CN101862384B

CN101862384B - External medicament for treating leucoderma

Info

Publication number: CN101862384B
Application number: CN2010101083215A
Authority: CN
Inventors: 杨晓陆
Original assignee: Individual
Current assignee: Individual
Priority date: 2010-02-04
Filing date: 2010-02-04
Publication date: 2011-08-17
Anticipated expiration: 2030-02-04
Also published as: CN101862384A

Abstract

The present invention discloses a medicament, and in particular relates to an external use medicament for treating leucoderma, which comprises the following medicaments of 15 to 25 grams of impatiens balsamina, 45 to 55 grams of Chinese gall, 45 to 55 grams of pomegranate rind, 25 to 35 grams of dark plum fruit, 45 to 55 grams of malaytea scurfpea fruit, 4 to 6 grams of musk, 45 to 55 grams of angelica dahurlica, 65 to 75 grams of tribulus fruit, 65 to 75 grams of prepared radix polygoni multiflori, 45 to 55 grams of pubescent angelica root and 45 to 55 grams of flastem milkvetch seed. A preparation method of the medicament comprises the following steps of: removing impurities from the medicaments; cleaning the medicaments by using clear water; fishing out the cleaned medicaments for drying in the sun; drying the dried medicaments over slow fire; pulverizing and mixing the dried medicaments uniformly; immersing the mixed medicaments in 1,500 milliliters of 60 percent alcohol for 15 days; and filtering to obtain solution. Because in the medicament, 11 efficient medicaments are utilized, the medicament has the effects of warming skin and eliminating cold, dispelling the wind and eliminating dampness, relaxing muscles and activating collaterals and promoting blood circulation and removing blood stasis, can improve the microcirculation of skin at the lesion site, replenish trace elements directly, increase the photosensitization of the skin, activate the activity of tyrosinase, promote the synthesis of melanin in the skin and increase chromatosis, and has the advantages of scientific and reasonable formula, harmonious medicaments, good curative effect, low relapse rate, no toxic or side effect and obvious treatment effect.

Description

The leukodermic external used medicine of a kind of treatment

Technical field: the present invention relates to a kind of Chinese medicine, specifically is the leukodermic external used medicine of a kind of treatment.

Background technology: vitiligo is a kind of common, refractory skin, though entail dangers to life has not had a strong impact on patient's image, employment, marriage, destroys mental health, even directly destroys patient's dream, brings very big psychic pain to patient.Vitiligo is a kind of primary cutaneous depigmentation disease, although pathogenic factor is very complicated, but it is the local epidermis intersection melanocyte tryrosinase systemic-function forfeiture of infringement that scientific practice has confirmed pathogeny, tyrosine can not be oxidized to dihydroxyphenylalanine (DoPa) thereby make melanocyte form obstacle, also pile up just like hydrogen peroxide, lack trace copper, zinc, it is synthetic that factors such as ultraviolet heredity, immunity, medicine all can influence melanin.Leukodermic method of treatment and medicine are various at present, usually whole body therapeutic is used heavy metal or hormonal medicaments treatment, because of containing hormone or heavy metal composition, the autopath is more, and life-time service easily causes the skin aging fibrosis, and most curative effects can not be satisfactory, and treat with high costsly, and general patient is difficult to bear.

Summary of the invention: the present invention has eliminated the drawback that former treatment vitiligo medicine exists, a kind of fine activation tryrosinase of Chinese medicine that utilizes is provided, enhancing is to ultraviolet photosensitization, contain various trace elements, promote melanic synthetic, and good effect, the leukodermic external used medicine of a kind of treatment that has no side effect.The technical solution adopted in the present invention is: described medicine is made by following crude drug: Flos Impatientis 15-25g, Galla Chinensis 45-55g, Pericarpium Granati 45-55g, Fructus Mume 25-35g, Fructus Psoraleae 45-55g, Moschus 4-6g, Radix Angelicae Dahuricae 45-55g, Fructus Atriplicis Sibiricae 65-75g, Radix Polygoni Multiflori Preparata 65-75g, Radix Angelicae Pubescentis 45-55g, Semen Astragali Complanati 45-55g; The preparation method of described medicine is for to choose decontamination with the above-mentioned raw materials medicine, and clear water is cleaned, and pulls out, dries, and slow fire dries, and grinds, and mixing is put together, with 1500 milliliters of 60% ethanol, soaks 15, filters and promptly gets solution.

