CN103316245B - Chinese medicine preparation for treating infantile enuresis and preparation method thereof - Google Patents

Abstract

The invention discloses a Chinese medicine preparation for treating infantile enuresis. The Chinese medicine preparation comprises the following raw material medicines: mantis egg-case, schisandra chinensis, Huai rhizoma dioscoreae, semen cuscutae, codonopsis pilosula, fructus psoraleae, cornus officinalis, rhizoma polygonati, radix astragali, unprocessed fructus gardeniae, radix linderae, rhizoma atractylodis macrocephalae, dried tangerine, rhizoma cimicifugae, herba cistanche, radix geutianae, radix bupleuri, bamboo leaf, fructus rosae laevigatae, hedgehog hide, human placenta, limonite and roughhaired holly root. The Chinese medicine preparation disclosed by the invention has the functions of warming kidney yang, tonifying spleen qi, replenishing lung qi, enlivening heart spirit and consolidating urinary bladder, and is mainly used for treating enuresis caused by deficiency of lung and spleen qi and deficiency of kidney qi; the preparation technology is simple and convenient, little toxic and side effects are caused, and the administration is convenient; the medicine is easy to prepare; the new medicine with low cost can directly reach the focus; and the curing time is short, and the enuresis does not easily recur after cured.

Description

A kind of Chinese medicine preparation for the treatment of bed-wetting and preparation method thereof

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or raw mineral materials, particularly a kind of Chinese medicine preparation for the treatment of bed-wetting and preparation method thereof.

Background technology

The enuresis refers to that 3 years old above children's can not Autonomous Control urinate, the middle incontinence of urine of often sleeping, a kind of disease that feel at the rear of waking up.Infant period, due to body, to grow inentirely, internal organs are tender and lovely, " the kidney being always deficient ", and intelligence is incomplete, and the self-control of urinating not yet forms; School age population also often plays excessively because of game on daytime, and night, ripe " deep sound sleep ", bed wetter accidentally occurred, all non-morbid state.Age surpasses 3 years old, 5 years old above child particularly, the frequent enuresis in sleeping, the lighter's a few days once, severe one can a night for several times, be morbid state, side's title enuresis.Boy is higher than girl in primary disease morbidity, and part has obvious family history.The course of disease is longer, or outbreak repeatedly, and severe cases sleep on daytime also the enuresis can occur, and severe patient produces inferiority complex, affects physical and mental health and growth promoter.

The document of the enuresis is recorded, see the earliest in < < through > >, as < < Ling Shu Miraculous Pivot or Divine Axis nine kinds of needles > >: " bladder is not about incontinence of urine." to explicitly point out the enuresis be due to due to bladder can not retrain.< < General Treatise on the Cause and Symptoms of Diseases miscellaneous child diseases duke or princess under an emperor > > is cloud also: " bed wetter, this is by deficiency-cold in the urinary bladder, therefore can not be on water also." after ancient Chinese medicine doctor be described more.Modern medicine is diagnosed by x-ray, finds that the infant of some intractable enuresis is relevant with spina bifida occulta, this class infant treatment difficulty.Etiology and pathogenesis: < < Plain Questions passages through which vital energy circulates another matter > > cloud: " drink people in stomach, transporting essential substances in solution, upper defeated in spleen, spleen-QI transporting the essence to the whole body, is above attributed to lung, regulating fluid apssage, lower defeated bladder ".Diet people stomach has been described, after digestion, the precise and tiny spleen that spreads to wherein, by defeated in lung on spleen, the Xuan Fasu by lung falls, and makes water channel unobstructed, and unnecessary moisture in body, transporting to down bladder becomes urine, then excretes, and this is the process of water liquid metabolism.The secret allusion quotation opinion of < < Plain Questions LINGLAN > > cloud: " here body fluid is hidden for bladder person, the viscus likened to a pond, and gasification can go out." cloud again: " here water channel goes out for three warmers person, the organ in charge of water circulation." and the main water of kidney, with bladder the exterior and the interior each other, it is warm that the gasification of bladder depends on kidney qi abundance.As can be seen here, the generation of urine and excretion, with lung, spleen, kidney, three warmers, bladder close relation.Though the pathogenesis of the enuresis is mainly lost in constraint at bladder, so and lung, spleen, renal dysfunction, and there is relation in qiactivity of triple energizer mistake department.Its Etiological is instability of kidney QI, deficiency of both the splenic and pulmonary QI, dampness-heat of the liver.Instability of kidney QI is the Etiological of the enuresis, how by natural endowment deficiency, to be caused, as premature labor, twins, congenital feebleness etc., vigour is lost and filled, and insufficiency of kidney-YANG, below element deficiency and cold, can not replenishing vital QI with drugs of warm nature bladder, and functioning of bladder functional disorder, closes and hides dereliction of duty, can not restrict urine, and be the enuresis.Deficiency of both the splenic and pulmonary QI element body is weak, suffer from repeatly cough with asthma and rush down profit, or after serious disease, spleen lung is all empty.Insufficiency of the spleen transformation failure of spleen, can not transfer precise and tinyly, and it is not all right that the deficiency of the lung is controlled joint, regulating fluid apssage dereliction of duty, and qiactivity of triple energizer mistake department, the urinary bladder being out of control, body fluid is not hidden, and forms the enuresis.If insufficiency of the spleen mistake is supported, deficiency of heart-QI, or expectorant accumulates in turbid, the tired mind of covering, also can make children's's night tired sleeping not wake up and the enuresis.Dampness-heat of the liver is irascible temperament usually, being unable to satisfy the wants, and stagnated heat of liver channel, or the body of fat phlegm-damp, dampness-heat of the liver pents up, and catharsis is not normal, and the meridians ring external genitals of liver, and the liver failing to maintain the normal flow of QI affects the normal tonneau of three warmers water channel, damp and hot urgent note bladder and cause the enuresis.In addition, also there is children's to lack since the childhood education, do not form the custom of initiatively getting up and urinating night, let alone from losing, in the course of time, the forming the habit property enuresis.Clinical diagnosis: 1. age of onset is more than 3 one full year of life.2. the DR that sleeps is darker, is difficult for waking up, wets the bed every night or every other day, very every nocturnal enuresis several person.3. routine urinalysis and urine are cultivated without anomaly.4.X ray examination, part infant can be found spina bifida occulta, or makes urinary tract radiography deformity as seen.Therapeutic Principle: primary disease treatment, deficiency syndrome are astringent or styptic treatment for spontaneous sweating with the kidney warming, and strengthening the spleen and tonifying the lung is main; Excess syndrome be take eliminating pathogen in the liver clearing away heat-damp and promoting diuresis as main, coordinates the method treatments such as acupuncture, laser, external treatment.

Modern medicine thinks, children's is after 2～3 years old, and cerebral cortex can have been controlled spinal micturition center and control and urinate, and in sleep because urine meaning is awakened.As because of irrational bladder training, the obstacle of psychological or spiritual aspect, the change of environment, psychentonia, the factors such as health is overworked make cerebral cortex and subcortical center functional disorder, and the control of impact to micturition centre can not be accepted the urine meaning from bladder when sleeping soundly, and when awakening raw reflex voiding, be the enuresis.Its mechanism mainly contain following some: pivot nervous system functional development delay of maturation; Vassopressin (ADH) diacrisis; When bladder function disorderly (nervous bladder) is urinated, sphincter and detrusor are inharmonious, occur in the daytime frequent micturition, and night, bladder instability was shunk, and bladder capacity is few and cause the enuresis.

In treatment, take three large strategies: the appearance of increase bladder capacity, reduce urine amount at night, promotion night urination being controlled function, to reaching maturity, takes wherein any strategy can make enuresis nocturna improve and even cure more.Treatment can be divided into behavior therapy and Drug therapy again.

Behavior therapy mainly adopts bladder function training and wakes therapy up.Guiding children drinks more water by day as far as possible, makes bladder capacity expansion, when infant will be urinated, advises it to suppress urine as far as possible, until be impatient at, increases bladder capacity.In addition, when infant is urinated by day, the process of urinating is carried out as far as possible several times, strengthens the interior flesh of the musculus sphincter of external urethra and abdomen to the control of urinating, sagging to control bladder neck, reaches the object of controlling the enuresis night.Wake treatment up and use urine-wet alarm device or alarm clock, humidity sensor is placed on infant underwear, one urinates reports to the police and wakes infant up, to train infant to the sensitivity of expansion of the bladder and to revive in time.

Drug therapy relates generally to three class medicines: one is synthetic vassopressin, and vasopressin is that antidiuretic hormone secretion deficiency is the theoretical foundation of clinical practice synthetic vassopressin.Research finds that vasopressin is apart from outside antidiuretic activity, is also improved the effect of sleep disorder, promotion awakening.Vassopressin can concentrated urine, thereby reduces amount of urine and intravascular pressure, and neck of bladder is declined, and detrusor contractions reduces, and enuresis improves.Take Desmopressin as representative.This type of medicine in a short time curative effect is obvious, but after drug withdrawal, relapse rate is higher, during medication, must restrict water supply in case side effect such as water intoxication, hypertension.Two is anticholinergic agents.Oxibutynin is most widely used cholinergic receptor-blocking agent in current enuresis treatment, its therapy apparatus is built in removing smooth muscle of bladder spasm, and lax detrusor, reduces its contraction frequency, thereby playing therapeutical effect, is the choice drug that is associated with the enuresis of unstable bladder.Three is meclofenoxate, is central stimulant, can be excited, be conducive to wake up.In recent years research is thought, the effect that it has the metabolism of promotion brain, improvement to remember.Though Western medicine can reach the effect of controlling symptom, because toxic and side effects is large, make patient be difficult to accept.

Summary of the invention

Technical problem to be solved by this invention is, provides that a kind of formula is simple, processing technology is easy, the little and convenient drug administration of toxic and side effects, and medicament is easy to manufacture, new drug with low cost.The present invention is Chinese medicine preparation, but the gentle Chinese medicine of selected abnormal smells from the patient makes the abnormal smells from the patient of Chinese medicine preparation also light, is applicable to child's mouthfeel, allows child be unlikely to produce boredom.The present invention adopts the Chinese crude drug of different properties, has carried out science compatibility, can reach desirable therapeutic effect, and safety, and toxic and side effects is little, and preparation is simple, the focus of going directly, and healing time is short, after curing, is difficult for recurrence.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of bed-wetting, in described Chinese medicine preparation, the ratio of weight and number of various crude drug is: 10～20 parts of Ootheca Mantidiss, 10～20 parts of Fructus Schisandrae Chinensis, 10～25 parts of RHIIZOMA DIOSCOREAE fr0m Henan of China, 10～25 parts of Semen Cuscutae, 10～20 parts of Radix Codonopsis, 10～25 parts of Fructus Psoraleaes, 10～30 parts of Fructus Corni, 10～20 parts of Rhizoma Polygonatis, 10～25 parts of the Radixs Astragali, 10～20 parts of Fructus Gardeniae, 10～20 parts of the Radixs Linderae, 10～25 parts of the Rhizoma Atractylodis Macrocephalaes, 10～25 parts of Pericarpium Citri Reticulataes, 10～30 parts of Rhizoma Cimicifugaes, 10～30 parts of Herba Cistanches, 10～30 parts of Radix Gentianaes, 10～30 parts of Radix Bupleuri, 10～20 parts, Folium Bambusae, 10～20 parts of Fructus Rosae Laevigatae, 10～20 parts of Corium Erinacei Seu Hemiechianuss, 10～20 parts of Placenta Hominiss, 10～20 parts of 10～20 parts of Limonitum and Radix Ilicis Asprellaes.

