CN107260844A - A kind of bacteriostasis spray - Google Patents

A kind of bacteriostasis spray Download PDF

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Publication number
CN107260844A
CN107260844A CN201710492568.3A CN201710492568A CN107260844A CN 107260844 A CN107260844 A CN 107260844A CN 201710492568 A CN201710492568 A CN 201710492568A CN 107260844 A CN107260844 A CN 107260844A
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parts
beans
raw material
bacteriostasis spray
medicine
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刘道忠
刘骞
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention belongs to technical field of Chinese medicine, there is provided a kind of beans beans bacteriostasis spray, it is characterised in that described pharmaceutical preparation is calculated by weight, is made up of the medicine material of following weight proportion：8 15 parts of radix scutellariae, 15 20 parts of kuh-seng, 10 20 parts of honeysuckle, 15 25 parts of dandelion, 10 18 parts of the coptis, 25g parts of the root bark of shaggy-fruited dittany 15,0.05 0.1 parts of Fluconazole raw material, 0.05 0.2 parts of Fusidic Acid, 0.05 0.2 parts of Tinidazole.This beans beans bacteriostasis spray mild in medicine property and but effect is absorbed and effectual, non-stimulated, no allergic reaction, can effectively disappear rapidly acne, have no toxic side effect, and obvious effective rate reaches more than 82%, and total effective rate reaches more than 90%, and uneasy to recur.

