CN105055904A - Chinese herbal preparation for treating chronic non-atrophic gastritis and preparation method thereof - Google Patents
Chinese herbal preparation for treating chronic non-atrophic gastritis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese herbal preparation for treating chronic non-atrophic gastritis. The Chinese herbal preparation comprises coastal glehnia roots, ophiopogon japonicus, angelica sinensis, rehmannia roots, wolfberry fruits, szechwan Chinaberry fruits, white paeony roots, honey-fried licorice roots, pearl powder, oyster, cuttlebone, mangnolia officinalis, flos rosae rugosae, fingered citron, semen cannabis, snake gourd seeds, dendrobium nobile, rhizoma anemarrhenae, coptis chinensis, rhodobryum roseum, slug and melastoma dodecandrum roots. The Chinese herbal preparation is effective in nourishing yin, tonifying the stomach, nourshing the blood, regulating the flow of vital energy, regulating the middle warmer, relieving pains, improving the protective capability of gastric mucosa, promoting the gastrointestinal motility, relaxing bowels and improving the immune function of the organism; the preparation is simple in prescription, simple and convenient in fabricating process, safe, little in toxic and side effect, low in cost, capable of reaching the focus directly, short in cure time, not prone to getting relapse and the like.
Description
Technical field
The present invention relates to field of traditional Chinese medicine pharmacy, particularly a kind ofly treat Chinese medicine preparation of chronic non-atrophic gastritis and preparation method thereof.
Background technology
Chronic non-atrophic gastritis is gastral commonly encountered diseases, it is generally acknowledged the gastric mucosa inflammation referring to any cause of disease and cause, often with epithelial damage and cell regeneration.The reaction of gastric mucosa to infringement relates to the processes such as epithelial damage (damage), mucosal inflammation (inflammation) and re-epithelilization (regeneration).
The sorting technique of new Sydney system (UpdateSydneysystem) is in the world adopted in the Chinese National Consensus on Chronic Gastritis that China reaches for 2006, change according to histopathology and pathological changes at the Germ distribution of stomach, in conjunction with the possibility cause of disease, chronic gastritis is divided into non-atrophic (in the past claiming shallow, non-atrophic), atrophic (atrophic) and specific type (specialforms) three major types.
Chronic non-atrophic gastritis refer to without Mucosal atrophy sexually revise, gastric mucosa layer is shown in based on the chronic gastritis of the chronic inflammatory cell infiltration of lymphocyte and plasma cell.According to the position of inflammation distribution, gastric antrum gastritis, body of stomach gastritis and full gastritis can be further divided into.First there is gastric antrum gastritis in helicobacter pylori infections, be then full gastritis to stomach proximal spread gradually, whether full gastritis develops and develop speed and there is obvious individual variation and regional difference; The chronic gastritis main manifestations that autoimmune causes is body of stomach gastritis.Autoimmune gastritis is common in Northern Europe, only has minority to report in China.Then different because of the popularity of country variant, different regions helicobacter pylori infections by helicobacter pylorus microbial chronic gastritis popularity.Helicobacter pylori infections is world wide distribution, and general Helicobacter Pylori Infection Rate developing country is higher than developed country, and infection rate increases with the age and raises, and difference between male is little.China belongs to helicobacter pylori height infection rate country, and in estimation crowd, Helicobacter Pylori Infection Rate is about 45% ~ 70%.People is the helicobacter pylori source of infection be uniquely identified at present.It is generally acknowledged that being broadcast by the mouth mouth of interpersonal close contact or excrement oral instructions is the main route of transmission of helicobacter pylori.The display of epidemiological study data is backward in economy, living environment is poor and bad health habit and Helicobacter Pylori Infection Rate are proportionate.Because helicobacter pylori infections causes gastric mucosa inflammation with few exceptions, after infecting, body is generally difficult to removed and become chronic infection, and the chronic gastritis prevalence that therefore in crowd, helicobacter pylori infections causes is parallel with the infection rate of this crowd's helicobacter pylori.But the prevalence of the chronic many stoves atrophic gastritis developed by helicobacter pylori infections then might not be parallel with the Helicobacter Pylori Infection Rate of crowd, and be often parallel relation with the gastric cancer prevalence of locality.On the whole, helicobacter pylori infections, diet and environmental factors, autoimmune and other factors, as entered stomach containing the Duodenal reflux of bile and pancreatic juice during sphincter of pylorus functional defect, can weaken gastric mucosal barrier function; Other extrinsic factors, as excessive drinking, take the medicines such as NSAID, some irritable food etc. and all repeatedly can damage gastric mucosa.In theory these factors all can separately or with helicobacter pylori infections synergism and cause or increase the weight of gastric mucosa chronic inflammatory disease, but still lack the evidence of systematic study at present.The process of chronic gastritis is the chronic process of mucosal lesion and reparation, and Main Tissues pathological characteristics is that inflammation, atrophy and intestinalization are raw.Inflammation shows as mucous layer based on the chronic inflammatory cell infiltration of lymphocyte and plasma cell, and the common lymph follicle of the microbial chronic gastritis of helicobacter pylorus is formed.Showing Active inflammation when seeing and having neutrophil infiltration, be called chronic active gastritis, there is helicobacter pylori infections in many promptings.Different in the distribution of gastric at the above-mentioned pathological change of dissimilar gastritis.The microbial chronic gastritis of helicobacter pylorus, inflammation diffusivity distributes, but attaches most importance to gastric antrum.Asymptomatic by helicobacter pylorus microbial chronic gastritis most of patients; The indigestion symptom such as have symptom to show as upper abdominal pain or discomfort, big belly, early full, belch, to feel sick, the endoscopic findings of have that it's too late the order of severity and the chronic gastritis of these symptoms and tissue pathologies change there is no the dependency autoimmune gastritis patient of affirmative can with anemia, also can with other clinical manifestations of vitamin B12 deficiency except anemia when typical pernicious anemia.Gastroscopy also gets the most reliable method that living tissue is diagnosing chronic gastritis as histopathologic examination simultaneously.The visible erythema of non-atrophic gastritis (point, lamellar or strip), the coarse injustice of mucosa, petechia/speckle, mucosa edema under scope, the basic expressions such as to ooze out.Should detect blood PCA and IFA suspected of autoimmune gastritis person, as being positive for this sick PCA, during companion's pernicious anemia, IFA is positive more more.Serum Vitamin Blz concentration determination and vitamin B, z absorption test helps pernicious anemia diagnosis.Stomachache, also known as gastric abscess.The traditional Chinese medical science thinks that stomachache is due to gastric qi retardance, stomach network stasis blocking, and stomach is become homeless foster, a kind of taste enteropathy card being primary symptom with upper abdomen gastral cavilty portion generation pain that stagnation of QI and blood may bring about pain causes.In classic doctor's nationality to the discussion of primary disease first appeared in "Nei Jing".As " Plain Questions, hexa-atomic just discipline discusses a section greatly " meaning: " strongly fragrant the sending out of wood ... people's disease epigastralgia right below the heart, above prop up two sides of body, diaphragm is swallowed not bitterly, aphagia." " Plain Questions the most pure virginity will discuss a section greatly " also say: " the nether world sky of fainting, wind is excessive to be won, the sick epigastralgia right below the heart of the people." illustrating that stomachache and wood gas win partially, liver stomach is become estranged relevant." Plain Questions lifts a pain opinion section " has also elucidated cold-evil's invasion, causes stagnation of QI-blood obstructed and makes the mechanism of having a stomachache." Treatise on Febrile Diseases: distinguish that JUE YIN syndrome arteries and veins is demonstrate,proved and controls " is said: " the moon of fainting for sick, quench one's thirst, QI bumping upward against the heart, heat and pain in the epigastrium, hungry and loss of appetite, eats then vomiting ascaris, purgation, continuous diarrhea." " ache in the heart " wherein, be namely stomachache, this is for distinguishing that controlling coldheat complex has a stomachache and provide useful reference later age." Prescriptions for Succouring the Sick stomachache door " cause of disease to stomachache has done more comprehensive discussion: and nine types of precordial pain " though name is different, and all because of diseases caused by exogenous pathogenic factor caused by it, inside prevent seven emotions; or raw and cold fruit and so on eaten by drink, makes pathogen fight in healthy energy, heresy is orthogonal hits; Airway obstruction, strongly fragrant in middle Jiao, then becomes pained ".Jin and Yuan dynasty, " secret record of the orchid chamber, volume two " vertical " gastric abscess ", its pathogenesis of opinion, then polyphyly improper diet and overtiredness and cause the void of taste, caused by cold-evil hinders again.Its method for the treatment of of opinion, the not outer QI invigorating of main points, warming middle-JIAO, regulate the flow of vital energy, stomach function regulating etc." danxi's experiential therapy heart splenalgia " is called: " heart diaphragm pain generally, must point new for a long time, if know cold of experiencing perfectly well, stutter cold thing and patient, when first, when medicine that is loose with temperature or temperature profit; If disease is slightly of a specified duration, Cheng Yu, Yu Ze steaming of a specified duration, heat must be lit a fire for a long time ..." having a stomachache also to have belongs to saying of heat, freely bright to Dan Xi.Stomachache and pained obscuring cause the attention of Ming Dynasty, as write in Ming Dynasty's " pained gastric abscess of the Standards of Diagnosis and Treatment ": " or asking the pained i.e. gastric abscess of Dan Xi speech that right to say the heart and stomach each one dirty; its sick shape is different; under gastric abscess is in the heart; therefore to have and take care and the name of pain, gastric abscess and pained " " medical science main story, gastric abscess " further points out that forefathers are pained non-with stomachache: " ancient prescription nine types of precordial pain; ... its reason in detail, all at gastral cavilty in fact at the heart not also." thus comparatively clear and definite differentiation has been carried out to two diseases.The cause of disease of stomachache is mainly diseases caused by exogenous pathogenic factor cold-evil, injury due to diet, and feelings will is unsuccessful, weakness of the spleen and stomach etc.1. cold-evil visitor cold syndrome of the stomach belongs to YIN pathogen, and its property stagnates spasm.Gastral cavilty top communicates with the external world with mouth, very cold, and cold-evil inhales people by mouth, or gastral cavity abdomen is suffered from cold, cold-evil's direct attack, and interior visitor in stomach, or takes medicine bitter cold too, or cold food damaging the spleen and stomach, and cause QI stagnated by cold, gastric qi is become estranged, and gastric qi blocks, stagnation of QI and blood may bring about pain.Said as " Plain Questions lifts a pain opinion section ": " between the intestines and stomach, under film is former, blood must not fall apart cold visitor, and little network is anxious to be drawn, therefore pain ".2. diet injures one's stomach stomach receiving food and drink digesting food, its gas with reduce to suitable, therefore the generation of stomachache and eating and drinking without temperance relation the closest.If eating and drinking without temperance, eating and drinking too much at one meal, impairing the spleen and stomach, retention of food and drink, causes gastric qi to be become estranged, mechanism of qi retardance in stomach, stagnation of QI and blood may bring about pain; Or the five tastes cross pole, pungent immoderate, or addiction to greasy and sweet foods savoury, or drink as slurry, then the impairment of the spleen hinders stomach, accumulates humidogene heat, retardance mechanism of qi, so that gastric qi retardance, and stagnation of QI and blood may bring about pain, all can cause stomachache.Therefore " Plain Questions, a numbness opinion section " is said: " eating twice as usual, the intestines and stomach