CN110051761A - Topical agent of acne-removing inflammation-diminishing and preparation method thereof - Google Patents
Topical agent of acne-removing inflammation-diminishing and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of Chinese medicines, and in particular to a kind of topical agent of acne-removing inflammation-diminishing and preparation method thereof.Including following traditional Chinese medicinal components: allantoin glycerol, propylene glycol, ethylhexyl palmitate, tristerin/PEG-100 stearate, cetearyl glucoside, dimethyl silicone polymer, ring five dimethyl silicone polymer, cetostearyl alcohol, caprylic/capric triglyceride, xanthan gum, Sodium Hyaluronate, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, PEG-7 trihydroxy methyl propyl cocounut oil ether, Ganodernaa lucidum extract, shrubby sophora extract, Salvia root P.E, glossy privet fruit extract, the bark of official magnolia bark extract, gadol extract, radix-polygoni multiflori extract, spikemoss extract, Fructus Gleditsiae Abnormalis extract, aloe vera extract etc..The present invention can not only effectively treat all types of small poxs, acne, eczema, dermatitis, and treatment cycle is short, quick, Small side effects, be not easy recurrent exerbation, not stay acne print, acne scar etc..
Description
Technical field
The invention belongs to the field of Chinese medicines, and in particular to a kind of topical agent of acne-removing inflammation-diminishing and preparation method thereof.
Background technique
" whelk " is patient facial region's pilosebaceous follicle chronic inflammation disease, is one of most common disease of dermatology.
" whelk " develops as one pleases if effective treatment not in time and just will affect the appearance of patient.Its fall ill mainly with sex hormone water
Flat, sebaceous glands is largely secreted, propionibacterium acnes are proliferated, and the factors such as dyskeratosis and inflammation of pilosebaceous duct are related.
Eczema is a kind of scytitis reaction of the acute pruritus as caused by a variety of internal and external factors.Principal pathogenetic reason is
Many factors cause T lymphocyte contact allergy former and type Ⅳ allergy occur, and acute eczema can recurrent exerbation, it is difficult to control
More, if will seriously affect minimal invasive treatment and work to acute eczema without timely treating and controlling.
Dermatitis refers to that one of the dermal inflammatory illness as caused by various inside and outside portion's infection or non-infectious factor is general
Claim, the cause of disease and complicated clinical manifestation multiplicity, such as contact sensitization, skin infection.Clinically often according to the cause of disease, site of pathological change
Or a certain specific dermatitis is defined as so-and-so dermatitis by other Clinical symptoms, is known as contact skin as caused by contact something
Inflammation, innerlich anwenden object is caused to be known as deramatitis medicamentosa etc..
Small pox, acne, eczema, dermatitis etc. may cause scar without treatment or treatment not in time, seriously affect patient
Quality of life, cause stress and the financial burden of patient, need to cause to pay close attention to.That there are service life is long for traditional product, sees
The problems such as effect is slow, and side effect is big, recurrent exerbation, easily stays acne print, acne scar.
Summary of the invention
In view of the deficiencies of the prior art, the object of the present invention is to provide a kind of topical agents of acne-removing inflammation-diminishing, can not only have
All types of small poxs, acne, eczema, dermatitis are treated in effect ground, and treatment cycle is short, and quick, Small side effects are not easy recurrent exerbation,
Acne print, acne scar etc. are not stayed.
The topical agent of acne-removing inflammation-diminishing of the present invention, the component including following parts by weight:
20-30 parts of deionized water, 8-10 parts of allantoin glycerol, 45-50 parts of propylene glycol, 45-50 parts of ethylhexyl palmitate,
Tristerin/8-10 parts of PEG-100 stearate, 4.5-5 parts of cetearyl glucoside, dimethyl silicone polymer 18-
20 parts, 45-50 parts of ring five dimethyl silicone polymer, 90-100 parts of cetostearyl alcohol, 9-10 parts of atoleine, caprylic/capric are sweet
Oily 18-20 parts of three ester, 9-10 parts of xanthan gum, 18-20 parts of Sodium Hyaluronate, hydroxy-ethyl acrylate/acryloyldimethyl taurine
28-30 parts of sodium copolymer, 18-20 parts of polyisobutene, 45-50 parts of PEG-7 trihydroxy methyl propyl cocounut oil ether, Ganodernaa lucidum extract 180-
200 parts, 90-100 parts of shrubby sophora extract, 90-100 parts of Salvia root P.E, 90-100 parts of glossy privet fruit extract, Magnolia bark extraction
90-100 parts of object, 90-100 parts of gadol extract, 90-100 parts of radix-polygoni multiflori extract, 90-100 parts of spikemoss extract, gleditsia sinensis
90-100 parts of extract, 180-200 parts of aloe vera extract, 9-10 parts of auxiliary agent, 9-10 parts of essence.
