CN105233075A - Traditional Chinese medicine combination treating coronary heart disease - Google Patents
Traditional Chinese medicine combination treating coronary heart disease Download PDFInfo
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- CN105233075A CN105233075A CN201510817209.1A CN201510817209A CN105233075A CN 105233075 A CN105233075 A CN 105233075A CN 201510817209 A CN201510817209 A CN 201510817209A CN 105233075 A CN105233075 A CN 105233075A
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Abstract
The invention provides a traditional Chinese medicine combination treating the coronary heart disease. The combination is prepared from persimmon leaves, light wheat, lilies, rhizomes of rehmannia and other traditional Chinese medicine raw materials. The combination is unique in medicine component, precise in formula and refined in selected medicine, the medicine components collaboratively act and supplement each other. The combination has the functions of benefiting qi and nourishing yin, decreasing internal heat and dredging channels, activating blood and calming down the heart, tonifying qi and strengthening the spleen, removing phlegm and removing blood stasis and the like. The combination has a very good curative effect on the coronary heart disease and can also eliminate the symptoms of fatty liver, hyperlipidemia, hyperglycemia and the like.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of coronary heart disease.
Background technology
Coronary atherosclerotic heart disease is coronary artery generation atherosclerotic lesion and causes lumen of vessels stenosis or occlusion, causes myocardial ischemia, anoxia or downright bad and heart disease that is that cause, is usually called as " coronary heart disease ".Mostly occur after 40 years old, old people is more.Coronary artery supply heart self-blood, there is seriously atherosis or spasm in coronary artery, makes coronary stricture or obturation, cause myocardial ischemia-anoxemia or infarction, clinical symptoms has uncomfortable in chest, nervous, dyspnea, precordialgia, also has the disease generations such as dizzy, dizzy, tinnitus.Can arrhythmia be there is in severe patient, often because of myocardial ischemia, anoxia and cause myocardium large area downright bad, and threat to life.
Modern medicine is divided into two classes substantially to cardiopathic treatment means: one is use medicine to comprise blood vessel dilating class medicine and the molten lipid drug of thrombolytic; Two is support, bypass surgery.In the treatment of coronary heart disease, intervene operation and bypass surgery all belong to wound treatment, and postoperative complication has a strong impact on the healthy of patient simultaneously.These methods particularly significant in the rescue stage to the treatment of cardiac be effective.But side effect is also comparatively large, especially can not life-time service.
Summary of the invention
The object of the invention is to provide a kind of Chinese medicine composition for the treatment of coronary heart disease, is applicable to coronary heart diseases and angina pectoris, determined curative effect, and safety has no side effect.
Technical solution of the present invention is as follows, treat a Chinese medicine composition for coronary heart disease, each crude drug component is by weight ratio: Folium Kaki 15-30 part, Fructus Tritici Levis 5-10 part, Bulbus Lilii 6-10 part, Radix Rehmanniae 10-20 part, Fructus Citri Sarcodactylis 3-9 part, Os Draconis 5-15 part, Concha Margaritifera 5-15 part, Flos Chrysanthemi 5-9 part, RADIX SALVIAE MILTIORRHIZAE 10-50 part, Poria 20-30 part, Clematis kerriana Drumm. Et Craiab 10-20 part, Fructus Liquidambaris 10-20 part, Fructus Trichosanthis 9-15 part, Herba Ipomoeae Cairicae 20-30 part, Rhizoma Pinelliae Preparatum 10-20 part, Exocarpium Citri Rubrum 3-9 part, Caulis Bambusae In Taenia 10-20 part, Fructus Aurantii Immaturus 2-10 part, Radix Glycyrrhizae 5-10 part.
Be decocted in water for oral dose, by above-mentioned weight portion weighting raw materials with 5 pieces, Fructus Jujubae, 1000 milliliters, clear water, soaks 30 minutes, boils latter 30 minutes at a simmer, decocts 2 times, and merging medicinal liquid is 1 dose.One day 1 dose, point taking for 2 times, 30 days is a course for the treatment of.
