KR101239879B1 - Cosmetic composition for mitigating skin troubles - Google Patents

Abstract

The present invention includes the extract of high concentrations of natural calcium, high calcium and high mineral components of water, gold, yellowish white, eoseongcho, three hundred vinegar, soybean mushroom, autonomous and licorice extract, and improve the damaged skin barrier and golden, yellowish white, etc. It is an object of the present invention to provide a cosmetic composition that can improve atopy or itching without side effects through synergistic effects of antibacterial, anti-inflammatory, anti-allergic, free radical scavenging and the like.
Cosmetic composition according to the present invention, based on the total weight, using a water containing a total content of more than 10,000mg per liter of calcium, including more than 3,000mg per liter of gold, golden, yellow white, eoseongcho, three hundred seconds, thirsty mushroom , Characterized by containing the extract extracted from the at least one substance selected from the group consisting of licorice and licorice as an active ingredient.

Description

Cosmetic composition for skin trouble improvement {COSMETIC COMPOSITION FOR MITIGATING SKIN TROUBLES}

The present invention relates to a cosmetic composition comprising a component that can improve skin troubles such as atopy or itching, and it is a natural material of high calcium and high mineral ingredients such as golden, yellow white, fish vinegar, triticale, thirsty mushrooms, autonomy and licorice. By including extracts extracted at high concentrations, synergistic effects of high minerals on damaged skin barriers and antimicrobial, anti-inflammatory, anti-allergic, and free radical scavenging effects included in gold, yellow and white, etc. B relates to a cosmetic composition that can improve the itch.

Atopic dermatitis is a chronic inflammatory skin disease that is repeated and worsened. It is also associated with itching, allergic rhinitis and asthma caused by the destruction of the skin barrier.

The cause of atopic dermatitis is not fully understood, but it may be due to an immune hypersensitivity reaction due to an increase in allergen-related immunoglobulin Ig E or a lack of T lymphocyte function. Ig E attaches to mast cells of mucous membranes or skin, and if its concentration is high, histamine is secreted from mast cells to cause inflammation. In most patients with atopic dermatitis, serum Ig E levels are elevated and the clinical severity of atopic dermatitis is found to be proportional. In this regard, it has been found to secrete cytokines such as IL-4, which induces Ig E production, IL-5, which promotes Ig E production, and IL-6, which amplifies Ig E production.

On the other hand, the oriental medicine is regarded as a cause of atopic dermatitis because 'the fever inside the body made poison'. The heat poison that was hiding deep inside the body comes up to the skin layer and causes various troubles. Therefore, atopic dermatitis will continue to recur unless heat poisoning is resolved. Especially during pregnancy, spicy and salty foods, excessive caffeine, alcohol, instant, oily foods, ingested a lot of waste, uterus is a lot of waste, or if the uterus is weak in the fetus is said to cause atopic dermatitis in the fetus. Not only does it cause skin abnormalities, but it also lowers the body's immunity and causes various complications. Therefore, it does not merely treat symptoms but claims to find the cause of atopic dermatitis. In other words, it is said to be able to prevent recurrence by releasing heat poison, which is the cause of atopic dermatitis, and improving the self-sustaining ability to fight allergies.

Among the causes of the development of atopic dermatitis, which have been variously discussed in recent years, an important system that is considered is an abnormal system of antioxidant system and the generation of excessive reactive free radicals. Originally, free radicals act as a defense mechanism to extinguish exogenous pathogens that have penetrated the body as part of the immune system, but the sensitivity is high in the body and skin of patients with atopic dermatitis. It is known to damage.

The cause of this immune hypersensitivity reaction and the excess of free radicals is not clear the underlying cause, but the function of the immune system due to internal and external stress caused by the influx of environmental hormones such as dioxins due to environmental pollution, mainly due to genetic pollution. It is known to be caused by deterioration and destruction. In addition, damage to skin barriers associated with atopic dermatitis, secondary bacterial infections, increased susceptibility to drug side effects, and decreased resistance to infections such as fungi and viruses are also present.

