CN105250815B - A kind of Chinese medicine composition and preparation method thereof for treating homeliness type acne - Google Patents

Abstract

The invention discloses a kind of for treating the Chinese medicine composition of homeliness type acne, belongs to technical field of traditional Chinese medicine.The Chinese medicine composition includes Oral preparation and external application lotion；The Oral preparation is decocted by following raw material: fritillaria 7-13 parts by weight, radix scutellariae 9-20 parts by weight, hawthorn 22-40 parts by weight, wild chrysanthemum 4-15 parts by weight, Fructus Forsythiae 10-24 parts by weight, campanulaceae 10-25 parts by weight, gypsum 15-35 parts by weight, Radix Glycyrrhizae 6-15 parts by weight, pollen pini 6-15 parts by weight, root of Dahurain angelica 5-17 parts by weight, gardenia florida 5-15 parts by weight, seed of jog's tears 12-30 parts by weight；It is described to be applied with washing lotion made of the residue after lotion is decocted as Oral preparation boils altogether with 4-15 parts by weight rheum officinale.Chinese medicine composition provided by the invention has good clinical efficacy to homeliness type acne, and has the characteristics that treatment cycle is short, uneasy to recur.

Description

A kind of Chinese medicine composition and preparation method thereof for treating homeliness type acne

Technical field

The present invention relates to technical field of traditional Chinese medicine, and in particular to a kind of for treating the Chinese traditional medicine composition of homeliness type acne Object and preparation method thereof.

Background technique

Homeliness type acne is a kind of pilosebaceous gland chronic inflammation disease that puberty is common, mainly with androgen, Smegma increases, follicular orifice epithelium angling is hyperfunction, and propionibacterium acnes and inherent cause are related, typical lesions be face, Excessive sugar and fat are eaten in chest and back acne, papule, warts, tumour etc., mental element, tobacco and wine and maror stimulation, Exacerbation or precipitating factor can be become.

Acne be multifactor functioning as a result, the main generation with sebum increase, follicular orifice epithelium angling it is high Into and hair follicle in propionibacterium acnes proliferation it is related, also have certain inherent cause.The development of sebaceous glands is dominated by androgen, green The main increase of production of phase in spring androgen, makes sebum hylperadenosis, sebum secretion increases, and sebum is discharged to skin surface by follicular orifice. The follicular epithelium dyskeratosis of patients with acne, epithelial cell cannot normally fall off, and follicular orifice is made to become smaller, and sebum cannot be arranged unimpededly It is deposited out in follicular orifice, forms acne.Normal parasitism has acne propionic acid bar mattress, pityrosporum furfur and epidermis grape ball in hair follicle Bacterium etc., these bacterial multiplications when sebum occurs in hair follicle and is retarded by silt, the enzyme that wherein propionibacterium acnes generate can decompose sebum, produce Main free fatty acid is the major reason that capsule causes inflammatory reaction under stimulation hair.Propionibacterium acnes also generate some low molecules Polypeptide has chemotaxis to neutrophil leucocyte, and the hydrolase that the latter generates makes follicular wall that leakage occur or even rupture, in hair follicle It is tolerant to enter surrounding dermal tissue, cause a series of clinical manifestations from inflamed papules to Cystic damage.

Patient is mostly youth of both sexes, and basic lesions are acne, papule or warts, is apt to occur in the skins such as face, upper chest and back The more position of adipose gland, it is symmetrical, it is not difficult to diagnose.

It treats at present and nursing is mainly the methods of unobstructed using degreasing, dissolution angle, bactericidal antiphlogistic, holding follicular orifice, root It can be treated in the following ways according to its extent:

1. should lack and eat irritable food, commonly uses warm water and wash affected part, it is more preferable with the soap effect containing sulphur.Enjoin patient It keeps away manual-free and squeezes skin lesion, avoid using containing the drugs such as the more cosmetics of grease and long-term use iodide, bromide.

2. the patients with acne based on acne, papule, warts can be treated only with local topical, there are commonly include sulphur, Lei Suoxin etc. has degreasing and dissolves the preparation such as compound sulfur lotion of cutin effect；Antibiotic formulations such as 1% lincomycin fine wine, 2%-4% erythromycin alcohol；5%-10% Benzagel or creme, benzoyl peroxide have sterilization and inhibit the work of sebum secretion With, can obviously reduce propionibacterium acnes quantity, there are also inhibit acne formed effect, have slight stimulation work to skin after external application With use should be suspended if obvious flush.0.05%-0.1% Vintamin-A acid cream has cutin dissolution and the effect of stripping off, and makes acne surface Horn plug is easily removed.Rouge bolt is easy to be discharged.Also there are certain stimulation, such as flush, furfur after external application to skin.More than Externally applied drug individually or should be used cooperatively depending on skin lesion situation.

