CN102293931B - Traditional Chinese medicinal composition, clinical preparation and preparation methods thereof - Google Patents

Abstract

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicinal composition, a clinical preparation and preparation methods thereof. The traditional Chinese medicinal composition comprises the following components in parts by weight: 5-10 parts of manchurian wildginger, 5-10 parts of rhizoma bletillae, 5-10 parts of pericarpium zanthoxyli, 5-10 parts of cassia twig, 5-10 parts of angelica dahurica, 5-10 parts of gynura root, 5-10 parts of raw rhubarb, 5-10 parts of salvia miltiorrhiza, 5-10 parts of raw aconite root, 5-10 parts of raw radix aconiti agrestis, 10-20 parts of raw liquorice root, 15-30 parts of camphor, 10-20 parts of lilac daphne flower and 8-10 parts of calcined plaster. The test of medicament effectiveness shows that the traditional Chinese medicinal composition provided by the invention and preparations of chilblain tincture and chilblain cream can be effectively used for curing chilblain.

Description

A kind of traditional Chinese medicine composition, clinical preparation and preparation method

technical field

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition, a clinical preparation and a preparation method.

Background technique

Frostbite is a localized inflammatory damage caused by cold. The patient's back of the hands, feet, auricles, cheeks and other parts are often attacked by cold evil for a long time, resulting in redness, swelling, coldness, itching and pain, and even dark purple skin and ulceration. About 200 million people in my country suffer from frostbite every year, mainly children, women and the elderly. Once chilblain occurs, it is often difficult to heal quickly in the cold season, and patients suffer from it.

At present, there are multiple medicines for treating frostbite, all of which cannot eliminate symptoms such as redness, swelling, and itching in a short period of time after use, and cannot completely cure erosion and intractable frostbite, and the cure rate is low.

Contents of the invention

In view of this, the present invention provides a traditional Chinese medicine composition, clinical preparation and preparation method for treating frostbite. The traditional Chinese medicine composition and preparation have good therapeutic effects on frostbite.

In order to achieve the above-mentioned purpose of the invention, the present invention provides the following technical solutions:

A traditional Chinese medicine composition for treating frostbite, characterized in that it is made of the following raw materials in parts by weight:

Among them, Asarum, also known as fine ginseng and cigarette pot flower, belongs to the Aristolochiaceae, Asarum genus, and the whole plant is used as medicine (because of the high content of aristolochic acid in the aerial parts, and aristolochic acid has nephrotoxicity, Therefore, the 2005 edition of "Chinese Pharmacopoeia" has been changed to roots and rhizomes as medicine), warm in nature, pungent in taste, and warm in nature, dispelling cold through the meridian, transforming drink, dispelling wind and relieving pain, and mainly treating wind-cold headache, phlegm retention, cough and asthma, rheumatic arthralgia, toothache, Syndrome etc.

Bletilla striata is the dry tuber of orchid plant white and Bletilla striata (Thunb.) Reichb.f., has the effects of astringent and hemostasis, detumescence and granulation promoting, etc., and external application is used to treat wound bleeding, carbuncle, scald, furuncle and the like.

Chuanjiao is the dried and mature peel (Zanthoxylum schinifolium Sieb. et Zucc.) of Rutaceae green peppers (pepper, green pepper, sansho, dog pepper) Zanthoxylumschinifolium Sieb. et Zucc. or Zanthoxylumbungeanum Maxim. And the seeds (pepper order) are used as medicine, which has the functions of invigorating the stomach, warming the middle and dispelling cold, dehumidifying and relieving pain, killing insects and detoxifying, relieving itching and relieving fishy smell, and mainly treating vomiting, wind-cold-damp arthralgia, toothache and other diseases.

Guizhi is the dry twig of Cinnamomum cassia Presl, a plant of Lauraceae, mainly produced in Guangxi, Guangdong and Yunnan. Cut off the shoots in spring and summer, dry in the sun or in the shade, and cut into thin slices or small pieces for use. Enneng can produce sweat and relieve muscles, warm meridians, help yang transform qi, calm and lower qi, and is used for wind-cold cold, cold pain in the abdomen, amenorrhea due to blood cold, joint pain, phlegm retention, edema, palpitation, and rushing to the dolphin.

