KR20160118417A - Manufacturing Method and Composion for Viper Venom Liquid Mixture - Google Patents

Abstract

The present invention relates to a composition for alleviating or treating atopic dermatitis using viper venom liquid, Morus alba roots, Houttuyniae Herba, Hedyotidis Diffusae Herba, Ulmi Cortex, Acer Tegmentosum Maxim, Sanguisorba officinalis L., and Xanthii Fructus. The composition of the present invention having natural medicinal herbs as a raw material has reduced side effects, and has excellent effects in treating various dry and oily skin inflammations or the like.

Description

Technical Field [0001] The present invention relates to a raw material composition for atopic cosmetics and ointment,

The present invention relates to a raw material composition for atopic cosmetic and ointment of a salmon snake venom liquid mixture and a preparation method thereof, and relates to a composition for treating atopy as a snake venom liquor. More specifically, the present invention relates to a raw material for a liquid snake skin cosmetic and ointment, and a method for manufacturing a snake skin without toxicity of a snake snake for acne and atopy treatment.

Methods for ameliorating or treating atopic skin diseases include, but are not limited to, methods for improving skin dryness symptoms, methods of using immunomodulators to inhibit the production of 1gE, methods of using antibacterial and / And a method of combining two or more of them is also known.

Korean Patent Publication No. 10-0539965 to which a new pseudoceramide has been applied for reducing skin dryness is disclosed in Japanese Patent Application Laid-open No. 10-0539965, which is based on a novel pseudoceramide. Korean Patent Registration No. 10-0539965 discloses a composition for external application which is characterized by containing fructose 1,6-diphosphate or a derivative thereof to improve dryness of the skin. Korean Patent Laid- ≪ / RTI >

As an immunomodulator, a therapeutic drug for the use of an interferon B as an active ingredient for an atopic disease is disclosed in Korean Patent Publication No. 10-02783, which is disclosed in Korean Patent Laid-Open Publication No. 10-009861, A cosmetic composition is disclosed in Korean Patent Publication No. 2004-0029850.

A cosmetic composition for improving atopic skin comprising an oriental leaf or stem extract having antimicrobial activity against Staphylococcus aureus which aggravates symptoms of atopy as an active ingredient is disclosed in Korean Patent Publication No. 2006-0054807.

Korean Patent Publication No. 10-0497665 discloses a method for treating or reducing symptoms of various skin diseases such as atopic dermatitis when non-polar saponins are produced by heating ginseng plants at 110 to 180 ° C for 0.5 to 20 hours to form non-polar saponins, Soap containing titanium oxide, polyethylene glycol, chitosan, humectant, glycerin, mugwort powder, pine needle powder, apricot seed powder, yulmu powder, ginseng powder, seaweed powder, elvan powder, licorice powder, mulberry powder, .

In addition, many techniques have been introduced for mixing various components to have a composite function.

A cosmetic composition containing ceramide, aloe vera, green tea extract and gold extract as an active ingredient, which contains an antibacterial component and an anti-inflammatory component and which has a moisturizing action, is disclosed in Korean Patent Publication No. 2002-0076375.

A cosmetic composition characterized by containing a surfactant, a higher alcohol, a moisturizing ingredient, a anti-inflammatory ingredient and an itching-inhibiting ingredient is disclosed in Korean Patent Publication No. 2002-0046329.

The herbal composition for treating atopic diseases, which includes herb, oriental ginseng, oriental ginseng, oriental ginseng, camellia, creation, mahwang, ganghwam, keel, windshield, sezin, Which is characterized by being used as an oral therapeutic agent.

A health food composition for the prevention and treatment of allergic rhinitis and cold comprising active ingredients of yugunpyu, dandruff, licorice, omija, waiin, mugwort, hwanggi, mangmundong, Is known from Patent Publication No. 10-0566542.

A therapeutic agent for oral allergic rhinitis and atopic dermatitis containing as a main component the ingredients of Uiin, Mwaiwoppyu, Hwasungcho, Gyungyoung, Jiwanghwang, and Geumgwha is known from Korean Patent Publication No. 2002-0089275.

