CN104721744A - Pharmaceutical composition with whitening function and preparation method thereof - Google Patents

Pharmaceutical composition with whitening function and preparation method thereof Download PDF

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Publication number
CN104721744A
CN104721744A CN201510128982.7A CN201510128982A CN104721744A CN 104721744 A CN104721744 A CN 104721744A CN 201510128982 A CN201510128982 A CN 201510128982A CN 104721744 A CN104721744 A CN 104721744A
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parts
extract
radix
pharmaceutical composition
talcum
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张辉勇
张恒
赵雅芳
谢红琴
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Chengdu Moral Education Shoes Industry Co Ltd
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Chengdu Moral Education Shoes Industry Co Ltd
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Abstract

The invention discloses a pharmaceutical composition with a whitening function and a preparation method thereof. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 6-100 parts of mulberry barks, 6-100 parts of dahurian angelica, 6-100 parts of talcum, 5-80 parts of curcuma, 5-80 parts of lemon peel, 5-80 parts of radix puerariae, 5-80 parts of aloes and 3-60 parts of glycyrrhiza uralensis. The invention also further discloses a specific preparation method of the pharmaceutical composition. The pharmaceutical composition has the effects of whitening and removing freckles and plays roles in preventing and treating chloasma, freckles, senile plaque and chromatosis. The pharmaceutical composition is simple in composition and novel in formula and has the advantages of low cost, remarkable treatment effect, no toxic or side effects and the like.

Description

A kind of pharmaceutical composition with whitening function and preparation method thereof
Technical field
The present invention relates to a kind of pharmaceutical composition with treatment or health-care effect, especially relate to a kind of pharmaceutical composition with whitening function and preparation method thereof.
Background technology
The skin of pale clean profit is the desired skin that people pursue, but excessive ultraviolet radiation can make the melanin in skin generate enzymes metabolism disorder, thus causes melanin pigmentation and then produce mottle, even produces skin carcinoma.Melanin generally can be divided into eumelanin and pheomelanin, now there are some researches show tryrosinase, dopachrome interconvertible enzyme is topmost enzyme in participation melanin forming process, wherein tryrosinase is the enzyme played a major role in melanin synthesis process, and between them, combined effect affects melanic generation.Melanin mainly contains two kinds of discharge regimes in vivo, one be melanin by melanocyte dendritic processes, to keratinocyte transfer, then go upward to horny layer with epidermis cell, come off with aging horn cell and excrete; Two is penetrate basement membrane after melanin is decomposed, dissolves and absorbs in skin, after the pheomelanin cytophagy of skin corium, takes lymph node to excrete from kidney through blood circulation by lymph fluid.Given this, skin whitening mainly by the activity of restraint of tyrosinase to reduce melanic generation or to promote that melanic Absorption And Metabolism impels melanin to discharge.
Traditional skin-whitening agents chemical substance often, as the hydroquinone of the mercury salt and effect of dispelling spots with whitening effect, though there is effect of quick whitening, to skin toxic side effect, life-time service can cause the untoward reaction such as contact dermatitis or permanent decolouring.Distillers yeast acid has cytotoxicity, and can increase the incidence rate of the gonad cell chromosome interchange and chromosomal aberration, but distillers yeast acid derivative whitening function is stronger, and toxic and side effects is less, and current skin-lightening cosmetic is many as effective ingredient; Though arbutin action temperature and, using dosage is excessive can produce the toxicity similar to distillers yeast acid.Modern study shows that numerous Chinese medicine all has the effect of restraint of tyrosinase activity.Chinese patent ZL201310340616.9 discloses a kind of crinkle-removing whitening frost, and this skin whitener is made up of Pseudobulbus Bletillae (Rhizoma Bletillae) 10-25 part, Radix Ampelopsis 10-20 part, Rhizoma Typhonii 10-35 part, Radix Trichosanthis 20-30 part, Rhizoma Ligustici 3-5 part, Rhizoma Chuanxiong 10-35 part, Rhizoma Pinelliae 3-10 part, Radix Angelicae Dahuricae 5-20 part, Radix Angelicae Sinensis 20-30 part, Exocarpium Citri Rubrum 20-35 part, Herba Leonuri 5-15 part and Semen Benincasae 10-15 part; Chinese patent ZL201410343874.7 discloses a kind of Chinese medicine for whitening, and this Chinese medicine is made up of Fructus Arctii 5-10 part, Radix Polygoni Multiflori 10-15 part, Cordyceps 3-5 part, Placenta Hominis 3-5 part, Ramulus et Folium Tupidanthi celyptrati 3-10 part, Radix Achyranthis Bidentatae 8-15 part, Radix Gentianae Macrophyllae 5-10 part, Herba speranskiae tuberculatae 9-15 part, Semen Coicis 5 parts, Radix Adenophorae (Radix Glehniae) 5 parts, 10 parts, Fructus Jujubae, 5 parts, Fructus Hordei Germinatus and Fructus Crataegi 10 parts.Although above-mentioned patent has the effect of whitening, its action direction is comparatively single, to xerosis cutis and pruritus all without therapeutical effect, all relatively weak to the therapeutical effect of pigmentation simultaneous phenomenon or secondary symptom.
Summary of the invention
One object of the present invention is to overcome the deficiencies in the prior art, provides a kind of composition simple, the pharmaceutical composition for restraint of tyrosinase activity of novel formula, this pharmaceutical composition has that cost is low, good effect, have no side effect, can life-time service.
The object of the invention is to be achieved through the following technical solutions:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following ratio of weight and number: Cortex Mori 6 ~ 100 parts, the Radix Angelicae Dahuricae 6 ~ 100 parts, 6 ~ 100 parts, Talcum, 5 ~ 80 parts, Rhizoma Curcumae Longae, Fericarpium Citri Limoniae 5 ~ 80 parts, Radix Puerariae 5 ~ 80 parts, Aloe 5 ~ 80 parts, 3 ~ 60 parts, Radix Glycyrrhizae.
Preferably, the ratio of weight and number of described each raw material is: Cortex Mori 10 ~ 80 parts, the Radix Angelicae Dahuricae 10 ~ 80 parts, 10 ~ 80 parts, Talcum, 8 ~ 70 parts, Rhizoma Curcumae Longae, Fericarpium Citri Limoniae 8 ~ 70 parts, Radix Puerariae 8 ~ 70 parts, Aloe 8 ~ 70 parts, 5 ~ 50 parts, Radix Glycyrrhizae.