The Chinese medicine preparation of described treatment bed-wetting, the ratio of weight and number of each crude drug can also be: 10～20 parts of Ootheca Mantidiss, 10～15 parts of Fructus Schisandrae Chinensis, 10～25 parts of RHIIZOMA DIOSCOREAE fr0m Henan of China, 15～25 parts of Semen Cuscutae, 10～20 parts of Radix Codonopsis, 10～20 parts of Fructus Psoraleaes, 10～20 parts of Fructus Corni, 10～15 parts of Rhizoma Polygonatis, 10～20 parts of the Radixs Astragali, 10～15 parts of Fructus Gardeniae, 10～20 parts of the Radixs Linderae, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Pericarpium Citri Reticulataes, 15～20 parts of Rhizoma Cimicifugaes, 10～20 parts of Herba Cistanches, 10～20 parts of Radix Gentianaes, 15～30 parts of Radix Bupleuri, 10～20 parts, Folium Bambusae, 15～20 parts of Fructus Rosae Laevigatae, 10～20 parts of Corium Erinacei Seu Hemiechianuss, 15～20 parts of Placenta Hominiss, 10～20 parts of 10～15 parts of Limonitum and Radix Ilicis Asprellaes.

The Chinese medicine preparation of described treatment bed-wetting, the ratio of weight and number of each crude drug can be again: 10～15 parts of Ootheca Mantidiss, 14～20 parts of Fructus Schisandrae Chinensis, 10～20 parts of RHIIZOMA DIOSCOREAE fr0m Henan of China, 15～20 parts of Semen Cuscutae, 15～20 parts of Radix Codonopsis, 15～20 parts of Fructus Psoraleaes, 10～20 parts of Fructus Corni, 15～20 parts of Rhizoma Polygonatis, 15～25 parts of the Radixs Astragali, 15～20 parts of Fructus Gardeniae, 10～15 parts of the Radixs Linderae, 15～25 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Pericarpium Citri Reticulataes, 10～30 parts of Rhizoma Cimicifugaes, 15～30 parts of Herba Cistanches, 15～30 parts of Radix Gentianaes, 10～20 parts of Radix Bupleuri, 10～20 parts, Folium Bambusae, 10～16 parts of Fructus Rosae Laevigatae, 10～20 parts of Corium Erinacei Seu Hemiechianuss, 10～15 parts of Placenta Hominiss, 15～20 parts of 13～20 parts of Limonitum and Radix Ilicis Asprellaes.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of bed-wetting, and the dosage form of described Chinese medicine composition is capsule, and described preparation method comprises the following steps:

A, get Ootheca Mantidis, Fructus Psoraleae, Herba Cistanches and Rhizoma Polygonati, the water soaking 1-2 hour that adds 5-10 doubly to measure, extracts the volatile oil of 2-5 hour, collects volatile oil, and medicinal liquid filters, standby;

B, get Fructus Schisandrae Chinensis, RHIIZOMA DIOSCOREAE fr0m Henan of China, Semen Cuscutae, Radix Codonopsis, Fructus Corni, the Radix Astragali, Fructus Gardeniae, the Radix Linderae, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Cimicifugae, Radix Gentianae, Radix Bupleuri, Folium Bambusae, Fructus Rosae Laevigatae, Corium Erinacei Seu Hemiechianus, Placenta Hominis, Limonitum and Radix Ilicis Asprellae, mix with the medicinal residues of described step a, add 60%-90% ethanol, soak 0.5-1.5 hour, extract twice, each 1-2 hour, adding for the first time 5-10 doubly measures, add for the second time 5-10 and doubly measure, merge extractive liquid,, filters; 1.10-1.50 when concentrating filtrate to relative density and being 80 ℃, precipitate with ethanol twice, adjusts concentration of alcohol to 60%-90%, gets supernatant concentration to relative density 1.10-1.50 while being 80 ℃, obtains extractum;

C, get above-mentioned extractum, the volatile oil and the vegetable oil that add step a to obtain, the addition of vegetable oil accounts for the 2-5% of extractum and volatile oil gross mass, mix, with colloid mill, grind 10 minutes, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.

In described step a, the extraction of Ootheca Mantidis, Fructus Psoraleae, Herba Cistanches and the contained hair care oil of Rhizoma Polygonati, is steam distillation or supercritical fluid extraction.

In described step b, described refinement adopts membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation or macroporous resin method.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of bed-wetting, and the preparation process of described enema is: all described crude drug are soaked 30 minutes to 1 hour to heated and boiled 30～40 minutes, filter filtrate for later use; Filtering residue adds water and heats for the second time, boils 30～40 minutes, filters filtrate for later use; Filtering residue adds water again, and heated and boiled is 30～40 minutes for the third time, filters; Three filtrates are combined, and heating is concentrated into pasty state medicinal liquid.

For solving the problems of the technologies described above, the present invention also provides a kind of use way of enema of Chinese medicine preparation for the treatment of bed-wetting, during use, get above-mentioned enema 100 mL～200 mL at every turn, retention enema pours into 30mL～50 mL at every turn, with No. 12 oxygen catheters and 50 mL syringes, injects, insertion depth is 15 cm～20 cm, 2～3 times/d, each 20 min-40 min, 7d is 1 basic course for the treatment of.

For solving the problems of the technologies described above, the present invention provides a kind of dosage form for the treatment of the Chinese medicine preparation of bed-wetting again, and pharmaceutical dosage form can be: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, powder, enema and patch.

Described Chinese medicine composition, medicine is decocted in use decoction and is taken, and 1 dose of every day, decocting takes at twice, and every 7 days is a course for the treatment of; When this Chinese medicine composition is pill, capsule or tablet while using, three times on the one, every 7 days is a course for the treatment of; After drug decocting, make enema, or make patch and stick abdominal part or umbilicus place, 7 d are 1 basic course for the treatment of.

Umbilicus, cave name Shenque, for the important acupuncture point of conception vessel, Gu has saying of " Shenque, curing mainly all kinds of diseases and ailments, and old man, empty people have loose bowels as god ", position, umbilicus place is again that chong channel is through row part, Conception Vessel and Governor Vessel is the exterior and the interior each other, and commander's human body is all through hundred arteries and veins, therefore umbilical part is maintained close ties with by above meridians and all internal organs organs of whole body.Human body stomach wall is thin, and local application is easy to absorb, and no pain, and external application of Chinese medicine Shenque can reach dispelling cold and activating YANG, regulating QI to relieve pain, rapidly the merit of dysentery relieving disease.

Chinese medicine preparation of the present invention has warming and recuperating the kidney-YANG, mends strengthening spleen and lung, the nourishing kidney that clears away heart-fire, eliminating pathogen in the liver are only lost, the effect of astringent or styptic treatment for spontaneous sweating bladder, cure mainly Children with Renal QI-insufficiency, gasification function imbalance, close hide that mistake department can not retrain water channel and feel repeatly that exogenous cold, asthma take place frequently, improper feeding is become thin thin and weak and wish row and can not, the symptoms such as incontinence of urine; And processing technology is easy, the little and convenient drug administration of toxic and side effects, medicament is easy to manufacture, new drug with low cost.The present invention is Chinese medicine preparation, but the gentle Chinese medicine of selected abnormal smells from the patient makes the abnormal smells from the patient of Chinese medicine preparation also light, is applicable to child's mouthfeel, allows child be unlikely to produce boredom.Take coloclysis, paste the therapies such as umbilicus and can greatly alleviate sick child's discomfort.The present invention adopts the Chinese crude drug of different properties, has carried out science compatibility, can reach desirable therapeutic effect, and safety, and toxic and side effects is little, and preparation is simple, the focus of going directly, and healing time is short, after curing, is difficult for recurrence.

The specific embodiment

According to children's's physiology, pathological characteristic, its enuresis reason is the features such as the friendship, stagnated heat of liver channel of deficiency of kidney-QI, asthenia of pulmonosplenic qi, heart kidney, in addition, still has the bad habit person of forming.If lack since the childhood education, do not form good night urination custom, or still use baby's paper diaper in 3 years old later, and let alone from losing.Said in < < Jing Yue's complete work > >: " it has children's not add restraint and vertical wantonly normal something lost persons from children, and this is used to and without exhausting, also, when blaming its god, non-medicine in one's power for the disease of will meaning.”

Instability of kidney QI is the Etiological of the enuresis, how by natural endowment deficiency, to be caused, as premature labor, twins, congenital feebleness etc., vigour is lost and filled, and insufficiency of kidney-YANG, below element deficiency and cold, can not replenishing vital QI with drugs of warm nature bladder, and functioning of bladder functional disorder, closes and hides dereliction of duty, can not restrict urine, and be the enuresis.Deficiency of both the splenic and pulmonary QI element body is weak, suffer from repeatly cough with asthma and rush down profit, or after serious disease, spleen lung is all empty.Insufficiency of the spleen transformation failure of spleen, can not transfer precise and tinyly, and it is not all right that the deficiency of the lung is controlled joint, regulating fluid apssage dereliction of duty, and qiactivity of triple energizer mistake department, the urinary bladder being out of control, body fluid is not hidden, and forms the enuresis.If insufficiency of the spleen mistake is supported, deficiency of heart-QI, or expectorant accumulates in turbid, the tired mind of covering, also can make children's's night tired sleeping not wake up and the enuresis.Dampness-heat of the liver is irascible temperament usually, being unable to satisfy the wants, and stagnated heat of liver channel, or the body of fat phlegm-damp, dampness-heat of the liver pents up, and catharsis is not normal, and the meridians ring external genitals of liver, and the liver failing to maintain the normal flow of QI affects the normal tonneau of three warmers water channel, damp and hot urgent note bladder and cause the enuresis.

External application of Chinese medicine is one of the most frequently used clinically external treatment of Chinese medicine, the < < Handbook of Prescriptions for Emergencies > > of Jin Daige flood work, the < < Qianjin Yao Fang > > of the Tang Dynasty Sun Simiao, < < Qianjin Yi Fang > >, in the < < Compendium of Materia Medica > > of the < < medical secrets of official > > of Wang Taozhu and Ming Dynasty's Li Shizhen (1518-1593 A.D.), contained therapy has all related to external application of Chinese medicine.Because meridians have interior genus internal organs, outer network podomere, link up the exterior and the interior, run through upper and lower effect, thus not only can treat local patholoic change, but also can reach by external application the object for the treatment of systemic disease.Medicine, by the stimulation to the local acupuncture point of umbilical part (SHENQUE acupoint), penetrates through skin, excites through feeling pulse gas, promotes internal organs QI-blood circulation, plays therapeutical effect; Umbilicus is thinner, neural, blood vessel is abundanter, therefore umbilical part has compared with absorbability by force and rapidly, there are good impression and conduction function, when the medicine with suitable treats in umbilical part, all local teleneuron be can stimulate, internal organs and tissue physiology's activity and pathological change improved, the immunity of enhancing body and resistance against diseases.The treatment of external application of Chinese medicine thermal-arrest, medication, moxibustion are in one, play the effect of invigorating the spleen to arrest diarrhea, avoided oral simultaneously and injected bring inconvenient and painful, the head of a family and infant are easy to accept, and lasting medicine, avoid the first pass effect of liver and interference and the Degradation of gastrointestinal factor, reduced individual variation, rapid-action, strong drug action, without wound, no pain, easy to use.

