CN102847047B

CN102847047B - Medicine for treating chronic gastritis and preparation method thereof

Info

Publication number: CN102847047B
Application number: CN201210361142.1A
Authority: CN
Inventors: 张永红
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-09-26
Filing date: 2012-09-26
Publication date: 2014-04-09
Anticipated expiration: 2032-09-26
Also published as: CN102847047A

Abstract

The invention discloses a medicine for treating chronic gastritis and a preparation method of the medicine. The medicine is mainly prepared by the ingredients such as liquorice, smoked plum, codonopsis pilosula, polyporus lucidus, trogopterus dung, radix polygonati officinalis, rhizoma nardostachyos, pericarpium citri reticulatae and pinellia ternata according to a certain weight proportion. The medicine provided by the invention has functions of tonifying spleen and harmonizing stomach and enhancing qi while nourishing fluid, is used for treating the chronic gastritis, and is rapid in effect taking, short in treatment course and free of relapse.

Description

A kind of medicine for the treatment of chronic gastritis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of chronic gastritis and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Chronic gastritis generally refers to chronic superficial gastritis and chronic atrophic gastritis.After gastric ulcer, polyp of stomach and gastric cancer are often secondary to chronic gastritis, relation is very close each other.In the gastral cavity of a lot of chronic gastritiss, have bile to retain, this is due to musculus sphincter pyloricus functional disorder, and bile reflux enters the cause of stomach.Cholate can weaken the gastric mucosal barrier function penetrating to ion, makes hydrion back diffusion in gastric juice enter gastric mucosa, the pathological changes that causes inflammation, and long-term bile reflux certainly will cause chronic gastritis or gastric ulcer.Eating and drinking too much at one meal, psychentonia all easily causes gastrointestinal dysfunction, and food is smouldered at gastric, is so just easy to form chronic superficial gastritis.Western medical treatment is that primary and secondary effect is larger mainly with antibiotic medicine, and therefore, people exist great demand to the Chinese medicine of effective treatment chronic gastritis.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective treatment chronic gastritis, thereby has completed the present invention.

Object of the present invention is just to provide a kind of composition of medicine that can treat chronic gastritis.

Another object of the present invention has just been to provide the preparation method of this composition of medicine.

