CN104825888B - A kind of Chinese medicine composition for treating obstinate asomnia and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of Chinese medicine composition for treating obstinate asomnia and preparation method thereof, belong to the field of Chinese medicines.Said composition, it is made up of each bulk drug of following parts by weight：15 25 parts of cultivated land, 7 12 parts of donkey-hide gelatin, 6 10 parts of the coptis, 58 parts of radix scutellariae, 35 parts of Chinese cassia tree, 10 20 parts of Semen Ziziphi Spinosae (parched), 8 15 parts of cortex albiziae, 8 10 parts of radix bupleuri, 6 10 parts of Fructus Aurantii, 6 10 parts of Tabasheer, 8 10 parts of stiff silkworm, 10 20 parts of vinegar turtle shell, 10 20 parts of vinegar stir-baked PLASTRUM TESTUDINIS before treated with Vinegar, 10 20 parts of calcined oyster shell, 6 15 parts of cudrania root.Effect soothing liver-qi stagnation is calmed the nerves, work(of the mutually fiery, reducing phlegm and resolving masses by the stasis of blood drops in nourishing kidney-yin, suitable for the treatment of the intractable aypnia of the various card types such as deficiency of kidney-YIN, the damp and hot, combination of phlegm and heat of liver depression., safe to use, few side effects evident in efficacy to intractable aypnia patient, more simple western medical treatment are had a clear superiority, and clinic is promoted.

Description

A kind of Chinese medicine composition for treating obstinate asomnia and preparation method thereof

Technical field

The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of Chinese medicine composition for treating obstinate asomnia and its Preparation method.

Background technology

Insomnia is that Depth of sleep is inadequate and is unable to dispelling fatigue, regains one's strength with energy be main with length of one's sleep deficiency The disease of feature.Course of disease half a year above person is intractable aypnia.Intractable aypnia mainly due to insomniac fall asleep before to fall asleep, Sleep quality, sleep when sound interference, early awakening phenomena such as allergy emotional reactions and excessive anxiety, intense strain and trigger 's.In the classification of insomnia, intractable aypnia is a kind of common disease, and this course of disease length is often touching refractory, thus causes essence to patient Refreshing and sensual considerable distress；And compared with insomnia secondary, its treatment difficulty with it is bigger.Intractable aypnia often by Cause in psychological factor, clinic be mainly shown as difficulty falling asleep and maintain dyscoimesis, in the daytime tired out sense, night more think to enter as early as possible Sleep and more have difficulty in going to sleep, precipitate psychosocial conflict, produce nervous anxiety, emotional lability, undue worries, feel that pain more causes to have a sleepless night, Form vicious circle.With the quickening of people's rhythm of life, this sick incidence of disease is in rising trend, drastically influence the work of patient Work and quality of life.For Western medicine more using calm, hypnosis and anxiolytic treatment, therapeutic effect is bad, and can not be long-term use of. Compared with Western medicine, treatment of the traditional Chinese medicine to intractable aypnia has the advantages of curative effect is stable, and toxic side effect is small.In insomnia especially In the treatment of intractable aypnia, traditional Chinese medicine plays an important role.

The content of the invention

The invention provides a kind of positive effect, efficient high, the Chinese medicine group for the treatment obstinate asomnia having no side effect Compound and preparation method thereof.

The present invention is achieved by the following technical solutions：

A kind of Chinese medicine composition for treating obstinate asomnia, it is characterised in that by each bulk drug group of following parts by weight Into：Cultivated land 15-25 parts, donkey-hide gelatin 7-12 parts, coptis 6-10 parts, radix scutellariae 5-8 parts, Chinese cassia tree 3-5 parts, Semen Ziziphi Spinosae (parched) 10-20 parts, silk tree Skin 8-15 parts, radix bupleuri 8-10 parts, Fructus Aurantii 6-10 parts, Tabasheer 6-10 parts, stiff silkworm 8-10 parts, vinegar turtle shell 10-20 parts, vinegar stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 10-20 parts, calcined oyster shell 10-20 parts, cudrania root 6-15 parts.

Preferably, the parts by weight of each bulk drug are：20 parts of cultivated land, 10 parts of donkey-hide gelatin, 8 parts of the coptis, 8 parts of radix scutellariae, 4 parts of Chinese cassia tree, 15 parts of Semen Ziziphi Spinosae (parched), 12 parts of cortex albiziae, 8 parts of radix bupleuri, 8 parts of Fructus Aurantii, 8 parts of Tabasheer, 9 parts of stiff silkworm, 15 parts of vinegar turtle shell, vinegar stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 15 parts, 15 parts of calcined oyster shell, 10 parts of cudrania root.

Medicine activity component of the present invention can add various auxiliary materials required when preparing different dosage forms, such as disintegrant, profit Lubrication prescription, binder etc., any suitable clinical preparation is prepared into the method for Chinese medicinal of routine, such as can be glue Wafer, pill, powder, granule, tablet, oral liquid or pill etc., preferably capsule or granule.

A kind of preparation method of Chinese medicine composition of the present invention：Each bulk drug is weighed by the parts by weight；By each raw material medicinal powder It is broken, sieving, the auxiliary material or excipients needed for preparations shaping are added, is prepared into capsule, tablet or pill.

