CN116115689A - Seven-orifice rhinitis-relieving spray and preparation method thereof - Google Patents
Seven-orifice rhinitis-relieving spray and preparation method thereof Download PDFInfo
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- CN116115689A CN116115689A CN202310203071.0A CN202310203071A CN116115689A CN 116115689 A CN116115689 A CN 116115689A CN 202310203071 A CN202310203071 A CN 202310203071A CN 116115689 A CN116115689 A CN 116115689A
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- fructus
- rhinitis
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- spray
- orifice
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Abstract
The invention relates to the field of medicines, in particular to application of a seven-orifice rhinitis-relieving spray; the seven-orifice rhinitis-relieving spray comprises the following raw materials: fructus Xanthii, radix Scutellariae, radix Saposhnikoviae, flos Magnoliae, TONGGUO powder, herba Bidentis Bipinnatae, fructus Chebulae, fructus Jun Cao Zhao, stigma croci Sativi, fel Ursi powder, borneolum Syntheticum, and herba Menthae extract; the seven-orifice rhinitis-relieving spray takes biological immunotherapy as a core, and uses the treatment advantages of targeting positioning to effectively and directly treat the bear gall powder and other medicaments on the focus, rapidly penetrate through pathological tissues of the nasal cavity, repair pathological tissue cells, activate the immunocompetence of autologous cells, improve the function of a respiratory immune system, and achieve the purposes of rapidly and long-acting treatment, treatment of both symptoms and root causes and health care of the respiratory system. The seven-orifice rhinitis-relieving spray fully considers the traditional Chinese medicine theory of Chinese medicinal materials such as sex taste, channel tropism, incompatibility and the like, and has broad-spectrum antibacterial and anti-inflammatory symptomatic effects on nasal cavity diseases. Can be used for treating resuscitation, detumescence, dispelling pathogenic wind, and clearing heat. Can be used for treating acute and chronic rhinitis, sinusitis, nasal obstruction, headache, turbid nasal discharge, odor, and olfactory failure.
Description
The application is a divisional application of which the application date is 2018, 07, 12, the application number is 201810763594.X, and the invention name is 'seven-orifice rhinitis spray and a preparation method thereof'.
Technical Field
The invention relates to the field of medicines, in particular to a seven-orifice rhinitis-relieving spray and a preparation method thereof.
Background
Allergic rhinitis is one of the most common chronic diseases worldwide, and traditionally allergic rhinitis is seasonal and perennial allergic rhinitis. The former is associated with pollen, including air-pollinated pastures, trees, weeds and fungal spores, and the latter is often caused by dust mites, animal dander, etc. In recent years, the incidence of global allergic diseases is on the rise, and the medical expenditure caused by the global allergic diseases is quite remarkable, so that the global allergic diseases are getting more and more attention to society.
For a long time, rhinitis threatens the health of thousands of people, and when rhinitis occurs, symptoms such as nasal obstruction, nasal discharge, smell decline, headache, dizziness, inappetence, easy tiredness, hypomnesis, insomnia and the like seriously afflict the daily life of the people. The method for applying medicine in nasal cavity is the most common and effective method for treating rhinitis in people, and the common treatment method in the prior art is to coat medical cotton (or gauze) with medicine and plug the medicine into nostrils, but the method is very simple, if the cotton ball is too large, the whole nostrils are blocked and airtight, the medicine is too small and is easy to loosen in the nostrils, and in addition, the medicine is very inconvenient to take by hands and is not sanitary.
Disclosure of Invention
The invention aims to provide a seven-orifice rhinitis-relieving spray and a preparation method thereof, which have broad-spectrum antibacterial and anti-inflammatory symptomatic effects on nasal diseases; is used for treating resuscitation, detumescence, dispelling pathogenic wind and clearing heat.
In order to solve the technical problems, the invention adopts the following technical scheme:
the seven-orifice rhinitis-relieving spray comprises the following raw materials: fructus Xanthii, radix Scutellariae, radix Saposhnikoviae, flos Magnoliae, TONGGUO powder, herba Bidentis Bipinnatae, fructus Chebulae, fructus Jun Cao Zhao, stigma croci Sativi, fel Ursi powder, borneolum Syntheticum, and herba Menthae extract.
Further, the traditional Chinese medicine composition comprises, by weight, 50-70g of fructus xanthii, 50-70g of radix scutellariae, 30-50g of radix sileris, 30-50g of flos magnoliae, 10-30g of Tongguan powder, 10-30g of sticktight, 10-30g of myrobalan, 8-12g of fructus akebiae, 8-12g of saffron crocus, 4-8g of bear gall powder, 2-5g of borneol and 2-5g of mint extract.
Further, the traditional Chinese medicine composition comprises the following raw materials in parts by weight of 1000ml, wherein the raw materials comprise 60g of cocklebur fruit, 60g of baical skullcap root, 40g of divaricate saposhnikovia root, 40g of magnolia flower, 20g of Tongguansan, 20g of spanishneedles herb, 20g of myrobalan, 10g of fructus akebia, 10g of saffron, 6g of bear gall powder, 3g of borneol and 3g of mint extract.