In order to treat such atopic dermatitis, it is considered to remove allergens or improve the immune system. Since it is difficult to remove allergens, mainly treatment related to immunity and drug treatment to lower histamine secretion from mast cells Receiving is a common way.

Currently used treatments include topical corticosteroids and immunosuppressive agents to alleviate various symptoms caused by atopic dermatitis or to apply moisturizers to prevent skin drying in atopic dermatitis and to treat the accompanying inflammation. The same steroid is used. However, since long-term use of these steroids causes various skin side effects such as steroidal acne, skin atrophy and capillary dilatation, it is necessary to develop natural materials that exhibit anti-inflammatory effects without showing such side effects.

In addition, antihistamines are used as a temporary measure to reduce the itching symptoms by preventing histamine from being released from mast cells, and may have side effects such as insomnia, anxiety, and loss of appetite when taken for a long time.

Atopic dermatitis, on the other hand, is a more frightening disease of secondary bacterial infections caused by itching and scratching, and atopic dermatitis is accompanied by bacterial infection as a result of long-term scratching and drying. For example, more than 90% of patients with atopy are infected with Staphylococcus aureus, which can be caused by scratching because the patient can't stand itching, but recent reports suggest that the toxins in these bacteria stimulate the body's immune system to cause allergies. It is said to worsen atopy by letting out substances. In other words, the bacteria themselves act as allergens. Therefore, the use of appropriate antibiotics is essential for the treatment of atopy.

Other medications include nonsteroidal ointments, which are moisturizers. In addition, sedatives or nerve stabilizers are used to soothe the skin, and at night, an ointment is applied to moisturize the skin and wrap the area with a wrap.

However, these conventional treatments and treatments do not fundamentally improve atopic symptoms and have many disadvantages.

The present invention is to improve the problems of the above-mentioned conventional skin treatments such as atopic dermatitis, extracts of golden, yellowish white, eochocho, triticale, thirsty mushrooms, licorice and / or licorice with water of high mineral ingredient containing a large amount of calcium It is used as an active ingredient in cosmetics to improve the damaged skin barrier on the troubled skin through the high calcium, high minerals contained in the extract and at the same time antibacterial, antifungal, free radical scavenging, anti-inflammatory and moisturizing effect By treating and preventing the secondary infection by the microorganism through, there is a problem to solve the problem to provide a cosmetic composition excellent in improving the skin troubles such as atopic itch without side effects.

As a means for solving the above problems, the present invention is a water containing a total content of more than 10,000mg per liter of calcium, including more than 3,000mg of calcium per liter, gold, yellow white, eoseongcho, 300 seconds, thirsty mushrooms, licorice and licorice It provides a cosmetic composition for improving atopic skin, comprising as an active ingredient an extract extracted from one or more substances selected from the group consisting of.

In the present invention, the "mineral component" means an inorganic material that does not contain carbon, oxygen, and hydrogen constituting a living body.

In addition, in the present invention, the term "extract" refers to 2 liters of water containing a total content of minerals of 3,000 mg or more of calcium, including 10,000 mg or more, of gold, yellow white, fish leaf, triticale, thirsty mushroom, And it is put so that the sum of one or more substances selected from the group consisting of licorice is 1kg, and heated to 50 ~ 100 ℃ extracted until the water is 1 liter, it means to remove the solids through the filter medium.

Since the cosmetic composition according to the present invention contains more than 10,000 mg of mineral component per liter and at the same time contains more than 3,000 mg of calcium ions in the mineral component, a sudden change in Calcium Gradient is applied when applied to damaged skin. By causing homeostatic responsiveness in the skin, thereby acting to quickly restore the function of the skin barrier. That is, the composition according to the present invention is characterized in that the skin itself can be recovered, not a temporary effect due to skin moisturizing by the extract, and more preferably, the calcium contained in the water is 5,000 mg or more per liter. . In addition, another feature of the present invention is to put a substance such as gold in the water containing the high minerals to extract the material contained in the golden, etc., which is warm, which is antibacterial, antifungal, free-racial Through the effects of scavenging and anti-inflammatory, it plays a role of preventing or treating secondary infection by microorganisms on the improved skin barrier. In addition, in the case of extracting gold and the like with water containing high minerals, the extract is easier to prepare than the mixture of water containing the high minerals and gold and the like, and the high mineral content of water is contained in the gold and the like. The extracted material can be more easily extracted, making it more suitable for skin trouble improvement.