Coronary heart disease is called the thoracic obstruction in the traditional Chinese medical science, and so-called " numbness " is exactly that impatency is obstructed, i.e. coronary artery blockage or narrow.Treatment by Chinese herbs needs blood circulation promoting and blood stasis dispelling, coronary circulation-promoting pain-relieving.Coronary heart disease treatment more holistic is seen, although the sick position of coronary heart disease is at the heart, with lung, spleen, liver, kidney close relation.Medicament composing prescription of the present invention is unique, formula is rigorous, select YAOJING to refine, and each component drug synergism, complements each other.There is supplementing QI and nourishing YIN, pathogenic fire reducing promoted blood circulation, mind calming of invigorating blood circulation, air making-up and spleen enlivening, the effects such as the stasis of blood are led in expectorant.Not only there is good curative effect to coronary heart disease, the symptoms such as fatty liver, hyperlipidemia, hyperglycemia can also be eliminated.
The pharmacological action of each medicine of the present invention is as follows:
Folium Kaki: [nature and flavor] are bitter; [return through] cold in nature lung meridian [function cures mainly] relieving cough and relieving asthma; Promoting the production of body fluid to quench thirst; Promoting blood circulation and hemostasis.Main cough with asthma; Quench one's thirst and various internal hemorrhage; Earn the flavonoid glycoside that skin ulcer [pharmacological action] proposes from leaf, to Canis familiaris L. intravenous injection (5mg/kg), can reduce blood pressure and increase coronary flow (33-36%); In extrasomatic rabbit heart specimen, also coronary flow can be increased.The injection made with leaf in vitro, has certain bacteriostasis to staphylococcus aureus, micrococcus catarrhalis.To rabbit lumbar injection, there is cooling effect.Little to the toxicity of animal, also do not cause haemolysis, do not affect end and send hemogram.
Fructus Tritici Levis: [nature and flavor] sweet in the mouth; [return through] cool in nature heart channel [function cures mainly] is except deficiency-heat; Hidroschesis.Main only fever due to yin deficiency; Night sweat; Spontaneous perspiration
Bulbus Lilii: [nature and flavor] are sweet; Micro-hardship; Be slightly cold [return through] heart; Lung meridian [function cures mainly] nourishing YIN and moistening the lung; Clearing away heart-fire for tranquillization.Main deficiency of YIN chronic cough; Sputum mixed with blood; The calentura later stage; Waste heat is clear, or the unsuccessful caused fidgets due to deficiency palpitation with fear of feelings will, insomnia and dreamful sleep, absentminded; Carbuncle; Eczema
Radix Rehmanniae: [nature and flavor] are sweet, cold.[return through] GUIXIN, liver, kidney channel.[function cures mainly] clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid.For calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis sends out speckle dermexanthesis.
Fructus Citri Sarcodactylis: [nature and flavor] are pungent, bitter, sour, temperature.[return through] returns liver, spleen, lung meridian.[function cures mainly] liver-smoothing, qi-regulating, and stomach and alleviating pain.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted.
Os Draconis: [nature and flavor] are sweet, puckery are flat.[function cures mainly] is calm, arresting sweating arresting seminal emission, promoting tissue regeneration and ulcer healing.For neurasthenia, cardiopalmus, insomnia, dreaminess, spontaneous perspiration, night sweat, seminal emission, the enuresis, metrorrhagia, leukorrhagia; External control skin infection for a long time burst do not hold back.
Concha Margaritifera: [nature and flavor] are salty, cold.[return through] returns liver, heart channel.[function cures mainly] suppressing the hyperactive liver and subsiding YANG, arresting convulsion improving eyesight.Dizzy for having a headache, irritated insomnia, liver-heat conjunctival congestion, deficiency of the liver blurred vision.
Flos Chrysanthemi: [nature and flavor] are sweet, bitter, are slightly cold.[return through] returns lung, Liver Channel.[function cures mainly] falls apart wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.
