CN102772693B - Medicine for treating recurrent oral ulcer and preparation method thereof - Google Patents

Medicine for treating recurrent oral ulcer and preparation method thereof Download PDF

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CN102772693B
CN102772693B CN 201210297173 CN201210297173A CN102772693B CN 102772693 B CN102772693 B CN 102772693B CN 201210297173 CN201210297173 CN 201210297173 CN 201210297173 A CN201210297173 A CN 201210297173A CN 102772693 B CN102772693 B CN 102772693B
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rhizoma
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radix
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CN102772693A (en
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孙凤梅
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孙凤梅
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Abstract

The invention discloses a medicine for treating recurrent oral ulcer and a preparation method thereof. The medicine is mainly prepared from rhizoma alismatis, rhizoma coptidis, lotus plumule, liquorice, radix ophiopogonis and rhizoma phragmitis according to certain weight proportions. The medicine disclosed by the invention has the functions of clearing away the accumulated heat in the heart and spleen and tonifying and replenishing qi and blood, takes an effect quickly on treating recurrent oral ulcer, and has a good curative effect and a high cure rate.

Description

A kind of medicine for the treatment of recurrent oral ulceration and preparation method thereof
Technical field
The present invention relates to a kind of medicine for the treatment of recurrent oral ulceration and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Recurrent oral ulceration is a kind of oral mucosal disease, with oral mucosa circle or oval aphtha takes place repeatedly, and scorching hot pain is arranged is feature, be called again " aphtha " among the people, general 7~10 days of the course of disease.If down here, the course of disease is longer, sustainable several years or many decades.Send out the author repeatedly, ulcer can increase, increase.At present, because Western medicine can't effectively be treated recurrent oral ulceration, and has certain side effect, therefore, there is very big demand in people to the Chinese medicine of effective treatment recurrent oral ulceration.
Summary of the invention
The inventor has found the medicine of effective treatment recurrent oral ulceration finally, thereby has finished the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.
Purpose of the present invention just provides a kind of composition of medicine that can treat recurrent oral ulceration.
Another object of the present invention has just provided the preparation method of this composition of medicine.
Medicine of the present invention selects Rhizoma Alismatis, Rhizoma Coptidis, Plumula Nelumbinis, Fructus Gardeniae, Poria, Radix Scutellariae, Radix Rehmanniae, Radix Glycyrrhizae, Radix Ophiopogonis, Caulis Akebiae, Folium Bambusae, Rhizoma Imperatae, Rhizoma Phragmitis, Fructus Ligustri Lucidi and Cortex Lycii to make up, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of recurrent oral ulceration.Wherein select for use Rhizoma Alismatis to be because its nature and flavor are sweet, cold, go into urinary bladder channel, diuretic is arranged, eliminating dampness by diuresis, the function that expels the heat-evil is controlled dysuria, and the edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Select for use Rhizoma Coptidis to be because its nature and flavor hardship is cold, go into the heart, liver, stomach, large intestine channel, pathogenic fire purging is arranged, dampness, detoxifcation, the function of parasite killing, row pyretic toxicity, typhoid fever when controlling, intenseness of heat is vexed, feeling of fullness vomiting, bacillary dysentery, diarrhea of heat type stomachache, pulmonary tuberculosis is told, nosebleed, hematochezia, quenches one's thirst infantile malnutrition, ascariasis, pertussis, laryngopharynx swelling and pain, acute catarrhal conjunctivitis, aphtha, skin sore, eczema, the burning hot wound of soup.Selecting Plumula Nelumbinis for use is because its nature and flavor hardship, cold, goes into the heart, lung, kidney three warps, has to clear away heart-fire, reduce phlegm and internal heat, and hemostasis, the function of arresting seminal emission is controlled vexedly, thirsty, spits blood seminal emission, conjunctival congestion and swelling pain.Select for use Fructus Gardeniae to be because its nature and flavor hardship is cold, go into the heart, liver, lung, stomach warp, heat clearing away is arranged, pathogenic fire purging, the function of removing heat from blood is controlled the calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea is quenched one's thirst, conjunctival congestion, pharyngalgia is spitted blood, epistaxis, dysentery, hematuria, pathopyretic ulcer is sprained and is swollen and ache.Select for use Poria to be because its property slightly sweet flavor is flat, go into