In addition, in the composition according to the present invention, the extract is characterized in that it contains 1 to 70% based on the total weight of the cosmetic. The higher the concentration of the extract, the better the improvement of skin troubles, but when it exceeds 70%, the improvement of the effect is saturated and meaningless, and in the case of anhydrous formulations, it is difficult to add more than several%, but at least 1% or more. This is because the skin trouble can be improved.

In addition, in the composition according to the present invention, the water may be added with a mineral component in pure water, but more preferable is mineral water containing natural minerals.

In addition, in the composition according to the present invention, the golden extract: 0.1 ~ 20.0%, the baekbaek extract: 0.1 ~ 20.0%, the Echochocho extract: 0.1 ~ 20.0%, the triticale extract: 0.1 ~ 20.0%, the neck mushroom extract : 0.1 to 30.0%, the licorice extract: 0.1 to 20.0%, the licorice extract: 0.1 to 40.0% is preferred.

In addition, in the present invention, the golden (Scutellaria baicalensis G EORGI) is dried by peeling the roots of the golden perennial herb belonging to Lamiaceae (Labiatae), there is an effect of dehumidification fever, hemostasis, anxious (安胎) It is a herbal medicine that has been used in the treatment of hypertension and epidemic meningitis due to prescriptions such as Hwangnyeonhaedoktang, Yongdamsagantang, and Whangwangcheongsimhwan. . Ingredients included in gold include baicalein, baicalin, wogonin, wogonin 7-O-glucuronide, oroxylin A ), 30 kinds of flavones such as oroxylin AO-glucuronide, phenylethanoid, amino acid, sterol and essential oil oil, etc., and contains several kinds of flavonoids such as baicalin, baicalein, wogonin, and oroxylin A. These ingredients are effective for antibacterial, anti-inflammatory, anti-allergic and free radical removal.

The Phellodendri Cortex is a stem bark peeled from the bark of a yellow wall (pedar) or other related plants, berberine, palmatine, guanidine, jatrorrhizine, Alkaloids such as phyellodendrine, candicine, and menisperine, high-tingling substances such as obakunone and obakulactone, and steroidal substances It is effective against antibacterial, anti-inflammatory and antioxidant.

The fish herb (Houttuynia cordata Thunb, weak mole) is a perennial herb belonging to more than three hundred, and contains substances such as decanoyl acetaldehyde, isoquerchirun, querchitrrun, and is effective against antibacterial and antiviral.

The three hundred vinegar (Saururus chinensis) is a dried plant, the main component of the starch is methyl-n-nonyl ketone (methyln-nonyl ketone), the stem contains a hydrolyzable tannin, the leaves quercetin (quercetin), isoque It contains isocerrcetrin, abiculin, ahyperin, rutin and hydrolyzable tannin, and is effective in antibacterial and anti-inflammatory.

Radix Lithospermi is a root part of perennial herb with Lithospermum erythrorhizon, and contains components such as polysaccharide Lithosperman, together with Shikonin, Acetylshikonin, and the like. Shikonin-related compounds are particularly effective against antibacterial, anti-inflammatory and antiviral agents, as well as for skin regeneration.

The licorice (Glycyrrhizae Radix) is a perennial herb belonging to the legume (Leguminosae), the root and the gourd of the European licorice (Glycyrrhiza glabraL.), Manju licorice (Glycyrrhiza uralensis F.) or other congenital plants (그대로 出 莖) as it is or As the outer skin is removed, it contains a lot of triterpenoids and glycyrrhizic acid, and is effective in anti-inflammatory, anti-allergic and antibacterial effects.

