CN109045243A - Chinese medicine composition, preparation and preparation method thereof for treating infant hemangioma - Google Patents
Chinese medicine composition, preparation and preparation method thereof for treating infant hemangioma Download PDFInfo
- Publication number
- CN109045243A CN109045243A CN201811144458.9A CN201811144458A CN109045243A CN 109045243 A CN109045243 A CN 109045243A CN 201811144458 A CN201811144458 A CN 201811144458A CN 109045243 A CN109045243 A CN 109045243A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- radix
- medicine composition
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The Chinese medicine composition that the invention discloses a kind of for treating infant hemangioma, preparation and preparation method thereof, the Chinese medicine composition includes the substance of following parts by weight: 1-5 parts of thallus laminariae, 1-5 parts of seaweed, 1-5 parts of Radix Salviae Miltiorrhizae, 1-5 parts of radix paeoniae rubra, 1-5 parts of Radix Angelicae Sinensis, 1-5 parts of Radix Rehmanniae, 1-5 parts of radix scrophulariae, 1-5 parts of turmeric.Chinese medicine composition of the invention, using thallus laminariae, seaweed as monarch drug in a prescription, fundamentally blood circulation promoting and dispersing pathogen accumulation, dissolving phlegm Li Shui, make illness obtain basic control；Using Radix Salviae Miltiorrhizae, radix paeoniae rubra as ministerial drug, the effect of assisting monarch drug in a prescription blood circulation promoting and dispersing pathogen accumulation, and there is clearing heat and detoxicating effect；Using Radix Angelicae Sinensis, Radix Rehmanniae as adjutant, immunity of organisms is adjusted, improves drug effect；Using radix scrophulariae, turmeric as medicine is made, monarch drug in a prescription and ministerial drug are assisted；This side's all medicines share, the monarch and his subjects pull together, and minister assistant is auxiliary altogether, can effectively treat hemangioma cutis, and uneasy to recur, and total effective rate uses natural traditional Chinese medicine for raw material up to 97.5%, curative for effect and have no toxic side effect.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine more particularly to a kind of for treating the Chinese medicine group of infant hemangioma
Close object, preparation and preparation method thereof.
Background technique
Hemangioma (hemangioma) is also known as infant hemangioma (infantile hemangioma, IH), is baby children
The most common benign tumour of youngster is true property vascular tumor, caused by the normal vascular tissues hyper-proliferative of mesoderm.Hemangioma is good
It sends out in head, face, neck, is secondly four limbs and trunk.Incidence is 1.1%~2.6% in newborn, at birth there are about 30%
I.e. visible, usually after birth 2 weeks or 4 weeks whens, slowly grow, thus incidence at 1 years old is 10%~12%.Girl baby compared with
Boy baby be it is more, ratio is 2~5:1, and more originator account for 15%~30%.Infant hemangioma has unique growth cycle: most
Knurl is not as it can be seen that a couple of days to several weeks after birth occur infant suddenly at birth, and then rapid growth, the process can be held
Continuous June was differed to 1 year, referred to as angiomatous proliferative phase.Gradually voluntarily subside afterwards, and continues 5-10.When by 5 years old, about 50%
Knurl can subside completely.Exactly this unique growth characteristics, make it be different from other hemangiomas and vascular malformation.However,
Although hemangioma can voluntarily subside, still there is about 10% infant to occur ulcer, infection, pain in the course of disease, or even blind, stop up
Breath etc. severe complications, in addition its easily be apt to occur in face feature, become puzzlement infant and parent psychology it is important because
Element.
Infant hemangioma is divided into primary and two kinds secondary, and wherein primary accounts for 75%, secondary 25% or so.After
Hair property majority occurs in infancy, a small number of to find in the manhood, and the cause of disease is unclear.Primary, that is, congenital viviparity is by people
Body embryonic period, embryonic phase rete vasculosum hyperplasia and formed, when birth, has, can be asymptomatic when hemangioma is smaller.It is each that hemangioma can betide body
Position is grown in face and four limbs exposure portion, can influence appearance.The function of surrounding tissue organ is oppressed, destroyed to some extent
Energy and form, influence the growth and development of human body.What is had can be with Repeated Hemorrhage, infection, and only a few people can generate canceration, or even jeopardize
Life.
Current treatment method mainly has: operation excision, cold therapy and sclerosing treatment etc., when operative treatment, often go out
Blood volume is very big, usually causes serious haemorrhagic shock, needs largely to input whole blood in art, and operating difficulty is big, and degree of danger is high.