Description

A kind of bacteriostasis spray
Technical field
The invention belongs to technical field of Chinese medicine, specially a kind of beans beans bacteriostasis spray.
Background technology
Acne is commonly called as " whelk ", " whelk " measles risen in puberty face are easily mistakenly considered by majority, cross Puberty will self-healing.Just because of this, the acne such as many patients influences beauty just to go to see the doctor." whelk " be not single in fact It is puberty, can also occurs childhood minority or the middle age." whelk " it is patient facial region's pilosebaceous follicle chronic inflammation Disease property disease, is one of most common disease of dept. of dermatology." whelk " if effective treatment not in time, developing as one pleases will shadow Ring the beautiful distinguished face of patient.Its morbidity is mainly largely secreted with sex hormone level, sebaceous glands, propionibacterium acnes propagation, hair follicle The factors such as the dyskeratosis and inflammation of sebaceous gland duct are related.The illness is apt to occur in hebetic masculinity and femininity, and male is slightly more In women, but women morbidity is earlier than male.The teenager for having 80-90% suffered from acne, and nature decline is tended to after puberty or is fullyed recover from an illness More, few patients can also extend to more than 30 years old.Although acne is the disease for having self-healing to be inclined to, acne is in itself and acne Caused scar can have a strong impact on the quality of life of patient not in time for treatment, cause stress and the financial burden of patient, Concern need to be caused.Acne is apt to occur in cheek, forehead, cheek and nasolabial groove, next to that chest, back and shoulder.
Existing medicine has Chinese medicine and Western medicine.It is mostly mould using antisterone, metronidazole, happiness in western medicine Element is treated, but curative effect is not notable.The traditional Chinese medical science thinks that acne is that lung channel is hot and suffocating, and interior heat is flourishing, outside by caused by ailment said due to cold or exposure, rules for the treatment of master If mansion is led in facilitaing lung heat-clearing, dampness elimination.
Thus, the present invention targetedly prepares a kind of antibacterial spray of external application beans beans as raw material using Chinese herbal medicine and Western medicine Agent.
The content of the invention
The invention aims to overcome the deficiencies in the prior art, and targetedly design a kind of antibacterial spray of beans beans Agent.
To achieve the above object, the present invention provides following technical scheme：
A kind of beans beans bacteriostasis spray, the weight proportion of material composition is as follows：8-15 parts of radix scutellariae, 15-20 parts of kuh-seng, honeysuckle 10- 20 parts, 15-25 parts of dandelion, 10-18 parts of the coptis, 15-25g parts of the root bark of shaggy-fruited dittany, 0.05-0.1 parts of Fluconazole raw material, Fusidic Acid 0.05-0.2 parts, 0.05-0.2 parts of Tinidazole.
Preferably, the beans beans bacteriostasis spray, includes following formula components according to mass fraction：10 parts of radix scutellariae, kuh-seng 15 Part, 16 parts of honeysuckle, 18 parts of dandelion, 14 parts of the coptis, 20 parts of the root bark of shaggy-fruited dittany, 0.05 part of Fluconazole raw material, Fusidic Acid raw material 0.1 Part, 0.08 part of Tinidazole raw material.
Preferably, beans beans bacteriostasis spray as described above, it is prepared to external preparation, at least including cream, ointment.
Modern Western medicine thinks, this disease is mainly with androgen and sebaceous glands hyperfunction, the taste of microorganism in hair follicle sebum Raw, the immunologic function of host is low relevant.Modern Chinese herbal medicine thinks, face nose belongs to lung, wind and heat in the lung meridian, and powder can be caused in skin by fumigating Thorn.The rules for the treatment of need facilitaing lung heat-clearing, dampness elimination to lead to mansion.
Modern pharmacology research is proved：
Honeysuckle, radix scutellariae, kuh-seng, heat-clearing accompany, eliminating dampness, invigorate blood circulation as monarch drug in a prescription.Wherein, honeysuckle is sweet cold in nature, clearing heat and detoxicating, can It is individually used for treating furunculosis；Radix scutellariae is sweet cold in nature, heat-clearing and damp-drying drug, purging intense heat and detonicating；Kuh-seng heat-clearing and damp-drying drug, desinsection is antipruritic, antibacterial, resists Inflammation, antiallergy.
Dandelion, the coptis, the root bark of shaggy-fruited dittany are clearing heat and detoxicating, are altogether adjuvant.Wherein dandelion bitter but sweet flavor is cold in nature, have it is clearing heat and detoxicating, The effect of dampness removing, associated with honeysuckle, the clearing heat and detoxicating effect of honeysuckle can be strengthened；Coptis heat-clearing and damp-drying drug, purging intense heat and detonicating；Shaggy-fruited dittany Skin heat-clearing and damp-drying drug, wind-dispelling removing toxic substances.
Fluconazole, belongs to pyroles antifungal.To people and various animal fungal infections, such as monilial infection（Including immune The systemic candidiasis of the humans and animals of normal or immunocompromised host）, C. neoformans infection（Including intracranial infection）, chaff horse Draw color bacterium, Microsporon, trichophyton, Epidermophyton, Blastomyces dermatitidis, posadasis spheriforme（Including intracranial infection）And pod Membrane tissue endochylema bacterium, Fei Shi chomophoric bacteriums, Cladosporium carrionii etc. are effectively.The mechanism of action of the product is mainly that high selectivity interference is true The activity of the cytochrome P-450 of bacterium, so as to suppress the biosynthesis of ergosterol on fungal cell membrane.The toxicity product are to fungi The cytochrome P-450 enzyme of dependence has high selectivity.
Fusidic Acid is a kind of antibiotic with steroid backbone, is synthesized by the protein for suppressing bacterium, and plays suppression Bacterium or bactericidal action.There is stronger antibacterial to make staphylococcus (including methicillin-resistance strain or the strain of other resistance to antibiotic) With also there is certain antibacterial to make to streptococcus, enterococcus, corynebacterium diphtheriae, clostruidium, neisseria and tubercle bacillus With.
Tinidazole, has greater activity to protozoon and anaerobic bacteria, to the Bacteroides such as bacteroides fragilis, Fusobacterium, clostridium Category, peptococcus, peptostreptococcus, Wei Rong Coccus and Jia get Na bacterium etc. have antibacterial activity, and 2~4mg/L concentration can suppress Most of anaerobic bacterias；Microaerobion, helicobacter pylori are sensitive to it；It is similar to the MIC and metronidazole of Trichomonas vaginalis, its metabolin Activity to Jia get Na bacterium compared with Tinidazole is strong.