When the extract of each of the substances is added less than 0.10%, it is difficult to obtain the effects of sufficient action and function of each substance, and when administered above the above range, discoloration, discoloration, etc. easily occur, making it difficult to formulate cosmetics. In addition, since the improvement effect is not better, it is preferred to be added in the above range.

In addition, the cosmetic composition for the formulation, arachidyl alcohol: 0.5 to 1.0% by weight, behenyl alcohol: 0.5 to 1.0% by weight, arachidyl glucoside: 0.5 to 1.0% by weight, cetearyl alcohol: 1.0 to 2.0% by weight , Cetearyl oleate: 0.5-1.0 wt%, sorbitan oleate: 0.5-1.0 wt%, shea butter: 1.0-2.0 wt%, caprylic capric triglyceride: 5.0-10.0 wt%, calendul La flower oil: 1.5-3.0% by weight, grape seed oil: 1.0-2.0% by weight, jojoba seed oil: 2.0-4.0% by weight, olive oil: 1.0-2.0% by weight, dimethicone: 0.5-1.0% by weight, sodium hyaluronate : 2.0-4.0 wt%, Beta-glucan: 2.0-4.0 wt%, Panthenol: 0.1-0.5 wt%, Willow Extract: 0.1-0.5 wt%, Golden Extract / Moran Root Extract: 1.0-2.0 wt%, Xanthan Gum : 0.1 to 0.5% by weight, glycerin: 5.0 to 10.0% by weight, cetearyl glucoside: 1.0 to 2.0% by weight, glycosyl trehalose: 2.0 to 4.0% by weight, citric acid: 0.01 to 0.2% by weight, and purified water.

The cosmetic composition for improving skin troubles according to the present invention is a synergistic effect of antimicrobial, antifungal, free radical scavenging, anti-inflammatory and moisturizing effects of ingredients contained in gold and the like extracted with water of high mineral ingredient along with improvement of skin condition of high mineral ingredient. Through, it is possible to improve the skin troubles such as atopy or itching without side effects.

Figure 1a is a photograph showing the skin condition before applying the cosmetic according to an embodiment of the present invention.
Figure 1b is a photograph showing the skin condition after applying the cosmetic according to an embodiment of the present invention.

The singular forms used to describe the embodiments of the present invention are intended to include the plural forms as well, unless the phrases clearly indicate the opposite. And “includes” embodies a particular property, region, integer, step, operation, element, and / or component, and the presence or addition of another particular property, region, integer, step, operation, element, component, and / or group. It is not excluded.

Unless defined otherwise, all terms including technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. In addition, the commonly used terms defined in advance are ideal unless they are additionally interpreted and defined as having a meaning consistent with the related technical literature and the presently disclosed contents. It is not interpreted in a very official sense.

Hereinafter, with reference to the accompanying drawings will be described in detail a manufacturing method and a practical application of the cosmetic composition according to an embodiment of the present invention, the present invention is not limited to the following embodiments. Therefore, it will be apparent to those skilled in the art that the present invention may be variously modified without departing from the technical spirit of the present invention.

Preparation of High Mineral Mineral Water Extract

As the water used in the embodiment of the present invention, high mineral mineral water containing a large amount of calcium and other minerals was used, and the analysis results of the used mineral water are shown in Table 1 below.

Component Analysis Results of Mineral Waters Used in Examples of the Present Invention ingredient unit content ingredient unit content Na mg / L 2330 Zr mg / L 1.99 Cl ^- mg / L 13200 Se mg / L 0.03 Ca mg / L 5690 B mg / L 0.40 K mg / L 75.1 Mn mg / L 112 Mg mg / L 509 Co mg / L 9.42 Li mg / L 2.27 Ni mg / L 250 Sr mg / L 109 Ba mg / L 193 SO4 ^{2 -} mg / L 586 Cu mg / L 9.22 SiO ₂ mg / L 0.26 V mg / L 78.8 F ^- mg / L 1.30 Cr mg / L 53.2 Br ^- mg / L 49.3 Ag mg / L 1.41 Fe mg / L 0.04 - - -

As confirmed in Table 1, in the case of mineral water used in the embodiment of the present invention, the content of calcium is very high, 5690 mg per liter. The high mineral mineral water thus obtained was subjected to the process of filtering the foreign matter twice by reverse osmosis, and concentrated minerals to produce high mineral mineral water having a mineral content of 10000 mg or more per liter.