the heart, spleen, lung meridian, eliminating dampness and diuresis is arranged, the strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming is controlled dysuria edema distending pain, the phlegm retention cough with dyspnea, the sound of vomiting of vomitting is had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Select for use Radix Scutellariae to be because its nature and flavor bitter cold is gone into cardiopulmonary, gallbladder, large intestine channel, the removing the relative excess fire is arranged, except damp and hot, the function of arresting bleeding and miscarriage prevention is controlled the high fever excessive thirst, the cough due to lung-heat.Select for use Radix Rehmanniae to be because its nature and flavor are sweet, cold, GUIXIN, liver, kidney channel have clearing away heat and cooling blood, yin nourishing, and the function of promoting the production of body fluid is controlled the calentura excessive thirst, interior-heat caused by deficiency of YIN, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis is sent out the speckle dermexanthesis.Select for use Radix Glycyrrhizae to be because its nature and flavor are sweet flat, go into spleen, stomach, lung meridian, have and middle emergency, lung moistening, detoxifcation, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, the overstrain heating, consumptive lung disease cough, cardiopalmus, frightened carbuncle is given birth to controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.Select for use be Radix Ophiopogonis because its property sweet and slightly bitter taste is cold, go into lung, stomach, heart channel, nourishing YIN and moistening the lung is arranged, the relieving restlessness that clears away heart-fire, the function of reinforcing stomach reg fluid is controlled dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, the asthenia dysphoria with smothery sensation, clear thirsty, hinder in calentura Tianjin, dry mouth and throat, constipation.Selecting Caulis Akebiae for use is that the heart, small intestinal, urinary bladder channel are gone in cold, and pathogenic fire purging row water is arranged because of its nature and flavor hardship, and the function of promoting blood circulation is controlled hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis.Selecting Folium Bambusae for use is because its property slightly sweet flavor, cold, goes into the heart, lung, gallbladder, stomach warp, and clearing heat and relieving fidgetness is arranged, and the function of the diuresis of promoting the production of body fluid controls that calentura is tired drinks, and little youngster shies Epilepsy, and cough with dyspnea is told nosebleed, flushed complexion, oliguria with reddish urine, erosion of the oral mucosa tongue boil.It is sweet because of its nature and flavor, cold selecting Rhizoma Imperatae for use, goes into lung, stomach, small intestine meridian, and removing heat from blood is arranged, hemostasis, and heat clearing away, the function of diuresis is controlled the calentura excessive thirst, spits blood epistaxis, lung-heat dyspnea with rapid respiration, gastric heat hiccup, gonorrhea, dysuria, edema, jaundice.Select for use Rhizoma Phragmitis to be because its nature and flavor are sweet, cold, go into lung, the stomach warp has heat clearing away, promotes the production of body fluid, relieving restlessness, the function of preventing or arresting vomiting is controlled the calentura excessive thirst, and gastropyretic vomiting is dysphagic, regurgitation, consumptive lung disease, lung abscess, and separate Fugu ocellatus ichthyotoxin.Select for use Fructus Ligustri Lucidi to be because its property bitter but sweet flavor is flat, go into liver, kidney channel, invigorating the liver and kidney is arranged, the function of strong waist knee joint is controlled interior-heat caused by deficiency of YIN, dizziness, order flower tinnitus, soreness of the waist and knees, early whitening of beard and hair.Select for use Cortex Lycii to be because its nature and flavor are sweet, cold, go into lung, liver, kidney channel, heat clearing away is arranged, the function of removing heat from blood is controlled asthenia hectic fever night sweat, and the lung-heat cough with asthma is spitted blood, epistaxis, stranguria with blood is quenched one's thirst, hypertension, carbuncle, malignant boil.
The specific embodiment
The drug dose of the present invention's combination also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has better curative effect in following weight range
Rhizoma Alismatis 5-15 gram Rhizoma Coptidis 2-15 gram Plumula Nelumbinis 3-10 gram
Fructus Gardeniae 8-20 gram Poria 3-14 gram Radix Scutellariae 5-12 gram
Radix Rehmanniae 6-18 gram Radix Glycyrrhizae 3-12 gram 6-12 Radix Ophiopogonis gram
Caulis Akebiae 3-12 gram Folium Bambusae 2-12 gram Rhizoma Imperatae 20-40 gram
Rhizoma Phragmitis 20-45 gram Fructus Ligustri Lucidi 5-15 gram Cortex Lycii 5-12 gram
Wherein, be preferably
Rhizoma Alismatis 10 gram Rhizoma Coptidis 6 gram Plumula Nelumbiniss 5 grams