Pharmacology analysis of the present invention: works such as motherland's medical science " all cause of disease wait opinion ", Golden Mirror of Medicine, " Standards of Diagnosis and Treatment ", to discuss vitiligo is existing, summary is thought the skin QI and blood deficiency, the qi-blood disharmony damp-stagnancy that becomes a common practice is due to the fur.In recent years, fast development along with the modern medicine technology, for probing into the leukodermic cause of disease, scientists is constantly from the physiology of human body skin, biological, biochemical, heredity, deep research is carried out in aspects such as immune molecule and cell division and cycle variation and trace element, find that tryrosinase is the synthetic key enzyme of melanin, be considered to the autoimmune important antigen of vitiligo, and the pathology reason that causes skin pigment to take off mistake is that the tryrosinase of human body is suppressed, cause functional melanocyte to be subjected to destroy to some extent, and then cause the melanin metabolic process to be obstructed.Chinese medicine thinks that leucoderma disease is many because of internal injury caused by excess of seven emotions, depression of liver-QI, and functional activity of QI being not smooth is felt ailment said due to cold or exposure again, and obstruction of meridian forms; Or because the natural endowment deficiency, caused by liver and kidney deficiency, deficient qi and blood can not nourish skin and make toxin build up with the passing of time to send out in body surface to form.

The present invention be with form through clinical screening for many years through proved recipe, its characteristics are to improve the microcirculation of lesions position skin, increase the photosensitization of skin, activity of tyrosinase, promote in the skin melanic synthetic, increase pigmentation, stimulate melanocyte to make its restore funcitons, thereby make the skin melanin regeneration.Flos Impatientis in the described prescription, bitter in the mouth, suffering, warm in nature have that blood stasis expelling stimulates the menstrual flow, hard masses softening and resolving, the effect that promotes drug absorption are arranged; Galla Chinensis contains gallic acid, and protein is had precipitation, can make the mucocutaneous ulcer face get histone and solidify, and causes one deck tunicle and is astriction, makes the oppressed contraction of little blood vessel and stops blooding, and has the effect that convergence is astringent or styptic treatment for spontaneous sweating, skin ulcer is treated in detoxifcation; Pericarpium Granati, sour in the mouth is puckery, warm in nature; Contain tannin, various bacteria, fungus and influenza virus are had inhibitory action, have relieving diarrhea with astringents, killing parasites for relieving itching, the effect of hemostasis leukorrhagia stopping; Fructus Mume, sour in the mouth, puckery, property is flat; Has the effect that astringing lung-QI and relieving cough, relieving diarrhea with astringents, promoting the production of body fluid to quench thirst, relieving colic caused by ascaris, hemostasis, detumescence are held back skin ulcer and enhance immunity; Fructus Psoraleae, warm in nature, acrid in the mouth, hardship.Contain flavone compound, Coryfolin, Coumarins chemical compound, Radix Angelicae Dahuricae element, Bakuchiol and volatilization wet goods.Can strengthen skin to ultraviolet sensitivity, obvious coronary artery dilator, promote the granulocyte growth, promote the metabolism of dermal melanin, make cutaneous pigmentation, promote the synthetic increase of melanocyte, increased functionality, the expansion local vascular improves histotrophic nutrition, has the effect of kidney invigorating and YANG supporting, helping inspiration to relieve asthma, warm spleen antidiarrheal; Moschus has the refreshment of having one's ideas straightened out, the eliminating carbuncle of invigorating blood circulation, eliminating stasis to stop pain, expedites the emergence of down tire, expansion local vascular, microcirculation improvement and antiphlogistic effect; The Radix Angelicae Dahuricae, acrid in the mouth, warm in nature contains furocoumarin, can improve skin to ultraviolet light sensitivity, improve local blood circulation, eliminate hydrogen peroxide and in tissue, excessively pile up, promote the melanocyte metabolism, increase the epidermis melanin content, has wind-expelling pain-stopping, clearing the nasal passage, subduing inflammation, the effect of skin moistening and itch stopping; Fructus Atriplicis Sibiricae, warm in nature, bitter in the mouth, suffering contain multiple alkaloid, glycoside, fatty oil, volatile oil and multiple abundant peroxidase tannin etc., have vessel softening, strengthen microcirculation, defying age, make eye bright and make light of one's life by commiting suicide, the effect of cicatrix on the removal face; Radix Polygoni Multiflori Preparata, bitter in the mouth, sweet, puckery has liver and kidney tonifying, nourishes essence and blood, loosening bowel to relieve constipation, the effect of detoxifying and relieving itching; Radix Angelicae Pubescentis, acrid in the mouth, bitter, warm in nature, the xanthoxlin that contains, bergapton, the flavor that ammidin etc. have the photosensitization coumarin substances of muttering, can improve skin to ultraviolet sensitivity, suppress the sulfydryl in the epidermis, strengthen tyrosinase activity, its function of stimulation melanin cellular-restoring, melanin formation promoting etc., thereby make the regeneration of white macula pigment and the leukodermic effect of treatment is arranged, especially the calmness of Radix Angelicae Pubescentis, functions such as hypnosis can reduce patient's thinking activities, alleviate the mental pressure that causes because of disease, has positive facilitation to stablizing the state of an illness, and has expelling wind and dampness, pain relieving, the effect of the cold expelling that induces sweat; Semen Astragali Complanati has the solid warp of the kidney invigorating, the effect of nourishing the liver to improve visual acuity, and being used for the treatment of vitiligo has curative effect preferably.Above-mentioned substance can play adjusting cells physiological, biochemical action rapidly after entering Cytoplasm, activates tryrosinase, impels melanocyte to recover normal physiological function, thereby reaches the leukodermic purpose of treatment.

