CN100396302C

CN100396302C - Acne treating medicine

Info

Publication number: CN100396302C
Application number: CNB2004100839516A
Authority: CN
Inventors: 任成钧
Original assignee: Individual
Current assignee: Individual
Priority date: 2004-10-14
Filing date: 2004-10-14
Publication date: 2008-06-25
Anticipated expiration: 2024-10-14
Also published as: CN1634392A

Abstract

The present invention relates to an acne and comedo treating medicine which is prepared from phellodendron bark, scutellaria roots, rhubarb horsetails, eupatene, pearl powder, cottonrose hibiscus leaves, red precipitate, mercurous chloride, musk, borax and benne oil proportionally through pulverizing, mixing and grinding. The present invention belongs to a pure traditional Chinese medicine secret prescription, which adopts traditional Chinese medicinal plants as raw materials and is prepared by scientific proportioning. The present invention has the efficacy of freckle elimination, granulation promotion, degreasing, inflammation relief, blood circulation promotion, blood stasis elimination, heat dissipation, pathogenic fire purging, skin protection, beauty treatment, skin cell metabolism promotion, comedo inhibition, pore shrinkage and skin whitening and tapering. The present invention can be used for treating comedo, acne, foxiness, freckles, pigmentation, rosacea, bottle nose, red marks and black spots left by acne and various dermatitises. The present invention is pure natural and has the advantages of no side effect, no recurrence, simple prescription and low cost.

Description

A kind of medicine for the treatment of acne

Technical field

The present invention relates to a kind of medicine for the treatment of acne, relating to a kind of specifically is red, the black speck that can be used for treating that acne, acne, acne stay and the Pigmented beauty and skin care medicine of raw material with the Chinese crude drug.

Technical background

Acne is commonly called as acne, comedo, easily sends out in adolescence men and women's face and chest, and with seborrhea.Mainly comprise hoary hair's acne, blackhead, pimple, pustule and serious tuberosity cyst etc., usually be a place more a place send out again, in rapid succession.There is 80% adult once to suffer from acne according to statistics approximately in the blue and green period of development.Just state of an illness weight, time are different in size.Its age of onset generally mostly is 14-30 one full year of life, and youngster age of exquisite appearance just during this period of time, so regular meeting causes susceptible to lose temper due to restlessness, insomnia and dreamful sleep, and a series of uncomfortable diseases such as inappetence have finally influenced patient's appearance and health.Recent statistics finds, the teenager sickness rate in 11-25 year reaches more than 80%, and adolescence's sickness rate of 25-35 reaches more than 15%.Research thinks, the root and the deficiency of kidney yin of acne morbidity, and the negative and positive of kidney (endocrine) imbalance causes hyperactivity of the ministerial fire, or disharmony of Chong and Conception Channels, smoked women's head-ornaments on the lung stomach heat in blood stasis and causing.The research of modern medicine thinks that the generation of acne and dietary structure are unreasonable, psychentonia, and trace element deficiency, heredity etc. are all multifactor relevant.But principal element is an adolescence sexual development maturation, and the androgen level increases stimulates sebum secretion to increase, and is difficult to discharge and is gathered in the hair follicle, produces the pimple infringement.Sebaceous gland is drained and disturbance of blood circulation has created condition for again the infection breeding of antibacterial, and be inflamed around secondary hair follicle and the hair follicle abscess and tuberosity.At present, the medicine that can be used for the treatment of acne on the market is a lot, but often is not that to fall short of the reality be exactly that toxic and side effects is serious.For example popular acne medicine Accutane, it be nineteen eighty-two by the acne medicine that FDA Food and Drug Administration ratifies, also be the unique approved medicine that can effectively treat acne.Excite the people to be absorbed in the side effect of depressed state but but have, cause when serious committing suiside.According to the FDA report, since nineteen eighty-three, there have been 44 suicides relevant with the use of this medicine.Also have retinoic acid in addition, often claim tretinoin, retinoic acid.Skin heart is sharply expanded erythema occurred, the epidermal area plumpness has zest.Also unsuitable prolonged application, otherwise, acute inflammation may take place, cause ulcer.The external preparation for skin medicine is in the majority with hormone medicine at present, as: PIYANPING, fluocinonide or the like often can be covered inflammation, the illusion that causes acne to alleviate or fully recover.Hardly realize that hormone can stimulate sebaceous hyperplasia, make sebum secretion more vigorous, cover inflammation (being not real antiinflammatory) simultaneously and stimulate pigment cell's hypertrophy, thereby stay the pigmentation spots that is difficult to eliminate.Consequently: one brush hormone ointment just alleviates, and a drug withdrawal just recurrence increases the weight of, and forms and smears worse and worse, and bad more pernicious dependency circulation of smearing more finally causes the generation of corticosteroid dermatitis.