2 liters of high mineral mineral water prepared in this way was added 100 g of golden, 100 g of yellow white, 100 g of eoseongcho, 100 g of trichophyte, 200 g of soybean mushroom, 100 g of licorice and 300 g of licorice. Extraction was carried out for 10 liters by holding for 10 hours, cooled, and filtered through a 1 micron filter to remove solids, thereby producing extracts (hereinafter, referred to as 'high mineral mineral water extracts').

Manufacture of cosmetic cream

Using the high mineral mineral water prepared as described above to prepare a cosmetic cream having the components shown in Table 2.

Specifically, first, purified water, glycosyltrehalose, cetearyl glucoside, glycerin, and xanthan gum were added to a high mineral mineral water extract in a content as shown in Table 2 below, and dissolved at 80 ° C. to prepare a completely dispersed aqueous phase using a stirrer. .

Then, arachidyl alcohol, behenyl alcohol, arachidyl glucoside, cetearyl alcohol, cetearyl oleate, sorbitan oleate, shea butter, caprylic capric triglyceride, calendula flower oil, grape seed oil , Jojoba seed oil, olive oil, dimethicone was completely dissolved at 85 ℃ and then mixed with the aqueous phase and dispersed again using a stirrer. After cooling to room temperature, sodium hyaluronate (1%), beta-glucan, panthenol, willow extract, golden extract / moran root extract were added to prepare a cream.

Then, citric acid, which is a formulation formation, was added to adjust the pH of the composition to 5.5 to 6.5 to form a formulation.

In addition, in contrast to Examples 1 to 3 of the present invention, purified water was added instead of the high mineral mineral water extract, and the remaining components were prepared in the same manner as in Example 1.

Composition of the cream according to an embodiment of the present invention ingredient Example 1
(weight%) Example 2
(weight%) Example 3
(weight%) Comparative Example
(weight%) Arachidil Alcohol 0.6 0.6 0.6 0.6 Behenyl Alcohol 0.6 0.6 0.6 0.6 Arachidil Glucoside 0.6 0.6 0.6 0.6 Cetearyl Alcohol 2.0 2.0 2.0 2.0 Cetearyl olivate 0.5 0.5 0.5 0.5 Sorbitan olivate 0.5 0.5 0.5 0.5 Sheer butter 2.0 2.0 2.0 2.0 Caprylic.Caprictriglycerides 7.0 7.0 7.0 7.0 Calendula Flower Oil 2.0 2.0 2.0 2.0 Grape seed oil 1.0 1.0 1.0 1.0 Jojoba Seed Oil 3.0 3.0 3.0 3.0 Olive oil 1.0 1.0 1.0 1.0 Dimethicone 0.7 0.7 0.7 0.7 Sodium Hyaluronate (1%) 3.0 3.0 3.0 3.0 Beta-glucan 3.0 3.0 3.0 3.0 Panthenol 0.2 0.2 0.2 0.2 Willow extract 0.2 0.2 0.2 0.2 Golden Extract / Peony Root Extract 2.0 2.0 2.0 2.0 Xanthan gum 0.1 0.1 0.1 0.1 glycerin 6.0 6.0 6.0 6.0 Cetearylglucoside 1.0 1.0 1.0 1.0 Glycosyl trehalose 3.0 3.0 3.0 3.0 Purified water 9.97 39.96 54.95 59.95 Citric acid 0.03 0.04 0.05 0.05 High Mineral Mineral Water Extract 50.0 20.0 5.0 -

Skin irritation test of high mineral mineral water extract

Clinical experiments were conducted to determine what irritation of the high mineral mineral water according to the embodiment of the present invention prepared as described above may cause human skin.