is wound." " medical science main story, gastric abscess " say: " and just cause a disease by, how because of self-indulgent food, it is sad to like, and throw off restraint the hot wine of drink and decoct torch, cold and cool raw food of eating again, damage dusk towards wound, it is dark that day amasss the moon ... therefore gastralgia ".3. the lifting being received transporting, middle burnt mechanism of qi of hyperactive liver-QI attacking the stomach taste, depends on the catharsis of liver, and " Plain Questions, a precious life holotype opinion section " said " earth being dredged by wood " namely means this.So pathology just there will be wood prosperous gram of soil, or change of deficient earth being subjugated by wood.Be worried angry, feelings will is unsuccessful, the liver failing to maintain the normal flow of QI, stagnation of QI due to depression of the liver, and perverse and unreasonable manner violates stomach, so that gastric qi is become estranged, and gastric qi blocks, and can send out as stomachache.So " miscellaneous diseases source and course rhinoceros is lit up, gastropathy source and course " meaning: " stomachache, evil dry gastral cavilty disease also.Only irritability is multiplied for more so, sudden and violent with wood, and just gram also." stagnation of liver-QI with the passing of time, again can fire-transformation heat-dissipating, heat invading the stomach, causes syndrome of liver-stomach heat and pain.If the liver failing to maintain the normal flow of QI, functional activity of QI being not smooth, the blood stasis of blood is stagnant, can form blood stasis again, doublely sees that blood stasis is had a stomachache.Gallbladder and liver phase the exterior and the interior, all belong to wood.Gallbladder leading to falls, and the transporting and the stomach sum that contribute to spleen are fallen." Ling Shu Miraculous Pivot or Divine Axis, four seasonal epidemic pathogens " are said: " evil in gallbladder, inverse at stomach." if gallbladder disease loses in catharsis, gallbladder internal organs is logical to fall not normal, and courage is not fallen, the criminal's of driving in the wrong direction stomach, causes gastric qi and becomes estranged, and the retardance of liver and gall gastric qi machine, also can have a stomachache.4. weakness of the spleen and stomach spleen and stomach phase the exterior and the interior, with placed in the middle burnt, play altogether and is received the merit of transporting and transforming nutrients from foodstuff.Splenic qi tending to ascend, stomach-QI being apt to descend, being received of stomach is become thoroughly decomposed, and rely the transporting the lucid yang sending up of spleen, so gastropathy is often involved in spleen, the splenopathy is often involved in stomach.If ferritic is not enough, or overstrain, or injury due to diet, or excessively take cold and cool medicine, or prolonged illness taste are impaired, all can cause weakness of the spleen and stomach, deficiency-cold in middle-JIAO, cause stomach to lose replenishing vital QI with drugs of warm nature, have a stomachache.If consumption of YIN caused by febrile disease, or gastric heat fire stagnation, stomach-Yin of burning, or take fragrant dry crystalline substance of regulating the flow of vital energy for a long time, consume the moon that injures one's stomach, stomach mistake is moistened foster, also can cause stomachache.The kidney being the origin of congenital constitution, root of YIN and YANG, the sun of taste, entirely relies the warm of kidney yang; The moon of taste, the full nourishing relying kidney yin.If insufficiency of kidney-YANG, the not warm soil of fire, can cause deficiency of spleen-YANG, form deficiency of spleen-YANG and kidneyYANG, stomach loses the stomachache of replenishing vital QI with drugs of warm nature; If deficiency of kidney-YIN, kidney water can not go up Ji stomach-Yin, can cause deficiency of stomach-YIN, forms stomach deficiency of the kidney yin.Stomach loses and moistens foster stomachache.In addition, if the stagnation of QI with the passing of time, the blood stasis of blood is stagnant, or pain people network of a specified duration, and stomach network is obstructed, or after gastrorrhagia, blood circulating out of vessels does not eliminate, so that stops in blood stasis, and the retardance of stomach network is obstructed, and blood stasis all can be caused to have a stomachache." Linzheng Zhinan Yi gastric abscess " has the discussion about this pathogenesis already: " stomachache is sent out for a long time and repeatly, and solidifying expectorant must be had to gather the stasis of blood.If " spleen YANG deficiency, lose in strong fortune, endogenous dampness, the poly-expectorant that wets into becomes drink, accumulation gastral cavilty, can cause again phlegm retention stomachache.The primary disease cause of disease, just then many unsuccessful by exopathogen, diet, feelings will caused by, how single the cause of disease is, and pathogenesis is also simple, and the syndromes such as common cold-evil visitor stomach, retention of food and drink, hyperactive liver-QI attacking the stomach, syndrome of liver-stomach heat, damp-heat in the spleen and stomach, show as excess syndrome; Of a specified duration then common Sthenia is transforming into asthenia, as with the passing of time cold-evil damages spleen sun, with the passing of time pathogenic heat consumes the moon that injures one's stomach, and the syndromes such as common Deficiency and coldness of spleen and stomach, deficiency of stomach-Yin, then belong to deficiency syndrome.Void is caused because of real, or excess caused by deficiency, all can form deficiency and excess and witness, as gastric heat has the deficiency of YIN concurrently, YANG deficiency of the spleen and stomach is double sees endogenous cold, and hold concurrently the folder stasis of blood, food, the stagnation of QI, phlegm retention etc.The sick position of primary disease is at stomach, in close relations with liver spleen, also relevant with gallbladder kidney.Basic pathogenesis is gastric qi retardance, and stomach network stasis blocking, stomach is become homeless foster, stagnation of QI and blood may bring about pain.The position of stomachache, at epigastrium gastral cavilty place, is commonly called as precordial region.The character of its pain shows as distending pain, dull pain, twinge, causalgia, vexed pain, angor etc., often different because of the difference of etiology and pathogenesis, wherein especially common with distending pain, dull pain, twinge.Can tenderness be had, by its pain or increase or subtract, but without rebound tenderness.Its pain have in persistence person, also sometimes as time the person of stopping.Its pain Chang Yinhan warms up inappropriate, intemperance of taking food, inducements such as feelings will is not relaxed, tired and show effect or increase the weight of.This disease often with inappetence, nausea and vomiting, the symptoms such as acid regurgitation and epigastric upset.Upper abdomen gastral cavilty portion's pain and tenderness during this onste; Normal with inappetence, fullness and oppression in the stomach distension, nausea and vomiting, the symptom that the gastric qis such as acid regurgitation and epigastric upset are become estranged; Morbidity is normal by eating and drinking without temperance, and feelings will is unsuccessful, tired, and the inducement such as to catch cold causes; The inspections such as the barivm meal fluoroscopy (screem) of upper digestive tract x-ray, fibergastroscope and histopathology, look into pathological changes such as seeing Gastroduodenal mucosal lesions inflammation, ulcer, contribute to diagnosis.
Chronic pulmonary atrophic gastritis is one of common disease of digestive system, and in recent years along with the continuous quickening of rhythm of life and the irregular of diet, sickness rate rises gradually.This course of disease is long, is decades, rare spontaneous removing after infection helicobacter pylori, therefore the normal long-term sustainable existence of chronic gastritis, the chronic non-atrophic gastritis of small part can develop into chronic many stoves atrophic gastritis, western medicine instant effect, but easily recur, therapeutic effect is not good; Or be improved, see Relapse rate again, so that make a futile effort.Western medicine routine treatment is mainly with three or tetrad medication (eradicate helicobacter pylori, antibiotic, antacid, gastric mucosa protective agent, short digestive tract power reinforcing medicine etc.), but side effect is large, and patient compliance is poor, and expensive, and patient can not bear.Therefore herbal treatment is subject to the attention of more and more patient, chronic non-atrophic gastritis its show the diseases such as the similar traditional Chinese medical science " stomachache ", but the clinical one that lacks effectively can improve symptom, and can reduce the Chinese medicine preparation of relapse rate.
Summary of the invention
Technical problem to be solved by this invention is, provides that a kind of formula is simple, processing technology is easy, and toxic and side effects little and convenient drug administration, medicament are easy to manufacture, new drug with low cost.The present invention is Chinese medicine preparation, can reach yin nourishing stomach reinforcing, nourish blood, regulating the flow of Qi and the middle Jiao, relieving spasm to stop pain, increases the protective capability of gastric mucosa, increases the object of immunologic function of gastrointestinal peristalsis, loosening bowel to relieve constipation and raising body.The present invention also adopts the Chinese crude drug of different properties, has carried out scientific compatibility, can reach desirable therapeutic effect, and safety, and toxic and side effects is little, preparation is simple, focus of going directly, healing time is short, more after not easily recurrence etc.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of chronic non-atrophic gastritis, in described Chinese medicine preparation, the mass fraction of various crude drug is: Radix Glehniae 10 ~ 30 parts, Radix Ophiopogonis 15 ~ 30 parts, Radix Angelicae Sinensis 10 ~ 30 parts, 10 ~ 30 parts, the Radix Rehmanniae, Fructus Lycii 10 ~ 25 parts, Fructus Toosendan 15 ~ 30 parts, the Radix Paeoniae Alba 10 ~ 30 parts, Radix Glycyrrhizae Preparata 15 ~ 30 parts, Margarita powder 10 ~ 25 parts, Concha Ostreae 10 ~ 30 parts, Endoconcha Sepiae 10 ~ 25 parts, Cortex Magnoliae Officinalis 10 ~ 25 parts, Flos Rosae Rugosae 10 ~ 25 parts, Fructus Citri Sarcodactylis 10 ~ 30 parts, Fructus Cannabis 10 ~ 30 parts, Semen Trichosanthis 10 ~ 30 parts, Herba Dendrobii 10 ~ 25 parts, the Rhizoma Anemarrhenae 10 ~ 30 parts, Rhizoma Coptidis 10 ~ 30 parts, Rhodobryum roseum Limpr. 10 ~ 35 parts, Limax 10 ~ 30 parts, Herba Melastomatis dodecandri 10 ~ 25 parts.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of chronic non-atrophic gastritis, in described Chinese medicine preparation, the mass fraction of each crude drug can also be: described Radix Glehniae 15 ~ 25 parts, Radix Ophiopogonis 16 ~ 25 parts, Radix Angelicae Sinensis 15 ~ 25 parts, 15 ~ 25 parts, the Radix Rehmanniae, Fructus Lycii 15 ~ 20 parts, Fructus Toosendan 15 ~ 25 parts, the Radix Paeoniae Alba 15 ~ 25 parts, Radix Glycyrrhizae Preparata 15 ~ 25 parts, Margarita powder 15 ~ 20 parts, Concha Ostreae 15 ~ 25 parts, Endoconcha Sepiae 15 ~ 25 parts, Cortex Magnoliae Officinalis 15 ~ 25 parts, Flos Rosae Rugosae 15 ~ 25 parts, Fructus Citri Sarcodactylis 15 ~ 25 parts, Fructus Cannabis 15 ~ 25 parts, Semen Trichosanthis 15 ~ 25 parts, Herba Dendrobii 15 ~ 25 parts, the Rhizoma Anemarrhenae 15 ~ 25 parts, Rhizoma Coptidis 15 ~ 25 parts, Rhodobryum roseum Limpr. 15 ~ 30 parts, Limax 15 ~ 25 parts, Herba Melastomatis dodecandri 15 ~ 20 parts.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of chronic non-atrophic gastritis, in described Chinese medicine preparation, the mass fraction of each crude drug can be again: described Radix Glehniae 18 ~ 20 parts, Radix Ophiopogonis 18 ~ 25 parts, Radix Angelicae Sinensis 16 ~ 20 parts, 18 ~ 20 parts, the Radix Rehmanniae, Fructus Lycii 16 ~ 18 parts, Fructus Toosendan 18 ~ 20 parts, the Radix Paeoniae Alba 16 ~ 20 parts, Radix Glycyrrhizae Preparata 18 ~ 20 parts, Margarita powder 16 ~ 18 parts, Concha Ostreae 16 ~ 18 parts, Endoconcha Sepiae 16 ~ 20 parts, Cortex Magnoliae Officinalis 16 ~ 20 parts, Flos Rosae Rugosae 18 ~ 20 parts, Fructus Citri Sarcodactylis 16 ~ 20 parts, Fructus Cannabis 18 ~ 20 parts, Semen Trichosanthis 16 ~ 20 parts, Herba Dendrobii 18 ~ 20 parts, the Rhizoma Anemarrhenae 16 ~ 20 parts, Rhizoma Coptidis 16 ~ 20 parts, Rhodobryum roseum Limpr. 15 ~ 20 parts, Limax 18 ~ 20 parts, Herba Melastomatis dodecandri 18 ~ 20 parts.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of chronic non-atrophic gastritis, and the dosage form of described Chinese medicine preparation is honey refining pill, and described honey refining pill preparation method comprises the following steps:
A, get crude drug put into soak with ethanol after heat extract 1 time extractum 1;
Thickening filtration after b, medicinal residues extracting in water 2 times, obtains extractum 2;
C, by above-mentioned extractum 1 and extractum 2 mix homogeneously, and be condensed into pasty state, then add Mel and be twisted into pill.