Medicine of the present invention selects Radix Glycyrrhizae, Fructus Mume, Radix Codonopsis, Ganoderma lucidum seu Japonicum, Oletum Trogopterori, Rhizoma Polygonati Odorati, Radix Et Rhizoma Nardostachyos, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, the Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, the Radix Linderae, crystal sugar, Cortex Cinnamomi, Fructus Citri Sarcodactylis, Fructus Aurantii, Fructus Amomi Rotundus, Fructus Jujubae, the Rhizoma Atractylodis Macrocephalae, Radix Cynanchi Paniculati and Massa Medicata Fermentata to combine, make each efficacy of drugs produce synergism these drug regimens, thus recurrence that can fast treating chronic gastritis.Wherein select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Select Fructus Mume to be because its nature and flavor are sour, temperature, enters liver, spleen, and lung, large intestine channel, has convergence to promote the production of body fluid, and the function of relieving colic caused by ascaris anthelmintic, controls chronic cough, deficiency-heat excessive thirst, chronic malaria, dysentery, has blood in stool, hematuria, metrorrhagia, ascariasis of biliary tract stomachache, vomiting, ancylostomiasis, psoriasis, bulbar conjunctiva polyp.Select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, meridian of Foot-TAI YIN edema caused by disorder of QI, have invigorating the spleen and replenishing QI, the function of promoting the production of body fluid, controls weakness of the spleen and stomach, deficiency of both QI and blood, and fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.Select Ganoderma lucidum seu Japonicum to be because its nature and flavor are sweet, flat, control asthenia, cough, asthma, insomnia, dyspepsia.Selecting Oletum Trogopterori is that temperature, enters liver, spleen channel because of its property bitter but sweet flavor, and the raw function with there being promoting the circulation of blood pain relieving, controls all pains of trusted subordinate's vim and vigour, women's amenorrhea, and postnatal blood stasis is had a pain; External treatment Serpentis, scorpion, centipete bite, fry with hemostasis, controls metrorrhagia, menorrhagia, and leucorrhea with bloody discharge is without cease.Select Rhizoma Polygonati Odorati to be because its nature and flavor are sweet, flat, enter lung, stomach warp, has yin nourishing, moisturizes, relieving restlessness, the function of quenching the thirst, controls calentura sun wound, cough, excessive thirst, deficient fever, rapid digestion of food is easily hungry, frequent micturition.Select Radix Et Rhizoma Nardostachyos to be because its nature and flavor are sweet, temperature, enters spleen, stomach warp, has regulating QI to relieve pain, and activating spleen and strengthening stomach, treats for stomachache, distension and fullness of the chest and abdomen, headache, hysteria, beriberi.Select Pericarpium Citri Reticulatae to be because its nature and flavor are bitter, pungent, temperature, returns lung, spleen channel, has regulating qi-flowing for strengthening spleen, and the function of drying dampness to eliminate phlegm, controls fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Select the Rhizoma Pinelliae to be because its nature and flavor are pungent, temperature, poisonous, enter spleen, stomach warp, there is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass, controls damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm headache, dizzy sleeplessness, outer subduing inflammation.Select the Radix Astragali to be because its nature and flavor are sweet, tepor, enters lung, spleen channel, raw with the useful consolidating superficial resistance of defending, inducing diuresis to remove edema, and poison holding, the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle is not burst or is burst and hold back for a long time; Process by the function that has invigorating middle warmer benefit, control internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Radix Trichosanthis to be because its nature and flavor sweetness and bitterness acid is cool, enter lung, stomach warp, have and promote the production of body fluid, quench the thirst, pathogenic fire reducing, moisturizes, evacuation of pus, and the function of detumescence, controls calentura thirsty, quenches one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid complicated by anal fistula.With being Radix Ophiopogonis, because its property sweet and slightly bitter taste is cold, enter lung, stomach, heart channel, have nourishing YIN and moistening the lung, the relieving restlessness that clears away heart-fire, the function of reinforcing stomach reg fluid, controls dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, thirsty clearly, calentura Tianjin wound, dry mouth and throat, constipation.Select the Radix Linderae to be because its nature and flavor are pungent, temperature, enters spleen, lung, kidney, urinary bladder channel, have pleasant, dissipating depression of QI, cold expelling, the function of pain relieving, controls QI rising in reverse order chest and abdomen swelling and pain, dyspepsia is discontented, food is told in regurgitation, colic of cold type, beriberi, frequent micturition.Select crystal sugar to be because its nature and flavor are sweet, property is flat, nontoxic, enters spleen, lung two warps, has invigorating the spleen and replenishing QI, and the function of stomach function regulating lung moistening, controls cough-relieving and cough, and saliva reduces phlegm.Selecting Cortex Cinnamomi is that heat, enters kidney, spleen, urinary bladder channel because of its property acrid-sweet flavor, has complement sun, warming the spleen and stomach, removing accumulated cold, the function of promoting blood circulation, controls decline of the fire from the gate of life, cold extremities faint pulse, and YANG-depletion collapse, stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.Select Fructus Citri Sarcodactylis, different name Fructus Citri Sarcodactylis, Bergamot, be because the arduous acid of its nature and flavor, and temperature, enters liver, stomach warp, regulates the flow of vital energy, and the function of reducing phlegm, treats for stomachache, coerce swollen, vomiting, dysphagic, phlegm retention cough with asthma, and relieving the effect of alcohol.Selecting Fructus Aurantii is because its nature and flavor toil, cool, enters lung, spleen, large intestine channel, has dispelling the stagnated QI, row expectorant, the function of removing food stagnancy, controls chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.Select Fructus Amomi Rotundus be because its nature and flavor pungent, temperature, enters lung, spleen channel, has sector-style, warming the stomach, helps digestion, the function of alleviating distention in middle-JIAO, controls the stagnation of QI, dyspepsia is uncomfortable in chest, abdominal distention, eructation, dysphagic, tell contrary, regurgitation, malaria.Select Fructus Jujubae to be because its nature and flavor are sweet, temperature, enters spleen, stomach warp, has spleen reinforcing stomach function regulating, and supplementing QI for promoting the production of body fluid adjusts battalion to defend, and separates the function of poison of drug, controls insufficiency of stomach lack of appetite, the weak loose stool of spleen, and qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation, woman hysteria.Selecting the Rhizoma Atractylodis Macrocephalae is because its property bitter but sweet flavor, and temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea is uneasy.Select Radix Cynanchi Paniculati to be because its nature and flavor are pungent, temperature, has analgesia, cough-relieving, and inducing diuresis to remove edema, the function of promoting blood circulation and detoxication, treats for stomachache, toothache, rheumatalgia, abdominal pain in menstruation, chronic tracheitis, ascites, edema, dysentery, enteritis, traumatic injury, eczema, urticaria, venom.Select Massa Medicata Fermentata to be because its nature and flavor sweet, acrid, warm enters upright stone tablet, stomach warp, have invigorating the spleen and regulating the stomach, the function helping digestion in adjusting, controls retention of food and drink, feeling of stuffiness in chest abdominal distention, and vomiting dysentery, postnatal blood stasis stomachache, children's's enlarged abdomen is hard long-pending.