3. based on tubercle, Cystic damage or skin lesion quantity is more, inflammation bright severe acne patient, except part is controlled Outside treating, it can drink using the following method:

(1) take antibiotic orally: common tetracycline medication, such as tetracycline, the amount of beginning are after 2.0g/d inflammation obviously subsides 0.25-0.5g/d is reduced to, several weeks are continuously taken.Minocycline it is fat-soluble good, readily penetrate through into sebaceous glands, thus antibacterial is made With more significant, administration 100mg/d, 50mg/d maintenance is kept to after inflammatory resolution；Fortimicin 200mg/d, is changed to later 100mg/d is maintained.Tetracycline medication has photosensitization, once photosensitive dermatitis, which occurs, to be deactivated immediately.Other antibiotic Also it can be selected, such as erythromycin 0.5g/d.

(2) isotretinoin (isotretinoin) capsule and pill: have to the secretion of sebaceous glands and relatively sprinkle Buddhist nun's inhibiting effect, also to acne Propionibacterium has inhibiting effect.Oral, the amount of beginning is 0.5-1.0mg/kg.d, general 30-60mg/d, is subtracted after obtaining significant curative effect Amount maintains, and need to take 3-4 months.It may occur in which the side reactions such as xerocheilia, the desquamation of skin, alopecia, blood lipid raising, liver kidney after medication Dysfunction person is used with caution.This medicine has teratogenesis, and child-bearing period men and women duration of medication should practise contraception, and can be pregnant after half a year of being discontinued.

(3) corticosteroid hormone: to serious nodositas, Cystic and acne conglobata patient, prednisone 30- is taken orally 40mg/d has certain curative effect.It can be with triamcinolone suspension (10mg/ml) or prednisolone suspension (5mg/ to a other skin lesion Ml), add 2% procaine a small amount of, injection, 1 times a week, 3-4 times continuous in nodositas, Cystic damage.Long-acting skin can also be used Matter hormone preparation, the interior injection of skin lesion, monthly 1 time.

4. the development of endocrinotherapy sebaceous glands is dominated by androgen, therefore the drug pair with the effect of antagonism male sex hormone Acne has therapeutic effect.But the therapy can cause endocrine disorder, therefore generally not advocate to use, for female patient, It is obviously aggravated in every premenstrual acne, it can be in the last week intramuscular injection progesterone 10mg that passes through.For serious Women with Acne, Stilbestrol can be taken within the 14th day after menstruation starts, daily 1mg continuously takes 2 weeks.

5. physiotherapy liquid nitrogen frozen spray-on process or spot printing are suitable for nodositas or cystic acne.It is available for acne Special acne extruder squeezes out acne content.Facial mask includes that mediated face membrane and gypsum facial mask also can be used.

6. this disease of Chinese medicine is referred to as " lung-wind comedo ", the suitable promoting the dispersing function of the lung heat-clearing of the rules for the treatment of, oral administration PIPA QINGFEI YIN (Radix Codonopsis, loguat leaf, The coptis, the root bark of white mulberry, Cortex Phellodendri, Radix Glycyrrhizae), external application DIANDAO SAN (rheum officinale, sulphur) cold water dresses.

It is found by the applicant that general using western medicine therapeutic effect, effective percentage is 80% or so, and still, many patients are Obstinate, treatment cycle is long, even if after effective, also needing medication a period of time, makes ailing with entire puberty.

Summary of the invention

The present invention provides a kind of for treating the Chinese medicine composition of homeliness type acne, is divided into Oral preparation and external application is washed Agent is applied with lotion and is prepared by the residue for preparing Oral preparation, and preparation is simple, easy to use, meanwhile, the treatment week of the composition Phase is short, and therapeutic effect is good.The technical solution is as follows:

On the one hand, the embodiment of the invention provides a kind of for treating the Chinese medicine composition of homeliness type acne, including for oral administration Agent and external application lotion；

Wherein, decoction made of Oral preparation is decocted as following raw material: fritillaria 7-13 parts by weight, radix scutellariae 9-20 parts by weight, mountain Short, bristly hair or beard 22-40 parts by weight, wild chrysanthemum 4-15 parts by weight, Fructus Forsythiae 10-24 parts by weight, campanulaceae 10-25 parts by weight, gypsum 15-35 weight Measure part, Radix Glycyrrhizae 6-15 parts by weight, pollen pini 6-15 parts by weight, root of Dahurain angelica 5-17 parts by weight, gardenia florida 5-15 parts by weight, seed of jog's tears 12- 30 parts by weight；After decoction, Oral preparation is obtained by filtration, residue is spare to be used to prepare external application lotion.Wherein, being applied with lotion is by preparing Washing lotion made of residue and rheum officinale 4-15 parts by weight after Oral preparation decoction boil altogether, after decoction, filtering, cooling are obtained.

