CN103908617B - A kind of medicinal liquid treating recurrent oral ulceration - Google Patents

A kind of medicinal liquid treating recurrent oral ulceration Download PDF

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Publication number
CN103908617B
CN103908617B CN201410108187.7A CN201410108187A CN103908617B CN 103908617 B CN103908617 B CN 103908617B CN 201410108187 A CN201410108187 A CN 201410108187A CN 103908617 B CN103908617 B CN 103908617B
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China
Prior art keywords
medicinal liquid
parts
oral ulceration
recurrent oral
raw material
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Expired - Fee Related
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CN201410108187.7A
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Chinese (zh)
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CN103908617A (en
Inventor
朱鲲
王娟
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Qingdao Stomatological Hospital
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Qingdao Stomatological Hospital
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Abstract

The invention discloses a kind of medicinal liquid treating recurrent oral ulceration, this medicinal liquid is prepared from by raw material and excipient, by weight, described raw material includes corn cob 60 85 parts, 42 60 parts of Semen phaseoli radiati, Fructus Gardeniae 9 16 parts, Fructus Alpiniae Oxyphyllae 8 13 parts, 20 35 parts of Folium Bambusae.Evident in efficacy to recurrent oral ulceration of the medicinal liquid that the present invention relates to, can not only alleviate rapidly engorgement pain, accelerates ulcer healing, and can effective Control in recurring.