Baizhi, the scientific name is A.dahurica (Fisch.) Benth.et Hook, also known as Xiangbaizhi (Fujian, Taiwan, Zhejiang and other provinces), Sakhalin Baizhi (Sichuan), and Qi Baizhi (Henan, Hebei), which are Umbelliferae plants Xing'an Baizhi (Qing Baizhi) (Angelica dahurica Benth.et Hook.), Kuer Baizhi (Chuan Baizhi) (A.anomala Lall.) and Hang Baizhi (Scent Baizhi) (A.taiwaniana Boiss.,epith.mut.) The root is used as medicine, containing isoimperatorin, imperatorin, bergapten, phellopterin, oxypeucedanin, etc. , dispelling cold and relieving pain, dehumidifying and resuscitating, the effect of reducing swelling and discharging pus, mainly treating wind-cold cold, headache, rhinitis, toothache. Red and white leucorrhea, pain, furuncle, swollen toxin and other diseases.

Panax notoginseng is the dried root of Panax notoginseng (Burk.) F.H.Chen, a plant of Araliaceae, containing saponins, mainly ginsenosides Rb1, Rg1, Rg2 and a small amount of ginsenosides Ra, Rb2, Rb and Re. In addition, it still contains flavonoid glycosides, starch, protein, oil, etc., which can dissipate blood stasis and stop bleeding, reduce swelling and relieve pain. Tumbling and swelling.

Raw rhubarb is a decoction piece of raw medicinal materials. Its main functions are to attack stagnation, remove blood stasis and stop bleeding, and relieve constipation. It is used for gastrointestinal excess heat stagnation and constipation.

Salvia miltiorrhiza, also known as red ginseng, purple miltiorrhiza, red root, etc., is the dry root and rhizome of Salvia miltiorrhiza Bge., a dicotyledonous plant Labiatae Salvia genus. It is mainly produced in Anhui, Henan, Shaanxi and other places. Its efficacy is Promoting blood circulation and regulating menstruation, dispelling blood stasis and relieving pain, cooling blood and eliminating carbuncle, clearing away heart-fire and restlessness, nourishing blood and calming the nerves.

Shengchuan Aconitum is the mother root of Aconitum carmichaeli Debx., a plant of Ranunculaceae, with a total alkaloid content of 2.3%, esters of 1.0%, and aconitine of 0.3%. Mainly contain aconitine, mesaconitine, talatisamine, jasaconitine, benzoylaconine, benzoyl aconitine Head amine (benzoylmesaconine) and benzoyl aconine (benzoylhypaconine) and so on. Enneng can dispel wind and dampness, warm meridians and relieve pain, and is used for wind-cold-damp arthralgia, joint pain, cold pain in trusted subordinates, and pain caused by cold colic.

Aconitum aconitum is the root tuber of the perennial herb Aconitum (wild species) or Aconitum aconitum in the family Ranunculaceae. Expelling wind and dampness is arranged, the effect of warming meridians to relieve pain is used for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold pain, colic caused by cold, anesthesia and pain relief.

Raw licorice is the dry root and rhizome of Glycyrrhiza uralensis Fisch., Glycyrrhiza Inflata Bat. or Glycyrrhiza Glabra L., a leguminous plant of Glycyrrhiza uralensis Fisch. Reconciling the effects of various medicines, it is used for weakness of the spleen and stomach, lassitude, palpitation, shortness of breath, cough with profuse phlegm, abdominal distension, acute pain of extremities, carbuncle and sore, and relieves drug toxicity and potency.

Camphor, scientific name: 1,7,7-trimethylbicyclo[2,2,1]heptane-2-one. A cyclohexane monoterpene derivative. Distilled from the bark and wood of the camphor tree, the ketones have the functions of dehumidification and killing insects, warming and relieving pain, resuscitating and repelling foulness, and mainly treating scabies, itching, bruises, and toothache.

Daphne genkwa, Daphne genkwa Sieb is the dry flower bud of Daphne genkwa Sieb, a plant of Daphneaceae. It has the effect of purging water and drinking, detoxifying and killing insects. , two adverse bowel movements; external treatment of scabies bald sores, frostbite.

Calcined gypsum is a processed product of gypsum, which can absorb dampness, promote muscle growth, suppress sores, and stop bleeding; externally treat ulcers, eczema itching, water and fire burns, traumatic bleeding and other diseases.

Based on this, the traditional Chinese medicine composition provided by the invention is made from the above-mentioned raw materials.

The present invention also provides a clinical preparation comprising the above-mentioned traditional Chinese medicine composition.

In some embodiments of the present invention, the clinical preparation containing the above-mentioned traditional Chinese medicine composition is a tincture, and in other embodiments provided by the present invention, the clinical preparation containing the above-mentioned traditional Chinese medicine composition is a cream.