Preferably, Oral preparation is decocted by following raw material: fritillaria 8-10 parts by weight, radix scutellariae 12-16 parts by weight, hawthorn 25-35 parts by weight, wild chrysanthemum 7-12 parts by weight, Fructus Forsythiae 10-20 parts by weight, campanulaceae 15-20 parts by weight, gypsum 20-28 weight Part, Radix Glycyrrhizae 8-13 parts by weight, pollen pini 8-10 parts by weight, root of Dahurain angelica 7-12 parts by weight, gardenia florida 10-12 parts by weight, seed of jog's tears 16-25 Parts by weight；Being applied with lotion is as preparing washing lotion made of the residue after Oral preparation decocts boils altogether with rheum officinale 5-10 parts by weight.

It is highly preferred that the composition of Oral preparation is in parts by weight are as follows: 10 parts by weight of fritillaria, 15 parts by weight of radix scutellariae, 30 weight of hawthorn Measure part, 10 parts by weight of wild chrysanthemum, 15 parts by weight of Fructus Forsythiae, 15 parts by weight of campanulaceae, 25 parts by weight of gypsum, 10 parts by weight of Radix Glycyrrhizae, pine 10 parts by weight of pollen, 10 parts by weight of the root of Dahurain angelica, 10 parts by weight of gardenia florida, 20 parts by weight of the seed of jog's tears；Being applied with lotion is by preparing Oral preparation Washing lotion made of residue and 8 parts by weight of rheum officinale after decoction boil altogether.

Certainly, other medicine types that can be taken orally, such as pill, powder, capsule can also be made in Oral preparation, be applied with Medicine may be the externally applied drug of other forms, such as emulsifiable paste, liniment or ointment.

On the other hand, the embodiment of the invention also provides the preparations for the Chinese medicine composition for being previously used for treatment homeliness type acne Method, should the preparation method comprises the following steps:

(1) preparation of Oral preparation: take according to the ratio fritillaria, radix scutellariae, hawthorn, wild chrysanthemum, Fructus Forsythiae, campanulaceae, gypsum, Radix Glycyrrhizae, Pollen pini, the root of Dahurain angelica, gardenia florida and the seed of jog's tears are merged decoction liquor and are obtained Oral preparation with decocting 2-3 times.

(2) it is applied with the preparation of lotion: according to the ratio boiling decoction residue and rheum officinale that step (1) obtains altogether 1 time, filter, it is cold But lotion must be applied with.

Specifically, in step (1), each decoction 8-15 times that water is raw material weight.

Specifically, in step (2), decoction 5-8 times that water is raw material weight.

Specifically, preceding method includes:

(1) fritillaria 7-13 parts by weight, radix scutellariae 9-20 parts by weight, hawthorn 25-35 parts by weight, mother chrysanthemum the preparation of Oral preparation: are taken Flower 7-12 parts by weight, Fructus Forsythiae 10-20 parts by weight, campanulaceae 10-25 parts by weight, gypsum 15-35 parts by weight, Radix Glycyrrhizae 6-15 weight Part, pollen pini 6-15 parts by weight, root of Dahurain angelica 5-17 parts by weight, gardenia florida 5-15 parts by weight and seed of jog's tears 12-30 parts by weight, with decocting 2- 3 times, each decoction is that raw material is (fritillaria, radix scutellariae, hawthorn, wild chrysanthemum, Fructus Forsythiae, campanulaceae, gypsum, Radix Glycyrrhizae, pollen pini, white with water The root of Dahurian angelica, gardenia florida and the seed of jog's tears) 8-15 times of weight, it is filtered after the completion of decocting, decoction liquor is spare, and filter residue is decocted next time, conjunction And decoction liquor obtains Oral preparation.

(2) it is applied with the preparation of lotion: the decoction residue and rheum officinale 4-15 parts by weight water for according to the ratio obtaining step (1) It boils altogether 1 time, decoction is that raw material is (fritillaria, radix scutellariae, hawthorn, wild chrysanthemum, Fructus Forsythiae, campanulaceae, gypsum, Radix Glycyrrhizae, pollen pini, white with water The root of Dahurian angelica, gardenia florida, the seed of jog's tears and rheum officinale) 5-8 times of weight, filtering is so cooling that be applied with lotion.