Summary of the invention

The object of the present invention is to provide a kind of Chinese medicine of selecting for use several kinds of Chinese medicinal materials to form through the science compatibility, blood circulation promoting and blood stasis dispelling, clearing away heat-fire, detoxicating, relieving inflammation, putrefaction-removing granulation-promoting, thereby reach acne treatment, the Cuo scar is calmed down and fully recover, tuberosity, trace are eliminated, the purpose of beauty and skin care, instant effect, a kind of medicine for the treatment of acne that has no side effect.

The object of the present invention is achieved like this: it is by Cortex Phellodendri 140-160 gram, Radix Scutellariae 140-160 gram, Radix Et Rhizoma Rhei 140-160 gram, herba lycopi 140-160 gram, Margarita 140-160 gram, Folium Hibisci Mutabilis 190-210 gram, Hydrargyri Oxydum Rubrum 15-25 gram, Calomelas 15-25 gram, Moschus 10-14 gram, Borax 40-60 gram and Oleum Sesami 140-160 gram proportioning, through a kind of medicine for the treatment of acne of pulverizing, mixed grinding forms.

Optimum ratio is: Cortex Phellodendri 150 grams, Radix Scutellariae 150 grams, Radix Et Rhizoma Rhei 150 grams, herba lycopi 150 grams, Margarita 150 grams, Folium Hibisci Mutabilis 200 grams, Hydrargyri Oxydum Rubrum 20 grams, Calomelas 20 grams, Moschus 12 grams, Borax 50 grams and Oleum Sesami 150 grams.

Wherein, Cortex Phellodendri, Cortex Phellodendri, (English) Amur Cork-treeBark, another name: Cortex Phellodendri, Cortex Phellodendri, Cortex Phellodendri, Cupressus funebris Endl..Bark for the yellow Pi Phellodendron of rutaceae amurense Rupr..Main contain little Pi's alkali, and contain palmatine (palmatine) jateorhizine (jatrorrhizine), phellodendrine (phellodendrine), Caulis menispermi and appoint alkali (menisperine), white bridge alkali (candicine), Cortex Phellodendri paulownia (obacunone) etc.Cold in nature, bitter in the mouth.Have heat clearing and damp drying, pathogenic fire purging removes steams, and the skin ulcer function is treated in detoxifcation.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin.Note: effect together for the bark of congener wampee P.chinense Schneid. (practise and claim " Cortex Phellodendri ").

Radix Scutellariae, Radix Scutellariae, (English) BaikalSkullcap Root, another name: Chimonanthus salicifolius S.Y.Hu., Radix Scutellariae, mashed heart grass.Root for labiate Radix Scutellariae Scutellariabaicalensis Georgi.Cold in nature, bitter in the mouth.Contain baicalin (baicalin), baicalin (baicalein), wogonoside (wogonoside), wogonin (wogonin), Radix Scutellariae ketone I, II (skullcapflavone I, II), oroxylin A (oroxy-linA) and campesterol.Has the hot dampness that disappears, eliminating fire and detoxication, hemostasis, antiabortive function.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Radix Et Rhizoma Rhei, Radix et Rhizoma Rhei, (English) Rhubarb, another name: certain herbaceous plants with big flowers leaf Radix Et Rhizoma Rhei, Beijing University's Huang, sky and water Radix Et Rhizoma Rhei.Be polygonum rheum palmatum Rheum palmatum L. rhizome and root.Cold in nature, bitter in the mouth.Contain anthraquinone glycoside and dissociated anthraquinone derivant, the latter comprises chrysophanic acid (rhein), emodin (emodin), chrysophanol (chrysophanol), aloe-emodin (aloe-emodin), physcione (physcion) etc.Has purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation function.Be used for excess-heat constipation, stagnant stomachache, not well, the jaundice due to damp-heat of dysentery.The root of congener Rheum tanguticum R.tanguticum Maxim.ex Balf., Rheum officinale R.officinale Baill. and rhizome are with being used as medicine as Radix Et Rhizoma Rhei.