As a kind of perferred technical scheme, the component including following parts by weight:
20 parts of deionized water, 10 parts of allantoin glycerol, 50 parts of propylene glycol, 50 parts of ethylhexyl palmitate, glycerol stearate
Ester/10 parts of PEG-100 stearate, 5 parts of cetearyl glucoside, 20 parts of dimethyl silicone polymer, five poly dimethyl silicon of ring
50 parts of oxygen alkane, 100 parts of cetostearyl alcohol, 10 parts of atoleine, 20 parts of caprylic/capric triglyceride, 10 parts of xanthan gum, hyalomitome
20 parts of sour sodium, 30 parts of hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, 20 parts of polyisobutene, tri- hydroxyl first of PEG-7
50 parts of base propyl cocounut oil ether, 200 parts of Ganodernaa lucidum extract, 100 parts of shrubby sophora extract, 100 parts of Salvia root P.E, glossy privet fruit extract
100 parts, 100 parts of the bark of official magnolia bark extract, 100 parts of gadol extract, 100 parts of radix-polygoni multiflori extract, spikemoss extract 100
Part, 100 parts of Fructus Gleditsiae Abnormalis extract, 200 parts of aloe vera extract, 10 parts of auxiliary agent, 10 parts of essence.
Wherein:
Allantoin is not easily dissolved, and allantoin is first put into the glycerol for being heated to 45-50 degrees Celsius by the application, stirring
It obtains allantoin glycerol within 15-20 minutes, makes it easier to be dissolved in other substances.
It is original that tristerin/PEG-100 stearate, which is by polyoxyethylene stearic acid ester and glycerin monostearate,
Expect the food emulsifying agent of production.
Auxiliary agent is Phenoxyethanol, methyl hydroxybenzoate, Nipasol, ethylhexyl glycerol are 2:1:1:3 mixing by weight.
The preparation method of the topical agent of acne-removing inflammation-diminishing of the present invention, comprising the following steps:
(1) raw material needed for precise；
(2) deionized water, allantoin glycerol, propylene glycol, ethylhexyl palmitate, tristerin/PEG-100 is hard
Resin acid ester, cetearyl glucoside are thrown in reaction pot, and agitating and heating is warming up to 90 ± 2 DEG C, stirring heat preservation, until completely
It is dissolved into pellucidity, obtains reactant；
(3) by dimethyl silicone polymer, ring five dimethyl silicone polymer, cetostearyl alcohol, atoleine, caprylic/capric
Triglycerides, xanthan gum, Sodium Hyaluronate, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, polyisobutene,
PEG-7 trihydroxy methyl propyl cocounut oil ether, auxiliary agent, essence are thrown in reaction pot, reaction pot are heated to 85 ± 2 DEG C, stirring is protected
Temperature obtains reactant until being completely dissolved in pellucidity；
(4) reactant obtained in step (3) reaction pot is pumped into the reaction pot in step (2), is stirred under vacuum equal
Then matter stirs heat preservation under 80 DEG C~85 DEG C of temperature environment, obtains reactant；
(5) by Ganodernaa lucidum extract, shrubby sophora extract, Salvia root P.E, glossy privet fruit extract, the bark of official magnolia bark extract, red
Red-spotted stonecrop extract, radix-polygoni multiflori extract, spikemoss extract, Fructus Gleditsiae Abnormalis extract and aloe vera extract are put into mixing in casserole
It 40-45 minutes, is heated slowly with native furnace firewood mild fire；
(6) reactant that step (5) obtains is added in the reactant that step (4) obtains, is stirred under vacuum homogeneous, then
Heat preservation is stirred under 50-55 DEG C of temperature environment, is then down to room temperature and is obtained product.
Wherein:
It is 20-25 minutes that step (2), which stirs soaking time,；It is 12-15 minutes that step (3), which stirs soaking time,；Step (4)
Stirring soaking time is 20-22 minutes；It is 10-12 minutes that step (6), which stirs soaking time,.
It is 7-8 minutes that the time is pumped into step (4).
It is stirred under vacuum homogeneous 6-7 minutes in step (4).
Drug action mechanism in the present invention is as follows:
Red sesame: nature and flavor, hardship, flat, nontoxic, channel tropism: conscience, lung channel, major function: the gain motive, supplement internal organ, growth intelligence
Intelligent, enhancing memory.