Cold therapy due to refrigeration operation intensity difficult to control and depth, while organizing the resilience to low temperature different, occurs treating not
Thoroughly, recurrence is higher, and directly affects therapeutic evaluation；In addition the local scar ectogenic teratism dysfunction left be also not by
But if that patient is expected as a result, there is not such situation, often treatment is invalid.Hardening is injected into blood by sclerosing treatment
It (cannot be injected in blood vessel) in tuberculation knurl tissue, local fibrosis reaction occur after causing aseptic inflammation, swelling to disappear, make
Hemangioma, lumen of vessels reduce or occlusion；Common drug has: 1. sodium morrhuate；2. withered hemorrhoid spirit injection；3. Alum Injection；
4. alumen coptis root injection；5. sodium bicarbonate injection；6. bleomycin A5, bleomycin class of fighting；7. boiling water injection treatment；8. urea
Injection；Treatment hemangioma has certain effect, if but dosage grasp be not allowed to be easy to fester and stay scar.But the above method is usual
Think the treatment for not being suitable for infant.
Existing drug makes some progress in terms for the treatment of hemangioma, but there are cure rates not high, healing time
Long, the disadvantages of there are scar or scars after strong, skin allergy, healing to normal skin irritation, infant's body is seriously affected
Heart growth.And develop cure rate height, do not recur, without scar or scar, the Chinese traditional medicine composition prepared specifically for infant hemangioma
Object is the significant technology issues of pharmaceutical technology field researcher.
Summary of the invention
It is an object of the invention to overcome the defect of the prior art, provide a kind of for treating in infant hemangioma
Drug composition, preparation and preparation method thereof, the present invention use natural traditional Chinese medicine for raw material, curative for effect and have no toxic side effect, and can have
Effect cures infant hemangioma and uneasy to recur, effective percentage up to 97.5%.
The present invention is implemented as follows:
It is an object of the present invention to provide a kind of for treating the Chinese medicine composition of infant hemangioma, the Chinese medicine group
Close the substance that object includes following parts by weight: 1-5 parts of thallus laminariae, 1-5 parts of seaweed, 1-5 parts of Radix Salviae Miltiorrhizae, 1-5 parts of radix paeoniae rubra, 1-5 parts of Radix Angelicae Sinensis, raw
Ground 1-5 parts, 1-5 parts of radix scrophulariae, 1-5 parts of turmeric.
The second object of the present invention is to provide a kind of for treating the preparation side of the Chinese medicine composition of infant hemangioma
Method includes the following steps:
Step 1 weighs the thallus laminariae, seaweed, Radix Salviae Miltiorrhizae, radix paeoniae rubra, Radix Angelicae Sinensis, Radix Rehmanniae, radix scrophulariae and turmeric in proportion respectively, dries
It is crushed after dry；
Step 2, in the resulting herb powder hot water extraction of step 1, obtain the leaching liquor of different Chinese medicines；
Step 3 merges corresponding medicinal plant extraction obtained by step 2, is used to treat infant's blood up to described after water boiling concentration
The Chinese medicine composition of tuberculation.
The third object of the present invention is to provide the dosage form of the preparation of Chinese medicine composition described in one kind, it includes any described
Chinese medicine composition and pharmaceutically acceptable carrier, the dosage form include tablet, pulvis, capsule, granule, gelling agent,
Emulsion, cream or spray.
Chinese medicine composition of the invention can be added customary adjuvant (starch, vegetable oil etc.), be made according to a conventional method clinically
Acceptable tablet, pulvis, capsule, granule, gelling agent, emulsion, cream or spray.Wherein the tablet, pulvis,
Capsule, granule are for taking orally；The gelling agent, emulsion, cream or spray are used for affected part of exterior coating.
Activity is as follows the effect of each primary raw material medicine in the present invention:
1, thallus laminariae: for Laminariaceae plant sea-tangle Laminariajaponica Aresch. or Alariaceae plant kelp (the goose palm
Dish) Eckloniakurome Okam. drying thallus.Nature and flavor: it is salty, it trembles with fear.Channel tropism: return liver, stomach, kidney channel.Effect: softening hard masses dissipate
Knot, dissolving phlegm, Li Shui.For goiter, scrofula, testiclar gall, phlegm retention oedema.Record in " haigoushen ": dredging water passages remove edema of the face, go
Malignant sore mouse fistula.
2, seaweed: for Sargassaceae plant Sargassum Sargassum pallidum (Turn.) C.Ag. or sargassum fusifome
The drying frond of Sargassum fusiforme (Harv.) Setch..Nature and flavor: it is bitter, salty, it trembles with fear.Return liver, stomach, kidney channel.Effect: soft
Hard dissipating bind, dissolving phlegm, Li Shui.For goiter, scrofula, testiclar gall, phlegm retention oedema.It records: being gathered between treatment skin, cruelly in " Bie Lu "
Huang stays gas, heat knot, diuresis.Seaweed nature and flavor are salty, have the effect of dissolving phlegm softening hard masses, inducing diuresis for removing edema, ancient times most herbal works notes
The pharmacological property and drug effect and thallus laminariae " also without big different " of load seaweed, only " property of thallus laminariae, hero is in seaweed ", the two mutually must be used, and increase
The effect of adding its reducing phlegm and resolving masses.
