rhizome of rehmannia, each 15- of Chinese yam 25 grams;Each 5-15 grams of the fruit of Chinese magnoliavine, the root of kudzu vine;Each 10-15 grams of clam meal, bryozoatum;10-20 grams of root of Chinese trichosanthes, 3-7 grams of the membrane of a chicken's gizzard, watermelon Each 10-20 grams of skin, waxgourd peel, 50-70 grams of mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, each 5-15 grams of Radix Codonopsis, 25-35 grams of gypsum and radix scrophulariae 10-15 grams of composition.
Preferably, a kind of Chinese medicine for treating diabetes, by weight meter:8-10 grams of the red sage root, 5-8 grams of safflower, the dried rhizome of rehmannia, Chinese yam Each 18-22 grams;Each 8-12 grams of the fruit of Chinese magnoliavine, the root of kudzu vine;Each 12-14 grams of clam meal, bryozoatum;13-18 grams of root of Chinese trichosanthes, 4-6 grams of the membrane of a chicken's gizzard, Each 12-18 grams of watermelon peel, waxgourd peel, 55-65 grams of mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, each 8-12 grams of Radix Codonopsis, 28-32 grams of gypsum and unit 12-14 grams of composition of ginseng.
Preferably, a kind of Chinese medicine for treating diabetes, by weight meter:10 grams of the red sage root, 6 grams of safflower, the dried rhizome of rehmannia, Chinese yam each 20 Gram;Each 10 grams of the fruit of Chinese magnoliavine, the root of kudzu vine;Each 12 grams of clam meal, bryozoatum;15 grams of root of Chinese trichosanthes, 5 grams of the membrane of a chicken's gizzard, watermelon peel, waxgourd peel each 15 Gram, 60 grams of mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, each 10 grams of Radix Codonopsis, 12 grams of compositions of 30 grams of gypsum and radix scrophulariae.
In said components,
Safflower
The logical stasis of blood class Chinese medicine of promoting blood circulation
Meridian distribution of property and flavor:Pungent, temperature.The thoughts of returning home, Liver Channel.
Effect:It is promoting blood circulation and removing blood stasis, stimulate the menstrual flow.
Cure mainly:For amenorrhea due to stagnation of blood, postpartum stasis , Disorder lumps in the abdomen stagnate, injuries from falls as well, measles without adequate eruption.
The red sage root
Blood circulation promoting nourishes blood class Chinese medicine
Meridian distribution of property and flavor:Hardship, is slightly cold.The thoughts of returning home, pericardium, Liver Channel.
Effect:Promoting blood circulation, cool blood to disappear carbuncle, nourishing blood and tranquilization.
Cure mainly:For irregular menstruation, trusted subordinate's pain , lumps in the chest and abdomen, beriberoid pyretic arthralgia, sore swell and ache curative, agitation is insomnia, palpitaition, Insomnia.
Radix rehmanniae recen
Clearing heat and cooling blood class Chinese medicine
Meridian distribution of property and flavor:Sweet, hardship, trembles with fear.The thoughts of returning home, liver and kidney channel.
Effect:Clearing heat and cooling blood, nourishing Yin and promoting production of body fluid.
Cure mainly:For Vexed, tongue is deep red, blood-head tells nosebleed, atropurpureus macula, consumption of YIN caused by febrile disease, many drinks of quenching one's thirst.
Chinese yam
Tonifying Qi class Chinese medicine
Meridian distribution of property and flavor:It is sweet, put down.Returns spleen, lung, kidney channel.
Effect:Supplementing qi and nourishing yin, help spleen and lung, invigorates the kidney and stops nocturnal emission.
Cure mainly:For spleen eating less, diarrhea with loose stool, deficiency syndrome of the lung cough and asthma, frequent micturition of passing out semen, the deficiency of Yin is quenched one's thirst.
The fruit of Chinese magnoliavine
Astringentses Chinese medicine
Meridian distribution of property and flavor:Acid, temperature.Return lung, kidney, the heart channel of Hang-Shaoyin.
Effect:Astringe the lung nourshing kidney, promote the production of body fluid arrest sweating, puckery smart antidiarrheal, antitoxic heart-soothing and sedative.
Cure mainly:For chronic cough and dyspnea of deficiency type, injury thirst, spontaneous sweating, emission due to the kidney deficiency, spleen kidney deficiency is rushed down, palpitation and insomnia.
Root of Chinese trichosanthes
Clear gas purging intense heat class Chinese medicine
Meridian distribution of property and flavor:Bitter, micro-sweet, trembles with fear.Attach to the lung and stomach meridians.
Effect:Clearing heat and promoting fluid, detumescence and apocenosis.