Preferably, the preparation method of the Chinese medicine composition of the treatment obstinate asomnia, it is characterised in that including following Step：

(1) each bulk drug is weighed by the parts by weight；

(2) cultivated land, radix bupleuri, Fructus Aurantii, cortex albiziae, stiff silkworm, vinegar turtle shell, vinegar stir-baked PLASTRUM TESTUDINIS before treated with Vinegar, calcined oyster shell, cudrania root are extracted with water Twice, merge aqueous, be concentrated under reduced pressure, concentrate is spray-dried, it is standby；

(3) coptis, radix scutellariae, Chinese cassia tree and new Semen Ziziphi Spinosae (parched) are extracted twice with 40-80% ethanol, ethanol extract is reclaimed After ethanol, spray drying is standby；

(4) it is well mixed after crushing donkey-hide gelatin, Tabasheer with the product obtained by step (2) and (3), adds pharmaceutical preparation Intermediate formulations are made in auxiliary materials and mixing, then finished dosage form is made through preparations shaping technique.

Present invention also offers application of the described Chinese medicine composition in intractable aypnia disease drug is prepared.

The compatibility foundation of Chinese medicine composition of the present invention：

The most course of disease of intractable aypnia patient is longer, is chronically at nervous state, and mental burden is heavy, therefore mood presses down It is strongly fragrant, the catharsis function of liver is influenceed, causes stagnation of liver qi.Intractable aypnia is more by dysfunction of SHAO YANG, functional activities of the body fluid imbalance, the obstruction of the circulation of vital energy Heat, liquid are polymerized to phlegm, caused by stagnant few positive three Jiao of phlegm (wet) thermal resistance.Few sun three is burnt to lift out people's passage for functional activities of the body fluid, functional activities of the body fluid circulation, depends on In courage hair tonic, temper transport, lung qi a surname's drop.If the heresy of the diseases caused by external factors six external factors which cause diseases, dysfunction of SHAO YANG, influenceing courage and not relaxing, spleen fortune Obstacle；Or the change of internal damage by the excessive seven emotions, three burnt functional activities of the body fluid imbalances are influenceed, at first based on damp and hot, the damp and hot disease that decocts is long, causes the deficiency of Yin, after And moisture coagulates phlegm, last phlegm wet enters blood and enters network；Liver Channel is blocked by phlegm, wet, hemostasis, hinders clear sun to rise, turbid yin declines, negative and positive liter Jiang Churenzhi roads are hindered, and cause Liver Channel stasis, imbalance of yin and yang, so as to cause the moon not enter the sleep-disorder such as sun.Dogwood fruit in side, Ah Glue nourishing Yin and clearing heat, the in love product of turtle shell, tortoiseshell flesh and blood, both by the heresy of the moon point, essence and blood is nourished again；Close oyster, stiff silkworm with dredging collateral, search Evil, dissipating bind；The coptis, Chinese cassia tree drop mutually fire, spina date seed, cortex albiziae resolving stagnation for tranquilization, hold back gas and feel at ease kidney, coordination between the heart and kidney fire is from flat；Radix bupleuri, Radix scutellariae, the dried immature fruit of citron orange, India yellow liver and gallbladder damp-heat, soothing liver-qi stagnation, clearing heat and eliminating phlegm, clearing gallbladder and stomach；The kind logical liver and gall warp of cudrania root, wind-dispelling profit It is wet, invigorate blood circulation；All medicines share giving consideration to both the incidental and fundamental, train lower Jiao, it is burnt in dredging, hold back the part of the body cavity above the diaphragm housing the heart and lungs, make lifting in order, negative and positive reconcile, long memorial altogether Work(of the mutually fiery, reducing phlegm and resolving masses by the stasis of blood drops in liver resolving stagnation for tranquilization, nourishing kidney-yin, each suitable for deficiency of kidney-YIN, the damp and hot, combination of phlegm and heat of liver depression etc. The treatment of the intractable aypnia of kind card type.Research shows, evident in efficacy to intractable aypnia patient, safe to use, the secondary work of we With less, more simple western medical treatment is had a clear superiority, and clinic is promoted.

The analysis of every medicine in side：

Cultivated land：It is sweet, slightly warm in nature；Return liver and kidney channel；Function is with curing mainly：Enrich blood enriching yin, beneficial to spirit and marrow.For blood deficiency chlorosis, Palpitation and severe palpitation, irregular menstruation, metrostaxis, the deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, osteopyrexia and fever, night sweat seminal emission, Heat Diabetes, dizziness, Tinnitus, chin hair are early white.《Pearl sac》：Big empty deficiency of enriching blood, promoting blood circulation, benefiting energy.《Cure mainly secret want》Cloud：It is with having five：Kidney-nourishing Water is Kidney-Yin one, and postpartum qi and blood two, goes navel abdomen shoot three, and sun four is moved back in yin-nourishing, strengthens the source five of water.《Detailed outline》：Fill out Marrow, long muscle, promoting vital essence and blood genernation.Tonifying five zang organs internal injury deficiency, promoting blood circulation, sharp knowledge, black beard and hair, man's general debility, during woman hinders Threatened abortion, irregular menorrhea, tire produce all kinds of diseases and ailments.《The new compilation of materia medica》：Kidney nourishing water, packing marrow, sharp blood vessels, help is Kidney-Yin, hearing-improing and eyesight improving, black Send out palpus black.And can tonifying spleen-yin, only chronic diarrhea.Internal lesion caused by overexertion wandering arthritis, yin deficiency heating are controlled, dry cough phlegm is coughed, and dyspnea with shortness of breath, emptiness of the stomach feels hungry, Acne demonstrate,proves no purulence of having a guilty conscience, and shin stock is ached after being ill, and postpartum navel abdomen suddenly aches, sense card yin deficiency, lossless constipation, all kinds of dynamic blood, all liver kidney yins Thanks to, deficient all kinds of diseases and ailments, to strengthen the main ingredient of water.