Preferably, the ratio of weight and number of described each raw material is: Cortex Mori 15 ~ 60 parts, the Radix Angelicae Dahuricae 15 ~ 60 parts, 15 ~ 60 parts, Talcum, 12 ~ 50 parts, Rhizoma Curcumae Longae, Fericarpium Citri Limoniae 12 ~ 50 parts, Radix Puerariae 12 ~ 50 parts, Aloe 12 ~ 50 parts, 8 ~ 30 parts, Radix Glycyrrhizae.
Preferably, the ratio of weight and number of described each raw material is: Cortex Mori 20 ~ 50 parts, the Radix Angelicae Dahuricae 20 ~ 50 parts, 20 ~ 50 parts, Talcum, 15 ~ 40 parts, Rhizoma Curcumae Longae, Fericarpium Citri Limoniae 15 ~ 40 parts, Radix Puerariae 15 ~ 40 parts, Aloe 15 ~ 40 parts, 10 ~ 20 parts, Radix Glycyrrhizae.
Preferably, the ratio of weight and number of described each raw material is: Cortex Mori 20 parts, the Radix Angelicae Dahuricae 20 parts, 20 parts, Talcum, 15 parts, Rhizoma Curcumae Longae, Fericarpium Citri Limoniae 15 parts, Radix Puerariae 15 parts, Aloe 15 parts, 10 parts, Radix Glycyrrhizae.
Preferably, the ratio of weight and number of described each raw material is: Cortex Mori 8 parts, the Radix Angelicae Dahuricae 8 parts, 8 parts, Talcum, 6 parts, Rhizoma Curcumae Longae, Fericarpium Citri Limoniae 6 parts, Radix Puerariae 6 parts, Aloe 6 parts, 3 parts, Radix Glycyrrhizae.
A kind of pharmaceutical composition with whitening function, the ratio of weight and number of described each raw material is Cortex Mori extract 6 ~ 100 parts, Radix Angelicae Dahuricae extract 6 ~ 100 parts, Talcum extract 6 ~ 100 parts, Rhizoma Curcumae Longae extract 5 ~ 80 parts, lemon peel extract 5 ~ 80 parts, Radix Puerariae extract 5 ~ 80 parts, Aloe extract 5 ~ 80 parts, Radix Glycyrrhizae extract 3 ~ 60 parts.
Preferably, the ratio of weight and number of described each raw material is: Cortex Mori extract 8 parts, Radix Angelicae Dahuricae extract 8 parts, Talcum extract 8 parts, Rhizoma Curcumae Longae extract 6 parts, lemon peel extract 6 parts, Radix Puerariae extract 6 parts, Aloe extract 6 parts, Radix Glycyrrhizae extract 3 parts.
Prepare a method for above-mentioned arbitrary pharmaceutical composition, the method comprises the steps: S1: take Cortex Mori by weight, the Radix Angelicae Dahuricae, Talcum, Rhizoma Curcumae Longae, Fericarpium Citri Limoniae, Radix Puerariae, Aloe, Radix Glycyrrhizae; S2: conveniently preparation method is prepared into conventional formulation.
Foot bath preparation of the present invention is powder, granule, lotion, powder, decoction, unguentum.
Extract of the present invention can be water extract, alcohol extract, wherein alcohol extract preferred alcohol extract.
Cortex Mori of the present invention is the dry root bark of moraceae plants Mulberry, sweet, cold, returns lung meridian, has eliminating pathogen from the lung for relieving asthma, the effect of inducing diuresis to remove edema; The Radix Angelicae Dahuricae is the dry root of the umbellate form section plant Radix Angelicae Dahuricae or Radix angelicae dahuricae, pungent, warm, returns stomach, large intestine, lung meridian, has the dehumidifying of loose wind, understand things pain-stopping, the effect of detumescence and apocenosis; Talcum is silicates mineral talc race Talcum, main containing hydrous magnesium silicate, sweet, light, cold, returns bladder, lung, stomach warp, has inducing diuresis for treating stranguria syndrome, clearing away summer-heat, the effect of external damp eliminating sore; Rhizoma Curcumae Longae is the rhizome of zingiberaceous plant Rhizoma Curcumae Longae, and acrid, bitter, warm returns spleen, Liver Channel, has removing blood stasis circulation of qi promoting, the effect of inducing menstruation to relieve menalgia; The peel of Fericarpium Citri Limoniae Rutaceae both citrus Fructus Citri Limoniae, pungent, tepor, has the effect of promoting the circulation of QI to relieve pain; Radix Puerariae is the dry root of legume pueraria lobata, sweet, pungent, cool, returns spleen, stomach, lung meridian, has the effect of expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal, dredge the meridian passage; Aloe is the dry product of concentrated juice of liliaceous plant Aloe Barbadensis Miller, bitter, cold, and return liver, stomach, large intestine channel, have relieving constipation by purgation, purging liver-fire, parasite killing treats the effect of infantile malnutrition; Radix Glycyrrhizae is the dry root and rhizome of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L., and sweet, flat, GUIXIN, lung, spleen, stomach warp, have invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription.
For enabling above-mentioned dosage form realize, the acceptable adjuvant of pharmacy need be added when preparing these dosage forms, such as: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic etc., filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc., disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc., lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc., suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc., binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc., sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc., correctives comprises: sweeting agent and various essence, and antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, acetic acid chloroethene is fixed, Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods.
The invention has the beneficial effects as follows:
Pharmaceutical composition of the present invention can the activity of effective restraint of tyrosinase, has definite whitening and speckle dispelling curative effect.In addition, pharmaceutical composition of the present invention also have promote the production of body fluid moisturize, effect of killing parasites for relieving itching, effectively can prevent and treat xerosis cutis, desquamation and pruritus class symptom.The novel formula of pharmaceutical composition of the present invention, raw material is simple, and have feature with low cost, preparation method of the present invention is simple to operate, is applicable to suitability for industrialized production.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme of the present invention is described in further detail, but protection scope of the present invention is not limited to the following stated.
Embodiment 1:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 6g, Radix Angelicae Dahuricae 6g, Talcum 6g, Rhizoma Curcumae Longae 5g, Fericarpium Citri Limoniae 5g, Radix Puerariae 5g, Aloe 5g, Radix Glycyrrhizae 3g.
Embodiment 2:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 100g, Radix Angelicae Dahuricae 100g, Talcum 100g, Rhizoma Curcumae Longae 80g, Fericarpium Citri Limoniae 80g, Radix Puerariae 80g, Aloe 80g, Radix Glycyrrhizae 60g.
Embodiment 3:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 10g, Radix Angelicae Dahuricae 10g, Talcum 10g, Rhizoma Curcumae Longae 8g, Fericarpium Citri Limoniae 8g, Radix Puerariae 8g, Aloe 8g, Radix Glycyrrhizae 5g.