Fructus Gardeniae 10 gram Poria 10 gram Radix Scutellariaes 10 grams
Radix Rehmanniae 15 gram Radix Glycyrrhizaes 6 gram grams Radix Ophiopogonis 10
Caulis Akebiae 6 gram Folium Bambusaes 5 gram Rhizoma Imperataes 30 grams
Rhizoma Phragmitis 30 gram Fructus Ligustri Lucidi 10 gram Cortex Lycii 10 grams
The preparation method of medicine of the present invention is as follows
One, gets the raw materials ready
1, Rhizoma Alismatis: choose decontamination, big or small stepping is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section is cut dried;
2, Rhizoma Coptidis: choose decontamination, clean silt particle, run through, section is dried in the shade;
3, Plumula Nelumbinis: get crude drug, remove impurity;
4, Fructus Gardeniae: sieve dedust bits, choose decontamination, pulverize and sieve or cut off two ends;
5, Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
6, Radix Scutellariae: choose decontamination, remove residual stem, soak into or put to soak slightly in the boiled water and pull out with cold water, section is dried;
7, Radix Rehmanniae: get crude drug, remove impurity, clean, profit is cut sheet slightly, drying, and sieve removes chip;
8, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water when saturating to eighty per cant, pull out, run through section, airing;
9, Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, take out the heart after running through, clean again and dry;
10, Caulis Akebiae: water soaks slightly, and moistening is to saturating, and section is dried;
11, Folium Bambusae: choose clean impurity, except destemming leaf, dry;
12, Rhizoma Imperatae: choose clean impurity, clean, little profit, cutting is dried, the clean chip of winnowing with a dustpan;
13, Rhizoma Phragmitis: choose decontamination and root, cutting is dried;
14, Fructus Ligustri Lucidi: choose decontamination, clean, dry;
15, Cortex Lycii: choose decontamination and core, slightly wash, cutting is dried.
Two, preparation
1, Rhizoma Alismatis, Rhizoma Coptidis, Plumula Nelumbinis, Fructus Gardeniae, Poria, Radix Scutellariae, Radix Rehmanniae, Radix Glycyrrhizae, Radix Ophiopogonis, Caulis Akebiae, Folium Bambusae, Rhizoma Imperatae, Rhizoma Phragmitis, Fructus Ligustri Lucidi, the Cortex Lycii with described weight adds 1000 ml waters, intense fire decocted boiling after 10 minutes, decoct the milliliter to 200-300 with slow fire, get its decoction liquor, be 1 dose of medicinal liquid.
Medicine of the present invention has and rushes down accumulation of heat in the heart and spleen clearly, and the effect of benefiting vital QI and blood is used for recurrent oral ulceration, good effect, cure rate height.
The specific embodiment
Below further sets forth the beneficial effect of medicine of the present invention by testing example, these are tested the routine animal toxicity test of medicine of the present invention and the clinical observation on the therapeutic effect of having comprised and test.
The animal toxicity test of [test example 1] medicine of the present invention
Get 40 of new zealand rabbits, the male and female dual-purpose, body weight 2.0-2.5kg divides two groups, and 20 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 40ml/kg, and normal amount is 20ml/kg, and administering mode is the administration by gavage administration, and every day, secondary serve on 7 days, observes administration reaction every day, and the result shows that two groups of rabbit activities, diet are normal, and medicine does not have bad toxic and side effects.
The clinical observation of [test example 2] Drug therapy recurrent oral ulceration of the present invention
1, physical data
Accept out-patient's 380 examples for medical treatment.
2, diagnostic criteria
Recurrent oral ulceration is pimple earlier, forms vesicle then, and ulceration becomes aphtha in a short time.Ulcer surface is smooth, is little yellow or band Lycoperdon polymorphum Vitt, and is obviously congested on every side, has spontaneity to burn sample pain.
3, Therapeutic Method
Select above-mentioned medicament for use, take to the patient, morning every day, evening respectively obey 1 time, and each 1 dose, (medicine) being taken before meal usefulness, 5 days is a course for the treatment of, takes two courses for the treatment of continuously.
4, efficacy assessment standard
Produce effects: treatment back clinical symptom disappearance, oral cavity recover normal, do not have recurrence after following up a case by regular visits to half a year;
Take a turn for the better: clinical symptoms is obviously improved, and progressively recover in the oral cavity;
Invalid: clinical partial symptoms does not disappear or does not have change, does not reach improvement standard person.
5, therapeutic outcome
In above-mentioned treatment, with Drug therapy recurrent oral ulceration patient 380 examples of the present invention, produce effects 365 examples as a result, obvious effective rate is 96.06%, 15 examples that take a turn for the better, improvement rate is 3.95%, total effective rate is 100%.