Wherein, in described step a, getting the alcoholic degree that all crude drug add 5-8 times amount is 75-90% ethanol, soak 2-3.5 hour, then heating extraction 1-2.5 hour, leave standstill, get its supernatant, medicinal residues are for subsequent use, heating of supernatant concentrate 85 DEG C time relative density be 1.36 extractum 1.
In described step b, the medicinal residues of step a are soaked 1.5-2 hour, extract twice, each 1-1.5 hour, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 6000-14000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure obtains 85 DEG C, relative density is the extractum 2 of 1.36.
For solving the problems of the technologies described above, the present invention also provides a kind of Chinese medicine preparation for the treatment of chronic non-atrophic gastritis, and described Chinese medicine preparation is enema, and described enema preparation process is:
A, get crude drug and soak 1.5 hours, extract twice, each 1-1.5 hour, merge extractive liquid, filter, medicinal residues are for subsequent use, and during filtrate reduced in volume to 85 DEG C, relative density is the extractum shape of 1.36, obtains extractum 1;
B, the medicinal residues of step a are added 5-8 times amount alcoholic degree is the ethanol of 70%-90%, soak 1-1.5 hour, then twice is extracted, each 1-1.5 hour, merge extractive liquid, 80-140 order filters, 6000-10000 rev/min centrifugal after supernatant is the ultrafiltration post ultrafiltration of 6000-13000 through current-carrying molecular weight, when ultrafiltrate concentrating under reduced pressure obtains 85 DEG C, relative density is the extractum 2 of 1.32;
C, by extractum 1 and extractum 2 mix homogeneously, then thin up, obtains enema.
For solving the problems of the technologies described above, the present invention also provides a kind of using method for the treatment of chronic non-atrophic gastritis enema, get above-mentioned enema 150mL ~ 200mL at every turn, pour into 25mL ~ 50mL at every turn, inject with No. 12 oxygen catheters and 50mL syringe, insertion depth is for 14cm ~ 20cm, 2 ~ 3 times/day, each 15min-45min every 7 days is 1 course for the treatment of.
For solving the problems of the technologies described above, the present invention provides again a kind of preparation method for the treatment of the Chinese medicine preparation of chronic non-atrophic gastritis, described Chinese medicine preparation dosage form is suppository, and described suppository preparation process is: first distilled by all crude drug steam methods, obtain crystal; Then distillation test residue being put into 8 times amount alcoholic degrees is 75-90% ethanol, heating and refluxing extraction 2 times, each 0.5 ~ 2.5 hour, extracts active ingredient, 2 extracting solution is merged filtering and standing, gets its supernatant; Supernatant heating is concentrated, dries to obtain medicated powder, again the crystal of distillation extraction and the medicated powder obtained are mixed even, obtain mixture, mixture is added in the fat-soluble suppository substrate after heat fused, pour suppository moulds into after mix homogeneously, after cooling, namely taking-up obtains suppository.
For solving the problems of the technologies described above, the present invention reoffers a kind of Chinese medicine preparation for the treatment of chronic non-atrophic gastritis, and the dosage form of described Chinese medicine preparation is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey refining pill, powder, sublimed preparation, solution, injection, enema, suppository, plaster, syrup, powder, pin powder or slow releasing capsule.
When above-mentioned Chinese medicine preparation uses as enema, decoct soup and take, every day 1 dose, decocting is taken at twice, and every 7 days is a course for the treatment of; When described Chinese medicine preparation refines pill as honey, suppository uses, 3 times on the one, every 7 days is a course for the treatment of.
Chinese medicine preparation of the present invention has effect of yin nourishing stomach reinforcing, relieving pain by regulating middle-JIAO, cures mainly stomach-Yin loss, the diseases such as foster are moistened in stomach mistake; There is yin nourishing stomach reinforcing, nourish blood, regulating the flow of Qi and the middle Jiao, relieving spasm to stop pain, increases the protective capability of gastric mucosa, increases gastrointestinal peristalsis, immunologic function, protection gastric mucosa and raising autoimmunity that body is led to, improves in intestine moistening; Processing technology of the present invention is easy, and toxic and side effects is little, convenient drug administration, medicament are easy to manufacture, with low cost and focus of going directly, and healing time is short, not easily recur after healing.
Detailed description of the invention
Tool Chinese medicine is thought, the cause of disease of stomachache is mainly diseases caused by exogenous pathogenic factor cold-evil, injury due to diet, and feelings will is unsuccessful, weakness of the spleen and stomach etc.The primary disease cause of disease, just then many unsuccessful by exopathogen, diet, feelings will caused by, how single the cause of disease is, and pathogenesis is also simple, and the syndromes such as common cold-evil visitor stomach, retention of food and drink, hyperactive liver-QI attacking the stomach, syndrome of liver-stomach heat, damp-heat in the spleen and stomach, show as excess syndrome; Of a specified duration then common Sthenia is transforming into asthenia, as with the passing of time cold-evil damages spleen sun, with the passing of time pathogenic heat consumes the moon that injures one's stomach, and the syndromes such as common Deficiency and coldness of spleen and stomach, deficiency of stomach-Yin, then belong to deficiency syndrome.Void is caused because of real, or excess caused by deficiency, all can form deficiency and excess and witness, as gastric heat has the deficiency of YIN concurrently, YANG deficiency of the spleen and stomach is double sees endogenous cold, and hold concurrently the folder stasis of blood, food, the stagnation of QI, phlegm retention etc.The sick position of primary disease is at stomach, in close relations with liver spleen, also relevant with gallbladder kidney.Basic pathogenesis is gastric qi retardance, and stomach network stasis blocking, stomach is become homeless foster, stagnation of QI and blood may bring about pain.
The position of stomachache, at epigastrium gastral cavilty place, is commonly called as precordial region.The character of its pain shows as distending pain, dull pain, twinge, causalgia, vexed pain, angor etc., often different because of the difference of etiology and pathogenesis, wherein especially common with distending pain, dull pain, twinge.Can tenderness be had, by its pain or increase or subtract, but without rebound tenderness.Its pain have in persistence person, also sometimes as time the person of stopping.Its pain Chang Yinhan warms up inappropriate, intemperance of taking food, inducements such as feelings will is not relaxed, tired and show effect or increase the weight of.This disease often with inappetence, nausea and vomiting, the symptoms such as acid regurgitation and epigastric upset.Cold syndrome is had a stomachache common stomachache with cool feeling, showing effect or increasing the weight of, obtaining hot then alleviation of pain because drinking cold catching cold, and meets cold then pain and increases, white with complexion mattress, mouth and thirsty, light red tongue, the tongue disease such as in vain; Heat syndrome is had a stomachache the scorching hot pain of common gastral cavilty, and pungent scorching food of taking food is easy to bring out or increase the weight of, and like cold aversion to heat, gastral cavilty obtains cool, relaxes, with thirsty, and constipation with dry stool, red tongue, the few Tianjin of yellow fur, the diseases such as rapid pulse.The deficiency syndrome stomachache person that is more common in weakness due to chronic disease, its stomachache indistinctly, pain gesture low and without fixed place, or touch not its institute, when in time, done only, pain and not swollen or swollen and time subtract, easy Provocative pain or cause pain and increase the weight of during hungry or overwork, rub by maybe then pain relief must be eaten, weak with lack of appetite, the diseases such as deficient pulse; The new sick body person of strengthening is more common in excess syndrome stomachache, and its stomachache is held concurrently swollen, performance distending pain, twinge, pain gesture sharply tenderness, localized pain, postprandial pain very, with constipation, the diseases such as forceful pulse.First pain is at gas, and pain is at blood for a long time.Stomachache and swollen, based on swollen, migratory pain, time pain time only, often by feelings will not Shu Yinqi, companion's feeling of oppression and fullness in the chest and epigastrium, happiness is sighed, and obtains belch or vows gas then alleviation of pain person, belonging to edema caused by disorder of QI more; Have a stomachache to prolong for a long time and do not heal, its pain, as stung as bored, continues not understand, localized pain, bitterly tenderness, the increasing of companion's postprandial pain, purplish tongue, and the purple dark tortuous person of Sublingual venation, belongs to blood system more.And the indistinct causalgia of gastral cavilty, the loss of appetite like famine, dryness of the mouth and throat, thirsty think of drink, becomes thin weak, constipation with dry stool, red tongue with a little fluid or light stripping no fur, thready and rapid pulse, and card belongs to stomach-Yin virtual loss.Control based on eliminating evil, righting, the method for available yin nourishing stomach reinforcing.Deficiency and excess the person of opinion, then the method for strengthening vital QI to eliminate pathogenic factors is held concurrently and uses it.
Therefore advocate that treatment is when thinking that treating with Activating Qi and regulating stomach to relieve pain is basic principle, side selects YIGUANJIAN to close Radix Paeoniae zhigancao decoction plus-minus.Be intended to dredge mechanism of qi, recover stomach internal organs and suitable logical property of falling, general rule not bitterly, thus reaches the object of pain relieving.Liver belonging to Yin in physique and Yang in function, property happiness bar reaches dislikes depression.Hepatic and renal YIN deficiency, the liver failing to be nourished, catharsis is not normal, the stagnation of QI and stagnant, and perverse and unreasonable manner violates stomach, then breast gastral cavity hypochondriac pain, and acid regurgitation tells hardship.Deficiency of YIN liquid consumes, body fluid cannot flow upwards, dry mouth and throat, red tongue with a little fluid.Depression of liver-QI, the liver pulse stasis, then becomes hernia abdominal mass for a long time and gathers.Controlling the cloudy blood of nourishing the liver and kidney to be main, and compatibility dredges the product reaching irritability.