Wherein, the application method of Chinese medicine composition are as follows:

The amount of one auxiliary: fritillaria 7-13g, radix scutellariae 9-20g, hawthorn 22-40g, wild chrysanthemum 4-15g, Fructus Forsythiae 10-24g, campanulaceae 10-25g, gypsum 15-35g, Radix Glycyrrhizae 6-15g, pollen pini 6-15g, root of Dahurain angelica 5-17g, gardenia florida 5-15g, seed of jog's tears 12-30g and Rheum officinale 4-15g(is put when doing washing lotion).Daily one is secondary, takes for Oral preparation decocting 2-3 time, residue and 1 washout of Rhei Decoction simultaneously cold compress Affected part.7 days as one therapeutic course, the 2-3 course for the treatment of are cured.

Key agents introduction and drug action mechanism are as follows in the composition of offer of the invention:

Fritillaria is herbaceos perennial, bulb hyoscine, bulbus fritillariae cirrhosae bitter, sweet, cold nature；Fritillaria thunbergii bitter, property It is cold.Return lung, the heart channel of Hang-Shaoyin.It cures mainly phlegm heat cough, exogenous cough, cough due to yin deficiency, phlegm and swallows dry, cough up phlegm yellow thick, pulmonary abscess, acute mastitis, ulcerative carbuncle less The diseases such as pyogenic infections, scrofula.Modern pharmacology is it is demonstrated experimentally that fritillaria has antibechic, decompression, increases the effects of blood glucose.

Radix scutellariae, Labiatae, a kind of medicinal material, Skullcaps eliminate nervous and uneasiness, stablize physical condition.What it contained Radix scutellariae glucoside has anti-inflammatory, anti-allergy action；Hepatoprotective and cholagogic effects；Decompression, diuresis, calmness, refrigeration function；Aldose reductase Inhibiting effect.Clinic is mainly used for catarrhal jaundice, and acute biliary infection, lead poisoning is clearing heat and detoxicating, chest tightness and emesis, lung heat cough It coughs, tumour sore threatened abortion.

Hawthorn (Crataegus pinnatifida Bunge), it is rosaceous plant large-fruited Chinese hawthornCrataegus pin, natiida Or hawthorn Bge.var.majorN.E.Br.Crataegus pin.nati fidaBge. dry mature fruit. For meat stagnation, gastral cavilty turgor, diarrhea dysentery abdominal pain, blood stasis closed, postpartum stasis, confidant sting, chest impediment and cardialgia, hernia pain, Hyperlipidemia.Charred FRUCTUS CRATAEGI promoting digestion effect enhancing.For meat stagnation, dysentery is not well.

Wild chrysanthemum, is composite family herbaceos perennial, and wild chrysanthemum cold nature has dispelling wind and heat from the body, subdhing swelling and detoxicating.Malignant boil can be treated The diseases such as sore carbuncle swollen, abscess of throat, wind-fire red eye, headache and dizziness.

Fructus Forsythiae, Classification system:Forsythia suspensa , it is Oleaceae forsythia, major function: heat-clearing, solution Poison, dissipating bind, detumescence.Control warm, erysipelas, macula, large carbuncle pyogenic infections, scrofula, urine leaching closes.

Campanulaceae, Chinese medicine name.For Campanulaceae campanulaceaePlatycodon grandiflorus(Jacq.) drying of A.Dc. Root.With promoting the dispersing function of the lung, the effect of relieving sore-throat, eliminating the phlegm, apocenosis.For coughing with a lot of sputum, chest distress, pharyngalgia hoarse voice, lung carbuncle pyemesis.

Gypsum, main component are hydrous calcium sulfate, in addition, still having a small amount of silicic acid, aluminium hydroxide, sulfide and micro Iron, magnesium etc..With clearing heat-fire, relieving restlessness is quenched the thirst, convergence myogenic and other effects；The major functions: apoplexy fever and chills, the frightened asthma of heart subinverse gas, dry Tongue is burnt, cannot cease, hardness and fullness in the abdomen pain, evil removing ghost, puerperium metal-inflicted wound.Except when gas headache body heat, three Jiao great Re, skin heat ties in stomach Gas, expelling pathogenic factors from muscles by diaphoresis, only quenching one's thirst, it is inverse to be tired of, the sudden and violent gas of abdominal distension wheezes and swallows heat, can also do bath soup.

Radix Glycyrrhizae is glycyrrhizic legumeGlycyrrhiza uralensisFisch., swollen fruit RadixGlycyrrhiza inflataOr glycyrrhiza glabra Bat.Glycyrrhiza glabraL. dry root and rhizome.Effect: invigorating the spleen and benefiting qi, heat-clearing Removing toxic substances, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.The major functions: it is used for weakness of the spleen and the stomach, fatigue and weakness, and shortness of breath and palpitation, coughing with a lot of sputum, Stomach duct and abdomen, four limbs contraction, carbuncle sore tumefacting virus alleviate drug toxicity, strong.