Cure mainly:For pyreticosis Tianjin wound, dry is quenched one's thirst, cough with lung heat, dryness of the lung hemoptysis, heat toxin sore carbuncle.
The tuber of dwarf lilyturf
Tonifying yin class Chinese medicine
Meridian distribution of property and flavor:Sweet, slight bitter, is slightly cold.Return lung, the heart, stomach.
Effect:Yin nourishing and lung moistening, reinforcing stomach reg fluid, relieving restlessness that clears away heart-fire.
Cure mainly:Thick for cough caused by dryness phlegm, labor is coughed spitting of blood, thirsty and dry pharynx, vexed insomnia.
The root of kudzu vine
Relieving the exterior syndrome with drugs pungent in flavor and cool in property class Chinese medicine
Meridian distribution of property and flavor:It is sweet, pungent, it is cool.Attach to the lung and stomach meridians.
Effect:Relieving muscles diaphoresis, promoting eruption, Shengyang Zhixie promotes the production of body fluid to quench thirst.
Cure mainly:For fever caused by exogenous pathogens, stiff nape and back, measles without adequate eruption, damp-heat dysentery, splenasthenic diarrhea, pyreticosis polydipsia is quenched one's thirst Card.
Clam meal
Nature and flavor:Taste is salty;It is cold in nature;
Return through:Lung;Kidney;Liver Channel;
Indication:Heat-clearing;Resolving sputum dampness removing;Softening hard masses.Cure mainly stomachache;Phlegm and retained fluid is breathed with cough;Aqueous vapor edema;Urinary obstruction;Seminal emission; Gonorrhoea;Metrorrhagia;Under band;Carbuncle swells;Goiter and tumor;Scald.
Bryozoatum
Classification:Expectorants, antitussives and anti-asthmatics medicine
Meridian distribution of property and flavor:It is cold;It is salty;Return lung is passed through
Indication:Clearing lung and eliminating phlegm, softening and resolving hard mass.For phlegm-heat cough, the sticky person of phlegm, scrofula, goiter and tumor.
The membrane of a chicken's gizzard
The class that helps digestion Chinese medicine
Meridian distribution of property and flavor:It is sweet, put down.Returns spleen, stomach, small intestine, bladder warp.
Effect:Stomach strengthening and digestion promoting, controlling nocturnal emission with astringent drugs stops something lost.
Cure mainly:For accumulation of food in the stomach and intes tine due to indigestion, infantile malnutrition, enuresis seminal emission, urolithiasis.
Watermelon peel
Clear gas purging intense heat class Chinese medicine
Meridian distribution of property and flavor:It is sweet, light, it is cool in nature.The thoughts of returning home, stomach, bladder warp.Refrigerant solution profit.
Effect:Clear heat relieving restlessness, diuresis of quenching one's thirst.
Cure mainly:Cure mainly hot summer weather polydipsia, oliguresis, oedema, aphthae.
Waxgourd peel
Diuresis detumescence class Chinese medicine
Meridian distribution of property and flavor:It is sweet, it is slightly cold.Return lung, small intestinl channel.
Effect:Inducing diuresis for removing edema.
Cure mainly:For damp and hot oedema.
Mantis egg-case
Astringentses Chinese medicine
Meridian distribution of property and flavor:It is sweet, salty, put down.Return liver and kidney channel.
Effect:Astringent sperm contracting urine, tonifies the kidney and support yang.
Cure mainly:For passing out semen, frequent micturition, the enuresis, impotence.
The wind-weed
Clear gas purging intense heat class Chinese medicine
Meridian distribution of property and flavor:It is bitter, sweet, tremble with fear.Return lung, stomach, kidney channel.
Effect:Clearing heat-fire, nourshing Yin and drynsessmoistening prescription.
Cure mainly:For warm heat disease high fever polydipsia, cough with lung heat, deficiency of Yin dry cough, osteopyrexia and fever, Heat Diabetes.
Radix Codonopsis
Tonifying Qi class Chinese medicine
Meridian distribution of property and flavor:It is sweet, put down.Returns spleen, lung channel.
Effect:Tonifying middle-Jiao and Qi, blood-nourishing of promoting the production of body fluid.
Cure mainly:For the deficiency of qi in middle-jiao, anorexia and loose stool, cough and asthma shortness of breath, injury thirst, blood deficiency chlorosis, palpitation and dizziness.
Gypsum
Clear gas purging intense heat class Chinese medicine
Meridian distribution of property and flavor:It is pungent, sweet, Great Cold.Attach to the lung and stomach meridians.
Effect:Clearing heat-fire, relieving restlessness is quenched the thirst.