3, Radix Salviae Miltiorrhizae: dicotyledon Lamiaceae Salvia category perennial vertical herbage plant.Nature and flavor: it is bitter, it is slightly cold, it is nontoxic.
It is inducing meastruation to relieve menalgia with promoting blood circulation, the effect of relieving restlessness and restlessness, cool blood to disappear carbuncle.In addition there are dissolving stasis, raw new, promoting blood circulation, menstruation regulating are equivalent
With, it is gynaecology's key medicine, cures mainly uterine hemorrhage, irregular menstruation, blood stasis, abdominal pain, dysmenorrhoea, menostasis, mausoleum pain.Have to treatment coronary heart disease good
Good effect.Furthermore the weak insomnia of nerve is also controlled, arthralgia, anaemia, mazoitis, adenolymphitis, arthritis, boil pain is swollen, red
Poison, acute, chronic hepatitis, nephropyelitis, traumatic injury, advanced schistosomiasis hepatosplenomegaly , Dian Epilepsy.External application can wash dermatitis rhus again.
4, radix paeoniae rubra: for the dry root of ranunculaceae plant radix paeoniae rubra or river radix paeoniae rubra.Nature and flavor: bitter, slightly cold, return liver warp.With yin-nourishing,
The effect of row stasis of blood, analgesic, cool blood, detumescence.The major functions: controlling under the stagnant menostasis of the stasis of blood, the accumulation of hernia lump in the abdomen, abdominal pain, hypochondriac pain, bleeding from five sense organs or subcutaneous tissue, bloody flux, intestines wind
Blood, hot eyes, carbuncle swells, injury from falling down.Radix Salviae Miltiorrhizae and radix paeoniae rubra are common compatibilities, have blood circulation invigorating efficacies.
5, Radix Angelicae Sinensis: nature and flavor: it is sweet, pungent, warm, return liver, the heart, the spleen channel.With benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizing dryness and lubricating intestine resists
Cancer, anti-ageing the effect of preventing always, is immune.
6, Radix Rehmanniae: it is sweet in flavor, it trembles with fear.Green blood cool blood cures mainly folding and falls, exhausted muscle, in wound, by blood-arthralgia, fills out marrow, long muscle.
7, radix scrophulariae: for the root of Scrophulariaceae herbaceos perennial radix scrophulariae.Meridian distribution of property and flavor: bitter, sweet, salty, cold.Return lung, stomach, kidney
Through.Effect: clearing heat and cooling blood, detoxicating and resolving a mass, Yin-nourishing and body fluid promoting.The major functions: join the army point for heat, fever aggravated at night, blood-head macular eruption, throat swells
Bitterly, carbuncle sore tumefacting virus, dry constipation of intestines.Radix scrophulariae matches Radix Rehmanniae: the two is all good dose of heat clearing and blood cooling class drug and nourishing Yin and promoting production of body fluid.Two
Person's mutual reinforcement between compatibility, can be not only used for real example, it can also be used to asthenic symptoms.The inclined cooling blood and hemostasis of Radix Rehmanniae function, the inclined removing pattogenic heat from the blood and toxic material from the body of radix scrophulariae function, the two are same
Enter blood system, greatly enhance clearing away heat,cooling blood and removing toxin effect, be usually used in frenzied delirious speech, macula appears or spit blood, bleeding from five sense organs or subcutaneous tissue, the deep red tongue fur of tongue it is few
Equal heat invading xuefens card.Radix Rehmanniae and radix scrophulariae have stronger nourishing Yin and promoting production of body fluid to act on again, are used for the pyreticosis later period, and body fluid damages, restlessness and thirst,
The sore-throat of constipation or damage of kidney-YIN, flaring up of deficient fire is swollen, and the card such as mouth parched and tongue scorched also has good therapeutic effect.
8, turmeric: the rhizome of Zingiber herbaceos perennial turmeric.Nature and flavor: pungent, bitter, temperature.Effect: blood-breaking, promoting the circulation of qi are led to
Through analgesic.Control trusted subordinate's feeling of fullness distending pain, brachialgia, abdominal mass, women's blood stasis, the postpartum stasis of blood stops abdominal pain, injury from falling down, carbuncle swells.Turmeric
With Radix Angelicae Sinensis, Radix Angelicae Sinensis Gan Wenxin dissipates, and blood-nourishing and blood are inducing meastruation to relieve menalgia, and Radix Angelicae Sinensis obtains helping for turmeric, and hemostasis is gone and newborn, one feeding one broken, phase
It is inverted into；Turmeric obtains helping for Radix Angelicae Sinensis, promoting blood circulation and removing obstruction in channels, and the function that promoting the circulation of qi relieves the pain more writes, and distressed for thoracic obstruction, irregular menstruation is ached, closed
It is demonstrate,proved through equal.
Compared with prior art, the invention has the advantages that and effect:
1, provided by the invention a kind of for treating the Chinese medicine composition of infant hemangioma, using thallus laminariae, seaweed as monarch
Medicine has the function of dissipating bind dissolving phlegm Li Shui, and traditional Chinese medicine thinks, this disease is that the more cult poisons of formation of disease are invaded outside, and interior volt blood system causes
The impaired stasis of blood of channels is stagnant and causes this disease, so blood circulation promoting and dispersing pathogen accumulation, dissolving phlegm Li Shui are the basis for treating hemangioma cutis, the above 2 taste medicine
It is monarch drug in a prescription, fundamentally blood circulation promoting and dispersing pathogen accumulation, dissolving phlegm Li Shui first make illness obtain basic control；Using Radix Salviae Miltiorrhizae, radix paeoniae rubra as minister
The effect of medicine, promoting blood circulation, clearing heat and cooling blood, the above 2 taste medicine is ministerial drug, on the one hand assists monarch drug in a prescription blood circulation promoting and dispersing pathogen accumulation；On the other hand make
There is clearing heat and detoxicating effect for ministerial drug；Using Radix Angelicae Sinensis, Radix Rehmanniae as adjutant, promoting blood circulation and cooling blood adjusts immunity of organisms, improves drug effect,
Accelerate recovery from illness；Using radix scrophulariae, turmeric as medicine is made, auxiliary monarch drug in a prescription blood circulation promoting and dispersing pathogen accumulation acts on and the heat-clearing toxin-expelling functions of ministerial drug；This side is all
Medicine shares, and the monarch and his subjects pull together, and minister assistant is auxiliary altogether, has effects that blood circulation promoting and dispersing pathogen accumulation, dissolving phlegm Li Shui, clearing heat and detoxicating, adjusting immunity of organisms,
Hemangioma cutis can effectively be treated.
2, provided by the invention a kind of for treating the Chinese medicine composition of infant hemangioma, safe and non-toxic, use is safe:
Making raw material is natural medicinal plant, does not add any chemical antibacterial agent, safe and non-toxic.
3, provided by the invention a kind of for treating the Chinese medicine composition of infant hemangioma, it is possible to reduce Western medicine is to patient
The injury of body mitigates the slight illness of patient, according to clinical 80 patient views statistics, is always had using two courses for the treatment of of drug of the present invention
Efficiency 88.75%, four course for the treatment of total effective rates 97.5% are curative for effect and have no toxic side effect, and can effectively cure infant's blood vessel
Tumor and uneasy to recur.
Specific embodiment
Embodiment 1
1, a kind of for treating the Chinese medicine composition of infant hemangioma
Substance including following parts by weight: thallus laminariae 3g, seaweed 3g, Radix Salviae Miltiorrhizae 3g, radix paeoniae rubra 3g, Radix Angelicae Sinensis 3g, Radix Rehmanniae 3g, radix scrophulariae
3g, turmeric 3g.
2, the preparation method of the Chinese medicine composition
Step 1 weighs the thallus laminariae, seaweed, Radix Salviae Miltiorrhizae, radix paeoniae rubra, Radix Angelicae Sinensis, Radix Rehmanniae, radix scrophulariae and turmeric in proportion respectively, dries
It is crushed after dry；
Step 2, in the resulting herb powder hot water extraction of step 1, obtain the leaching liquor of different Chinese medicines, wherein extraction heat
Water additional amount is 10 times of inventory, and extraction carries out 3 times, and extraction temperature is 80 DEG C, and extraction time is each 2h；
Step 3 merges corresponding medicinal plant extraction obtained by step 2, water boiling concentration: the honey conduct that add weight number is 1 part
Flavoring agent intense fire infusion 20-30 minutes, turns mild fire infusion 30-40 minutes, filter liquor, and three times, merging is filtered three times for infusion repeatedly
Liquid is concentrated into 100ml to get described for treating the Chinese medicine composition of infant hemangioma.Instructions of taking: daily 100ml, point
Sooner or later one after each meal twice, 7 days as one therapeutic course.
Embodiment 2
1, a kind of for treating the Chinese medicine composition of infant hemangioma
Substance including following parts by weight: thallus laminariae 5g, seaweed 5g, Radix Salviae Miltiorrhizae 5g, radix paeoniae rubra 5g, Radix Angelicae Sinensis 1g, Radix Rehmanniae 1g, radix scrophulariae
1g, turmeric 1g.