Pollen is rich in a variety of amino acid, vitamin A, vitamin C, vitamin E, active material and trace elements of selenium, phosphorus The ingredients such as rouge, nucleic acid.Effect: wind-dispelling QI invigorating, hygroscopic, hemostasis.Head rotation dizziness is controlled, middle void has a stomach-ache, and protracted dysentery, all sores are wet rotten, wound Bleeding.Pollen pini includes the nutriments such as multiple proteins, amino acid, minerals, enzyme and coenzyme, nucleic acid, monosaccharide, polysaccharide, always Content is up to more than 200.Pollen pini is warm-natured, sweet in flavor, has nourishing qi and blood, calming the liver wind-dispelling and other effects.

The root of Dahurain angelica, Chinese medicine name, the dry root of the umbelliferae root of Dahurain angelica or Radix angelicae dahuricae.It is used as medicine with root, the dehumidifying that gets rid of illness, apocenosis are raw The functions such as flesh, promoting blood circulation and stopping pain.Cure mainly anemofrigid cold, headache, rhinitis, toothache.The diseases such as leukorrhea with reddish discharge, pain furuncle poison.

Gardenia florida is the fruit of madder wort mountain Cape jasmine (Gardenia jasminoides Ellis).Function is the major functions: clear Heat, purging intense heat, cool blood.Pyreticosis restlessness of asrhenia type and insomnia, jaundice are controlled, stranguria syndrome is quenched one's thirst, hot eyes, pharyngalgia, it spits blood, bleeding from five sense organs or subcutaneous tissue, bloody flux, hematuria, heat toxin Sore sprains swelling and pain.

The seed of jog's tears, major function: dampness removing invigorating the spleen；Relaxing muscles and tendons eliminating impediment；Clearing away heat and eliminating pus.Main oedema；Tinea pedis；Dribbling urination；Damp-warm diseases； Diarrhea leukorrhagia；Rheumatic arthralgia；Muscle arteries and veins contraction；Pulmonary abscess；Acute appendicitis；Verruca plana.

Rheum officinale, medicinal source are polygonum rheum palmatumRheum palmatum L., Rheum tanguticum MaximRheum tanguticum Maxim.ex Balf. or Rheum officinaleRheum officinaleBaill. drying root and rhizome.Have Attack stagnant, clearing away damp-heat, purging intense heat, cool blood, dissolving stasis, removing toxic substances and other effects.Major function: the logical intestines that purge heat, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow. For real heat constipation, stagnate abdominal pain, and dysentery is not well, jaundice with damp-heat pathogen, blood-head tells nosebleed, hot eyes, pharynx swelling, abdominalgia with intestinal abscess, carbuncle swells furunculosis, Blood stasis closed, traumatic injury, scald；Upper gastrointestinal bleeding.Rheum palmatum (processed with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.

According to Chinese medicine viewpoint, the main muscle of skin, lung associating with skin and hair, patients with acne innate excess of YANG in the body, lung channel intrinsic heat, damp and hot rich knot, skin Rouge secretion metabolism is not normal, on smoke and send out this disease in face, select fritillaria, radix scutellariae, the heat of gypsum, the clearing lung-heat stomach such as campanulaceae, gardenia florida, The clear part of the body cavity above the diaphragm housing the heart and lungs such as wild chrysanthemum, Fructus Forsythiae and Zhu Jing are damp and hot, Antilipemic haw, seed of jog's tears invigorating spleen to remove dampness, pollen pini, root of Dahurain angelica apocenosis removing toxic substances of analgesia, rheum officinale Expel the heat-evil defaecation, Radix Glycyrrhizae coordinating the drug actions of a prescription, in addition soak affected part, through skin absorb directly through acting at disease, it is inside and outside have an effect it is quick.

Technical solution provided in an embodiment of the present invention has the benefit that

1, the Oral preparation of Chinese medicine composition provided in an embodiment of the present invention and external application lotion are made of same Chinese medicine substantially, Preparation is easy, and is suitable for home use.

2, Chinese medicine composition provided in an embodiment of the present invention has good clinical efficacy to homeliness type acne, and effective percentage reaches 85%。

3, one auxiliary of Chinese medicine composition provided in an embodiment of the present invention realizes external application and interior use simultaneously, and action speed is fast.

4, Chinese medicine composition provided in an embodiment of the present invention has many advantages, such as that treatment cycle is short, uneasy to recur.

Specific embodiment

To make the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention will be made into one below Step ground detailed description.