Description

A kind of medicinal liquid treating recurrent oral ulceration
Technical field
The invention belongs to technical field of Chinese medicine, in particular to a kind of external used medicine treating oral ulcer, Particularly relate to a kind of medicinal liquid treating recurrent oral ulceration.
Background technology
Recurrent oral ulceration (recurrentoralulcer, ROU) is also known as recurrent aphtha (recurrent Aphthousulcer, RAU), it is department of stomatology common disease.Patient due to oral mucosa repeatability ulcer damage, Pain, it is difficult to recovery from illness, its concrete pathogenesis is the most not clear, may be relevant to the disorder of immune mechanism of body, sick Because complexity is various, and throughout the year, no matter men and women, no matter the age all can fall ill, carry to the quality of life of people Carry out tremendous influence.The most clinical remedy measures the most perfect for this disease, is confined to symptomatic treatment more. Traditional treatment compound eupatorium syrup adds hormone therapy, and its curative effect is undesirable, and relapse rate is high.
Summary of the invention
In view of the deficiencies in the prior art, it is an object of the invention to by secret recipe handed down in the family is carried out lot of experiments research And improvement, thus provide a kind of medicinal liquid effecting a radical cure recurrent oral ulceration.
The object of the present invention is achieved like this:
A kind of medicinal liquid treating recurrent oral ulceration, is prepared from by raw material and excipient, by weight, Described raw material includes: corn cob 60-85 part, Semen phaseoli radiati 42-60 part, Fructus Gardeniae 9-16 part, Fructus Alpiniae Oxyphyllae 8-13 Part, Folium Bambusae 20-35 part.
Preferably, treat as mentioned above the medicinal liquid of recurrent oral ulceration, its by weight, described raw material By corn cob 68-76 part, Semen phaseoli radiati 48-53 part, Fructus Gardeniae 11-13 part, Fructus Alpiniae Oxyphyllae 9-11 part and Folium Bambusae 25-29 Part composition.
In a most preferred embodiment of the present invention, treat the medicinal liquid of recurrent oral ulceration as mentioned above, Its by weight, described raw material is by corn cob 72 parts, 50 parts of Semen phaseoli radiati, Fructus Gardeniae 12 parts, Fructus Alpiniae Oxyphyllae 10 Part and 27 parts of Folium Bambusae composition.
It is further preferred that treat the medicinal liquid of recurrent oral ulceration as mentioned above, excipient therein includes sweet Oil and preservative, described preservative is preferably ethyl hydroxybenzoate.
The preparation method of the oral solutions that the present invention relates to comprises the steps: to weigh corn cob 60-85 part, green Bean 42-60 part, Fructus Gardeniae 9-16 part, Fructus Alpiniae Oxyphyllae 8-13 part and Folium Bambusae 20-35 part, clean roguing, dry, Be ground into granule, with bundle it, put in people's container, add 15-18 times of water, decoct after soaking 30 minutes to Boiling, continues 25-40 minute, filters to get filtrate, be concentrated into paste, lyophilization evacuation, obtain extraction Thing, standby;Weigh extract, add 25-35%(v/v in ratio that mass volume ratio is 1:2-4) sweet Oil solution, and add appropriate preservative ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30-60min.
It should be noted that raw material of the present invention has following source: corn cob selects grass family draft Excellent core after plant jade sorghum broomcorn millet white maize rod threshing.The seed of leguminous plant Semen phaseoli radiati selected by Semen phaseoli radiati.Fructus Gardeniae selects Dry mature fruit with Maguireothamnus speciosus Fructus Gardeniae GardeniajasminoidesEllis.Fructus Alpiniae Oxyphyllae selects Zingiberaceae The mature fruit of plant Fructus Alpiniae Oxyphyllae.Folium Bambusae selects the dried leaves of grass phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle.
By experimental results demonstrate, the stable curative effect of the liquid medicine applying recurrent oral ulceration of the present invention, relapse rate Low, substantially have no side effect.Therefore, present invention also offers a kind of new use of product, it may be assumed that above-mentioned medicinal liquid Application in the external used medicine of preparation treatment recurrent oral ulceration.Preferably described external used medicine be cream, Spray.
Compared with prior art, evident in efficacy to recurrent oral ulceration of the medicinal liquid that the present invention relates to, can not only Alleviate rapidly engorgement pain, accelerate ulcer healing, and can effective Control in recurring, after treating, follow up a case by regular visits to half a year not Recur again.
Detailed description of the invention
The following is the specific embodiment of the present invention, technical scheme is done to be described further, but this The protection domain of invention is not limited to these embodiments.Every change without departing substantially from present inventive concept or equivalent substitute Within being included in protection scope of the present invention.
Embodiment 1
Weigh corn cob 720g, Semen phaseoli radiati 500g, Fructus Gardeniae 120g, Fructus Alpiniae Oxyphyllae 100g and Folium Bambusae 270g, clean Roguing, dries, and is ground into granule, with bundle it, put in people's container, add 16 times of water, soak 30 minutes Rear decoction, to boiling, continues 40 minutes, filters to get filtrate, be concentrated into paste, lyophilization evacuation, Obtain extract, standby;Weigh extract, add 33%(v/v in the ratio that mass volume ratio is 1:3) Glycerine water solution, and add appropriate preservative ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30min.
Embodiment 2
Weigh corn cob 800g, Semen phaseoli radiati 420g, Fructus Gardeniae 90g, Fructus Alpiniae Oxyphyllae 100g and Folium Bambusae 200g, clean and go Miscellaneous, dry, be ground into granule, with bundle it, put in people's container, add 16 times of water, after soaking 30 minutes Decoct to boiling, continue 30 minutes, filter to get filtrate, be concentrated into paste, lyophilization evacuation, obtain Extract, standby;Weigh extract, add 25%(v/v in ratio that mass volume ratio is 1:2) sweet Oil solution, and add appropriate preservative ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30min.
Embodiment 3
Weigh corn cob 850g, Semen phaseoli radiati 580g, Fructus Gardeniae 150g, Fructus Alpiniae Oxyphyllae 130g and Folium Bambusae 250g, clean Roguing, dries, and is ground into granule, with bundle it, put in people's container, add 18 times of water, soak 30 minutes Rear decoction, to boiling, continues 40 minutes, filters to get filtrate, be concentrated into paste, lyophilization evacuation, Obtain extract, standby;Weigh extract, add 33%(v/v in the ratio that mass volume ratio is 1:4) Glycerine water solution, and add appropriate preservative ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30min.
Embodiment 4
Weigh corn cob 600g, Semen phaseoli radiati 550g, Fructus Gardeniae 120g, Fructus Alpiniae Oxyphyllae 80g and Folium Bambusae 350g, clean and go Miscellaneous, dry, be ground into granule, with bundle it, put in people's container, add 16 times of water, after soaking 30 minutes Decoct to boiling, continue 40 minutes, filter to get filtrate, be concentrated into paste, lyophilization evacuation, obtain Extract, standby;Weigh extract, add 33%(v/v in ratio that mass volume ratio is 1:3) sweet Oil solution, and add appropriate preservative ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30min.
Comparative example
Weigh Semen phaseoli radiati 500g, Fructus Gardeniae 120g and Folium Bambusae 270g, clean roguing, dry, be ground into granule, use Bundle it, put in people's container, add 16 times of water, after soaking 30 minutes decoct to boiling, continue 40 minutes, Filter to get filtrate, be concentrated into paste, lyophilization evacuation, obtain extract, standby;Weigh extract, Add 33%(v/v in ratio that mass volume ratio is 1:3) glycerine water solution, and add appropriate preservative Ethyl hydroxybenzoate, subpackage, 115 DEG C of high temperature sterilize 30min.
Clinical practice example
Get rid of immunologic hypofunction, patients with connective tissue diseases, use glucocorticoid and immunosuppressant person and have Other, locally or systemically after systemic disease person, meet 58 example patients of recurrent oral ulceration diagnostic criteria, The maleest 26 examples, female 31 example, age 23~57 years old.All patients are randomly divided into test A group (29 example) With test B group (29 example).Two groups are compared at the aspect such as sex, age and there was no significant difference.
Test A group patient uses dry cotton swab to pick appropriate getting ready on the basis of oral vitamin B5mg/d Medicinal liquid (prescription and technique according to above-described embodiment 1 are prepared from), be applied to oral ulcer position lightly. Remain silent after coating, can not gargle immediately, drink water and take food.Medication every day 3 times, one week is a course for the treatment of.
Test B group patient uses dry cotton swab to pick appropriate getting ready on the basis of oral vitamin B5mg/d Medicinal liquid (prescription and technique according to above-mentioned comparative example are prepared from), within one week, be a course for the treatment of.
After two groups of patients all treat a course for the treatment of, carry out therapeutic outcome statistics by following curative effect judging standard:
Effective: in treating latter 5 days, ulcer heals substantially, and engorgement pain disappears substantially;Effective: ulcer in 5 days Area is obviously reduced, and engorgement pain substantially alleviates;Invalid: after 5 days, ulcer area, hyperemia, pain are without substantially Improve.
Two groups of comparitive study are shown in Table 1.By table 1 it can be seen that use the medicinal liquid of the present invention for recurrent mouth The treatment of chamber ulcer, the liquid medicine applying comparing comparative example has more preferable curative effect.It addition, test A group Follow-up of patients half a year, no case was recurrence.
1 liang of table group comparitive study