The specific embodiment

The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Radix Glycyrrhizae 4-10 gram of Fructus Mume 10-20 gram of Radix Codonopsis 10-26 gram

Ganoderma lucidum seu Japonicum 4-16 gram of Oletum Trogopterori 9-14 gram of Rhizoma Polygonati Odorati 4-13 gram

Radix Et Rhizoma Nardostachyos 8-18 gram of Pericarpium Citri Reticulatae 5-19 gram of Rhizoma Pinelliae 2-9 gram

Radix Astragali 8-10 gram Radix Trichosanthis 8-18 gram Radix Ophiopogonis 10-20 gram

Radix Linderae 5-19 gram of crystal sugar 6-12 gram of Cortex Cinnamomi 8-12 gram

Fructus Citri Sarcodactylis 4-10 gram of Fructus Aurantii 8-20 gram of Fructus Amomi Rotundus 2-10 gram

Fructus Jujubae 8-20 gram of Rhizoma Atractylodis Macrocephalae 6-12 gram of Radix Cynanchi Paniculati 8-20 gram

Massa Medicata Fermentata 5-12 gram

Wherein, be preferably

18 grams of 15 grams of Radix Codonopsis of 6 grams of Fructus Mumes of Radix Glycyrrhizae

8 grams of 10 grams of Rhizoma Polygonati Odorati of 12 grams of Oletum Trogopteroris of Ganoderma lucidum seu Japonicum

5 grams of 12 grams of Rhizoma Pinelliaes of 10 grams of Pericarpium Citri Reticulataes of Radix Et Rhizoma Nardostachyos

15 grams of 10 grams of Radix Trichosanthis of the Radix Astragali 10 grams of Radix Ophiopogonis

10 grams of 8 grams of Cortex Cinnamomis of 8 grams of crystal sugar of the Radix Linderae

8 grams of 10 grams of Fructus Amomi Rotunduss of 8 grams of Fructus Aurantiis of Fructus Citri Sarcodactylis

10 grams of 8 grams of Radix Cynanchi Paniculatis of 10 grams of Rhizoma Atractylodis Macrocephalaes of Fructus Jujubae

8 grams of Massa Medicata Fermentata

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly time to eighty per cant, run through section, airing;

2, Fructus Mume: choose clean impurity, sieve dedust bits, clean, and dry;

3, Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;

4, Ganoderma lucidum seu Japonicum: remove impurity, clean, soften, cut sheet, dry, sieve removes chip;

5, Oletum Trogopterori: choose clean impurity, smash or sieve dedust bits;

6, Rhizoma Polygonati Odorati: remove impurity, clean earth, moistening is even to inside and outside humidity, and section, dries;