The Herba Lycopi, Herba Lyeopi, (English) Shiny Bugleweed Herb, another name: herba lycopi, hair leaf Rhizoma Lycopi Lucidi, Rhizoma Lycopi Lucidi, manna seedling, lycopus lucidus, Phryganeajaponica Ml., Herba Lycopi.Dry aerial parts for labiate hair leaf lycopus lucidus Lycopus Iucidus Turcz.Var.hirtusRegel.Slightly warm in nature, bitter in the mouth, suffering.Contain volatile oil flavonoid glycoside, Saponin, phenols, saccharide and tannin.Has blood circulation promoting and blood stasis dispelling, the line water detumescence function.Be used for menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis stomachache, edema.

Margarita, Margarita, (English) Pearl, another name: pearl, natural pearls, Lian pearl.Margarita for Pteriidae animal Pteria martensii Dunker Pteria martensii (Dunker), Unionidae animal hydriopsis cumingii Hyriopsis cumingii (Lea) or the formation of cristaria plicata Cristariaplicata bivalve irriates such as (Leach).Sweet in the mouth, salty, cold in nature.GUIXIN, Liver Channel.Mainly contain calcium carbonate, contain aminoacid again.Aluminum, copper, ferrum, manganese are still arranged, elements such as sodium, zinc, silicon, peptide, strontium.Have tranquilizing mind, yin nourishing relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and expectorant is removed in heat clearing away, and removing nebula makes eye bright, the removing toxic substances and promoting granulation effect.Antiallergic, antihistaminic effect are arranged, to old nebula, thick nebula, mature cataract has regressive effect.Be used for palpitation with fear, the dysphoria with smothery sensation ， Hou Paralysis aphtha of quenching one's thirst, order is given birth to cataracta, and wound does not close up for a long time.

Folium Hibisci Mutabilis, Folium Hibisci Mutabilis, (English) CoffonroseHibiscus Leaf, another name: ground Hibisci Mutabilis, Hibisci Mutabilis, Cortex seu Flos Hibisci taiwanenss, Hu Lihua, three become flower, kapok.Leaf for Malvaceae plant Hibisci Mutabilis Hibiscus mutabilis L..Cool in nature, feeble QI, little suffering of distinguishing the flavor of.Contain flavonoid glycoside, phenols, aminoacid, reducing sugar, phlegmatic temperament.Has the lung heat clearing removing heat from blood, the detumescence and apocenosis function.Be used for cough due to lung-heat, hypertrophic rhinitis, lymphadenitis, appendicitis, carbuncle furuncle abscess, acute otitis media, burn, scald.

Hydrargyri Oxydum Rubrum, (English) hydrargyri oxydum rubrum, another name: hydrargyrum oxydatum crudum, Hydrargyri Oxydum Rubrum, hydrargrum oxydatum crudum, XIAOJIN DAN, Huang Sheng etc.Contain mercury oxide (HgO) and must not be less than 99.0%.Acrid in the mouth, hot in nature; Very toxic.Have the poison of dialling, remove pus, removing the necrotic tissue, granulation promoting function.Be used for the carbuncle furuncle, syphilitic chancre, all malignant boil, meat is dark violet black, and slough does not go, sinus tract flaccidity pipe, pus is dripping, does not close up for a long time.