Kuh-seng: nature and flavor bitter, it is cold in nature；Channel tropism: return heart, liver, stomach, large intestine, bladder meridian；Effect: heat-clearing and damp-drying drug, desinsection, benefit
Urine；The major functions: it is used for hot dysentery, and hematochezia, jaundice urodialysis, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae, eczema, wet sore, pruitus, castor,
Trichomonas vaginitis is controlled outside.
Radix Salviae Miltiorrhizae: nature and flavor bitter, it is slightly cold；Channel tropism: converge to heart and liver channels；Effect: promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness and restlessness are cool
Blood disappears carbuncle；The major functions: being used for chest impediment and cardialgia, stomach duct and abdomen hypochondriac pain, a lump in the abdomen causing distension and pain, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhea warp
It closes, sore swell and ache curative.
The fruit of glossy privet: nature and flavor, are put down at bitter sweet；Channel tropism: liver, spleen, lung, warp；Major function: nourishing liver and kidney, strong waist and knee.It controls in the deficiency of Yin
Heat, dizzy, mesh flower, tinnitus, soreness and weakness of waist and knees, poliosis.It is nourishing liver and kidney, improving eyesight black hair.For dizziness and tinnitus, soreness and weakness of waist and knees,
Poliosis, mesh are secretly unknown.
Cortex Magnoliae Officinalis: nature and flavor, hardship, pungent, warm-natured；Channel tropism: the spleen channel, stomach meridian, large intestine channel；Function: gas consumption product, eliminating dampness except full, drop
It is inverse to relieving asthma.The major functions: stagnation of QI due to dyspepsia；Abdominal distention constipation, damp retention in middle-jiao, abdominal swelling and diarrhea, phlegm stops up the circulation of vital energy in the wrong direction, chest full of cough.
Root of kirilow rhodiola: nature and flavor: cold, sweet, puckery；Major function: having tonifying Qi clearing lung-heat, intelligence development nourishing heart, controlling of bleeding with astringents, eliminating stasis to subdue swelling
Effect.Cure mainly deficiency of vital energy and physically weak, after being ill chilly, shortness of breath and fatigue, cough with lung heat, hemoptysis, leukorrhea diarrhea, traumatic injury etc..
The fleece-flower root: nature and flavor: bitter；It is sweet；It is puckery；Slightly warm in nature；Channel tropism: liver and kidney channel；Major function: nourishing the blood and yin；Relax bowel and defecation；
Preventing malaria；Wind-dispelling；Removing toxic substances.Main deficiency of blood Light-headedness；Palpitaition；Insomnia；The soreness and weakness of waist and knees of the deficiency of liver-yin and kidney-yin；Poliosis；Tinnitus；It loses
Essence；Dry constipation of intestines；Chronic malaria body void；Rubella itch；Sore carbuncle；Scrofula；Hemorrhoid.External application: it is appropriate, washing is decocted, grinds and spreads or adjust painting.
Selaginella tamariscina: nature and flavor acrid flavour, it is mild-natured；Channel tropism: return liver, the heart channel of Hang-Shaoyin；Effect: Selaginella tamariscina blood circulation；Selaginella tamariscina charcoal removing blood stasis and hemostasis；It is main
Control: Selaginella tamariscina is used for amenorrhea and algomenorrhea, lump in the abdomen lump in the abdomen lump in the abdomen, injury from falling down.
Gleditsia sinensis: meridian distribution of property and flavor is warm-natured, acrid flavour, salty.It is slightly poisonous.Distributed in lung channel, large intestine channel.Effect and effect: eliminating the phlegm of having one's ideas straightened out dissipates
Knot detumescence, moistening dryness for relaxing bowels.With control apoplexy lockjaw, remain unconscious, epilepsy phlegm is contained, closes that key is obstructed, the resistance of sore throat phlegm, chronic phlegm are not well, big
Just constipation；Controlling outward carbuncle swells.
Aloe barbadensis Miller: curing mainly constipation with heat retention, women's menostasis, and children are dried in the air epilepsy, infantile malnutrition with fever malnutrition due to parasitic infestation, tinea sore, hemorrhoid complicated by anal fistula, atrophic nose
Inflammation, scrofula.
Above all medicines cure mainly and effect is referred to the college of traditional Chinese medicine undergraduate course teaching material " Chinese pharmacology " sixth version, Science and Technology of Shanghai goes out
Version society.
The present invention cooperates aloe vera extract, thickness using propylene glycol, allantoin glycerol, caprylic/capric triglyceride
Hackberry bark extract etc. carries out natural moisturizing factor exogenous supplement to skin, reduces moisture loss；Using Sodium Hyaluronate, whale
Wax stearyl glucoside, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, Ganodernaa lucidum extract, shrubby sophora extract,
Salvia root P.E, glossy privet fruit extract, gadol extract etc. promote skin metabolism, other than crease-resistant, moistening effect, also
Have the function of scavenging activated oxygen, can promote the regeneration of injury skin；Tristerin/PEG- that the present invention uses
100 stearates, PEG-7 trihydroxy methyl propyl cocounut oil ether etc. protect horn cell, consolidate skin, protected protein matter.
The following are clinical test summaries:
Usage and dosage: the product that the present invention obtains is paste, can use in the following ways: directly be applied to affected part,
Decoction is placed on milk and fruit syrup embrocates affected part, is immersed in decoction with young leaf of plant piece and is attached to local affected part, be added in facial mask
In base-material, application in warm decoction is placed on towel and gauze and is placed in beeswax on the face and is applied to affected part.One week is a treatment
Journey.
Treatment results:
This prescription treats more than 3000 people altogether, wherein more than 700 people of male, more than 2300 people of women.Wherein 18~30 years old more than 2200
People, 30~55 years old more than 790 people, 55 years old or more more than 10 people.Wherein more than 2700 people of small pox patient, 99% or more cure rate, acne, skin
Scorching more than 300 people of patient, 99% or more cure rate are generally all cured in 1~3 course for the treatment of or so.
By the way that shown in treatment, without any side effects to patient, three big routine tests and liver and kidney function tests are no abnormal
Phenomenon.
Compared with the prior art, the present invention has the following beneficial effects:
(1) Chinese medicine selected of the present invention meets Pharmacopoeia of the People's Republic of China regulation, dialectical accurate, compatibility rationally,
Medication is superior, treating both manifestation and root cause of disease, and quick, short treating period, cure rate are high, have no toxic side effect.
(2) present invention can not only effectively treat all types of small poxs, acne, eczema, dermatitis, and treatment cycle is short, takes effect
Fastly, Small side effects, are not easy recurrent exerbation, do not stay acne print, acne scar etc..
(3) Escherichia coli, staphylococcus aureus are pathogenic bacteria, and Candida albicans is pathomycete, must addiction hair addiction bacterium
It is pathogenic addiction bacterium most common in various skin diseases.Patients' Chang Yin itch such as eczema, dermatitis feels bad and goes to scratching affected part, causes
Skin injury, easy infection bacterium or fungi make that sb.'s illness took a turn for the worse, and product of the present invention is to Escherichia coli, staphylococcus aureus, white
Candida albicans and palpus addiction hair addiction bacterium all have stronger antibacterial action.
Specific embodiment
Below with reference to embodiment, the present invention will be further described.
Embodiment 1
A kind of topical agent of acne-removing inflammation-diminishing, the component including following parts by weight:
20 parts of deionized water, 10 parts of allantoin glycerol, 50 parts of propylene glycol, 50 parts of ethylhexyl palmitate, glycerol stearate
Ester/10 parts of PEG-100 stearate, 5 parts of cetearyl glucoside, 20 parts of dimethyl silicone polymer, five poly dimethyl silicon of ring
50 parts of oxygen alkane, 100 parts of cetostearyl alcohol, 10 parts of atoleine, 20 parts of caprylic/capric triglyceride, 10 parts of xanthan gum, hyalomitome
20 parts of sour sodium, 30 parts of hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, 20 parts of polyisobutene, tri- hydroxyl first of PEG-7
50 parts of base propyl cocounut oil ether, 200 parts of Ganodernaa lucidum extract, 100 parts of shrubby sophora extract, 100 parts of Salvia root P.E, glossy privet fruit extract
100 parts, 100 parts of the bark of official magnolia bark extract, 100 parts of gadol extract, 100 parts of radix-polygoni multiflori extract, spikemoss extract 100
Part, 100 parts of Fructus Gleditsiae Abnormalis extract, 200 parts of aloe vera extract, 10 parts of auxiliary agent, 10 parts of essence.
Allantoin glycerol are as follows: allantoin is put into the glycerol for being heated to 45 degrees Celsius, is stirred 20 minutes.
Auxiliary agent is Phenoxyethanol, methyl hydroxybenzoate, Nipasol, ethylhexyl glycerol are 2:1:1:3 mixing by weight.
The preparation method of the topical agent of acne-removing inflammation-diminishing, comprising the following steps:
(1) raw material needed for precise；
(2) deionized water, allantoin glycerol, propylene glycol, ethylhexyl palmitate, tristerin/PEG-100 is hard
Resin acid ester, cetearyl glucoside are thrown in reaction pot, and agitating and heating is warming up to 90 ± 2 DEG C, and stirring keeps the temperature 22 minutes, directly
To pellucidity is completely dissolved in, reactant is obtained；
(3) by dimethyl silicone polymer, ring five dimethyl silicone polymer, cetostearyl alcohol, atoleine, caprylic/capric
Triglycerides, xanthan gum, Sodium Hyaluronate, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, polyisobutene,
PEG-7 trihydroxy methyl propyl cocounut oil ether, auxiliary agent, essence are thrown in reaction pot, reaction pot are heated to 85 ± 2 DEG C, stirring is protected
Temperature 15 minutes obtains reactant until being completely dissolved in pellucidity；
(4) reactant obtained in step (3) reaction pot is pumped into the reaction pot in step (2), being pumped into the time is 8
Minute, it is stirred under vacuum homogeneous 7 minutes, then stirring heat preservation 22 minutes under 83 DEG C of temperature environment, obtain reactant；
(5) by Ganodernaa lucidum extract, shrubby sophora extract, Salvia root P.E, glossy privet fruit extract, the bark of official magnolia bark extract, red
Red-spotted stonecrop extract, radix-polygoni multiflori extract, spikemoss extract, Fructus Gleditsiae Abnormalis extract and aloe vera extract are put into mixing in casserole
It 40 minutes, is heated slowly with native furnace firewood mild fire；
(6) reactant that step (5) obtains is added in the reactant that step (4) obtains, is stirred under vacuum homogeneous, then
Stirring heat preservation 10 minutes, obtain product under 60 DEG C of temperature environment.
Embodiment 2
A kind of topical agent of acne-removing inflammation-diminishing, the component including following parts by weight:
30 parts of deionized water, 8 parts of allantoin glycerol, 45 parts of propylene glycol, 45 parts of ethylhexyl palmitate, glycerol stearate
Ester/8 parts of PEG-100 stearate, 4.5 parts of cetearyl glucoside, 18 parts of dimethyl silicone polymer, five poly dimethyl silicon of ring
45 parts of oxygen alkane, 90 parts of cetostearyl alcohol, 9 parts of atoleine, 18 parts of caprylic/capric triglyceride, 9 parts of xanthan gum, hyaluronic acid
18 parts of sodium, 28 parts of hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, 18 parts of polyisobutene, PEG-7 trihydroxy methyl
45 parts of propyl cocounut oil ether, 180 parts of Ganodernaa lucidum extract, 90 parts of shrubby sophora extract, 90 parts of Salvia root P.E, glossy privet fruit extract 90
Part, 90 parts of the bark of official magnolia bark extract, 90 parts of gadol extract, 90 parts of radix-polygoni multiflori extract, 90 parts of spikemoss extract, gleditsia sinensis mention
Take 90 parts of object, 180 parts of aloe vera extract, 9 parts of auxiliary agent, 9 parts of essence.
Allantoin glycerol are as follows: allantoin is put into the glycerol for being heated to 50 degrees Celsius, is stirred 16 minutes.
Auxiliary agent is Phenoxyethanol, methyl hydroxybenzoate, Nipasol, ethylhexyl glycerol are 2:1:1:3 mixing by weight.
The preparation method of the topical agent of acne-removing inflammation-diminishing, comprising the following steps:
(1) raw material needed for precise；
(2) deionized water, allantoin glycerol, propylene glycol, ethylhexyl palmitate, tristerin/PEG-100 is hard
Resin acid ester, cetearyl glucoside are thrown in reaction pot, and agitating and heating is warming up to 90 ± 2 DEG C, and stirring keeps the temperature 25 minutes, directly
To pellucidity is completely dissolved in, reactant is obtained；
(3) by dimethyl silicone polymer, ring five dimethyl silicone polymer, cetostearyl alcohol, atoleine, caprylic/capric
Triglycerides, xanthan gum, Sodium Hyaluronate, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, polyisobutene,
PEG-7 trihydroxy methyl propyl cocounut oil ether, auxiliary agent, essence are thrown in reaction pot, reaction pot are heated to 85 ± 2 DEG C, stirring is protected
Temperature 12 minutes obtains reactant until being completely dissolved in pellucidity；
(4) reactant obtained in step (3) reaction pot is pumped into the reaction pot in step (2), being pumped into the time is 7
Minute, it is stirred under vacuum homogeneous 6 minutes, then stirring heat preservation 20 minutes under 80 DEG C of temperature environment, obtain reactant；
(5) by Ganodernaa lucidum extract, shrubby sophora extract, Salvia root P.E, glossy privet fruit extract, the bark of official magnolia bark extract, red
Red-spotted stonecrop extract, radix-polygoni multiflori extract, spikemoss extract, Fructus Gleditsiae Abnormalis extract and aloe vera extract are put into mixing in casserole
It 43 minutes, is heated slowly with native furnace firewood mild fire；
(6) reactant that step (5) obtains is added in the reactant that step (4) obtains, is stirred under vacuum homogeneous, then
Stirring heat preservation 11 minutes, obtain product under 62 DEG C of temperature environment.
One, the medicament that the embodiment of the present invention 1 and 2 is prepared detects, and testing result is as follows:
The medicament testing result that 1 Examples 1 and 2 of table are prepared
Two, bacteriostasis property test is carried out to medicament prepared by the embodiment of the present invention 1 and 2: respectively by Escherichia coli, golden yellow
Staphylococcus, Candida albicans, alpha fungus are mixed with product of the present invention, and fungistatic effect is detected after 24 hours, and embodiment 1 is tried
Test result such as table 2,2 test result of embodiment such as table 3.
Table 2
Table 3
By table 2 and table 3 it can be seen that product of the present invention to Escherichia coli, staphylococcus aureus, Candida albicans and
Palpus addiction hair addiction bacterium all has stronger antibacterial action.
Three, moisture of skin is tested
Test crowd: gender is random, and the age is random, and totally 20.
Test zone: cheek.
Test equipment: skin moisture content tester: German CK company skin moisture test probe CM825.
Subject 24 hours before testing, any skin care item and cosmetics were not used in recipient site.In test, subject
Recipient site is cleaned using clear water under staff's guidance, production prepared by the embodiment of the present invention 1 is smeared after half an hour
Product test skin surface water loss.As a result test result such as table 4 passes through the humidity measurements (Moisture of setting
Measurement Value, MMV) it indicates.
Table 4
| Serial number | Time | MMV (average value) |
| 1 | Before test | 35% |
| 2 | 30min | 68% |
| 3 | 60min | 60% |
| 4 | 120min | 55% |
| 5 | 240min | 47% |
Product of the present invention has good moisturizing effects as can be seen from Table 4.
Four, several typical cases are exemplified below:
Case 1:
Liu: female, 22 years old, Minquan County Liu Cun, endocrine disorder was got angry acne.
Nearest 2 years of Liu long acne repeatedly, often stays up late at night, likes blocked shot, so small pox is not gone down always, also become
It obtains not only big but also hard.Various product for resolving poxes were used, effect is all undesirable, and small pox is also more and more.Especially there are also mouths for forehead
Acne is always played around bar.After product of the present invention, small pox is clearly better.At night face wash clean, with cotton swab point at small pox
Product of the present invention is applied, is just softened to the next morning small pox.Adhere to smearing primary, small pox color change after general three days morning again
It is light, it has smeared a course for the treatment of and has just disappeared.
Mr. Wang, female, 23 years old, Zhumadian prefecture, Henan province city, the village He Zhuan, Miyang County, the university student just to have graduated belonged to sensitive flesh
Property.
Never long small pox before, just association's makeup less pay attention to skin care, are all usually to paint adornment not remove ornaments and formal dress, directly use
Facial cleanser is washed off, and sometimes can also be stayed overnight with adornment, and often stay up late.Last year starts to grow Whiteheads on the face, first uses Aloe Vera Gel
It applies, but soon long more of small pox.The clear acne in beauty parlor is gone, it is ineffective.On forehead, the upper and lower Ba Doukai of two cheeks
Begin long small pox.Common product for resolving poxes is smeared, does not apply as long as starting to take a favorable turn and starts to grow, the fall fire for also buying honeysuckle tea etc produces
Product are not effective.Product of the present invention is smeared, using being improved after two courses for the treatment of, small pox on the face all disappears down, only remaining
Some acne prints.After being finished three courses for the treatment of, small pox is completely good on the face, and does not have recurrent exerbation.
Huang, female, 23 years old, the Zhongyuan District village Zhu Tun, closed comedones caused by endocrine disorder, clogging of pores.
There are closed comedones caused by endocrine disorder, clogging of pores totally 1 to 2017 since 2016 in Huang
Year, the People's Hospital, the city Qu Guo, institute of traditional Chinese medicine etc., the methods of used poison expelling capsule, Pimple removing scream and recur slow effect repeatedly.
Product of the present invention, from second course for the treatment of it is seen that small pox is significantly reduced, acne print base after three to five courses for the treatment of are used later
This disappearance, six courses for the treatment of are completely recovered.
Guo so-and-so, female, 21 years old, Baofeng County dragon's fountain village, the blocking of sebaceous gland duct and pore caused whelk.
So-and-so is a sophomore to Guo, begins to long small pox on the face from senior middle school, is perplexed always, and used various anti-acnes produce
Product, effect are little.Later, morning and evening each Tu Yici product of the present invention after my daily face cleaning, when using two courses for the treatment of, those
The small pox to stick out is deflated, in addition being usually careful in one's diet, does not eat pungent stimulation food, notices that daily life is rested, three courses for the treatment of
Small pox disappears substantially on the face afterwards, then repairs acne print acne hole, and six courses for the treatment of are just fully recovered.
Zhao, female, 27 years old, Zhoukou City people from Huaiyang County, endocrine disorder was stayed up late long acne.
Skin bottom is poor, Oily, like it is fuel-displaced, often overtime work stay up late, be negligent of the maintenance to skin, on the face small small pox compared with
It is more, the Chinese medicine of several courses for the treatment of has been drunk, various product for resolving poxes are also attempted, ineffective, the length of small pox still repeatedly, face also becomes dark
It is yellow.After one course for the treatment of of product of the present invention, small pox obviously disappears down, and acne print also shoals after three courses for the treatment of, six courses for the treatment of
Afterwards substantially without acne print, skin is also white very much.
Claims (9)
1. a kind of topical agent of acne-removing inflammation-diminishing, it is characterised in that: the component including following parts by weight:
20-30 parts of deionized water, 8-10 parts of allantoin glycerol, 45-50 parts of propylene glycol, 45-50 parts of ethylhexyl palmitate, tristearin
Acid glyceride/8-10 parts of PEG-100 stearate, 4.5-5 parts of cetearyl glucoside, 18-20 parts of dimethyl silicone polymer,
45-50 parts of ring five dimethyl silicone polymer, 90-100 parts of cetostearyl alcohol, 9-10 parts of atoleine, caprylic/capric triglyceride
18-20 parts, 9-10 parts of xanthan gum, 18-20 parts of Sodium Hyaluronate, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymerization
28-30 parts of object, 18-20 parts of polyisobutene, 45-50 parts of PEG-7 trihydroxy methyl propyl cocounut oil ether, 180-200 parts of Ganodernaa lucidum extract,
90-100 parts of shrubby sophora extract, 90-100 parts of Salvia root P.E, 90-100 parts of glossy privet fruit extract, the bark of official magnolia bark extract 90-
100 parts, 90-100 parts of gadol extract, 90-100 parts of radix-polygoni multiflori extract, 90-100 parts of spikemoss extract, Fructus Gleditsiae Abnormalis extract
90-100 parts, 180-200 parts of aloe vera extract, 9-10 parts of auxiliary agent, 9-10 parts of essence.
2. the topical agent of acne-removing inflammation-diminishing according to claim 1, it is characterised in that: the group including following parts by weight
Point:
20 parts of deionized water, 10 parts of allantoin glycerol, 50 parts of propylene glycol, 50 parts of ethylhexyl palmitate, tristerin/
10 parts of PEG-100 stearate, 5 parts of cetearyl glucoside, 20 parts of dimethyl silicone polymer, ring five dimethyl silicone polymer
50 parts, 100 parts of cetostearyl alcohol, 10 parts of atoleine, 20 parts of caprylic/capric triglyceride, 10 parts of xanthan gum, Sodium Hyaluronate
20 parts, 30 parts of hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, 20 parts of polyisobutene, PEG-7 trihydroxy methyl third
50 parts of base cocounut oil ether, 200 parts of Ganodernaa lucidum extract, 100 parts of shrubby sophora extract, 100 parts of Salvia root P.E, glossy privet fruit extract 100
Part, 100 parts of the bark of official magnolia bark extract, 100 parts of gadol extract, 100 parts of radix-polygoni multiflori extract, 100 parts of spikemoss extract, soap
100 parts of horn extraction, 200 parts of aloe vera extract, 10 parts of auxiliary agent, 10 parts of essence.
3. the topical agent of acne-removing inflammation-diminishing according to claim 1 or 2, it is characterised in that: allantoin glycerol are as follows: by allantois
Element is put into the glycerol for being heated to 45-50 degrees Celsius, is stirred 15-20 minutes.