The present invention also provides a preparation method of a traditional Chinese medicine composition for treating frostbite, which comprises taking 5-10 parts by weight of Herba Asarum, 5-10 parts by weight of Bletilla striata, 5-10 parts by weight of Chuanjiao, 5-10 parts by weight of Guizhi, 5-10 parts by weight of Angelica dahurica, 5-10 parts by weight of Panax notoginseng, 5-10 parts by weight of raw rhubarb, 5-10 parts by weight of salvia miltiorrhiza, 5-10 parts by weight of Shengchuanwu, 5-10 parts by weight Add 600-1000 mL of water, stir for 30-60 minutes, cool to 40 ~60°C, add 15-30 parts by weight of camphor, stir and cool to 20-30°C to obtain.

The present invention also provides the traditional Chinese medicine composition prepared by the above preparation method.

The present invention also provides a kind of tincture for treating frostbite. The preparation method is as follows: 5-10 parts by weight of Asarum, 5-10 parts by weight of Bletilla striata, 5-10 parts by weight of Chuanjiao, 5-10 parts by weight of Guizhi, 5-10 parts by weight of Angelica dahurica, 5-10 parts by weight of Panax notoginseng, 5-10 parts by weight of raw rhubarb, 5-10 parts by weight of salvia miltiorrhiza, 5-10 parts by weight of Shengchuanwu, 5-10 parts by weight Aconitum aconiti in parts by weight, 10-20 parts by weight of raw licorice, 10-20 parts by weight of Daphne genkwa, and calcined gypsum of 8-10 parts by weight are pulverized, and then 200-250 mL of concentration is 75% and 60% ethanol Leaching, adding 15 to 30 parts by weight of camphor and mixing to obtain.

Preferably, in the preparation method of the tincture, the leaching is soaking at 15-40° C. for 7-15 days or soaking at 50° C. in a water bath for 48-72 hours.

In some embodiments provided by the present invention, the preparation method of the tincture is specifically made from the following raw materials in parts by weight:

After taking the rest of the raw materials except camphor and pulverizing them, soak them in 200-250mL of 75% ethanol at 15-40°C for 7-15d or in a water bath at 50°C for 48-72h, and collect the first extract by filtration After the filtrate; collect the filter residue, soak in 200-250mL of ethanol with a concentration of 60% at 15-40°C for 7-15d or soak in a water bath at 50°C for 48-72h, collect the filtrate after the second extraction, and combine the first The filtrate after leaching and the filtrate after the second leaching are heated and concentrated to 200-250mL, and camphor is added to dissolve it.

The present invention also provides a kind of emulsifiable cream for treating frostbite, and its preparation method is, take 5-10 parts by weight of Asarum, 5-10 parts by weight of Bletilla striata, 5-10 parts by weight of Chuanjiao, 5-10 parts by weight of Guizhi of Guizhi, 5-10 parts by weight of Angelica dahurica, 5-10 parts by weight of Panax notoginseng, 5-10 parts by weight of raw rhubarb, 5-10 parts by weight of salvia miltiorrhiza, 5-10 parts by weight of Shengchuanwu, 5-10 parts by weight of 10 parts by weight of Aconitum aconitum, 10-20 parts by weight of raw licorice, and 10-20 parts by weight of genkwa are crushed, decocted, filtered, and the filtrate is collected. After concentration, add Tween-806mL, glycerin 10mL, and triethanolamine 2mL Heating to 70-80°C, mixing with 20 parts by weight of stearic acid and 40 parts by weight of white petrolatum heated to 70-80°C, cooling to 30-55°C, adding 8-10 parts by weight of calcined gypsum and 15 parts by weight ～30 parts by weight of camphor are mixed to get final product.

Preferably, the preparation method of the cream is that the amount of water added for decocting is 400-500 mL.

Preferably, the preparation method of the cream is as follows: decocting twice; decocting for the first time for 1-3 hours, and decocting for the second time for 0.6-1.5 hours.

Preferably, the calcined gypsum is calcined gypsum powder.

In other embodiments provided by the present invention, the preparation method of the cream is specifically made from the following raw materials in parts by weight:

Take the rest of the above-mentioned raw materials except camphor and calcined gypsum, add 400-500mL of water to decoct, decoct for 1-3 hours for the first time, collect the filtrate after the first decoction after filtering, collect the filter residue and decoct for the second time 40-90min, collect the filtrate after the second decoction after filtration, combine the filtrate after the first decoction and the filtrate after the second decoction, heat and concentrate to 120-150mL, add Tween-80 6mL, glycerin 10mL, three 2mL of ethanolamine is heated to 70-80°C, mixed with a solution obtained by heating 20 parts by weight of stearic acid and 40 parts by weight of white petrolatum to 70-80°C, and cooled.