In side, Ootheca Mantidis, Fructus Schisandrae Chinensis, Fructus Corni, Fructus Psoraleae, Fructus Rosae Laevigatae, Corium Erinacei Seu Hemiechianus, Placenta Hominis nourishing kidney-YIN are with urine reducing, Semen Cuscutae, Herba Cistanches, Placenta Hominis warming and recuperating the kidney-YANG are to warm up bladder, for deficiency of kidney-QI, decline of the fire from the gate of life, lower first deficiency and coldness, can not retrain water channel and cause clear urine in large amounts, again and again wet the bed.RHIIZOMA DIOSCOREAE fr0m Henan of China, Limonitum, Radix Linderae warming the spleen are astringent or styptic treatment for spontaneous sweating, for the card of the thin deficiency-weakness of spleen-QI of spiritlessness and weakness, inappetence, large loose stool.Radix Codonopsis, the Radix Astragali, Rhizoma Atractylodis Macrocephalae QI invigorating, for insufficiency of lung-QI, bladder is not taken the photograph, deficiency of the upper portion of the body resulting in inability to control the lower portion, so that enuresis nocturna, in the daytime pollakiuria.Fructus Gardeniae, Folium Bambusae, Radix Ilicis Asprellae clearing away heart-fire, for agitation, disturbing, daytime is how moving few quiet, is difficult to self-control, or dysphoria with feverish sensation in the chest palms and soles, the card of emaciated physique.Pericarpium Citri Reticulatae is regulated the flow of vital energy, Rhizoma Cimicifugae ascending spleen-QI, and Radix Gentianae, Radix Bupleuri eliminating pathogen in the liver heat clearing away, for damp and hot strongly fragrant in Liver Channel, tenesmus bladder and cause irascible temperament, the red red card of order eyeball.All medicine compatibilities can reach the effect of rapid the kidney warming sun, strengthening the spleen gas, the awake mind of tonifying the lung gas, solid bladder.

Ootheca Mantidis, the kidney invigorating, controlling nocturnal emission with astringent drugs.Control seminal emission, nebulousurine, frequent micturition, the enuresis, leucorrhea with red and white discharge, sexual impotence, premature ejaculation.1. < < herbal classic > >: " main damaging the spleen and stomach, hernia abdominal mass, impotence, the raw son of benefit essence.Woman's blood closes lumbago, logical five types of stranguria, diuresis water channel.It is deficient that " 2. < < does not record > >: " treats man, and five hide feeble QI, dream consumption of essence, incontinence of urine.Essence is leaked in " 3. < < property of medicine opinion > >: " main man's renal failure, and essence, from going out, is suffered from cold caused by deficiency person and can be stopped it.Normal urination only, cannon order heat, hollow food it.Void and normal urination add and use it." 4. < < Amplification on Materia Medica > >: " controls urine nebulousurine.It is dripping that " 5. the beautiful Chinese catalpa medicine of < < solution > >: " controls foul leukorrhea, otalgia, sore throat, abdominal mass hernia, a fishbone or other bone caught in the throat." usage and consumption, for oral administration: to decoct soup, 1.5～3 money; Or enter ball, loose.Hyperactivity of fire caused by deficiency of YIN or bladder have the careful clothes of hot person.1. < < Collective Notes to Canon of Materia Medica > >: " Os Draconis are controlled and are let out essence.Fear Flos Inulae.Mulberry is worn in " 2. < < property of medicine opinion > >: " fear." 3. < < Bencao Jingshu > >: " all consumption of essence incontinence of urine, fire of moxibustion too Sheng person should be used it less.The how fiery people's misuse of " 4. < < herbal classic is met former > >: " deficiency of YIN, the anti-void sun that helps, causes the red pain in the penis of urinating more, and persistent erection of the penis consumption of essence, can not know." clinical practice: treatment enuresis, get Ootheca Mantidis, Fructus Alpiniae Oxyphyllae each 1.5 liang (child was with 1 liang in 5～12 years old), decocting, day takes 1 dose.11 examples are controlled in examination, and generally serveing on 3～4 doses can take effect, then takes 2～3 doses, can consolidate curative effect.

Fructus Schisandrae Chinensis is as medical material, record the earliest in the > > of < < Sheng Nong's herbal classic, be listed in top grade.Ancients once evaluated like this Fructus Schisandrae Chinensis " the sweet acid of Fructus Schisandrae Chinensis skin and flesh, core first are arduous, have saline taste this five tastes are all also." be perhaps the origin of its name, Fructus Schisandrae Chinensis is warm in nature.Modern pharmacological research shows, Radix Schisandrae Bicoloris contains multiple nutritional components, as schizandrin, malic acid, citric acid, tartaric acid, succinic acid, fatty oil, volatile oil, saccharide, resin, vitamin C etc., also contain the trace element such as tungsten, ferrum, manganese, zinc, phosphorus.Fructus Schisandrae Chinensis also has the effect of the pathogenic microorganism such as certain anti-bacteria breeding, Fructus Schisandrae Chinensis water decoction to tubercule bacillus, bacillus subtilis, escherichia coli, Bacillus typhi, staphylococcus aureus, streptococcus, Diplococcus pneumoniae, have stronger inhibitory action.Utilize clinically the effect of its astringent therapy, be used for astringing the lung, hidroschesis, arresting seminal emission antidiarrheal etc.

Rhizoma Dioscoreae sweet in the mouth, property are put down, and enter lung, spleen, kidney channel; Not dry oiliness, there are strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, grow that will is calmed the nerves, the effect of life lengthening; Cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, the red disease such as swollen, fat of the frequent micturition of quenching one's thirst, seminal emission premature ejaculation, leukorrhagia nebulousurine, skin.< < Compendium of Materia Medica > > summarizes five large functions " kidney tonifying gas, strengthening the spleen and stomach, stopping leak dysentery, the saliva that reduces phlegm, profit skin ".Rhizoma Dioscoreae is cooked congee or simmers after ripe and take with crystal sugar, and, colitis poor to health, deficiency of the kidney chronic diseases are all effective in cure.Strengthen the spleen and stomach: treatment weakness of the spleen and stomach, have loose bowels, body is tired, lack of appetite, sweating due to debility.Lung benefiting nourishing kidney: this product is cold not dry, sweet in the mouth matter profit, can treat lung suffer from a deficiency of the kidney damage quench one's thirst, pass out semen, be with inferior disease.Be described as angle's medicine.

Semen Cuscutae invigorating the liver and kidney, beneficial marrow, improving eyesight.Control soreness of waist and knee joint, seminal emission, quenches one's thirst, dripping urination, and order is dark.(1) invigorating the liver and kidney: this product is the kidney invigorating reducing urination, the only common medicine of seminal emission.Soreness of waist and knee joint, sexual impotence, seminal emission for deficiency of the liver and kindey.This moral character is soft and moist, flat invigorating the liver and kidney and not dry.(2) antiabortive: for weak, to be easy to Aborter, often to join Herba Taxilli, Radix Dipsaci.1. < < herbal classic > >: " main continuous wound absolutely, tonifying for the deficiency, physical strength profiting, fertile strong people, takes improving eyesight for a long time." 2. < < Leigong Paozhilun > >: " mends artificial satellite's gas, the muscle arteries and veins of helping others." 3. < < does not record > >: " supports flesh reinforcing YIN-essence, hard muscles and bones, and stem invasion by pathogenic cold, essence, from going out, is drowned and is had the heeltap, and bitter taste is dry thirsty, and cold blood is for long-pending." 4. < < property of medicine opinion > >: " controls man woman cold caused by deficiency, and sperm adding and marrow healthing, goes pain in the lumbar region knee joint cold, and main quenching one's thirst hankered again." 5. < < Japan hanako materia medica > >: " mends five kinds of strain and seven kinds of impairment, controls and lets out essence, hematuria, profit cardiopulmonary.The dirty wind of " 6. king accounts for well: " tonifying liver is empty." 7. < < Shandong Chinese medicine > >: " controls married woman Chang Xi miscarriage." for oral administration: to decoct soup, 3～5 money; Or enter ball, loose.External: stir-fry is ground and dressed.Compatibility and incompatibility of drugs: 1. < < Collective Notes to Canon of Materia Medica > >: " wine is good.Rhizoma Dioscoreae, Colophonium make ， E Di bacterium for it." 2. < < Bencao Jingshu > >: " kidney man is fire how, and strong sun not flaccidity person is avoided it, and constipation due to dry stool person also avoids it." 3. < < must join herbal > >: " anemia of pregnant woman, metrorrhagia, postcoital protrusion, constipation, kidney have fire, deficiency of YIN fire to move, six forbiddings."

Radix Codonopsis invigorating middle warmer, QI invigorating, promotes the production of body fluid.Control weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.1. < < herbal classic is met former > >: " lung heat clearing." 2. < < Bencao Congxin > >: " invigorating the spleen and replenishing QI, and taste, relieving thirst and restlessness." 3. < < detailed outline pick up any lost article from the road > >: " controls the deficiency of the lung, lung benefiting gas." 4. the medicinal herbs > > among the people of < < science: " hematinic.Be applicable to chronic anaemia, chlorosis, leukemia, adenopathy, rickets." 5. < < Chinese crude drug handbook > >: " controls asthenia internal injury, intestinal cold in the stomach, and the sliding chronic dysentery of rushing down, asthma excessive thirst, heating spontaneous perspiration, metrorrhagia, tire produce all diseases.1. the herbal > > of < < China: for oral administration: to decoct soup, 6-15g; Or endure cream, enter ball, loose.Promote the production of body fluid, nourish blood and should give birth to use; Invigorating the spleen to benefit the lung should be processed use.2. < < Chinese Pharmacopoeia > >: decoction, 9～30g.Compatibility and incompatibility of drugs 1. < < must join herbal > >: the stagnation of QI, fury Sheng person forbidding.2. < < medicine cage essay > >: fullness in the epigastrium and abdomen has fiery person to avoid it.3. the herbal > > of < < China: excess syndrome, heat syndrome are prohibited clothes, and vital QI being weakened and pathogen being violent card, should not apply separately.

Fructus Psoraleae reinforcing the kidney and supporting YANG.Control the cold diarrhea of suffering from a deficiency of the kidney, the enuresis, spermatorrhea, frequent micturition, sexual impotence, chills and pain of the waist and kness, deficiency and coldness is breathed heavily and is coughed.External curing vitiligo.1. < < property of medicine opinion > >: " main man's pain in the lumbar region, the cold capsule of knee joint is wet, stupid by all cold numbness, and only normal urination, cold in abdomen." 2. < < Japan hanako materia medica > >: " emerging male sexuality, treating consumptive disease of cold nature, improve visual and auditory acuity." 3. < < Kaibao Bencao > >: " main five kinds of strain and seven kinds of impairment, wind cold caused by deficiency, bone marrow wound loses, the cold essence stream of kidney and the induced abortion of married woman's vim and vigour." 4. < < product remittance essence is wanted > >: " controlling nocturnal emission with astringent drugs gas." 5. < < detailed outline > >: " controls diarrhea due to kidney-dificiency, the logical gate of vitality, and warm public region, holds back spirit." 6. the beautiful Chinese catalpa medicine of < < solution > >: " warm water and soil, digestion diet, rises and reaches taste, convergence lingering diarrhea, seminal emission, leukorrhagia, drown many, just slide all cards." 7. > > is wanted in < < medical center bun: " controlled deficiency and coldness and breathed heavily and cough." for oral administration: to decoct soup, 1.5～3 money; Or enter ball, loose.External: grind wiping or steeping in wine into powder and put on the skin.Compatibility and incompatibility of drugs: hyperactivity of fire caused by deficiency of YIN person avoids clothes.1. < < Haiyao Bencao, Oversea Materia Medica > >: " dislike Radix Glycyrrhizae." 2. < < detailed outline > >: " avoids all blood, obtains Semen Juglandis, linum is good." 3. < < Bencao Jingshu > >: " all sick deficiency of YIN fire are moving, nocturnal emission, hematuria, the puckery and day red bitter taste dry tongue of oliguria, constipation due to dry stool, interior hotwork is thirsty, fire rises conjunctival congestion, easily hungry noisy, damp and hot one-tenth flaccidity, so that the weary unable person of bone, neither should take." 4. < < must join herbal > >: " deficiency of YIN is sunk, interior-heat excessive thirst, the dizzy deficiency of vital energy, conceived heart born of the same parents heat, two constipation person forbiddings.