The invention has the beneficial effects as follows: owing to utilize 11 kinds of efficient medicines, have warm skin cold expelling, dispeiling pathogenic wind and removing dampness, soothing the channels and quicking the network vessels, the effect of blood circulation promoting and blood stasis dispelling can be improved the microcirculation of lesions position skin, directly trace element supplement, increase the photosensitization of skin, activity of tyrosinase promotes melanic synthesizing in the skin, increases pigmentation.Scientific formulation is reasonable, and each medicine is in step with, and good effect, relapse rate are low, have no side effect, and therapeutic effect is remarkable.

The specific embodiment: embodiment 1: described medicine is made by following crude drug: Flos Impatientis 15-25g, Galla Chinensis 45-55g, Pericarpium Granati 45-55g, Fructus Mume 25-35g, Fructus Psoraleae 45-55g, Moschus 4-6g, Radix Angelicae Dahuricae 45-55g, Fructus Atriplicis Sibiricae 65-75g, Radix Polygoni Multiflori Preparata 65-75g, Radix Angelicae Pubescentis 45-55g, Semen Astragali Complanati 45-55g; The preparation method of described medicine is for to choose decontamination with the above-mentioned raw materials medicine, and clear water is cleaned, and pulls out, dries, and slow fire dries, and grinds, and mixing is put together, with 1500 milliliters of 60% ethanol, soaks 15, filters and promptly gets solution.

Embodiment 2: described medicine is the medicament that is prepared from by following materials of weight proportions medicine: Flos Impatientis 20g, Galla Chinensis 50g, Pericarpium Granati 50g, Fructus Mume 30g, Fructus Psoraleae 50g, Moschus 5g, Radix Angelicae Dahuricae 50g, Fructus Atriplicis Sibiricae 70g, Radix Polygoni Multiflori Preparata 70g, Radix Angelicae Pubescentis 50g, Semen Astragali Complanati 50g; The preparation method of described medicine is for to choose decontamination with said medicine, and clear water is cleaned, and pulls out, dries, and slow fire dries, and grinds, and mixing is put together, with 1500 milliliters of 60% ethanol, soaks 15, filters and promptly gets solution.