The present invention also provides chilblain ointment, which is prepared by heating 400-800mL of animal oil to 100-120°C, adding 5-10 parts by weight of Herba Asarum, 5-10 parts by weight of Bletilla striata, 5-10 parts by weight of Sichuan pepper, 5-10 parts by weight of cassia twig, 5-10 parts by weight of Angelica dahurica, 5-10 parts by weight of Panax notoginseng, 5-10 parts by weight of raw rhubarb, 5-10 parts by weight of salvia miltiorrhiza, 5-10 parts by weight of The parts by weight of Aconitum aconiti, 5-10 parts by weight of Aconitum aconiti, 10-20 parts by weight of raw licorice, and 10-20 parts by weight of genkwa, are stirred and pressed for 30-50 minutes, cooled to 40-60°C, Add 15-30 parts by weight of camphor and 8-10 parts by weight of calcined gypsum, stir and cool to 20-30 DEG C to obtain the product.

Preferably, the animal oil is suet or lard.

Sheep oil is white or light yellow waxy solid with a relative density of 0.943-0.952. The melting point is 42-48°C. The iodine value is 38-42. Saponification value 194-199. The main ingredients are triglycerides of oleic acid, stearic acid and palmitic acid. It is made from fat-containing tissues near viscera and subcutaneous tissue of sheep, and is prepared by boiling. Used to make soap, stearic acid, glycerin, fatty alcohol, fatty amine, fatty acid, lubricating oil, etc. Fresh esters are refined for consumption. Sheep oil is mostly obtained by boiling the viscera and subcutaneous fat tissue of sheep.

Lard, also known as big oil or lard, is also called lard or big oil in Chinese, which is extracted from pork.

Preferably, the calcined gypsum is calcined gypsum powder.

The invention provides a traditional Chinese medicine composition, preparation, preparation method and application. The traditional Chinese medicine composition consists of 5-10 parts by weight of Asarum, 5-10 parts by weight of Bletilla striata, 5-10 parts by weight of Sichuan pepper, 5-10 parts by weight of cassia twig, 5-10 parts by weight of Angelica dahurica, 5-10 parts by weight of Baiji 10 parts by weight of notoginseng, 5-10 parts by weight of raw rhubarb, 5-10 parts by weight of salvia miltiorrhiza, 5-10 parts by weight of raw Chuanwu, 5-10 parts by weight of Shengcaowu, 10-20 parts by weight of Raw licorice, 15-30 parts by weight of camphor, 10-20 parts by weight of genkwa, and 8-10 parts by weight of calcined gypsum. The drug efficacy test shows that the traditional Chinese medicine composition and preparation chilblain tincture, chilblain cream and chilblain ointment provided by the invention can effectively cure chilblain.

Detailed ways

The invention discloses a traditional Chinese medicine composition, a clinical preparation and a preparation method. Those skilled in the art can refer to the content of this article to appropriately improve the process parameters to achieve. In particular, it should be pointed out that all similar replacements and modifications are obvious to those skilled in the art, and they are all considered to be included in the present invention. The method and application of the present invention have been described through preferred embodiments, and the relevant personnel can obviously make changes or appropriate changes and combinations to the method and application described herein without departing from the content, spirit and scope of the present invention to realize and Apply the technology of the present invention.

The medicinal materials in the present invention can be purchased from the market.

Below in conjunction with embodiment, further set forth the present invention:

Embodiment 1 prepares the Chinese medicine composition provided by the invention

Add the other raw materials except camphor into 600mL of water, stir and decoct for 30min, cool to 50°C, add camphor, stir and cool to 30°C to obtain the product.

Embodiment 2 prepares the Chinese medicine composition provided by the invention

Add the other raw materials except camphor into 1000mL water, stir and decoct for 60min, cool to 40°C, add camphor, stir and cool to 30°C to obtain the product.

Embodiment 3 prepares the Chinese medicine composition provided by the invention

Add the rest of the above-mentioned raw materials except camphor to 800mL water, stir and cook for 40 minutes, cool to 60°C, add camphor, stir and cool to 25°C, and collect the ointment.

Embodiment 4 prepares chilblain tincture provided by the invention

After taking the rest of the raw materials except camphor and pulverizing them, soak them in 250mL of 75% ethanol at 25°C for 10d or in a water bath at 50°C for 56h, filter and collect the filtrate after the first leaching; collect the filter residue, and use 250mL Soak in 60% ethanol at 25°C for 7 days or in a water bath at 50°C for 56 hours, collect the filtrate after the second leaching, combine the filtrate after the first leaching and the filtrate after the second leaching, heat and concentrate to 250mL, add camphor to dissolve, that is.

