CN103908617B - A kind of medicinal liquid treating recurrent oral ulceration - Google Patents
A kind of medicinal liquid treating recurrent oral ulceration Download PDFInfo
- Publication number
- CN103908617B CN103908617B CN201410108187.7A CN201410108187A CN103908617B CN 103908617 B CN103908617 B CN 103908617B CN 201410108187 A CN201410108187 A CN 201410108187A CN 103908617 B CN103908617 B CN 103908617B
- Authority
- CN
- China
- Prior art keywords
- medicinal liquid
- parts
- oral ulceration
- recurrent oral
- raw material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 21
- 230000000306 recurrent Effects 0.000 title claims abstract description 20
- 206010028034 Mouth ulceration Diseases 0.000 title claims abstract description 18
- 210000000582 Semen Anatomy 0.000 claims abstract description 13
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims abstract description 13
- 240000007582 Corylus avellana Species 0.000 claims abstract description 12
- 235000007466 Corylus avellana Nutrition 0.000 claims abstract description 12
- 235000005822 corn Nutrition 0.000 claims abstract description 12
- 235000005824 corn Nutrition 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 241000209149 Zea Species 0.000 claims abstract 3
- 239000003814 drug Substances 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 206010068760 Ulcers Diseases 0.000 abstract description 7
- 231100000397 ulcer Toxicity 0.000 abstract description 7
- 230000035876 healing Effects 0.000 abstract description 2
- 240000008042 Zea mays Species 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 230000002335 preservative Effects 0.000 description 8
- 239000003755 preservative agent Substances 0.000 description 8
- GYCKQBWUSACYIF-UHFFFAOYSA-N Ethyl salicylate Chemical compound CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 description 7
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 7
- 238000009835 boiling Methods 0.000 description 6
- 239000000706 filtrate Substances 0.000 description 6
- 238000004108 freeze drying Methods 0.000 description 6
- 239000008187 granular material Substances 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000002791 soaking Methods 0.000 description 4
- 208000002399 Aphthous Stomatitis Diseases 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 2
- 208000007117 Oral Ulcer Diseases 0.000 description 2
- 229940088594 Vitamin Drugs 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 229930003231 vitamins Natural products 0.000 description 2
- 240000000218 Cannabis sativa Species 0.000 description 1
- 208000002573 Connective Tissue Disease Diseases 0.000 description 1
- 241000735527 Eupatorium Species 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 241000607292 Maguireothamnus speciosus Species 0.000 description 1
- 210000002200 Mouth Mucosa Anatomy 0.000 description 1
- 240000008114 Panicum miliaceum Species 0.000 description 1
- 240000005158 Phaseolus vulgaris Species 0.000 description 1
- 240000005827 Phyllostachys nigra Species 0.000 description 1
- 235000010717 Phyllostachys nigra Nutrition 0.000 description 1
- 241000209504 Poaceae Species 0.000 description 1
- 240000006394 Sorghum bicolor Species 0.000 description 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
- 208000009226 Sutton disease 2 Diseases 0.000 description 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 1
- 241000234299 Zingiberaceae Species 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 235000006442 blackseeded proso millet Nutrition 0.000 description 1
- 235000006443 broomcorn panic Nutrition 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 235000006419 common millet Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003203 everyday Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000001861 immunosuppresant Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 235000009973 maize Nutrition 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000001225 therapeutic Effects 0.000 description 1
Abstract
The invention discloses a kind of medicinal liquid treating recurrent oral ulceration, this medicinal liquid is prepared from by raw material and excipient, by weight, described raw material includes corn cob 60 85 parts, 42 60 parts of Semen phaseoli radiati, Fructus Gardeniae 9 16 parts, Fructus Alpiniae Oxyphyllae 8 13 parts, 20 35 parts of Folium Bambusae.Evident in efficacy to recurrent oral ulceration of the medicinal liquid that the present invention relates to, can not only alleviate rapidly engorgement pain, accelerates ulcer healing, and can effective Control in recurring.
Description
Technical field
The invention belongs to technical field of Chinese medicine, in particular to a kind of external used medicine treating oral ulcer,
Particularly relate to a kind of medicinal liquid treating recurrent oral ulceration.
Background technology
Recurrent oral ulceration (recurrentoralulcer, ROU) is also known as recurrent aphtha (recurrent
Aphthousulcer, RAU), it is department of stomatology common disease.Patient due to oral mucosa repeatability ulcer damage,
Pain, it is difficult to recovery from illness, its concrete pathogenesis is the most not clear, may be relevant to the disorder of immune mechanism of body, sick
Because complexity is various, and throughout the year, no matter men and women, no matter the age all can fall ill, carry to the quality of life of people
Carry out tremendous influence.The most clinical remedy measures the most perfect for this disease, is confined to symptomatic treatment more.