Embodiment 3: described preparation method is for to choose decontamination with crude drug Flos Impatientis 15-25g, Galla Chinensis 45-55g, Pericarpium Granati 45-55g, Fructus Mume 25-35g, Fructus Psoraleae 45-55g, Radix Angelicae Dahuricae 45-55g, Fructus Atriplicis Sibiricae 65-75g, Radix Polygoni Multiflori Preparata 65-75g, Radix Angelicae Pubescentis 45-55g, Semen Astragali Complanati 45-55g, clear water is cleaned, pull out, dry, dry with slow fire then, grind standby; The 4-6g Moschus is soaked into warm water again, sever sachet, remove fur, inner membrance and impurity, it is standby to be ground into thin foam; At last the above-mentioned crude drug mixing that processes is put together,, soaked 15, filter and promptly get solution with 1500 milliliters of 60% ethanol.

Embodiment 4: described preparation method is for to choose decontamination with crude drug Flos Impatientis 20g, Galla Chinensis 50g, Pericarpium Granati 50g, Fructus Mume 30g, Fructus Psoraleae 50g, Radix Angelicae Dahuricae 50g, Fructus Atriplicis Sibiricae 70g, Radix Polygoni Multiflori Preparata 70g, Radix Angelicae Pubescentis 50g, Semen Astragali Complanati 50g, clear water is cleaned, pull out, dry, dry with slow fire then, grind standby; The 5g Moschus is soaked into warm water again, sever sachet, remove fur, inner membrance and impurity, it is standby to be ground into thin foam; At last the above-mentioned crude drug mixing that processes is put together,, soaked 15, filter and promptly get solution with 1500 milliliters of 60% ethanol.

Embodiment 5: the leukodermic medication preparation of described treatment becomes exterior-applied formulation, and using method is for can directly smear the affected part, and every day 2～3 times, consumption is decided on the size of skin lesion, and administration time is with till smearing the affected part and taking on a red color.

Embodiment 6: the present invention in the past few years treats patients with vitiligo 35 examples altogether, and through clinical observation, contrast proves that it is evident in efficacy, now selects case as follows at random:

Zhao Haijun, the man 53 years old, once worked at the Weihui City refractory factory.Do not know work relationship or poor sleep in March, 2006, gone out white macula on the face suddenly, see the doctor for treatment with that, can always not feel any better, oneself also buy the medicine treatment, once used quick White Dew of France, but medication is effective, a drug withdrawal just enlarges, the utmost point of tangible disappointment.Hear of good that Yang doctor controls at last, come and have a try, I had never expected the liquid medicine of smearing through two weeks, curative effect just occurred, it is a greater part of just to have taken a turn for the better with two months continuously, adheres to altogether having used six months, white patch on the face all disappears, the also blackening of white hair, as obtaining for second youth, gratified especially.

Embodiment 7: Zhang Fengzhi, the woman, 43 years old, live the Hebi City Heshan District, in June, 2007 is because of doing hysteromyoma operation, by the doctor enjoin eaten the VC sheet of a wheat harvesting period after, August, a lot of white maculas appearred in many places on one's body, begin not take notice of, I had never expected that color shoals gradually, to such an extent as to, all do not feel any better with many side's medicines at last as blank sheet of paper, looked for Yang doctor to be seen the most afterwards, but Yang doctor has only given down one bottle " water ", does not just smear, as a result behind the first quarter moon with entertaining hope everyday, be surprised to find the fritter white macula and disappear, large-area also have the trend of dwindling.What therefore just begin to note very much has smeared, and I had never expected that this bottle " water " allows the own spirit and the human body obtain " liberation ", just fully recovers in 3 months as a result, has and gain the sensation of living again happily, really thanks to Yang doctor!