Embodiment 1-6 provides the specific formula of the Chinese medicine composition for treating homeliness type acne, specifically such as 1 institute of table Show:

Table 1

Preparation method are as follows:

(1) preparation of Oral preparation: take according to the ratio fritillaria, radix scutellariae, hawthorn, wild chrysanthemum, Fructus Forsythiae, campanulaceae, gypsum, Radix Glycyrrhizae, Pollen pini, the root of Dahurain angelica, gardenia florida and the seed of jog's tears, with decocting 3 times, each decoction is with 10 times that water is raw material weight, mistake after the completion of decoction Filter, decoction liquor is spare, and filter residue is decocted next time, merges decoction liquor and obtains Oral preparation.

(2) it is applied with the preparation of lotion: according to the ratio boiling decoction residue and rheum officinale that step (1) obtains altogether with water 1 time, decoct With 6 times that water is raw material weight, filter, it is so cooling that be applied with lotion.

Clinical example

1 zoopery of test example (drug paraxylene causes mouse ear swelling experiment)

1.1, ICR system mouse 50, male female fifty-fifty, the total 19-24g of body is purchased from Hua Zhong Agriculture University's Life Science and Technology Institute.

1.2, reagent dimethylbenzene: the 9066th plant produced of the Chinese People's Liberation Army.

1.3, drug: lotion obtained by the embodiment of the present invention 3.The washing lotion of the embodiment of the present invention 3 is made into matrix respectively Low concentration (twice of dilution), middle concentration (stoste), the washing lotion of high concentration (twice of concentration), are separately diluted to 30% medicine with distilled water Liquid, it is spare.Comparison medicine: adapalene gel, 10g dress.

1.4 instrument micrometer calipers, 6mm punch, 12mm punch.

ICR system mouse 50 is only randomly divided into 5 groups, and every group 10, half male and half female.Medication group is washed with basic, normal, high concentration respectively Liquid 0.5g is applied to two auricular concha two sides of mouse, model group external application 0.5g physiological saline, and control group applies adapalene gel outside, daily Coating 3 times, each dosage is about 1 gram/cm, for three days on end.The 1h after last coating, by dimethylbenzene 0.03ml drop in small The cause of mouse auris dextra shell two sides is scorching, after 3h, mouse is dislocated and is put to death, removes circle at the symmetrical place of left and right ear respectively with diameter 6mm punch Shape auricle, assay balance weighing.The of poor quality of ears is swelling, and data are as shown in table 2.

Table 2

In table 2, drug of the present invention tries 3 concentration group mouse auricular concha swellings and is below model group, shows medicine of the present invention Object paraxylene causes chmice acute ear swelling to have inhibiting effect, i.e., drug of the invention has certain effect to inflammation tool.

Bacteriostasis of the drug of the present invention of test example 2 to common bacterial strain

Solid process antibacterial action: it is intensively lined on blood ware or common plate with various test organisms, is beaten with 8mm punch Hole, every hole are added sterile reagent medicine about 0.2mL, cultivate 18-24 hours at 37 DEG C, the size of inhibition zone is observed, with of the invention For lotion, judge that the results are shown in Table 3 for its sensitivity.

Table 3

In table 3: antibacterial circle diameter < 9mm, anti-medicine-；Antibacterial circle diameter 9-14mm(does not include 14mm), slight sensitive+；Suppression Bacterium loop diameter 14-19mm(does not include 19mm), medium sensitivity ++；Antibacterial circle diameter 20-29mm(does not include 29mm), it is highly sensitive +++.Wherein, the specific source of three concentration groups causes mouse ear swelling experiment referring to drug paraxylene.It can from table 3 Lotion of the invention has certain inhibiting effect to the bacterium for causing acne out.

The clinical drug trial of the invention of test example 3

1, case statistics: case is selected from Hubei Province, takes the principle of voluntariness, number 150；Wherein, male 81, female 69 Example, the age 15-35 years old, average age 21.3 years old, predominantly student enrollment.Mean random is divided into five groups, and 60 people of control group controls The statistical distribution of 90 people for the treatment of group, control group and treatment group is similar；Wherein, experimental group 1,2 and 3 using the embodiment of the present invention 2, 3 and 5 Oral preparation and external application lotion, 7 days as one therapeutic course treats 3 courses for the treatment of, carries out follow-up after being discontinued three months；1 mouthful of control group Tetracycline 250mg is taken, 3 times a day, vitamin B6 10mg is used 3 weeks 3 times a day.Control group 2 is using outside adapalene gel It applies, 2 times a day, outer painting amount is determined according to affected part size, is used 3 weeks.