Embodiment 4:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 80g, Radix Angelicae Dahuricae 80g, Talcum 80g, Rhizoma Curcumae Longae 70g, Fericarpium Citri Limoniae 70g, Radix Puerariae 70g, Aloe 70g, Radix Glycyrrhizae 50g.
Embodiment 5:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 15g, Radix Angelicae Dahuricae 15g, Talcum 15g, Rhizoma Curcumae Longae 12g, Fericarpium Citri Limoniae 12g, Radix Puerariae 12g, Aloe 12g, Radix Glycyrrhizae 8g.
Embodiment 6:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 60g, Radix Angelicae Dahuricae 60g, Talcum 60g, Rhizoma Curcumae Longae 50g, Fericarpium Citri Limoniae 50g, Radix Puerariae 50g, Aloe 50g, Radix Glycyrrhizae 30g.
Embodiment 7:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 20g, Radix Angelicae Dahuricae 20g, Talcum 20g, Rhizoma Curcumae Longae 15g, Fericarpium Citri Limoniae 15g, Radix Puerariae 15g, Aloe 15g, Radix Glycyrrhizae 10g.
Embodiment 8:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 50g, Radix Angelicae Dahuricae 50g, Talcum 50g, Rhizoma Curcumae Longae 40g, Fericarpium Citri Limoniae 40g, Radix Puerariae 40g, Aloe 40g, Radix Glycyrrhizae 20g.
Embodiment 9:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 20g, Radix Angelicae Dahuricae 20g, Talcum 20g, Rhizoma Curcumae Longae 15g, Fericarpium Citri Limoniae 15g, Radix Puerariae 15g, Aloe 15g, Radix Glycyrrhizae 10g.
Embodiment 10:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 8g, Radix Angelicae Dahuricae 8g, Talcum 8g, Rhizoma Curcumae Longae 6g, Fericarpium Citri Limoniae 6g, Radix Puerariae 6g, Aloe 6g, Radix Glycyrrhizae 3g.
Embodiment 11:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 6g, Radix Angelicae Dahuricae 6g, Talcum 6g, Rhizoma Curcumae Longae 5g, Fericarpium Citri Limoniae 5g, Radix Puerariae 5g, Aloe 5g, Radix Glycyrrhizae 3g.
Embodiment 12:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 10g, Radix Angelicae Dahuricae 10g, Talcum 10g, Rhizoma Curcumae Longae 5g, Fericarpium Citri Limoniae 5g, Radix Puerariae 5g, Aloe 5g, Radix Glycyrrhizae 3g.
Embodiment 13:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori extract 6g, Radix Angelicae Dahuricae extract 6g, Talcum extract 6g, Rhizoma Curcumae Longae extract 5g, lemon peel extract 5g, Radix Puerariae extract 5g, Aloe extract 5g, Radix Glycyrrhizae extract 3g.
Embodiment 14:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori extract 100g, Radix Angelicae Dahuricae extract 100g, Talcum extract 100g, Rhizoma Curcumae Longae extract 80g, lemon peel extract 80g, Radix Puerariae extract 80g, Aloe extract 80g, Radix Glycyrrhizae extract 60g.
Embodiment 15:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori extract 8g, Radix Angelicae Dahuricae extract 8g, Talcum extract 8g, Rhizoma Curcumae Longae extract 6g, lemon peel extract 6g, Radix Puerariae extract 6g, Aloe extract 6g, Radix Glycyrrhizae extract 3g.
Embodiment 16:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori water extract 6g, Radix Angelicae Dahuricae water extract 6g, Talcum water extract 6g, Rhizoma Curcumae Longae water extract 5g, Fericarpium Citri Limoniae water extract 5g, Radix Puerariae water extract 5g, aloe water extract 5g, liquorice beverage extract 3g.
Embodiment 17:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori water extract 100g, Radix Angelicae Dahuricae water extract 100g, Talcum water extract 100g, Rhizoma Curcumae Longae water extract 80g, Fericarpium Citri Limoniae water extract 80g, Radix Puerariae water extract 80g, aloe water extract 80g, liquorice beverage extract 60g.
Embodiment 18:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori water extract 10g, Radix Angelicae Dahuricae water extract 10g, Talcum water extract 10g, Rhizoma Curcumae Longae water extract 8g, Fericarpium Citri Limoniae water extract 8g, Radix Puerariae water extract 8g, aloe water extract 8g, liquorice beverage extract 5g.
Embodiment 19:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori ethanol extraction 80g, Radix Angelicae Dahuricae ethanol extraction 80g, Talcum ethanol extraction 80g, Rhizoma Curcumae Longae ethanol extraction 70g, Fericarpium Citri Limoniae ethanol extraction 70g, Radix Puerariae ethanol extraction 70g, Aloe ethanol extraction 70g, Radix Glycyrrhizae ethanol extraction 50g.
Embodiment 20:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori ethanol extraction 15g, Radix Angelicae Dahuricae ethanol extraction 15g, Talcum ethanol extraction 15g, Rhizoma Curcumae Longae ethanol extraction 12g, Fericarpium Citri Limoniae ethanol extraction 12g, Radix Puerariae ethanol extraction 12g, Aloe ethanol extraction 12g, Radix Glycyrrhizae ethanol extraction 8g.
Embodiment 21:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori n-butanol extract 60g, Radix Angelicae Dahuricae n-butanol extract 60g, Talcum n-butanol extract 60g, Rhizoma Curcumae Longae n-butanol extract 50g, Fericarpium Citri Limoniae n-butanol extract 50g, Radix Puerariae n-butanol extract 50g, Aloe n-butanol extract 50g, Radix Glycyrrhizae n-butanol extract 30g.
Embodiment 22:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori n-butanol extract 20g, Radix Angelicae Dahuricae n-butanol extract 20g, Talcum n-butanol extract 20g, Rhizoma Curcumae Longae n-butanol extract 15g, Fericarpium Citri Limoniae n-butanol extract 15g, Radix Puerariae n-butanol extract 15g, Aloe n-butanol extract 15g, Radix Glycyrrhizae n-butanol extract 10g.
Embodiment 23:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori ethyl acetate extract 50g, Radix Angelicae Dahuricae ethyl acetate extract 50g, Talcum ethyl acetate extract 50g, Rhizoma Curcumae Longae ethyl acetate extract 40g, Fericarpium Citri Limoniae ethyl acetate extract 40g, Radix Puerariae ethyl acetate extract 40g, Aloe ethyl acetate extract 40g, Radix Glycyrrhizae ethyl acetate extract 20g.