Fructus Corni invigorating the liver and kidney, arresting seminal emission gas, Gu collapse.Control soreness of waist and knee joint, dizzy, tinnitus, sexual impotence, seminal emission, frequent micturition, deficiency of the liver cold and heat, incessant sweating due to debility, the heart shakes scattered pulse.Liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating collapse, interior-heat, quench one's thirst.Warming the liver the kidney invigorating, except a wind cutting, only menorrhagia, controls senile frequent micturition.1. < < herbal classic > >: " pathogen cold and heat under the main heart, warming middle-JIAO, by cold-damp numbness, go three worms." 2. < < Leigong Paozhilun > >: " primordial qi strengthening gas, secret essence." 3. < < does not record > >: " the intestines and stomach ailment said due to cold or exposure, cold and heat hernia abdominal mass, wind syndrome of head, pathogenic wind goes, nasal obstruction, icteric sclera, deafness, pimples, warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, perspires, reinforcing YIN-essence, benefit essence, settling five organs, logical nine orifices, stop normal urination, improving eyesight, brute force." 4. < < property of medicine opinion > >: " controls brain osteodynia, and only month water is indefinite, the kidney invigorating gas; Xing Yangdao, adds marrow, treats tinnitus, except skin ulcer on face, and the diaphoresis of main energy, only old man's urine does not save." 5. < < Japan hanako materia medica > >: " warm waist knee joint, helps water dirty, except a wind cutting, cuts one by one gas, and broken Disorder knot, controls wine Zha." 6. < < pearl sac > >: " warming the liver." 7. < < book on Chinese herbal medicine is asked former > >: " be chronic diarrhea only, the fever and sweating of having a guilty conscience." for oral administration: to decoct soup, 1.5～3 money; Or enter ball, loose.All gate of vitality's heateds, strong sun is flaccidity not, have damp and hotly, and the puckery person of urine leaching avoids clothes.< < Collective Notes to Canon of Materia Medica > >: " Fructus polygoni hydropiperis makes for it.Dislike Radix Platycodonis, Radix Saposhnikoviae, Radix Stephaniae Tetrandrae."

Rhizoma Polygonati invigorating the spleen and replenishing QI, profit cardiopulmonary, bone and muscle strengthening.Control deficient cold and heat, pulmonary tuberculosis hemoptysis, the empty lack of appetite of body after being ill, muscles and bones is weak, rheumatalgia, wind favus disease.1. < < does not record > >: " main invigorating the spleen and replenishing QI, except rheumatism, settling five organs." 2. < < Japan hanako materia medica > >: " mends five kinds of strain and seven kinds of impairment, helps muscles and bones, only hungry, cold-resistant summer-heat, strengthening the spleen stomach, profit cardiopulmonary." 3. < < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " tonify deficiency adds essence." 4. < < detailed outline > >: " mends all void, cold and heat only, replenishing essence marrow, lower three corpse worms." 5. < < Bencao Congxin > >: " flat filling blood and moistening." 6. the modern Practical Chinese medicinal > of < < >: " is for intermittent fever, gout, periostitis, ascarid, hypertension." 7. < < Traditional Chinese Medicine in Sichuan will > >: " the kidney invigorating lung moistening, benefiting qi and nourishing yin.Control insufficiency of the spleen yellowish complexion, cough due to deficiency of the lung, muscles and bones acid numbness is unable, and puerperal, QI and blood was weak." 8. Chinese herbal medicine handbook > > is commonly used in < < Hunan Rural Areas: " kidney and spleen invigorating, bone and muscle strengthening, the lung moistening and production of body fluid promoting." for oral administration: to decoct soup, 3～5 money (1～2 liang of fresh person); Endure cream or enter ball, loose.External: decoct washing.Invasion by pathogenic cold is had loose bowels, and phlegm-damp feeling of fullness stagnation of QI person avoids clothes.1. < < detailed outline > >: " avoid Fructus Mume, flower, leaf, son and with." 2. < < herbal classic is met former > >: " sun excess of YIN people that declines takes it, often causes the feeling of fullness of having loose bowels." 3. < < must join herbal > >: " stagnation of QI person forbidding." 4. < < book on Chinese herbal medicine just > >: " person not takes damp-phlegm.Stomach is received not prosperous person, also must keep away it."

Radix Astragali invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, diuresis, granulation promoting.For weak, the chronic diarrhea proctoptosis of the deficiency of vital energy, spontaneous perspiration, edema, sub-official's prolapsus, chronic nephritis proteinuria, diabetes, open sore part disunion of a specified duration.Decoction, 10～15g, heavy dose of 30～60g.QI invigorating invigorating middle warmer should be processed use; Use is given birth in other aspects more.Table excess pathogen is contained, retention of dampness due to stagnation of QI, food stagnation is stagnated, carbuncle from the beginning of or burst after the excess syndrome such as pyretic toxicity Shang Sheng, and hyperactivity of YANG due to deficiency of YIN person, must prohibit clothes.1. < < Collective Notes to Canon of Materia Medica > >: " dislike Carapax Et Plastrum Testudinis." 2. Xu Zhicai < < medicine is to > >: " dislike Carapax Et Plastrum Testudinis, Cortex Dictamni." 3. < < Elementary Medicine book on Chinese herbal medicine > >: " and grey black arrogant person's forbidding, prosperous person is also unavailable for table excess pathogen, and deficiency of YIN person also should lack use." " fear Radix Saposhnikoviae." 4. < < Bencao Jingshu > >: " and the real table of function, person does not use pathogenic factor in the exterior; Can help gas, QI excess person does not use; Can interiorly fill in, tonifying for the deficiency, chest and diaphragm is gas-tight asks, the intestines and stomach has stagnant person not use; Energy YANG invigorating, overabundance of YANG leading to deficiency of YIN person avoids it; Part of the body cavity above the diaphragm housing the heart and lungs intenseness of heat, part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels deficiency and coldness person avoids it; The many anger of patient, disharmony in liver-QI person do not take; Variola blood system heat is person's forbidding very." 5. < < medicineization justice > >: " if gas is had a surplus, pathogenic factor in the exterior is prosperous, and space between skin and muscles is real, and three warmers fire is moving, the ring that should break.To what apoplexy hands and feet caused by paralysis, expectorant is stopped up gas-tight, neither adds all the time." the 6. newly organized > > of < < book on Chinese herbal medicine: " hectic fever due to YIN-deficiency, consumptive disease heat are avoided use with the people of fullness in the epigastrium and abdomen." 7. < < book on Chinese herbal medicine converge bun > >: " anti-Rhizoma et radix veratri (Radix Rhizoma Veratri), fear Oletum Trogopterori, Radix Saposhnikoviae.”

Fructus Gardeniae heat clearing away, pathogenic fire purging, removing heat from blood.Control calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quenches one's thirst, conjunctival congestion, pharyngalgia, spits blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprains and swells and ache.1. < < herbal classic > >: " main five interior pathogens, pathogenic heat in the stomach gas, flushed complexion, wine bleb Zha nose, tuberculoid leprosy, red leprosy, skin infection." 2. < < Collective Notes to Canon of Materia Medica > >: " solution poison of walking to and for." 3. < < does not record > >: " treats also pain of order heat, and the breast heart, the large heat of intestine and small intestine are unhappy in the heart, pathogenic heat in the stomach gas." 4. < < property of medicine opinion > >: " Sha female ground beetle poison, the malicious wind that reduces phlegm and internal heat, sharp five types of stranguria; main attacked by pestiferous factors, diuresis, separates five kinds of jaundice; improving eyesight, disease heat extraction and the xerostomia of quenching one's thirst while controlling, conjunctival congestion and swelling pain." 5. < < Treatise on Dietetic Therapy > >: " main Dumb is mute, lichen planus, and the jaundice accumulated heat heart is hot-tempered." 6. < < medicine origin > >: " treats heart channel exopathogenic heat, except irritated, goes part of the body cavity above the diaphragm housing the heart and lungs deficiency-heat, controls wind." 7. < < medicine class on the analogy of natural things > >: " controls vexed regretful Nang and insomnia is wild utterly confused, stasis and dysuria." 8. Zhu Zhenheng: " rushes down three warmers fire, and clearing stomach gastral cavity blood, controls epigastric pain with cold limbs due to adverseness of heat, separates heat stagnation, row stagnation of QI." for oral administration: to decoct soup, 2～4 money; Or enter ball, loose.External: grind into powder and dress.Insufficiency of the spleen loose stool person avoids clothes.1. < < book on Chinese herbal medicine converges and says > >: " hematemesis and epistaxis, the non-YANG-fire person of breaking out avoids it." 2. < < must join herbal > >: " is evil in table, depletion fire syndrome going up, the two forbidding."

The Radix Linderae is pleasant, dissipating depression of QI, cold expelling, pain relieving.Control QI rising in reverse order chest and abdomen swelling and pain, dyspepsia does not disappear, and food is told in regurgitation, colic of cold type, beriberi, frequent micturition.1. < < Bencao Shiyi > >: " main attacked by pestiferous factors cardiac and abdominal pain, dyspepsia does not disappear, day row epidemic disease miasma, between bladder kidney, cold air is attacked punching back of the body backbone, married woman's vim and vigour, parasites in children's's abdomen." 2. < < Japan hanako materia medica > >: " controls all gas, and cold except all, food is told in cholera and regurgitation. dysentery, and carbuncle furuncle mange, and separate cold and hot." 3. Wang Haogu: " reason vigour." 4. < < detailed outline > >: " controls middle gas, beriberi, and hernia, emotional headache, swelling is panted, only frequent micturition and nebulousurine.The pent-up of " 5. < < explaining abstruseness of the canon of materia medica > >: " reason seven emotions, QI and blood is solidifying stops, and cholera is vomited and diarrhoea, and expectorant food is delaied." 6. the beautiful Chinese catalpa medicine of < < solution > >: " removing blood stasis with potent drugs is let out full, pain relieving relieving distension." for oral administration: to decoct soup, 1.5～3 money; Grind juice or enter ball, loose.The deficiency of vital energy, interior-heat person avoid clothes.1. < < Elementary Medicine > >: " evacuate a surname logical, be far more than Rhizoma Cyperi, can not take more." 2. < < Bencao Jingshu > >: " sick to be belonged to deficiency of vital energy person and avoids it." " married woman menses in advance, oliguria with reddish urine, and cough interior-heat, thirsty, xerostomia, tongue are bitter, insomnia, the disease of all yin asthenia generating intrinsic heat, neither should take." 3. < < herbal classic is met source > >: " invisible fire."

Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.< < property of medicine opinion > > carries it: monarch, and sweet in the mouth, pungent, nontoxic.Can main large migratory arthralgia, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken dyspepsia that disappears, appetizing, removes sputum, except cold and heat, lets out under only.Interarea light is happy, preserves youthful looks, and de-black.The swelling of harnessing the river is full, tells vomiting, and cold type of pain in abdomen is vomited and diarrhoea incessantly, and insufficiency of stomach-QI cold-dysentery.

Pericarpium Citri Reticulatae temperature; Pungent, bitter; Returning the bitter substance of spleen, lung meridian Pericarpium Citri Reticulatae to take limonin and bitter principle is representative " limonoid ", and this limonoid taste is gentle, soluble in water, contributes to the digestion of food.When Pericarpium Citri Reticulatae is used for cooking dishes.Its bitterness and other tastes are in harmonious proportion mutually, can form original in style local flavor.Pericarpium Citri Reticulatae contains the compositions such as volatile oil, hesperidin, vitamin B, C, and its contained volatile oil has gentle stimulation to gastrointestinal tract, and pneumatosis in intestinal tube is got rid of in secretion that can facilitating digestion liquid, increases appetite.Pericarpium Citri Reticulatae is also conventional Chinese medicine simply, has the greasy lasting of spleen invigorating, drying dampness to eliminate phlegm, solution of ventilation, the effect of stopping nausea and vomiting by lowering the adverse flow of QI.

Rhizoma Cimicifugae yang invigorating, delivers, rash, removing toxic substances.Control seasonal epidemic pathogens epidemic disease, headache cold and heat, laryngalgia, aphtha, macule is not saturating; Sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, women is collapsed, is with, uterus tenesmus; Carbuncle sore tumefacting virus.1. < < herbal classic > >: " principal solution hundred poison are warded off warm disease, barrier evil (makes " miasma pathogen ")." 2. < < does not record > >: " main attacked by pestiferous factors stomachache, seasonal epidemic pathogens poison pestilence, headache cold and heat, all poison of swelling due to wind, laryngalgia, aphtha." 3. < < property of medicine opinion > >: " controls little eclampsia, infantile convulsion, the hot disease of seasonal epidemic pathogens.Can control ability to speak wind and reveal swollen pain, root of the tooth floats rotten stench, pyretic toxicity pus and blood.Remove cardiopulmonary pathogenic wind toxic heat obstructed and constipated, aphtha, unhappiness.Treat carbuncle, smallpox, decocting silk floss is stained with and is wiped away in skin ulcer." 4. < < Japan hanako materia medica > >: " peace soul is determined soul, urticaria toxic swelling, and implication infantile malnutrition is hidden." 5. < < Decoction and Material Medica > >: " < < cures mainly secret formula > >: main consumptive lung disease spitting bloody pus, can send out antiperspirant floating." 6. < < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " table children's varioliform exanthema, separates sore, throat (swelling), the hoarseness of breathing with cough.Lung-heat, only toothache.Tonsillitis, mumps." 7. < < detailed outline > >: " speckle removing rash, the blood of committing theft, controls sun and falls into dizzy fortune, the empty pain of the breast side of body is heavy after chronic diarrhea dysentery, lose turbid, leukorrhagia, metrorrhagia, stranguria with blood, hematochezia, impotence cold foot." for oral administration: to decoct soup, 0.5～3 money; Or enter ball, loose.External: grind into powder and dress, decoct water rinsing the mouth or drip washing.Upper excess and lower deficiency, hyperactivity of fire caused by deficiency of YIN and measles thoroughly person are avoided clothes.1. < < Bencao Jingshu > >: " deficiency of YIN fire is moving for all haematemesis epistaxis, cough ant phlegm, and kidney channel is not enough, and QI rising in reverse order vomiting, and palpitation with fear palpitation with a distress feeling dementedly waits sickly, and method is salty avoids it." 2. < < must join herbal > >: " typhoid fever is the sick sun just, and varioliform exanthema is shown in mark, and lower unit is not enough, and deficiency of YIN fire is scorching, four forbiddings."

Herba Cistanches the kidney invigorating, benefit essence, moisturizes laxation.Control impotence in male, infertilitas feminis, leukorrhagia, metrorrhagia, chills and pain of the waist and kness, blood depletion constipation.1. < < herbal classic > >: " main five kinds of strain and seven kinds of impairment, invigorating middle warmer, except stem invasion by pathogenic cold burning pain, are supported the five internal organs, reinforcing YIN-essence, beneficial vital essence, Fu Ren mass in the abdomen." 2. < < does not record > >: " is except bladder pathogen, lumbago, dysentery relieving." 3. < < property of medicine opinion > >: " beneficial marrow, improving healthy complexion, prolongs life, and controls woman's metrorrhagia, tonifying YANG, large tonification, main also white under.It is out of fashion that " 4. < < Japan hanako materia medica > >: " controls male-sterilisation sun, and female is exhausted, and the moon does not produce, moistening five ZANG-organs, and longue meat, warm waist knee joint, man lets out essence, and hematuria is lost drop, leukorrhagia pain over the perineum." 5. < < Bencao Jingshu > >: " well-done food of Chinese liquor, punish-old people is the dry knot that closes just." for oral administration: to decoct soup, 2～3 money; Or enter pill.The weak loose stool of stomach, phase hyperactivity of fire person avoids clothes.1. < < book on Chinese herbal medicine covers bamboo fish trap > >: " avoid through ironware." 2. < < Bencao Jingshu > the >: " forbidding of having loose bowels, has heat in kidney, strong YANG transmission Xing Erjing admittedly person avoid it." 3. < < medicineization justice > >: " phase hyperactivity of fire, gastrointestinal weak person avoids use." 4. < < must join herbal > >; " avoid copper, ferrum.Fire is contained the flatulence of just closing, have a guilty conscience, all forbidding."

Radix Gentianae eliminating pathogen in the liver gallbladder excess-fire, except damp-heat in lower-JIAO.Treating the liver is through intenseness of heat, and infantile convulsion is manic, encephalitis B, and headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, carbuncle skin infection, scrotum swells and ache, pudendum pruritus due to damp pathogen.For damp and hot yellow cellulitis, swelling of the vulva pudendal pruritus, leukorrhagia, eczema pruritus, deafness, hypochondriac pain, bitter taste, convulsion with spasms.1. < < herbal classic > >; " continuous wound absolutely, determines the five internal organs, kills diseases due to noxious agents produced by various parasites for cold and heat between main bone, frightened lame pathogen." 2. < < does not record > >: ", except latent heat in stomach, seasonal epidemic pathogens is warm, and diarrhea of heat type diarrhea goes small worm in intestinal, the liver benefiting courage, and spasmolytic is cautious." 3. < < property of medicine opinion > >: " main pediatric epilepsy scared enters the heart, high fever bone heat, carbuncle; While controlling, disease heat is yellow, aphtha." 4. < < Japan hanako materia medica > >: " controls infantile convulsive seizure due to fright, infantile malnutrition gas, and calentura delirium, skin ulcer scabies, improving eyesight, only tired." 5. this sketch of < < footpath > >: " ancient prescription control subcutaneous ulcer multiplex it." 6. < < Lv Cliff rock book on Chinese herbal medicine > >: " controlled alcoholism and had blood in stool, discharging fresh blood stool." 7. < < medicine origin > the >: " conjunctival congestion of harnessing the Yellow River is swollen, inflammatory exophthalmos, and stasis of blood meat is raised, unbearably painful.< < cures mainly secret formula > > cloud: control the inferior portion's rheumatism and damp and hot, umbilicus swells and ache down to foot, the disturbance of lower legs due to pathogenic cold and dampness." 8. < < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " controlled and had sore throat, wash skin ulcer scabies poison swollen." 9. < < Elementary Medicine > >: " controls sudden onset of precordial pain, the worm pain of making a psychological attack, limbs pain." 10. < < detailed outline > >: " treats throat pain, wind heat night sweat.For oral administration: to decoct soup, 1～3 money; Or enter ball, loose.External: grind into powder smash deposited.Weakness of the spleen and stomach is let out and is avoided clothes without damp and hot excess-fire person.1. < < Leigong Paozhilun > >: " not on an empty stomach bait it, make us excessive and can't help." 2. < < Collective Notes to Canon of Materia Medica > >: " Rhizoma Osmundae makes for it.Dislike Radix Rehmanniae, Radix Peucedani japonici." 3. < < Japan hanako materia medica > >: " Semen Phaseoli is for making."

Radix Bupleuri reconciling superficies and interior, soothing the liver, yang invigorating.Control alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste is deaf, headache and dizziness, malaria, diarrhea proctoptosis, menoxenia, uterine prolapse.1. < < herbal classic > >: " stagnation of QI in main trusted subordinate's the intestines and stomach, diet gathers, and cold and heat pathogen, pushes away Chen Zhixin." 2. < < does not record > >: ", except dysphoria with smothery sensation under the typhoid fever heart, all expectorant accumulation of heats are real, evil contrary in the heart, faint breath between five Tibetan, and large intestine stops amassing, watery distension, and arthralgia chiefly caused by damp pathogen contracture.Also can bathe soup." 3. < < property of medicine opinion > >: " Zhi Relao arthralgia with restlessness, steam, shoulder and back ache, declares smooth vim and vigour, tired weakness and emaciation; The main therapeutic method to keep the adverse QI flowing downwards helps digestion, and when main, in disease, exterior-heat is not understood, and singly boils clothes." 4. < < prescriptions worth thousand gold > >: " Seedling juice is controlled deafness, fills with in ear.Painful abdominal mass in " 5. < < four tones of standard Chinese pronunciation books on Chinese herbal medicine > >: " main expectorant billows, the breast side of body." 6. < < Japan hanako materia medica > >: " mends five kinds of strain and seven kinds of impairment, relieving restlessness spasmolytic, physical strength profiting, expectorant antitussive, profit cardiopulmonary, add essence and mend marrow, the warm disease of it row is fanatical weary exhausted, and breast side of body fullness caused by stagnant QI is forgetful." 7. < < pearl sac > >: " removes alternate attacks of chills and fever, gallbladder numbness, and non-Radix Bupleuri mortise pin can not remove." 8. < < medicine origin > >: ", except asthenia dysphoria with smothery sensation, dismisses flesh heat, removes hectic fever in morning." 9. < < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " typhoid fever relieving the exterior syndrome by diaphoresis key medicine, move back the contact of the six channels pathogenic heat, numbness flaccidity, except liver man pathogenic heat, consumptive disease heat, the gas of the contrary knot of row Liver Channel, only left flank irritability pain, controls married woman's heat in blood and burns warp, can adjust menstruation.The tender stamen of " " diaphoresis, controls deficiency-heat, regulating menstruation root." 10. < < detailed outline > >: " controlled yang-energy and sunk, suppressing the hyperactive liver, gallbladder, three warmers, envelope be fire mutually, and headache, dizzy, blurred vision, swelling pain are hidden from view, deaf ring, all malarias, and lump at the left hypochondrium cold and heat, married woman's invasion of the blood-chamber by heat, irregular menstruation, children's's varioliform exanthema waste heat, the thin heat of five kinds of child malnutrition." for oral administration: to decoct soup, 0.8～1.5 money; Or enter ball, loose.Kidney-Yin loss, liver-yang ascensionist is avoided clothes.1. < < Collective Notes to Canon of Materia Medica > >: " Rhizoma Pinelliae makes for it.Dislike Fructus Gleditsia.Fear Herba Turczaninowiae Fastigiatae, Rhizoma et radix veratri (Radix Rhizoma Veratri).Under " 2. < < Elementary Medicine > >: " vigour, absolutely, YIN-fire hyperhidrosis person, wrongly takes and will certainly die." 3. < < Bencao Jingshu > >: " patient's void and gas lift person avoids it, person in vomiting and deficiency of YIN heated inflammation, method is avoided together.Malaria non-shaoyang channel person do not eat."

Folium Bambusae clearing heat and relieving fidgetness, the diuresis of promoting the production of body fluid.Control calentura excessive thirst, pediatric epilepsy scared, cough with dyspnea is told nosebleed, flushed complexion, oliguria also, erosion of the oral mucosa tongue boil.1. < < does not record > >: " the main heat of expectorant in the heart, cough with dyspnea." 2. < < property of medicine opinion > >: " main haematemesis pyretic toxicity wind, only quenches one's thirst." 3. < < Treatise on Dietetic Therapy > >: " main cough with dyspnea, quenches one's thirst, phlegm retention, sore throat, heat clearing away and restlessness relieving." 4. < < Japan hanako materia medica > >: " expectorant, controls fanatical unhappiness, and apoplectic aphasia in silence, high fever, headache wind syndrome of head, and cherish the pregnant number of people and revolve and fall down to the ground, spasmolytic is throbbed with fear, and pestilence fan is vexed, and pediatric epilepsy scared sky hangs." 5. Zhang Yuansu: " cool heart channel, beneficial vigour, heat extraction, slow spleen." 6. < < detailed outline > >: " decocts extract, gargles in tooth hemorrhagely, and eluting anus is not received." 7. the positive > > of < < book on Chinese herbal medicine: " irritated sleeplessness of reducing the asthenic fever, excessive thirst only, born fluid, Li little Shui, separates sore throat, and children's wind-heat infantile convulsion.The wind of breath liver and gall in " 8. < < Chongqing hall random notes > >: ", the heat of outer clear temperature administration, therefore there is the merit of the relieving convulsion of calming the nerves." 9. < < book on Chinese herbal medicine newer > >: " cool heart spleen invigorating, controls haematemesis, nose bleeding, hearing-improing and eyesight improving." for oral administration: to decoct soup, 2～4 money.

Fructus Rosae Laevigatae reinforcing the kidney and controlling nocturnal emission, reducing urination and antidiarrheal.Control spermatorrhea, the enuresis, frequent micturition, insufficiency of the spleen dysentery, the deficiency of the lung is breathed with cough, spontaneous sweating, bleeding not during menses.1. < < does not record > >: " stop spermatorrhea." 2. < < another name for Sichuan Province book on Chinese herbal medicine > >: " controls the splenic diarrhea dysentery, normal urination only, arresting seminal emission gas." 3. < < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " controls with the passing of time dysentery, metrorrhagia leukorrhagia, arresting seminal emission spermatorrhea." 4. the positive > > of < < book on Chinese herbal medicine: " emesis blood, epistaxis, born fluid, receive sweating due to debility, hold back asthenic fire, beneficial marrow, strengthening bone and muscle, mending five hides, the gas that nourishes blood, flat cough, Dingchuan is anxious, the palpitation with fear for the treatment of severe palpitation, stops the splenic diarrhea dysentery and little Shui and can't help." 5. < < Nanning City medicine will > >: " endured cream and controlled burn." for oral administration: to decoct soup, 1.5～3 money; Or enter ball, loose or endure cream.There are excess-fire, pathogenic heat person to avoid clothes.1. < < Elementary Medicine > >: " invasion by pathogenic cold has painful abdominal mass person to prohibit clothes." 2. < < Bencao Jingshu > >: " has loose bowels because burning hot spouting diarrhea person should not use; Incontinence of urine and vital essence slippage, because of in the deficiency of YIN heated person of obtaining, should not be used."

Corium Erinacei Seu Hemiechianus lowering the adverse-rising QI and relieving pain, cooling blood for hemostasis.Control regurgitation and tell food, stomachache hernia, hemorrhoidal hamorrhage anal fistula, seminal emission.1. < < herbal classic > >: " main five hemorrhoid erosion of the vulva hematochezia, red white multicolored blood juice is more than, and swelling of the vulva draws back bitterly, and wine boils and kills it.It is long-pending that " 2. < < does not record > >: " treats stomachache hernia, burns for ash, and wine takes it." 3. < < property of medicine opinion > >: " main hemorrhoidal hamorrhage rushes down blood, and hemorrhoid disease has head, and the person that is not recovered for many years processs the lower tool for weighing medicine in ancient China of the white drink in end; Burn end and blow main epistaxis.It is contrary that " 4. the Meng numerous: " ashing wine clothes are controlled stomach, again the only regurgitation of liquor clothes." 5. < < Bencao Beiyao > >: " rushes down removing heat from blood." 6. < < herbal classic is met former > >: " is except cataracta in order." 7. < < occupies diet spectrum > > with breath: " forged and ground clothes, controls seminal emission." for oral administration: to decoct soup, 2～3 money; Or enter powder.External: grind into powder and spread or dress.< < Collective Notes to Canon of Materia Medica > >: " obtain wine good.Fear Radix Platycodonis, Radix Ophiopogonis."

Placenta Hominis QI invigorating, nourishes blood, benefit essence.Control deficient, weakness and emaciation, consumptive fever hectic fever due to YIN-deficiency, cough with asthma, spitting of blood, night sweat, seminal emission, sexual impotence, women's vim and vigour are not enough, infertile or newborn few.1. < < Bencao Shiyi > >: " face snore skin is black for main vim and vigour weakness and emaciation, married woman's strain, all diseases thin worried person gradually in abdomen." 2. Wu's ball: " controls the deficient labor utmost point, epilepsy, and mental confusion is in a trance, feels at ease to nourish blood, and QI invigorating is mended essence." 3. < < book on Chinese herbal medicine covers bamboo fish trap > >: " treated all void and damaged in vain, and tuberculosis passes corpse, controls five kinds of strain and seven kinds of impairment, osteopyrexia and fever, and larynx is coughed hoarseness, and the thin dried and withered hairs of body is told nosebleed and is come red." 4. < < can approximately cure mirror > >: " ulna steams night sweat, and lumbago knee joint is soft, and the thin essence of body is withered, all can tonification." 5. < < book on Chinese herbal medicine newer > >: " strongly invigorating primordial QI, treating blood disorders divides, and training the mind is hindered nocturnal emission." 6. the modern Practical Chinese medicinal > of < < >: " is for neurasthenia, sexual impotence, infertile, again for paroxysmal pain is urged into agent and the agent of promotion galactopoiesis." 7. < < Shandong Chinese herbal medicine handbook > >: " prevention measles." for oral administration: to grind 0.8～1.5 money into powder; Or enter pill.

Limonitum is sweet, puckery, is slightly cold.Enter stomach, large intestine channel.Astringing intestine to stop diarrhea hemostasis.Control chronic diarrhea chronic dysentery, married woman's bleeding not during menses, anal fistula.1. < < herbal classic > >: " diarrhea is red white for main cough with dyspnea, cold and heat stuffy sensation with restlessness, and Xue Bi mass in the abdomen is warm greatly." 2. < < Leigong Paozhilun > >: " strengthening the spleen, peace visceral-qi." 3. < < does not record > >: " treats lower abdominal pain knot pain with irritability." " podomere is unfavorable, full greatly exhausted power heavy sensation of the body." 4. < < property of medicine opinion > >: " cures mainly metrorrhagia." 5. < < Japan hanako materia medica > >: " controls pathogen and arthralgia, the disease such as extremity are meciless, anal fistula." 6. < < detailed outline > >: " expedited the emergence of, Gu large intestine." 7. > > is wanted in the bun of < < medical center: " spleen reinforcing, holds back solid gastric qi, eliminating pathogen in the liver, blood stasis removing blood, thick large intestine." 8. the modern Practical Chinese medicinal > of < < >: " external is conspergative, controls ulcer.Coordinate him to plant antasthenic, make hematinic." for oral administration: to decoct soup, 3～5 money; Or enter ball, loose.External: grind into powder and spread or dress.Excess syndrome is avoided clothes, the careful clothes of anemia of pregnant woman.1. < < Collective Notes to Canon of Materia Medica > >: " Cortex Eucommiae makes for it.Fear Bulbus Fritillariae Uninbracteatae, Rhizoma Acori Graminei, pulvis ferri (ferrosic oxide)." 2. < < four tones of standard Chinese pronunciation books on Chinese herbal medicine > >: " Paeonia suffruticosa is for making." 3. < < book on Chinese herbal medicine converges and says > >: " dry disease of the empty blood of marrow is not used."

Radix Ilicis Asprellae nature and flavor: bitter sweet. cold.1. < < gathers medicinal herbs in the south of the Five Ridges and records > >: " bitter in the mouth." 2. < < Luchuan book on Chinese herbal medicine > >: " is sweet, cold." 3. < < Nanning City medicine will > >: " is sweet, flat, nontoxic." heat clearing away, promotes the production of body fluid, invigorates blood circulation, and removing toxic substances.Cure cold, have a headache dizzy, calentura is dry thirsty, eruptive disease, diarrhea of heat type, lung abscess, hemoptysis, laryngalgia, hemorrhoidal bleeding, gonorrhea, carbuncle poison, traumatic injury.1. the < < SHENGCAO property of medicine is for wanting > >: " kill Ci, reason traumatic injury." 2. < < gathers medicinal herbs in the south of the Five Ridges and records > >: " heat clearing away poison.Decoct herbal tea multiplex it.Control again sarcoptic mite." 3. < < Luchuan book on Chinese herbal medicine > >: " refreshing and detoxicating, the antidiarrheal of promoting the production of body fluid.Control calentura dryness of the mouth and thirst, diarrhea of heat type, general larynx disease." 4. < < Nanning City medicine will > >: " heat-clearing and toxic substances removing. lung moistening is quenched the thirst.Soothe sore throat thirsty, hemoptysis, eruptive disease." 5. the practical Chinese herbal medicine > of < < >: " treating acute tonsillitis, pharyngolaryngitis, pulmonary abscess, flu." pharmacological action: have the effect that increases coronary flow, strengthens contractile force with the dirty perfusion Flos Ilicis Asprellae of guinea-pig heart injection; On the electrocardiogram of the acute myocardial ischemia causing with pituitrin rabbit, the change of T ripple (towering) is had to protective effect, S-T field offset and rhythm disturbance also have certain minimizing.

Embodiment 1 pill

The manufacturing process of the present invention's honey refining pill is: get Ootheca Mantidis 1000g, Fructus Schisandrae Chinensis 1000g, RHIIZOMA DIOSCOREAE fr0m Henan of China 1000g, Semen Cuscutae 1000g, Radix Codonopsis 1000g, Fructus Psoraleae 1000g, Fructus Corni 1000g, Rhizoma Polygonati 1000g, Radix Astragali 1000g, Fructus Gardeniae 1000g, Radix Linderae 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Pericarpium Citri Reticulatae 1000g, Rhizoma Cimicifugae 1000g, Herba Cistanches 1000g, Radix Gentianae 1000g, Radix Bupleuri 1000g, Folium Bambusae 1000g, Fructus Rosae Laevigatae 1000g, Corium Erinacei Seu Hemiechianus 1000g, Placenta Hominis 1000g, Limonitum 1000g and Radix Ilicis Asprellae 1000g; Medical material is soaked 30 minutes to 1 hour, and heated and boiled 30 minutes, filters filtrate for later use; Filtering residue adds water, and heating, boils 30 minutes for the second time, refilters filtrate for later use; Filtering residue adds water again, and heated and boiled is 30 minutes for the third time, filters; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, is controlled at 75 ℃, is cooled to be Powderedly twisted into slice together with being mixed in right amount with Mel after oven dry; Every 5g of take packs as a ball wax seal.