RADIX SALVIAE MILTIORRHIZAE: [nature and flavor] are lightly seasoned; Micro-hardship; Cool in nature.[function cures mainly] invigorating the kidney and strengthening the bones; Promoting blood flow to regulate menstruation; Cooling blood for hemostasis.Main lumbago due to renal deficiency; Rheumatalgia; Dizzy; Menoxenia; Dysmenorrhea; Amenorrhea; Metrorrhagia; Have blood in stool; Spit blood; Epistaxis; Traumatic injury stasis of blood pain; Knife injury is hemorrhage.
Poria: [nature and flavor] are sweet, light is flat.[return through] GUIXIN, lung, spleen, kidney channel.[function cures mainly] promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Clematis kerriana Drumm. Et Craiab: [nature and flavor] bitter in the mouth; Light; Micro-pungent; Cold nature [function cures mainly] heat-clearing and toxic substances removing; Diuresis; Eliminating blood stasis and smoothing collaterals.Main carbuncle sore furuncle and phyma; Mastitis; Edema; Dysuria; The difficulty in urination; Traumatic injury
Fructus Liquidambaris: [nature and flavor] are bitter is flat.[return through] returns liver, kidney channel.[function cures mainly] dispelling, collateral-activating, diuretic stimulates the menstrual flow.For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.
Rhizoma Pinelliae Preparatum: [nature and flavor] are pungent, warm.[return through] returns spleen, stomach, lung meridian.[function cures mainly] drying dampness to eliminate phlegm.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache.
Fructus Trichosanthis: [nature and flavor] sweet, micro-hardship, cold.[return through] returns lung, stomach, large intestine channel.[function cures mainly] clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturizes laxation.For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, and acute appendicitis swells and ache, constipation.
Herba Ipomoeae Cairicae: [nature and flavor] are sweet; Micro-hardship; Property flat [function cures mainly] expelling wind and removing dampness; Removing blood stasis to reduce swelling.Main air wets flaccidity syndrome and arthralgia syndrome; Lumbago and skelalgia; Dysentery; Edema; Leukorrhagia; Scrofula; Traumatic injury; Amenorrhea; Breast is few
Exocarpium Citri Rubrum: [nature and flavor] are pungent, bitter, temperature.[return through] returns lung, spleen channel.[function cures mainly] cold expelling, dampness, promoting the circulation of QI, expectorant.For cough due to wind and cold, itching of the throat abundant expectoration, food stagnation is got sick from drinking too much wine, and vomiting and nausea painful abdominal mass is vexed.
Caulis Bambusae In Taenia: [nature and flavor] are sweet, are slightly cold.[return through] attaches to the lung and stomach meridians.[function cures mainly] removing heat-phlegm, relieves restlessness and prevents vomiting.For phlegm-heat cough, expectorant held under the arm by gallbladder fire, and dysphoria with smothery sensation is vomitted, and eye is lost in palpitation with fear, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement.
Fructus Aurantii Immaturus: [nature and flavor] are bitter, pungent, sour, temperature.[return through] returns spleen, stomach warp.[function cures mainly] dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm.Stop in stagnant, feeling of fullness distending pain, heavy after dysentery, constipation, the stagnant vapour lock thoracic obstruction of expectorant, blocked-up chest; Gastroptosis, proctoptosis, uterine prolapse.
Radix Glycyrrhizae: [nature and flavor] are sweet, flat.[return through] GUIXIN, lung, spleen, stomach warp.[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Detailed description of the invention
Below by embodiment and test example, the invention will be further described.But the present invention is not limited to described in embodiment, those of ordinary skill in the art do some amendment, all in scope.