Embodiment 24:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori ethyl acetate extract 20g, Radix Angelicae Dahuricae ethyl acetate extract 20g, Talcum ethyl acetate extract 20g, Rhizoma Curcumae Longae ethyl acetate extract 15g, Fericarpium Citri Limoniae ethyl acetate extract 15g, Radix Puerariae ethyl acetate extract 15g, Aloe ethyl acetate extract 15g, Radix Glycyrrhizae ethyl acetate extract 10g.
Embodiment 25:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori ligroin extraction 8g, Radix Angelicae Dahuricae ligroin extraction 8g, Talcum ligroin extraction 8g, Rhizoma Curcumae Longae ligroin extraction 6g, Fericarpium Citri Limoniae ligroin extraction 6g, Radix Puerariae ligroin extraction 6g, Aloe ligroin extraction 6g, Radix Glycyrrhizae ligroin extraction 3g.
Embodiment 26:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori ligroin extraction 6g, Radix Angelicae Dahuricae ligroin extraction 6g, Talcum ligroin extraction 6g, Rhizoma Curcumae Longae ligroin extraction 5g, Fericarpium Citri Limoniae ligroin extraction 5g, Radix Puerariae ligroin extraction 5g, Aloe ligroin extraction 5g, Radix Glycyrrhizae ligroin extraction 3g.
Embodiment 27:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori methanolic extract 100g, Radix Angelicae Dahuricae methanolic extract 100g, Talcum methanolic extract 100g, Rhizoma Curcumae Longae methanolic extract 80g, Fericarpium Citri Limoniae methanolic extract 80g, Radix Puerariae methanolic extract 80g, Aloe methanolic extract 80g, Radix Glycyrrhizae methanolic extract 60g.
Embodiment 28:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori methanolic extract 8g, Radix Angelicae Dahuricae methanolic extract 8g, Talcum methanolic extract 8g, Rhizoma Curcumae Longae methanolic extract 6g, Fericarpium Citri Limoniae methanolic extract 6g, Radix Puerariae methanolic extract 6g, Aloe methanolic extract 6g, Radix Glycyrrhizae methanolic extract 3g.
Embodiment 29:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 6g, Radix Angelicae Dahuricae 6g, Talcum 6g, Rhizoma Curcumae Longae 5g, Fericarpium Citri Limoniae 5g, Radix Puerariae 5g, Aloe 5g, and Radix Glycyrrhizae 3g, is conventionally prepared into powder.
Embodiment 30:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 100g, Radix Angelicae Dahuricae 100g, Talcum 100g, Rhizoma Curcumae Longae 80g, Fericarpium Citri Limoniae 80g, Radix Puerariae 80g, Aloe 80g, and Radix Glycyrrhizae 60g, is conventionally prepared into powder.
Embodiment 31:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 10g, Radix Angelicae Dahuricae 10g, Talcum 10g, Rhizoma Curcumae Longae 8g, Fericarpium Citri Limoniae 8g, Radix Puerariae 8g, Aloe 8g, and Radix Glycyrrhizae 5g, is conventionally prepared into powder.
Embodiment 32:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 80g, Radix Angelicae Dahuricae 80g, Talcum 80g, Rhizoma Curcumae Longae 70g, Fericarpium Citri Limoniae 70g, Radix Puerariae 70g, Aloe 70g, and Radix Glycyrrhizae 50g, is conventionally prepared into powder.
Embodiment 33:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 15g, Radix Angelicae Dahuricae 15g, Talcum 15g, Rhizoma Curcumae Longae 12g, Fericarpium Citri Limoniae 12g, Radix Puerariae 12g, Aloe 12g, and Radix Glycyrrhizae 8g, is conventionally prepared into powder.
Embodiment 34:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 60g, Radix Angelicae Dahuricae 60g, Talcum 60g, Rhizoma Curcumae Longae 50g, Fericarpium Citri Limoniae 50g, Radix Puerariae 50g, Aloe 50g, Radix Glycyrrhizae 30g., be conventionally prepared into powder.
Embodiment 35:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 20g, Radix Angelicae Dahuricae 20g, Talcum 20g, Rhizoma Curcumae Longae 15g, Fericarpium Citri Limoniae 15g, Radix Puerariae 15g, Aloe 15g, and Radix Glycyrrhizae 10g, is conventionally prepared into granule.
Embodiment 36:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 50g, Radix Angelicae Dahuricae 50g, Talcum 50g, Rhizoma Curcumae Longae 40g, Fericarpium Citri Limoniae 40g, Radix Puerariae 40g, Aloe 40g, Radix Glycyrrhizae 20g., be conventionally prepared into granule.
Embodiment 37:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 20g, Radix Angelicae Dahuricae 20g, Talcum 20g, Rhizoma Curcumae Longae 15g, Fericarpium Citri Limoniae 15g, Radix Puerariae 15g, Aloe 15g, and Radix Glycyrrhizae 10g, is conventionally prepared into unguentum.
Embodiment 38:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 8g, Radix Angelicae Dahuricae 8g, Talcum 8g, Rhizoma Curcumae Longae 6g, Fericarpium Citri Limoniae 6g, Radix Puerariae 6g, Aloe 6g, and Radix Glycyrrhizae 3g, is conventionally prepared into unguentum.
Embodiment 39:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 6g, Radix Angelicae Dahuricae 6g, Talcum 6g, Rhizoma Curcumae Longae 5g, Fericarpium Citri Limoniae 5g, Radix Puerariae 5g, Aloe 5g, and Radix Glycyrrhizae 3g, is conventionally prepared into effervescent.
Embodiment 40:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 10g, Radix Angelicae Dahuricae 10g, Talcum 10g, Rhizoma Curcumae Longae 5g, Fericarpium Citri Limoniae 5g, Radix Puerariae 5g, Aloe 5g, and Radix Glycyrrhizae 3g, is conventionally prepared into effervescent.
Embodiment 41:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori extract 6g, Radix Angelicae Dahuricae extract 6g, Talcum extract 6g, Rhizoma Curcumae Longae extract 5g, lemon peel extract 5g, Radix Puerariae extract 5g, Aloe extract 5g, Radix Glycyrrhizae extract 3g, is conventionally prepared into powder.
Embodiment 42:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori extract 100g, Radix Angelicae Dahuricae extract 100g, Talcum extract 100g, Rhizoma Curcumae Longae extract 80g, lemon peel extract 80g, Radix Puerariae extract 80g, Aloe extract 80g, Radix Glycyrrhizae extract 60g, is conventionally prepared into effervescent.