The ointment-type composition for external use for atopic dermatitis, similar to the present invention, is prepared by mixing lignocellulosic, licorice, and safflower as main components with lard, which is known in Korean Patent Publication No. 10-2004-0011584. Skin moisturizing and anti-inflammatory compositions containing lower alcohol extracts of cloves, sculptors, interlining and tea preparations are disclosed in Korean Patent Publication No. 10-2008-0006837.

Methods for treating or ameliorating atopic dermatitis described above are intended to alleviate or ameliorate one or more of the symptoms such as itching or antiinflammation. Serious adverse effects such as complex infection may occur. .

Also, those containing various herbal medicines are mainly oral medicines or health supplements, which may be beneficial in relieving atopic dermatitis, but other side effects may occur.

As in the present invention, when various natural herbal medicine materials are used, the methods for improving side effects may be different from each other.

In addition, antihistamines, steroids, bronchodilators and the like are used as the popular therapy, but this is a method of improving the symptoms only. Steroids require long-term use, and overuse can cause side effects such as rash, redness, acne, edema, and hip problems.

Accordingly, the present invention has been developed in order to solve the above-mentioned problems, and it has been developed to solve the above problems by using snake venom without toxicity from snakeskin snake liquor to solve the itching improvement of skin, anti-inflammatory action, antibacterial action, And to provide a composition for alleviating or curing atopic dermatitis.

The composition according to the present invention is useful as a composition for improving the skin itching, anti-inflammation, antimicrobial and moisturizing action, such as a salmonella snake venom, a mulberry root, a whitetoptera, a white pheasant, a milky white, And an extract thereof.

The composition of the present invention comprises 10 g of salmon snake venom, 10 to 60 parts by weight of mulberry root, 5 to 20 parts by weight of horsetail, 5 to 20 parts by weight of bloom, 5 to 30 parts by weight of milky white, 3 to 15 parts by weight of mandarin, , 1 to 10 parts by weight of oat, and 1 to 10 parts by weight of sorbitan as an active ingredient.

The composition components of the present invention are specifically exemplified by the antimicrobial anti-inflammatory effects, such as Salmonella snake venom, mulberry root, It is composed of milky blood which is effective for the skin diseases such as the oily (beak) and the boil which perform the hemostatic function.

The above-mentioned one kind of snake venom snake venom and seven kinds of herbal medicine raw materials may be used at once or in separate pairs, mixed with various herbal extracts extracted with water, a lower alcohol, a solvent such as methyl chloride, methylene chloride or the like, The product extracted with an organic solvent may be lyophilized and dissolved in water to be applied to the affected area for external use.

The lyophilized powders may also be mixed at various ratios and mixed with bath water during bathing. The extract (liquid) or extract may be dissolved in a mixture of alcohol and water, or the alcohol may be mixed with the water extract to prepare tincture and sprayed or directly applied. It may also be prepared by using cream, gel, ointment, lotion, or the like, which contains the extract (liquid) or the lyophilized powder of the extract as an active ingredient.

Accordingly, the composition of the present invention is effective as an effective ingredient of a salmonid snake venom liquid, a mulberry root extract, a mulberry root extract, a white paprika extract, a milky white extract, a Prunus mume extract, an oat extract, It exhibits an excellent healing effect even in dry and oily dermatitis such as various acne, burns, burgers, etc., and can be usefully used for skin disease improvement and treatment.

Hereinafter, embodiments of the present invention will be described in detail.

The production methods and natural ingredients of the snake snake venom are well known as the following ingredients and actions, and some of the ingredients have been mainly used in private by themselves.

Snakes  Snakehead

Skin regeneration, antioxidant, anti-epileptic effects have atopy and acne healing effects, and you get 10 grams of snake venom from 180 to 200 snakes. Add 10 grams of salmon to 1 L of alkaline water in a jar, boil it at 100 C for 30 days and store in a cool place.

Mulberry roots

Use mulberry or other roots. Mulberry roots can also be used instead of mulberry root. The outer appearance of the alfalfa is composed of tubular sections with tubular, semi-tubular, band-shaped fragments or many exposed fibers. The main components of the alfalfa are morucinol, quanone, oxydihydroamorphin, and moruccin. The pharmacology of Alcoholic Extract of Alaska pollack is exercise gentle, breathing stimulation, sedation, blood pressure enhancement. The application of bovine alfalfa is mainly used as hypotensive, anti-inflammatory, diuretic and is used for nervous breakdown, insomnia, gray hair and diabetes.

Sophora

Horseshoe is used as the dried ground part of the flowering time of the seedling belonging to Saururus chinensis. In Japan, it is also called a dragon, and a dragon in the middle. The main components in the outpost are decanoyl acetaldehyde and oxidation products such as methyl ketone, laurin aldehyde and co-prinaldehyde. It contains aquaticin as a pigment of leaves. The pharmacological effect is antibacterial, immunity enhancement, anti-inflammation, Iyo, and Jinhae. The application of Hwasungcho is used for cough, pneumonia, acute bronchitis, enteritis, urinary tract infections, boils caused by lung abscess. In addition, it is also used when there is a lot of heat and urine. It has long been used in the private sector as a remedy for acne and atopy, and some patients may develop toxic side effects.

Bleacher

Baekhwaseulsaekchon refers to Baeknwulpu of the madder and it uses the outpost of it well dried. Madagascar and plants are known to contain several types of alkaloids. It has pharmacological actions to inhibit acute lymphocytic, granular, and mononuclear leukemic tumors, as well as antibacterial and anti-inflammatory effects. Applications include seawater, tonsillitis, sore throat, appendicitis, pelvic inflammation, jaundiced hepatitis, and dysentery due to waste heat, and also have a detoxifying effect on boils and snakeheads.

Milky blood

Milk-blooming is the bark of the elm of Elm with the Krk layer removed. Other names are Youngo, Yupi, and Yukinopi. It has been reported that pharmacological action is used as a cancer treatment agent in the private sector. Milky white blood is used for urine discomfort, urination pain, hematuria, and it is also used for underpants or external use for boils, males, omnis, and ringworms.

Prick

Bee is a deciduous broad-leaved arboreous tree with a maple tree. It grows mainly in the valleys and valleys of highlands over 600 meters above sea level. Leaves, branches, stems, and roots are all available, but stem is preferred. Its pharmacological effect is known to be effective for the treatment of liver cancer, liver cirrhosis, hepatitis, and leukemia. If you do not have a timber, you can use a timber instead.

Oylum

Oylum is a perennial herb that belongs to Rosaceae in the mountains and fields. It uses well dried outpastes including leaves and sprinkles. The roots of Oylus are also known as Jiyu. The crude oil contains about 17% of tannin and saponin. It has a hemostatic effect and is used for hematemesis, hemorrhage, hemorrhage, uterine hemorrhage, excessive menstrual flow, It is mainly used for fever, diarrhea, dysentery and skin name. Recently, it is used for burn and laceration by folk remedy. Vitamin C is contained in the leaf of Oylum.

Window

The cherry is used to say the fruit of a chrysanthemum, and dried well. Changchang contains about 39% of fatty oil, which is linoleic acid-based. It has fever, cold, headache, neuralgia, rhinosomalgia, limb pain paralysis, itching of skin, itching of the middle ear, etc. due to pharmacological action by essential oil and alkaloid, and has fever, sweating, admiral, blood sugar lowering, prevention of leukocyte reduction, Is used.

The embodiments given below are intended to embody the present invention, and the scope of the present invention is not limited by the embodiments in accordance with the gist of the present invention.

[Example]

Example 1

The first is to add 2.4 liters of salmon snake venom toxic to water 30 liters, 7 kg of mulberry root, and mildly burn for 24 hours or more until the water is about half (15 liters). Put 2 liters of water in 2 liters of water, 2kg of whitewater, 2kg of whitewater, 2.5kg of white paprika, 1.5kg of oak, 600g of oat, 600g of glutinous rice, and 600g of water. It is about 12 hours until the amount of water is reduced to about 20 liters by weak fire. The mixture of two extracts (35 liters) was cooled, sealed in a suitable size container (100 ml), stored in a refrigerator, and applied to the lesion of atopic patients.

Example 2

Put 5 liters of salmon snakes in water, 7 kg of mulberry roots, 2 kg of mulberry roots, 2 kg of white birch specimens, 2.5 kg of milky white pears, 1.5 kg of oak pine, 600 g of oillfruit and 600 g of sorghum and put them in a container for about 20 liters until the amount of water is reduced to about 30 liters It takes more than an hour. The extract (about 30 liters) was cooled, sealed in a suitable size container (100 ml), stored in a refrigerator, and applied to the affected part of the atopic patient.