Traditional treatment compound eupatorium syrup adds hormone therapy, and its curative effect is undesirable, and relapse rate is high.
Summary of the invention
In view of the deficiencies in the prior art, it is an object of the invention to by secret recipe handed down in the family is carried out lot of experiments research
And improvement, thus provide a kind of medicinal liquid effecting a radical cure recurrent oral ulceration.
The object of the present invention is achieved like this:
A kind of medicinal liquid treating recurrent oral ulceration, is prepared from by raw material and excipient, by weight,
Described raw material includes: corn cob 60-85 part, Semen phaseoli radiati 42-60 part, Fructus Gardeniae 9-16 part, Fructus Alpiniae Oxyphyllae 8-13
Part, Folium Bambusae 20-35 part.
Preferably, treat as mentioned above the medicinal liquid of recurrent oral ulceration, its by weight, described raw material
By corn cob 68-76 part, Semen phaseoli radiati 48-53 part, Fructus Gardeniae 11-13 part, Fructus Alpiniae Oxyphyllae 9-11 part and Folium Bambusae 25-29
Part composition.
In a most preferred embodiment of the present invention, treat the medicinal liquid of recurrent oral ulceration as mentioned above,
Its by weight, described raw material is by corn cob 72 parts, 50 parts of Semen phaseoli radiati, Fructus Gardeniae 12 parts, Fructus Alpiniae Oxyphyllae 10
Part and 27 parts of Folium Bambusae composition.
It is further preferred that treat the medicinal liquid of recurrent oral ulceration as mentioned above, excipient therein includes sweet
Oil and preservative, described preservative is preferably ethyl hydroxybenzoate.
The preparation method of the oral solutions that the present invention relates to comprises the steps: to weigh corn cob 60-85 part, green
Bean 42-60 part, Fructus Gardeniae 9-16 part, Fructus Alpiniae Oxyphyllae 8-13 part and Folium Bambusae 20-35 part, clean roguing, dry,
Be ground into granule, with bundle it, put in people's container, add 15-18 times of water, decoct after soaking 30 minutes to
Boiling, continues 25-40 minute, filters to get filtrate, be concentrated into paste, lyophilization evacuation, obtain extraction
Thing, standby；Weigh extract, add 25-35%(v/v in ratio that mass volume ratio is 1:2-4) sweet
Oil solution, and add appropriate preservative ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30-60min.
It should be noted that raw material of the present invention has following source: corn cob selects grass family draft
Excellent core after plant jade sorghum broomcorn millet white maize rod threshing.The seed of leguminous plant Semen phaseoli radiati selected by Semen phaseoli radiati.Fructus Gardeniae selects
Dry mature fruit with Maguireothamnus speciosus Fructus Gardeniae GardeniajasminoidesEllis.Fructus Alpiniae Oxyphyllae selects Zingiberaceae
The mature fruit of plant Fructus Alpiniae Oxyphyllae.Folium Bambusae selects the dried leaves of grass phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle.
By experimental results demonstrate, the stable curative effect of the liquid medicine applying recurrent oral ulceration of the present invention, relapse rate
Low, substantially have no side effect.Therefore, present invention also offers a kind of new use of product, it may be assumed that above-mentioned medicinal liquid
Application in the external used medicine of preparation treatment recurrent oral ulceration.Preferably described external used medicine be cream,
Spray.
Compared with prior art, evident in efficacy to recurrent oral ulceration of the medicinal liquid that the present invention relates to, can not only
Alleviate rapidly engorgement pain, accelerate ulcer healing, and can effective Control in recurring, after treating, follow up a case by regular visits to half a year not
Recur again.
Detailed description of the invention
The following is the specific embodiment of the present invention, technical scheme is done to be described further, but this
The protection domain of invention is not limited to these embodiments.Every change without departing substantially from present inventive concept or equivalent substitute
Within being included in protection scope of the present invention.
Embodiment 1
Weigh corn cob 720g, Semen phaseoli radiati 500g, Fructus Gardeniae 120g, Fructus Alpiniae Oxyphyllae 100g and Folium Bambusae 270g, clean
Roguing, dries, and is ground into granule, with bundle it, put in people's container, add 16 times of water, soak 30 minutes
Rear decoction, to boiling, continues 40 minutes, filters to get filtrate, be concentrated into paste, lyophilization evacuation,
Obtain extract, standby；Weigh extract, add 33%(v/v in the ratio that mass volume ratio is 1:3)
Glycerine water solution, and add appropriate preservative ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30min.