2, medicine preparation: Oral preparation is prepared by the formula of embodiment, 3 and 5 and is applied with lotion.

3, drug application method: daily one is secondary, takes for decocting 3 times, rear to decoct 1 washout and cold compress affected part.It is treated for one within 7 days Journey, continuous 3 courses for the treatment of.

4, diagnostic criteria: (1) according to " Surgery of Chinese Medicine " parting standard, belonging to lung meridian wind-heat type person, symptoms include: papule color is red, Or have pain of itching, or have warts, with thirst and liking drink, constipation, scanty drak urine, red tongue body, moss thin yellow, wiry and rolling pulse；Belong to damp and hot to accumulate Junction type person, symptoms include: facial skin is greasy, and fash is shown in inflamed papules, purulence papule, warts, tubercle etc., with halitosis, constipation, yellow urine Deng, red tongue body, yellow and greasy fur, slippery and rapid pulse；(2) male, female volunteer；(3) into testing, oral in 2 weeks or external application is other is controlled Treat acne drug person；(4) reject standard: during treatment while the other Retinoids, Retin-A, Renova, Accutane persons of oral administration and externally, or appearance are obviously drawn The case where sending out homeliness type acne situation fails to complete course for the treatment of person.

5, criterion of cure: referring to Chinese medical aesthetics and cosmetology branch beautifying skin group: acne vulgaris classification and treatment Criterion quasi- preliminary formulation (Chinese medical beauty magazine, 1998,4 (1): 41).

(1) grade scale (3 degree of 9 grades of classification): it is divided into 3 degree 9 grades according to symptom.

(2) standards of grading: first 3 degree 9 grades for the treatment of, every 1 grade is chosen as 1 point；After treatment, every 1 grade of reduction subtracts 1 point, if all Disappear then is 0 point；Therapeutic index=(score after score-treatment before treating)/index × 100% before treating.

(3) criterion of therapeutical effect: it is divided into 4 grades.The above are clinical cures up to 95% for therapeutic index；Therapeutic index 60-95% is effective； Therapeutic index 20-59% is effective；Therapeutic index < 20% is invalid.

6, treatment results: according to clinical symptoms, after three weeks using drug of the invention, 21 is cured, accounts for 23.3%；It is effective 35, account for 38.9%；Effective 21, account for 23.3%%；Invalid 13, account for 14.4%；Total effective rate 85.6%, to 1-3 grades of symptom effects Preferably, healing time is short, and average onset time is 10.7 days.In addition, control group 1, total effective rate 76.7%, healing time is long； Control group 2, total effective rate 80%, healing time is longer.But according to return visit (in March), the recurrence rate for the treatment of group is 26.7%, the recurrence rate of control group 1 is 30%, and the high recurrence rate of control group 2 is up to 35%, i.e., uneasy to recur using this drug.Treatment system Result is counted as shown in table 4-7.

Table 4

Wherein, table 4 is therapeutic effect statistical result, from table 4, it can be seen that the present invention provides in three treatment cycles Medication effect it is preferable.

Table 5

Wherein, table 5 is therapeutic effect of this drug to treatment group's various symptoms, as can be seen from Table 5, provided by the invention Drug is preferable to 1-3 grades of symptom effects.

Table 6

Processing	Shortest time	Maximum duration	Average time
				Treatment 1	9	14	12.5
Treatment 2	7	11	9.4
				Treatment 3	8	12	10.3
Control 1	14	21	16.7
				Control 2	9	16	13.2

Wherein, table 6 is onset time statistical result (unit is day), and as can be seen from Table 6, drug provided by the invention is shown in Effect is fast.Control group 1 continues to use, and also has patient to take effect successively.

Table 7

Processing	Number of cases	Recur number of cases	Number of cases is not recurred	Recurrence rate
					Treatment 1	20	5	15	25.0%
Treatment 2	20	5	15	25.0%
					Treatment 3	20	6	14	30.0%
Control 1	20	6	14	30.0%
					Control 2	20	7	13	35.0%

Wherein, table 7 is recurrence rate statistical result, and as can be seen from Table 7, the curative effect of drug provided by the invention is not easy Recurrence.

Specific clinical case:

Implement 1: Lee, male, 23 years old, people from Huang gang, white collar, forehead and back were throughout slight whelk.Using of the invention After two courses for the treatment of of drug, acne point redness disappears.

Implementation 2: Wu, male, 18 years old, people from Ezhou, students, patient's homeliness type acne history 2 years, face acnes when going to a doctor For furuncle sample, cheek and skin of jaw many places are red and swollen, there is purulence head, are mixed with multiple acne distributions.Using of the invention drug 5 days, Acne starts to mitigate, and redness gradually changes；After continuing medication 7 days, acne is substantially eliminated on the face, and only there are slight red traces；Again To consolidate curative effect, recurrence is not shown in recovery from illness, rear follow-up within following the service 3 days.