Embodiment 2 capsules

The manufacturing process of capsule of the present invention is: get Ootheca Mantidis 1800g, Fructus Corni 1000g and Fructus Psoraleae 1000g, the water soaking 1-2 hour that adds 5-10 doubly to measure, extracts the volatile oil of 2-5 hour, can steam distillation, supercritical fluid extraction.Collect volatile oil, medicinal liquid filters, standby, medicinal residues and other crude drug Fructus Schisandrae Chinensis 1000g, Semen Cuscutae 1000g, RHIIZOMA DIOSCOREAE fr0m Henan of China 1000g, Radix Codonopsis 1000g, Rhizoma Polygonati 1000g, Radix Astragali 1000g, Fructus Gardeniae 1000g, Radix Linderae 1000g, Rhizoma Atractylodis Macrocephalae 1200g, Pericarpium Citri Reticulatae 1000g, Rhizoma Cimicifugae 1500g, Herba Cistanches 1000g, Radix Gentianae 1300g, Radix Bupleuri 1000g, Folium Bambusae 1000g, Fructus Rosae Laevigatae 1200g, Corium Erinacei Seu Hemiechianus 1000g, Placenta Hominis 1000g, Limonitum 1000g and Radix Ilicis Asprellae 1000g, add 60-90% ethanol, soak 0.5-1.5 hour, extract twice, each 1-2 hour, adding for the first time 5-10 doubly measures, adding for the second time 5-10 doubly measures, merge extractive liquid, filter, above two filtered solutions merge to filter, and when filtered solution is evaporated to relative density and is 80 ℃, 1.10-1.50 precipitate with ethanol twice, adjusts concentration of alcohol to 60%-90%, get supernatant concentration to relative density 1.10-1.50 while being 80 ℃.Can adopt membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation, macroporous resin method.Get above-mentioned extractum, the volatile oil and the vegetable oil that add step a to obtain, the addition of vegetable oil accounts for the 2-5% of extractum and volatile oil gross mass, mix, with colloid mill, grind 10 minutes, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.

Embodiment 3 tablets

Method for preparing tablet thereof of the present invention: get Ootheca Mantidis 1500g, Fructus Schisandrae Chinensis 1500g, RHIIZOMA DIOSCOREAE fr0m Henan of China 1500g, Semen Cuscutae 1500g, Radix Codonopsis 1200g, Rhizoma Polygonati 1500g, Fructus Corni 1600g, Fructus Psoraleae 1500g, Radix Astragali 1700g, Fructus Gardeniae 1200g, Radix Linderae 1500g, Rhizoma Atractylodis Macrocephalae 1200g, Pericarpium Citri Reticulatae 1500g, Rhizoma Cimicifugae 1500g, Herba Cistanches 1500g, Radix Gentianae 1500g, Radix Bupleuri 1500g, Folium Bambusae 1500g, Fructus Rosae Laevigatae 1700g, Corium Erinacei Seu Hemiechianus 1500g, Placenta Hominis 1500g, Limonitum 1200g, Radix Ilicis Asprellae 1700g; First medical material is put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 45 minutes, extract active ingredient, 2 extracting solution are merged standing.Medicinal residues are added to 10 times of water gagings, heating and refluxing extraction 3 times, each 1 hour, merges 3 extracting solution again; Merge above-mentioned two kinds of extracting solution, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, the relative density of filtrate is about 1.06 (20 ℃); The macroporous adsorptive resins that above-mentioned filtrate is 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicinal liquid; Add starch to be pressed into tablet.

Embodiment 4 enemas

The preparation method of enema of the present invention: get Ootheca Mantidis 1500g, Fructus Schisandrae Chinensis 1500g, RHIIZOMA DIOSCOREAE fr0m Henan of China 1500g, Semen Cuscutae 1500g, Radix Codonopsis 1700g, Rhizoma Polygonati 1500g, Fructus Corni 1600g, Fructus Psoraleae 1500g, Radix Astragali 1500g, Fructus Gardeniae 1200g, Radix Linderae 1200g, Rhizoma Atractylodis Macrocephalae 1200g, Pericarpium Citri Reticulatae 1500g, Rhizoma Cimicifugae 1500g, Herba Cistanches 1700g, Radix Gentianae 1500g, Radix Bupleuri 1200g, Folium Bambusae 1500g, Fructus Rosae Laevigatae 1200g, Corium Erinacei Seu Hemiechianus 1500g, Placenta Hominis 1500g, Limonitum 1700g, Radix Ilicis Asprellae 1500g, soak 30 minutes to 1 hour, heated and boiled 30～40 minutes, filter, filtrate for later use, filtering residue adds water and heats for the second time, boils 30～40 minutes, filters filtrate for later use, filtering residue adds water again, and heated and boiled is 30～40 minutes for the third time, filters, three filtrates are combined, and heating is concentrated into pasty state medicinal liquid.

Also after can directly decocting, make enema.

During use, get enema 100 mL～200 mL, retention enema, pour into 30mL～50 mL at every turn, with No. 12 oxygen catheters and 50 mL syringes, slowly inject, retain medicinal liquid and be advisable with 10 min, insertion depth is 15 cm～20 cm, 2～3 times/d, 7d is 1 basic course for the treatment of, each 20 min-40 min.

Also the mixed vaseline furnishing paste of concentrated medicinal liquid can be spread out on oilpaper or rubber paste, stick abdominal part or umbilicus place.Make patch and stick abdominal part or umbilicus place.Umbilicus, cave name Shenque, for the important acupuncture point of conception vessel, Gu has saying of " Shenque, curing mainly all kinds of diseases and ailments, and old man, empty people have loose bowels as god ", position, umbilicus place is again that chong channel is through row part, Conception Vessel and Governor Vessel is the exterior and the interior each other, and commander's human body is all through hundred arteries and veins, therefore umbilical part is maintained close ties with by above meridians and all internal organs organs of whole body.Children's's skin is tender, and stomach wall is thin, and local application is easy to absorb, and no pain, and external application of Chinese medicine Shenque can reach dispelling cold and activating YANG, regulating QI to relieve pain, rapidly the merit of dysentery relieving disease.

Pharmacology pharmacodynamic experiment:

1, cumulative toxicity test report

Test method: select 20 healthy mices, female, male each 10, the capsule of the embodiment of the present invention 2 of take is object, it is first phase that dosage designs every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, and the LD 50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjust dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose, to tested material after 20 days, female, buck all occurs without death condition.

2, acute toxicity test: the pill of the embodiment of the present invention 1 of take is object, gives white mouse large enteral dispensing, observes 7 for 150 times of clinical consumption per day.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.White mouse vagina and damaged skin are carried out to irritation test, there are no irritative response and other untoward reaction.Toxicity test proves, the not toxic effect of this medicine and untoward reaction, and clinical practice is safe and reliable

3, the bacteriostasis to common bacterial strain

Solid process antibacterial action: line on blood ware or ordinary nutrient agar plate so that various test organismss are intensive, with 8mm card punch, punch, every hole adds the about 0.2ml of aseptic reagent, at 37 ℃, cultivate 18～24 hours, observe the size of inhibition zone, the tablet of the embodiment of the present invention 3 of take is example, judges that its responsive result is as following table.

Bacterial strain	Strain number	100% tablet	200% tablet	300% tablet
					Staphylococcus aureus	M122	--	+++	+++
Staphylococcus albus	M121	-	++++	++++
					Bacillus pyocyaneus	Ps207	-	++	+++
Bacillus proteus	E402	+?	++	+++
					Escherichia coli	E100	-	++	++
Bacillus subtilis	63051	+	+++	++
					Diphtheria corynebacterium	C102	+	+++	++++
Diplococcus pneumoniae	M311	-	+++?	+++
					Bacillus typhi	E686	++	+++	++++
Paratyphoid bacillus A	50073	++	+++	+
					Bacillus paratyphosus B	50094	+	++?	++++
Beta hemolysis streptococcus	M220	++	++++	+++

Antibacterial circle diameter < 9mm., drug resistance-; Antibacterial circle diameter >=10～14mm, slight sensitive+; Antibacterial circle diameter >=15～19mm, medium sensitivity++; Antibacterial circle diameter >=20～29mm, extremely sensitive +++; Antibacterial circle diameter >=30mm, special extremely sensitive ++++.

Above extracorporeal bacteria inhibitor test shows, the tablet of the embodiment of the present invention 3 truly has obvious inhibitory action to common antibacterial.

4. hypersensitive test:

Get 18 of healthy albino guinea-pigs, body weight 250-300g, male and female dual-purpose, rejects both sides dorsal body setae before test, and every side 3 * 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration.The enema 0.1g that gets the embodiment of the present invention 4 is applied to unhairing district, back, the next day 1 time, totally 3 times.In last, contact latter 14 days, at back the same area, smear this product 0.1g, after 6h, remove after medicine and at once observe, and in 24,48,72h observes and has or not anaphylaxis.Blank group is used same method to excite with positive controls and is contacted and observe.Result of the test: localized erythema and slight edema appear in positive controls animal skin after 1 hour in sensitization, within 24 hours, symptoms of allergic increases the weight of, and there is scleroma to form, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.

Clinical data

1, data and method

1.1 physical data: during selecting in March, 2010-2011 year February, the enuresis infant of my institute's diagnosis and treatment is totally 200 examples, all meet the diagnostic criteria of the children enuresis that international children's's urinary continence association (ICCIS) announced in 1998.Wherein, male 138 examples, female's 62 examples, 5 years old age person, 40 examples, 6-9 year person 151 examples, 10 years old above 9 example.Clinical manifestation be 5 years old whatever amount child monthly at least wets the bed twice, 6 years old and above child monthly at least wets the bed once, basic each urine amount all can be drenched sheet.Be divided at random two groups, treatment group 128 examples, matched group 72 examples.Two groups of infants comparing difference not statistically significant aspect age, sex, state of an illness weight, has comparability, and according to the weight out-patient treatment of the state of an illness.

1.2 criterion of therapeutical effect

Clinical recovery: enuresis symptom is alleviated completely, nothing recurrence in half a year; Effective: enuresis number of times obviously reduces, in sleep, can wake and urinate; Invalid: enuresis symptom is without improvement.

1.3 Therapeutic Method and therapeutic effect

1.3.1 treatment group is four treatment group 1-4 at random, uses respectively the Chinese medicine composition of the different preparations of embodiment of the present invention 1-4 to treat:

(1) treatment group 1:32 example infant is used the pill of embodiment 1,2 times on the one, take 1 for 1 time, within 7 days, be a course for the treatment of, use continuously after 1-3 the course for the treatment of, drug withdrawal further consultation again in 2 weeks, statistics discovery 20 routine infants are all fully recovered, and 8 routine infants obviously improve, 4 routine infants are invalid, during treatment, do not find other side effect that medicine brings, follow up a case by regular visits to half a year, all without any the symptom recurring.

(2) treatment group 2:32 example infant is used the capsule of embodiment 2,3 times on the one, take 1-2 grain 1 time, within 7 days, be a course for the treatment of, use continuously after 1-3 the course for the treatment of, drug withdrawal further consultation again in 1 week, statistics discovery 26 routine infants are all fully recovered, and 5 routine infants obviously improve, 1 routine infant is invalid, during treatment, do not find other side effect that medicine brings, follow up a case by regular visits to half a year, all without any the symptom recurring.