Clinical trials were conducted in 20 healthy (10 males, 10 females) between 10 and 70 years of age. Do not use other products such as steroids or antibiotics from 2 weeks before the end of the experiment.

After all the subjects were washed with a problem-free skin area with soap, the high mineral mineral water extract according to the embodiment of the present invention was applied at about 2 mg / cm 2 and the skin condition (erythema, edema, papules, etc.) was 24 hours later. Observations were made, and the results were evaluated qualitatively through an evaluation table as shown in Table 3 below, and the results were as shown in Table 4 below.

Skin irritation evaluation table Experiment item Subjective score Stimulation degree a: The skin is very red, and itching is strong.
b: The skin is slightly red and itchy.
c: The skin is slightly red and irritated.
d: Skin condition remains unchanged but slightly irritating.
e: No irritation or skin condition change.

Skin irritation evaluation results of high mineral mineral water extract Evaluation items
(Skin irritation) Evaluation results No irritation or skin condition change. 17 people Skin condition remains unchanged but slightly irritating 3 people The skin is slightly red and irritated. - The skin is slightly red and itchy. - The skin is very red and itchy. -

As can be seen from the evaluation results of Table 4, it can be seen that the high mineral water extract according to the embodiment of the present invention is a safe substance having little irritation such as erythema.

Skin irritation experiment of cosmetic cream

Next, skin irritation experiments of the cosmetic creams prepared according to Examples 1 to 3 and Comparative Examples of the present invention were performed.

Specifically, the clinical trials were performed on 10 healthy people (20 males, 20 females) between 10 and 70 years old in each of Examples 1 to 3 and Comparative Examples, each of 5 males and 5 females. From the first two weeks before the end of the experiment, other products such as steroids and antibiotics were not used.

After subjecting all the subjects to soap-free skin areas without problem, the cosmetic creams prepared according to Examples 1 to 3 and Comparative Example of the present invention were applied at about 3 mg / cm 2 each and skin condition (erythema, edema) was observed after 24 hours. , Papules, etc.), and qualitative evaluation was performed through the evaluation table of Table 3, as shown in Table 5 below.

Skin irritation evaluation result of cosmetic cream Evaluation item
(Skin irritation degree) Evaluation results Example 1 Example 2 Example 3 Comparative example No irritation or skin condition change. 7 people 7 people 7 people 8 people Skin condition remains unchanged but slightly irritating. 3 people 3 people 3 people 2 people The skin is slightly red and irritated. - - - - The skin is slightly red and itchy. - - - - The skin is very red and itchy. - - - -

As shown in the evaluation results of Table 5, the cosmetic creams prepared according to Examples 1 to 3 and Comparative Examples of the present invention are all just a slight stimulus to a few people without causing erythema or itching A substance that rarely causes skin irritation.

Clinical trial on atopic skin improvement effect

In order to confirm the skin itch improvement effect of the cosmetic cream prepared according to Examples 1 to 3 of the present invention, the clinical trials were carried out as follows for patients with atopic disease.

Clinical trials consisted of 40 patients with skin itching caused by atopic dermatitis between 10 and 50 years old (Examples 1 to 3 and 10 for each of the comparative examples). In addition, no antihistamines should be used.

And all subjects were asked to apply the cosmetic cream to the site of the itch 3 times a day 3mg / ㎠ for 3 months, and then evaluated the condition after 3 months, as shown in Table 6 below, the evaluation results Was as Table 7 below.