Claims (4)

1. the medicinal liquid treating recurrent oral ulceration, it is characterised in that: it is prepared from by raw material and excipient, presses Weight portion meter, described raw material is by corn cob 68-76 part, Semen phaseoli radiati 48-53 part, Fructus Gardeniae 11-13 part, Fructus Alpiniae Oxyphyllae 9-11 Part and Folium Bambusae 25-29 part form.
Treat the medicinal liquid of recurrent oral ulceration the most according to claim 1, it is characterised in that: by weight, Described raw material is made up of corn cob 72 parts, 50 parts of Semen phaseoli radiati, Fructus Gardeniae 12 parts, Fructus Alpiniae Oxyphyllae 10 parts and 27 parts of Folium Bambusae.
3. the application in the external used medicine of preparation treatment recurrent oral ulceration of the medicinal liquid described in claim 1 or 2.
Application the most according to claim 3, it is characterised in that: described external used medicine is cream, spray.
CN201410108187.7A 2014-03-21 2014-03-21 A kind of medicinal liquid treating recurrent oral ulceration Expired - Fee Related CN103908617B (en)

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Application Number Priority Date Filing Date Title
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CN103908617B true CN103908617B (en) 2016-08-17

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Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102038740A (en) * 2009-10-09 2011-05-04 吴海洋 Formula for treating aphtha
CN102671039A (en) * 2012-04-04 2012-09-19 张敏丽 Chinese medicinal composition for treating aphtha of mouth and tongue
CN102772693B (en) * 2012-08-21 2013-09-11 孙凤梅 Medicine for treating recurrent oral ulcer and preparation method thereof

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