At us in plan side, reuse Radix Rehmanniae nourishing YIN and benefiting blood, liver and kidney tonifying is monarch.Radix Glehniae, Radix Ophiopogonis, Radix Angelicae Sinensis, the nourishing blood to suppress the hyperactive liver of Fructus Lycii tonifying YIN, coordinate monarch drug tonifying liver body, nourishing YIN and contain sun for ministerial drug.Use a small amount of Fructus Toosendan, soothing the liverly to expel the heat-evil, regulating QI to relieve pain, recover irritability bar soothing the liver for assistant.Though be the product of bitter cold, with a large amount of sweet cold nourishing YIN and benefiting blood medicine compatibility, then without the fraud of bitter dry impairment of YIN.We's compatible experiments is: with the cloudy blood medicine of group's nourishing the liver and kidney, help Fructus Toosendan simply less and, with depressed liver-energy dispersing and QI regulating, make nourishing YIN and benefiting blood and do not hold back stagnant mechanism of qi, depressed liver-energy dispersing and QI regulating does not consume impairment of YIN blood again; Radix Paeoniae, Radix Glycyrrhizae Preparata and middle relieving spasm to stop pain.Gastral cavity abdomen causalgia, noisy acid regurgitation therefore with Margarita powder, Concha Ostreae, Endoconcha Sepiae with antacid; The regulating QI to relieve pain such as Cortex Magnoliae Officinalis, Flos Rosae Rugosae, Fructus Citri Sarcodactylis, alleviate the symptom that epigastric distending pain has the stagnation of QI concurrently; Be hard and dry to be difficult to resolve and add with Fructus Cannabis, Semen Trichosanthis with loosening bowel to relieve constipation; Deficiency of YIN gastric heat person adds with Herba Dendrobii, the Rhizoma Anemarrhenae, Rhizoma Coptidis yin nourishing clearing stomach.
Radix Glehniae in side, cold nature, sweet in the mouth, micro-hardship." herbal classic is met former " cloud: " sweet light, cold in nature, nontoxic "; " Bencao Congxin " records it: " sweetness and bitterness is lightly seasoned, is slightly cold ".Enter lung, spleen channel, " book on Chinese herbal medicine brief points " cloud: " start with, meridian of Foot-TAI YIN ".There is nourishing YIN and clearing away lung-heat, effect of reinforcing stomach reg fluid, can be used for calentura Tianjin wound, the card such as thirsty." decoction pieces is newly joined " records it: " support lung stomach-Yin, control phthisical cough expectorant blood ".Deficiency of stomach-Yin, pain is drunk in gastral cavity portion, noisy like hungry person, then can be equal to use with Radix Ophiopogonis, the Radix Paeoniae Alba, Radix Glycyrrhizae Preparata, with YIN nourishing and the production of body fluid promoting pain relieving; Deficiency of stomach-YIN is double sees the hepatic and renal YIN deficiency, depression of liver-QI, and disease sees that hypochondriac pain gastral cavity is swollen, and acid regurgitation tells hardship, dry mouth and throat, red tongue with a little fluid person, can with Radix Ophiopogonis, the Radix Rehmanniae, Fructus Lycii etc. and execute.Medication is avoided: the anti-Rhizoma et radix veratri (Radix Rhizoma Veratri) of Radix Glehniae, evil Radix Stephaniae Tetrandrae.
Radix Ophiopogonis, sweet, the micro-hardship of property, is slightly cold; GUIXIN, lung, stomach warp.Have YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire, can be used for sore throat pharyngalgia, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation etc.Clear the moon of supporting lung stomach goes heart use more, and YIN nourishing clears away heart-fire the use that connects with the heart more.These product are sweet cold clear and rich, and be apt to control deficiency of stomach-Yin, dry tongue is thirsty, indigestion and loss of appetite not hungry card such as grade.In addition, also availablely deficiency of YIN dryness of the intestine is controlled, constipation person.Modern study shows, can improve immunologic function Radix Ophiopogonis, various bacteria be had to inhibitory action, can strengthen pituitary adrenal system function, improve organism adaptation ability.Radix Ophiopogonis joins Radix Adenophorae (Radix Glehniae), and lung stomach is ruled together, and has the cool stomach of lung heat clearing, the good effectiveness of YIN nourishing and the production of body fluid promoting, for the few expectorant of the dry cough caused by lung-dryness syndrome due to deficiency of YIN or thermal burn lung yin, and the diseases such as dry laryngopharynx.Medication is noted: all Deficiency and coldness of spleen and stomach are had loose bowels, and stomach has phlegm retention turbid damp and sudden and violent sense cough due to wind and cold person all to avoid to take Radix Ophiopogonis.Radix Rehmanniae, Herba Plantaginis make for it; Dislike coltsfoot, a bitter a kind of edible gourd Radix Ophiopogonis, fear Radix Sophorae Flavescentis, blue or green capsule.
Radix Angelicae Sinensis is sweet in the mouth, pungent, bitter, warm in nature; Return liver, the heart, spleen channel.Belong to hematonic, emmenagogue, analgesic.Have and enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize effect of laxation, can be used for all cards of blood deficiency, asthenia cold abdominalgia, dryness of the intestine dyschezia etc.Modern study shows, Radix Angelicae Sinensis has conditioner body immunity function, enriches blood and invigorate blood circulation, antibacterial effect of Denging.
The Radix Rehmanniae, nature and flavor are sweet, cold; GUIXIN, kidney channel.There is clearing away heat and cooling blood, yin nourishing, the effect of promoting the production of body fluid.Can be used for yin asthenia generating intrinsic heat etc., the evaluation of Li Shizhen (1518-1593 A.D.) to Radix Rehmanniae is: " one hundred days of clothes are rosy cheeks, within 3 years, make light of one's life by commiting suicide not old "." Yaoxing Fu " cloud: " sweet in the mouth, hardship, cold in nature, nontoxic.Sink also, the moon also.It is with having four: the heat in blood of cool heart-fire, purgation of spleen excess soil damp and hot, and the nosebleed only in nose is hot, the dysphoria with smothery sensation except five hearts ".In all epidemic febrile disease later stages, waste heat is most, body fluid being damaged, dry mouth and tougue, night fever abating at dawn person; The not criminal's of order copper ferrum device; The Radix Rehmanniae avoids Radix Raphani, Bulbus Allii Fistulosi, fragrant-flowered garlic oneself, Bulbus Allii Macrostemonis.
Fructus Lycii, people are daily eats the fruit " Fructus Lycii " mostly being Lycium barbarum L. with medicinal Fructus Lycii, and lycium barbarum is the kind of unique loading " version Chinese Pharmacopoeia in 2010 ".Lycium barbarum is also maximum at Chinese cultivated area simultaneously.Fructus Lycii, this title is first appeared in " Book of Songs " before China's two thousand years.Fructus Lycii nature and flavor are sweet, flat.There is the function of nourishing the liver, nourishing kidney, lung moistening.Influence is had to immunologic function.Fructus Lycii is classified as " medicine-food two-purpose " kind by Ministry of Public Health, and Fructus Lycii can be processed into various food, beverage, health promoting wine, health product etc.Also often Fructus Lycii is added at Baoshang or when cooking congee.
Fructus Toosendan, nature and flavor are cold in nature, bitter in the mouth, slightly poisonous; " herbal classic " cloud its: " bitter, cold "; " not Lu ": " slightly poisonous "; Return liver, small intestinal, urinary bladder channel.There is soothing liver-QI, the functions such as promoting the circulation of QI to relieve pain., can to coerce in breast, abdominal distention, colic, abdominal pain due to worm stagnation etc." pearl sac " is recorded: " suffer from abdominal pain in Your Majesty bottom, heart sudden pain ".Compatibility compatibility and incompatibility of drugs: 1. " detailed outline ": " Fructus Foeniculi makes for it "; 2. Deficiency and coldness of spleen and stomach person avoids clothes.
The Radix Paeoniae Alba, nature and flavor picric acid, is slightly cold; Enter liver, spleen channel, " herbal classic " cloud: " bitter in the mouth, flat "; " Bencao Jingshu " cloud: " the lunar guiding drug of brothers enters liver, spleen blood system ".It has nourishing blood to suppress the hyperactive liver, pain relieving in slow, and yin fluid astringing receives the effects such as antiperspirant, be applicable to fever due to yin deficiency, the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, etc. disease.Its paeoniflorin contained has antibacterial, antipyretic, antiinflammatory, anticoagulant, calmness, analgesia, spasmolytic, antiulcer effect.Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc." herbal classic " records it: " main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, control cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating "; " medicine origin " also cloud: " peace spleen channel, controls stomachache, receives gastric qi, antidiarrheal profit, and blood, fixing striae, eliminating pathogen in the liver, tonifying the spleen and stomach ".The Radix Paeoniae Alba is cold in nature, inedibility during the deficient cold type stomachache person of having loose bowels and children's suffer from measles.
Radix Glycyrrhizae Preparata, sweet in the mouth, property is put down, nontoxic.Can treating disorders in five ZANG-organs six internal organs cold and heat pathogen, hard muscles and bones, longue meat, times strength, removing toxic substances, clothes are made light of one's life by commiting suicide and are prolonged life for a long time.Raw by pathogenic fire purging heat, ripe use is fallen apart exterior cold, goes pharyngalgia, except pathogenic heat, and slow healthy energy, yin nourishing blood, tonifying the spleen and stomach, lung moistening.Radix Glycyrrhizae Preparata, is longer than warming middle-JIAO, and with sweet temperature QI invigorating, relieving spasm to stop pain power is strong.Weak for insufficiency of the spleen stomach, cardiopalmus irregularly intermittent and regularly intermittent pulse etc.Modern study shows, Radix Glycyrrhizae has the effect of similar adrenocortical hormone sample.Inhibitory action is had to the gastroxia that histamine causes; And have antiacid and alleviate the effect of gastrointestinal smooth muscle spasm.In addition, Radix Glycyrrhizae also has antiinflammatory, and anti-allergic effects medication is noted: Radix Glycyrrhizae is suitable for gastric ulcer person, duodenal ulcer person, neurastheniac, bronchial asthma person, thrombophlebitis patient; Wet Sheng distension, edema person should not use.Can not with Cyprinus carpio with eating, with eating, meeting is poisoning; The anti-Radix Euphorbiae Pekinensis, Flos Genkwa, Radix Kansui, Sargassum; Take the Radix Glycyrrhizae of larger dose for a long time, can edema etc. be caused.
Margarita powder, mainly with enzymolysis or acid hydrolysis method manufacture, is characterized in water-soluble, and the people being applicable to achlorhydria uses.Margarita is medicinal in China's history of existing more than 2000 years.Medical book " Mingyi Bielu " during three states, " book on Chinese herbal medicine is through the collection " in beam generation, " Haiyao Bencao, Oversea Materia Medica " of the Tang Dynasty, 19 kinds of medical ancient books such as " Kaibao Bencao ", the Compendium of Material Medica of the Ming Dynasty, the Leigon's Nature of Drugs in Songs of the Qing Dynasty of Song dynasty, all have clear and definite record to the curative effect of Margarita.Modern study also shows that Margarita powder main component is the calcium carbonate of protein (can obtain 18 seed amino acids after hydrolysis, wherein 7 kinds is essential amino acid), aragonite structure, 20 various trace elements and vitamin B.It all has the effect of uniqueness in body immunity, slow down aging, freckle removing and whitening, supplement calcium etc. improving.
Concha Ostreae, nature and flavor are salty, are slightly cold; Return liver, gallbladder, kidney channel.Belong to yin-nourishing drug.Modern study shows that in Concha Ostreae, contained abundant taurine has obvious hepatic cholagogic effect, and this is also the good medicine of control pregnancy period functional condition in intrahepatic cholestasis; Contained enriches trace element and glycogen, to promoting the growth promoter of fetus, rescues pregnant woman anemia and all beneficial to the antisecosis of anemia of pregnant woman; Concha Ostreae is again the best food of replenishing the calcium, and it is phosphorous very abundant, because calcium is needed the help of phosphorus, so be conducive to the absorption of calcium during body absorption; Concha Ostreae is also containing vitamin B12, and this is that general food lacked, and the brill element in vitamin B12 is the indispensable material of prevention pernicious anemia, and thus Concha Ostreae has again the effect enlivening hemopoietic function; Have multiple excellent aminoacid in protein contained in Concha Ostreae, these aminoacid have Detoxication, can remove the noxious substance in body.Also have the effect of tonifying YIN YANG hyperactivity suppressing, can be used for the agitation that hyperactivity of YANG due to deficiency of YIN causes, insomnia, dizziness headache, one's ears rang and spots danced before one's eyes, hectic fever night sweat; Stomachache pantothenic acid etc.Compendium of Material Medica is recorded: Carnis ostreae " polyphagia it, can fine work skin, kidney invigorating and YANG supporting, and can control void, separates erysipelas ".The traditional Chinese medical science thinks that the meat of Concha Ostreae has good food therapy value, be simply extraordinary YIN nourishing, enrich blood, and the food of libido can also be excited, be specially adapted to the people of asthenia, deficient sufferer and those deficiency of YIN, anemia, insufficiency of vital energy and blood.
Endoconcha Sepiae, salty in the mouth, puckery, slightly warm in nature.Return liver, kidney channel." herbal classic " cloud: " salty in the mouth, tepor "; " detailed outline " cloud: " cloudy blood system of fainting ".There is effect of relieving gastric hyperacidity to alleviate stomachache.Calcium carbonate contained by it, can do antacid agent." modern Practical Chinese medicinal " is recorded: " being antacid, effective to hyperchlorhydria, gastric ulcer ".But the deficiency of YIN frequent fever person should not take more; Clothes of a specified duration easily cause constipation, suitably can join the same Collective Notes to the Canon of Materia medica of aperitive: " dislike hold back in vain, Pseudobulbus Bletillae (Rhizoma Bletillae) ".
Cortex Magnoliae Officinalis, bitter in the mouth, pungent, warm in nature; Return spleen channel, stomach warp, large intestine channel.Belong to removing dampness by means of aromatics Chinese medicine.There is circulation of qi promoting removing food stagnancy, dampness except effect that is full, lowering the adverse QI to relieve asthma, cure mainly stagnation of QI due to dyspepsia, abdominal distention constipation, retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea, expectorant stops up QI rising in reverse order, fullness in the chest is breathed with cough.Come from Shennong's Herbal.Modern study shows that it has antibacterial action: the second of Cortex Magnoliae Officinalis and methanolic extract have strong antibacterial action to cariogenic bacteria Streptococcus mutans, and its Antibacterial Constituents is defined as Magnolol and Honokiol.Both are 6.3 μ g/ml to the minimum inhibitory concentration (MIC) of Streptococcus mutans, and its antibacterial action (to Streptococcus mutans) is stronger than berberine.The first deduction of Cortex Magnoliae Officinalis divides magnocurarine and Cortex Magnoliae Officinalis volatile oil saturated aqueous solution to have certain bacteriostasis to staphylococcus aureus, sarcina and bacillus subtilis.Cortex Magnoliae Officinalis also has antibacterial to Diplococcus pneumoniae and dysentery bacterium.Its magnolol contained has and prevents the handicapped effect of irritability stomach.Cortex Magnoliae Officinalis and volatile oil bitter in the mouth thereof can stimulate the sense of taste, reflexively cause saliva, gastric secretion, gastrointestinal peristalsis to accelerate, and have stomach invigorating digestion-aid effect.It should not eat together with beans, because containing tannin in Cortex Magnoliae Officinalis, rich in proteins in bean food, the two chemically reactive of meeting and get along well mutually, forms non-digestible tannin albumen.In addition, all more complicated of organic principle contained by the two, also may can produce other untoward reaction with food, cause beans to be difficult to digestion, form gas and fill intestinal, cause abdominal distention; Anemia of pregnant woman is cautious use of.Collective Notes to the Canon of Materia medica cloud: " Rhizoma Zingiberis makes for it.Dislike Rhizoma Alismatis, Mirabilitum crystallina, Sal Nitri "; " property of medicine opinion " cloud: " avoid bean, the person of food takes offence "; " product converge with essence will " also cloud: " gestation can not take ".
Flos Rosae Rugosae, sweet, the micro-hardship of nature and flavor, temperature; Return liver, spleen channel.There are promoting QI circulation for relieving depression, and blood, effect of pain relieving, can be used for stomachache due to hyperactive liver-QI attacking the stomach, lack of appetite vomiting and nausea, menoxenia etc.Flos Rosae Rugosae has strong sweet fragrance, is the main additive of some food, cosmetics, suitable pachylosis, Anemic patients, the person of having a delicate constitution; " food book on Chinese herbal medicine " calls it, and " main sharp lung spleen, the liver benefiting gallbladder, the fragrance of food is sweet and refreshing, makes us refreshing refreshing." its regulating the flow of vital energy of having and blood, eliminating toxin and beautifying the skin and blood scattered silt, having one's ideas straightened out silt, to be soothing the liverly amusing, to promote bile secretion, to help digest, effect of regulation mechanism is mainly applicable to that hypochondriac pain gastral cavity caused by incoordination between the liver and stomach is vexed, epigastric distending pain and menoxenia or premenstrual distending pain of the breast person.Flos Rosae Rugosae is dried in the shade, rush soup takes for tea, treats for stomachache, stomachache due to hyperactive liver-QI attacking the stomach; But the deficiency of YIN has fiery person not take.
Fructus Citri Sarcodactylis, nature and flavor are pungent, bitter, sour, temperature; Return liver, spleen, lung meridian.There is liver-smoothing, qi-regulating, and effect of stomach and alleviating pain, can be used for stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted.Li Shizhen (1518-1593 A.D.) is recorded in Compendium of Material Medica: " Fructus Citri Sarcodactylis abnormal smells from the patient is pungent, and temperature is nontoxic; Cure mainly the therapeutic method to keep the adverse QI flowing downwards, except mind expectorant water; Boil beverage, control abundant expectoration and cough and gargle; Boil soup, control pain due to disorder of QI under the heart ".Pharmacological research shows, Fructus Citri Sarcodactylis, mainly containing Coumarinses such as citropten .s, still containing flavonoid glycoside, Hesperidin, organic acid, volatilization wet goods, has obvious inhibitory action to intestinal smooth, has obvious spasmolysis etc. to the duodenum spasm that acetylcholine causes.. " the southern regions of the Yunnan Province book on Chinese herbal medicine " is recorded: " cold syndrome of the stomach that disappears expectorant, controls gastric qi pain for tonifying liver warming the stomach, anti-nausea, the only cold pain in face, and middle circulation of qi promoting "; " occupying diet spectrum with breath " cloud: " stomach eliminating phlegm of waking up, ward off evil, neutralize the effect of alcoholic drinks, help digestion pain relieving ".The deficiency of YIN has fire, without the careful clothes of stagnation of QI symptom, and " herbal classic is met former " cloud: " the dysentery deficiency of vital energy of a specified duration, its institute non-is suitable ".
Fructus Cannabis, nature and flavor are sweet, flat; Return spleen, stomach, large intestine channel.There is the effect of moisturizing laxation relieving constipation, can be used for blood deficiency and depleted fluid, dryness of the intestine constipation." medicineization justice " cloud: " body profit can be gone dry, and patent large intestine is depressed just to be closed for Fructus Cannabis, energy intestine moistening.All old blood is uninteresting, and puerperal, QI and blood had some setbacks, and vigour is multiple after being ill, or reports weak can not operation and all control.It is obstructed that large intestine closes knot, should not push away and swing, also not allow to close for a long time, moisten its lung qi, grow its large intestine with this same Radix Asteris, Semen Armeniacae Amarum, then just diarrhea " " book on Chinese herbal medicine analyze mentally record " cloud: " Zhong Jing syndrome of pill MAREN(Fructus cannabis), be spleen be subject to stomach strong tire out and about and not relax.How so spleen is loose be skillful in lung, the order of falling of lung is also lost, and lung and taste are all tired and just under energy.The sweet level and smooth profit of Fructus Cannabis, firm but gentle, spleen can be entered and grow Qi Yin Tianjin, change its dryness.But spleen is as about, heavily fortified point knot is wherein known, Fructus Cannabis can expansion can not break it, Radix Paeoniae is the gas medicine in spleen man removing blood stasis, that conjunction is executed and spleen its maybe not about.Husband's spleen-constipation is strong due to stomach, control spleen here not doublely control stomach, stomach not only falls, and provides in lung, and here lung also must be ignored, therefore helps again and attack stomach with Radix Et Rhizoma Rhei, trifoliate orange, Piao, and Semen Armeniacae Amarum presses down lung, and disease is given birth to by stomach, and with spleen-constipation entitling person, as the non-typical YANG MING syndrome of Taiyang Yangming also.Double sun event frequent micturition, frequent micturition event difficulty in defecation, method for the treatment of is to play the cloudy dryness-transformation gas of spleen.Dryness is removed and the sun is recovered without treatment, therefore Fructus Cannabis is key medicine ".
Semen Trichosanthis, sweet, the micro-hardship of nature and flavor, cold; Return lung, stomach, large intestine channel.There is relieving stuffiness of the chest by dispersing aggregation of pathogens, the effects such as loosening bowel to relieve constipation, can be used for acute appendicitis, dryness of the intestine constipation etc.Modern study shows that it can improve body's immunity, and has effect of weight reducing beauty treatment.But it should not with Aconitum medical material with using.
Herba Dendrobii, nature and flavor are slightly cold, sweet; Return stomach, kidney channel.It has reinforcing stomach reg fluid, and effect of nourishing YIN and clearing away heat, can be used for consumption of body fluid by heat, low grade fever excessive thirst, the few tongue of red tongue; Deficiency of stomach-Yin, thirsty and dry pharynx, vomiting is eaten less, vague epigastralgia, the few tongue of tongue light; Deficiency of kidney yin, the diseases such as blurring of vision.Stomach has deficiency-heat, deficiency of body fluid, very thirsty in mouth, and diet is not fragrant: alone this product is appropriate, decocting, for tea-drinking use, has nourishing the stomach of promoting the production of body fluid, and the merit helped digest but heat it should be noted that the early stage non-the wounded of the moon of disease, the non-dryness-transformation person of damp-warm diseases, Deficiency and coldness of spleen and stomach person (referring to the very few person of gastric acid secretion), all prohibits clothes.
The Rhizoma Anemarrhenae, gunpowder under genus heat clearing away.Its nature and flavor are bitter, sweet, cold; Return lung, stomach, kidney channel.Have clearing away heat-fire, the function of moisturizing of promoting the production of body fluid, can be used for osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation etc.Modern study shows that the Rhizoma Anemarrhenae has resisting pathogenic microbes, antipyretic effect, and has impact to 17-hydroxy-11-dehydrocorticosterone effect.During for dryness of the intestine constipation, normal and Radix Polygoni Multiflori, Radix Angelicae Sinensis, the same use of Fructus Cannabis, have again the effect of loosening bowel to relieve constipation.
Rhizoma Coptidis, nature and flavor are bitter, cold, nontoxic; Return spleen, stomach, liver, gallbladder, large intestine channel.There is heat clearing and damp drying, effect of eliminating fire and detoxication, can be used for damp and hot feeling of fullness, vomiting acid regurgitation, dysentery; Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting, ties mutually for cold and heat, damp and hot middle resistance, and feeling of fullness is vomitted; Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting, for incoordination between the liver and stomach, vomiting acid regurgitation.Modern study shows that it has antibacterial action, can anti-Staphylococcus aureus, Hemolytic streptococcus, streptococcus pneumoniae, meningococcus, dysentery bacterium, anthrax bacillus etc." Kaibao Bencao " cloud: " bitter in the mouth, is slightly cold, nontoxic.The five internal organs are cold and hot, let out Bleach, pus and blood, only quench one's thirst for a long time, frightened, except water conservancy bone, adjust stomach, thick intestinal, beneficial gallbladder, treat aphtha ".In addition, it also has the pharmacologically actives such as protection gastric mucosa, has effect of heat clearing and damp drying, eliminating fire and detoxication.
Rhodobryum roseum Limpr., pungent, bitter, flat, tranquilizing by nourishing the heart, liver heat removing and eyesight improving.For severe palpitation, neurasthenia; Conjunctival congestion and swelling pain is controlled in external." light micro-hardship, flat." calmness of calming the nerves.Control that heart disease is nervous, cardiopalmus, neurasthenia." choosing of Yunnan Chinese herbal medicine ": " calm, tonifying YANG." " choosing of Simao, Yunnan Chinese herbal medicine ": " calmness of calming the nerves.Control nervous, cardiopalmus.Heart disease."
Limax, salty in the mouth, cold." dispelling wind, calm, Gu de-, removing toxic substances.Cure mainly herpes simplex toxic swelling, bronchus is panted, hemorrhoid toxic swelling, proctoptosis etc." herbal classic ": " salty in the mouth, cold." " not Lu ": " be nontoxic." " book on Chinese herbal medicine is new again ": " enters liver, spleen, lung three warp." function cures mainly, clearing away heat and expelling wind, subduing swelling and detoxicating, and broken expectorant stimulates the menstrual flow.Control middle windlean out-of-the-way, the contracture of muscle arteries and veins, infantile convulsion, pants, sore throat, pharyngeal swelling, carbuncle, erysipelas, amenorrhea, lump in the abdomen, centipete bite." herbal classic ": " main harmful wind is askew out-of-the-way, be lost muscle and proctoptosis, infantile convulsion contracture." amplification on Canon of Materia Medica: " controls Scolopendra, scorpion venom." " detailed outline ": " controls Zhong Du inflammation heat, and herpes simplex swells and ache." " book on Chinese herbal medicine converges and says ": " is apt to control all wind heat fire dry is eyes afflicted with calaract, and all wind heat fire-phlegm are disease." " book on Chinese herbal medicine is high former ": " main arresting convulsion heat clearing away, detoxify defeated (relaxing) muscle.Control laryngopharynx swelling and pain, acute pharyngitis due to wind-heat, include in larynx, order is swallowed." " must book on Chinese herbal medicine be joined ": " expectorant core." " Quanzhou book on Chinese herbal medicine ": " stimulate the menstrual flow removing blood stasis with potent drugs, removing toxic substances and promoting subsidence of swelling, diuresis.Cure mainly menstruation apolipsis ， mass in the abdomen stomachache, traumatic blood stasis is had a pain, carbuncle erysipelas." " Jilin Chinese herbal medicine ": " dispelling wind, relieving convulsion, Gu de-.Control herpes simplex to swell and ache, bronchitis, proctoptosis."
Herba Melastomatis dodecandri, property is put down, the micro-sweet acid of taste." containing phenols, tannin, saccharide, amino." east, Fujian book on Chinese herbal medicine ": " enter liver, kidney, spleen, lung four warp." invigorate blood circulation, hemostasis, dampness removing, removing toxic substances, controls dysmenorrhea, puerperal abdonimal pain, metrorrhagia, leucorrhea, dysentery, scrofula, toothache." east, Fujian book on Chinese herbal medicine ": " can stop blooding and invigorate blood circulation, the hernia that disappears of detoxifying.Control dysmenorrhea, metrorrhagia and leukorrhagia, dysentery, hemorrhoid complicated by anal fistula, rubella, hernia." relieving dysentery with astringents, relaxing muscles and tendons and activating QI and blood in the collateral, enriching blood to prevent miscarriage.Control enteritis, bacillary dysentery; Lumbago and skelalgia, rheumatic ostalgia; Pregnant woman anemia, frequent fetal movement, menorrhagia."
Embodiment 1 honey refining pill
The manufacturing process of oral medicine honey refining pill of the present invention is: get Radix Glehniae 1900g, Radix Ophiopogonis 2200g, Radix Angelicae Sinensis 1800g, Radix Rehmanniae 1900g, Fructus Lycii 1600g, Fructus Toosendan 1900g, Radix Paeoniae Alba 1800g, Radix Glycyrrhizae Preparata 2400g, Margarita powder 1600g, Concha Ostreae 2000g, Endoconcha Sepiae 1600g, Cortex Magnoliae Officinalis 1600g, Flos Rosae Rugosae 1800g, Fructus Citri Sarcodactylis 1800g, Fructus Cannabis 1900g, Semen Trichosanthis 2200g, Herba Dendrobii 1800g, Rhizoma Anemarrhenae 1800g, Rhizoma Coptidis 2200g, Rhodobryum roseum Limpr. 1800g, Limax 1600g, Herba Melastomatis dodecandri 1600g, getting the alcoholic degree that all crude drug add 7 times amount is 80% ethanol, soak 3 hours, then heating extraction 2 hours, leave standstill, get its supernatant, medicinal residues are for subsequent use, heating of supernatant concentrate 85 DEG C time relative density be 1.36 extractum 1,
The medicinal residues of step a are soaked 2 hours, extracts twice, each 1 hour, merge extractive liquid, 100 orders filter, then are the ultrafiltration post ultrafiltration of 9000 through the molecular weight that dams, and when ultrafiltrate concentrating under reduced pressure obtains 85 DEG C, relative density is the extractum 2 of 1.36;
Again by above-mentioned two kinds of extractum extractum 1 and extractum 2 mix homogeneously, and be condensed into pasty state, then add the honey refining pill that Mel is twisted into 0.8 gram every.
Embodiment 2 enema
The preparation process of external enema of the present invention is: get Radix Glehniae 1000g, Radix Ophiopogonis 1500g, Radix Angelicae Sinensis 1000g, Radix Rehmanniae 1000g, Fructus Lycii 1000g, Fructus Toosendan 1500g, Radix Paeoniae Alba 1000g, Radix Glycyrrhizae Preparata 1500g, Margarita powder 1000g, Concha Ostreae 1000g, Endoconcha Sepiae 1000g, Cortex Magnoliae Officinalis 1000g, Flos Rosae Rugosae 1000g, Fructus Citri Sarcodactylis 1000g, Fructus Cannabis 1000g, Semen Trichosanthis 1000g, Herba Dendrobii 1000, Rhizoma Anemarrhenae 1000g, Rhizoma Coptidis 1000g, Rhodobryum roseum Limpr. 1000g, Limax 1000g, Herba Melastomatis dodecandri 1000g, soak 1.5 hours, extract twice, each 1 hour, merge extractive liquid, filter, medicinal residues are for subsequent use, during filtrate reduced in volume to 85 DEG C, relative density is the extractum shape of 1.36, obtain extractum 1,
The medicinal residues of step a being added 7 times amount alcoholic degrees is the ethanol of 80%, soak 1 hour, then twice is extracted, each 1.5 hours, merge extractive liquid, 120 orders filter, 8000 revs/min centrifugal after supernatant through current-carrying molecular weight be 10000 the ultrafiltration of ultrafiltration post, when ultrafiltrate concentrating under reduced pressure obtains 85 DEG C, relative density is the extractum 2 of 1.32;
By extractum 1 and extractum 2 mix homogeneously, then thin up, obtain enema.
Embodiment 3 suppository
The preparation process of suppository of the present invention is: get Radix Glehniae 3000g, Radix Ophiopogonis 3500g, Radix Angelicae Sinensis 3000g, Radix Rehmanniae 3000g, Fructus Lycii 2500g, Fructus Toosendan 3000g, Radix Paeoniae Alba 3000g, Radix Glycyrrhizae Preparata 3000g, Margarita powder 2500g, Concha Ostreae 3000g, Endoconcha Sepiae 2500g, Cortex Magnoliae Officinalis 2500g, Flos Rosae Rugosae 2500g, Fructus Citri Sarcodactylis 3000g, Fructus Cannabis 3000g, Semen Trichosanthis 3000g, Herba Dendrobii 2500, Rhizoma Anemarrhenae 3000g, Rhizoma Coptidis 3000g, Rhodobryum roseum Limpr. 3500g, Limax 3000g, Herba Melastomatis dodecandri 2500g, first add 1200 ml waters by all crude drug, with steam method distillation, obtain crystal; Then distillation test residue being put into 8 times amount alcoholic degrees is 75-90% ethanol, then heating and refluxing extraction 2 times, each 0.5 ~ 2.5 hour, extract active ingredient, 2 extracting solution are merged filtering and standing, gets its supernatant, supernatant concentration is become medicated powder, again the crystal of distillation extraction and the medicated powder that obtains are mixed even mixture, after fat-soluble suppository substrate heat fused, add mixture, after mix homogeneously, pour suppository moulds into, after cooling, namely taking-up obtains suppository, every suppository about 3g.
Pharmacology pharmacodynamic is tested:
1, cumulative toxicity test report
Test method: select 30 healthy mices, female, each 15 of hero, with the enema of the embodiment of the present invention 2 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD50,0.50LD50, the LD50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.
2, acute toxicity test: with the suppository of the embodiment of the present invention 3 for object, gives white mouse large enteral dispensing, observes 7 for 150 times of clinical consumption per day.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse vagina and damaged skin, there are no irritative response and other untoward reaction.Toxicity test proves, the not toxic effect of this medicine and untoward reaction, clinical practice is safe and reliable
3, to the bacteriostasis of common bacterial strain
Solid process antibacterial action: line on blood ware or ordinary nutrient agar plate so that various test organisms is intensive, punch with 8mm card punch, every hole adds aseptic reagent and is about 0.3ml, cultivate 12 ~ 24 hours at 36.5 DEG C, observe the size of inhibition zone, for the honey of the embodiment of the present invention 1 refining pill, judge that its responsive result is as following table.
| Bacterial strain | Strain number | 100% pill | 200% pill | 300% pill |
| Staphylococcus aureus | M122 | --- | ++++ | ++++ |
| Staphylococcus albus | M121 | -- | +++++ | +++++ |
| Bacillus pyocyaneus | Ps207 | - | +++ | ++++ |
| Bacillus proteus | E402 | + | ++ | +++ |
| Escherichia coli | E100 | - | ++ | ++ |
| Bacillus subtilis | 63051 | ++ | ++++ | +++ |
| Diphtheria corynebacterium | C102 | + | +++ | ++++ |
| Diplococcus pneumoniae | M311 | - | ++++ | +++ |
| Bacillus typhi | E686 | ++ | +++ | ++++ |
| Paratyphoid bacillus A | 50073 | ++ | +++ | ++ |
| Bacillus paratyphosus B | 50094 | + | ++ | ++++ |
| Beta hemolysis streptococcus | M220 | ++ | ++++ | +++ |
Antibacterial circle diameter < 10mm., drug resistance-; Antibacterial circle diameter >=10 ~ 16mm, slight sensitive+; Antibacterial circle diameter >=15 ~ 20mm, medium sensitivity ++; Antibacterial circle diameter >=20 ~ 30mm, extremely sensitive +++; Antibacterial circle diameter >=29mm, special extremely sensitive ++++.
Above extracorporeal bacteria inhibitor test shows, the honey refining pill of the embodiment of the present invention 1 truly has obvious inhibitory action to common antibacterial.
4. hypersensitive test:
Get healthy albino guinea-pig 20, body weight 230-300g, male and female have concurrently, and reject both sides dorsal body setae before test, every side 2.5 × 2.5cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 0.5% concentration, excites and uses 0.2% concentration.The enema 0.2g getting the embodiment of the present invention 2 is applied to unhairing district, back, the next day 1 time, totally 3 times.In latter 14 days of last contact, at back, the same area smeared this product 0.2g, at once observes after removing medicine after 7h, and in 28,56,84h observes with or without anaphylaxis.Blank group and positive controls excite by same method and contact and observe.Result of the test: namely positive controls animal skin occurs localized erythema and slight edema in sensitization after 1.5 hours, within 28 hours, symptoms of allergic increases the weight of, and have scleroma to be formed, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.
Clinical data
1, data and method
1.1 physical data: during selecting in February ,-2013 in March, 2011, the chronic non-atrophic gastritis of my institute's diagnosis and treatment is totally 300 examples, wherein, man 138 example, female 162 example, less than 20 years old age person 120 example, 20-45 year person 150 example, more than 45 years old 30 is routine.In addition 300 routine patients are divided into two groups at random, treatment group 126 example, matched group 174 example.Two groups of patients comparing difference not statistically significant in age, sex, state of an illness weight, has comparability, and according to the weight out-patient treatment of the state of an illness.
The clinical manifestation of chronic gastritis lacks specificity, and the weight of symptom and mucosa infection degree not quite identical.Symptom is without specificity, about half patient has middle epigastric discomfort, dull pain, shortage rhythmicity, can increase the weight of after the meal, man have loss of appetite, heating installation, acid regurgitation, feel sick etc. indigestion symptom, companion bleeder can have melena or hemafecia, and patients with atrophic gastritis can have anemia, becomes thin, glossitis, diarrhoea etc.Health check-up can have upper abdomen tenderness, and small number of patients has anemia looks, also shows as distention and fullness in the abdomen, gastral cavilty portion pain, in the heart tired plug, and gas of vomitting is indigestion and loss of appetite, stomachache, and light red tongue is dark, acid regurgitation, the dyspepsias such as inappetence.
1.2 diagnostic criteria
(1) performance of superficial gastritis:
1. mucus increases and is attached to difficult drop-off on mucosa, and after washing out with water, the rubescent or erosion of visible mucomembranous surface is stripped off, and the mucus that needs to backflow with the mucus swallowed or duodenum is differentiated mutually, and mucus of generally backflowing contains bubble and mobile with wriggling.
2. stigma lamellar or wire rubescent, some places are congested, and some places are not congested, therefore in plaque-like, not clearly, tone is scarlet for rubescent boundary, and wire hyperemia is common in wrinkle wall bump pad.
3. red and white or piebaldism, for being dispersed in uniform small red dot, the mucosa between red point and stain shows slightly pale, has the skin of point image infant, and general mucosa is more smooth.
4. edema, mucus is by force reflective, slightly pale, swelling sense.
5. rotten to the corn person's surface mucous strips off, and often has white fur, can be divided into three types again: protrude type, as pimple shape top has umbilicus sample to cave in; Flat type, does not exceed surrounding mucosa; Recessed implicit type, lower than surrounding mucosa.Rotten to the corn surrounding mucosa often has inflammation to show.There are smooth erosion, rotten to the corn, hemorrhage, the Hypertrophic gastric folds of protuberance or bile reflux etc., visible erythema (point-like, lamellar and strip), the coarse injustice of mucosa, petechia (speckle), mucosa edema under non-atrophic gastritis scope, the basic expressions such as to ooze out.
1.3 criterion of therapeutical effect
1. Short Term Clinical is cured: comprise all indexs below:
1. clinical cardinal symptom disappears, and minor symptom disappears or substantially disappears.
2. gastroscope check Active inflammation disappears, and chronic inflammatory disease is pass on well slightly.
3. biopsy proved by pathology gastroscope finding; Body of gland atrophy, intestinal and dysplasia be normal or disappearance again.
4. gastric acid recovers normal substantially, and bile reflux disappears.
2. effective: to comprise all indexs below:
1. clinical cardinal symptom disappears, and minor symptom disappears substantially.
2. gastroscope check mucosa acute inflammation disappears substantially, and chronic inflammatory disease takes a turn for the better.
3. biopsy proved by pathology gastroscope finding; Body of gland atrophy, intestinal and dysplasia recover or alleviate to reach more than two level degree (containing two level degree).
4. Acid Secretion and bile reflux improve, and reach more than 2/3 of former sick exceptional value.
3. effective: to comprise all indexs below:
1. cardinal symptom obviously alleviates.
2. non-cancer lesion range shorter more than 1/2 is shown in gastroscopy, and inflammation alleviates to some extent.
3. biopsy proved by pathology gastroscope finding; Active chronic inflammation alleviates more than a level degree, body of gland atrophy, and intestinalization life and dysplasia alleviate.
4. Acid Secretion and bile reflux improve, and reach more than 1/2 of former sick exceptional value.
4. invalid: the case not reaching effective standard, but also not deterioration person.
5. worsen: the one having following index:
1. main and minor symptom obviously increases the weight of.
2. gastroscope non-cancer lesion expanded range is to more than 1/2, or pathological changes performance increases the weight of to some extent, or other pathological changes that occurred together.
3. biopsy pathology exacerbate inflammation, body of gland atrophy, intestinal and dysplasia, worsen rising level degree.
4. Acid Secretion and bile reflux worsen, and reach more than 1/2 of former sick exceptional value amount.
1.4 Therapeutic Method and therapeutic effect
1.4.1 treatment group is 3 treatment group 1-3 at random, uses the Chinese medicine composition of the different preparations of embodiment of the present invention 1-3 to treat respectively:
(1) treatment group 1:42 example patient uses the honey refining pill of embodiment 1,2 times on the one, taking 11 time, 7 days is a course for the treatment of, after 1-3 the course for the treatment of of continuous use, drug withdrawal further consultation again in 2 weeks, the routine patient of statistics discovery 26 all fully recovers, and 15 routine patients obviously improve, 1 routine patient is invalid, treatments period does not find other side effect that medicine brings, and follows up a case by regular visits to half a year, all without any the symptom of recurrence.
(2) treatment group 2:42 example patient uses the enema of embodiment 2,3 times on the 1st, once filling with 30 milliliters, 7 days is a course for the treatment of, after continuous coloclysis 1-2 course for the treatment of, drug withdrawal carrys out further consultation in 1 week again, and statistics discovery is all fully recovered, and 16 obviously improve, 2 routine patients are invalid, treatments period does not find other side effect that medicine brings, and follows up a case by regular visits to half a year, all without any the symptom of recurrence.
(3) treatment group 3:42 example patient uses embodiment 3 suppository, 3 times on the one, one time 1, within 7 days, be a course for the treatment of, after 1-3 the course for the treatment of of continuous use, drug withdrawal further consultation again in 1 week, the routine patient of statistics discovery 25 all fully recovers, and 16 routine patients obviously improve, 1 routine patient is invalid, treatments period does not find other side effect that medicine brings, and follows up a case by regular visits to half a year, all without any the symptom of recurrence.
1.4.2 matched group is divided into three matched group 1-3 at random, uses different Western medicine to treat respectively:
(1) matched group 1:58 example patient uses bismuth subcarbonate sheet, a 150g, 3 times on the one, after using 3 months continuously, drug withdrawal further consultation again in 1 week, the routine patient's recovery from illness of statistics discovery 42,6 routine patients obviously improve, 10 routine patients are invalid, follow up a case by regular visits to half a year, and statistics recurs after finding wherein there are 17 routine patient's medicines.
(2) matched group 2:58 person takes bromopride Bromopride, a 2.5-5mg, every day 2-3 time, after taking 1 month continuously, drug withdrawal further consultation again in 1 week, the routine patient's recovery from illness of statistics discovery 39,10 obviously improve, 9 routine patients are invalid, follow up a case by regular visits to half a year, and statistics finds wherein to recur after 10 routine patient's medicines; There is the side effect such as constipation, dyspepsia the used time in other 7 routine patients.
(3) matched group 3:58 person takes proton pump inhibitor, a 0.02g, and every day 3 times, after taking 1 month continuously, drug withdrawal further consultation again in 1 week, the routine patient's recovery from illness of statistics discovery 34,14 routine patients obviously improve, 10 patients are invalid, follow up a case by regular visits to half a year, have recurring condition after the routine patient of statistics discovery 13; There is the side effect such as headache, insomnia in other 5 routine patients when taking.
Known by above-mentioned clinical trial: compared with traditional Western medicine of the chronic non-atrophic gastritis for the treatment of, the Chinese medicine preparation of embodiment of the present invention 1-3 have healing time short, cure after the advantage that not easily recurs and have no side effect.
2, concrete case
Case 1: Zhao, man, 65 years old, retired worker.
Suffer from chronic gastropathy many decades.Gastroscope shows: chronic superficial gastritis.It is not good that patient receives food in recent years, and wrist abdominal distention is vexed, without pantothenic acid, slightly feels night thirsty after food more so, a line soft every day of defecating, light red tongue secretly, too in vain thin, thready pulse is dizzy and weak.
Use the enema of Chinese medicine preparation embodiment 2 of the present invention, 3 times on the 1st, once filling with 30 milliliters, 7 days is a course for the treatment of, after the course for the treatment of of continuous coloclysis, all disease knowing subtract, and appetite slightly, continues 1 course for the treatment of of enema using Chinese medicine preparation embodiment 2 of the present invention, spirit and QI cleaning, appetite increases, and only feels gastral cavilty slightly dull pain once in a while, remaining without uncomfortable.Continue two courses for the treatment of of enema using Chinese medicine preparation embodiment 2 of the present invention, symptom all disappears, and patient fully recovers.
Case 2: journey, female, 37 years old, teacher.
Gastral cavilty portion pain for many years, do again by nearly gastral cavilty portion pain, and feelings will is unsuccessful and fall ill between spring and summer whenever, with distention and fullness in the abdomen when sending out, tired plug in the heart, gas of vomitting is indigestion and loss of appetite is main, before first quarter moon, going on night shift because correcting students' papers, being hindered by omnivorous again, and send out epigastrium distending pain, abdominal distention is vomitted gas, and tired plug does not relax, indigestion and loss of appetite, stool is not smooth, and Western medicine diagnose is chronic gastritis, red tongue, yellow fur, thready and weak pulse is partially dizzy.
The honey taking Chinese medicine preparation embodiment 1 of the present invention refines pill 7, and frequent abdominal distention, painful abdominal mass plug alleviate gradually, if patient is conscious have heavy stone from taking away in the heart.Continue the honey refining pill taking Chinese medicine preparation embodiment 1 of the present invention, 2 times on the one, once taking 1,7 days is a course for the treatment of, continuous two courses for the treatment of, remission.After continuing to take two courses for the treatment of of honey refining pill of Chinese medicine preparation embodiment 1 of the present invention, all diseases are removed entirely, follow up a case by regular visits to and do not recur so far.
Case 3: Hu, female, 19 years old, student.