Calomelas, Calomelas, (English) Calomel, another name: hydrargyrum powder, high and steep powder, CALOMELAS, greasy powder, argentum powder, sweep basin.Mainly contain chlorination mercurous (Mercurous chloride, Hg2Cl2 or HgCl).Natural product person, name hornquicksilver (Horn-quicksilver), but usually all use artificial preparation, be tasteless colourless (being with faint yellow usually) flake-like crystal.Chemically have another name called calomel (Calomel), its dry product contains HgCl must not be less than 99.6%.Acrid in the mouth, cold in nature; Poisonous.Return large intestine, small intestine meridian.The external parasite killing, counteracting toxic substances is held back skin ulcer; The removing food stagnancy that eliminates the phlegm for oral administration, the relieving constipation of relieving oedema or abdominal distension through diuresis or purgation.External treatment is used for scabies, stubborn dermatitis, ecthyma, syphilis, skin infection, eczema; The sputum that is used for for oral administration stagnates, and edema expands, difficulty in urination and defecation.

Moschus, Moschus, (English) Borax, another name: Moschus, Moschus, Moschus etc.Be the dry secretions in animal in deer family woods Moschus moschiferous Moschus berezovskii Flerov, horse Moschus moschiferous M.sifanicus Przewalski or the ripe male body note capsule of former Moschus moschiferous M.moschiferus Linnaeus.Contain the about 0.9-3% of muscone (muscone), and contain muscopyridine, 11 kinds of androstanes (androstane) derivant, still contain cholesterol class, fat, protein, wax and inorganic salt.Acrid in the mouth, warm in nature, GUIXIN, spleen channel.Has the refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, pain relieving, the effect of hastening parturition.Be used for excess syndrome of stroke coma, epidemic febrile disease heat and fall into the cards such as paralysis that pericardium, expectorant heat are hoodwinked thinking, infantile convulsion, apoplexy syncope due to accumulation of phlegm, sore swollen toxin, laryngopharynx swelling and pain, blood stasis amenorrhea, note of the ancient Chinese abdominal mass, trusted subordinate's sudden pain, traumatic injury, anemofrigid-damp arthralgia, difficult labour, stillborn fetus, retention of placenta, angina pectoris, coronary heart disease, vitiligo, digestive tract tumor, poliomyelitis.

Borax, Borax, (English) Borax, another name: big friend's sand, Borax, roc sand, Borax, yellow Borax, white Borax, Borax bob, month stone, basin sand, Borax Borax, borax, Borax(calcined) etc.Be the refining crystallization that forms of mineral Borax warp.Chemical constituent be sodium tetraborate (Na2B4O7,10H2O).Mostly be fabricated product, main borax Na2[B4O5 (OH) 4] .8H2O.Sweet-salty, cool in nature, nontoxic, go into lung, stomach warp.Has the heat clearing away expectorant, the detoxifcation preservative efficacy.Control laryngopharynx swelling and pain, aphtha of the mouth and tongue, conjunctival congestion cataracta; Bone is choked, and is dysphagic, and cough expectorant is thick.

Oleum Sesami, another name: siritch, Oleum sesami, sesame oil, Wang's oil, Oleum sesami, the Lushui River oil.It is the fatty oil that squeezes from Hu section plant sesame seed.Main component is a unsaturated fatty acid in the Oleum Sesami, accounts for 85%～90%, and oleic acid and linoleic acid respectively account for 50% basically, also contains mineral such as protein, sesamin, vitamin E, lecithin, sucrose, calcium, phosphorus, ferrum.Sweet in the mouth is cool in nature, has the effect of loosening bowel to relieve constipation, removing toxic substances and promoting granulation.According to putting down in writing on the Compendium of Material Medica: " have moisturize, the merit of detoxifcation, pain relieving, detumescence." " not Lu " say: " sharp large intestine, afterbirth does not fall.Survivor's lump of rubbing is swollen, gives birth to alopecia." granulation promoting meat is arranged, the effect of the pain that relieves the pain, subduing inflammation, benefit rhagades of the skin.