Embodiment 43:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori extract 8g, Radix Angelicae Dahuricae extract 8g, Talcum extract 8g, Rhizoma Curcumae Longae extract 6g, lemon peel extract 6g, Radix Puerariae extract 6g, Aloe extract 6g, Radix Glycyrrhizae extract 3g, is conventionally prepared into powder.
Embodiment 44:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori water extract 6g, Radix Angelicae Dahuricae water extract 6g, Talcum water extract 6g, Rhizoma Curcumae Longae water extract 5g, Fericarpium Citri Limoniae water extract 5g, Radix Puerariae water extract 5g, aloe water extract 5g, liquorice beverage extract 3g, is conventionally prepared into effervescent.
Embodiment 45:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori water extract 100g, Radix Angelicae Dahuricae water extract 100g, Talcum water extract 100g, Rhizoma Curcumae Longae water extract 80g, Fericarpium Citri Limoniae water extract 80g, Radix Puerariae water extract 80g, aloe water extract 80g, liquorice beverage extract 60g, is conventionally prepared into granule.
Embodiment 46:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori water extract 10g, Radix Angelicae Dahuricae water extract 10g, Talcum water extract 10g, Rhizoma Curcumae Longae water extract 8g, Fericarpium Citri Limoniae water extract 8g, Radix Puerariae water extract 8g, aloe water extract 8g, liquorice beverage extract 5g, is conventionally prepared into granule.
Embodiment 47:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori ethanol extraction 80g, Radix Angelicae Dahuricae ethanol extraction 80g, Talcum ethanol extraction 80g, Rhizoma Curcumae Longae ethanol extraction 70g, Fericarpium Citri Limoniae ethanol extraction 70g, Radix Puerariae ethanol extraction 70g, Aloe ethanol extraction 70g, Radix Glycyrrhizae ethanol extraction 50g, is conventionally prepared into tablet.
Embodiment 48:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori ethanol extraction 15g, Radix Angelicae Dahuricae ethanol extraction 15g, Talcum ethanol extraction 15g, Rhizoma Curcumae Longae ethanol extraction 12g, Fericarpium Citri Limoniae ethanol extraction 12g, Radix Puerariae ethanol extraction 12g, Aloe ethanol extraction 12g, Radix Glycyrrhizae ethanol extraction 8g, is conventionally prepared into tablet.
Embodiment 49:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori n-butanol extract 60g, Radix Angelicae Dahuricae n-butanol extract 60g, Talcum n-butanol extract 60g, Rhizoma Curcumae Longae n-butanol extract 50g, Fericarpium Citri Limoniae n-butanol extract 50g, Radix Puerariae n-butanol extract 50g, Aloe n-butanol extract 50g, Radix Glycyrrhizae n-butanol extract 30g, is conventionally prepared into capsule.
Embodiment 50:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori n-butanol extract 20g, Radix Angelicae Dahuricae n-butanol extract 20g, Talcum n-butanol extract 20g, Rhizoma Curcumae Longae n-butanol extract 15g, Fericarpium Citri Limoniae n-butanol extract 15g, Radix Puerariae n-butanol extract 15g, Aloe n-butanol extract 15g, Radix Glycyrrhizae n-butanol extract 10g, is conventionally prepared into capsule.
Embodiment 51:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 6g, Radix Angelicae Dahuricae 6g, Talcum 6g, Rhizoma Curcumae Longae 5g, Fericarpium Citri Limoniae 5g, Radix Puerariae 5g, Aloe 5g, Radix Glycyrrhizae 3g.Concrete using method is: S1: will add the water soaking 0.5 ~ 1 hour of medical material 6 ~ 8 times amount after the mixing of each raw material, decoct 15 ~ 20 minutes subsequently, filter and obtain decocting liquid, medicinal residues are for subsequent use; S2: the soak by water 20 ~ 30 minutes medicinal residues being added again 6 ~ 8 times of medical material amounts, filter and obtain decocting liquid, medicinal residues discard; S3: merge twice decocting liquid, pours into add water to after in basin and can be dipped into the foot back side, and water temperature is controlled to soak 20 ~ 30 minutes 35 ~ 40 DEG C time.
Embodiment 52:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 100g, Radix Angelicae Dahuricae 100g, Talcum 100g, Rhizoma Curcumae Longae 80g, Fericarpium Citri Limoniae 80g, Radix Puerariae 80g, Aloe 80g, Radix Glycyrrhizae 60g.Concrete using method is: S1: will add the water soaking 0.5 ~ 1 hour of medical material 6 ~ 8 times amount after the mixing of each raw material, decoct 15 ~ 20 minutes subsequently, filter and obtain decocting liquid, medicinal residues are for subsequent use; S2: the soak by water 20 ~ 30 minutes medicinal residues being added again 6 ~ 8 times of medical material amounts, filter and obtain decocting liquid, medicinal residues discard; S3: merge twice decocting liquid, pours into add water to after in basin and can be dipped into the foot back side, and water temperature is controlled to soak 20 ~ 30 minutes 35 ~ 40 DEG C time.
Embodiment 53:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 10g, Radix Angelicae Dahuricae 10g, Talcum 10g, Rhizoma Curcumae Longae 8g, Fericarpium Citri Limoniae 8g, Radix Puerariae 8g, Aloe 8g, Radix Glycyrrhizae 5g.Concrete using method is: S1: will add the water soaking 0.5 ~ 1 hour of medical material 6 ~ 8 times amount after the mixing of each raw material, decoct 15 ~ 20 minutes subsequently, filter and obtain decocting liquid, medicinal residues are for subsequent use; S2: the soak by water 20 ~ 30 minutes medicinal residues being added again 6 ~ 8 times of medical material amounts, filter and obtain decocting liquid, medicinal residues discard; S3: merge twice decocting liquid, pours into add water to after in basin and can be dipped into the foot back side, and water temperature is controlled to soak 20 ~ 30 minutes 35 ~ 40 DEG C time.
Embodiment 54:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 80g, Radix Angelicae Dahuricae 80g, Talcum 80g, Rhizoma Curcumae Longae 70g, Fericarpium Citri Limoniae 70g, Radix Puerariae 70g, Aloe 70g, Radix Glycyrrhizae 50g.Concrete using method is: S1: will add the water soaking 0.5 ~ 1 hour of medical material 6 ~ 8 times amount after the mixing of each raw material, decoct 15 ~ 20 minutes subsequently, filter and obtain decocting liquid, medicinal residues are for subsequent use; S2: the soak by water 20 ~ 30 minutes medicinal residues being added again 6 ~ 8 times of medical material amounts, filter and obtain decocting liquid, medicinal residues discard; S3: merge twice decocting liquid, pours into add water to after in basin and can be dipped into the foot back side, and water temperature is controlled to soak 20 ~ 30 minutes 35 ~ 40 DEG C time.