Embodiment 5 prepares chilblain tincture provided by the invention

After crushing the rest of the raw materials except camphor, soak in 200mL of 75% ethanol at 15°C for 15d or in a water bath at 50°C for 72h, filter and collect the filtrate after the first leaching; collect the filter residue, and use 200mL Soak in 60% ethanol at 15°C for 15 days or in a water bath at 50°C for 72 hours, collect the filtrate after the second leaching, combine the filtrate after the first leaching and the filtrate after the second leaching, heat and concentrate to 200mL, add camphor to dissolve, that is.

Embodiment 6 prepares chilblain tincture provided by the invention

After taking the rest of the raw materials except camphor and pulverizing them, soak them in 230mL of 75% ethanol at 40°C for 7d or in a water bath at 50°C for 48h, filter and collect the filtrate after the first leaching; collect the filter residue, and use 230mL Soak in ethanol with a concentration of 60% at 40°C for 7 days or in a water bath at 50°C for 48 hours, collect the filtrate after the second leaching, combine the filtrate after the first leaching and the filtrate after the second leaching, heat and concentrate to 220mL, add camphor to dissolve, that is.

Embodiment 7 prepares chilblain cream provided by the invention

Take the rest of the raw materials except camphor and calcined gypsum powder and pulverize them, add 400mL of water to decoct, decoct for 1 hour for the first time, collect the filtrate after the first decoction after filtering, collect the filter residue and decoct for the second time for 1.5 hours, After filtering, collect the filtrate after the second decoction, combine the filtrate after the first decoction and the filtrate after the second decoction, heat and concentrate to 120mL, add Tween-806mL, glycerin 10mL, triethanolamine 2mL and heat to 70°C, It is mixed with a solution obtained by heating 20 parts by weight of stearic acid and 40 parts by weight of white vaseline to 70° C., cooled to 30° C., adding camphor and calcined gypsum powder, and mixing to obtain the product.

Embodiment 8 prepares chilblain cream provided by the present invention

Take the rest of the raw materials except camphor and calcined gypsum powder and pulverize them, add 500mL of water to decoct, decoct for 3 hours for the first time, collect the filtrate after filtering for the first decoction, collect the filter residue and decoct for 0.6h for the second time, After filtering, collect the filtrate after the second decoction, combine the filtrate after the first decoction and the filtrate after the second decoction, heat and concentrate to 150mL, add Tween-806mL, glycerin 10mL, triethanolamine 2mL and heat to 80°C, It is mixed with a solution obtained by heating 20 parts by weight of stearic acid and 40 parts by weight of white vaseline to 80° C., cooled to 55° C., adding camphor and calcined gypsum powder, and mixing to obtain the product.

Embodiment 9 prepares chilblain cream provided by the invention

Take the rest of the above-mentioned raw materials except camphor and calcined gypsum, add 450mL of water to decoct, decoct for 2 hours for the first time, collect the filtrate after the first decoction after filtering, collect the filter residue and decoct for the second time for 1.2 hours, filter Then collect the filtrate after the second decoction, combine the filtrate after the first decoction and the filtrate after the second decoction, heat and concentrate to 135mL, add Tween-806mL, glycerin 10mL, triethanolamine 2mL and heat to 75 ° C, and 20 parts by weight of stearic acid and 40 parts by weight of white vaseline are mixed with a solution obtained by heating to 75° C., cooled to 45° C., adding camphor and calcined gypsum, and mixing to obtain the product.

Embodiment 10 prepares chilblain ointment provided by the invention

Heat the animal oil to 110°C, add the other raw materials except camphor and calcined gypsum powder into 800mL of the animal oil, stir and press for 30min, cool to 60°C, add camphor and calcined gypsum powder, stir and cool to 25°C , get the ointment.

Embodiment 11 prepares chilblain ointment provided by the invention

Heat the animal oil to 100°C, add the other raw materials except camphor and calcined gypsum powder into 400mL of the animal oil, stir and press for 50min, cool to 50°C, add camphor and calcined gypsum powder, stir and cool to 30°C , get the ointment.

Embodiment 12 prepares chilblain ointment provided by the invention

Heat the animal oil to 120°C, add the other raw materials except camphor and calcined gypsum into 600mL of the animal oil, stir and decoct for 40 minutes, cool to 40°C, add camphor and calcined gypsum, stir and cool to 30°C, collect Serve with ointment.