Further, the content of the active ingredient ursodeoxycholic acid in the bear gall powder is 47% -53%.
The preparation method of the seven-orifice rhinitis-relieving spray comprises the following steps:
s1, parching fructus Xanthii to brown, adding nine materials of fructus Xanthii, radix Scutellariae, radix Ledebouriellae, flos Magnoliae, TONGGUAN powder, herba Bidentis Bipinnatae, fructus Chebulae, fructus Jun Caesalpiniae, stigma croci Sativi, adding 5 times of water for the first time, decocting for 4 hours, adding 2 times of water for the second time, decocting for 3 hours, mixing decoctions, and filtering for use;
s2, adding 500ml of water into bear gall powder, heating and boiling for 10 minutes to dissolve, and cooling for later use;
s3, adding ethanol into borneol and mint extracts to fully dissolve the borneol and the mint extracts, adding equal amount of water, filtering after microcrystal is separated out, and washing the microcrystal with water for many times until no alcohol smell exists; mixing the microcrystalline with the above medicinal liquid, adding water to 1000ml, filtering, and packaging.
The invention provides an application of the seven-orifice rhinitis-relieving composition in preparing nasal cavity disease spray, wherein the components of the seven-orifice rhinitis-relieving composition are as follows: fructus Xanthii, radix Scutellariae, radix Saposhnikoviae, flos Magnoliae, TONGGUO powder, herba Bidentis Bipinnatae, fructus Chebulae, fructus Jun Cao Zhao, stigma croci Sativi, fel Ursi powder, borneolum Syntheticum and herba Menthae extract.
Further, the nasal cavity diseases include: one or more of acute rhinitis, chronic rhinitis, sinusitis, nasal obstruction, headache, turbid nasal discharge odor and olfactory failure.
Compared with the prior art, the invention has at least one of the following beneficial effects:
1. the invention takes biological immunotherapy as a core, and uses the treatment advantages of targeting and positioning to effectively and directly reach focus of infection with bear gall powder and other medicaments, rapidly permeate pathological tissues of nasal cavity, repair pathological tissue cells, activate autoimmune cell immunocompetence, improve respiratory immune system function, and achieve the purposes of rapid and long-acting, treatment of both symptoms and root causes, and health care of respiratory system.
2. For the production process, the raw materials are separately treated and added according to a certain sequence, and the mixture of borneol and mint extract is fully considered and applied to form a eutectic mixture, so that the liquefaction phenomenon can occur, the melting point and the boiling point of the mixture are greatly reduced, and the uniformity of the mixture is greatly improved.
3. The invention is prepared by the compatibility of 1 animal medicine (bear gall powder) and 11 medicinal materials mainly produced in Yunnan and Datural property (fructus Xanthii, radix scutellariae, radix sileris, flos magnoliae, tongguan powder, sticktight, myrobalan, fructus kaki, saffron, borneol and mint extracts). The formula fully considers the traditional Chinese medicine theories such as the nature and taste of the traditional Chinese medicine, the meridian tropism, the compatibility tabu and the like, is a model of combining animal medicines with plant medicines, and has broad-spectrum antibacterial and anti-inflammatory symptomatic effects on nasal diseases. Can be used for treating resuscitation, detumescence, dispelling pathogenic wind, and clearing heat. Can be used for treating acute and chronic rhinitis, sinusitis, nasal obstruction, headache, turbid nasal discharge, odor, and olfactory failure. The formula of the seven-orifice rhinitis-relieving spray fully considers the traditional Chinese medicine theory of the traditional Chinese medicines such as the nature and taste, the meridian tropism, the compatibility tabu and the like, is a model of combining animal medicines with plant medicines, and has broad-spectrum antibacterial and anti-inflammatory symptomatic effects on nasal diseases. Can be used for treating resuscitation, detumescence, dispelling pathogenic wind, and clearing heat. Can be used for treating acute and chronic rhinitis, sinusitis, nasal obstruction, headache, turbid nasal discharge, odor, and olfactory failure.
Fructus Xanthii: the fruit with the total bud of the dry mature xanthium sibiricum of the Compositae plant. Its flavor is bitter, sweet, pungent and warm. It enters lung and liver meridians. Has effects of dispelling pathogenic wind and cold, relieving stuffy nose, dispelling pathogenic wind and dampness, and relieving pain. Can be used for treating common cold due to wind-cold, nasosinusitis, rheumatalgia, etc. The folk proved recipe of the national minority of the white nationality is used for treating folk medication habit of exogenous wind-cold on the nasosinusitis surface by taking fructus xanthii, flos magnoliae and radix angelicae, decocting and taking the materials.
Radix Scutellariae Baicalensis: the root of the perennial herb of Scutellaria of Labiatae is used as a medicine. It is bitter in flavor, cold in nature and nontoxic. Enter lung and large intestine meridians. Has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing toxic substances, and stopping bleeding, and can be used for treating upper respiratory infection, cough due to lung heat, jaundice due to damp-heat, carbuncle, furuncle, and sore. The traditional baikal skullcap root, green tea and powder for clearing away heat and toxic materials are used for treating cough due to lung heat, clearing lung-heat and suppressing fire, and has good effects.
Cloud windproof: mainly produced in northwest of Yunnan province, is root of Umbelliferae plants including Apium graveolens, apium pinnata and Apium graveolens of Mao Xifeng. It is pungent in flavor, slightly sweet and slightly warm in nature. It enters lung, liver and spleen meridians. Has effects of dispelling pathogenic wind, eliminating dampness, relieving pain and relieving spasm, and can be used for treating common cold, headache, rheumatalgia, tinnitus, nasal obstruction, etc. The oral administration of the yunshu-feng huo wine or the external washing of proper decoction for affected parts are used for dispelling wind and eliminating dampness, relieving pain and spasm, dispelling wind and removing dampness.
Flos Magnoliae: the main product of Yunnan is dried flower bud of Magnoliaceae plant flos Magnoliae, magnolia and Magnolia with great significance. It is pungent in flavor and warm in nature. Enter lung and stomach meridians. Has effects of dispelling pathogenic wind and cold, and relieving stuffy nose. Is mainly used for treating wind-cold type common cold, nasosinusitis and nasal obstruction. The traditional Chinese medicine for treating cerebral leakage and nasosinusitis in the minority nationality area of Yunnan province is taken with hot wine after baking new tiles into powder. It is used to treat facial cold pain and stomach qi pain (Ben Cao in Yunnan). The Yulan is produced in Dazhou, and the dried flower buds are taken, and are brewed and drunk together with tea in early spring, so that the Yulan is used for dispersing wind-cold, relieving stuffy nose and improving body immunity.
Tongguan powder: is prepared from caulis et folium Gaultheriae Yunnanensis by mixing with herba Hedyotideae plant Tongguan powder. The aliases "Tongguansan" and "Huang Muxiang". It is bitter in flavor and slightly cold in nature. It enters lung and liver meridians. Has effects of clearing away heat and toxic materials, quenching thirst, and relieving asthma. Can be used for treating pneumonia, bronchitis, pharyngolaryngitis, and rhinitis. The medicine taking habit of directly slicing and soaking water for taking is adopted in the ethnic minority area of the white ethnic group, and the medicine is used for treating upper respiratory diseases such as laryngitis, canker sore and the like, and the effect is remarkable.
Herba Bidentis Bipinnatae: annual herbaceous plants of the Compositae family are Chinese herbal medicines commonly used in China. The regions in Yunnan are commonly referred to as "adhesions" and "mucinous grass". It is bitter in taste, mild in nature and nontoxic. Enter lung, liver and large intestine meridians. Has effects of clearing heat and detoxicating, removing blood stasis and detumescence. Can be used for treating upper respiratory tract infection, tonsillitis, laryngitis, rhinitis, and skin infection. The soaking solution is used for wiping wounds and skin surface infection, has antibacterial and anti-inflammatory effects, and has strong antibacterial effect on in vitro gram-positive bacteria and staphylococcus aureus.
Myrobalan: mainly produced in Yunnan, is the dry mature fruit of Terminalia chebula (Chebulaceae) or Terminalia chebula (Terminalia chebula) and also called Terminalia chebula (Chebula) and Terminalia chebula. In the classical works of Tibetan medicine, "Jingzhu Bencao," chebula is called "Tibetan medicine king". It is bitter, sour, astringent and neutral in nature. Enter lung meridian; large intestine channel; stomach meridian. Has the effects of astringing intestines to check diarrhea, astringing lung to check cough, reducing pathogenic fire to relieve sore throat. Can be used for treating chronic diarrhea, chronic dysentery, hematochezia rectocele, lung deficiency asthma and cough, chronic cough, pharyngalgia, hoarseness, etc. The myrobalan is a traditional variety with homology of medicine and food, and is soaked in edible white spirit or squeezed juice for soaking in water in the small-name area of the Lincang in Yunnan, and is taken as a daily health-care drink for preventing and treating symptoms such as lung deficiency, asthma and cough, chronic cough, sore throat, hoarseness and the like.
Fructus kaki (radix et rhizoma Rhei, radix et rhizoma Rhei preparata): is a perennial tall herb plant of Rheum of Polygonaceae. It is bitter in flavor and cold in nature. It enters lung meridian, stomach meridian, large intestine meridian, liver meridian and spleen meridian. Has the effects of removing accumulation and stagnation; clearing damp heat; purging fire; cooling blood; removing blood stasis; detoxification efficacy. Can be used for treating constipation due to excessive heat and jaundice; gonorrhea; dysuria; conjunctival congestion; sore throat; sores of the mouth and tongue, etc.
Saffron crocus: perennial flowers of the genus crocus of the Iridaceae family are also a common spice, perennial herbs. It has special smell, slightly pungent taste and slightly bitter taste. Sweet and neutral in nature. It enters lung meridian, heart meridian and liver meridian. Has the effects of promoting blood circulation and removing blood stasis; removing blood stasis and resolving hard mass; cooling blood and detoxicating. For abdominal mass pain; traumatic injury; depression and oppression; palpitation; spot formation of warm diseases; measles, etc. The saffron is a precious object in the ethnic area of the white minority, is often taken after being purchased with the national festival of March every year, is soaked in water or soaked in wine, and is used for household preparation for activating blood, removing stasis, resolving masses, cooling blood and detoxifying.
Borneol: is prepared from stems and leaves of blumea balsamifera of Compositae or branches and leaves of Cinnamomum camphora of Lauraceae by steam distillation and recrystallization, and is a common Chinese medicinal material of the five sense organs. The powder is applied topically or mixed with the affected parts. It is bitter and pungent in flavor and slightly cold in nature. It enters liver, heart and lung meridians. Has effects of clearing heat and removing toxic substances, improving eyesight and removing nebula, and can be used for treating pharyngitis, brain pain, nasal obstruction and odontalgia. Unblocking orifices and dispelling stagnated fire. "(compendium of materia Medica). Can be used for treating conjunctival congestion, swelling and pain, nebula, eye shade, aphtha, and odontopathy.
Peppermint extract: the product is a saturated cyclic alcohol white crystal obtained by steam distilling fresh leaves and stems of herba Menthae of Labiatae, freezing, and recrystallizing. Has special fragrance of herba Menthae, and cool and refreshing after initial burning. The preparation is used for skin or mucosa, and has effects of refreshing, relieving itching, diminishing inflammation, relieving pain, promoting blood circulation, and relieving edema. It can be used as wind-dispelling medicine for treating headache, nose, pharynx and laryngitis.
The borneol is colorless transparent or white semitransparent flaky crisp crystal; fragrant smell, pungent and cool taste; the product is volatile and easy to sublimate; is easily dissolved in ethanol, chloroform, gasoline or diethyl ether, and is hardly dissolved in water. The melting point is 208 ℃ and the boiling point is 212 ℃.
The herba Menthae extract is colorless needle or prismatic crystal or white crystalline powder; has special fragrance of herba Menthae, and cool after initial burning; is easy to dissolve in organic solvent such as ethanol, etc., and is very slightly dissolved in water. The melting point is 41-43 ℃ and the boiling point is 212 ℃.
The borneol and the mint extract are mixed to form a eutectic mixture, and liquefaction can occur. (a mixture in which wetting or liquefying phenomenon occurs after two or more drugs are mixed, which is called "eutectic mixture". The "eutectic mixture" can greatly lower the melting point and boiling point of each constituent drug). The liquefaction generated when the borneol and the mint extract are mixed does not affect the curative effect of the medicine at all, but can greatly reduce the melting point (8-10 ℃) and boiling point (90 ℃) of the mixture and greatly improve the uniformity of the mixture.
The borneol and the mint extract are transdermal absorption promoters in the traditional Chinese medicine preparation, the borneol and the mint extract are firstly mixed to generate liquefaction, the melting point (8-10 ℃) and the boiling point of the mixture are reduced, the uniformity of the mixture is improved, the targeting enhancement effect of the mixture of the borneol and the mint extract is increased, and then the targeting positioning treatment is utilized to effectively and directly reach focus by matching with the use of bear gall powder and other traditional Chinese medicines, so that the lesion tissue of the oral cavity is quickly penetrated, the lesion tissue cells are repaired, the immunocompetence of autologous cells is activated, the respiratory immune system function is improved, and the purposes of quick and long-acting treatment, simultaneous treatment of both symptoms and root causes and health care of the respiratory system are achieved.
Detailed Description
The present invention will be described in further detail with reference to the following examples in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
Example 1
The seven-orifice rhinitis-relieving spray comprises the following raw materials: the invention takes biological immunotherapy as a core, and uses the targeted positioning treatment advantages to effectively and directly reach focus, quickly permeate nasal cavity pathological tissues, repair pathological tissue cells, activate autologous cell immunocompetence, improve respiratory immune system function and achieve the purposes of quickly and effectively treating both symptoms and root causes and protecting respiratory systems.
Example 2
The invention discloses a seven-orifice rhinitis-relieving spray, which comprises the following raw materials in parts by weight, based on 1000ml, 50g of fructus xanthil, 50g of radix scutellariae, 30g of radix sileris, 30g of flos magnoliae, 10g of Tongguan powder, 10g of spanishneedles herb, 10g of myrobalan, 8g of fructus akebiae, 8g of saffron, 4g of bear gall powder, 2g of borneol and 2g of mint extract.
Example 3
The invention discloses a seven-orifice rhinitis-relieving spray, which comprises the following raw materials in parts by weight, based on 1000ml, 70g of fructus xanthil, 70g of radix scutellariae, 50g of radix sileris, 50g of flos magnoliae, 30g of Tongguan powder, 30g of spanishneedles herb, 30g of myrobalan, 12g of fructus akebia, 12g of saffron, 8g of bear gall powder, 5g of borneol and 5g of mint extract.
Example 4
The invention discloses a seven-orifice rhinitis-relieving spray, which comprises the following raw materials by weight of 1000ml, namely 60g of cocklebur fruit, 60g of baical skullcap root, 40g of divaricate saposhnikovia root, 40g of magnolia flower, 20g of Tongguan powder, 20g of spanishneedles herb, 20g of myrobalan, 10g of fructus akebia, 10g of saffron, 6g of bear gall powder, 3g of borneol and 3g of mint extract.
Example 5
On the basis of examples 1-4, the active ingredient ursodeoxycholic acid content in bear gall powder is 47%, and the invention is prepared by the compatibility of 1 animal medicine (bear gall powder) and 11 medicinal materials mainly produced in Yunnan and marble (fructus Xanthii, radix scutellariae, radix sileris, flos magnoliae, tongguan powder, sticktight, myrobalan, fructus kaki, saffron, borneol and mint extracts). The formula fully considers the traditional Chinese medicine theories such as the nature and taste of the traditional Chinese medicine, the meridian tropism, the compatibility tabu and the like, is a model of combining animal medicines with plant medicines, and has broad-spectrum antibacterial and anti-inflammatory symptomatic effects on nasal diseases. Can be used for treating resuscitation, detumescence, dispelling pathogenic wind, and clearing heat. Can be used for treating acute and chronic rhinitis, sinusitis, nasal obstruction, headache, turbid nasal discharge, odor, and olfactory failure.
Example 6
On the basis of examples 1-4, the active ingredient ursodeoxycholic acid content in bear gall powder is 50%, and the invention is prepared by the compatibility of 1 animal medicine (bear gall powder) and 11 medicinal materials mainly produced in Yunnan and marble (fructus Xanthii, radix scutellariae, radix sileris, flos magnoliae, tongguan powder, sticktight, myrobalan, fructus kaki, saffron, borneol and mint extracts). The formula fully considers the traditional Chinese medicine theories such as the nature and taste of the traditional Chinese medicine, the meridian tropism, the compatibility tabu and the like, is a model of combining animal medicines with plant medicines, and has broad-spectrum antibacterial and anti-inflammatory symptomatic effects on nasal diseases. Can be used for treating resuscitation, detumescence, dispelling pathogenic wind, and clearing heat. Can be used for treating acute and chronic rhinitis, sinusitis, nasal obstruction, headache, turbid nasal discharge, odor, and olfactory failure.
Example 7
On the basis of examples 1-4, the active ingredient ursodeoxycholic acid content in bear gall powder is 53%, and the invention is prepared by the compatibility of 1 animal medicine (bear gall powder) and 11 medicinal materials mainly produced in Yunnan and marble (fructus Xanthii, radix scutellariae, radix sileris, flos magnoliae, tongguan powder, sticktight, myrobalan, fructus kaki, saffron, borneol and mint extracts). The formula fully considers the traditional Chinese medicine theories such as the nature and taste of the traditional Chinese medicine, the meridian tropism, the compatibility tabu and the like, is a model of combining animal medicines with plant medicines, and has broad-spectrum antibacterial and anti-inflammatory symptomatic effects on nasal diseases. Can be used for treating resuscitation, detumescence, dispelling pathogenic wind, and clearing heat. Can be used for treating acute and chronic rhinitis, sinusitis, nasal obstruction, headache, turbid nasal discharge, odor, and olfactory failure.
Example 8
The spray for treating rhinitis comprises the following raw materials of 50g of fructus xanthil, 50g of radix scutellariae, 30g of radix sileris, 30g of flos magnoliae, 10g of Tongguan powder, 10g of sticktight, 10g of myrobalan, 8g of fructus akebiae, 8g of saffron, 4g of bear gall powder, 2g of borneol and 2g of mint extract by taking 1000ml as a raw material.
The preparation method of the seven-orifice rhinitis spray comprises the following steps:
s1, parching fructus Xanthii to brown, adding nine materials of fructus Xanthii, radix Scutellariae, radix Ledebouriellae, flos Magnoliae, TONGGUAN powder, herba Bidentis Bipinnatae, fructus Chebulae, fructus Jun Caesalpiniae, stigma croci Sativi, adding 5 times of water for the first time, decocting for 4 hours, adding 2 times of water for the second time, decocting for 3 hours, mixing decoctions, and filtering for use;
s2, adding 500ml of water into bear gall powder, heating and boiling for 10 minutes to dissolve, and cooling for later use;
s3, adding ethanol into borneol and mint extracts to fully dissolve the borneol and the mint extracts, adding equal amount of water, filtering after microcrystal is separated out, and washing the microcrystal with water for many times until no alcohol smell exists; mixing the microcrystalline with the above medicinal liquid, adding water to 1000ml, filtering, and packaging.
For the production process, the raw materials are separately treated and added according to a certain sequence, and the mixture of borneol and mint extract is fully considered and applied to form a eutectic mixture, so that the liquefaction phenomenon can occur, the melting point and the boiling point of the mixture are greatly reduced, and the uniformity of the mixture is greatly improved.
Example 9
The spray for treating rhinitis comprises 1000ml of fructus Xanthii 70g, scutellariae radix 70g, radix Saposhnikoviae 50g, flos Magnoliae 50g, TONGGUO powder 30g, herba Bidentis Bipinnatae 30g, fructus Chebulae 30g, fructus Jun, fructus Querci Acutissimae 12g, stigma croci Sativi 12g, fel Ursi powder 8g, borneolum Syntheticum 5g, and herba Menthae extract 5g.
The preparation method of the seven-orifice rhinitis spray comprises the following steps:
s1, parching fructus Xanthii to brown, adding nine materials of fructus Xanthii, radix Scutellariae, radix Ledebouriellae, flos Magnoliae, TONGGUAN powder, herba Bidentis Bipinnatae, fructus Chebulae, fructus Jun Caesalpiniae, stigma croci Sativi, adding 5 times of water for the first time, decocting for 4 hours, adding 2 times of water for the second time, decocting for 3 hours, mixing decoctions, and filtering for use;
s2, adding 500ml of water into bear gall powder, heating and boiling for 10 minutes to dissolve, and cooling for later use;
s3, adding ethanol into borneol and mint extracts to fully dissolve the borneol and the mint extracts, adding equal amount of water, filtering after microcrystal is separated out, and washing the microcrystal with water for many times until no alcohol smell exists; mixing the microcrystalline with the above medicinal liquid, adding water to 1000ml, filtering, and packaging.
For the production process, the raw materials are separately treated and added according to a certain sequence, and the mixture of borneol and mint extract is fully considered and applied to form a eutectic mixture, so that the liquefaction phenomenon can occur, the melting point and the boiling point of the mixture are greatly reduced, and the uniformity of the mixture is greatly improved.
Example 10
The spray for treating rhinitis comprises 1000ml of the raw materials including 60g of fructus xanthil, 60g of radix scutellariae, 40g of radix sileris, 40g of flos magnoliae, 20g of Tongguan powder, 20g of spanishneedles herb, 20g of myrobalan, 10g of fructus akebiae, 10g of saffron, 6g of bear gall powder, 3g of borneol and 3g of mint extract.
The preparation method of the seven-orifice rhinitis spray comprises the following steps:
s1, parching fructus Xanthii to brown, adding nine materials of fructus Xanthii, radix Scutellariae, radix Ledebouriellae, flos Magnoliae, TONGGUAN powder, herba Bidentis Bipinnatae, fructus Chebulae, fructus Jun Caesalpiniae, stigma croci Sativi, adding 5 times of water for the first time, decocting for 4 hours, adding 2 times of water for the second time, decocting for 3 hours, mixing decoctions, and filtering for use;
s2, adding 500ml of water into bear gall powder, heating and boiling for 10 minutes to dissolve, and cooling for later use;
s3, adding ethanol into borneol and mint extracts to fully dissolve the borneol and the mint extracts, adding equal amount of water, filtering after microcrystal is separated out, and washing the microcrystal with water for many times until no alcohol smell exists; mixing the microcrystalline with the above medicinal liquid, adding water to 1000ml, filtering, and packaging.
For the production process, the raw materials are separately treated and added according to a certain sequence, and the mixture of borneol and mint extract is fully considered and applied to form a eutectic mixture, so that the liquefaction phenomenon can occur, the melting point and the boiling point of the mixture are greatly reduced, and the uniformity of the mixture is greatly improved.
Years of practical experience proves that the Chinese medicinal composition has the advantages of being capable of achieving good effects of coordinating yin and yang, supplementing each other, promoting the medicinal effect together and treating nasal diseases, being free of reaction such as contraindication and medicinal toxicology, greatly guaranteeing the medicinal safety and effectiveness, avoiding adverse reaction (ADR) of medicaments in clinical tests for years, and being high in medicinal safety. The formula of the seven-orifice rhinitis-relieving spray fully considers the traditional Chinese medicine theory of the traditional Chinese medicines such as the nature and taste, the meridian tropism, the compatibility tabu and the like, is a model of combining animal medicines with plant medicines, and has broad-spectrum antibacterial and anti-inflammatory symptomatic effects on nasal diseases. Can be used for treating resuscitation, detumescence, dispelling pathogenic wind, and clearing heat. Can be used for treating acute and chronic rhinitis, sinusitis, nasal obstruction, headache, turbid nasal discharge, odor, and olfactory failure. The seven-orifice rhinitis spray is an effective method for treating chronic nasosinusitis of children.
Application example
Clinical observation of treating chronic nasosinusitis of children by using nasal cavity compression aerosol inhalation of the seven-orifice rhinitis treatment spray prepared in the embodiment 10 of the invention shows that the specific experimental steps and experimental results are as follows:
1. data and method
1.1 general data: 2016-06 to 2018-06 were selected for children with chronic sinusitis who were diagnosed at the clinic of the people's hospitals in Dazhou, 210 cases of patients with chronic sinusitis, 134 cases of men and 76 cases of women, aged 3-12 years, and on average 6.8 years, 71% were children aged 4-8 years, with the course of disease being 4 weeks. Clinically, the nasal obstruction and nasal discharge of different degrees are manifested as emergent headache and night snoring of partial children. Sinus level or sinus CT reveals a high density shadow within the sinus. All infants had a large amount of mucopurulent secretions in the nasal cavities, 107 cases of obvious turbinate enlargement (51%), 63 cases of moderate adenoid hypertrophy (30%) and 24 cases of exudative otitis media (11%).
1.2 treatment 210 infants were randomized into A, B, C groups of 70.
Conventional treatment group (a): all children patients adopt oral nasosinusitis oral liquid; carrying out nasal cavity negative pressure suction treatment on the infant with more nasal secretion, wherein the nasal cavity negative pressure suction treatment is carried out 1 time a day; for the infant suffering from exudative otitis media, on the basis of nasal cavity negative pressure suction, eustachian tube inflation treatment is selected according to the condition of the infant, 1 time/d, and 2 weeks.
Adjuvant Shu Liang treatment group (B): on the basis of group A, auxiliary Shu Liang is added to spray nose for 2 times/d, and each time of spraying is carried out for 2 weeks.
Seven-orifice rhinitis-relieving spray treatment group (C): on the basis of group A, spraying nasal spray with QIQIAOTONGBIYAN spray for 1mL each time, spraying from nasal cavity by compression pump (PARI SINUS, bairui company, germany) for 2 times/d, spraying for 5min each time, and continuously treating for 2 weeks.
1.3 efficacy assessment criteria
1.3.1 out-patient review: and carrying out curative effect assessment according to the subjective symptoms of the infant and the nasal endoscopic examination, paranasal sinus CT or X-ray film taking results.
And (3) curing: the infant has no subjective symptoms, the mucous membrane is normal in the nasal endoscopic examination, and the X-ray shooting of CT of the paranasal sinuses is not abnormal;
the method is effective: there are mild tolerable subjective symptoms, nasal endoscopy with mild congestion and edema of nasal mucosa, little secretions in nasal cavity, and sinus CT or X-ray film show mild inflammatory response;
invalidation: has severe subjective symptoms, the nasal mucosa is obviously abnormal in the nasal endoscopic examination, a large amount of secretion in the nasal cavity, and the nasal sinus CT or X-ray film shows nasal sinus inflammation
1.3.2 telephone follow-up: the parents can know the illness state of the children, 4 groups of symptoms of nasal obstruction, nasal discharge, headache and snoring are taken as indexes, and the grade I is that: no symptoms; grade II mild symptoms; class III: the symptoms are obvious. The group 4 symptoms are cured when the group I symptoms are all of the grade I, and the group 4 symptoms are improved when the group II symptoms exist; it is ineffective when there is a class III symptom.
1.4 statistical treatment: statistical analysis tables were performed using the SPSS 13.0 statistical software package.
Table 1A, B, C comparative efficacy of the treatment after 1 month (%)
Note that: p <0.01 compared to group C.
2. Results
2.1 out-patient review
A. The comparison of the recheck curative effects after 1 month of B, C treatment is shown in Table 1, and the difference of cure rates of 3 groups is statistically significant (P < 0.01).
2.2 follow-up of electric syndrome
Telephone follow-up was performed 3 months after all infants. The results were judged by questionnaire performed on parents of the infant. The cure rate and the total effective rate of the children patients in the 3 groups are reduced, the A group is 9 percent and 44 percent, the B group is 24 percent and 56 percent, the C group is 40 percent and 77 percent, the difference of the cure rates of the 3 groups is statistically significant (P < 005), the difference of the total effective rates of the A group and the C group and the difference of the total effective rates of the B group and the C group is statistically significant (P < 0.01), and the difference of the total effective rates of the A group and the B group is not statistically significant (P > 0.05).
3. Discussion of the invention
The current and more consistent views are: the pediatric sinusitis should be treated conservatively, and endoscopic surgical treatment should be considered only if systemic medication is ineffective. Even if surgical treatment is selected, the sinus mucosa is reserved as much as possible in the operation, and the surgical range is controlled as much as possible. Mucosal edema caused by infection and allergy is a main cause of nasosinusitis, and can cause rapid blockage of a narrow sinus orifice and a drainage channel, partial tissue hypoxia and cilia activity weakening, so that a good basic environment is provided for pathogen colonisation, and malignant circulation of mucosal inflammation is promoted. Therefore, anti-inflammatory and anti-edema has become a key link for treating the sinusitis of children. The study shows that the traditional Chinese medicine composition has certain curative effect on the sinusitis of children, the total effective rate of the group A is 48%, the total effective rate of the group B is 61%, the total effective rate of the group A is improved compared with that of the group A, the total effective rate of the group C is 84%, and the group C is treated by adding the seven-orifice rhinitis-relieving spray on the basis of the group A. The Chinese medicinal component bear gall contained in the spray for treating rhinitis for seven orifices has the pharmacological functions of clearing heat and detoxicating, inhibiting bacteria and resisting inflammation, dispelling wind and dredging orifices, resisting allergy and the like, so that the spray can relieve inflammatory reaction, congestion and edema of mucous membrane in the rhinitis and nasosinusitis process. The compressed aerosol inhalation machine special for nasosinusitis treatment is selected, and the pulse shock pressure wave is utilized to enable the medicine particles of the nasosinusitis-dredging spray to be more easily diffused to the deep part and the fissure of the nasal cavity, so that the nasosinusitis-dredging spray has wide anti-inflammatory and detumescence effects. The Chinese medicinal spray has effects of hot compress, moistening, mechanical vibration, fine massage and drug comprehensive treatment, and can promote local blood circulation, sterilize and effectively inhibit virus propagation. The results show that the cure rate of the chronic nasosinusitis of the group C children is obviously improved compared with the prior drug treatment, the curative effect is obviously better than that of the two A, B groups, and the results show thatThe use of the seven-orifice rhinitis-relieving spray is an effective method for treating the chronic nasosinusitis of children,thus, the invention can The technical effects of the invention and the technical problems which can be solved are achieved.
Although the invention has been described herein with reference to a number of illustrative embodiments thereof, it should be understood that numerous other modifications and embodiments can be devised by those skilled in the art that will fall within the scope and spirit of the principles of this disclosure. More specifically, various variations and modifications may be made to the component parts and/or arrangements of the subject combination arrangement within the scope of the disclosure and claims of this application. In addition to variations and modifications in the component parts and/or arrangements, other uses will be apparent to those skilled in the art.
Claims (6)
1. The application of the seven-orifice rhinitis-relieving composition in preparing nasal cavity disease spray comprises the following components: fructus Xanthii, radix Scutellariae, radix Saposhnikoviae, flos Magnoliae, TONGGUO powder, herba Bidentis Bipinnatae, fructus Chebulae, fructus Jun Cao Zhao, stigma croci Sativi, fel Ursi powder, borneolum Syntheticum and herba Menthae extract.
2. The use according to claim 1, the nasal cavity disease comprising: one or more of acute rhinitis, chronic rhinitis, sinusitis, nasal obstruction, headache, turbid nasal discharge odor and olfactory failure.
3. The use according to claim 1, the components of the spray being: based on 1000ml, 50-70g of fructus xanthii, 50-70g of radix scutellariae, 30-50g of radix sileris, 30-50g of flos magnoliae, 10-30g of Tongguansan, 10-30g of spanishneedles herb, 10-30g of myrobalan, 8-12g of fructus akebiae, 8-12g of saffron, 4-8g of bear gall powder, 2-5g of borneol and 2-5g of mint extract.
4. The use according to claim 1, the components of the spray being: taking 1000ml as a meter, 60g of fructus xanthil, 60g of radix scutellariae, 40g of radix sileris, 40g of flos magnoliae, 20g of Tongguan powder, 20g of sticktight, 20g of myrobalan, 10g of fructus kaki, 10g of saffron, 6g of bear gall powder, 3g of borneol and 3g of mint extract.
5. The use according to claim 1, wherein the active ingredient ursodeoxycholic acid content of the bear gall powder in the spray is 47% -53%.
6. The use according to any one of claims 1-5, wherein the spray is prepared by the steps of:
s1, parching fructus Xanthii to brown, adding nine materials of fructus Xanthii, radix Scutellariae, radix Ledebouriellae, flos Magnoliae, TONGGUAN powder, herba Bidentis Bipinnatae, fructus Chebulae, fructus Jun Caesalpiniae, stigma croci Sativi, adding 5 times of water for the first time, decocting for 4 hours, adding 2 times of water for the second time, decocting for 3 hours, mixing decoctions, and filtering for use;
s2, adding 500ml of water into bear gall powder, heating and boiling for 10 minutes to dissolve, and cooling for later use;
s3, adding ethanol into borneol and mint extracts to fully dissolve the borneol and the mint extracts, adding equal amount of water, filtering after microcrystal is separated out, and washing the microcrystal with water for many times until no alcohol smell exists; mixing the microcrystalline with the above medicinal liquid, adding water to 1000ml, filtering, and packaging.
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