Embodiment 8: Li Zengxi, and the man sees the doctor for treatment in many ways because of suffering from the large tracts of land vitiligo 23 years old this year, poor effect, and area day by day enlarges, even feed through to cervical region.Once looked for Yang doctor to see before more than ten years,,, sought medical advice carelessly everywhere, caused the result that today, the state of an illness increased the weight of owing to wait for information advertising though effect is pretty good.Yang doctor buries the past, and has opened medicine for external use to oneself, smears significant effective behind the first quarter moon, alleviates more than half part in 3 months, adheres to having fully recovered with 6 months.Really thanked to Yang doctor very much, oneself felt, really thanked very much as recapturing sunlight!

Claims

1. the leukodermic external used medicine of treatment is characterized in that described medicine made by following crude drug: Flos Impatientis 15-25g, Galla Chinensis 45-55g, Pericarpium Granati 45-55g, Fructus Mume 25-35g, Fructus Psoraleae 45-55g, Moschus 4-6g, Radix Angelicae Dahuricae 45-55g, Fructus Atriplicis Sibiricae 65-75g, Radix Polygoni Multiflori Preparata 65-75g, Radix Angelicae Pubescentis 45-55g, Semen Astragali Complanati 45-55g; The preparation method of described medicine is for to choose decontamination with the above-mentioned raw materials medicine, and clear water is cleaned, and pulls out, dries, and slow fire dries, and grinds, and mixing is put together, with 1500 milliliters of 60% ethanol, soaks 15, filters and promptly gets solution.

2. as the leukodermic external used medicine of claims 1 described a kind of treatment, it is characterized in that described medicine is the medicament that is prepared from by following materials of weight proportions medicine: Flos Impatientis 20g, Galla Chinensis 50g, Pericarpium Granati 50g, Fructus Mume 30g, Fructus Psoraleae 50g, Moschus 5g, Radix Angelicae Dahuricae 50g, Fructus Atriplicis Sibiricae 70g, Radix Polygoni Multiflori Preparata 70g, Radix Angelicae Pubescentis 50g, Semen Astragali Complanati 50g; The preparation method of described medicine is for to choose decontamination with the above-mentioned raw materials medicine, and clear water is cleaned, and pulls out, dries, and slow fire dries, and grinds, and mixing is put together, with 1500 milliliters of 60% ethanol, soaks 15, filters and promptly gets solution.

One kind the treatment leukodermic external used medicine preparation method, it is characterized in that described preparation method is for to choose decontamination with crude drug Flos Impatientis 15-25g, Galla Chinensis 45-55g, Pericarpium Granati 45-55g, Fructus Mume 25-35g, Fructus Psoraleae 45-55g, Radix Angelicae Dahuricae 45-55g, Fructus Atriplicis Sibiricae 65-75g, Radix Polygoni Multiflori Preparata 65-75g, Radix Angelicae Pubescentis 45-55g, Semen Astragali Complanati 45-55g, clear water is cleaned, pull out, dry, dry with slow fire then, grind standby; The 4-6g Moschus is soaked into warm water again, sever sachet, remove fur, inner membrance and impurity, it is standby to be ground into thin foam; At last the above-mentioned crude drug mixing that processes is put together,, soaked 15, filter and promptly get solution with 1500 milliliters of 60% ethanol.

4. preparation method as the leukodermic external used medicine of right 3 described treatments, it is characterized in that described preparation method is for to choose decontamination with crude drug Flos Impatientis 20g, Galla Chinensis 50g, Pericarpium Granati 50g, Fructus Mume 30g, Fructus Psoraleae 50g, Radix Angelicae Dahuricae 50g, Fructus Atriplicis Sibiricae 70g, Radix Polygoni Multiflori Preparata 70g, Radix Angelicae Pubescentis 50g, Semen Astragali Complanati 50g, clear water is cleaned, pull out, dry, dry with slow fire then, grind standby; The 5g Moschus is soaked into warm water again, sever sachet, remove fur, inner membrance and impurity, it is standby to be ground into thin foam; At last the above-mentioned crude drug mixing that processes is put together,, soaked 15, filter and promptly get solution with 1500 milliliters of 60% ethanol.