7, Radix Et Rhizoma Nardostachyos: Ex-all impurity, rob water speed and wash, to pull out, cutting, dries;

8, Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, softens, and shredding, dries or cold drying, sieve dedust bits;

9, the Rhizoma Pinelliae: choose decontamination, sieve dedust bits;

10, the Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear section, dry;

11, Radix Trichosanthis: choose decontamination, size block separately, saturating with blister approximately sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries, or wash, and pulls out, shines extremely dryly, smashes into fritter;

12, Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, pump the heart after running through, then clean and dry;

13, the Radix Linderae: choose decontamination, size bar separately, water soaks, and according to noting changing water season, prevents smellyly, pulls in time section out, dries sieve dedust bits;

14, crystal sugar: get crude drug, choose clean impurity;

15, Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the used time smashes, or scrape off rough bark, by warm water, infiltrating a moment, section, dries;

16, Fructus Citri Sarcodactylis: choose decontamination, after water spray profit, chopping, dries;

17, Fructus Aurantii: remove flesh, core, edulcoration, slightly soaks, and pulls out, softens, the hands of take can be pinched doubling as degree, and section, dries;

18, Fructus Amomi Rotundus: choose clean impurity, sieve scurf removing, smashes, or peel off shell, gets core and smashes use;

19, Fructus Jujubae: choose clean impurity, dry;

20, the Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out after bubble, run through, section, dries;

21, Radix Cynanchi Paniculati: choose clean impurity, clean, run through, be cut into 1.5 centimetres of sections, dry;

22, Massa Medicata Fermentata: get wheat bran and sprinkle evenly in heat pot, the cigarette of having waited, pours Massa Medicata Fermentata into, fries to yellow, takes out, and sieve removes wheat bran, cools.

Two, preparation

1, the Radix Glycyrrhizae of described weight, Fructus Mume, Radix Codonopsis, Ganoderma lucidum seu Japonicum, Oletum Trogopterori, Rhizoma Polygonati Odorati, Radix Et Rhizoma Nardostachyos, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, the Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, the Radix Linderae, crystal sugar, Cortex Cinnamomi, Fructus Citri Sarcodactylis, Fructus Aurantii, Fructus Amomi Rotundus, Fructus Jujubae, the Rhizoma Atractylodis Macrocephalae, Radix Cynanchi Paniculati, Massa Medicata Fermentata medicine being added to 6 times of amounts of water soaks, intense fire decocts boiling 20 minutes, use again slow fire boiling 15 minutes, filter, obtain decoction liquor for the first time.

2, medicinal residues are added to 3 times of amounts of water, intense fire decocts boiling, then uses slow fire boiling 15 minutes, filters, and obtains decoction liquor for the second time.

3, twice decoction liquor merged, intense fire is fried boiling, then uses slow fire boiling 10 minutes, is divided into two doses.

Medicine of the present invention has spleen reinforcing stomach function regulating, the function of supplementing QI for promoting the production of body fluid.Treatment chronic gastritis instant effect, short treating period, do not recur.

By test example, further set forth below the beneficial effect of medicine of the present invention, these tests comprise animal toxicity test and the clinical observation test of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get 20 of rabbit, male and female dual-purpose, body weight 2.0-2.5kg, divides two groups, and 10 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day twice, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's 150 examples for medical treatment.

2, diagnostic criteria

The cardinal symptom of chronic gastritis is that the pain of stomach is main.Pain has distending pain, twinge, dull pain, dull pain etc.　

3, Therapeutic Method

Select above-mentioned medicament, every day 2 times, each 1 dose 15 days is a course for the treatment of, takes continuously two courses for the treatment of.Period in a medicine, note life, diet wants rule, does not eat zest, the peracid such as pungent, crosses sweet food thing.

4, efficacy assessment standard

Effective: clinical symptom disappearance after treatment, gastritis recovery from illness, it is normal that patient's body constitution is recovered, and observes half a year without recidivist;

Take a turn for the better: clinical symptoms is obviously improved, and body constitution is progressively recovered;

Invalid: clinical partial symptoms disappears or without change, do not reach improvement standard person.