Embodiment 2
Weigh corn cob 800g, Semen phaseoli radiati 420g, Fructus Gardeniae 90g, Fructus Alpiniae Oxyphyllae 100g and Folium Bambusae 200g, clean and go
Miscellaneous, dry, be ground into granule, with bundle it, put in people's container, add 16 times of water, after soaking 30 minutes
Decoct to boiling, continue 30 minutes, filter to get filtrate, be concentrated into paste, lyophilization evacuation, obtain
Extract, standby；Weigh extract, add 25%(v/v in ratio that mass volume ratio is 1:2) sweet
Oil solution, and add appropriate preservative ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30min.
Embodiment 3
Weigh corn cob 850g, Semen phaseoli radiati 580g, Fructus Gardeniae 150g, Fructus Alpiniae Oxyphyllae 130g and Folium Bambusae 250g, clean
Roguing, dries, and is ground into granule, with bundle it, put in people's container, add 18 times of water, soak 30 minutes
Rear decoction, to boiling, continues 40 minutes, filters to get filtrate, be concentrated into paste, lyophilization evacuation,
Obtain extract, standby；Weigh extract, add 33%(v/v in the ratio that mass volume ratio is 1:4)
Glycerine water solution, and add appropriate preservative ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30min.
Embodiment 4
Weigh corn cob 600g, Semen phaseoli radiati 550g, Fructus Gardeniae 120g, Fructus Alpiniae Oxyphyllae 80g and Folium Bambusae 350g, clean and go
Miscellaneous, dry, be ground into granule, with bundle it, put in people's container, add 16 times of water, after soaking 30 minutes
Decoct to boiling, continue 40 minutes, filter to get filtrate, be concentrated into paste, lyophilization evacuation, obtain
Extract, standby；Weigh extract, add 33%(v/v in ratio that mass volume ratio is 1:3) sweet
Oil solution, and add appropriate preservative ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30min.
Comparative example
Weigh Semen phaseoli radiati 500g, Fructus Gardeniae 120g and Folium Bambusae 270g, clean roguing, dry, be ground into granule, use
Bundle it, put in people's container, add 16 times of water, after soaking 30 minutes decoct to boiling, continue 40 minutes,
Filter to get filtrate, be concentrated into paste, lyophilization evacuation, obtain extract, standby；Weigh extract,
Add 33%(v/v in ratio that mass volume ratio is 1:3) glycerine water solution, and add appropriate preservative
Ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30min.
Clinical practice example
Get rid of immunologic hypofunction, patients with connective tissue diseases, use glucocorticoid and immunosuppressant person and have
Other, locally or systemically after systemic disease person, meet 58 example patients of recurrent oral ulceration diagnostic criteria,
The maleest 26 examples, female 31 example, age 23～57 years old.All patients are randomly divided into test A group (29 example)
With test B group (29 example).Two groups are compared at the aspect such as sex, age and there was no significant difference.
Test A group patient uses dry cotton swab to pick appropriate getting ready on the basis of oral vitamin B5mg/d
Medicinal liquid (prescription and technique according to above-described embodiment 1 are prepared from), be applied to oral ulcer position lightly.
Remain silent after coating, can not gargle immediately, drink water and take food.Medication every day 3 times, one week is a course for the treatment of.
Test B group patient uses dry cotton swab to pick appropriate getting ready on the basis of oral vitamin B5mg/d
Medicinal liquid (prescription and technique according to above-mentioned comparative example are prepared from), within one week, be a course for the treatment of.
After two groups of patients all treat a course for the treatment of, carry out therapeutic outcome statistics by following curative effect judging standard:
Effective: in treating latter 5 days, ulcer heals substantially, and engorgement pain disappears substantially；Effective: ulcer in 5 days
Area is obviously reduced, and engorgement pain substantially alleviates；Invalid: after 5 days, ulcer area, hyperemia, pain are without substantially
Improve.
Two groups of comparitive study are shown in Table 1.By table 1 it can be seen that use the medicinal liquid of the present invention for recurrent mouth
The treatment of chamber ulcer, the liquid medicine applying comparing comparative example has more preferable curative effect.It addition, test A group
Follow-up of patients half a year, no case was recurrence.
1 liang of table group comparitive study
Claims (4)
1. the medicinal liquid treating recurrent oral ulceration, it is characterised in that: it is prepared from by raw material and excipient, presses
Weight portion meter, described raw material is by corn cob 68-76 part, Semen phaseoli radiati 48-53 part, Fructus Gardeniae 11-13 part, Fructus Alpiniae Oxyphyllae 9-11
Part and Folium Bambusae 25-29 part form.