2, the preparation method of the Chinese medicine composition
Step 1 weighs the thallus laminariae, seaweed, Radix Salviae Miltiorrhizae, radix paeoniae rubra, Radix Angelicae Sinensis, Radix Rehmanniae, radix scrophulariae and turmeric in proportion respectively, dries
It is crushed after dry；
Step 2, in the resulting herb powder hot water extraction of step 1, obtain the leaching liquor of different Chinese medicines, wherein extraction heat
Water additional amount is 10 times of inventory, and extraction carries out 3 times, and extraction temperature is 80 DEG C, and extraction time is each 2h；
Step 3 merges corresponding medicinal plant extraction obtained by step 2, water boiling concentration: the honey conduct that add weight number is 1 part
Flavoring agent intense fire infusion 20-30 minutes, turns mild fire infusion 30-40 minutes, filter liquor, and three times, merging is filtered three times for infusion repeatedly
Liquid is concentrated into 100ml to get described for treating the Chinese medicine composition of infant hemangioma.Instructions of taking: daily 100ml, point
Sooner or later one after each meal twice, 7 days as one therapeutic course.
Embodiment 3
1, a kind of for treating the Chinese medicine composition of infant hemangioma
Substance including following parts by weight: thallus laminariae 1g, seaweed 1g, Radix Salviae Miltiorrhizae 1g, radix paeoniae rubra 1g, Radix Angelicae Sinensis 2g, Radix Rehmanniae 2g, radix scrophulariae
2g, turmeric 2g.
2, the preparation method of the Chinese medicine composition
Step 1 weighs the thallus laminariae, seaweed, Radix Salviae Miltiorrhizae, radix paeoniae rubra, Radix Angelicae Sinensis, Radix Rehmanniae, radix scrophulariae and turmeric in proportion respectively, dries
It is crushed after dry；
Step 2, in the resulting herb powder hot water extraction of step 1, obtain the leaching liquor of different Chinese medicines, wherein extraction heat
Water additional amount is 10 times of inventory, and extraction carries out 3 times, and extraction temperature is 80 DEG C, and extraction time is each 2h；
Step 3 merges corresponding medicinal plant extraction obtained by step 2, water boiling concentration: the honey conduct that add weight number is 1 part
Flavoring agent intense fire infusion 20-30 minutes, turns mild fire infusion 30-40 minutes, filter liquor, and three times, merging is filtered three times for infusion repeatedly
Liquid is concentrated into 100ml to get described for treating the Chinese medicine composition of infant hemangioma.Instructions of taking: daily 100ml, point
Sooner or later one after each meal twice, 7 days as one therapeutic course.
Embodiment 4
1, a kind of for treating the Chinese medicine composition of infant hemangioma
Substance including following parts by weight: thallus laminariae 4g, seaweed 4g, Radix Salviae Miltiorrhizae 4g, radix paeoniae rubra 4g, Radix Angelicae Sinensis 5g, Radix Rehmanniae 5g, radix scrophulariae
5g, turmeric 5g.
2, the preparation method of the Chinese medicine composition
Step 1 weighs the thallus laminariae, seaweed, Radix Salviae Miltiorrhizae, radix paeoniae rubra, Radix Angelicae Sinensis, Radix Rehmanniae, radix scrophulariae and turmeric in proportion respectively, dries
It is crushed after dry；
Step 2, in the resulting herb powder hot water extraction of step 1, obtain the leaching liquor of different Chinese medicines, wherein extraction heat
Water additional amount is 10 times of inventory, and extraction carries out 3 times, and extraction temperature is 80 DEG C, and extraction time is each 2h；
Step 3 merges corresponding medicinal plant extraction obtained by step 2, water boiling concentration: the honey conduct that add weight number is 1 part
Flavoring agent intense fire infusion 20-30 minutes, turns mild fire infusion 30-40 minutes, filter liquor, and three times, merging is filtered three times for infusion repeatedly
Liquid is concentrated into 100ml to get described for treating the Chinese medicine composition of infant hemangioma.Instructions of taking: daily 100ml, point
Sooner or later one after each meal twice, 7 days as one therapeutic course.
Experimental example
1, animal acute toxicity test
Drug: the Chinese medicine composition that 1- of embodiment of the present invention embodiment 4 provides.
Experimental animal: regular grade NIH mouse, weight 18g ± 2g, half male and half female.
Method and result:
Experimental group 1-4: by Chinese medicine composition 100ml made from 1- of embodiment of the present invention embodiment 4, rice flour is added.Control
Group: the rice flour of feeding equivalent；Experiment mice is randomly divided into five groups of half male and half females, respectively experimental group 1-4 and control group, volume
1ml/10g weight, close observation 8 hours are simultaneously noted down, and observation 7 days is continued；In 7 days, for mouse without death, behavior is active, ingests
Amount is as usual, and hair color light is without loose dirt, no convulsions addicted to saliva, eye, mouth, nose, ear and crissum secretion without exception, no rotten toe of docking.