Embodiment 13 The drug efficacy test of Chinese medicine composition provided by the present invention, chilblain tincture, chilblain cream, chilblain ointment

In Northwest, Southwest, Northeast, North China, Southeast, and Central China, a total of 60 patients with chilblain were randomly selected from various industries, and the duration of the disease ranged from 1 to 52 years. They were divided into indoor and outdoor groups according to their occupations. 30 investigated patients; divided into male patients and female patients according to their genders. The chilblain patients were treated with the traditional Chinese medicine composition provided by Examples 1 to 3 of the present invention. The therapeutic effect is shown in Table 1.

Table 1 Chinese medicine composition provided by the present invention treats chilblain effect

As can be seen from the results in Table 1, the Chinese medicine composition provided by the present invention has a cure rate of 83.3% for indoor working patients, a markedly effective rate of 16.7%, and a total effective rate of 100%; the cure rate for outdoor working patients is 70%, and the markedly effective rate 30%. The cure rate of the traditional Chinese medicine composition provided by the invention is 84.2% for male patients, and the effective rate is 15.8%; the cure rate for female patients is 63.6%, the effective rate is 36.4%, and the total effective rate is 100%.

In Northwest, Southwest, Northeast, North China, Southeast, and Central China, a total of 60 chilblain patients of various ages were randomly selected, and the duration of the disease ranged from 1 to 48 years. They were divided into 2 groups according to age, and 7-19 years old One group, 20-69 years old as the second group, each group of 30 patients under investigation. The chilblain tincture provided by Examples 4 to 6 of the present invention is used to treat chilblain patients, and the therapeutic effects are shown in Table 2.

Table 2 chilblain tincture provided by the present invention treats chilblain effect

As can be seen from the results in Table 2, the chilblain tincture provided by the present invention has a cure rate of 100% for patients aged 7 to 19, a cure rate of 93.3% for patients aged 20 to 69, an effective rate of 6.7%, and a total effective rate of 100%. .

The chilblain cream provided by Examples 7 to 9 of the present invention was administered to 1000 chilblain patients, and the drug efficacy results are shown in Table 3.

Table 3 chilblain emulsifiable cream provided by the present invention treats chilblain effect

As can be seen from the results in Table 3, 1000 patients were divided according to gender, 349 cases of male patients, 651 cases of female patients, 343 cases of male patients were cured, 648 cases of female patients were cured, 991 cases were cured in total, the cure rate was 99.1%, and 9 cases were markedly effective. The apparent efficiency is 0.9%. Classified by age, 707 cases of patients aged 7-20 were cured, 707 cases were cured, and the cure rate was 100%; patients aged 21-70, a total of 293 cases were cured, 284 cases were cured, the cure rate was 96.9%, 9 cases were markedly effective, and the marked rate was 3.1%. According to the curing time, 433 cases were cured 2 to 3 days after application of the medicine, 500 cases were cured after 3 to 5 days, of which 933 cases were cured within 5 days, and 62 cases were cured after 3 to 5 days. According to the treatment parts, there were 627 patients with chilblain on the head and face, 627 cases were cured, and the cure rate was 100%; 248 patients with chilblain on the hands, 242 cases were cured, the cure rate was 97.58%, 6 cases were markedly effective, and the cure rate was 97.58%. The efficiency was 2.42%. Of the 125 patients with frostbite on the feet, 122 were cured, with a cure rate of 97.6%. 3 cases were markedly effective, with a marked rate of 2.4%. The total effective rate is 100%.

In Northwest, Southwest, Northeast, North China, Southeast, and Central China, a total of 60 patients with chilblain were randomly selected from various industries, and the duration of the disease ranged from 1 to 52 years. They were divided into indoor and outdoor groups according to their occupations. 30 patients were investigated; according to gender, they were divided into two groups: male patients and female patients. The chilblain ointment provided in Examples 10 to 12 of the present invention was used to treat chilblain patients, and the results are shown in Table 4.

Therapeutic effect of table 4 Chilblain ointment on Chilblain patients

As can be seen from the table 4 results, the chilblain ointment provided by the present invention has a 100% cure rate to the indoor work patient; the cure rate to the outdoor work patient is 96.6%, and the effective rate is 3.4%, and the total effective rate is 100%. The cure rate of chilblain ointment provided by the invention is 100% for male patients; the cure rate for female patients is 94.7%, the effective rate is 5.3%, and the total effective rate is 100%.

Example 14 The Chinese medicine composition for the treatment of chilblain provided by the present invention, chilblain tincture, chilblain cream and chilblain ointment for treating chilblain

Case 1:

Name: Miao, Gender: Male, Age: 40 years old, Visited on January 3, 2009, Worked as a loading and unloading worker at a pharmaceutical company in Suzhou, engaged in indoor and outdoor transportation for a long time, and had multiple chilblains on the face, ears, and fingers. The affected area was red, swollen and itchy, and the hands were scratched and inflamed due to itching. During this period, various chilblain ointments were used, but the effect was not satisfactory. Applying the chilblain tincture provided in Example 4 of the present invention, the itching stopped after 3 minutes of application , the symptoms disappeared after 3 days.