Above-mentioned all medicine combinations are made after external preparation, are applied to affected part, be can reach clearing heat and cooling blood, removing toxic substances ecchymose removing, are detoxified logical Network, clearing heat-fire, rapid antipruritic function, it is adaptable to treat various types of acnes.
The advantages of the present invention and advantage are：This beans beans bacteriostasis spray is to Cuo based on modern Chinese medicine with doctor trained in Western medicine The pathogenetic understanding of sore and principle of reatment, selected Chinese and western medical raw material, are formulated using unique formula.The medicament property of medicine Gentle but effect is absorbed and effectual, non-stimulated, no allergic reaction, can effectively disappear rapidly acne, have no toxic side effect, obvious effective rate More than 82% is reached, total effective rate reaches more than 90%, and uneasy to recur.
Embodiment
Product of the present invention is further described below in conjunction with the embodiment of the present invention, the description of embodiment is only to readily appreciate It is of the invention with application, rather than to the limitation of the invention protected.Unless stated otherwise, the % in the present invention is mass percent；Remove Non-specifically illustrates that preparation process is carried out under normal temperature, atmospheric pressure state；Unless stated otherwise, the present invention in use reagent, method It is the art conventional reagent, method and apparatus with equipment；Unless stated otherwise, the experimental condition used in the present invention is this Technical field normal test conditions；Unless stated otherwise, agents useful for same is purchased in market in the present invention.
The cream of embodiment 1
Prescription：10 parts of radix scutellariae, 15 parts of kuh-seng, 16 parts of honeysuckle, 18 parts of dandelion, 14 parts of the coptis, 20 parts of the root bark of shaggy-fruited dittany, Fluconazole are former 0.05 part of material, 0.1 part of Fusidic Acid raw material, 0.08 part of Tinidazole raw material.
Preparation method：Described Chinese medicine material is ground into fine powder with pulverizer, 10-20 times of medicinal material gross weight is added and measures Decocting boil 2-3h, filter, collect filtrate；Medicinal material 8-15 times of decocting measured of weight is added in the dregs of a decoction again and boils 1-2h, mistake Filter, collects filtrate, filtrate will merge twice, and be concentrated into the medicinal extract of semisolid, medicinal extract is freeze-dried, crushed 200 mesh sieves, Obtain Chinese medical extract medicinal powder.0.05 part of Fluconazole raw material, 0.1 part of Fusidic Acid raw material, 0.08 part of Tinidazole raw material are taken with Medicament extract medicinal powder is mixed, and is heated in 70~80 DEG C of water-baths, and fusing stirs, after fully emulsified, and stirring is simultaneously Progressively cool down, white emulsifiable paste matrix of having leisure；Another to weigh recipe quantity Chinese medical extract, finely ground crushing crosses No. 9 sieves, adds blank emulsifiable paste Matrix, is stirred evenly, that is, cream is made.
The ointment of embodiment 2
Prescription：：12 parts of radix scutellariae, 18 parts of kuh-seng, 20 parts of honeysuckle, 22 parts of dandelion, 15 parts of the coptis, 22g parts of the root bark of shaggy-fruited dittany, Fluconazole 0.1 part of raw material, 0.2 part of Fusidic Acid, 0.2 part of Tinidazole.
Preparation method：Described Chinese medicine material is ground into fine powder with pulverizer, 15-20 times of medicinal material gross weight is added and measures Decocting boil 3-4h, filter, collect filtrate；Medicinal material 10-18 times of decocting measured of weight is added in the dregs of a decoction again and boils 2-3h, is filtered, Filtrate is collected, filtrate will be merged twice, and be concentrated into the medicinal extract of semisolid, medicinal extract is freeze-dried, crushed 300 mesh sieves, and obtained Chinese medical extract medicinal powder.Take 0.1 part of Fluconazole raw material, 0.2 part of Fusidic Acid raw material, 0.2 part of Tinidazole raw material and traditional Chinese medicine extraction Thing medicinal powder is mixed, and obtains Chinese and Western medicine mixture；Part Chinese and Western medicine mixture is heated in 120~200 DEG C of marmites, melted, together When at intervals of two minutes, add appropriate Chinese and Western medicine mixture and simultaneously stir, after after abundant fusion, stir and simultaneously progressively cool down, obtain ointment Agent.
To verify curative effect of the present invention, inventor has carried out as follows in 2012-2016 in Wuhan City, Hubei Province Li Ji hospitals Clinical trial：
1. clinical data：
The slight of age 15-25 Sui, moderate, the acne patient totally 82 of the severe state of an illness are selected, two groups, one are randomly divided into Group is treatment group, and 42 altogether, another group is control group, altogether 40.
2. document method：
Western medicine is taken by treatment group, antisterone 25mg, metronidazole 25mg, minocycline 40mg, orally, twice a day mouth Clothes, first quarter moon is a course for the treatment of；Daily also applied in affected part uses ointment of the present invention or cream simultaneously, three times per day, and first quarter moon is treated for one Journey.
Control group list takes western medicine, antisterone 25mg, metronidazole 25mg, minocycline 40mg, orally, and daily two Secondary oral, first quarter moon is a course for the treatment of.
3. curative effect judging standard
A. it is notable：Clinical cure, skin damaged all disappears, and subjective symptoms disappears or leaves pigmentation and scar；
B. it is effective：Skin damaged regression more than 30%, subjective symptoms substantially mitigates；
C. it is invalid:Skin damaged and symptom are unchanged, and subjective symptoms regression shape is less than 30%.
4. therapeutic effect：
Table one：Therapeutic effect
Significantly Effectively It is invalid It is total
Treatment group 32 8 2 42
Control group 22 10 8 40
It can be seen that from the data of table one：
First, treatment group：Obvious effective rate is 76.2%；Effective percentage is 19%；Inefficiency is 4.8%.
2nd, control group：Obvious effective rate is 55%；Effective percentage is 25%；Inefficiency is 20%.
Described above is only the preferred application implementation mode of the present invention, it is noted that for the common skill of the art For art personnel, without departing from the technical principles of the invention, some improvements and modifications can also be made, these improve and Retouching also should be regarded as protection scope of the present invention.