Treat the medicinal liquid of recurrent oral ulceration the most according to claim 1, it is characterised in that: by weight,
Described raw material is made up of corn cob 72 parts, 50 parts of Semen phaseoli radiati, Fructus Gardeniae 12 parts, Fructus Alpiniae Oxyphyllae 10 parts and 27 parts of Folium Bambusae.
3. the application in the external used medicine of preparation treatment recurrent oral ulceration of the medicinal liquid described in claim 1 or 2.
Application the most according to claim 3, it is characterised in that: described external used medicine is cream, spray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410108187.7A CN103908617B (en) | 2014-03-21 | 2014-03-21 | A kind of medicinal liquid treating recurrent oral ulceration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410108187.7A CN103908617B (en) | 2014-03-21 | 2014-03-21 | A kind of medicinal liquid treating recurrent oral ulceration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103908617A CN103908617A (en) | 2014-07-09 |
| CN103908617B true CN103908617B (en) | 2016-08-17 |
Family
ID=51034821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410108187.7A Expired - Fee Related CN103908617B (en) | 2014-03-21 | 2014-03-21 | A kind of medicinal liquid treating recurrent oral ulceration |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103908617B (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102038740A (en) * | 2009-10-09 | 2011-05-04 | 吴海洋 | Formula for treating aphtha |
| CN102671039A (en) * | 2012-04-04 | 2012-09-19 | 张敏丽 | Chinese medicinal composition for treating aphtha of mouth and tongue |
| CN102772693B (en) * | 2012-08-21 | 2013-09-11 | 孙凤梅 | Medicine for treating recurrent oral ulcer and preparation method thereof |
-
2014
- 2014-03-21 CN CN201410108187.7A patent/CN103908617B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN103908617A (en) | 2014-07-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20110318438A1 (en) | Pharmacologically effective composition of herbs for treatment on symptoms of influenza and colds | |
| CN104857290A (en) | Traditional Chinese medicine disinfection ointment for treating scalds and burns and preparation method thereof | |
| CN104258455B (en) | A kind of medical bio antiseptic dressing and preparation method thereof | |
| CN102247562A (en) | Chinese medicinal formula for treating acne | |
| CN104800597A (en) | Traditional Chinese medicine composition for treating sphagitis | |
| CN102743663A (en) | Chinese medicinal preparation for treating urinary infection and preparation method thereof | |
| CN105851592A (en) | Sow mastitis feed additive with slow-release effect and preparation method | |
| CN113616721A (en) | Pharmaceutical composition for treating oral ulcer and preparation method and application thereof | |
| CN104258236A (en) | Traditional Chinese medicine composition for nursing vaginas of women in puerperium | |
| CN104274579A (en) | Traditional Chinese medicine oil for preventing and controlling mosquito bite and preparation method of traditional Chinese medicine oil | |
| CN103908617B (en) | A kind of medicinal liquid treating recurrent oral ulceration | |
| CN101810781B (en) | Oral spray agent for treating oral ulcers and preparation method thereof | |
| CN107260844A (en) | A kind of bacteriostasis spray | |
| CN104161871B (en) | Tinea capitis (tinea alba) external is rubbed with the hands and is coated with medicated wine and preparation method thereof | |
| CN105194443A (en) | Traditional Chinese medicine composition for treating infantile eczema and preparation method of composition | |
| CN103127465B (en) | Chinese medicament for treating mammary gland hyperplasia | |
| CN105194306A (en) | Papaya lozenges for treating oral ulcer and preparation method for papaya lozenges | |
| CN104116858A (en) | A traditional Chinese medicine for treating pseudomembranous enteritis | |
| CN104208282B (en) | A kind of Chinese medicine preparation for being used to nurse one's health the damage miscellaneous disease of capacitive skin | |
| CN103961554A (en) | Medicine for treating acute lingual tonsilitis and preparation method thereof | |
| CN104587035B (en) | Medicine composition for treating oral ulcer and preparation method for medicine composition | |
| WO2018176642A1 (en) | Chinese medicine for treating skin inflammation | |
| CN102671024B (en) | Ointment for treating oral ulcer and preparation method thereof | |
| CN106389280A (en) | Special moisturizing spray used for acne skins, and production method thereof | |
| CN106540051B (en) | Treat Chinese medicine composition, pulvis and the paste and preparation method thereof of rhinitis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160817 Termination date: 20170321 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |