CN105851592A - Sow mastitis feed additive with slow-release effect and preparation method - Google Patents

Sow mastitis feed additive with slow-release effect and preparation method Download PDF

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Publication number
CN105851592A
CN105851592A CN201610370793.5A CN201610370793A CN105851592A CN 105851592 A CN105851592 A CN 105851592A CN 201610370793 A CN201610370793 A CN 201610370793A CN 105851592 A CN105851592 A CN 105851592A
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parts
sow
feed addictive
release effect
slow release
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袁国防
周丽萍
王小雅
孙彦龙
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Qingdao Haizhiyuan Intelligent Technology Co Ltd
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Qingdao Haizhiyuan Intelligent Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/429Thiazoles condensed with heterocyclic ring systems
    • A61K31/43Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/78Saururaceae (Lizard's-tail family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/86Violaceae (Violet family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/80Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
    • Y02P60/87Re-use of by-products of food processing for fodder production

Abstract

The invention discloses a sow mastitis feed additive with a slow-release effect and a preparation method. The sow mastitis feed additive comprises the following components: bean pulp, wheat bran, corn, grape skin, olive oil, vitamin C, penicillin, streptomycin, houttuynia cordata, Chinese violet, dandelion, radix bupleuri, angelica sinensis, atractylodes macrocephala, radix paeoniae alba, poria cocos, honey-fried licorice roots, mint, ginger, chitosan, methylcellulose, powdered sugar, inorganic salt, polysorbate and superfine silica powder. The preparation method comprises the following steps: preparing the materials, extracting effective components of traditional Chinese raw material medicines, pelletizing and granulating. By adopting the feed additive for treating sow mastitis and with the slow-release effect, medicines can be released in a long-lasting and slow manner, and the blood concentration is stable and small in fluctuation, so that the administration frequency can be reduced, the concentration of effective medicinal components in the blood can be controlled so as to maintain the medicine effect, the medicine release peak times can be reduced, and organs of sows and piglets can be also protected.

Description

A kind of sow mammitis feed addictive with slow release effect and preparation method
Technical field
The invention belongs to field of feed additive technology, be concretely a kind of sow milk with slow release effect Room inflammation feed addictive and preparation method.
Background technology
Sow mammitis is a kind of disease that milking sow is relatively conventional.The enteron aisle bacterium property mammitis morbidity of sow Rate is higher, according to stop breast phase sow ptomatopsia statistics show, sow occur macroscopic mammitis pathology Up to 82%, its death rate of piglet of morbidity sow lactation is 55.8%, and the piglet of normal sow lactation is dead Rate is only 17.2%.The enteron aisle bacterium causing sow mammitis mainly include Escherichia, Klebsiella, Enterobacter and citric acid bacterium genus, these bacteriums are prevalent in sow and surrounding environment, and at any time can Enough polluting nipple, if environment temperature is suitable, it is it is possible to breed rapidly and cause sow to fall ill.Felt In the breast tissue of dye, bacterium by free or in macrophage presented in lumen of gland, but bacterium is not Certain invasion and attack breast tissue from mammary gland chamber, has some cases to divide from frontal bone lymph node and inguinal lymph nodes From to bacterium.
The cause of disease of mammitis is extremely complex, is often caused by many factors.It is commonly considered as due to sow nipple Bitten by piglet or cross, in ground friction or weather, the pathogen sense that the reasons such as frostbite make skin of nipple damage Dye.Pig house health is bad and causes pathogenic bacterial infection (common pathogen have staphylococcus, streptococcus, Pseudomonas aeruginosa, enteropathogenic E. Coli, corynebacterium pyogenes and tubercle bacillus etc.).The primary portion of non-breast The inflammation of position, such as endometritis, it is possible to occur focus transfer that mammitis occurs.Feed big before and after sow Amount fermentation and succulent fodder, polygalactia, stagnate in breast, the most often cause mammitis.Clinical condition Shape includes: 1) sick pig breast red and swollen heat pain, does not allow piglet eat breast.2) body temperature raises, lassitude, food It is intended to go down or useless exhausted.3) lactation reduces, and sick just milk is thin water sample, after become pus sample, containing floccule.
The preventing and treating of sow mammitis at present is fed with hello the amount of material except subtracting before Farrowing, and delivery room to be cleaned and to defend Outside sterilization raw, dry, regular, it is simply that injection cordate houttuynia adds the Western medicine preparations such as spore ceftiofur sodium.
Summary of the invention
It is an object of the present invention to provide a kind of sow mammitis feed addictive with slow release effect and preparation side Method.The feed addictive of the present invention uses the effect of Integrated TCM to regulate sow physical condition, can be effective Prevention and treatment sow suffer from mammitis and sick pig breast red and swollen heat pain occur, do not allow piglet eat breast;Body temperature raises, Lassitude, anorexia or useless exhausted;Lactation reduces, and sick just milk is thin water sample, after become pus sample, Containing floccule;Improve the economic benefit of plant.
The present invention seeks to be realized by techniques below scheme:
A kind of sow mammitis feed addictive with slow release effect, each component of this feed addictive and weight Number includes: dregs of beans 40~50 parts, wheat bran 30~40 parts, corn 40~50 parts, grape skin 20~30 parts, Olive oil 50~60 parts, vitamin C 5~10 parts, penicillin 3~5 parts, streptomysin 3~5 parts, cordate houttuynia 50~60 Part, Chinese violet 40~45 parts, dandelion 50~60 parts, radix bupleuri 35~40 parts, Radix Angelicae Sinensis 35~40 parts, white Art 25~30 parts, the root of herbaceous peony 30~35 parts, Poria cocos 25~30 parts, honey-fried licorice root 40~45 parts, peppermint 40~45 parts, Ginger 45~50 parts, chitosan 10~15 parts, methylcellulose 15~20 parts, Icing Sugar 20~25 parts, Inorganic salts 3~5 parts, polysorbate 1~3 parts, superfine silica gel powder 1~3 parts.
Further, the object of the invention can also be realized by techniques below scheme:
A kind of sow mammitis feed addictive with slow release effect, each component of this feed addictive and weight Number includes: dregs of beans 40 parts, 30 parts of wheat bran, corn 40 parts, grape skin 20 parts, 50 parts of olive oil, Vitamin C 5 parts, 3 parts of penicillin, streptomysin 3 parts, cordate houttuynia 50 parts, Chinese violet 40 parts, Pu Gong English 50 parts, radix bupleuri 35 parts, Radix Angelicae Sinensis 35 parts, the bighead atractylodes rhizome 25 parts, the root of herbaceous peony 30 parts, 25 parts of Poria cocos, process sweet Grass 40 parts, peppermint 40 parts, 45 parts of ginger, chitosan 10 parts, methylcellulose 15 parts, sugar 20 parts of powder, 3 parts of inorganic salts, polysorbate 1 part, superfine silica gel powder 1 part.
A kind of sow mammitis feed addictive with slow release effect, each component of this feed addictive and weight Number includes: dregs of beans 50 parts, 40 parts of wheat bran, corn 50 parts, grape skin 30 parts, 60 parts of olive oil, Vitamin C 10 parts, 5 parts of penicillin, streptomysin 5 parts, cordate houttuynia 60 parts, Chinese violet 45 parts, Pu Public English 60 parts, radix bupleuri 40 parts, Radix Angelicae Sinensis 40 parts, the bighead atractylodes rhizome 30 parts, the root of herbaceous peony 35 parts, 30 parts of Poria cocos, process 45 parts of Radix Glycyrrhizae, peppermint 45 parts, 50 parts of ginger, chitosan 15 parts, methylcellulose 20 parts, Icing Sugar 25 parts, 5 parts of inorganic salts, polysorbate 3 parts, superfine silica gel powder 3 parts.
A kind of sow mammitis feed addictive with slow release effect, each component of this feed addictive and weight Number includes: dregs of beans 45 parts, 34 parts of wheat bran, corn 47 parts, grape skin 22 parts, 55 parts of olive oil, Vitamin C 7 parts, 4 parts of penicillin, streptomysin 4 parts, cordate houttuynia 56 parts, Chinese violet 43 parts, Pu Gong English 54 parts, radix bupleuri 37 parts, Radix Angelicae Sinensis 39 parts, the bighead atractylodes rhizome 27 parts, the root of herbaceous peony 32 parts, 28 parts of Poria cocos, process sweet Grass 44 parts, peppermint 41 parts, 48 parts of ginger, chitosan 12 parts, methylcellulose 18 parts, sugar 23 parts of powder, 4 parts of inorganic salts, polysorbate 2 parts, superfine silica gel powder 2 parts.
Present invention also offers the preparation method of a kind of sow mammitis feed addictive with slow release effect, Comprise the steps:
1) get the raw materials ready, according to each component of described a kind of sow mammitis feed addictive with slow release effect And parts by weight get the raw materials ready;Wherein dregs of beans, wheat bran, corn, grape skin pulverized 30 mesh sieves respectively, and dimension is raw 120 mesh sieves pulverized respectively by element C, penicillin, streptomysin, chitosan, methylcellulose, Icing Sugar, Inorganic salts, polysorbate, superfine silica gel powder pulverized 80 mesh sieves respectively;
2) extraction of Chinese medicine material pharmaceutically active ingredient, adds pure water in Chinese medicine extracting tank, opens stirring, The consumption of pure water is 10 times of Chinese medicine material medicine gross weight number, by Chinese medicine material medicine cordate houttuynia, pale reddish brown Fourth, dandelion, radix bupleuri, Radix Angelicae Sinensis, the bighead atractylodes rhizome, the root of herbaceous peony, Poria cocos, honey-fried licorice root, peppermint, ginger add Chinese medicine In extractor, the temperature of charge in Chinese medicine extracting tank being warming up to 85~90 DEG C, constant temperature extracts 1h, 12 layers of yarn Cloth filters, and filtrate is standby, is again returned to by filter residue in Chinese medicine extracting tank, adds and extracts equal weight for the first time The pure water of amount number, opens stirring, the temperature of charge in Chinese medicine extracting tank is warming up to 85~90 DEG C, constant temperature Extracting 1h, 12 layers of filtered through gauze, filtrate is standby;Merge twice gained filter vacuum and be concentrated into former filter before concentration Liquid long-pending 1/8th Chinese medical extract;
3) pelletize, by vitamin C, penicillin, streptomysin, chitosan, methylcellulose, sugar Powder, inorganic salts, polysorbate, superfine silica gel powder mix, wet granulation, and cross the 20 whole grains of mesh sieve;
4) granulation, by dregs of beans, wheat bran, corn, grape skin, step 3) gained particle ground by extrusion Platen press granulation, dispenses standby.
A kind of preparation method of the sow mammitis feed addictive with slow release effect of the present invention, it is also possible to Realized by techniques below scheme:
A kind of preparation method of the sow mammitis feed addictive with slow release effect, described Chinese medicine material medicine The extraction step vacuum concentration process parameter of active ingredient is: pressure is-0.07~-0.08Mpa, temperature is 40~45 DEG C.
A kind of preparation method of the sow mammitis feed addictive with slow release effect, described granulation step institute Being fluid bed with drying equipment, technological parameter is: EAT is 55~60 DEG C, and temperature of charge is 45~50 DEG C, Leaving air temp is 35~40 DEG C.
A kind of preparation method of the sow mammitis feed addictive with slow release effect, described granulation step institute Being fluid bed with drying equipment, technological parameter is: EAT is 45~50 DEG C, and temperature of charge is 35~40 DEG C, Leaving air temp is 30~35 DEG C.
In order to effectively prevent and treat sow to suffer from the sick pig breast red and swollen heat pain of mammitis appearance, piglet is not allowed to eat breast; Body temperature raises, lassitude, anorexia or useless exhausted;Lactation reduces, and sick just milk is thin water sample, after Become pus sample, containing floccule;Improve the economic benefit of plant.The present invention uses controlling of Integrated TCM Treatment method, through a large amount of screening tests, screens Chinese and Western medicine bulk drug and feed ingredient, refining preparation Method so that each component effect produces synergy, thus reaches the effect treated both principal and secondary aspect of disease.
The Chinese medicine material medical instrument chosen has that bactericidal antiphlogistic, soothing liver and strengthening spleen, nourishing blood for regulating menstruation, promoting the circulation of qi be active, stagnation resolvation Dissipating bind, the effect of tonifying middle-Jiao and Qi, selected Chinese medicine material medicine:
Cordate houttuynia, taste is pungent, cold, returns lung channel.Clearing heat and detoxicating, detumescence can treat sore, promoting urination and removing dampness, clear Heat only dysentery, stomach strengthening and digestion promoting, with controlling real heat, heat poison, damp evil, disease heat are the lung carbuncle of trouble, sore swollen toxin, hemorrhoid Sore is had blood in stool, retention of heat in the spleen and stomach etc..Modern pharmacology experiment shows, this product has antibacterial, antiviral, raising body Immunity, diuresis etc. act on.
Chinese violet, taste bitter, acrid, cold.The thoughts of returning home, lung channel.Having clearing heat and detoxicating, cool blood is subsided a swelling, heat-clearing The effect of dampness removing, cures mainly furunculosis, and carbuncle swells, scrofula, jaundice, dysentery, diarrhoea, hot eyes, larynx numbness, poisonous snake Bite.
Dandelion, bitter but sweet flavor, cold in nature;It is included into liver, stomach warp;Function cures mainly: clearing heat and detoxicating, diuresis dissipating bind. Control acute mastitis, adenolymphitis, scrofula, malignant boil carbuncle toxin, acute conjunctivitis, cold, fever, acute flat Peach body is scorching, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infections.
Radix bupleuri, bitter, cold nature, return liver, gallbladder channel.In having and inducing sweat, soothing the liver effect rising sun.For Cold, fever, fevers and chills alternate, malaria, stagnation of QI due to depression of the liver, sternal rib pain, prolapse of the anus, the prolapse of uterus, menstruation are not Adjust.
Radix Angelicae Sinensis, taste is sweet, pungent, warm in nature;Return liver, the heart, the spleen channel;Replenishing and activating blood, menstruction regulating and pain relieving, ease constipation is led to Just.There is 1. oxygen lack resistant function;2. regulate body's immunity, there is antitumaous effect;3. improve looks Effect;4. replenishing and activating blood effect;The most antibacterial, anti arteriosclerosis effect.
The bighead atractylodes rhizome, bitter, sweet, warm in nature.Return spleen, stomach warp.Strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive. Few for insufficiency of the spleen food, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.
The root of herbaceous peony, bitter, acid, cold nature;Return liver, the spleen channel;Flat liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating. For dizziness of having a headache, hypochondriac pain, stomachache, four limbs contraction pain, the deficiency of blood is sallow, irregular menstruation, spontaneous perspiration, night sweat.
Poria cocos, slightly sweet flavor, property is put down;Return Liver Channel, stomach warp, the spleen channel;Removing toxic substances, dehumidifying, profit joint;Control plum Poison, stranguria with turbid discharge, muscles and bones contraction pain, tinea pedis, treat furunculosis, carbuncle swells, scrofula, the limbs caused by syphilis and mercury poisoning Contraction, arthralgia and myalgia.
Honey-fried licorice root, containing multiple chemical compositions such as glycyrrhizin, enoxolone, licorice polysaccharides, has anti-inflammatory And anti-allergy action, adjustable body's immunity, antitumor and analgesic effect.Honey-fried licorice root main Effect is and middle emergency, moistening lung, removing toxic substances, coordinating the drug actions of a prescription.It is usually used in weakness of the spleen and the stomach, lassitude hypodynamia, aroused in interest Throb with fear, intermittent pulse, monkshood poison can be solved.
Peppermint, taste is pungent, cool in nature;Enter lung, Liver Channel.There is antivirus action, analgesia, itching-relieving action, resist Stimulation, antitussive action, anti-inflammatory and antibacterial effect, stomach invigorating and wind action of dispelling, fragrance and the effect of seasoning, Mainly utilize refrigerant throat-moistening specific to peppermint and the pleasant smell of fragrance is covered up and improved some and has peculiar smell With the sense of discomfort being difficult to the medicine swallowed.
Ginger, its active ingredient is zingiberene, has the effect of protection Gastric Mucosal Cells.At fragrance stomach invigorating crude drug In, particularly many containing terpene derived essential oils such as zingiberenes in zingiberaceous plant, be the raw the effective elements of the medicine of stomach invigorating it One.The water extract of ginger has significant absorption enhancement effect, strengthens its bioavilability, gives full play to treat Effect.Ginger has resisting pathogenic microbes effect, and ginger extract is to staphylococcus aureus, white grapes ball Bacterium, typhoid bacillus, bacterium sonnei, Pseudomonas aeruginosa all have obvious inhibiting effect, its effect with concentration in Dependence.Especially the inhibitory action with staphylococcus aureus and staphylococcus albus is the strongest.Gingerade preserved material exists External have strong bactericidal action to typhoid bacillus and comma bacillus, in vitro trichophyta is had inhibitory action, Zingiberol in race stem and gingerol have to be killed mollusk and kills bilharzial effect, can be used for treating blood Fluke disease.Ginger mud and ginger leachate have obvious facilitation to wound healing.
A kind of sow mammitis feed addictive with slow release effect of the present invention, uses modern advanced doctor Medicine technology of preparing, fully extracts Chinese medicine material the effective elements of the medicine, prepares Chinese medical extract, selected all medicines: Penicillin, streptomysin anti-inflammation, cordate houttuynia is clearing heat and detoxicating, detumescence treatment sore is monarch drug in a prescription, is mainly used in treatment Sow mammitis.Cordate houttuynia has antibacterial, antiviral, to improve immunity of organisms effect, it is possible to auxiliary green grass or young crops Mycin, streptomysin anti-inflammation, improve sow immunity, promote sow to get well faster.Purple Flower Chinese violet, dandelion auxiliary cordate houttuynia for clearing heat and detoxicating, radix bupleuri and in inducing sweat, root of herbaceous peony strengthening the spleen and replenishing qi, dry Wet profit water can improve body immunity, promotes sow to get well faster;Above Chinese violet, Dandelion, radix bupleuri, the root of herbaceous peony are ministerial drug altogether, and it is scorching that auxiliary is used for treating Gilt Uterus.Radix Angelicae Sinensis taste is sweet, pungent, property Temperature, replenishing and activating blood, regulate body's immunity, auxiliary cordate houttuynia, radix bupleuri, the root of herbaceous peony improve sow immunity, Sow is promoted to get well faster;Bighead atractylodes rhizome bitter, sweet, warm in nature, strengthening the spleen and replenishing qi and Radix Angelicae Sinensis are altogether for assistant Medicine.Poria cocos slightly sweet flavor, property are flat, return Liver Channel, stomach warp, the spleen channel;Honey-fried licorice root has anti-inflammatory and antiallergic action Effect, adjustable body's immunity;Mint flavored is pungent, cool in nature, enters lung, Liver Channel, has antivirus action, Analgesia, itching-relieving action, anti-irritant, antitussive action, anti-inflammatory and antibacterial effect;Above Poria cocos, honey-fried licorice root, Peppermint is altogether for making medicine, and effect is and middle emergency, removing toxic substances, coordinating the drug actions of a prescription.Peppermint also has anti-inflammatory and antibacterial work With, it is possible to auxiliary penicillin, streptomysin anti-inflammation, and peppermint has the smell of fragrance, it is possible to improve With cover the bad smell of other medicines, improve appetite.Ginger is for drawing, it is possible to draws and reaches medicine to sow breast Scorching position, allows medicament to preferably play curative effect, and additionally ginger also has the work of protection Gastric Mucosal Cells With.Other medicine injured one's stomach damage to stomach lining can be prevented;Ginger also has resisting pathogenic microbes effect, Can assist antibacterial-anti-inflammatory drug that Gilt Uterus inflammation is had the effect of anti-inflammation.
Beneficial effects of the present invention
1) present invention uses that bactericidal antiphlogistic, soothing liver and strengthening spleen, nourishing blood for regulating menstruation, promoting the circulation of qi be active, blood stasis-eliminating and stagnation-dissipating, benefit The treatment means of middle benefit gas, carry out collaborative treatment of Chinese and western medicines, selected all medicines to sow mammitis: penicillin, Streptomysin anti-inflammation, cordate houttuynia is clearing heat and detoxicating, detumescence treatment sore is monarch drug in a prescription, is mainly used in treating sow breast Scorching.Cordate houttuynia has antibacterial, antiviral, to improve immunity of organisms effect, it is possible to auxiliary penicillin, chain Mycin anti-inflammation, improves sow immunity, promotes sow to get well faster.Chinese violet, Dandelion auxiliary cordate houttuynia for clearing heat and detoxicating, radix bupleuri and in inducing sweat, root of herbaceous peony strengthening the spleen and replenishing qi, eliminating dampness profit water energy Enough improve body immunity, promote sow to get well faster;Above Chinese violet, dandelion, Radix bupleuri, the root of herbaceous peony are ministerial drug altogether, and it is scorching that auxiliary is used for treating Gilt Uterus.Radix Angelicae Sinensis taste is sweet, pungent, warm in nature, enriches blood Invigorating blood circulation, regulate body's immunity, auxiliary cordate houttuynia, radix bupleuri, the root of herbaceous peony are improved sow immunity, promote mother Pig can get well faster;Bighead atractylodes rhizome bitter, sweet, warm in nature, strengthening the spleen and replenishing qi and Radix Angelicae Sinensis are adjutant altogether.Fu Siberian cocklebur slightly sweet flavor, property are flat, return Liver Channel, stomach warp, the spleen channel;Honey-fried licorice root has anti-inflammatory and anti-allergy action, Adjustable body's immunity;Mint flavored is pungent, cool in nature, enters lung, Liver Channel, has antivirus action, ease pain, Itching-relieving action, anti-irritant, antitussive action, anti-inflammatory and antibacterial effect;Above Poria cocos, honey-fried licorice root, peppermint Altogether for making medicine, effect is and middle emergency, removing toxic substances, coordinating the drug actions of a prescription.Peppermint also has anti-inflammatory and antibacterial effect, Penicillin, streptomysin anti-inflammation can be assisted, and peppermint has the smell of fragrance, it is possible to improve and cover The bad smell of lid other medicines, improves appetite.Ginger is for drawing, it is possible to draws and reaches medicine to sow mammitis Position, allows medicament to preferably play curative effect, and additionally ginger also has the effect of protection Gastric Mucosal Cells. Other medicine injured one's stomach damage to stomach lining can be prevented;Ginger also has resisting pathogenic microbes effect, it is possible to Auxiliary antibacterial-anti-inflammatory drug has the effect of anti-inflammation to Gilt Uterus inflammation.
2) present invention uses modern advanced medical technology of preparing, fully extracts Chinese medicine material the effective elements of the medicine, Preparing Chinese medical extract, Chinese medical extract and Western medicine, feed ingredient common combination are prepared by the present invention together Feed addictive.
3) dregs of beans, the corn that add in inventive formulation can improve feed addictive mouthfeel by preparation technology, Promote sow feed.The anthocyanidin contained in Grape Skin, more than pulp, has protection tiny blood vessels, resists and send out Scorching effect, is possible to prevent sow breast inflammation, promotes sow Recovery.Contained olive oil is rich in abundant Monounsaturated fatty acids oleic acid, also vitamin A, Cobastab, vitamin D, vitamin E, dimension Raw element K and polyphenoils etc.;Digestive system function can be improved, be beneficial to digest and assimilate, also there is food calling effect. Vitamin C has been also equipped with anti-oxidant in addition to having the function strengthening immunity of organisms, Green Tea Extract, suppresses junket The formation of propylhomoserin enzyme.The present invention adds olive oil and vitamin C can make the more stable existence of other component.
4) chitosan that adds in the formula of the present invention, methylcellulose, Icing Sugar, inorganic salts, poly- Sorb ester, superfine silica gel powder mix through pelletizing with Chinese medical extract, granulation step gained feed addictive Being capable of internal discharging medicine persistently, slowly, blood concentration is steady, fluctuates little, thus reduces administration Frequency, control active drug composition concentration in blood, to maintain drug effect, reduces insoluble drug release and reaches peak The internal organs of sow and piglet are also had certain protection by number.
5) each component of feed addictive of the treatment sow mammitis with slow release effect of the present invention is green Environmental protection raw material, nontoxic to sow and piglet, simple to operation, in use can direct feeding sow, Sow mammitis is had good result for the treatment of, and cure rate is up to more than 90%;It is internal lasting, slow to be capable of Slow release medicine, blood concentration is steady, fluctuates little, thus reduces administration frequency, controls active drug and becomes Concentration point in blood, to maintain drug effect, reduces insoluble drug release and reaches peak number of times, dirty to sow and piglet Device also has certain protection.But also sow is had certain food calling effect, promote the fast quick-recovery of sow, increase Strong immunity, the beneficially sustainable health development of sow aquaculture, and drug residue free, after edible healing Sow meat do not interfere with the healthy of people, improve the economic benefit of raiser.To sow institute milk piglet Also there are certain prevention and the effect for the treatment of gastrointestinal disease.
Detailed description of the invention
Below in conjunction with embodiments of the invention, technical scheme is clearly and completely described.
Embodiment 1
A kind of sow mammitis feed addictive with slow release effect, each component of this feed addictive and weight Number includes: dregs of beans 40 parts, 30 parts of wheat bran, corn 40 parts, grape skin 20 parts, 50 parts of olive oil, Vitamin C 5 parts, 3 parts of penicillin, streptomysin 3 parts, cordate houttuynia 50 parts, Chinese violet 40 parts, Pu Gong English 50 parts, radix bupleuri 35 parts, Radix Angelicae Sinensis 35 parts, the bighead atractylodes rhizome 25 parts, the root of herbaceous peony 30 parts, 25 parts of Poria cocos, process sweet Grass 40 parts, peppermint 40 parts, 45 parts of ginger, chitosan 10 parts, methylcellulose 15 parts, sugar 20 parts of powder, 3 parts of inorganic salts, polysorbate 1 part, superfine silica gel powder 1 part.
The preparation method of a kind of sow mammitis feed addictive with slow release effect, comprises the steps:
1) get the raw materials ready, according to each component of described a kind of sow mammitis feed addictive with slow release effect And parts by weight get the raw materials ready;Wherein dregs of beans, wheat bran, corn, grape skin pulverized 30 mesh sieves respectively, and dimension is raw 120 mesh sieves pulverized respectively by element C, penicillin, streptomysin, chitosan, methylcellulose, Icing Sugar, Inorganic salts, polysorbate, superfine silica gel powder pulverized 80 mesh sieves respectively;
2) extraction of Chinese medicine material pharmaceutically active ingredient, adds pure water in Chinese medicine extracting tank, opens stirring, The consumption of pure water is 10 times of Chinese medicine material medicine gross weight number, by Chinese medicine material medicine cordate houttuynia, pale reddish brown Fourth, dandelion, radix bupleuri, Radix Angelicae Sinensis, the bighead atractylodes rhizome, the root of herbaceous peony, Poria cocos, honey-fried licorice root, peppermint, ginger add Chinese medicine In extractor, the temperature of charge in Chinese medicine extracting tank being warming up to 85~90 DEG C, constant temperature extracts 1h, 12 layers of yarn Cloth filters, and filtrate is standby, is again returned to by filter residue in Chinese medicine extracting tank, adds and extracts equal weight for the first time The pure water of amount number, opens stirring, the temperature of charge in Chinese medicine extracting tank is warming up to 85~90 DEG C, constant temperature Extracting 1h, 12 layers of filtered through gauze, filtrate is standby;Merge twice gained filter vacuum and be concentrated into former filter before concentration Liquid long-pending 1/8th Chinese medical extract;Vacuum concentration process parameter is: pressure for-0.07~-0.08Mpa, Temperature is 40~45 DEG C;
3) pelletize, by vitamin C, penicillin, streptomysin, chitosan, methylcellulose, sugar Powder, inorganic salts, polysorbate, superfine silica gel powder mix, wet granulation, and cross the 20 whole grains of mesh sieve;Institute Being fluid bed with drying equipment, technological parameter is: EAT is 55~60 DEG C, and temperature of charge is 45~50 DEG C, Leaving air temp is 35~40 DEG C;
4) granulation, by dregs of beans, wheat bran, corn, grape skin, step 3) gained Chinese medical extract passes through Extrusion rolled-on method granulation, dispenses standby;Drying equipment used is fluid bed, and technological parameter is: EAT Being 45~50 DEG C, temperature of charge is 35~40 DEG C, and leaving air temp is 30~35 DEG C.
Using method: by feed addictive every day 2 times of the present invention, each 0.7kg/ head is fed to ill sow.
Embodiment 2
A kind of sow mammitis feed addictive with slow release effect, each component of this feed addictive and weight Number includes: dregs of beans 50 parts, 40 parts of wheat bran, corn 50 parts, grape skin 30 parts, 60 parts of olive oil, Vitamin C 10 parts, 5 parts of penicillin, streptomysin 5 parts, cordate houttuynia 60 parts, Chinese violet 45 parts, Pu Public English 60 parts, radix bupleuri 40 parts, Radix Angelicae Sinensis 40 parts, the bighead atractylodes rhizome 30 parts, the root of herbaceous peony 35 parts, 30 parts of Poria cocos, process 45 parts of Radix Glycyrrhizae, peppermint 45 parts, 50 parts of ginger, chitosan 15 parts, methylcellulose 20 parts, Icing Sugar 25 parts, 5 parts of inorganic salts, polysorbate 3 parts, superfine silica gel powder 3 parts.
The preparation method of the present embodiment and using method are with embodiment 1.
Embodiment 3
A kind of sow mammitis feed addictive with slow release effect, each component of this feed addictive and weight Number includes: dregs of beans 45 parts, 34 parts of wheat bran, corn 47 parts, grape skin 22 parts, 55 parts of olive oil, Vitamin C 7 parts, 4 parts of penicillin, streptomysin 4 parts, cordate houttuynia 56 parts, Chinese violet 43 parts, Pu Gong English 54 parts, radix bupleuri 37 parts, Radix Angelicae Sinensis 39 parts, the bighead atractylodes rhizome 27 parts, the root of herbaceous peony 32 parts, 28 parts of Poria cocos, process sweet Grass 44 parts, peppermint 41 parts, 48 parts of ginger, chitosan 12 parts, methylcellulose 18 parts, sugar 23 parts of powder, 4 parts of inorganic salts, polysorbate 2 parts, superfine silica gel powder 2 parts.
The preparation method of the present embodiment and using method are with embodiment 1.
Embodiment 4
Application Example
Test site is selected in pig farm, Weifang, in order to verify prevention and the result for the treatment of of the present invention, to postpartum Once there is breast red and swollen heat pain in sow, did not allow piglet eat breast;Body temperature raises, lassitude, anorexia Or it is useless exhausted;Lactation reduces, and sick just milk is thin water sample, after become pus sample, enter containing phenomenons such as floccules Row test.
It is divided into 4 groups, often group 10, respectively control group, test A group, test B group, test C group, Concrete test method is as follows:
Control group: intramuscular injection penicillin 500,000 units/head, streptomysin 500,000 units/head, every day 1 time, continuously Inject 5 days.
Test A group: interpolation feed every day prepared by the embodiment of the present invention 12 times, each 0.7kg/ head (phase When in penicillin 500,000 units/head, streptomysin 500,000 units/head) it is fed to sow in postpartum, continuous feeding 5 My god.
Test B group: the interpolation feed every day embodiment of the present invention 2 prepared 2 times, each 0.7kg/ head is fed Food is to sow in postpartum, continuous feeding 5 days.
Test C group: the interpolation feed every day embodiment of the present invention 3 prepared 2 times, each 0.7kg/ head is fed Food is to sow in postpartum, continuous feeding 5 days.
Experimental result is shown in Table 1:
The feed addictive of table 1 present invention prevention and result for the treatment of to producing stepmother's swine udder
By table 1 data it can be seen that the feed addictive of the present invention has well prevention to sow mammitis And result for the treatment of, cure rate has reached more than 90%, significantly larger than intramuscular injection penicillin, the treatment side of streptomysin , there is not lopsided piglet in method, and piglet survival ratio is greatly improved, the feed addictive prevention of the present invention and treatment Effect is obvious.
The above is the preferred embodiment of the present invention, its object is to allow person skilled in the art understand Present invention is also carried out, it is noted that for those skilled in the art, Without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications are also It is considered as protection scope of the present invention.

Claims (8)

1. a sow mammitis feed addictive with slow release effect, it is characterised in that this feed adds The each component of agent and parts by weight include: dregs of beans 40~50 parts, wheat bran 30~40 parts, corn 40~50 parts, Portugal Grape skin slag 20~30 parts, olive oil 50~60 parts, vitamin C 5~10 parts, penicillin 3~5 parts, streptomysin 3~5 parts, cordate houttuynia 50~60 parts, Chinese violet 40~45 parts, dandelion 50~60 parts, radix bupleuri 35~40 Part, Radix Angelicae Sinensis 35~40 parts, the bighead atractylodes rhizome 25~30 parts, the root of herbaceous peony 30~35 parts, Poria cocos 25~30 parts, honey-fried licorice root 40~45 Part, peppermint 40~45 parts, ginger 45~50 parts, chitosan 10~15 parts, methylcellulose 15~20 Part, Icing Sugar 20~25 parts, inorganic salts 3~5 parts, polysorbate 1~3 parts, superfine silica gel powder 1~3 parts.
A kind of sow mammitis feed addictive with slow release effect the most according to claim 1, its Being characterised by, each component of this feed addictive and parts by weight include: dregs of beans 40 parts, 30 parts of wheat bran, jade 40 parts of rice, grape skin 20 parts, 50 parts of olive oil, vitamin C 5 parts, 3 parts of penicillin, streptomysin 3 Part, cordate houttuynia 50 parts, Chinese violet 40 parts, dandelion 50 parts, radix bupleuri 35 parts, Radix Angelicae Sinensis 35 parts, white Art 25 parts, the root of herbaceous peony 30 parts, 25 parts of Poria cocos, honey-fried licorice root 40 parts, peppermint 40 parts, 45 parts of ginger, de- Chitosan 10 parts, methylcellulose 15 parts, Icing Sugar 20 parts, 3 parts of inorganic salts, polysorbate 1 part, Superfine silica gel powder 1 part.
A kind of sow mammitis feed addictive with slow release effect the most according to claim 1, its Being characterised by, each component of this feed addictive and parts by weight include: dregs of beans 50 parts, 40 parts of wheat bran, jade 50 parts of rice, grape skin 30 parts, 60 parts of olive oil, vitamin C 10 parts, 5 parts of penicillin, streptomysin 5 parts, cordate houttuynia 60 parts, Chinese violet 45 parts, dandelion 60 parts, radix bupleuri 40 parts, Radix Angelicae Sinensis 40 parts, The bighead atractylodes rhizome 30 parts, the root of herbaceous peony 35 parts, 30 parts of Poria cocos, honey-fried licorice root 45 parts, peppermint 45 parts, 50 parts of ginger, Chitosan 15 parts, methylcellulose 20 parts, Icing Sugar 25 parts, 5 parts of inorganic salts, polysorbate 3 Part, superfine silica gel powder 3 parts.
A kind of sow mammitis feed addictive with slow release effect the most according to claim 1, its Being characterised by, each component of this feed addictive and parts by weight include: dregs of beans 45 parts, 34 parts of wheat bran, jade 47 parts of rice, grape skin 22 parts, 55 parts of olive oil, vitamin C 7 parts, 4 parts of penicillin, streptomysin 4 Part, cordate houttuynia 56 parts, Chinese violet 43 parts, dandelion 54 parts, radix bupleuri 37 parts, Radix Angelicae Sinensis 39 parts, white Art 27 parts, the root of herbaceous peony 32 parts, 28 parts of Poria cocos, honey-fried licorice root 44 parts, peppermint 41 parts, 48 parts of ginger, de- Chitosan 12 parts, methylcellulose 18 parts, Icing Sugar 23 parts, 4 parts of inorganic salts, polysorbate 2 parts, Superfine silica gel powder 2 parts.
5. the preparation method of a sow mammitis feed addictive with slow release effect, it is characterised in that Comprise the steps:
1) get the raw materials ready, according to a kind of sow mammitis with slow release effect described in any one of Claims 1 to 4 Each component of feed addictive and parts by weight are got the raw materials ready;Wherein dregs of beans, wheat bran, corn, grape skin are respectively Pulverizing 30 mesh sieves, 120 mesh sieves pulverized respectively by vitamin C, penicillin, streptomysin, and deacetylated shell is many Sugar, methylcellulose, Icing Sugar, inorganic salts, polysorbate, superfine silica gel powder pulverized 80 mesh sieves respectively;
2) extraction of Chinese medicine material pharmaceutically active ingredient, adds pure water in Chinese medicine extracting tank, opens stirring, The consumption of pure water is 10 times of Chinese medicine material medicine gross weight number, by Chinese medicine material medicine cordate houttuynia, pale reddish brown Fourth, dandelion, radix bupleuri, Radix Angelicae Sinensis, the bighead atractylodes rhizome, the root of herbaceous peony, Poria cocos, honey-fried licorice root, peppermint, ginger add Chinese medicine In extractor, the temperature of charge in Chinese medicine extracting tank being warming up to 85~90 DEG C, constant temperature extracts 1h, 12 layers of yarn Cloth filters, and filtrate is standby, is again returned to by filter residue in Chinese medicine extracting tank, adds and extracts equal weight for the first time The pure water of amount number, opens stirring, the temperature of charge in Chinese medicine extracting tank is warming up to 85~90 DEG C, constant temperature Extracting 1h, 12 layers of filtered through gauze, filtrate is standby;Merge twice gained filter vacuum and be concentrated into former filter before concentration Liquid long-pending 1/8th Chinese medical extract;
3) pelletize, by vitamin C, penicillin, streptomysin, chitosan, methylcellulose, sugar Powder, inorganic salts, polysorbate, superfine silica gel powder mix, wet granulation, and cross the 20 whole grains of mesh sieve;
4) granulation, by dregs of beans, wheat bran, corn, grape skin, step 3) gained particle ground by extrusion Platen press granulation, dispenses standby.
The system of a kind of sow mammitis feed addictive with slow release effect the most according to claim 5 Preparation Method, it is characterised in that the extraction step vacuum concentration process parameter of described Chinese medicine material pharmaceutically active ingredient For: pressure is-0.07~-0.08Mpa, temperature is 40~45 DEG C.
The system of a kind of sow mammitis feed addictive with slow release effect the most according to claim 5 Preparation Method, it is characterised in that drying equipment used by described granulation step is fluid bed, technological parameter is: enter Air temperature is 55~60 DEG C, and temperature of charge is 45~50 DEG C, and leaving air temp is 35~40 DEG C.
The system of a kind of sow mammitis feed addictive with slow release effect the most according to claim 5 Preparation Method, it is characterised in that drying equipment used by described granulation step is fluid bed, technological parameter is: enter Air temperature is 45~50 DEG C, and temperature of charge is 35~40 DEG C, and leaving air temp is 30~35 DEG C.
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CN108077578A (en) * 2017-12-29 2018-05-29 常德惠生九鼎食品有限公司 It is a kind of for the Chinese medicine composition of postpartum sow and feed and preparation method thereof
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CN115053936A (en) * 2022-06-10 2022-09-16 正百生物科技(江门)有限公司 Slow-release feed essential oil preparation and preparation method thereof
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Application publication date: 20160817