Cure mainly:For warm heat disease high fever polydipsia, lung heat cough and asthma, stomach headache due to fire-evil, swelling and aching of gum;Sore is burst long, eczema, is scalded Wound.
Radix scrophulariae
Clearing heat and cooling blood class Chinese medicine
Meridian distribution of property and flavor:It is bitter, sweet, salty, cold.Return lung, stomach, kidney channel.
Effect:Clearing heat and cooling blood, detoxicating and resolving a mass, Yin-nourishing and body fluid promoting.
Cure mainly:Joined the army point for heat, fever aggravated at night, blood-head hair spot, abscess of throat, carbuncle sore tumefacting virus, dry constipation of intestines.
Present invention also offers a kind of preparation method of the Chinese medicine for treating diabetes, comprise the following steps:
1) clam meal, bryozoatum and gypsum are mixed and is decocted, filtering takes supernatant;
2) by the red sage root, the dried rhizome of rehmannia, Chinese yam, the fruit of Chinese magnoliavine, the root of kudzu vine, root of Chinese trichosanthes, watermelon peel, waxgourd peel, mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, Radix Codonopsis and radix scrophulariae are cleaned, and crush and add ethanol water to flow back 30-50 minutes, extract effective ingredient;
3) supercritical CO is loaded after safflower is crushed2Supercritical CO is carried out in extraction kettle2Extraction, the Stress control of extraction exists Extracting pressure 8-12MPa, 40-60 DEG C of extraction temperature is obtained safflower effective ingredients standby;
4) by the membrane of a chicken's gizzard decoct fry, crush, with step 1), step 2) and step 3) obtained by effective ingredient mix, concentrate Into the medicinal extract of 1.3-1.8g/ml;
5) by step 4) gained extract dry, preparation.
Preferably, step 2) ethanol water weight fraction be 65wt-75wt%.
Preferably, step 5) the dry condition be-78-- 60 DEG C freeze-drying 12-20 hours.
Preferably, step 5) preparation, auxiliary material by the medicinal extract and pharmaceutically is mixed, and the formulation includes mouth Take liquid, granule, tablet, pill, powder, capsule, pill and injection.
The beneficial effects of the invention are as follows:
1st, the invention provides the Chinese prescription of the Chinese medicine for treating diabetes, make full use of Chinese prescription theoretical, it is selected Medicine, promoting blood circulation and removing blood stasis, kidney water rises internal heat and drops, and the division of labor is clear and definite, and primary and secondary is protruded, and complementing each other, it is simultaneous to be taken into account while main symptom is treated Card, has fully demonstrated the exquisite Overall View of Chinese prescription, has coordinated to see, and treatment is comprehensive, determined curative effect, aobvious by clinical verification effect Write, Small side effects can be to diabetes and obvious by other uncomfortable effects caused by diabetes with long-term taking.
2nd, present invention also offers a kind of preparation method of the Chinese medicine for treating diabetes, with reference to specific components in Chinese prescription Property, be combined with existing extraction process, both ensured that effective ingredient has dissolution rate higher, residual is few, and can protect Card effective ingredient is not destroyed.
3rd, the Chinese Herbs of the treatment diabetes that the present invention is provided are protruded, and are had no toxic side effect.
Specific embodiment
Embodiment 1
A kind of Chinese medicine for treating diabetes, by weight meter:5 grams of the red sage root, 3 grams of safflower, the dried rhizome of rehmannia, each 15 grams of Chinese yam;The five tastes Son, each 5 grams of the root of kudzu vine;Each 10 grams of clam meal, bryozoatum;10 grams of root of Chinese trichosanthes, 3 grams of the membrane of a chicken's gizzard, watermelon peel, each 10 grams of waxgourd peel, mulberry Piao 50 grams of octopus, the wind-weed, the tuber of dwarf lilyturf, each 5 grams of Radix Codonopsis, 10 grams of compositions of 25 grams of gypsum and radix scrophulariae.
Its preparation method, comprises the following steps:
1) clam meal, bryozoatum and gypsum are mixed and is decocted, filtering takes supernatant;
2) by the red sage root, the dried rhizome of rehmannia, Chinese yam, the fruit of Chinese magnoliavine, the root of kudzu vine, root of Chinese trichosanthes, watermelon peel, waxgourd peel, mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, Radix Codonopsis and radix scrophulariae are cleaned, and crush and add weight fraction to be 65wt% ethanol waters 30 minutes, extract effective ingredient;
3) supercritical CO is loaded after safflower is crushed2Supercritical CO is carried out in extraction kettle2Extraction, the Stress control of extraction exists Extracting pressure 8MPa, 40 DEG C of extraction temperature is obtained safflower effective ingredients standby;
4) by the membrane of a chicken's gizzard decoct fry, crush, with step 1), step 2) and step 3) obtained by effective ingredient mix, concentrate Into the medicinal extract of 1.3g/ml;
5) by step 4) gained medicinal extract -78 DEG C of freeze-dryings 12 hours and auxiliary material pharmaceutically be mixed and made into oral liquid.
Embodiment 2
A kind of Chinese medicine for treating diabetes, by weight meter:15 grams of the red sage root, 10 grams of safflower, the dried rhizome of rehmannia, each 25 grams of Chinese yam;Five Each 15 grams of taste, the root of kudzu vine;Each 15 grams of clam meal, bryozoatum;20 grams of root of Chinese trichosanthes, 7 grams of the membrane of a chicken's gizzard, watermelon peel, each 20 grams of waxgourd peel, mulberry 70 grams of the egg capsule of a mantis, the wind-weed, the tuber of dwarf lilyturf, each 15 grams of Radix Codonopsis, 15 grams of compositions of 35 grams of gypsum and radix scrophulariae.
Its preparation method, comprises the following steps:
1) clam meal, bryozoatum and gypsum are mixed and is decocted, filtering takes supernatant;
2) by the red sage root, the dried rhizome of rehmannia, Chinese yam, the fruit of Chinese magnoliavine, the root of kudzu vine, root of Chinese trichosanthes, watermelon peel, waxgourd peel, mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, Radix Codonopsis and radix scrophulariae are cleaned, and crush and add weight fraction to be 75wt% ethanol waters 50 minutes, extract effective ingredient;
3) supercritical CO is loaded after safflower is crushed2Supercritical CO is carried out in extraction kettle2Extraction, the Stress control of extraction exists Extracting pressure 12MPa, 60 DEG C of extraction temperature is obtained safflower effective ingredients standby;
4) by the membrane of a chicken's gizzard decoct fry, crush, with step 1), step 2) and step 3) obtained by effective ingredient mix, concentrate Into the medicinal extract of 1.8g/ml;
5) by step 4) gained medicinal extract -60 DEG C of freeze-dryings 20 hours and auxiliary material pharmaceutically be mixed and made into granule.
Embodiment 3
A kind of Chinese medicine for treating diabetes, by weight meter:10 grams of the red sage root, 6 grams of safflower, the dried rhizome of rehmannia, each 20 grams of Chinese yam;The five tastes Son, each 10 grams of the root of kudzu vine;Each 12 grams of clam meal, bryozoatum;15 grams of root of Chinese trichosanthes, 5 grams of the membrane of a chicken's gizzard, watermelon peel, each 15 grams of waxgourd peel, mulberry Piao 60 grams of octopus, the wind-weed, the tuber of dwarf lilyturf, each 10 grams of Radix Codonopsis, 12 grams of compositions of 30 grams of gypsum and radix scrophulariae.
Its preparation method, comprises the following steps:
1) clam meal, bryozoatum and gypsum are mixed and is decocted, filtering takes supernatant;
2) by the red sage root, the dried rhizome of rehmannia, Chinese yam, the fruit of Chinese magnoliavine, the root of kudzu vine, root of Chinese trichosanthes, watermelon peel, waxgourd peel, mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, Radix Codonopsis and radix scrophulariae are cleaned, and crush and add weight fraction to be 70wt% ethanol waters 40 minutes, extract effective ingredient;
3) supercritical CO is loaded after safflower is crushed2Supercritical CO is carried out in extraction kettle2Extraction, the Stress control of extraction exists Extracting pressure 10MPa, 500 DEG C of extraction temperature is obtained safflower effective ingredients standby;
4) by the membrane of a chicken's gizzard decoct fry, crush, with step 1), step 2) and step 3) obtained by effective ingredient mix, concentrate Into the medicinal extract of 1.5g/ml;
5) by step 4) gained medicinal extract -70 DEG C of freeze-dryings 18 hours and auxiliary material pharmaceutically be mixed and made into injection.
Embodiment 4
A kind of Chinese medicine for treating diabetes, by weight meter:7 grams of the red sage root, 4 grams of safflower, the dried rhizome of rehmannia, each 17 grams of Chinese yam;The five tastes Son, each 8 grams of the root of kudzu vine;Each 11 grams of clam meal, bryozoatum;13 grams of root of Chinese trichosanthes, 4 grams of the membrane of a chicken's gizzard, watermelon peel, each 13 grams of waxgourd peel, mulberry Piao 55 grams of octopus, the wind-weed, the tuber of dwarf lilyturf, each 7 grams of Radix Codonopsis, 11 grams of compositions of gypsum 28 grams (being decocted first) and radix scrophulariae.
Its preparation method, comprises the following steps:
1) clam meal, bryozoatum and gypsum are mixed and is decocted, filtering takes supernatant;
2) by the red sage root, the dried rhizome of rehmannia, Chinese yam, the fruit of Chinese magnoliavine, the root of kudzu vine, root of Chinese trichosanthes, watermelon peel, waxgourd peel, mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, Radix Codonopsis and radix scrophulariae are cleaned, and crush and add weight fraction to be 68wt% ethanol waters 34 minutes, extract effective ingredient;
3) supercritical CO is loaded after safflower is crushed2Supercritical CO is carried out in extraction kettle2Extraction, the Stress control of extraction exists Extracting pressure 9MPa, 44 DEG C of extraction temperature is obtained safflower effective ingredients standby;
4) by the membrane of a chicken's gizzard decoct fry, crush, with step 1), step 2) and step 3) obtained by effective ingredient mix, concentrate Into the medicinal extract of 1.4g/ml;
5) by step 4) gained medicinal extract -74 DEG C of freeze-dryings 16 hours and auxiliary material pharmaceutically be mixed and made into tablet.
Embodiment 5
A kind of Chinese medicine for treating diabetes, by weight meter:9 grams of the red sage root, 7 grams of safflower, the dried rhizome of rehmannia, each 19 grams of Chinese yam;The five tastes Son, each 9 grams of the root of kudzu vine;Each 13 grams of clam meal, bryozoatum;13 grams of root of Chinese trichosanthes, 6 grams of the membrane of a chicken's gizzard, watermelon peel, each 13 grams of waxgourd peel, mulberry Piao 65 grams of octopus, the wind-weed, the tuber of dwarf lilyturf, each 13 grams of Radix Codonopsis, 13 grams of compositions of 32 grams of gypsum and radix scrophulariae.
Its preparation method, comprises the following steps:
1) clam meal, bryozoatum and gypsum are mixed and is decocted, filtering takes supernatant;
2) by the red sage root, the dried rhizome of rehmannia, Chinese yam, the fruit of Chinese magnoliavine, the root of kudzu vine, root of Chinese trichosanthes, watermelon peel, waxgourd peel, mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, Radix Codonopsis and radix scrophulariae are cleaned, and crush and add weight fraction to be 71wt% ethanol waters 38 minutes, extract effective ingredient;
3) supercritical CO is loaded after safflower is crushed2Supercritical CO is carried out in extraction kettle2Extraction, the Stress control of extraction exists Extracting pressure 11MPa, 48 DEG C of extraction temperature is obtained safflower effective ingredients standby;
4) by the membrane of a chicken's gizzard decoct fry, crush, with step 1), step 2) and step 3) obtained by effective ingredient mix, concentrate Into the medicinal extract of 1.6g/ml;
5) by step 4) gained medicinal extract -70 DEG C of freeze-dryings 17 hours and auxiliary material mf mass pil pharmaceutically.
Embodiment 6
A kind of Chinese medicine for treating diabetes, by weight meter:13 grams of the red sage root, 8 grams of safflower, the dried rhizome of rehmannia, each 23 grams of Chinese yam;The five tastes Son, each 13 grams of the root of kudzu vine;Each 14 grams of clam meal, bryozoatum;14 grams of root of Chinese trichosanthes, 4 grams of the membrane of a chicken's gizzard, watermelon peel, each 17 grams of waxgourd peel, mulberry Piao 68 grams of octopus, the wind-weed, the tuber of dwarf lilyturf, each 14 grams of Radix Codonopsis, 14 grams of compositions of gypsum 34 grams (being decocted first) and radix scrophulariae.
Its preparation method, comprises the following steps:
1) clam meal, bryozoatum and gypsum are mixed and is decocted, filtering takes supernatant;
2) by the red sage root, the dried rhizome of rehmannia, Chinese yam, the fruit of Chinese magnoliavine, the root of kudzu vine, root of Chinese trichosanthes, watermelon peel, waxgourd peel, mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, Radix Codonopsis and radix scrophulariae are cleaned, and crush and add weight fraction to be 73wt% ethanol waters 42 minutes, extract effective ingredient;
3) supercritical CO is loaded after safflower is crushed2Supercritical CO is carried out in extraction kettle2Extraction, the Stress control of extraction exists Extracting pressure 9MPa, 52 DEG C of extraction temperature is obtained safflower effective ingredients standby;
4) by the membrane of a chicken's gizzard decoct fry, crush, with step 1), step 2) and step 3) obtained by effective ingredient mix, concentrate Into the medicinal extract of 1.4g/ml;
5) by step 4) gained medicinal extract -68 DEG C of freeze-dryings 18 hours and auxiliary material mf mass pil pharmaceutically.
