CN103041042B - Tibetan medicine composition and application of composition in anti-off hair products - Google Patents
Tibetan medicine composition and application of composition in anti-off hair products Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition. Aiming at the defect of obvious side effect of widely used anti-off hair products with chemical medicaments as effective ingredients in the prior art, the invention provides a Tibetan medicine composition and an application of the composition in anti-off hair products. The Tibetan medicine composition comprises the following components in parts by weight: 30-90 parts of phyllanthus emblica, 15-45 parts of radix rehmanniae preparata, 10-30 parts of fructus chebulae, 10-30 parts of peach seed, 10-30 parts of semen sesami nigrum, 5-15 parts of semen juglandis, 5-15 parts of radix salviae miltiorrhizae, 5-15 parts of semen cassia and 5-15 parts of agilawood. The pharmaceutical composition is based on antioxidant efficacy provided by fructus chebulae, radix rehmanniae preparata and emblic leafflower fruit as anti-off hair effect and is matched up with other medicament components with pharmacological activities such as activating blood and removing blood stasis, improving blood circulation, resisting germ and diminishing inflammation. The obtained composition has anti-off hair effect to hair-loss patients of various age structures through human clinic trial evidence. The composition is safe and reliable in medicinal material and original medicine and preparation method, is applied to anti-off hair with remarkable efficacy, short course of treatment and no toxic or side effect.
Description
Technical field
The present invention relates to a kind of compositions, particularly relate to a kind of Tibetan medicinal composition and the application in phalacrosis prevention and hair generation product thereof.
Background technology
Alopecia refers to obvious hair exception or excessive coming off, and belongs to the category such as alopecia areata, seborrheic alopecia in modern medicine.Its clinical symptoms main manifestations is that hair is greasy, as apply grease; Also have hair shrivelled, lack gloss, and have faint yellow squama set difficulty de-, or canescence squama is flown upward, and with scratchiness etc., has a strong impact on the image of patient, even causes very large mental pressure.Alopecia etiology unknown, modern medicine thinks relevant with spiritual hypertonicity, endocrine disturbance, malnutrition and dysbolism, immunity degradation, inherited genetic factors, fungal infection, radiation, chronic poisoning and the factor such as excessively to lose weight mostly.Traditional medicine is thought, the main focus of alopecia is deficiency of the liver and kindey, sends out to lose blood foster, and hair is the sign of blood condition, vim and vigour are contained, and send out and then moisten black, its means of prevention is blood-supplementing blood-nourishing.
Treatment product at present for phalacrosis prevention and hair generation mainly contains chemicals, Chinese medicine preparation and cosmetics etc.Wherein main chemicals has finasteride tablet and the minoxidil solution for the treatment of male pattern alopecia, the former finasteride is II type 5-alpha reductase inhibitor, dihydrotestosterone is converted into by suppressing testosterone specifically, reduce the content of dihydrotestosterone in scalp hair follicles, scalp hair follicles is suppressed to diminish, reverse hair loss process; While dihydrotestosterone content reduces in the scalp, in blood, dihydrotestosterone content reduces equally, causes occurring that a series of bad is answered, and mainly comprises feminization and depression etc.; And the latter's minoxidil solution is K ~+Channel Opener, can directly relax vascular smooth muscle, expansion small artery; Scalp is smeared in external, can promote scalp blood circulation, improves hair blood supply for oxygen condition, plays the effect promoting hair growth promoting; Simultaneously also can by hair follicle stimulating epithelial cell proliferation and differentiation, promote angiopoietic effect and hair growth.Though the effect of minoxidil solution hair growth certainly, needs heavy dose of and life-time service, can produce many side effect, mainly comprise water-sodium retention, blood pressure drops etc.Generally, be that the phalacrosis prevention and hair generation product of effectiveness composition has obvious side effect with chemicals, and need life-time service just to become effective.Chinese medicine preparation and be that the adornment font size phalacrosis prevention and hair generation product category that primary raw material is made is more with traditional medicine, have certain phalacrosis prevention and hair generation effect, its obvious advantage is that safety is good, side effect is little, but responding time is still longer.
Summary of the invention
It take Tibetan medicine as the compositions of raw material components that object of the present invention is just to provide a kind of, and said composition can be applied to the preparation of phalacrosis prevention and hair generation product.
For achieving the above object, technical scheme of the present invention is as follows:
A kind of Tibetan medicinal composition, is characterized in that: comprise Fructus Phyllanthi 30 ~ 90 parts by weight, Fructus Terminaliae Billericae 15 ~ 45 parts, Fructus Chebulae 10 ~ 30 parts, 10 ~ 30 parts, Semen Persicae, Semen Sesami Nigrum 10 ~ 30 parts, Semen Juglandis 5 ~ 15 parts, Radix Salviae Miltiorrhizae 5 ~ 15 parts, Semen Cassiae 5 ~ 15 parts, Lignum Aquilariae Resinatum 5 ~ 15 parts.
In above-mentioned Tibetan medicinal composition:
Fructus Phyllanthi, Tibetan language name is for a long time as drawn, be the dry mature fruit of Euphorbiaceae phyllanthus emblica platymiscium Fructus Phyllanthi (Phyllanthus emblica L.), be recorded in version " Yunnan Province's drug standard ", versions " Tibetan medicine standard " in 1978 in 1974 and go through an edition Pharmacopoeia of the People's Republic of China.Fructus Phyllanthi is Tibetan's conventional crude drugs, and primary efficacy is clearing away heat and cooling blood, promoting digestion and invigorating the stomach, cough-relieving of promoting the production of body fluid, for heat in blood blood stasis, and liver-gallbladder disease, dyspepsia, stomachache, cough, laryngalgia, xerostomia.Present medical discovery its according to having antioxidation, defying age, anti-cancer, anticancer, antibacterial, antiinflammatory, lowering blood-fat and reducing weight and atherosclerosis, and blood pressure lowering, assimilation, blood sugar lowering and improve the pharmacological actions such as diabetic complication.
Fructus Terminaliae Billericae, Tibetan language name handkerchief meat draws, and be the dry mature fruit that Combretum Racemosum plant adjoins Li Le (Terminalia billerica (Gaertn.) Roxb.), be Tibetan's conventional crude drugs, primary efficacy is heat-clearing and toxic substances removing, and convergence is nourished blood, coordinating the actions of various ingredients in a prescription.For various heat symptom-complex, dysentery, grasserie, liver-gallbladder disease is weak after being ill.
Fructus Chebulae is the dry mature fruit of Combretum Racemosum plant Fructus Chebulae (Terminalia chebula Retz.) or Terminalia chebula Retz. var. tomentella Kurt. (Terminalia chebula Retz.var.tomentella Kurt.).Its nature and flavor are bitter, sour, puckery, flat; Return lung, large intestine channel.The function that traditional medicine is recorded is that astringing intestine to stop diarrhea is astringed the lung, pathogenic fire reducing sore-throat relieving with curing mainly.For chronic diarrhea chronic dysentery, proctoptosis of having blood in stool, the deficiency of the lung is breathed with cough, and chronic cough is more than, pharyngalgia hoarseness.The fruit of modern chemical composition research display Fructus Chebulae is mainly containing tannin constituents, and major function is convergence and antidiarrheal, and clinical being mainly used in treats the diseases such as lobar pneumonia, bacillary dysentery pain, diphtheriaphor.
Semen Persicae, be the dry mature seed of rosaceous plant Fructus Persicae (Prunus persica (L.) Batsch) or Prunus davidiana (Prunus davidiana (Carr.) Franch.), function cures mainly and is the kidney invigorating, warming the lung, intestine moistening.For soreness of the waist and knees, impotence and seminal emission, deficiency and coldness is breathed heavily and is coughed, constipation.Modern medicine confirms that it possesses effects such as improving blood circulation, anticoagulation, antithrombus formation, antiinflammatory, antiallergic.