Embodiment 55:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 15g, Radix Angelicae Dahuricae 15g, Talcum 15g, Rhizoma Curcumae Longae 12g, Fericarpium Citri Limoniae 12g, Radix Puerariae 12g, Aloe 12g, Radix Glycyrrhizae 8g.Concrete using method is: S1: will add the water soaking 0.5 ~ 1 hour of medical material 6 ~ 8 times amount after the mixing of each raw material, decoct 15 ~ 20 minutes subsequently, filter and obtain decocting liquid, medicinal residues are for subsequent use; S2: the soak by water 20 ~ 30 minutes medicinal residues being added again 6 ~ 8 times of medical material amounts, filter and obtain decocting liquid, medicinal residues discard; S3: merge twice decocting liquid, pours into add water to after in basin and can be dipped into the foot back side, and water temperature is controlled to soak 20 ~ 30 minutes 35 ~ 40 DEG C time.
Embodiment 56:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 60g, Radix Angelicae Dahuricae 60g, Talcum 60g, Rhizoma Curcumae Longae 50g, Fericarpium Citri Limoniae 50g, Radix Puerariae 50g, Aloe 50g, Radix Glycyrrhizae 30g.Concrete using method is: S1: will add the water soaking 0.5 ~ 1 hour of medical material 6 ~ 8 times amount after the mixing of each raw material, decoct 15 ~ 20 minutes subsequently, filter and obtain decocting liquid, medicinal residues are for subsequent use; S2: the soak by water 20 ~ 30 minutes medicinal residues being added again 6 ~ 8 times of medical material amounts, filter and obtain decocting liquid, medicinal residues discard; S3: merge twice decocting liquid, pours into add water to after in basin and can be dipped into the foot back side, and water temperature is controlled to soak 20 ~ 30 minutes 35 ~ 40 DEG C time.
Embodiment 57:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 20g, Radix Angelicae Dahuricae 20g, Talcum 20g, Rhizoma Curcumae Longae 15g, Fericarpium Citri Limoniae 15g, Radix Puerariae 15g, Aloe 15g, Radix Glycyrrhizae 10g.Concrete using method is: S1: will add the water soaking 0.5 ~ 1 hour of medical material 6 ~ 8 times amount after the mixing of each raw material, decoct 15 ~ 20 minutes subsequently, filter and obtain decocting liquid, medicinal residues are for subsequent use; S2: the soak by water 20 ~ 30 minutes medicinal residues being added again 6 ~ 8 times of medical material amounts, filter and obtain decocting liquid, medicinal residues discard; S3: merge twice decocting liquid, pours into add water to after in basin and can be dipped into the foot back side, and water temperature is controlled to soak 20 ~ 30 minutes 35 ~ 40 DEG C time.
Embodiment 58:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 50g, Radix Angelicae Dahuricae 50g, Talcum 50g, Rhizoma Curcumae Longae 40g, Fericarpium Citri Limoniae 40g, Radix Puerariae 40g, Aloe 40g, Radix Glycyrrhizae 20g.Concrete using method is: S1: will add the water soaking 0.5 ~ 1 hour of medical material 6 ~ 8 times amount after the mixing of each raw material, decoct 15 ~ 20 minutes subsequently, filter and obtain decocting liquid, medicinal residues are for subsequent use; S2: the soak by water 20 ~ 30 minutes medicinal residues being added again 6 ~ 8 times of medical material amounts, filter and obtain decocting liquid, medicinal residues discard; S3: merge twice decocting liquid, pours into add water to after in basin and can be dipped into the foot back side, and water temperature is controlled to soak 20 ~ 30 minutes 35 ~ 40 DEG C time.
Embodiment 59:
Have a pharmaceutical composition for whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 20g, Radix Angelicae Dahuricae 20g, Talcum 20g, Rhizoma Curcumae Longae 15g, Fericarpium Citri Limoniae 15g, Radix Puerariae 15g, Aloe 15g, Radix Glycyrrhizae 10g.Concrete using method is: S1: will add the water soaking 0.5 ~ 1 hour of medical material 6 ~ 8 times amount after the mixing of each raw material, decoct 15 ~ 20 minutes subsequently, filter and obtain decocting liquid, medicinal residues are for subsequent use; S2: the soak by water 20 ~ 30 minutes medicinal residues being added again 6 ~ 8 times of medical material amounts, filter and obtain decocting liquid, medicinal residues discard; S3: merge twice decocting liquid, pours into add water to after in basin and can be dipped into the foot back side, and water temperature is controlled to soak 20 ~ 30 minutes 35 ~ 40 DEG C time.
Embodiment 60:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 8g, Radix Angelicae Dahuricae 8g, Talcum 8g, Rhizoma Curcumae Longae 6g, Fericarpium Citri Limoniae 6g, Radix Puerariae 6g, Aloe 6g, Radix Glycyrrhizae 3g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
Embodiment 61:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 6g, Radix Angelicae Dahuricae 6g, Talcum 6g, Rhizoma Curcumae Longae 5g, Fericarpium Citri Limoniae 5g, Radix Puerariae 5g, Aloe 5g, Radix Glycyrrhizae 3g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
Embodiment 62:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori 10g, Radix Angelicae Dahuricae 10g, Talcum 10g, Rhizoma Curcumae Longae 5g, Fericarpium Citri Limoniae 5g, Radix Puerariae 5g, Aloe 5g, Radix Glycyrrhizae 3g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
Embodiment 63:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori extract 6g, Radix Angelicae Dahuricae extract 6g, Talcum extract 6g, Rhizoma Curcumae Longae extract 5g, lemon peel extract 5g, Radix Puerariae extract 5g, Aloe extract 5g, Radix Glycyrrhizae extract 3g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
Embodiment 64:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori extract 100g, Radix Angelicae Dahuricae extract 100g, Talcum extract 100g, Rhizoma Curcumae Longae extract 80g, lemon peel extract 80g, Radix Puerariae extract 80g, Aloe extract 80g, Radix Glycyrrhizae extract 60g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
Embodiment 65:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori extract 8g, Radix Angelicae Dahuricae extract 8g, Talcum extract 8g, Rhizoma Curcumae Longae extract 6g, lemon peel extract 6g, Radix Puerariae extract 6g, Aloe extract 6g, Radix Glycyrrhizae extract 3g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
Embodiment 66:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori water extract 6g, Radix Angelicae Dahuricae water extract 6g, Talcum water extract 6g, Rhizoma Curcumae Longae water extract 5g, Fericarpium Citri Limoniae water extract 5g, Radix Puerariae water extract 5g, aloe water extract 5g, liquorice beverage extract 3g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
Embodiment 67:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori water extract 100g, Radix Angelicae Dahuricae water extract 100g, Talcum water extract 100g, Rhizoma Curcumae Longae water extract 80g, Fericarpium Citri Limoniae water extract 80g, Radix Puerariae water extract 80g, aloe water extract 80g, liquorice beverage extract 60g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
Embodiment 68:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori water extract 10g, Radix Angelicae Dahuricae water extract 10g, Talcum water extract 10g, Rhizoma Curcumae Longae water extract 8g, Fericarpium Citri Limoniae water extract 8g, Radix Puerariae water extract 8g, aloe water extract 8g, liquorice beverage extract 5g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
Embodiment 69:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori ethanol extraction 80g, Radix Angelicae Dahuricae ethanol extraction 80g, Talcum ethanol extraction 80g, Rhizoma Curcumae Longae ethanol extraction 70g, Fericarpium Citri Limoniae ethanol extraction 70g, Radix Puerariae ethanol extraction 70g, Aloe ethanol extraction 70g, Radix Glycyrrhizae ethanol extraction 50g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
Embodiment 70:
A kind of pharmaceutical composition with whitening function, it is made up of the raw material of following weight ratio: Cortex Mori ethanol extraction 15g, Radix Angelicae Dahuricae ethanol extraction 15g, Talcum ethanol extraction 15g, Rhizoma Curcumae Longae ethanol extraction 12g, Fericarpium Citri Limoniae ethanol extraction 12g, Radix Puerariae ethanol extraction 12g, Aloe ethanol extraction 12g, Radix Glycyrrhizae ethanol extraction 8g, said medicine is directly ground into powder, adds the water soaking of 90 ~ 100 DEG C, until foot bath is soaked 20 ~ 30 minutes when being cooled to 35 ~ 40 DEG C.
The medicine of above-mentioned any embodiment can adopt powder, powder, granule, effervescent, tablets and other formulations, carries out with bathing immersion way.Also said medicine can be prepared into facial film according to a conventional method simultaneously.
Beneficial effect of the present invention is verified below by concrete experimentation:
1. the experimentation of vitro Drug restraint of tyrosinase activity of the present invention
1.1 experiment material
Experimental drug: medicine of the present invention two skin whitening by name is fallen apart, thered is provided by pharmacology teaching and research room of Chengdu University of Traditional Chinese Medicine, specifically consist of Cortex Mori, the Radix Angelicae Dahuricae, Talcum, Rhizoma Curcumae Longae, Fericarpium Citri Limoniae, Radix Puerariae, Aloe and Radix Glycyrrhizae, concrete proportion compatibility is Cortex Mori 8 parts, the Radix Angelicae Dahuricae 8 parts, 8 parts, Talcum, 6 parts, Rhizoma Curcumae Longae, Fericarpium Citri Limoniae 6 parts, Radix Puerariae 6 parts, Aloe 6 parts, 3 parts, Radix Glycyrrhizae.To add the water soaking 0.5 ~ 1 hour of medical material 6 ~ 8 times amount after the mixing of each raw material, decoct 15 ~ 20 minutes subsequently, filter and obtain decocting liquid, medicinal residues are for subsequent use; Medicinal residues are added again the soak by water 20 ~ 30 minutes of 6 ~ 8 times of medical material amounts, filter and obtain decocting liquid, medicinal residues discard; Merge twice decocting liquid, decocting liquid is condensed into the medicinal liquid containing crude drug 1g/ml.Tryrosinase: purchased from American Worthington company, 2.5 ten thousand u/25mg, lot number: 20130601; Sodium hydrogen phosphate: purchased from Beijing Chemical Plant, 500g/ bottle, lot number: 20120607.
Experimental apparatus: calorstat: model: GZX-9146MBE, Medical Equipment Plant of Shanghai Boxun Industrial Co., Ltd.; Ultraviolet-visible spectrophotometer: model: Lambda25, U.S. Perkin Elmer Products.
1.2 experimental technique
Two skin whitenings of preparation variable concentrations are fallen apart medicinal liquid, 0.03% tyrosine 0.1mL is added respectively in every 1mL medicinal liquid, the calorstat of 37 DEG C hatches 10min, then tryrosinase (350u/mL) aqueous solution of 0.1mL is added, by solution mix homogeneously, after the calorstat being placed in 37 DEG C reacts 25min, measure absorbance (A) with spectrophotometer in 475mm; Blank group process replaces tyrosinase solution with isopyknic PBS, measures absorbance (B) with spectrophotometer in 475mm; Matched group replaces two skin whitening to fall apart medicinal liquid with isopyknic distilled water, measures absorbance (C) with spectrophotometer in 475mm; Blank group replaces two skin whitening to fall apart medicinal liquid with isopyknic distilled water, and replaces tyrosinase solution with isopyknic PBS, measures absorbance (D) with spectrophotometer in 75mm.Two skin whitening medicinal liquid that falls apart is divided into 25%, 50%, 60%, 70%, 80% and 90%6 concentration groups, and using arbutin (10mg/mL) as positive controls, the two skin whitening of each concentration medicinal liquid experiment of faling apart all repeats 3 times.
1.3 statistical procedures
Adopt the process of SPSS22.0 statistical software, continuous data adopts t inspection (to carry out t inspection to what meet normal distribution, the conversion of plan normal state is first carried out for the data not meeting normal distribution, carry out t inspection again, if meet normal distribution after still not meeting normal distribution or conversion after conversion, but do not meet the neat person of variance and carry out non parametric tests), enumeration data χ 2inspection, level data rank test.P value gets bilateral value, level of significance test α=0.05, and namely P < 0.05 represents statistics there were significant differences.
1.4 result
Two skin whitenings of variable concentrations medicinal liquid that falls apart is all inhibited to tyrosinase activity.In table 1.
Two skin whitenings of table 1 variable concentrations fall apart medicinal liquid to tyrosinase activity inhibitory action
Note: compare with matched group: ▲ P < 0.05, ▲ ▲ P < 0.01.
This research observes two skin whitening by experiment in vitro and to fall apart the inhibitory action of medicinal liquid to tyrosinase activity, and result shows that two skin whitenings of variable concentrations medicinal liquid that falls apart all has inhibitory action to tyrosinase activity, has definite whitening effect.