Case 2:

Full name: Zhu, sex: male, age: 56 years old, the time of seeing a doctor on December 7th, 2010, the teacher of Gulou Elementary School in Shicun Township, because the hands were frozen to death, applied the chilblain tincture provided by the embodiment of the present invention 5, 2 After 2 days, the mouth that was rotted by freezing closed up, and recovered after 5 days, leaving only traces of pigment.

Case 3:

Name: Ma, gender: male, age: 42 years old, visited on December 23, 2010, a construction worker in Madazhuang Village, Shicun Town, Suzhou City. The itching has been scratched and rotten. Before coming to our place, some medicines for treating chilblain were used, but no improvement was seen. Applying the chilblain tincture provided in Example 6 of the present invention, the itching stopped in 2 days, the lump disappeared substantially in 5 days, and all symptoms disappeared after 7 days. has disappeared.

Case 4:

Name: Chen, gender: female, age: 39 years old, visited on January 5, 2011, a worker at Nanguan Spinning Mill in Suzhou, who had pimples in many places on his face, and felt pain and heat, and applied the embodiment of the present invention 7 The chilblain ointment provided, the pain and heat disappeared in 5 minutes, the above symptoms all disappeared after 3 days, and fully recovered after 7 days.

Case 5:

Name: Li, Gender: Female, Age: 38 years old, Visited on December 8, 2010, owner of a vegetable wholesaler in Beiyuan Community, Suzhou City, had chilblains and festered areas on his face, hands, and back, every year until winter All by frostbite, once used several kinds of chilblain creams, the effect is unsatisfactory, apply the chilblain cream that the embodiment of the present invention 8 provides, 3 days ulceration place heals, fully recovers after 7 days.

Case 6:

Name: Wu Huaying, Gender: Male, Age: 38 years old, Visited on November 29, 2009, from Daying Town, Suzhou City, construction project manager. There was a chilblain on each side of the face, which was slightly festered and blackened. With the chilblain cream provided by the embodiment of the present invention 9, ulceration disappeared after 3 days. After 5 days, the face basically returned to normal, leaving only a little pigmentation.

Case 7:

Name: Hu Mou, Gender: Male, Age: 40 years old, Visited on November 2, 2008, manager of the Dongxianqiao Chess Room in Suzhou City, had chilblain on the face and hands for many years and itching and pain in winter, and used several times A kind of chilblain ointment is all unsatisfactory, just recurs in winter, applies the Chinese medicine composition for the treatment of chilblain that the embodiment of the present invention 1 provides, just fully recovers after 4 days, does not have recurrence through following up a case by regular visits to in 2 years.

Case 8:

Name: Li, Gender: Male, Age: 50 years old, Visited on November 27, 2007, Manager of the sales department of Suzhou Food Company, due to long-term motorcycle sales, resulting in frostbite on the face, ears, hands, etc. , festering, itching, pain, and heat are all present, and they are protected in advance every year, and they still recur. Apply chilblain ointment provided by the embodiment of the present invention 10, after smearing 2 days, symptom alleviates, after 7 days all symptoms disappear, follow up a case by regular visits to and do not have recurrence for three years.

Case 9:

Name: Ma, Gender: Male, Age: 7 years old, Visited on December 4, 2009, a second-grade student at No. 12 Primary School in Suzhou City. The child often played outside, resulting in frostbite on the face and hands, and festering. Apply chilblain ointment that the embodiment of the present invention 11 provides, 2 days fester place just healed, and after 5 days, symptom disappears, and fully recovers after 7 days.

Case 10:

Name: Wang Yan, Gender: Female, Age: 23 years old, visited on December 9, 2008, an accountant of Suzhou Power Supply Company, since she was young, she had frozen roots on her hands and feet, and had chilblains every winter. Over the years, several chilblain ointments had no effect. After applying the chilblain ointment provided in Example 12 of the present invention, the itching of the affected area was relieved in 3 days, and the symptoms were alleviated. After 7 days, the symptoms disappeared substantially, and there was no recurrence in 2 years of follow-up.

The above is only a preferred embodiment of the present invention, it should be pointed out that, for those of ordinary skill in the art, without departing from the principle of the present invention, some improvements and modifications can also be made, and these improvements and modifications can also be made. It should be regarded as the protection scope of the present invention.