The present invention compared with prior art, it belongs to pure traditional Chinese medicine secret recipe, with the Chinese medicine material is raw material, the employing scientific matching is prepared from, effect with speckle dispelling granulation promoting, defat antiinflammatory, blood circulation promoting and blood stasis dispelling, disappear diarrhea of heat type fire, cosmetology, can impel skin cell metabolism, suppress acne, pore refining, brighten the skin that attenuates, can be used for treating red seal, black speck and various dermatitis that acne, acne, brown patch, freckle, pigmentation, rosacea, acne rosacea, acne stay.Its pure natural has no side effect, do not have repeatedly and also prescription simple, with low cost.

The specific embodiment

Further specify the present invention below in conjunction with embodiment

Embodiment 1

Choosing the Cortex Phellodendri, Radix Scutellariae, Radix Et Rhizoma Rhei, herba lycopi, Margarita, Folium Hibisci Mutabilis, Hydrargyri Oxydum Rubrum, Calomelas, Moschus, Borax and the Oleum Sesami that meet Pharmacopoeia of the People's Republic of China regulation respectively is raw material, the roguing dedusting.Weigh Cortex Phellodendri 150 grams, Radix Scutellariae 150 grams, Radix Et Rhizoma Rhei 150 grams, herba lycopi 150 grams, Margarita 150 grams, Folium Hibisci Mutabilis 200 grams, Hydrargyri Oxydum Rubrum 20 grams, Calomelas 20 grams, Moschus 12 grams, Borax 50 grams and Oleum Sesami 150 grams after the cleaning, pulverize, grind with colloid mill, make the packing of 200-300 order emulsifiable paste, promptly get a kind of medicine for the treatment of acne.Medication is once wiped in the affected part every night, keeps 10 hours.

Embodiment 2

Choosing the Cortex Phellodendri, Radix Scutellariae, Radix Et Rhizoma Rhei, herba lycopi, Margarita, Folium Hibisci Mutabilis, Hydrargyri Oxydum Rubrum, Calomelas, Moschus, Borax and the Oleum Sesami that meet Pharmacopoeia of the People's Republic of China regulation respectively is raw material, the roguing dedusting.Weigh Cortex Phellodendri 140 grams, Radix Scutellariae 160 grams, Radix Et Rhizoma Rhei 140 grams, herba lycopi 160 grams, Margarita 140 grams, Folium Hibisci Mutabilis 210 grams, Hydrargyri Oxydum Rubrum 15 grams, Calomelas 25 grams, Moschus 10 grams, Borax 60 grams and Oleum Sesami 140 grams after the cleaning, pulverize, grind with colloid mill, make 200 order emulsifiable paste packing, promptly get a kind of medicine for the treatment of acne.Medication is once wiped in the affected part every night, keeps 10 hours.

Embodiment 3

Choosing the Cortex Phellodendri, Radix Scutellariae, Radix Et Rhizoma Rhei, herba lycopi, Margarita, Folium Hibisci Mutabilis, Hydrargyri Oxydum Rubrum, Calomelas, Moschus, Borax and the Oleum Sesami that meet Pharmacopoeia of the People's Republic of China regulation respectively is raw material, the roguing dedusting.Weigh Cortex Phellodendri 160 grams, Radix Scutellariae 140 grams, Radix Et Rhizoma Rhei 160 grams, herba lycopi 140 grams, Margarita 160 grams, Folium Hibisci Mutabilis 190 grams, Hydrargyri Oxydum Rubrum 25 grams, Calomelas 15 grams, Moschus 14 grams, Borax 40 grams and Oleum Sesami 160 grams after the cleaning, pulverize, grind with colloid mill, make 300 order emulsifiable paste packing, promptly get a kind of medicine for the treatment of acne.Medication is once wiped in the affected part every night, keeps 10 hours.

Embodiment 4

King XX, woman, 24 years old, the Fengnan District people of Tangshan City.Diagnosis: closed comedones.Treatment: medication was almost recovered after 2 months.