Cortex albiziae：It is mild-natured, it is sweet.The thoughts of returning home, liver, lung channel.Major function：Resolving stagnation for tranquilization, activating blood circulation and reducing swelling.For the mind not Peace, melancholy Sjogren syndrome, lung carbuncle sore swells, the pain of injury caused by falling and tumbling.《This warp》：Main five viscera settling, and will, make us happy carefree.《Solar corona Sub- book on Chinese herbal medicine》：Soft extracts, subduing inflammation and continuous muscles and bones.《Detailed outline》：And blood, subside a swelling, analgesic.

The coptis：Bitter, it is cold in nature.The thoughts of returning home, spleen, stomach, liver, courage, large intestine channel.Major function：Heat-clearing and damp-drying drug, purging intense heat and detonicating.With In damp and hot feeling of fullness, acid regurgitation is vomitted, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, blood-head tells nosebleed, hot eyes, is had a toothache, Quench one's thirst, carbuncle swells furunculosis；Eczema, wet sore are controlled outside, duct is suppurated.《This warp》：Main hot gas mesh pain, corner of the eyes wound weep, and improving eyesight, intestines debate stomachache Diarrhea, swell and ache in married woman's the moon.《Essentials of Materia Medica》：Control ulcer sore scabies, wine poison, the skin infections of newborn infants.Except infantile malnutrition due to digestive disturbances or intestinalparasites, ascarid is killed.

Donkey-hide gelatin：It is sweet, it is mild-natured.Return lung, liver and kidney channel.Major function：Enrich blood enriching yin, moisturize, stop blooding.For blood deficiency chlorosis, Dizziness palpitaition, impotence weakness, dysphoria and insomnia, endogenous deficient wind, xeropulmonary cough, overstrain cough spitting of blood, haematemesis hematuria, uterine bleeding of having blood in stool, gestation Threatened abortion.《This warp》：Collapsed in main trusted subordinate, the extremely voluminous symptoms like malaria of labor, waist stomachache, painful limbs, blood under woman.It is antiabortive.Long term usage QI invigorating. 《Haigoushen》：Main hard muscles and bones, QI invigorating stop dysentery.《A thousand pieces of gold food therapy》：Control strong wind.《Japan hanako materia medica》：Control a wind cutting, and profuse nasal bleeding, Under haematemesis, intestines wind, bloody flux and metrorrhagia band.《Detailed outline is picked up any lost article from the road》：Lumbago caused by internal damage is controlled, strongly stretches muscle, adds essence and reinforces the kidney.

Spina date seed：It is mild-natured, it is sweet, sour.Return liver, courage, the heart channel of Hang-Shaoyin.Major function：Tonifying liver, calming heart, arrest sweating, promote the production of body fluid.For void Tired egersis, horrified to much dream, body void hidrosis, injury thirst.《This warp》：Main trusted subordinate's fever and chills, heresy knot gas gather, painful limbs, arthritis with fixed pain caused by dampness. 《Do not record》：Master is vexatious to sleep, and pain, blood turn to let out long, abnormal sweating polydipsia, bowl spares, beneficial irritability, hard muscles and bones, helps cloudy gas, make us navel up and down Fertilizer is strong.《Haigoushen》：Cage bar bone wind, fry end and take it as soup.Wang Haogu：Milk-livered egersis is controlled, is trembled with fear, fries clothes；Somnolence due to gallbladder-excess is controlled, heat , it is raw to use.《Collected statements on the herbal foundation》：Hold back gas to calm the nerves, flourish muscle supports marrow, and stomach fortune spleen.《Book on Chinese herbal medicine is new again》：Soothing the liver qi-regulating, moistens the lung and nourish yin, temperature Middle dampness removing, gas hidroschesis is held back, beneficial will is breathed out surely, hearing-improing and eyesight improving.

Calcined oyster shell：It is salty, it is slightly cold.Return liver, courage, kidney channel.Effect：Restrain astringent or styptic treatment for spontaneous sweating, relieving haperacidity analgesic, transquilization with heavy material, softening and resolving hard mass. With enriching yin, blood-nourishing, tonifying five zang organs, invigorate blood circulation, fill flesh and other effects.《This warp》：Main typhoid fever fever and chills, a kind of malaria is voluminous, frightened gas of being enraged, except inflexible Slow mouse fistula, woman are red white with.The strong joint of long term usage.《Do not record》：Except heat is stayed in joint Rong Wei, abnormal heat goes to carry out indefinite, dysphoria；Only Sweat, it is pained depressed, quench the thirst, except old blood.Essence, larynx numbness, cough, the lower ruffian heat of the heart side of body are let out in puckery intestine and small intestine, only stool and urine, treatment.《Extra large medicine sheet Grass》：Main man's seminal emission, the weary damage of consumptive disease, kidney tonifying healthy tendency, only night sweat, goes dysphoria with smothery sensation, and cure the wound fever and chills phlegm, can take a tonic or nourishing food to build up one's health and calm the nerves, control child and shy Epilepsy.《Pearl sac》：Soft mass in the abdomen.Control again under band, a kind of malaria, sore swells, be the agent of softening hard masses inducing astrigency.《Detailed outline》：Resolving phlegm and softening hard masses, heat-clearing remove Wet, only bitterly, under dysentery, reddish and whitish turbid urine, the hernia that disappears lump in the abdomen accumulates block, goitre disease tuberculosis to heart temper.