Show that pharmaceutical composition of the present invention can the activity of effective restraint of tyrosinase by experiment, there is definite whitening and speckle dispelling curative effect.In addition, pharmaceutical composition of the present invention also have promote the production of body fluid moisturize, effect of killing parasites for relieving itching, effectively can prevent and treat xerosis cutis and pruritus class symptom.In concrete clinical course, as xerodermatic treatment, Radix Ophiopogonis, Radix Rehmanniae can being added in order to increase clinical efficacy, as pruritis, Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae, Fructus Cnidii can be added in order to strengthen clinical efficacy.Show that pharmaceutical composition of the present invention has preventive and therapeutic action in various degree to chloasma, freckle, senile plaque and pigmentation by experiment.

Claims (10)

1. there is a pharmaceutical composition for whitening function, it is characterized in that: it is made up of the raw material of following ratio of weight and number: Cortex Mori 6 ~ 100 parts, the Radix Angelicae Dahuricae 6 ~ 100 parts, 6 ~ 100 parts, Talcum, 5 ~ 80 parts, Rhizoma Curcumae Longae, Fericarpium Citri Limoniae 5 ~ 80 parts, Radix Puerariae 5 ~ 80 parts, Aloe 5 ~ 80 parts, 3 ~ 60 parts, Radix Glycyrrhizae.
2. a kind of pharmaceutical composition with whitening function according to claim 1, it is characterized in that: the ratio of weight and number of described each raw material is: Cortex Mori 10 ~ 80 parts, the Radix Angelicae Dahuricae 10 ~ 80 parts, 10 ~ 80 parts, Talcum, 8 ~ 70 parts, Rhizoma Curcumae Longae, Fericarpium Citri Limoniae 8 ~ 70 parts, Radix Puerariae 8 ~ 70 parts, Aloe 8 ~ 70 parts, 5 ~ 50 parts, Radix Glycyrrhizae.
3. a kind of pharmaceutical composition with whitening function according to claim 1, it is characterized in that: the ratio of weight and number of described each raw material is: Cortex Mori 15 ~ 60 parts, the Radix Angelicae Dahuricae 15 ~ 60 parts, 15 ~ 60 parts, Talcum, 12 ~ 50 parts, Rhizoma Curcumae Longae, Fericarpium Citri Limoniae 12 ~ 50 parts, Radix Puerariae 12 ~ 50 parts, Aloe 12 ~ 50 parts, 8 ~ 30 parts, Radix Glycyrrhizae.
4. a kind of pharmaceutical composition with whitening function according to claim 1, it is characterized in that: the ratio of weight and number of described each raw material is: Cortex Mori 20 ~ 50 parts, the Radix Angelicae Dahuricae 20 ~ 50 parts, 20 ~ 50 parts, Talcum, 15 ~ 40 parts, Rhizoma Curcumae Longae, Fericarpium Citri Limoniae 15 ~ 40 parts, Radix Puerariae 15 ~ 40 parts, Aloe 15 ~ 40 parts, 10 ~ 20 parts, Radix Glycyrrhizae.
5. a kind of pharmaceutical composition with whitening function according to claim 1, is characterized in that: the ratio of weight and number of described each raw material is: Cortex Mori 20 parts, the Radix Angelicae Dahuricae 20 parts, 20 parts, Talcum, 15 parts, Rhizoma Curcumae Longae, Fericarpium Citri Limoniae 15 parts, Radix Puerariae 15 parts, Aloe 15 parts, 10 parts, Radix Glycyrrhizae.
6. a kind of pharmaceutical composition with whitening function according to claim 1, is characterized in that: the ratio of weight and number of described each raw material is: Cortex Mori 8 parts, the Radix Angelicae Dahuricae 8 parts, 8 parts, Talcum, 6 parts, Rhizoma Curcumae Longae, Fericarpium Citri Limoniae 6 parts, Radix Puerariae 6 parts, Aloe 6 parts, 3 parts, Radix Glycyrrhizae.
7. a kind of pharmaceutical composition with whitening function according to claim 1, it is characterized in that: the ratio of weight and number of described each raw material is: Cortex Mori extract 6 ~ 100 parts, Radix Angelicae Dahuricae extract 6 ~ 100 parts, Talcum extract 6 ~ 100 parts, Rhizoma Curcumae Longae extract 5 ~ 80 parts, lemon peel extract 5 ~ 80 parts, Radix Puerariae extract 5 ~ 80 parts, Aloe extract 5 ~ 80 parts, Radix Glycyrrhizae extract 3 ~ 60 parts.
8. a kind of pharmaceutical composition with whitening function according to claim 7, it is characterized in that: the ratio of weight and number of described each raw material is: Cortex Mori extract 8 parts, Radix Angelicae Dahuricae extract 8 parts, Talcum extract 8 parts, Rhizoma Curcumae Longae extract 6 parts, lemon peel extract 6 parts, Radix Puerariae extract 6 parts, Aloe extract 6 parts, Radix Glycyrrhizae extract 3 parts.
9. prepare a method for the pharmaceutical composition in claim 1 ~ 8 described in any one claim, it is characterized in that: the method comprises the steps:
S1: take Cortex Mori by weight, the Radix Angelicae Dahuricae, Talcum, Rhizoma Curcumae Longae, Fericarpium Citri Limoniae, Radix Puerariae, Aloe, Radix Glycyrrhizae;
S2: conveniently preparation method is prepared into conventional formulation.
10. a kind of method preparing Traditional Chinese medicine foot bath preparation according to claim 9, is characterized in that: described conventional formulation is powder, granule, lotion, powder, decoction, unguentum.
CN201510128982.7A 2015-03-23 2015-03-23 Pharmaceutical composition with whitening function and preparation method thereof Pending CN104721744A (en)

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Cited By (3)

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CN108498724A (en) * 2018-05-04 2018-09-07 四川生命源健康管理有限公司 The fair and tender spraying of vulva
CN115957158A (en) * 2021-10-11 2023-04-14 成都中医药大学附属医院 Composition for improving pigmentation, fading spots and whitening skin and preparation method and application thereof

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104940724A (en) * 2015-06-28 2015-09-30 梅顺 Cosmetic foot bath powder and method for producing the same
CN108498724A (en) * 2018-05-04 2018-09-07 四川生命源健康管理有限公司 The fair and tender spraying of vulva
CN115957158A (en) * 2021-10-11 2023-04-14 成都中医药大学附属医院 Composition for improving pigmentation, fading spots and whitening skin and preparation method and application thereof

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