Example 3

Ethanol (content 30%) was mixed one by one in the mixture of extract prepared in Example 1 and sealed in a 100 ml container and refrigerated.

The composition for treating atopy of the examples prepared above was tested on three groups of 20 patients aged 5 to 30 years who had severe atopic symptoms.

Patients in the three groups were approximately similar in age distribution. Therapeutic test methods were as follows: First, the composition was chilled before bedtime and used in spring, summer and autumn. In winter, it was soaked in boiling water and used slightly. The method of use was repeated 4 to 5 times to treat the affected area evenly with a cotton swab or cotton swab, and then repeatedly applied.

Prior to the direct treatment of skin of atopic patients, the residual amount of heavy metals in the extract was tested by the Korea Testing and Research Institute. Heavy metal test results according to Food Code (2009) The extracts of Examples 1 and 2 contained 0.0 mg / kg of lead, 0.0 mg / kg of mercury, 0.1 mg / kg of arsenic and 0.0 mg / kg of cadmium. According to the Korea Food and Drug Administration (KFDA) "Criteria and test methods for residual pollutants such as herbal medicines" (Korea Food and Drug Administration Notice No. 2009-104), vegetable herbs contain less than 5 mg / kg lead, arsenic 3 mg / kg, mercury less than 0.2 mg / kg And herbal extracts are prescribed to be less than 30 mg / kg of heavy metals. All of the herbal medicine raw materials used in the examples were either national or self-cultivated, so that the heavy metal content was judged to be small.

The results of the study showed that patients were cured about 2 weeks after treatment and needed treatment for 4 weeks or more. Examples 1 and 2 showed almost the same effect. About 70% (14) of the compositions of Example 1 were cured within about 2 weeks, 90% (18) were cured within 4 weeks, and 2 (10% And less than 10%.

Approximately 65% (13 patients) were cured within 2 weeks, 85% (17 patients) were cured within 4 weeks, and 3 patients (15% % And was cured in 7 weeks.

The composition of Example 3 was the most effective, and about 70% (14 patients) were cured within 2 weeks and 95% (19 patients) were cured within 3 weeks. And less than 10%.

In the case of the tincture using alcohol, it was found that the therapeutic effect is improved by dissolving the oil soluble ingredients such as fat, fatty acid and alkaloid in the affected part, and by disinfecting with alcohol.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is clearly understood that the same is by way of illustration and example only and is not to be taken in conjunction with the scope of the present invention. It will be understood by those skilled in the art that various changes may be made and equivalents may be resorted to without departing from the scope of the appended claims.

Claims (5)

A raw material composition of atopic cosmetic and ointment for a liquid mixture of salmonella snake containing an active ingredient of a salmonid snake liquor, a mulberry root extract, a mulberry root extract, a mulberry root extract, a mulberry root extract, a mulberry extract, a mulberry extract, a mandarin extract,
[Claim 3] The composition according to claim 1, which comprises 1 to 10 parts by weight of a salmon snake venom, 10 to 60 parts by weight of a mulberry root, 5 to 20 parts by weight of a mulberry root, 5 to 20 parts by weight of a white pheasant, 5 to 30 parts by weight of a milky lotus, To 15 parts by weight of an ointment, 1 to 10 parts by weight of an ointment, and 1 to 10 parts by weight of an extract prepared by using an extract as an active ingredient,
The composition according to claim 1 or 2, wherein the formulation of the composition is a tincture, cream, gel, ointment or lotion,
(1) The process of putting the juvenile snake vodka liquid and mulberry roots in water until the amount reaches half
(2) The process of hanging until the amount of water becomes 2/3 by putting in the water, the whitewater, white birch,
(3) a step of mixing the extract of step (1) and the extract of step (2)
For the production of atopic cosmetic and ointment raw material compositions of snake snake venom liquid mixture comprising
The method according to claim 4, wherein the extract mixture prepared in the step (3) is mixed with an equal amount of ethyl alcohol in an amount of 20% to 90% to prepare a tincture of Snake snake venom liquid mixture to prepare a raw material composition for atopic cosmetic and ointment Way.