5, therapeutic outcome

In above-mentioned treatment, by Drug therapy Patients with Chronic Gastritis 150 examples of the present invention, effective 145 examples of result, obvious effective rate is 96.67%, 3 examples that take a turn for the better, and improvement rate is 2%, invalid 2 examples, total effective rate is 98.67%.

Claims

1. a medicine for the treatment of chronic gastritis, is characterized in that: it is to be made by the crude drug in following weight range:

Massa Medicata Fermentata 5-12 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

8 grams of Massa Medicata Fermentata.

3. according to a preparation method for medicine described in claim 1 or 2, it comprises the following steps:

(1) get the raw materials ready

(1) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly time to eighty per cant, run through, section, dries;

(2) Fructus Mume: choose clean impurity, sieve dedust bits, clean, and dry;

(3) Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;

(4) Ganoderma lucidum seu Japonicum: remove impurity, clean, soften, cut sheet, dry, sieve removes chip;

(5) Oletum Trogopterori: choose clean impurity, smash or sieve dedust bits;

(6) Rhizoma Polygonati Odorati: remove impurity, clean earth, moistening is even to inside and outside humidity, and section, dries;

(7) Radix Et Rhizoma Nardostachyos: Ex-all impurity, rob water speed and wash, to pull out, cutting, dries;

(8) Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, softens, and shredding, dries or cold drying, sieve dedust bits;

(9) Rhizoma Pinelliae: choose decontamination, sieve dedust bits;

(10) Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear section, dry;

(11) Radix Trichosanthis: choose decontamination, size block separately, saturating with blister approximately sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries, or wash, and pulls out, shines extremely dryly, smashes into fritter;

(12) Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, pump the heart after running through, then clean and dry;

(13) Radix Linderae: choose decontamination, size bar separately, water soaks, and according to noting changing water season, prevents smellyly, pulls in time section out, dries sieve dedust bits;

(14) crystal sugar: get crude drug, choose clean impurity;

(15) Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the used time smashes, or scrape off rough bark, by warm water, infiltrating a moment, section, dries;

(16) Fructus Citri Sarcodactylis: choose decontamination, after water spray profit, chopping, dries;

(17) Fructus Aurantii: remove flesh, core, clean, slightly soak, pull out, soften, the hands of take can be pinched doubling as degree, and section, dries;

(18) Fructus Amomi Rotundus: choose clean impurity, sieve scurf removing, smashes, or peel off shell, gets core and smashes use;

(19) Fructus Jujubae: choose clean impurity, dry;

(20) Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out after bubble, run through, section, dries;

(21) Radix Cynanchi Paniculati: choose clean impurity, clean, run through, be cut into 1.5 centimetres of sections, dry;

(22) Massa Medicata Fermentata: get wheat bran and sprinkle evenly in heat pot, the cigarette of having waited, pours Massa Medicata Fermentata into, fries to yellow, takes out, and sieve removes wheat bran, cools;

(2) preparation

(1) Radix Glycyrrhizae of described weight, Fructus Mume, Radix Codonopsis, Ganoderma lucidum seu Japonicum, Oletum Trogopterori, Rhizoma Polygonati Odorati, Radix Et Rhizoma Nardostachyos, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, the Radix Astragali, Radix Trichosanthis, Radix Ophiopogonis, the Radix Linderae, crystal sugar, Cortex Cinnamomi, Fructus Citri Sarcodactylis, Fructus Aurantii, Fructus Amomi Rotundus, Fructus Jujubae, the Rhizoma Atractylodis Macrocephalae, Radix Cynanchi Paniculati, Massa Medicata Fermentata medicine being added to 6 times of amounts of water soaks, intense fire decocts boiling 20 minutes, use again slow fire boiling 15 minutes, filter, obtain decoction liquor for the first time;

(2) medicinal residues are added to 3 times of amounts of water, intense fire decocts boiling, then uses slow fire boiling 15 minutes, filters, and obtains decoction liquor for the second time;

(3) twice decoction liquor merged, intense fire is fried boiling, then uses slow fire boiling 10 minutes, is divided into two doses.