Embodiment 1. 1 kinds treats the Chinese medicine composition of coronary heart disease, and each crude drug component is by weight ratio: Folium Kaki 15 grams, Fructus Tritici Levis 5 grams, Bulbus Lilii 6 grams, 10 grams, the Radix Rehmanniae, Fructus Citri Sarcodactylis 3 grams, Os Draconis 5 grams, Concha Margaritifera 5 grams, Flos Chrysanthemi 5 grams, RADIX SALVIAE MILTIORRHIZAE 10 grams, 20 grams, Poria, Clematis kerriana Drumm. Et Craiab 10 grams, Fructus Liquidambaris 10 grams, Fructus Trichosanthis 9 grams, Herba Ipomoeae Cairicae 20 grams, Rhizoma Pinelliae Preparatum 10 grams, Exocarpium Citri Rubrum 3 grams, Caulis Bambusae In Taenia 10 grams, Fructus Aurantii Immaturus 2 grams, 5 grams, Radix Glycyrrhizae.
Be decocted in water for oral dose, medicine-feeding is with 5 pieces, Fructus Jujubae, and 1000 milliliters, clear water, soaks 30 minutes, boils latter 30 minutes at a simmer, decocts 2 times, and merging medicinal liquid is 1 dose.One day 1 dose, point taking for 2 times, 30 days is a course for the treatment of.
Embodiment 2. 1 kinds treats the Chinese medicine composition of coronary heart disease, and each crude drug component is by weight ratio: Folium Kaki 30 grams, Fructus Tritici Levis 10 grams, Bulbus Lilii 10 grams, 20 grams, the Radix Rehmanniae, Fructus Citri Sarcodactylis 9 grams, Os Draconis 15 grams, Concha Margaritifera 15 grams, Flos Chrysanthemi 9 grams, RADIX SALVIAE MILTIORRHIZAE 50 grams, 30 grams, Poria, Clematis kerriana Drumm. Et Craiab 20 grams, Fructus Liquidambaris 20 grams, Fructus Trichosanthis 15 grams, Herba Ipomoeae Cairicae 30 grams, Rhizoma Pinelliae Preparatum 20 grams, Exocarpium Citri Rubrum 9 grams, Caulis Bambusae In Taenia 20 grams, Fructus Aurantii Immaturus 10 grams, 10 grams, Radix Glycyrrhizae.
Be decocted in water for oral dose, medicine-feeding is with 5 pieces, Fructus Jujubae, and 1000 milliliters, clear water, soaks 30 minutes, boils latter 30 minutes at a simmer, decocts 2 times, and merging medicinal liquid is 1 dose.One day 1 dose, point taking for 2 times, 30 days is a course for the treatment of.
Embodiment 3. 1 kinds treats the Chinese medicine composition of coronary heart disease, and each crude drug component is by weight ratio: Folium Kaki 20 grams, Fructus Tritici Levis 8 grams, Bulbus Lilii 8 grams, 15 grams, the Radix Rehmanniae, Fructus Citri Sarcodactylis 5 grams, Os Draconis 10 grams, Concha Margaritifera 10 grams, Flos Chrysanthemi 6 grams, RADIX SALVIAE MILTIORRHIZAE 30 grams, 25 grams, Poria, Clematis kerriana Drumm. Et Craiab 15 grams, Fructus Liquidambaris 15 grams, Fructus Trichosanthis 12 grams, Herba Ipomoeae Cairicae 25 grams, Rhizoma Pinelliae Preparatum 15 grams, Exocarpium Citri Rubrum 6 grams, Caulis Bambusae In Taenia 15 grams, Fructus Aurantii Immaturus 8 grams, 7 grams, Radix Glycyrrhizae.
Be decocted in water for oral dose, medicine-feeding is with 5 pieces, Fructus Jujubae, and 1000 milliliters, clear water, soaks 30 minutes, boils latter 30 minutes at a simmer, decocts 2 times, and merging medicinal liquid is 1 dose.One day 1 dose, point taking for 2 times, 30 days is a course for the treatment of.