Embodiment 7
A kind of Chinese medicine for treating diabetes, by weight meter:14 grams of the red sage root, 4 grams of safflower, the dried rhizome of rehmannia, each 16 grams of Chinese yam;The five tastes Son, each 6 grams of the root of kudzu vine;Each 11 grams of clam meal, bryozoatum;11 grams of root of Chinese trichosanthes, 4 grams of the membrane of a chicken's gizzard, watermelon peel, each 11 grams of waxgourd peel, mulberry Piao 52 grams of octopus, the wind-weed, the tuber of dwarf lilyturf, each 6 grams of Radix Codonopsis, 11 grams of compositions of 28 grams of gypsum and radix scrophulariae.
Its preparation method, comprises the following steps:
1) clam meal, bryozoatum and gypsum are mixed and is decocted, filtering takes supernatant;
2) by the red sage root, the dried rhizome of rehmannia, Chinese yam, the fruit of Chinese magnoliavine, the root of kudzu vine, root of Chinese trichosanthes, watermelon peel, waxgourd peel, mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, Radix Codonopsis and radix scrophulariae are cleaned, and crush and add weight fraction to be 74wt% ethanol waters 48 minutes, extract effective ingredient;
3) supercritical CO is loaded after safflower is crushed2Supercritical CO is carried out in extraction kettle2Extraction, the Stress control of extraction exists Extracting pressure 9MPa, 56 DEG C of extraction temperature is obtained safflower effective ingredients standby;
4) by the membrane of a chicken's gizzard decoct fry, crush, with step 1), step 2) and step 3) obtained by effective ingredient mix, concentrate Into the medicinal extract of 1.5g/ml;
5) by step 4) gained medicinal extract -64 DEG C of freeze-dryings 19 hours and auxiliary material pharmaceutically be mixed and made into powder.
Embodiment 8
A kind of Chinese medicine for treating diabetes, by weight meter:8 grams of the red sage root, 6 grams of safflower, the dried rhizome of rehmannia, each 17 grams of Chinese yam;The five tastes Son, each 13 grams of the root of kudzu vine;Each 13 grams of clam meal, bryozoatum;17 grams of root of Chinese trichosanthes, 6 grams of the membrane of a chicken's gizzard, watermelon peel, each 17 grams of waxgourd peel, mulberry Piao 68 grams of octopus, the wind-weed, the tuber of dwarf lilyturf, each 14 grams of Radix Codonopsis, 14 grams of compositions of 29 grams of gypsum and radix scrophulariae.
Its preparation method, comprises the following steps:
1) clam meal, bryozoatum and gypsum are mixed and is decocted, filtering takes supernatant;
2) by the red sage root, the dried rhizome of rehmannia, Chinese yam, the fruit of Chinese magnoliavine, the root of kudzu vine, root of Chinese trichosanthes, watermelon peel, waxgourd peel, mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, Radix Codonopsis and radix scrophulariae are cleaned, and crush and add weight fraction to be 65wt ethanol waters 49 minutes, extract effective ingredient;
3) supercritical CO is loaded after safflower is crushed2Supercritical CO is carried out in extraction kettle2Extraction, the Stress control of extraction exists Extracting pressure 12MPa, 58 DEG C of extraction temperature is obtained safflower effective ingredients standby;
4) by the membrane of a chicken's gizzard decoct fry, crush, with step 1), step 2) and step 3) obtained by effective ingredient mix, concentrate Into the medicinal extract of 1.7g/ml;
5) by step 4) -62 DEG C of medicinal extract of gained freeze-drying 12-20 hours and auxiliary material pharmaceutically be mixed and made into dripping pill Agent.
Comparative example 1:The addition of the mantis egg-case in embodiment 3 is become 30 grams, other are constant.
Comparative example 2:Mantis egg-case in embodiment 3 is replaced with cuttlebone, other are constant.
We's cube is at all:One is homogeny of clear fluid and blood, is grown each other, and deficiency of YIN-blood, sering is not filled;Two be it is scorching can Disappear bright body fluid, consumes impairment of yin blood, and hematogenous blockage, extravasated blood is stagnated, this be " as if blood boat, as if water, water Tianjin is abundant, and boat begins to manage it in Tianjin, If body fluid exhausts to be burnt, blood is retarded by silt for it ";Three is Yin and fluid deficiency, injures yang-energy, agitates powerless, is stopped in extravasated blood;Four is sugar Urine disease is how touching refractory, and long void enters network, and pathogen usually intruding into collateral in protracted disease, qi and blood does not form silt freely, and this is " disease enters depth long, and it is puckery that battalion defends row ".Extravasated blood Interior knot, strongly fragrant longization heat, the bright impairment of yin of heat can then cause or aggravate to quench one's thirst.