5 execution are selected from five groups respectively, finding of naked eye: the heart, liver, lung, in stomach and important organs, the no abnormality seen such as thymus gland change,
Show the Chinese medicine composition of the offer of 1- of embodiment of the present invention embodiment 4 without acute toxicity.
2, long-term toxicity test for animals
Drug: by Chinese medicine composition 100ml made from 1- of embodiment of the present invention embodiment 4, rice flour experimental group 1-4: is added.
Control group: the rice flour of feeding equivalent；
Animal: regular grade SD rat, weight 200g ± 10g, half male and half female.
Method and result:
Experimental group 1-4 and control group continue feeding 40 days repeatedly respectively, observe animal general toxic reaction and severity,
Each position is checked by operating instruction after execution, and carries out the main organs such as hematology, ALT, BUN and the heart, liver, spleen, lung, kidney, stomach
Pathological examination；
By long-term feeding, two groups of rats do not occur toxic reaction.Growth and development is good.Macroscopic appearance and main organs
No abnormality seen.Peripheral hemogram and Serum ALT, BUN change without pathologic compared with the control group.The pathological replacement heart, liver, spleen, lung,
The not significant change such as kidney, stomach, it is understood that through proved by pathology, in the offer of 1- of embodiment of the present invention embodiment 4
Drug composition shows animal without chronic toxicity.
Pass through two above toxicity test, it was demonstrated that the Chinese medicine composition safety that 1- of embodiment of the present invention embodiment 4 provides,
It has no toxic side effect, can be used to carry out clinical test to clinical patients.
Application examples
Here is clinical statistics data of the patient using drug of the present invention:
One, general information
80 accepted for medical treatment in out-patient are randomly selected, wherein male 45, women 35, max age 6 years old, most off year
Age 1 years old, course of disease some months was differed by several years.The items basic document such as two groups of patient ages, gender, courses of disease is essentially identical, difference
Not statistically significant (P > 0.05).
Two, diagnostic criteria
1, the neoformation for cerise or the aubergine of differing in size soon when being born or after birth；
2, various angiomatous skin lesion feature；
3, histopathology；
4, nevus flammeus: intradermal blood capillary proliferation and expansion；
5, hemangioma simplex: capillary and blood vessel endothelium hyperplasia in corium or subcutaneous tissue；
6, cvernous hemangioma: the lumen of vessels to differ in size in corium and subcutaneous tissue, pericyte hyperplasia.
Three, treatment method:
After being made according to the preparation method method of Chinese medicine composition provided by the invention, daily 100ml divides sooner or later meal twice
After take, 7 days as one therapeutic course.
Four, efficacy assessment standard:
1, cure: hemangioma disappears；Preventing from scar or there are inapparent scars；
2, improve: skin lesion or tumor regression, color is thin out, invades and mitigates to other organs, platelet recovery is normal, blood coagulation
Factor is normal；
3, invalid: skin lesion or tumour are without significant changes, or continue to grow up, and blood platelet and blood coagulation factor are not corrected extremely, right
The invasion of other organs or compressing do not mitigate.
Five, treatment results count:
Table 1
Wherein: total effective rate=cure rate+improvement rate
As shown in Table 1, a kind of Chinese medicine composition for treating infant hemangioma provided by the invention is in treatment skin
There is good clinical effectiveness in hemangioma, counted according to clinical 80 patient views, it is total using two courses for the treatment of of drug of the present invention
Effective percentage 88.75%, four course for the treatment of total effective rates 97.5% are curative for effect and have no toxic side effect, and can effectively cure infant's blood
Tuberculation and uneasy to recur.Significant effect has no adverse reaction and any toxic side effect.
Typical case is enumerated:
Case 1, patient Hu, male 2 years old, right arm director 1cm × 2cm × 0.4cm size cvernous hemangioma, use
2 courses for the treatment of of Chinese medicine composition that the embodiment of the present invention 4 provides, symptom decline, affected part restore good, continue 2 courses for the treatment of of medication, scar
Trace disappears, and Effect of follow-up visit by telephone half a year does not recur.
Case 2, patient's fourth, female, 15 months, cheek portion 2cm × 2cm × 0.5cm size cvernous hemangioma, using this
2 courses for the treatment of of Chinese medicine composition that inventive embodiments 1 provide, symptom decline, affected part restore good, continue 2 courses for the treatment of of medication, scar
It disappears, Effect of follow-up visit by telephone half a year does not recur.