Vinegar processs tortoise version：For the crust of Testudinidae animal tortoise（Predominantly plastron）Vinegar process processed product.Taste is salty sweet, mild-natured.Enter Liver and kidney channel.Major function：Enriching yin, checking exuberance of yang, kidney tonifying, strong bone.The deficiency of the kidney yin is controlled, hectic fever due to yin labor heat, is spitted blood, bleeding from five sense organs or subcutaneous tissue, chronic cough, seminal emission, Uterine bleeding, with, pain in the back, the atrophic debility of bones, wind formation from yin deficiency, protracted dysentery, chronic malaria, hemorrhoid, non-closure of fontanels jin infants.《This warp》：Main whitish metrorrhagia, break Abdominal mass , Jie malarias, five hemorrhoid, the erosion of vulva, arthritis with fixed pain caused by dampness, heaviness of limbs is weak, and children's fontanel does not conform to.《Do not record》：Main head sore difficulty is dry, woman's erosion of vulva, and frightened Anger gas, pain in the chest and abdomen, can not stand long, fever and chills in bone, typhoid fever labor is answered, or human body fever and chills are intended to extremely, good to make soup, QI invigorating money intelligence, is also made People can eat.Zhu Zhenheng：Tonifying yin, main deficiency of YIN-blood, hemostasis is removed, dysentery of stopping blooding, continuous muscles and bones, control overstrain, weakness of limbs.《Book on Chinese herbal medicine covers Bamboo fish trap》：Special tonifying yin declines, and is apt to nourshing kidney damage.《Detailed outline》：Control waist pin to ache, bushing kidney, beneficial large intestine, only protracted dysentery is let out long, and main difficult labour, disappear carbuncle Swollen, ashing applies ulcer on the shank.《Medical center seal character will》：Hectic fever due to yin labor heat is controlled, is spitted blood, bleeding from five sense organs or subcutaneous tissue, intestines wind hemorrhoid blood, the disease of YinXuXueRe.

Radix bupleuri：Bitter, cold nature.Return liver, gallbladder channel.Major function：It is soothing the liver in inducing diaphoresis, rising Yang.For cold, fever, Fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation, sub-official prolapses, prolapse of the anus.《This warp》：Gas is tied in main trusted subordinate's stomach, diet accumulation, is trembled with fear Heat evil gas, pushes away Chen Zhixin.《Haigoushen》：Zhi Relao restless bone pains, hot gas, shoulder and back ache, smooth vim and vigour are declared, it is tired thin thin；Under master Gas is helped digestion, and heat is not understood inside and outside disease when main, singly boils clothes.《Japan hanako materia medica》：General debility is mended, relieving restlessness is only frightened, and benefiting energy, dissolving phlegm stops Cough, embellish lung, add smart mends marrow, day row temperature disease is fanatical weary exhausted, and chest side of body gas is expired, forgetful.《Medicine origin》：Except consumptive disease dysphoria with smothery sensation, dismiss Flesh heat, removes morning hectic fever.

Radix scutellariae：Bitter, it is cold in nature.Return lung, courage, spleen, large intestine, small intestinl channel.Major function：Heat-clearing and damp-drying drug, purging intense heat and detonicating, only Blood, it is antiabortive.For damp-warm syndrome, heat temperature evil of vomitting uncomfortable in chest, damp and hot feeling of fullness, rush down dysentery, jaundice, cough with lung heat, hyperpyrexia polydipsia, blood-head tells nosebleed, Carbuncle sore tumefacting virus, fetal irritability.《This warp》：Main all hot jaundice, intestines Bleach, let out profit, relieve oedema or abdominal distension through diuresis or purgation, and lower blood closes,（Control）Malignant sore, subcutaneous ulcer erosion, fiery ulcer. 《Do not record》：" phlegm heat is treated, pathogenic heat in the stomach, small eilema, disappear paddy, and sharp small intestine, woman's blood closes, the lower blood of leaching dew, abdominal pain in children.《The property of medicine By》：Heat toxin can be controlled, hectic fever due to yin, fevers and chills alternate, stomach is unfavorable, breaks and stops up gas, controls five leaching, makes us a surname freely, goes to joint unhappy, antipyretic thirsty, Hot Fu Zhong Xu pains are controlled, trusted subordinate's heavily fortified point is swollen.《The southern regions of the Yunnan Province book on Chinese herbal medicine》：" up purte the white, it is descending to rush down bladder fire,（Control）Man five is drenched, Nv Zibao Collapse, menstruation regulating heat-clearing, tire has burning hot uneasiness, clear tire heat, except the six channels excess fire real heat."

Fructus Aurantii：It is bitter, pungent, sour, it is warm-natured.Returns spleen, stomach.Major function：Regulating the flow of QI to ease the stomach, the stagnant dissipate-swelling of row.For chest side of body gas It is stagnant, turgor pain, accumulation of food in the stomach and intes tine due to indigestion, stop in phlegm and retained fluid；Gastroptosis, prolapse of the anus, sub-official prolapses.《Haigoushen》:Control rubella all over, in flesh such as Numb beans, which are disliked, itches, main intestines wind haemorrhoids, stagnation of vital energy in the chest and abdomen, the two swollen void of the side of body, closes diaphragm congestion.《Japan hanako materia medica》:Spleen benefiting and stimulating the appetite, the five internal organs are adjusted, Lower gas, preventing or arresting vomiting is inverse, dissolving phlegm.Gastric disorder causing nausea is controlled, cholera rush down dysentery, is helped digestion, breaks crux Xuan addictions, five types of dysphagia, except wind improving eyesight and lung qi oedema, profit Intestine and small intestine, skin are itched.Swollen can process of hemorrhoid is pressed.《Pearl sac》:Relieving stagnant Qi, let out gas unfavorable in lung.《Medicine origin》:《Cure mainly secret formula》 Cloud, hardness in the epigastrium ruffian is broken, sharp gas in the heart, resolving sputum, is helped digestion.