(3) treatment group 3:32 example infant is used the tablet of embodiment 3,3 times on the one, take 1-2 sheet 1 time, within 7 days, be a course for the treatment of, use continuously after 1-3 the course for the treatment of, drug withdrawal further consultation again in 1 week, statistics discovery 23 routine infants are all fully recovered, and 6 routine infants obviously improve, 3 routine infants are invalid, during treatment, do not find other side effect that medicine brings, follow up a case by regular visits to half a year, all without any the symptom recurring.

(4) treatment group 4:32 example infant is used the enema of embodiment 4,2-3 time on the 1st, within 7 days, be a course for the treatment of, coloclysis 1-2 is after the course for the treatment of continuously, and drug withdrawal carrys out further consultation for 1 week again, statistics discovery 24 routine infants are all fully recovered, 6 routine infants obviously improve, and 2 routine infants are invalid, do not find other side effect that medicine brings during treatment, follow up a case by regular visits to half a year, all without any the symptom recurring.

1.3.2 matched group is divided into three matched group 1-3 at random, uses respectively different Western medicine to treat:

(1) matched group 1:24 example infant is used acetic acid deammoniation pressurization rope sheet, and a 150g, 3 times on the one, is used after 3 months continuously, drug withdrawal further consultation again in 1 week, statistics is found 11 routine infant recoveries from illness, 6 routine infants obviously improve, 7 routine infants are invalid, follow up a case by regular visits to half a year, and statistics recurs after finding wherein there are 9 routine drug withdrawals.

(2) matched group 2:24 example infant is taken oxibutynin sheet, and a 2.5-5mg, every day 2-3 time, takes after 1 month continuously, drug withdrawal further consultation again in 1 week, statistics is found 9 routine infant recoveries from illness, 7 routine infants obviously improve, 8 routine infants are invalid, follow up a case by regular visits to half a year, and statistics is found wherein after 8 routine drug withdrawals, to recur; When taking, there is the side effect such as constipation, dyspepsia in other 7 examples.

(3) matched group 3:24 example infant is taken meclofenoxate tablet, and a 0.01g, every day 3 times, takes after 1 month continuously, drug withdrawal further consultation again in 1 week, statistics is found 8 routine infant recoveries from illness, 7 routine infants obviously improve, 9 routine infants are invalid, follow up a case by regular visits to half a year, and statistics finds there is recurrence disease after 6 routine drug withdrawals; When taking, there is the side effect such as headache, insomnia in other 5 examples.

Known by above-mentioned clinical trial: compare with traditional Western medicine for the treatment of bed-wetting, the Chinese medicine composition of embodiment of the present invention 1-4 has advantages of that healing time is short, cures rear difficult recurrence and have no side effect.

2, concrete case

Case 1: land, man, 5 years old half, on average wet the bed 2-4 time weekly, use the enema of the embodiment of the present invention 4 to carry out enema treatment, pour into 30mL～50 mL at every turn, with No. 12 oxygen catheters and 50 mL syringes, slowly inject, retaining medicinal liquid is advisable with 10 min, insertion depth is 15 cm～20 cm, 2～3 times/d, and each 20 min-40 min, 7d is 1 basic course for the treatment of, treat 2 courses for the treatment of, the number of times of wetting the bed during treatment takes a turn for the better gradually, and after two courses for the treatment of, the phenomenon of wetting the bed does not appear for 1 week in drug withdrawal, follow up a case by regular visits to half a year, without recurrence symptom.

Case 2: poplar, man, 7 years old, monthly on average wet the bed 5-6 time, use the tablet of the embodiment of the present invention 3,3 times on the one, take 1 for 1 time, within 7 days, be a course for the treatment of, use continuously after 2 courses for the treatment of, drug withdrawal further consultation again in 1 week, in 1 week, there is not bed-wetting phenomenon in drug withdrawal, during treatment, do not find other side effect that medicine brings, follow up a case by regular visits to half a year, without any the symptom of recurrence.

Case 3: grandson, female, 6 years old, monthly on average wet the bed 4-6 time, use the capsule of the embodiment of the present invention 2,3 times on the one, taking 2 for 1 time, 7 days is a course for the treatment of, uses continuously after 1 half course for the treatment of, drug withdrawal further consultation again in 1 week, the number of times of wetting the bed after 1 course for the treatment of obviously reduces, and drug withdrawal is anuria bed phenomenon during 1 week, does not find other side effect that medicine brings during treatment, follow up a case by regular visits to half a year, without any the symptom of recurrence.

Case 4: paddy, man, 9, monthly on average wet the bed 7-8 time, have obvious inferiority complex, use the pill of the embodiment of the present invention 1,2 times on the one, take 1 for 1 time, within 7 days, be a course for the treatment of, use continuously after 3 courses for the treatment of, drug withdrawal further consultation again in 1 week, the number of times of wetting the bed after 1 course for the treatment of obviously reduces, drug withdrawal is anuria bed phenomenon during 1 week, during treatment, do not find other side effect that medicine brings, follow up a case by regular visits to half a year, without any the symptom of recurrence.

Claims (7)

1. a Chinese medicine preparation for the treatment of bed-wetting, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of various crude drug is: 10～20 parts of Ootheca Mantidiss, 10～20 parts of Fructus Schisandrae Chinensis, 10～25 parts of RHIIZOMA DIOSCOREAE fr0m Henan of China, 10～25 parts of Semen Cuscutae, 10～20 parts of Radix Codonopsis, 10～25 parts of Fructus Psoraleaes, 10～30 parts of Fructus Corni, 10～20 parts of Rhizoma Polygonatis, 10～25 parts of the Radixs Astragali, 10～20 parts of Fructus Gardeniae, 10～20 parts of the Radixs Linderae, 10～25 parts of the Rhizoma Atractylodis Macrocephalaes, 10～25 parts of Pericarpium Citri Reticulataes, 10～30 parts of Rhizoma Cimicifugaes, 10～30 parts of Herba Cistanches, 10～30 parts of Radix Gentianaes, 10～30 parts of Radix Bupleuri, 10～20 parts, Folium Bambusae, 10～20 parts of Fructus Rosae Laevigatae, 10～20 parts of Corium Erinacei Seu Hemiechianuss, 10～20 parts of Placenta Hominiss, 10～20 parts of 10～20 parts of Limonitum and Radix Ilicis Asprellaes.

2. the Chinese medicine preparation for the treatment of bed-wetting according to claim 1, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of each crude drug is: 10～20 parts of Ootheca Mantidiss, 10～15 parts of Fructus Schisandrae Chinensis, 10～25 parts of RHIIZOMA DIOSCOREAE fr0m Henan of China, 15～25 parts of Semen Cuscutae, 10～20 parts of Radix Codonopsis, 10～20 parts of Fructus Psoraleaes, 10～20 parts of Fructus Corni, 10～15 parts of Rhizoma Polygonatis, 10～20 parts of the Radixs Astragali, 10～15 parts of Fructus Gardeniae, 10～20 parts of the Radixs Linderae, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Pericarpium Citri Reticulataes, 15～20 parts of Rhizoma Cimicifugaes, 10～20 parts of Herba Cistanches, 10～20 parts of Radix Gentianaes, 15～30 parts of Radix Bupleuri, 10～20 parts, Folium Bambusae, 15～20 parts of Fructus Rosae Laevigatae, 10～20 parts of Corium Erinacei Seu Hemiechianuss, 15～20 parts of Placenta Hominiss, 10～20 parts of 10～15 parts of Limonitum and Radix Ilicis Asprellaes.

3. the Chinese medicine preparation for the treatment of bed-wetting according to claim 1, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of each crude drug is: 10～15 parts of Ootheca Mantidiss, 14～20 parts of Fructus Schisandrae Chinensis, 10～20 parts of RHIIZOMA DIOSCOREAE fr0m Henan of China, 15～20 parts of Semen Cuscutae, 15～20 parts of Radix Codonopsis, 15～20 parts of Fructus Psoraleaes, 10～20 parts of Fructus Corni, 15～20 parts of Rhizoma Polygonatis, 15～25 parts of the Radixs Astragali, 15～20 parts of Fructus Gardeniae, 10～15 parts of the Radixs Linderae, 15～25 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Pericarpium Citri Reticulataes, 10～30 parts of Rhizoma Cimicifugaes, 15～30 parts of Herba Cistanches, 15～30 parts of Radix Gentianaes, 10～20 parts of Radix Bupleuri, 10～20 parts, Folium Bambusae, 10～16 parts of Fructus Rosae Laevigatae, 10～20 parts of Corium Erinacei Seu Hemiechianuss, 10～15 parts of Placenta Hominiss, 15～20 parts of 13～20 parts of Limonitum and Radix Ilicis Asprellaes.

4. a preparation method for the Chinese medicine preparation of the treatment bed-wetting as described in claim 1-3 any one, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and described preparation method comprises the following steps:

A, get Ootheca Mantidis, Fructus Psoraleae, Herba Cistanches and Rhizoma Polygonati, the water soaking 1-2 hour that adds 5-10 doubly to measure, extracts the volatile oil of 2-5 hour, collects volatile oil, and medicinal liquid filters, and medicinal residues are standby;

B, get Fructus Schisandrae Chinensis, RHIIZOMA DIOSCOREAE fr0m Henan of China, Semen Cuscutae, Radix Codonopsis, Fructus Corni, the Radix Astragali, Fructus Gardeniae, the Radix Linderae, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Cimicifugae, Radix Gentianae, Radix Bupleuri, Folium Bambusae, Fructus Rosae Laevigatae, Corium Erinacei Seu Hemiechianus, Placenta Hominis, Limonitum and Radix Ilicis Asprellae, mix with the medicinal residues of described step a, add 60%-90% ethanol, soak 0.5-1.5 hour, extract twice, each 1-2 hour, adding for the first time 5-10 doubly measures, add for the second time 5-10 and doubly measure, merge extractive liquid,, filters; 1.10-1.50 when concentrating filtrate to relative density and being 80 ℃, precipitate with ethanol twice, adjusts concentration of alcohol to 60%-90%, gets supernatant concentration to relative density 1.10-1.50 while being 80 ℃, obtains extractum;

C, get above-mentioned extractum, the volatile oil and the vegetable oil that add step a to obtain, the addition of vegetable oil accounts for the 2-5% of extractum and volatile oil gross mass, mix, with colloid mill, grind 10 minutes, constantly stir, be cooled to room temperature, described Chinese medicine preparation is incapsulated in housing, obtain described capsule.

5. the preparation method of the Chinese medicine preparation for the treatment of bed-wetting according to claim 4, is characterized in that, in described step a, the extraction of Ootheca Mantidis, Fructus Psoraleae, Herba Cistanches and the contained volatile oil of Rhizoma Polygonati, is steam distillation or supercritical fluid extraction.

6. the preparation method of the Chinese medicine preparation for the treatment of bed-wetting according to claim 4, is characterized in that, in described step b, described extraction adopts membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation or macroporous resin method.

7. the preparation method of the Chinese medicine preparation of the treatment bed-wetting as described in claim 1-3 any one, it is characterized in that, described Chinese medicine preparation is enema, described preparation method comprises the following steps: all described crude drug are soaked 30 minutes to 1 hour, heated and boiled 30～40 minutes, filter filtrate for later use; Filtering residue adds water and heats for the second time, boils 30～40 minutes, filters filtrate for later use; Filtering residue adds water again, and heated and boiled is 30～40 minutes for the third time, filters; Three filtrates are combined, and heating is concentrated into pasty state medicinal liquid.