Tang Rongchuan exists《Treatise on blood trouble》Middle theory:" extravasated blood is inner i.e. thirsty ... blood and gas is not originally from having extravasated blood inside, therefore gas is not Must be logical, it is impossible to carry the rising of water Tianjin, the extravasated blood that is with thirsty ... goes then not thirsty ".
Silt choke is stagnant, aqueous dysbolism, Tianjin must not cloth, essence of water and grain must not moisten foster internal organs, four limbs bones of the body collectively, instead with Urine and go, send out to quench one's thirst.It is the main pathogenesis of diabetes that the deficiency of Yin is scorching, and extravasated blood and the scorching reciprocal causation of the deficiency of Yin, with The development of the state of an illness, causes yin and yang imbalance, produces many complication.
Extravasated blood is both a paathogenic factor, is again a pathological product, and extravasated blood can both cause diabetes, is also easy to produce again after being ill Extravasated blood, aggravates disease, and easily triggers various complication again.So whole process of the extravasated blood through diabetes.
Prove, promoting blood flow and remove blood stasis drug can improve microcirculation disorder, accelerate microcirculation blood flow velocity, reduce blood viscosity, promote Capillary network is opened to be increased, (parteriole, veinlet, arteriole, micro- to internal different parts (heart and brain kidney etc.) and different type Venous capillary) blood vessel have dilating effect, so as to increase RBF;For the thrombus for having been formed, promoting blood circulationization Silt medicine is then that, by suppressing platelet function, blood coagulation resisting function increases FA, improves hemorheological property, Reduce the effect that the links such as blood viscosity reach treatment.Ren Jixue distinguished veteran doctors of TCM thinks that disease and evil enters network, must activate blood circulation and disperse blood clots, and extravasated blood is not OK, new blood breaks without life, and new life to be caused must first push away old, leads to and mends parallel, often adds promoting circulation of blood medicine in tonic, and its work(is prompt again, dispels silt not Just because " quenching one's thirst " is with the deficiency of Yin as this, extravasated blood is that pathological product is again paathogenic factor to wound, to be noted when application activates blood circulation and disperses blood clots Meaning turns round and look at shield qi and blood and nourishes cloudy liquid, accomplish to dispel silt and will not gas consumption impairment of yin, it is evil that yin-nourishing will not stay bandit to love again, is preferably treated to reach Effect.Diabetes are again treatment cycle diseases more long, to formulate a treatment plan for long-term suitable personal feature, are reached To dispel become silted up do not hinder just, " with lead to be mend " effect.
It is the effective way for treating diabetes that proposition activates blood circulation and disperses blood clots, and should run through treating diabetes medicine for treatment principle all the time, For improve therapeutic effect have positive effect, adjustment internal organs qi and blood function, treat both principal and secondary aspect of disease, silt of dispelling is not hindered just.
The clinical test of pesticide effectiveness
Method:By 220 clinical definite diabetics, the difference between individual patients is negligible, and its is random It is divided into experimental group 1-8, control group 1-2 and melbine group, every group 20, the Chinese traditional medicine composition of embodiment 1-8 preparations is taken respectively Chinese medicine composition and commercially available melbine prepared by thing, control group 1-2, are continuously taken 10 days, and observation clinical efficacy result is shown in Stop other western medicines in treatment during table 1, treatment.
Diagnostic criteria:Formulated within 1993 with reference to the Ministry of Public Health《New Chinese medicine guideline of clinical investigations》In " treatment disappears The standard rating curative effect of the guideline of clinical investigations of thirsty disease " defined.It is effective:Symptom disappears substantially after treatment, and FPG is (on an empty stomach Blood sugar) < 7.0mmol/L, P2hPG (2 hours blood glucose after the meal) < 8.3mmol/L or blood sugar declines more than 30% earlier above;Effectively: Symptom is obviously improved after treatment, and FPG < 8.3mmol/L, P2hPG < 10.0mmol/L, or blood sugar declines 10%~29% earlier above; It is invalid:Symptom is not improved after treatment, and blood sugar declines not up to above-mentioned standard.
The Chinese medicine composition of the treatment diabetes of the present invention of table 1, control group treat the Chinese medicine composition and two of diabetes First biguanides treatment diabetes clinical efficacy result statistics.