Embodiment 4. 1 kinds treats the Chinese medicine composition of coronary heart disease, and each crude drug component is by weight ratio: Folium Kaki 25 grams, Fructus Tritici Levis 8 grams, Bulbus Lilii 8 grams, 15 grams, the Radix Rehmanniae, Fructus Citri Sarcodactylis 8 grams, Os Draconis 8 grams, Concha Margaritifera 8 grams, Flos Chrysanthemi 8 grams, RADIX SALVIAE MILTIORRHIZAE 40 grams, 26 grams, Poria, Clematis kerriana Drumm. Et Craiab 18 grams, Fructus Liquidambaris 18 grams, Fructus Trichosanthis 12 grams, Herba Ipomoeae Cairicae 26 grams, Rhizoma Pinelliae Preparatum 18 grams, Exocarpium Citri Rubrum 5 grams, Caulis Bambusae In Taenia 17 grams, Fructus Aurantii Immaturus 8 grams, 8 grams, Radix Glycyrrhizae.
Be decocted in water for oral dose, medicine-feeding is with 5 pieces, Fructus Jujubae, and 1000 milliliters, clear water, soaks 30 minutes, boils latter 30 minutes at a simmer, decocts 2 times, and merging medicinal liquid is 1 dose.One day 1 dose, point taking for 2 times, 30 days is a course for the treatment of.
The present invention is used for the treatment of coronary heart diseases and angina pectoris, determined curative effect, and achieves promising result through clinical trial.Not only there is good curative effect to coronary heart disease, the symptoms such as fatty liver, hyperlipidemia, hyperglycemia can also be eliminated.Through making a definite diagnosis, 80 routine patients with coronary heart disease to be treated, total effective rate 97.5%, and at medication treatments period without finding that there is any untoward reaction and toxic and side effects, showing drug safety, effectively.
One, clinical data
Select in August, 2012 to 2014 a year December go to a doctor patients with coronary heart disease patient 80 example, this group case all meets diagnostic criteria for coronary heart disease.
Two, Therapeutic Method
Adopt treatment by Chinese herbs of the present invention, one month each course for the treatment of, by one or two course of therapy.
Three, result
Curative effect determinate standard: formulate with reference to " the clinical trial guideline of new Chinese medicine treatment cardiopalmus ", " traditional Chinese medical science cardiopathia Standardization of diagnosis and curative effect and medication specification ".The traditional Chinese medical science with cardiopalmus, breathe hard, the large symptom of uncomfortable in chest, chest pain four is the starting point, after a course for the treatment of or two courses for the treatment of, as all diseases are improved, obviously to be improved or clinical recovery person is effective.After treatment, if all diseases are invalid without obvious advance and retreat person.Total effective rate 97.5%.
Model case 1: patient Wang, female, 64 years old, because of " big belly 4 years repeatedly, the heart tires out March, increases the weight of " to be admitted to hospital for 10 days, before 4 years, there is big belly without inducement in patient, has nothing to do with diet, obvious when putting down sleeping, alleviate during seat, without fainting and amaurosis, without panting, spitting blood, without uncomfortable in chest, hectic fever, night sweat, unconscious obstacle and the dyskinesia etc.Before March, patient's above-mentioned symptom is sent out again, and the heart is obviously tired, and the two lower limbs edema of companion, without taking a turn for the better after treating to commune hospital with " chronic gastritis ".Before 10 days, patient's heart is cumulative heavy, and night can not put down sleeping.It is in being diagnosed as " hypertension " before 2 years, and maximal blood pressure 160/98mmHg, oral medicine is treated.Be diagnosed as " type 2 diabetes mellitus " before 1 year, oral medicine is treated.Human health screening tentative diagnosis: suffer from coronary atherosclerotic heart disease, 1.1 decline whole-heartedly, 1.1.1 bilateral pleural effusion, 1.2 Ⅲcardiac functions; With hypertension 2 grades of high danger; And type 2 diabetes mellitus.Give Drug therapy of the present invention after two months not only coronary heart disease symptom be clearly better, hypertension and diabetes are also effectively controlled.Fully recover after continuing to take half a year.