Case 3, Dong patient, female, 26 months, facial mouth bottom right angular length 2cm × 3cm × 0.4cm size nevus flammeus,
3 courses for the treatment of of Chinese medicine composition provided using the embodiment of the present invention 1, symptom decline, affected part restore good, continue medication 2 treatments
Journey, scar disappear, and Effect of follow-up visit by telephone half a year does not recur.
Case 4, patient Zhang, male, 1 month 4 years old, right side of head was big close to temple director 2cm × 1.5cm × 0.5cm
Small hemangioma, 1 course for the treatment of of Chinese medicine composition provided using the embodiment of the present invention 3, symptom decline, affected part are restored good, continued
3 courses for the treatment of of medication, scar disappear, and Effect of follow-up visit by telephone half a year does not recur.
Case 5, patient Zhao, female, 2 years old half, the long 1.0cm × 1.5cm × spongy blood vessel of 0.5cm size in chest right side
Tumor, 2 courses for the treatment of of Chinese medicine composition provided using the embodiment of the present invention 2, symptom decline, affected part are restored good, continue medication 3
The course for the treatment of, scar disappear, and Effect of follow-up visit by telephone half a year does not recur.
Described is only presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on should all include within protection scope of the present invention.
Claims (8)
1. a kind of for treating the Chinese medicine composition of infant hemangioma, which is characterized in that the Chinese medicine composition includes following
The substance of parts by weight: 1-5 parts of thallus laminariae, 1-5 parts of seaweed, 1-5 parts of Radix Salviae Miltiorrhizae, 1-5 parts of radix paeoniae rubra, 1-5 parts of Radix Angelicae Sinensis, 1-5 parts of Radix Rehmanniae, radix scrophulariae
1-5 parts, 1-5 parts of turmeric.
2. as described in claim 1 for treating the Chinese medicine composition of infant hemangioma, which is characterized in that the Chinese medicine group
Conjunction object includes the substance of following parts by weight: 3 parts of thallus laminariae, 3 parts of seaweed, and 3 parts of Radix Salviae Miltiorrhizae, 3 parts of radix paeoniae rubra, 3 parts of Radix Angelicae Sinensis, 3 parts of Radix Rehmanniae, radix scrophulariae
3 parts, 3 parts of turmeric.
3. the dosage form of any Chinese medicine composition preparation of claim 1-2, it is characterised in that: it includes claim 1-2
Any Chinese medicine composition and pharmaceutically acceptable carrier, the dosage form include tablet, pulvis, capsule, granule,
Gelling agent, emulsion, cream or spray.
4. a kind of preparation method of the Chinese medicine composition for treating infant hemangioma as described in claim 1-2 is any,
It is characterized by comprising the following steps:
Step 1 weighs the thallus laminariae, seaweed, Radix Salviae Miltiorrhizae, radix paeoniae rubra, Radix Angelicae Sinensis, Radix Rehmanniae, radix scrophulariae and turmeric in proportion respectively, after drying
It crushes；
Step 2, in the resulting herb powder hot water extraction of step 1, obtain the leaching liquor of different Chinese medicines；
Step 3 merges corresponding medicinal plant extraction obtained by step 2, is used to treat infant hemangioma up to described after water boiling concentration
Chinese medicine composition.
5. as claimed in claim 4 for treating the preparation method of the Chinese medicine composition of infant hemangioma, which is characterized in that
In the step 2, extraction hot water additional amount is 5-15 times of inventory；Extraction progress 1 time or more；Extraction temperature is 60-100
℃；Extraction time is each 1h or more.
6. as claimed in claim 4 for treating the preparation method of the Chinese medicine composition of infant hemangioma, which is characterized in that
In the step 3 when water boiling concentration, the honey that add weight number is 1 part is as flavoring agent.
7. as claimed in claim 4 for treating the preparation method of the Chinese medicine composition of infant hemangioma, which is characterized in that
The specific steps of water boiling concentration in the step 3 are as follows: intense fire infusion 20-30 minutes, turn mild fire infusion 30-40 minutes, filtering filter
Liquid, infusion three times, merges filtrate three times repeatedly.