Wherein, total effectively case load=(effective+effective) in table.As it can be seen from table 1 Chinese medicine composition of the present invention Clinically, preferable curative effect is achieved, in selected diabetic, Chinese traditional medicine composition described in embodiment of the present invention 1-8 is taken After thing 10 days, obvious effective rate is up to 80.0%, and total effective rate is up to 95%;Particularly embodiment 3, total effective rate is up to 100%.It is right 2 groups of ratio is similar with melbine group clinical efficacy.Illustrate that the Chinese Herbs of the treatment diabetes of present invention offer are more protruded, Meanwhile, by contrast, compatibility and weight ratio in embodiment 3 and the explanation inventive formulation of comparative example 1,2 between each medicine are shadows The key factor of sound curative effect of medication of the present invention.
Finally illustrate, the above embodiments are merely illustrative of the technical solutions of the present invention and it is unrestricted, this area is common Other modifications or equivalent that technical staff is made to technical scheme, without departing from technical solution of the present invention Spirit and scope, all should cover in the middle of scope of the presently claimed invention.

Claims (7)

1. a kind of Chinese medicine for treating diabetes, it is characterised in that:By weight meter:5-15 grams of the red sage root, 3-10 grams of safflower, the dried rhizome of rehmannia, Each 15-25 grams of Chinese yam;Each 5-15 grams of the fruit of Chinese magnoliavine, the root of kudzu vine;Each 10-15 grams of clam meal, bryozoatum;10-20 grams of root of Chinese trichosanthes, the membrane of a chicken's gizzard 3- 7 grams, watermelon peel, each 10-20 grams of waxgourd peel, 50-70 grams of mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, each 5-15 grams of Radix Codonopsis, 25-35 grams of gypsum With 10-15 grams of composition of radix scrophulariae.
2. a kind of Chinese medicine for treating diabetes according to claim 1, it is characterised in that:By weight meter:Red sage root 8-10 Gram, 5-8 grams of safflower, the dried rhizome of rehmannia, each 18-22 grams of Chinese yam;Each 8-12 grams of the fruit of Chinese magnoliavine, the root of kudzu vine;Each 12-14 grams of clam meal, bryozoatum;Smallpox 13-18 grams of powder, 4-6 grams of the membrane of a chicken's gizzard, watermelon peel, each 12-18 grams of waxgourd peel, 55-65 grams of mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, each 8- of Radix Codonopsis 12 grams, 12-14 grams of composition of 28-32 grams of gypsum and radix scrophulariae.
3. a kind of Chinese medicine for treating diabetes according to claim 1, it is characterised in that:By weight meter:10 grams of the red sage root, Each 20 grams of 6 grams of safflower, the dried rhizome of rehmannia, Chinese yam;Each 10 grams of the fruit of Chinese magnoliavine, the root of kudzu vine;Each 12 grams of clam meal, bryozoatum;15 grams of root of Chinese trichosanthes, the membrane of a chicken's gizzard 5 grams, watermelon peel, 12 grams of each 15 grams of waxgourd peel, 60 grams of mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, each 10 grams of Radix Codonopsis, 30 grams of gypsum and radix scrophulariae Composition.
4. the preparation method of the Chinese medicine of a kind for the treatment of diabetes according to claim any one of 1-3, it is characterised in that:Including Following steps:
1)Clam meal, bryozoatum and gypsum are mixed and is decocted, filtering takes supernatant;
2)By the red sage root, the dried rhizome of rehmannia, Chinese yam, the fruit of Chinese magnoliavine, the root of kudzu vine, root of Chinese trichosanthes, watermelon peel, waxgourd peel, mantis egg-case, the wind-weed, the tuber of dwarf lilyturf, Radix Codonopsis With radix scrophulariae cleaning, crush and add ethanol water 30-50 minutes, extract effective ingredient;
3) supercritical CO is loaded after safflower is crushed2Supercritical CO is carried out in extraction kettle2Extraction, the Stress control of extraction is in extraction Pressure 8-12MPa, 40-60 DEG C of extraction temperature is obtained safflower effective ingredients standby;
4)The membrane of a chicken's gizzard is decocted and fried, crushed, with step 1), step 2)With step 3)Gained effective ingredient mixes, is condensed into The medicinal extract of 1.3-1.8g/ml;
5)By step 4)Gained extract dry, preparation.
5. preparation method according to claim 4, it is characterised in that:Step 2)The weight fraction of the ethanol water is 65wt-75wt%。
6. preparation method according to claim 4, it is characterised in that:Step 5)The dry condition is-78-- 60 DEG C Freeze-drying 12-20 hours.
7. preparation method according to claim 4, it is characterised in that:Step 5)The preparation, by the medicinal extract and pharmacy On auxiliary material be mixed, the formulation include oral liquid, granule, tablet, pill, powder, capsule, pill and injection Agent.
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