Semen Sesami Nigrum, be the dry mature seed of Pedaliaceae (Pedaliaceae) Sesamum plant sesame (Sesamum indicum L.), be conventional medicine and food raw materials, have invigorating the liver and kidney, benefiting essence-blood, intestine moistening is dry.For dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, effect of dryness of the intestine constipation.
Semen Juglandis, is the dry mature seed of juglandaceae plant Semen Juglandis (Juglans regia L.), is conventional medicine and food raw materials, has the kidney invigorating, warming the lung, intestine moistening.For soreness of the waist and knees, impotence and seminal emission, deficiency and coldness is breathed heavily and is coughed, effect of constipation.
Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae (Salvia miltiorrhiza Bge.).Traditional medicine thinks that Radix Salviae Miltiorrhizae function is stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, and clear away heart-fire relieving restlessness, and modern medicine confirms that it has protection cardiovascular system, blood fat reducing, anticoagulation, affects immune system, antiinflammatory and antianaphylactic effect.
Semen Cassiae is the dry mature seed of leguminous plant Semen Cassiae (Cassia obtusifolia L.) or little Semen Cassiae (Cassia tora L.).Traditional medicine thinks that it has clearing away heat to improve acuity of vision, effect of loosening bowel to relieve constipation.Modern medicine confirms that it has antibacterial, blood pressure lowering, antiplatelet aggregation, blood fat reducing, protects the liver, rushes down inferior effect.
Lignum Aquilariae Resinatum is Isolated From Thymelaeaceae Species Lignum Aquilariae Resinatum (Aquilaria sinensis (Lour.) Gilg) timber containing resin.Traditional medicine think its promoting the circulation of QI to relieve pain, warming middle-JIAO to arrest vomiting, helping inspiration to relieve asthma, modern medicine confirm its to digestive system and CNS inhibition all powerful.
The present invention also provides above-mentioned Tibetan medicinal composition preparing the application in phalacrosis prevention and hair generation product.Phalacrosis prevention and hair generation product mainly refers to the toiletries product or medicine with described effect, and product is liquid preparation for external application, as liniment, spray etc.This product be Tibetan medicinal composition of the present invention or its extracting solution directly as phalacrosis prevention and hair generation product, or with the phalacrosis prevention and hair generation product that this Tibetan medicinal composition or its extracting solution are effectiveness composition.
The present composition commonly uses Tibetan medicine material based on Tibetan, through for a long time, clinical trial widely screening, confirm to be made up of the Tibetan medicine of obvious phalacrosis prevention and hair generation effect.Fructus Phyllanthi in composition component, Fructus Terminaliae Billericae, Fructus Chebulae, practising and claim " Tibetan medicine Fructus Phyllanthi ", is Tibetan medicine's common drug." Tibetan medicine Fructus Phyllanthi " three medicines are used in conjunction, and be usually used in the treatment calentura initial stage and pathogenic heat (or heat in blood) and dragon are mingled with the phase, impel calentura molding at Tibetanmedicine; Another when blood-letting is treated, have the effect impelling bad blood to be separated with body blood with Fructus Phyllanthi soup, core or the important ingredient of Chang Zuowei Tibetan medicine prescription are widely used.Modern medical analysis shows " Tibetan medicine Fructus Phyllanthi " Fructus Chebulae, Fructus Terminaliae Billericae, Fructus Phyllanthi all contain abundant boots matter class, three mushrooms compositions, and chemical composition has stronger antioxidation.No matter be traditional medicine or modern medicine, the research and apply of " Tibetan medicine Fructus Phyllanthi " all mainly concentrated on to lifting and the health care of human body integral function.The present invention then utilizes, and " Tibetan medicine Fructus Phyllanthi " provides anti-oxidation efficacy, increases circulation and replys elasticity of skin, slow down alopecia and thin thickening, basic in this, as Tibetan medicinal composition phalacrosis prevention and hair generation effect.On " Tibetan medicine Fructus Phyllanthi " basis, according to Tibetan medicine and pharmacology clinical practice for many years, selected there is blood circulation promoting and blood stasis dispelling, improve microcirculation, the Semen Persicae of the pharmacologically active such as antibacterial, antiinflammatory, Semen Sesami Nigrum, Semen Juglandis, Radix Salviae Miltiorrhizae, Semen Cassiae, Lignum Aquilariae Resinatum composition of prescription.Proved by human clinical trial, Tibetan medicinal composition of the present invention all has the effect of anticreep growth to the hair loss patient of multiple age composition, and especially to seborrheic alopecia, alopecia areata clinical efficacy significantly, total effective rate reaches 94.4% and 96.7% respectively., prove through animal experiment, this Tibetan medicinal composition meets Safety and toxicology requirement meanwhile, without obviously bad should.
Compared with prior art, the invention has the beneficial effects as follows: the medical material that in (1) this Tibetan medicinal composition employing Tibetan medicine and pharmacology, tradition is common, conventional traditionally Tibetan medicine concocting method is prepared from, and is that the former medicine of medical material or preparation method are all safe and reliable; (2) Tibetan medicinal composition is applied to that phalacrosis prevention and hair generation is evident in efficacy, short treating period, has no side effect; (3) simple with this Tibetan medicinal composition phalacrosis prevention and hair generation production economical that is effectiveness composition, preparation method.
Detailed description of the invention
Below in conjunction with embodiment, technical scheme of the present invention is described further.
Test example one
Safety and toxicology is tested.Using Tibetan medicinal composition extract of the present invention as test specimen, carry out irritation test.
Prepared by test specimen:
Get Fructus Phyllanthi 3.16kg, Fructus Terminaliae Billericae 1.58kg, Fructus Chebulae 1.05kg, Semen Persicae 1.05kg, Semen Sesami Nigrum 1.05kg, Semen Juglandis 0.53kg, Radix Salviae Miltiorrhizae 0.53kg, Semen Cassiae 0.53kg, Lignum Aquilariae Resinatum 0.53kg, add 100L50% ethanol, soak at room temperature 20d, get supernatant, filter, sterilizing, fill, to obtain final product.
Test method:
Cleaning grade Japan large ear rabbit, body weight 2.2kg ~ 2.6kg, 8, male and female half and half, during experiment, single cage is raised.Before experiment, back part of animal spinal column both sides are cut by hair by 24h shaver, and unhairing scope is respectively 3cm × 3cm, application area 2.5cm × 2.5cm.
Getting test specimen 0.5ml is applied on the left of animal on skin, and blank solvent is smeared in contrast in right side, smears 1 every day, smears 14d continuously.From 2d, smear front cropping at every turn, and know residue test sample by warm water, observed result after 1h.Mark according to table 1 standards of grading, calculate animal average integral every day every, judge skin irritation intensity according to table 2.
Table 1 skin wound repair is marked
Table 2 skin irritation strength grading
Result of the test:
Smear 14d continuously, period each animal smear test specimen and blank solvent both sides skin wound repair scoring be all less than 0.5, belong to nonirritant.Meanwhile, the unusual condition that other systemic toxicity profiles such as behavioral activity, the mental status, breathing appear in animal is not observed.
Test example two
Safety and toxicology test and effect test.Using the extract of Tibetan medicinal composition of the present invention as test specimen, carry out normal individual trial test.
Clinical data:
Hair loss patient 66 example, wherein seborrheic alopecia 36 example (male 25 example, women 11 example), alopecia areata 30 example (being all male); 26 ~ 58 years old age, 39.4 ± 7.1 years old mean age, the course of disease 12 days ~ 13 years.All patients are not all in the mood for, Liver and kidney function abnormal and other serious diseases, and without allergic constitution or irritated to this medicine.
Therapeutic Method:
The test specimen got prepared by this test example one is appropriate, and smear head hair loss area, and massage 3min ~ 5min, 2 times on the 1st, January was 1 course for the treatment of, continuous 3 courses for the treatment of.Observe natural on-off cycles of hair growth situation before and after using, local irritation and the impact on routine blood test, routine urinalysis and the just conventional and heart, Liver and kidney function.
Criterion of therapeutical effect:
Criterion of therapeutical effect is as shown in table 3.
Table 3 criterion of therapeutical effect
Clinical therapeutic efficacy:
After solution of the present invention uses 3 months, seborrheic alopecia total effective rate is 94.4%, and the total effective rate of alopecia areata is 98.7%.Concrete outcome is in table 4.
Table 4 the present invention is to the clinical therapeutic efficacy of seborrheic alopecia, alopecia areata
Untoward reaction: observe case and all do not occur skin of head zest, comprise the symptom such as erythema, edema; Meanwhile, other general malaise diseases are also had no; The lab testing heart, liver, kidney merit and three large routines are all in normal range.
Brief summary: Tibetan medicinal composition of the present invention has significant clinical efficacy to seborrheic alopecia, alopecia areata.Have no obvious untoward reaction simultaneously.
Embodiment one
Prepare Tibetan medicinal composition preparation.
Former medicine component: Fructus Phyllanthi 30 ~ 90 parts, Fructus Terminaliae Billericae 15 ~ 45 parts, Fructus Chebulae 10 ~ 30 parts, 10 ~ 30 parts, Semen Persicae, Semen Sesami Nigrum 10 ~ 30 parts, Semen Juglandis 5 ~ 15 parts, Radix Salviae Miltiorrhizae 5 ~ 15 parts, Semen Cassiae 5 ~ 15 parts, Lignum Aquilariae Resinatum 5 ~ 15 parts.
Preparation method: after getting clean system former medicine traditionally Tibetan medicine material processing method be processed as coarse powder, coarse powder adds 30% ~ 70% ethanol water, alcoholic solution ratio for add alcoholic solution 5L ~ 15L in medicine original powder 1kg, soak 10d ~ 30d, get supernatant, filter, sterilizing, obtains Tibetan medicinal composition preparation.
Embodiment two
Prepare Tibetan medicinal composition preparation, itself and embodiment one something in common no longer repeat, the concentration of ethanol water when its difference is coarse powder immersion treatment.
Ethanol water (see table 5) is added in former medicine coarse powder.
Ethanol water concentration in Tibetan medicinal composition preparation prepared by table 5
Embodiment three
Prepare Tibetan medicinal composition preparation, itself and embodiment two something in common no longer repeat, and its difference is former medicine coarse powder immersion treatment condition.
In former medicine coarse powder, add ethanol water, addition is add alcoholic solution 10L in every medicine original powder 1kg, soaks 20d, gets supernatant, and filter, sterilizing, obtains Tibetan medicinal composition preparation.
Embodiment four
Prepare Tibetan medicinal composition preparation, itself and embodiment one or two or three something in common no longer repeat, and its difference is former medicine component.
Former medicine component ratio is as shown in table 6.
Table 6 prepares Tibetan medicinal composition preparation Central Plains medicine component and ratio (unit: part)
Claims (10)
1. for a Tibetan medicinal composition for phalacrosis prevention and hair generation, it is characterized in that: component is Fructus Phyllanthi 30 ~ 90 parts by weight, Fructus Terminaliae Billericae 15 ~ 45 parts, Fructus Chebulae 10 ~ 30 parts, 10 ~ 30 parts, Semen Persicae, Semen Sesami Nigrum 10 ~ 30 parts, Semen Juglandis 5 ~ 15 parts, Radix Salviae Miltiorrhizae 5 ~ 15 parts, Semen Cassiae 5 ~ 15 parts, Lignum Aquilariae Resinatum 5 ~ 15 parts.
2. Tibetan medicinal composition according to claim 1, is characterized in that: Fructus Phyllanthi 45 ~ 75 parts, Fructus Terminaliae Billericae 20 ~ 40 parts, Fructus Chebulae 15 ~ 25 parts, 15 ~ 25 parts, Semen Persicae, Semen Sesami Nigrum 15 ~ 25 parts, Semen Juglandis 8 ~ 12 parts, Radix Salviae Miltiorrhizae 8 ~ 12 parts, Semen Cassiae 8 ~ 12 parts, Lignum Aquilariae Resinatum 8 ~ 12 parts.
3. Tibetan medicinal composition according to claim 1, is characterized in that: Fructus Phyllanthi 60 parts, Fructus Terminaliae Billericae 30 parts, Fructus Chebulae 20 parts, 20 parts, Semen Persicae, Semen Sesami Nigrum 20 parts, Semen Juglandis 10 parts, Radix Salviae Miltiorrhizae 10 parts, Semen Cassiae 10 parts, Lignum Aquilariae Resinatum 10 parts.
4. the arbitrary described Tibetan medicinal composition of claims 1 to 3 is preparing the application in phalacrosis prevention and hair generation product.
5. the preparation method of the arbitrary described Tibetan medicinal composition for phalacrosis prevention and hair generation of claims 1 to 3, it is characterized in that: prepare the former medicine of clean system according to component proportion, by former for each component medicine traditionally Tibetan medicine material processing method make former medicine coarse powder, former medicine coarse powder adds 30% ~ 70% ethanol water, and alcoholic solution ratio, for add ethanol water 5L ~ 15L in medicine original powder 1kg, soaks 10d ~ 30d, get supernatant, filter, sterilizing, obtains Tibetan medicinal composition preparation.
6. method according to claim 5, is characterized in that: add 50% ethanol water in described former medicine coarse powder, ethanol water ratio for add ethanol water 10L in medicine original powder 1kg, soak 20d, get supernatant, filter, sterilizing, obtains Tibetan medicinal composition preparation.
7. with the phalacrosis prevention and hair generation product that the arbitrary described Tibetan medicinal composition of claims 1 to 3 or its extracting solution are effective ingredient.
8. product according to claim 7, is characterized in that: be for seborrheic alopecia phalacrosis prevention and hair generation product or/and for the phalacrosis prevention and hair generation product of alopecia areata.
9. the product according to claim 7 or 8, is characterized in that: be liquid preparation for external application.
10. product according to claim 9, is characterized in that: described Tibetan medicinal composition extracting solution is alcohol extract.
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| CN107485707A (en) * | 2017-08-03 | 2017-12-19 | 文成当智 | A kind of Tibetan medicinal composition and its application |
| CN110101776A (en) * | 2019-06-25 | 2019-08-09 | 西藏圣雪生物科技有限公司 | A kind of Tibetan medicinal composition of hair-growing and anti-hair loss and preparation method thereof |
| KR102462458B1 (en) * | 2019-10-31 | 2022-11-02 | 주식회사 큐롬바이오사이언스 | Composition for preventing or treating of benign prostatic hyperplasia or alopecia comprising extracts of Salvia miltiorrhiza Bunge as an effective ingredient |
| CN114903820A (en) * | 2021-02-10 | 2022-08-16 | 伽蓝（集团）股份有限公司 | Composition containing myrobalan fruit extract and preparation method and application thereof |
| CN113197998A (en) * | 2021-06-09 | 2021-08-03 | 青海香斯尔藏药研发有限公司 | Tibetan medicine composition for growing, nourishing and preventing hair loss and preparation method thereof |
| CN115414424B (en) * | 2022-04-15 | 2024-03-22 | 西藏自治区藏医院(西藏自治区藏医药研究院) | Phyllanthus emblica spray for preventing and treating alopecia and promoting hair growth and preparation method thereof |
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| CN1899554A (en) * | 2006-07-04 | 2007-01-24 | 洛嘎 | Tibetan tonic for improving immunity and its preparing method |
| CN102258437A (en) * | 2010-05-28 | 2011-11-30 | 旦巴颜排 | Hair nourishing liquid |
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| CN1899554A (en) * | 2006-07-04 | 2007-01-24 | 洛嘎 | Tibetan tonic for improving immunity and its preparing method |
| CN102258437A (en) * | 2010-05-28 | 2011-11-30 | 旦巴颜排 | Hair nourishing liquid |
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