Claims (3)

1. a kind of beans beans bacteriostasis spray, it is characterised in that described pharmaceutical preparation is calculated by weight, by following weight proportion Medicine material is made：8-15 parts of radix scutellariae, 15-20 parts of kuh-seng, 10-20 parts of honeysuckle, 15-25 parts of dandelion, 10-18 parts of the coptis, 15-25g parts of the root bark of shaggy-fruited dittany, 0.05-0.1 parts of Fluconazole raw material, 0.05-0.2 parts of Fusidic Acid, 0.05-0.2 parts of Tinidazole.
2. beans beans bacteriostasis spray according to claim 1, it is characterised in that the beans beans bacteriostasis spray, according to mass parts Number includes following formula components：10 parts of radix scutellariae, 15 parts of kuh-seng, 16 parts of honeysuckle, 18 parts of dandelion, 14 parts of the coptis, the root bark of shaggy-fruited dittany 20 Part, 0.05 part of Fluconazole raw material, 0.1 part of Fusidic Acid raw material, 0.08 part of Tinidazole raw material.
3. beans beans bacteriostasis spray according to claim 1, it is characterised in that it is prepared to external preparation, at least includes Cream, ointment.
CN201710492568.3A 2017-06-26 2017-06-26 A kind of bacteriostasis spray Pending CN107260844A (en)

Priority Applications (1)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108379369A (en) * 2018-05-29 2018-08-10 刘骞 A kind of small pox rehabilitation box
CN112089789A (en) * 2020-10-16 2020-12-18 贵州草喜堂医药有限公司 Rosemary nerve-soothing and bacteriostatic spray and production method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108379369A (en) * 2018-05-29 2018-08-10 刘骞 A kind of small pox rehabilitation box
CN112089789A (en) * 2020-10-16 2020-12-18 贵州草喜堂医药有限公司 Rosemary nerve-soothing and bacteriostatic spray and production method thereof

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Application publication date: 20171020