Stiff silkworm：Property is pungent salty, and taste is put down.Major function：Expel endogenous wind to relieve convulsion, reducing phlegm and resolving masses.Control apoplectic aphasia, frightened epilepsy, intermittent headache, larynx Wind.Larynx numbness, scrofula tuberculosis.Wind sore urticaris, erysipelas, mastitis.《This warp》：The main pediatric epilepsy scared morbid night crying of babies, go three worms, Mie Hei über, man The cloudy ulcer disease of son.《Japan hanako materia medica》：Apoplectic aphasia, and a wind cutting disease are controlled, convulsive seizures induced by terror in children, man's pruritus vulvae pain, woman is with.《Guiding principle Mesh》：Scattered wind phlegm tuberculosis, scrofula, intermittent headache, wind worm dentalgia, skin wind sore, erysipelas are had an itch, and Tan Nve Disorder knots, married woman's alactation, are collapsed In lower blood, children's infantile malnutrition due to digestive disturbances or intestinalparasites erosion squama body, all metal-inflicted wounds, malignant boil swells wind hemorrhoid.《Beautiful Chinese catalpa medicine solution》：Active to stimulate the menstrual flow, wind dispelling opens numbness.Control headache chest Numbness, lockjaw are had a toothache, urticaria wind scabies；Burning grinds wine clothes, the broken top of the carbuncle that can burst, controls blood strangury metrorrhagia again.

Vinegar turtle shell：Taste is salty, cold nature.Return liver and kidney channel.Major function：Nourishing and suppressing Yang, softening and resolving hard mass, bring down a fever except steaming.For Fever due to yin deficiency, the hot hectic fever due to yin of labor, endogenous deficient wind, Amenorrhea , wei lumps in the abdomen, chronic malaria malaria are female.《This warp》：Main trusted subordinate's abdominal mass heavily fortified point product, fever and chills, go Ruffian, polyp, the erosion of vulva, hemorrhoid（Core）, dislike meat.《Do not record》：Treat a kind of malaria, blood lump in the abdomen, pain in the back, the lower heavily fortified point of children's side of body.《Haigoushen》：Home food, Disease block, Xuan addictions gas, cold lump in the abdomen, labor are thin, lower gas, and except bone heat, labor is hot between joint, solid to be jammed.Married woman is controlled to leak down the thin thin person of the five colors. 《Japan hanako materia medica》：Vim and vigour are gone, break crux, extravesated blood, induced abortion, the sore swells that disappear simultaneously flutter damage hemostasis, malaria, acute appendicitis.《Amplification on Materia Medica is mended Lose》：Tonifying yin tonifying Qi.《Elementary Medicine》：Main malaria with general debility, old malaria, woman's Amenorrhea, infantile dysentery.《Jiangxi Chinese medicine》：Control osteomalacia.

Cudrania root：Lightly seasoned slight bitter, it is cool in nature.Major function：Expelling wind and removing dampness, invigorate blood circulation.Control pain in rheumatoid joints, jaundice, Stranguria with turbid discharge, tympanites due to parasitosis, amenorrhoea, internal lesion caused by overexertion hemoptysis, traumatic injury, furunculosis carbuncle swells.《The sward property of medicine is standby will》：Wine top is controlled, disappear tympanites due to parasitosis；Infusing drugs in wine is dispelled Wind.《Book on Chinese herbal medicine asks former》：Strengthen the bone, invigorate blood circulation, manage bruise.《Nanning City's medicine will》：Blood stimulates the menstrual flow, and controls stranguria with turbid discharge, removes many years ago stasis of blood product, knot Stone.《Fujian east book on Chinese herbal medicine》：Invigorating spleen and reinforcing stomach, relaxing tendons and activating collaterals, wind-damp dispelling, remove hemostasis.Pain in the back, arthralgia are controlled, consumptive disease is yellow swollen, insufficiency of the spleen to let out Rush down.Guangzhou army《Conventional Chinese herbal medicine handbook》：Cool blood dissipates the stasis of blood.Controlling through closing.《Guangxi practicality Chinese herbal medicine newly selects》：Heat clearing and blood circulation promoting, only Cough eliminating the phlegm, control internal lesion caused by overexertion hemoptysis.《Fujian Chinese herbal medicine》：Clearing heat and promoting diuresis.Damp-heat arthralgia, furunculosis carbuncle swells.