Embodiment 5

Zheng XX, man, 24 years old, the Kaiping District people of Tangshan City.Diagnosis: acne cystica.Treatment: 1 month acne cystica symptom of medication is obviously improved, and medication was fully recovered after 3 months.

Embodiment 6

Zheng XX, woman, 28 years old, happiness people from garden of Tangshan City.Diagnosis: acne.Treatment: 10 days rear faces of medication occur red, swell, itch, the pain symptom, it is more that pimple goes out, and continues the medication symptom and alleviate gradually, medication is after 2 months, recovery from illness.

Embodiment 7

Peace X, man, 24 years old, the Guye District people of Tangshan City.Diagnosis: acne nodosum.Treatment: medication was almost recovered after 2 months.

Embodiment 8

Pay XX, woman, 47 years old, the Guye District people of Tangshan City.Diagnosis: Flos Rosae Rugosae property acne (acne rosacea), corticosteroid dermatitis.Treatment: medication took a turn for the better after 2 months.

Embodiment 9

King XX, woman, 51 years old, the Guye District people of Tangshan City.Diagnosis: Flos Rosae Rugosae property acne (acne rosacea), corticosteroid dermatitis.Treatment: medication after 2 months skin lesion alleviate, redness shoals, medication is after 3 months, recovery from illness, it is normal that skin recovers.

Embodiment 10

Zhao XX, woman, 30 years old, the Guye District people of Tangshan City.Diagnosis: chloasma.The treatment: medication after 1 month black speck become ill-defined fragmentary several piece, color shoals, medication is after 3 months, it is normal that skin recovers substantially.

Embodiment 11

Poplar XX, man, 45 years old, the Tang Tao people of Tangshan City.Diagnosis: acne rosacea.The treatment: medication after 2 months the patient recover normal.

Embodiment 12

Peace XX, the woman, 24 years old, Liu of Tangshan City collectd the people.Diagnosis: freckle.Treatment: medication is after 3 months, and speckle is desalinated.

Embodiment 13

Still XX, woman, 26 years old, people from Ji County, Tangshan City.Diagnosis: verruca plana.Treatment: medication was almost recovered in 2 months.

Embodiment 14

The acute dermal toxicity test:

The preparation of animal: select each 20 of two kinds of sex adult rats for use.Weight range is 200-300g.

Dosage and grouping: the experimental rat of two kinds of sexes is divided into 4 groups respectively at random, every group of 10 rats.Each dosage group is respectively 600mg/kg, 900mg/kg, 1200mg/kg, 1500mg/kg.

Test method: the present invention is coated on rat back equably, and covers with oilpaper and two-layer gauze, reuse nonirritant adhesive plaster or binder are fixed, and lick with slip-off preventing and rat and are tried thing, altogether drug of topical application 24h.After the off-test, available warm water or appropriate solvent are removed residual the present invention.Observe a week.

Result of the test: administration had found afterwards that rat produced side reaction or whole body poisoning manifestations.

Discuss: can determine that transdermal flux effect of the present invention does not produce toxicity.

Claims

1. medicine for the treatment of acne, it is by Cortex Phellodendri 140-160 gram, Radix Scutellariae 140--160 gram, Radix Et Rhizoma Rhei 140-160 gram, herba lycopi 140-160 gram, Margarita 140-160 gram, Folium Hibisci Mutabilis 190-210 gram, Hydrargyri Oxydum Rubrum 15-25 gram, Calomelas 15-25 gram, Moschus 10-14 gram, Borax 40-60 gram and Oleum Sesami 140-160 gram proportioning, through pulverizing, mixed grinding forms.

2. a kind of medicine for the treatment of acne according to claim 1, wherein Cortex Phellodendri 150 grams, Radix Scutellariae 150 grams, Radix Et Rhizoma Rhei 150 grams, herba lycopi 150 grams, Margarita 150 grams, Folium Hibisci Mutabilis 200 grams, Hydrargyri Oxydum Rubrum 20 grams, Calomelas 20 grams, Moschus 12 grams, Borax 50 grams and Oleum Sesami 150 grams.