The gastroscopy of a month cause stomachache row, be diagnosed as chronic superficial gastritis, it is positive that Luo Men imprisons swing arm bacterium.After taking the treatments such as amoxicillin, pain increases the weight of on the contrary, therefore Western medicine of stopping using voluntarily, turn and ask Chinese traditional treatment.Readme stomachache showed effect about every half an hour after meal, though dull pain, each outbreak continued about 1 hour, the swollen slow discomfort of half gastral cavilty, light red tongue, Bian Youchi, yellow and thin fur, thready and rolling pulse.
Take the honey refining pill of Chinese medicine preparation embodiment 1 of the present invention, 2 times on the one, taking 11 time, 7 days is a course for the treatment of, and after taking a course for the treatment of, gastral cavilty distension alleviates, and stomachache is alleviated.The honey continuing to take Chinese medicine preparation embodiment 1 of the present invention refines pill 10, and only, symptom is greatly taken on a new look in stomachache.The honey continuing to take Chinese medicine preparation embodiment 1 of the present invention refines pill after 1 month, transference cure.
Case 4: suddenly certain, man, 57 years old, engineer.
Patient's gastral cavilty portion pain 5 years, increases and is diagnosed as the slight ulcer of chronic gastritis and bulb, temporary must alleviation of taking medicine, and does not fully recover eventually.State of an illness weightening finish in this year, have burning sensation time ailing, fullness in the chest and hypochondrium is vexed, and diet reduces, and belch is frequent, and borborygmus rings, and body and the spirit is tired, famine then pain very, the sweet then pain of food heat food is slow, greasy and thin fur and slightly yellow, arteries and veins is dizzy carefully unable.
Use the suppository of Chinese medicine preparation embodiment 3 of the present invention, 3 times on the one, one time 1, within 7 days, be a course for the treatment of, use 2 courses for the treatment of continuously, pain relief, to get a breathing space minimizing, borborygmus rings and stops, and after continuing the course for the treatment of of suppository using Chinese medicine preparation embodiment 3 of the present invention, symptom continues to alleviate, diet increases, continue to use the suppository of Chinese medicine preparation embodiment 3 of the present invention after 2 months, all diseases are removed entirely, again do not recur.
Case 5: rope, man, 45 years old, manager.
Epigastric distending pain 6 ~ 8 months, doctor examines chronic hypertrophic gastritis.First have no positive effect with western medicine 5 wheat harvesting period, continue and coordinate Chinese medicine invigorating the spleen and regulating the stomach, warming middle-JIAO and strengthening the spleen etc. without obviously changing.Sift its disease, pain is based on the epigastrium below xiphoid-process, and very, tongue fur is white, floating-rolling pulse for feeling pain while pressing.
Use the enema of Chinese medicine preparation embodiment 2 of the present invention, 3 times on the 1st, once fill with 30 milliliters, within 7 days, be a course for the treatment of, after using continuously 1 course for the treatment of of described enema, pain is greatly extenuated, after continuing 1 course for the treatment of of use again, slight illness is greatly alleviated, and continues the enema 2 using Chinese medicine preparation embodiment 2 of the present invention, and pain is even to be done, symptom is greatly taken on a new look, continue a course for the treatment of of use, pain disappears, and patient fully recovers.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent to replace, enter, all should be included within protection scope of the present invention.
Claims (4)
1. treat the Chinese medicine preparation of chronic non-atrophic gastritis for one kind, it is characterized in that, in described Chinese medicine preparation, the mass fraction of various crude drug is: Radix Glehniae 10 ~ 30 parts, Radix Ophiopogonis 15 ~ 30 parts, Radix Angelicae Sinensis 10 ~ 30 parts, 10 ~ 30 parts, the Radix Rehmanniae, Fructus Lycii 10 ~ 25 parts, Fructus Toosendan 15 ~ 30 parts, the Radix Paeoniae Alba 10 ~ 30 parts, Radix Glycyrrhizae Preparata 15 ~ 30 parts, Margarita powder 10 ~ 25 parts, Concha Ostreae 10 ~ 30 parts, Endoconcha Sepiae 10 ~ 25 parts, Cortex Magnoliae Officinalis 10 ~ 25 parts, Flos Rosae Rugosae 10 ~ 25 parts, Fructus Citri Sarcodactylis 10 ~ 30 parts, Fructus Cannabis 10 ~ 30 parts, Semen Trichosanthis 10 ~ 30 parts, Herba Dendrobii 10 ~ 25 parts, the Rhizoma Anemarrhenae 10 ~ 30 parts, Rhizoma Coptidis 10 ~ 30 parts, Rhodobryum roseum Limpr. 10 ~ 35 parts, Limax 10 ~ 30 parts, Herba Melastomatis dodecandri 10 ~ 25 parts.
2. the Chinese medicine preparation of the chronic non-atrophic gastritis for the treatment of according to claim 1, it is characterized in that, in described Chinese medicine preparation, the mass fraction of various crude drug is: described Radix Glehniae 15 ~ 25 parts, Radix Ophiopogonis 16 ~ 25 parts, Radix Angelicae Sinensis 15 ~ 25 parts, 15 ~ 25 parts, the Radix Rehmanniae, Fructus Lycii 15 ~ 20 parts, Fructus Toosendan 15 ~ 25 parts, the Radix Paeoniae Alba 15 ~ 25 parts, Radix Glycyrrhizae Preparata 15 ~ 25 parts, Margarita powder 15 ~ 20 parts, Concha Ostreae 15 ~ 25 parts, Endoconcha Sepiae 15 ~ 25 parts, Cortex Magnoliae Officinalis 15 ~ 25 parts, Flos Rosae Rugosae 15 ~ 25 parts, Fructus Citri Sarcodactylis 15 ~ 25 parts, Fructus Cannabis 15 ~ 25 parts, Semen Trichosanthis 15 ~ 25 parts, Herba Dendrobii 15 ~ 25 parts, the Rhizoma Anemarrhenae 15 ~ 25 parts, Rhizoma Coptidis 15 ~ 25 parts, Rhodobryum roseum Limpr. 15 ~ 30 parts, Limax 15 ~ 25 parts, Herba Melastomatis dodecandri 15 ~ 20 parts.
3. the Chinese medicine preparation of the chronic non-atrophic gastritis for the treatment of according to claim 1 and 2, it is characterized in that, in described Chinese medicine preparation, the mass fraction of various crude drug is: described Radix Glehniae 18 ~ 20 parts, Radix Ophiopogonis 18 ~ 25 parts, Radix Angelicae Sinensis 16 ~ 20 parts, 18 ~ 20 parts, the Radix Rehmanniae, Fructus Lycii 16 ~ 18 parts, Fructus Toosendan 18 ~ 20 parts, the Radix Paeoniae Alba 16 ~ 20 parts, Radix Glycyrrhizae Preparata 18 ~ 20 parts, Margarita powder 16 ~ 18 parts, Concha Ostreae 16 ~ 18 parts, Endoconcha Sepiae 16 ~ 20 parts, Cortex Magnoliae Officinalis 16 ~ 20 parts, Flos Rosae Rugosae 18 ~ 20 parts, Fructus Citri Sarcodactylis 16 ~ 20 parts, Fructus Cannabis 18 ~ 20 parts, Semen Trichosanthis 16 ~ 20 parts, Herba Dendrobii 18 ~ 20 parts, the Rhizoma Anemarrhenae 16 ~ 20 parts, Rhizoma Coptidis 16 ~ 20 parts, Rhodobryum roseum Limpr. 15 ~ 20 parts, Limax 18 ~ 20 parts, Herba Melastomatis dodecandri 18 ~ 20 parts.
4. the preparation method of the Chinese medicine preparation of the chronic non-atrophic gastritis of the treatment according to claim 1-3 any one, it is characterized in that, described Chinese medicine preparation is enema, and described enema preparation process is:
A, get crude drug and soak 1.5 hours, extract twice, each 1-1.5 hour, merge extractive liquid, filter, medicinal residues are for subsequent use, and during filtrate reduced in volume to 85 DEG C, relative density is the extractum shape of 1.36, obtains extractum 1;
B, the medicinal residues of step a are added 5-8 times amount alcoholic degree is the ethanol of 70%-90%, soak 1-1.5 hour, then twice is extracted, each 1-1.5 hour, merge extractive liquid, 80-140 order filters, 6000-10000 rev/min centrifugal after supernatant is the ultrafiltration post ultrafiltration of 6000-13000 through current-carrying molecular weight, when ultrafiltrate concentrating under reduced pressure obtains 85 DEG C, relative density is the extractum 2 of 1.32;
C, by extractum 1 and extractum 2 mix homogeneously, then thin up, obtains enema.
Applications Claiming Priority (1)
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| CN201310511842.9A Expired - Fee Related CN103520518B (en) | 2013-10-25 | 2013-10-25 | A kind ofly treat Chinese medicine preparation of chronic non-atrophic gastritis and preparation method thereof |
| CN201510522872.9A Withdrawn CN105055904A (en) | 2013-10-25 | 2013-10-25 | Chinese herbal preparation for treating chronic non-atrophic gastritis and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456545A (en) * | 2016-01-25 | 2016-04-06 | 闵卫 | Medicine for treating stomach flatulence |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104367886A (en) * | 2014-11-08 | 2015-02-25 | 全椒县尹氏油脂有限公司 | Traditional Chinese medicine for treating chronic gastritis |
| CN104524431B (en) * | 2014-12-07 | 2015-10-07 | 青岛大学附属医院 | A kind of Chinese medicine composition for the treatment of gastropathy |
| CN114404549B (en) * | 2022-01-29 | 2022-11-29 | 南京中医药大学 | Traditional Chinese medicine composition for treating chronic atrophic gastritis and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101766782A (en) * | 2010-04-08 | 2010-07-07 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicine composite for treating chronic gastritis and preparation method thereof |
| CN102772670A (en) * | 2012-08-17 | 2012-11-14 | 张守实 | Traditional Chinese medicine composition for treating superficial gastritis |
| CN103316245A (en) * | 2013-07-01 | 2013-09-25 | 梁怡芃 | Chinese medicine preparation for treating infantile enuresis and preparation method thereof |
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| CN1238040C (en) * | 2003-08-14 | 2006-01-25 | 山东大海集团有限公司 | Preparation of weiping capsule for treating stomach disease |
| CN102846939A (en) * | 2012-08-31 | 2013-01-02 | 李承平 | Tablets with functions of kidney tonifying and liver nourishing |
| CN103623388B (en) * | 2013-12-23 | 2016-01-06 | 李�杰 | A kind of Chinese medicine preparation for the treatment of chronic gastritis and preparation method thereof |
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- 2013-10-25 CN CN201510522829.2A patent/CN105012714A/en not_active Withdrawn
- 2013-10-25 CN CN201310511842.9A patent/CN103520518B/en not_active Expired - Fee Related
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101766782A (en) * | 2010-04-08 | 2010-07-07 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicine composite for treating chronic gastritis and preparation method thereof |
| CN102772670A (en) * | 2012-08-17 | 2012-11-14 | 张守实 | Traditional Chinese medicine composition for treating superficial gastritis |
| CN103316245A (en) * | 2013-07-01 | 2013-09-25 | 梁怡芃 | Chinese medicine preparation for treating infantile enuresis and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456545A (en) * | 2016-01-25 | 2016-04-06 | 闵卫 | Medicine for treating stomach flatulence |
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| CN103520518A (en) | 2014-01-22 |
| CN105012714A (en) | 2015-11-04 |
| CN103520518B (en) | 2016-03-30 |
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Application publication date: 20151118 |