Implementation 3: Gong, female, 19 years old, people from Huang gang, students.There is a large amount of whelks medical early period, continuous 3 weeks Fail voluntarily to subside.Using of the invention drug 7 days, facial small pox started to be obviously reduced, and continued medication to 14 days, small pox is opened Beginning wilts, red seal starts to subside, and continues medication to 21 days, and facial whelk is all eliminated, and rebound phenomenon not yet occurs in rear follow-up.

Implementation 4: Zhang, female, 18 years old, people from Wuhan, students.Forehead, cheek have red and swollen acne, there is scleroma.Use this After the drug 7 of invention, the disappearance of cheek acne point is more, and forehead is slightly reduced.After continuing to use 5 days, acne no longer increases, original acne Become listless, redness subsides.

Implement 5: it is virgin certain: female, 22 years old, people from Huang gang, shop-assistant saw that forehead, nose cheek, face are outstanding in cone when medical There is the grain of rice, the papule of mung bean sample, warts, be in Whiteheads.Medical history is up to 4 years as long as.Behind drug 10 days in the present invention, Whelk, acne start to wilt and subside, and after continuing medication 10 days, facial small pox is substantially eliminated, recovery from illness.

The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.

Claims (3)

1. a kind of for treating the Chinese medicine composition of homeliness type acne, which is characterized in that including Oral preparation and be applied with lotion；

The Oral preparation is decocted by following raw material: fritillaria 7-13 parts by weight, radix scutellariae 9-20 parts by weight, hawthorn 22-40 weight Part, wild chrysanthemum 4-15 parts by weight, Fructus Forsythiae 10-24 parts by weight, campanulaceae 10-25 parts by weight, gypsum 15-35 parts by weight, Radix Glycyrrhizae 6- 15 parts by weight, pollen pini 6-15 parts by weight, root of Dahurain angelica 5-17 parts by weight, gardenia florida 5-15 parts by weight, seed of jog's tears 12-30 parts by weight；

The lotion that is applied with is as preparing washing lotion made of the residue after Oral preparation decocts boils altogether with 4-15 parts by weight rheum officinale；

Preparation method are as follows:

(1) preparation of Oral preparation: fritillaria, radix scutellariae, hawthorn, wild chrysanthemum, Fructus Forsythiae, campanulaceae, gypsum, Radix Glycyrrhizae, preserved egg are taken according to the ratio Powder, the root of Dahurain angelica, gardenia florida and the seed of jog's tears are merged decoction liquor and obtain Oral preparation, each decoction is raw material weight with water with decocting 2-3 times 8-15 times；

(2) it is applied with the preparation of lotion: according to the ratio boiling decoction residue and rheum officinale that step (1) obtains altogether 1 time, filter, cooling It is applied with lotion, decoction 5-8 times that water is raw material weight.

2. according to claim 1 for treating the Chinese medicine composition of homeliness type acne, which is characterized in that the Oral preparation It is decocted by following raw material: fritillaria 8-10 parts by weight, radix scutellariae 12-16 parts by weight, hawthorn 25-35 parts by weight, wild chrysanthemum 7-12 Parts by weight, Fructus Forsythiae 10-20 parts by weight, campanulaceae 15-20 parts by weight, gypsum 20-28 parts by weight, Radix Glycyrrhizae 8-13 parts by weight, preserved egg Powder 8-10 parts by weight, root of Dahurain angelica 7-12 parts by weight, gardenia florida 10-12 parts by weight, seed of jog's tears 16-25 parts by weight；

The lotion that is applied with is as preparing washing lotion made of the residue after Oral preparation decocts boils altogether with 5-10 parts by weight rheum officinale.

3. according to claim 1 for treating the Chinese medicine composition of homeliness type acne, which is characterized in that the Oral preparation Composition in parts by weight are as follows: 10 parts by weight of fritillaria, 15 parts by weight of radix scutellariae, 30 parts by weight of hawthorn, 10 parts by weight of wild chrysanthemum, Fructus Forsythiae 15 parts by weight, 15 parts by weight of campanulaceae, 25 parts by weight of gypsum, 10 parts by weight of Radix Glycyrrhizae, 10 parts by weight of pollen pini, 10 weight of the root of Dahurain angelica Part, 10 parts by weight of gardenia florida, 20 parts by weight of the seed of jog's tears；

It is described be applied with lotion be as prepare Oral preparation decoct after residue and 8 parts by weight rheum officinales boil altogether made of washing lotion.