8. as claimed in claim 4 for treating the preparation method of the Chinese medicine composition of infant hemangioma, which is characterized in that
Water boiling concentration is to 100ml in the step 3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811144458.9A CN109045243A (en) | 2018-09-29 | 2018-09-29 | Chinese medicine composition, preparation and preparation method thereof for treating infant hemangioma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811144458.9A CN109045243A (en) | 2018-09-29 | 2018-09-29 | Chinese medicine composition, preparation and preparation method thereof for treating infant hemangioma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109045243A true CN109045243A (en) | 2018-12-21 |
Family
ID=64766650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811144458.9A Pending CN109045243A (en) | 2018-09-29 | 2018-09-29 | Chinese medicine composition, preparation and preparation method thereof for treating infant hemangioma |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109045243A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110464774A (en) * | 2019-09-17 | 2019-11-19 | 河南百年康鑫药业有限公司 | A kind of compound hydrochloric acid Propranolol oral solution for treating infantile hemangioma |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810841A (en) * | 2009-12-11 | 2010-08-25 | 律北平 | Formula of orally-taken Chinese medicament for treating hemangioma |
| CN102631464A (en) * | 2012-05-18 | 2012-08-15 | 许从玉 | Chinese medicinal ointment for treating infantile hemangioma and preparation method thereof |
| CN104984265A (en) * | 2015-08-06 | 2015-10-21 | 宋艳霞 | Traditional Chinese medicine preparation for cutaneous hemangioma and preparation method thereof |
-
2018
- 2018-09-29 CN CN201811144458.9A patent/CN109045243A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810841A (en) * | 2009-12-11 | 2010-08-25 | 律北平 | Formula of orally-taken Chinese medicament for treating hemangioma |
| CN102631464A (en) * | 2012-05-18 | 2012-08-15 | 许从玉 | Chinese medicinal ointment for treating infantile hemangioma and preparation method thereof |
| CN104984265A (en) * | 2015-08-06 | 2015-10-21 | 宋艳霞 | Traditional Chinese medicine preparation for cutaneous hemangioma and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110464774A (en) * | 2019-09-17 | 2019-11-19 | 河南百年康鑫药业有限公司 | A kind of compound hydrochloric acid Propranolol oral solution for treating infantile hemangioma |
| CN110464774B (en) * | 2019-09-17 | 2021-07-20 | 河南百年康鑫药业有限公司 | Compound propranolol hydrochloride oral liquid for treating infantile hemangioma |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104799003A (en) | Compound feed for 10-30-day-old piglets and preparing method thereof | |
| CN103768531B (en) | Chinese medicine composition being used for the treatment of rheumatoid arthritis and preparation method thereof | |
| CN102178908B (en) | Preparation method of traditional Chinese medicine for treating over fatigue cold injury | |
| CN103656365B (en) | A kind of Chinese medicine for the treatment of the hyperthyroidism of deficiency of YIN of both the heart and liver pattern of syndrome | |
| CN109045243A (en) | Chinese medicine composition, preparation and preparation method thereof for treating infant hemangioma | |
| CN105214010A (en) | A kind of Chinese medicine preparation for the treatment of chronic cholecystitis | |
| CN102824622B (en) | Preparation method of traditional Chinese medicine lotion for treating closed fracture with syndrome of palpitation | |
| CN104857454B (en) | A kind of traditional Chinese herbal decoction for treating Severe Acute Pancreatitis SAP | |
| CN104069463B (en) | A kind of Chinese drugs agentia for treating gynaecologic metrorrhagia | |
| CN102793904A (en) | Preparation method for traditional Chinese medicine lotion for treatment of confusing-type closed fracture | |
| CN104069305A (en) | Traditional Chinese medicine composition for treating chronic pelvic inflammation and preparation method thereof | |
| CN103735676B (en) | A kind of compound Chinese medicinal preparation for the treatment of traumatic injury and its preparation method and application | |
| CN114886959B (en) | Pharmaceutical composition, preparation and application thereof | |
| CN104825888B (en) | A kind of Chinese medicine composition for treating obstinate asomnia and preparation method thereof | |
| CN104027789A (en) | Traditional Chinese medicine composition for treating cold retardation type jaundice of newborn babies and preparing method thereof | |
| CN104825856A (en) | Traditional Chinese medicinal composition for treating facial paralysis | |
| CN108042768A (en) | A kind of Chinese medicine composition for treating lower limb vein thrombus and preparation method thereof | |
| CN108992655A (en) | A kind of anti-inflammatory is dispelled swollen Chinese medicine and preparation method thereof | |
| CN102824621B (en) | Method for preparing Chinese medicinal lotion for treating over-fatigue type closed fracture | |
| CN103301372A (en) | Preparation method of umbilicus dressing agent for treating post-operation prostate stress urinary incontinence | |
| CN102824546A (en) | Method for preparing Chinese medicinal lotion for treating closed fracture due to deficiency of kidney yin | |
| CN110339235A (en) | A kind of Chinese medicine composition for treating hemorrhoid | |
| CN106822557A (en) | It is a kind of to treat medicine of hemorrhoid and preparation method thereof | |
| CN108295210A (en) | A kind of Chinese medicine preparation for treating refractory skin | |
| CN108042722A (en) | A kind of Chinese medicine for treating cloudy closed form apoplexy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181221 |
|
| RJ01 | Rejection of invention patent application after publication |