Claims (3)

1. medicine for the treatment of recurrent oral ulceration, it is characterized in that: it is to be made by the crude drug in the following weight scope:
Rhizoma Alismatis 5-15 gram Rhizoma Coptidis 2-15 gram Plumula Nelumbinis 3-10 gram
Fructus Gardeniae 8-20 gram Poria 3-14 gram Radix Scutellariae 5-12 gram
Radix Rehmanniae 6-18 gram Radix Glycyrrhizae 3-12 gram 6-12 Radix Ophiopogonis gram
Caulis Akebiae 3-12 gram Folium Bambusae 2-12 gram Rhizoma Imperatae 20-40 gram
Rhizoma Phragmitis 20-45 gram Fructus Ligustri Lucidi 5-15 gram Cortex Lycii 5-12 gram;
The preparation method step is as follows:
(1) gets the raw materials ready
(1) Rhizoma Alismatis: choose decontamination, big or small stepping is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section is cut dried;
(2) Rhizoma Coptidis: choose decontamination, clean silt particle, run through, section is dried in the shade;
(3) Plumula Nelumbinis: get crude drug, remove impurity;
(4) Fructus Gardeniae: sieve dedust bits, choose decontamination, pulverize and sieve or cut off two ends;
(5) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
(6) Radix Scutellariae: choose decontamination, remove residual stem, soak into or put to soak slightly in the boiled water and pull out with cold water, section is dried;
(7) Radix Rehmanniae: get crude drug, remove impurity, clean, profit is cut sheet slightly, drying, and sieve removes chip;
(8) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water when saturating to eighty per cant, pull out, run through section, airing;
(9) Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, take out the heart after running through, clean again and dry;
(10) Caulis Akebiae: water soaks slightly, and moistening is to saturating, and section is dried;
(11) Folium Bambusae: choose clean impurity, except destemming leaf, dry;
(12) Rhizoma Imperatae: choose clean impurity, clean, little profit, cutting is dried, the clean chip of winnowing with a dustpan;
(13) Rhizoma Phragmitis: choose decontamination and root, cutting is dried;
(14) Fructus Ligustri Lucidi: choose decontamination, clean, dry;
(15) Cortex Lycii: choose decontamination and core, slightly wash, cutting is dried;
(2) preparation
Rhizoma Alismatis, Rhizoma Coptidis, Plumula Nelumbinis, Fructus Gardeniae, Poria, Radix Scutellariae, Radix Rehmanniae, Radix Glycyrrhizae, Radix Ophiopogonis, Caulis Akebiae, Folium Bambusae, Rhizoma Imperatae, Rhizoma Phragmitis, Fructus Ligustri Lucidi, the Cortex Lycii of described weight are added 1000 ml waters, intense fire decocted boiling after 10 minutes, decoct the milliliter to 200-300 with slow fire, get its decoction liquor, be 1 dose of medicinal liquid.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Rhizoma Alismatis 10 gram Rhizoma Coptidis 6 gram Plumula Nelumbiniss 5 grams
Fructus Gardeniae 10 gram Poria 10 gram Radix Scutellariaes 10 grams
Radix Rehmanniae 15 gram Radix Glycyrrhizaes 6 gram grams Radix Ophiopogonis 10
Caulis Akebiae 6 gram Folium Bambusaes 5 gram Rhizoma Imperataes 30 grams
Rhizoma Phragmitis 30 gram Fructus Ligustri Lucidi 10 gram Cortex Lycii 10 grams;
The preparation method step is as follows:
(1) gets the raw materials ready
(1) Rhizoma Alismatis: choose decontamination, big or small stepping is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section is cut dried;
(2) Rhizoma Coptidis: choose decontamination, clean silt particle, run through, section is dried in the shade;
(3) Plumula Nelumbinis: get crude drug, remove impurity;
(4) Fructus Gardeniae: sieve dedust bits, choose decontamination, pulverize and sieve or cut off two ends;
(5) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
(6) Radix Scutellariae: choose decontamination, remove residual stem, soak into or put to soak slightly in the boiled water and pull out with cold water, section is dried;
(7) Radix Rehmanniae: get crude drug, remove impurity, clean, profit is cut sheet slightly, drying, and sieve removes chip;
(8) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water when saturating to eighty per cant, pull out, run through section, airing;