Claims (10)

1. a Chinese medicine composition for the treatment of frostbite, is characterized in that, is made of following raw materials in parts by weight:

2. A clinical preparation, characterized in that it consists of the traditional Chinese medicine composition according to claim 1 and pharmaceutically acceptable adjuvants. 3. The clinical preparation according to claim 2, characterized in that it is a tincture, a cream or an ointment. 4. A preparation method of a Chinese medicine composition for the treatment of frostbite, characterized in that, 5-10 parts by weight of Asarum, 5-10 parts by weight of Bletilla striata, 5-10 parts by weight of Chuanjiao, 5-10 parts by weight of Guizhi of Guizhi, 5-10 parts by weight of Angelica dahurica, 5-10 parts by weight of Panax notoginseng, 5-10 parts by weight of raw rhubarb, 5-10 parts by weight of salvia miltiorrhiza, 5-10 parts by weight of Shengchuanwu, 5-10 parts by weight of 10 parts by weight of Aconitum aconitum, 10-20 parts by weight of raw licorice, 10-20 parts by weight of genkwa, and 8-10 parts by weight of calcined gypsum, after stirring, add 600-1000mL water to decoct for 30-60min, cool to 40-60°C, add 15-30 parts by weight of camphor, stir and cool to 20-30°C to obtain. 5. the Chinese medicine composition prepared according to the described preparation method of claim 4. 6. A tincture for treating frostbite, characterized in that its preparation method is to get 5-10 parts by weight of Asarum, 5-10 parts by weight of Bletilla striata, 5-10 parts by weight of Chuanjiao, 5-10 parts by weight of Guizhi, 5-10 parts by weight of Angelica dahurica, 5-10 parts by weight of Panax notoginseng, 5-10 parts by weight of raw rhubarb, 5-10 parts by weight of salvia miltiorrhiza, 5-10 parts by weight of Shengchuanwu, 5-10 parts by weight Aconitum aconiti in parts by weight, 10-20 parts by weight of raw licorice, 10-20 parts by weight of Daphne genkwa, and calcined gypsum of 8-10 parts by weight are pulverized, and then 200-250 mL of concentration is 75% and 60% ethanol Leaching, adding 15 to 30 parts by weight of camphor and mixing to obtain. 7. The tincture according to claim 6, characterized in that the leaching in the preparation method is soaking at 15-40°C for 7-15 days or soaking at 50°C for 48-72 hours in a water bath. 8. A cream for treating frostbite, characterized in that its preparation method is to take 5-10 parts by weight of Asarum, 5-10 parts by weight of Bletilla striata, 5-10 parts by weight of Chuanjiao, 5-10 parts by weight of Guizhi of Guizhi, 5-10 parts by weight of Angelica dahurica, 5-10 parts by weight of Panax notoginseng, 5-10 parts by weight of raw rhubarb, 5-10 parts by weight of salvia miltiorrhiza, 5-10 parts by weight of Shengchuanwu, 5-10 parts by weight of 10 parts by weight of Aconitum aconitum, 10-20 parts by weight of raw licorice, and 10-20 parts by weight of genkwa are crushed, decocted, filtered, and the filtrate is collected. After concentration, add Tween-806mL, glycerin 10mL, and triethanolamine 2mL Heating to 70-80°C, mixing with 20 parts by weight of stearic acid and 40 parts by weight of white petrolatum heated to 70-80°C, cooling to 30-55°C, adding 8-10 parts by weight of calcined gypsum and 15 parts by weight ～30 parts by weight of camphor are mixed to get final product. 9 . The cream according to claim 8 , wherein the decocting is decocting by adding 400-500 mL of water respectively; the first decoction is 1-3 hours, and the second decoction is 0.6-1.5 hours. 10. A chilblain ointment, characterized in that the preparation method is to heat 400-800mL of animal oil to 100-120°C, add 5-10 parts by weight of Asarum, 5-10 parts by weight of Bletilla striata, 5-10 parts by weight of 5-10 parts by weight of Sichuan pepper, 5-10 parts by weight of cassia twig, 5-10 parts by weight of Angelica dahurica, 5-10 parts by weight of Panax notoginseng, 5-10 parts by weight of raw rhubarb, 5-10 parts by weight of salvia miltiorrhiza, 5-10 parts by weight of Stir 10 parts by weight of raw Aconitum aconitum, 5-10 parts by weight of Aconitum aconiti, 10-20 parts by weight of raw licorice, and 10-20 parts by weight of genkwa, decoct and squeeze for 30-50 minutes, and cool to 40-60 ° C. Add 15-30 parts by weight of camphor and 8-10 parts by weight of calcined gypsum, stir and cool to 20-30 DEG C to obtain the product.