Chinese cassia tree：Acrid flavour, sweet, extremely hot in nature.Return kidney, spleen, the heart, Liver Channel.Major function：Mends fire supporing yang, let the fire back to its origin, cold dispelling stop Bitterly, invigorate blood circulation.Told for impotence, Gong Leng, waist and knee crymodynia, deficiency of the kidney and dyspnea, dizziness due to yang deficiency, hot eyes pharyngalgia, trusted subordinate's crymodynia, the cold of insufficiency type Rush down, cold hernia, run quickly globefish, Amenorrhea, dysmenorrhoea.《This warp》：Your Majesty's gas cough is inverse, and knot gas larynx numbness tells suction, sharp joint, tonifying middle-Jiao and Qi.《Do not record》： Master is pained, coerces wind, hypochondriac pain, warm muscle, promotes blood circulation, and is only tired of, perspires.Main middle benefit gas, benefitting liver and lung gas, trusted subordinate's fever and chills, cold disease, choleraic myospasm, Headache, pain in the back, only saliva, cough , Bi Weng：It can have an abortion, hard joint, promoting blood circulation, manage and dredge deficiency；A surname leads hundred medicines, without being feared.《Solar corona Sub- book on Chinese herbal medicine》：All general mood are controlled, mend general debility, leads to nine orifices, sharp joint, strengthening the essence, improving eyesight, warms up waist and knee, break Xuan addiction abdominal mass, dispersing blood stasis Blood, control wandering arthritis joint contracture, continuous muscles and bones, myogenic meat.《Medicine origin》：Lower burnt deficiency is mended, controls that heavy cold shoulder is cold and exterior deficiency spontaneous perspiration.King Good Gu：Mend gate of vitality's deficiency, boosting source of fire for eliminating abundance of yin.

Tabasheer：It is sweet, it is cold in nature.The thoughts of returning home, Liver Channel.Major function：Heat phlegm, cool heart arresting convulsion.For pyreticosis coma, in Wind phlegm fan, the hot frightened epilepsy of children's phlegm, twitch, the morbid night crying of babies.《Solar corona》：Control heap soil or fertilizer over and around the roots of apoplexy phlegm, acute aphasia in silence, convulsive seizures induced by terror in children and epilepsy phlegm. 《Kaibao Bencao》：Main child convulsion day is hung, relieving palpitation improving eyesight, goes all wind-heat, is treated metal-inflicted wound hemostasis, is nourished the five internal organs.《Compendium of Materia Medica》：Gas Taste function and bamboo juice are same, and without cold sliding property.《Collected statements on the herbal foundation》Carry：Tabasheer, slit phlegm profit key, the medicine of tranquillizing the mind by relieving convulsion.Li Shi Say, its smell function is similar with bamboo juice.Bamboo juice speed, leads directly to channels and collaterals, and has the work(of cold cunning；Tabasheer delays, and empties solution Heat, and there more have arresting convulsion to calm the nerves to be wonderful.Therefore preceding Gu is controlled child convulsion day and hung, morbid night crying of babies egersis, the disobedient dysentery malaria of visitor, and cold phlegm closes, and generates heat Shortness of breath, enter and embrace imperial ball, Zhi Ying sections shy phlegm and want agent.Such as adult's apoplexy, aphonia in silence, enters in wind phlegm medicine, also proved effective repeatly.

Embodiment

With reference to embodiment, the present invention is further described.

Embodiment 1：The preparation of capsule

(1) each raw material is weighed by following weight：Cultivated land 250g, donkey-hide gelatin 120g, coptis 100g, the g of radix scutellariae 80, Chinese cassia tree 50 G, the g of Semen Ziziphi Spinosae (parched) 200, the g of cortex albiziae 150, the g of radix bupleuri 100, the g of Fructus Aurantii 100, the g of Tabasheer 100, the g of stiff silkworm 100, vinegar turtle shell 200 g, the g of vinegar stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 200, the g of calcined oyster shell 200, wear out 150 g.

(2) by cultivated land, radix bupleuri, Fructus Aurantii, cortex albiziae, stiff silkworm, vinegar turtle shell, vinegar stir-baked PLASTRUM TESTUDINIS before treated with Vinegar, calcined oyster shell, cudrania root water extraction Take twice, add 12 times of weight of water for the first time, decoct 2 hours, second plus 8 times of weight of water, decoct 1 hour；Decoction liquor is merged, Filtration, it is 1.10-1.15 (55 DEG C) clear cream that filtrate, which is concentrated into relative density, spray drying, standby；

(4) by the coptis, radix scutellariae, Chinese cassia tree and new Semen Ziziphi Spinosae (parched) are secondary with 10 times of amount 80% ethanol extractions, 1 hour every time, carry Liquid is taken to reclaim ethanol, spray drying is standby；

(5) it is well mixed, adds appropriate with the product obtained by step (2) and (3) after crushing donkey-hide gelatin, Tabasheer Lactose, mix, dry-pressing is into particle, and filling into capsule 1000, every fills 0.5g, produces.

Embodiment 2：The preparation of capsule

Composition：Cultivated land 375g, donkey-hide gelatin 180g, coptis 150g, radix scutellariae 120g, Chinese cassia tree 75g, the g of Semen Ziziphi Spinosae (parched) 300, conjunction The joyous g of skin 225, the g of radix bupleuri 150, the g of Fructus Aurantii 150, the g of Tabasheer 150, the g of stiff silkworm 150, the g of vinegar turtle shell 300, vinegar stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 300 G, the g of calcined oyster shell 300, wear out 225g.

Preparation technology：

(1) coptis, radix scutellariae, Chinese cassia tree and the amount extraction 2 times of 10 times of 70% ethanol of new Semen Ziziphi Spinosae (parched), 1.5 hours every time, filtration, After filtrate recycling ethanol, relative density 1.08~1.10 is concentrated into（60℃）, it is standby to be spray-dried obtained fine powder；

(2) by cultivated land, radix bupleuri, Fructus Aurantii, cortex albiziae, stiff silkworm, vinegar turtle shell, vinegar stir-baked PLASTRUM TESTUDINIS before treated with Vinegar, calcined oyster shell, cudrania root water extraction Take twice plus 8 times of amounts of water are extracted 2 times, 1 hour every time, filtration, filtrate was concentrated into relative density 1.08~1.10（60℃）, spraying It is standby to dry obtained fine powder；

(3) alcohol extract spray drying fine powder, Aqueous extracts spray drying fine powder, donkey-hide gelatin and Tabasheer comminuted powder is taken to be made after mixing Grain, it is filling, capsule 1500 is made, every dress 0.5g, produces.