Model case 2: Lee, female, 51 years old, there is sensation of oppression over the chest with shortness of breath and dizziness without obvious cause in patient's private prosecution 5+ before being admitted to hospital, time with cardiopalmus, aggravation time tired, can alleviate through having a rest, outpatient service measuring blood pressure of once repeatedly seeing a doctor finds hypertension, reaches as high as 210/110mmHg.Look into electrocardiogram prompting " deficiency myocardial blood supply ", be diagnosed as " coronary heart disease, primary hypertension ", give blood pressure lowering, expand the Western medicine oral medications such as blood vessel, symptom all can be alleviated, but is easy to repeatedly.Within nearly 10 days, comparatively before increase the weight of without obvious cause sense symptom, chest dull pain, time when doing only, companion's shortness of breath and palpitation, has a dizzy spell, especially obvious afterwards with activity.But fearless cold heating, headache vomiting, dyspnea, abdominal pain and distension, cough and expectoration, otopathy deafness, aphasia hemiplegia etc.Treatment is not given outside institute.After being admitted to hospital, after having a medical check-up, tentative diagnosis is coronary heart disease and essential hypertension 3 grades.Although because taking Western medicine relief of symptoms but being easy to repeatedly, long-term taking causes uncomfortable.Therefore give treatment by Chinese herbs of the present invention after 40 days coronary heart disease symptom be clearly better, hypertension is also effectively controlled.After continuing to take three months, fundamental symptoms is eliminated, drug withdrawal of fully recovering after continuing to take half a year.
Claims (3)
1. treat the Chinese medicine composition of coronary heart disease for one kind, it is characterized in that, each crude drug component is by weight ratio: Folium Kaki 15-30 part, Fructus Tritici Levis 5-10 part, Bulbus Lilii 6-10 part, Radix Rehmanniae 10-20 part, Fructus Citri Sarcodactylis 3-9 part, Os Draconis 5-15 part, Concha Margaritifera 5-15 part, Flos Chrysanthemi 5-9 part, RADIX SALVIAE MILTIORRHIZAE 10-50 part, Poria 20-30 part, Clematis kerriana Drumm. Et Craiab 10-20 part, Fructus Liquidambaris 10-20 part, Fructus Trichosanthis 9-15 part, Herba Ipomoeae Cairicae 20-30 part, Rhizoma Pinelliae Preparatum 10-20 part, Exocarpium Citri Rubrum 3-9 part, Caulis Bambusae In Taenia 10-20 part, Fructus Aurantii Immaturus 2-10 part, Radix Glycyrrhizae 5-10 part.
2. the Chinese medicine composition for the treatment of coronary heart disease as claimed in claim 1, it is characterized in that, each crude drug component is by weight ratio: Folium Kaki 20 parts, Fructus Tritici Levis 8 parts, Bulbus Lilii 8 parts, 15 parts, the Radix Rehmanniae, Fructus Citri Sarcodactylis 5 parts, Os Draconis 10 parts, Concha Margaritifera 10 parts, Flos Chrysanthemi 6 parts, RADIX SALVIAE MILTIORRHIZAE 30 parts, 25 parts, Poria, Clematis kerriana Drumm. Et Craiab 15 parts, Fructus Liquidambaris 15 parts, Fructus Trichosanthis 12 parts, Herba Ipomoeae Cairicae 25 parts, Rhizoma Pinelliae Preparatum 15 parts, Exocarpium Citri Rubrum 6 parts, Caulis Bambusae In Taenia 15 parts, Fructus Aurantii Immaturus 8 parts, 7 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of coronary heart disease as claimed in claim 1 or 2, it is characterized in that, weighting raw materials is with 5 pieces, Fructus Jujubae by weight, 1000 milliliters, clear water, soaks 30 minutes, boils latter 30 minutes at a simmer, decocts 2 times, and merging medicinal liquid is 1 dose.
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Application publication date: 20160113 |