(9) Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, take out the heart after running through, clean again and dry;
(10) Caulis Akebiae: water soaks slightly, and moistening is to saturating, and section is dried;
(11) Folium Bambusae: choose clean impurity, except destemming leaf, dry;
(12) Rhizoma Imperatae: choose clean impurity, clean, little profit, cutting is dried, the clean chip of winnowing with a dustpan;
(13) Rhizoma Phragmitis: choose decontamination and root, cutting is dried;
(14) Fructus Ligustri Lucidi: choose decontamination, clean, dry;
(15) Cortex Lycii: choose decontamination and core, slightly wash, cutting is dried;
(2) preparation
Rhizoma Alismatis, Rhizoma Coptidis, Plumula Nelumbinis, Fructus Gardeniae, Poria, Radix Scutellariae, Radix Rehmanniae, Radix Glycyrrhizae, Radix Ophiopogonis, Caulis Akebiae, Folium Bambusae, Rhizoma Imperatae, Rhizoma Phragmitis, Fructus Ligustri Lucidi, the Cortex Lycii of described weight are added 1000 ml waters, intense fire decocted boiling after 10 minutes, decoct the milliliter to 200-300 with slow fire, get its decoction liquor, be 1 dose of medicinal liquid.
3. according to the preparation method of claim 1 or 2 described medicines, it is characterized in that: it comprises the following steps:
(1) gets the raw materials ready
(1) Rhizoma Alismatis: choose decontamination, big or small stepping is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section is cut dried;
(2) Rhizoma Coptidis: choose decontamination, clean silt particle, run through, section is dried in the shade;
(3) Plumula Nelumbinis: get crude drug, remove impurity;
(4) Fructus Gardeniae: sieve dedust bits, choose decontamination, pulverize and sieve or cut off two ends;
(5) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
(6) Radix Scutellariae: choose decontamination, remove residual stem, soak into or put to soak slightly in the boiled water and pull out with cold water, section is dried;
(7) Radix Rehmanniae: get crude drug, remove impurity, clean, profit is cut sheet slightly, drying, and sieve removes chip;
(8) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water when saturating to eighty per cant, pull out, run through section, airing;
(9) Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, take out the heart after running through, clean again and dry;
(10) Caulis Akebiae: water soaks slightly, and moistening is to saturating, and section is dried;
(11) Folium Bambusae: choose clean impurity, except destemming leaf, dry;
(12) Rhizoma Imperatae: choose clean impurity, clean, little profit, cutting is dried, the clean chip of winnowing with a dustpan;
(13) Rhizoma Phragmitis: choose decontamination and root, cutting is dried;
(14) Fructus Ligustri Lucidi: choose decontamination, clean, dry;
(15) Cortex Lycii: choose decontamination and core, slightly wash, cutting is dried;
(2) preparation
Rhizoma Alismatis, Rhizoma Coptidis, Plumula Nelumbinis, Fructus Gardeniae, Poria, Radix Scutellariae, Radix Rehmanniae, Radix Glycyrrhizae, Radix Ophiopogonis, Caulis Akebiae, Folium Bambusae, Rhizoma Imperatae, Rhizoma Phragmitis, Fructus Ligustri Lucidi, the Cortex Lycii of described weight are added 1000 ml waters, intense fire decocted boiling after 10 minutes, decoct the milliliter to 200-300 with slow fire, get its decoction liquor, be 1 dose of medicinal liquid.
CN 201210297173 2012-08-21 2012-08-21 Medicine for treating recurrent oral ulcer and preparation method thereof Expired - Fee Related CN102772693B (en)

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CN103768357B (en) * 2014-02-24 2016-06-08 南京中医药大学 A kind of Traditional Chinese medicine compound composition with treatment recurrent aphtha
CN103908617B (en) * 2014-03-21 2016-08-17 青岛市口腔医院 A kind of medicinal liquid treating recurrent oral ulceration
CN105395831A (en) * 2015-12-10 2016-03-16 杨献美 A medicine composition for treating oral inflammation

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现代中西医结合杂志&gt *
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