Embodiment 3：The preparation of pill

Each bulk drug is weighed by following weight：Cultivated land 150g, donkey-hide gelatin 70g, coptis 60g, radix scutellariae 50g, Chinese cassia tree 30g, stir-fry acid Jujube kernel 100g, cortex albiziae 80g, radix bupleuri 80g, Fructus Aurantii 60g, Tabasheer 60g, stiff silkworm 80g, vinegar turtle shell 100g, vinegar stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 100g, Calcined oyster shell 100g, cudrania root 60g.After above-mentioned each bulk drug is crushed, cross 100 mesh sieves, be produced in conventional fashion into the water-bindered pill or Big honeyed bolus, is produced.

Embodiment 4：The preparation of granule

(1) each raw material is weighed by following weight：Each raw material is weighed by following weight：Cultivated land 250g, donkey-hide gelatin 120g, the coptis 100g, the g of radix scutellariae 80, the g of Chinese cassia tree 50, the g of Semen Ziziphi Spinosae (parched) 200, the g of cortex albiziae 150, the g of radix bupleuri 100, the g of Fructus Aurantii 100, Tabasheer 100 g, the g of stiff silkworm 100, the g of vinegar turtle shell 200, the g of vinegar stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 200, the g of calcined oyster shell 200, wear out 150 g.

(2) coptis, radix scutellariae, Chinese cassia tree and new Semen Ziziphi Spinosae (parched) add the amount extraction 2 times of 10 times of 50% ethanol, 2 hours every time, filter, After filtrate recycling ethanol, relative density 1.08~1.10 is concentrated into（60℃）, it is standby to be spray-dried obtained fine powder；

(3) by cultivated land, radix bupleuri, Fructus Aurantii, cortex albiziae, stiff silkworm, vinegar turtle shell, vinegar stir-baked PLASTRUM TESTUDINIS before treated with Vinegar, calcined oyster shell, cudrania root water extraction Take twice plus 12 times of amounts of water are extracted 2 times, 1 hour every time, filtration, filtrate was concentrated into relative density 1.08~1.10（60℃）, spray It is standby that mist dries obtained fine powder；

(4) alcohol extract spray drying fine powder, Aqueous extracts spray drying fine powder, donkey-hide gelatin and Tabasheer is taken to crush microwave sterilization powder After mixing, soluble starch is added, sucrose, is mixed, dried, crush, add appropriate amount of ethanol that particle is made, dry, whole grain, packing, Produce.

Embodiment 5：Clinical research is tested

First, clinical data

1st, general information：

1.1 case sources

In January, 2010 is selected in December, 2014 Hospital Attached to Shandong Chinese Medical Univ. out-patient 104 Example, uses random digits table with 1：1 ratio is randomly divided into treatment group and each 52 of control group.Wherein, treatment group female 31 Example, man 21；Year at age 21~63 (45.8 ± 10.2)；Individual month of the course of disease 13~48 (22.6 ± 8.5)；Symptom score 20~ 40 (26.7 ± 3.3) point.Control group female 29, man 23；Year at age 19~65 (46.8 ± 10.5)；The course of disease 12~48 (20.6 ± 9.7) individual month；Symptom score 19~40 (26.6 ± 3.0) point.Two groups of patients are in sex, age, the course of disease, the state of an illness Etc. general information through statistical analysis there was no significant difference (P>0.05), there is comparativity.

2nd, diagnostic criteria：

Write with reference to WHO《Spirit is classified with behavior disorder（ICD-10)》To the diagnostic criteria of nonorganic insomnia. 1. main suit's difficulty falling asleep, or be difficult to maintain sleep, or poor sleeping quality；Sleep disordered at least occur 3 times and to hold weekly 2. this It is continuous more than 1 month；3. amount of sleep and (or) the dissatisfied of matter cause obvious worried or have impact on daily life.

Inclusive criteria：1. meet Western medicine diagnostic criteria, and the course of disease is more than more than 1 year, and with headache, giddy, palpitaition, strong Forget, the symptom such as dreaminess.2. the age was at 18~65 years old；3. agreeing to participate in experiment, informed consent form is signed.

Exclusion standard：1. the age is below 18 one full year of life or 70 one full year of life above persons；2. the gestational period, women breast-feeding their children；3. merge There is the severe primary disease patient such as angiocarpy, lung, liver, kidney and hemopoietic system；4. mental patient；5. it is all not by regulation medication or The not congruent judgement person that affects the treatment of data

2nd, test method

Control group：SHULE ANDING PIAN treatment is given, each 2mg, 30min is oral before sleeping every night, even served 28.During treatment Two groups are withdrawn other Western medicine hypnotics and hormone medicine and health products.

Treatment group：Give the capsule prepared by the embodiment of the present invention 2；Orally, one time 5,3 times on the one.1 month For 1 course for the treatment of, curative effect is evaluated after even served 2 courses for the treatment of.

3rd, observation of curative effect

Curative effect determinate standard according to《New Chinese medicine guideline of clinical investigations》Evaluation.

Clinical cure：The length of one's sleep recovers, or Nighttime sleep, in more than 6h, sleep is deep, hale and hearty after waking up；

It is effective：Sleep is clearly better, length of one's sleep increase more than 3h, Depth of sleep increase；

Effectively：Symptom mitigation, sleep increase less than 3h earlier above；

It is invalid：Insomnia is not improved or instead adds severe one after treatment.