4. the topical agent of acne-removing inflammation-diminishing according to claim 1 or 2, it is characterised in that: tristerin/PEG-
100 stearates are the food emulsifying agents by polyoxyethylene stearic acid ester and glycerin monostearate for raw material production.
5. the topical agent of acne-removing inflammation-diminishing according to claim 1 or 2, it is characterised in that: auxiliary agent is Phenoxyethanol, oxybenzene
Methyl esters, Nipasol, ethylhexyl glycerol are 2:1:1:3 mixing by weight.
6. a kind of preparation method of the topical agent of acne-removing inflammation-diminishing of any of claims 1 or 2, it is characterised in that: including following
Step:
(1) raw material needed for precise；
(2) by deionized water, allantoin glycerol, propylene glycol, ethylhexyl palmitate, tristerin/PEG-100 stearic acid
Ester, cetearyl glucoside are thrown in reaction pot, and agitating and heating is warming up to 90 ± 2 DEG C, stirring heat preservation, until being completely dissolved
To pellucidity, reactant is obtained；
(3) by dimethyl silicone polymer, ring five dimethyl silicone polymer, cetostearyl alcohol, atoleine, caprylic/capric glycerol
Three esters, xanthan gum, Sodium Hyaluronate, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, polyisobutene, PEG-7
Trihydroxy methyl propyl cocounut oil ether, auxiliary agent, essence are thrown in reaction pot, reaction pot are heated to 85 ± 2 DEG C, stirring is kept the temperature, directly
To pellucidity is completely dissolved in, reactant is obtained；
(4) reactant obtained in step (3) reaction pot is pumped into the reaction pot in step (2), is stirred under vacuum homogeneous, so
Heat preservation is stirred under 80 DEG C~85 DEG C of temperature environment afterwards, obtains reactant；
(5) by Ganodernaa lucidum extract, shrubby sophora extract, Salvia root P.E, glossy privet fruit extract, the bark of official magnolia bark extract, root of kirilow rhodiola
Extract, radix-polygoni multiflori extract, spikemoss extract, Fructus Gleditsiae Abnormalis extract and aloe vera extract, which are put into casserole, mixes 40-
It 45 minutes, is heated slowly with native furnace firewood mild fire；
(6) reactant that step (5) obtains is added in the reactant that step (4) obtains, is stirred under vacuum homogeneous, then exists
Heat preservation is stirred under 60-65 DEG C of temperature environment, obtains product.
7. the preparation method of the topical agent of acne-removing inflammation-diminishing according to claim 6, it is characterised in that: step (2) stirring
Soaking time is 20-25 minutes；It is 12-15 minutes that step (3), which stirs soaking time,；It is 20-22 that step (4), which stirs soaking time,
Minute；It is 10-12 minutes that step (6), which stirs soaking time,.
8. the preparation method of the topical agent of acne-removing inflammation-diminishing according to claim 6, it is characterised in that: taken out in step (4)
The angle of incidence is 7-8 minutes.
9. the preparation method of the topical agent of acne-removing inflammation-diminishing according to claim 6, it is characterised in that: true in step (4)
Sky stirring homogeneous 6-7 minutes.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112438915A (en) * | 2019-08-28 | 2021-03-05 | 广州市南方医康生物科技有限公司 | Skin care composition, cosmetic and preparation method thereof |
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| CN105012479A (en) * | 2015-07-22 | 2015-11-04 | 广州科玛生物科技有限公司 | Acne treatment composition and application thereof and acne treatment cream containing acne treatment composition |
| CN107753379A (en) * | 2017-12-05 | 2018-03-06 | 佛山微赢电子商务有限公司 | It is a kind of effectively anti-acne to desalinate Whelk-eliminating paste of pockmark and preparation method thereof simultaneously |
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2019
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105012479A (en) * | 2015-07-22 | 2015-11-04 | 广州科玛生物科技有限公司 | Acne treatment composition and application thereof and acne treatment cream containing acne treatment composition |
| CN107753379A (en) * | 2017-12-05 | 2018-03-06 | 佛山微赢电子商务有限公司 | It is a kind of effectively anti-acne to desalinate Whelk-eliminating paste of pockmark and preparation method thereof simultaneously |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112438915A (en) * | 2019-08-28 | 2021-03-05 | 广州市南方医康生物科技有限公司 | Skin care composition, cosmetic and preparation method thereof |
| CN112438915B (en) * | 2019-08-28 | 2023-05-05 | 广州市南方医康生物科技有限公司 | Skin care composition, cosmetic and method for producing same |
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Application publication date: 20190726 |