4th, treatment results

Therapeutic evaluation is carried out according to curative effect judging standard, the results are shown in Table 1.

The clinical treatment outcome table of the present invention of table 1

Group	Number of cases	Recovery from illness	It is effective	Effectively	It is invalid	It is efficient（%）
							Treatment group	52	24(46.2)	15(28.8)	12(23.1)	1(1.9)	98.1
Control group	52	7(13.5)	15(28.8)	13(25.0)	17(32.7)	67.3

Treatment group totally 52, wherein recovery from illness 24, accounts for 46.2%；Effective 15, account for 28.8%；Effective 12, account for 23.1%； Invalid 1,1.9% is accounted for, total effective rate 98.1%；And the total effective rate of control group is 67.3%, two groups are compared, and are had very aobvious The meaning (P ＜ 0.05) of work.

Embodiment 6：Model case

1st, Zhao, female, 33 years old, intractable aypnia 5 years, difficulty falling asleep, sleep simple and easy awake, the daily length of one's sleep is less than 4 hours , it is vexed, lassitude hypodynamia, have a dizzy spell, two just adjust, and pale tongue, tongue is white, and arteries and veins is thin.Slept afterwards i.e. after taking capsule January of the present invention Normally, or so 7 hours can be slept every night, and subjective symptoms disappears substantially.Follow-up is not recurred after half a year.

2nd, Zhang, female, 43 years old, obstinate asomnia 3 years, downern half a year is taken.Patient is before 3 years because of operating pressure It is larger difficulty falling asleep occur, sleep simple and easy awake, fall asleep every night or so 4 hours, once interruption was taken SHULE ANDING PIAN and treated, 2 months Exacerbation of symptoms after preceding anxious state of mind, 1-2 hour of sleep is only capable of every night, vexed irritability is dizzy, binocular dryness, fullness and discomfort in chest and hypochondrium, Indigestion and loss of appetite, bitter taste, dry throat, stool is viscous not well, and urine is normal, and tongue is red, yellow and greasy fur, veins string.Take 1 month day of capsule of the present invention After sleep it is i.e. normal.Continue to take one month, eliminate the dependence to downern, after half a year follow-up do not recur.

Claims (7)

1. a kind of Chinese medicine composition for treating obstinate asomnia, it is characterised in that be made up of each bulk drug of following parts by weight： Cultivated land 15-25 parts, donkey-hide gelatin 7-12 parts, coptis 6-10 parts, radix scutellariae 5-8 parts, Chinese cassia tree 3-5 parts, Semen Ziziphi Spinosae (parched) 10-20 parts, cortex albiziae 8-15 parts, radix bupleuri 8-10 parts, Fructus Aurantii 6-10 parts, Tabasheer 6-10 parts, stiff silkworm 8-10 parts, vinegar turtle shell 10-20 parts, vinegar stir-baked PLASTRUM TESTUDINIS before treated with Vinegar 10-20 parts, calcined oyster shell 10-20 parts, cudrania root 6-15 parts.

2. according to the Chinese medicine composition described in claim 1, it is characterised in that the parts by weight of each bulk drug are：20 parts of cultivated land, Ah 10 parts of glue, 8 parts of the coptis, 8 parts of radix scutellariae, 4 parts of Chinese cassia tree, 15 parts of Semen Ziziphi Spinosae (parched), 12 parts of cortex albiziae, 8 parts of radix bupleuri, 8 parts of Fructus Aurantii, Tabasheer 8 parts, 9 parts of stiff silkworm, 15 parts of vinegar turtle shell, 15 parts of vinegar stir-baked PLASTRUM TESTUDINIS before treated with Vinegar, 15 parts of calcined oyster shell, 10 parts of cudrania root.

3. according to the Chinese medicine composition described in claim 1 or 2, it is characterised in that：It is prepared into according to Chinese medicine preparation and clinically fits Suitable preparation.

4. according to the Chinese medicine composition described in claim 3, it is characterised in that：Described preparation includes capsule, pill, dissipated Agent, granule, tablet, oral liquid or pill.

A kind of 5. method for preparing the Chinese medicine composition described in claim 1 or 2, it is characterised in that：Weighed by the parts by weight Each bulk drug；Each bulk drug is crushed, sieved, the auxiliary material or excipients needed for preparations shaping is added, is prepared into capsule, tablet Or pill.

A kind of 6. method for preparing the Chinese medicine composition described in claim 1 or 2, it is characterised in that comprise the following steps：

(1) each bulk drug is weighed by the parts by weight；

(2) cultivated land, radix bupleuri, Fructus Aurantii, cortex albiziae, stiff silkworm, vinegar turtle shell, vinegar stir-baked PLASTRUM TESTUDINIS before treated with Vinegar, calcined oyster shell, cudrania root are extracted two with water It is secondary, merge aqueous, be concentrated under reduced pressure, concentrate is spray-dried, it is standby；

(3) coptis, radix scutellariae, Chinese cassia tree and Semen Ziziphi Spinosae (parched) are extracted twice with 40-80% ethanol, ethanol extract is reclaimed into ethanol Afterwards, it is spray-dried, it is standby；

(4) it is well mixed after crushing donkey-hide gelatin, Tabasheer with the product obtained by step (2) and (3), adds pharmaceutical preparation auxiliary material Intermediate formulations are made in mixing, then finished dosage form is made through preparations shaping technique.

7. the Chinese medicine composition described in claim 1 or 2 is preparing the application in treating intractable aypnia disease drug.