Itching Scorecard Experiment item Subjective score Skin itching effect a: greatly improved
b: improved
c: no difference
d: worse
e: very bad

Itching Assessment Results Evaluation item
(Itching Improvement) Evaluation results Example 1 Example 2 Example 3 Comparative example Very improved 7 people 5 people 2 people 3 people Improved 3 people 3 people 5 people 3 people No difference - 2 people 3 people 4 people Worse - - - - Very worse - - - -

As shown in Table 7 above, as a result of evaluation of the skin itch, in the case of Example 1, 7 subjects answered that the skin itch symptom was greatly improved and 3 responded to the improvement. In Example 2, five subjects answered that the skin itch symptom was greatly improved, three were improved, and two were no difference.

In the case of Example 3, two subjects answered that the skin itch symptom was greatly improved, five were improved, and three were no difference.

The amelioration process also began to improve from the 3rd week of use when atopic symptoms persisted for more than 3 years, and improved significantly within 2 months.For patients who developed atopic symptoms less than 1 year, 30 In some cases, the symptoms improved until almost cure. That is, it was confirmed that there was a slight difference in the rate of improvement depending on the duration of symptoms.

In the case of the comparative example does not include the high mineral mineral water extract according to the embodiment of the present invention, three people were very improved, three were improved, and the other four said no typical difference, which is also a comparative example containing natural moisturizer Since it is a cosmetic product, the skin's moisturizing power is increased, and it is shown that it can significantly improve the itching characteristic of atopy. However, if the symptoms are severe, the difference is shown in Examples 1 to 3 of the present invention in that there is no difference before and after application.

Clinical Trial of Infection Symptoms of Atopic Dermatitis

In order to confirm the improvement effect on the symptoms of infection of atopic dermatitis of the cosmetic cream prepared according to Examples 1 to 3 of the present invention, the clinical trials were carried out as follows.

Clinical trials were conducted in 20 patients with skin infections caused by atopic dermatitis between 10 and 50 years old (Examples 1 to 3 and 5 for each of the comparative examples). Do not use any medicine.

All the test subjects were allowed to apply the cosmetic cream 3 times a day for about 3 mg / cm 3 three times a day to infectious areas and then evaluate the condition after 3 months as shown in Table 8 below. It was as Table 9 below.

Atopic Infectious Disease Scorecard Experiment item Subjective score Atopic Dermatitis Infection Symptoms
Improvement effect a: Significantly improved (over 50% improvement)
b: improved (30% improvement)
c: no effect
d: worsen (site and condition worse than 20%)
e: Very deteriorated (site and condition worse than 40%)

Atopy infected person evaluation result Evaluation item
(Amelioration Symptoms of Atopic Dermatitis) Evaluation results Example 1 Example 2 Example 3 Comparative example Very improved 7 people 4 people 2 people 1 person Improved 2 people 4 people 4 people 4 people No difference 1 person 2 people 4 people 5 people Worse - - - - Very worse - - - -

1A and 1B are photographs showing the state before and after applying the cosmetic cream according to Example 1 of the present invention to a 32-year-old woman with inflammation on the skin for 3 months. As can be seen in Figure 1b, most of the seborrheic symptoms in the affected area was removed and it can be seen that the symptoms were significantly alleviated compared to when the symptoms occurred overall. As can be seen in Table 9, according to the evaluation result of the present invention, not only the female but also Example 1 showed an effect of improving seborrheic inflammation in 90% of the subjects. In addition, in the case of Example 2, the improvement effect of 80%, and in the case of Example 3 also showed 60%.

On the other hand, even in the case of the comparative example does not include a high mineral mineral water extract according to an embodiment of the present invention, it can be seen that the action of alleviating inflammation in part by the effect of the natural moisturizer component included in the cream, but the patient It can be seen that the number of significant improvements is significant in comparison with the embodiment of the present invention. In other words, high mineral water extract according to an embodiment of the present invention can be said to play a big role in the relief of atopic or itching.

Claims (6)

Extract of golden, yellow, white, fish, triticale, thirsty mushrooms, licorice and licorice, using mineral water containing more than 10,000 mg / liter of total mineral content of calcium, containing more than 5,000 mg of calcium per liter based on total weight 1 to 70% by weight,
Arachidyl alcohol: 0.5-1.0% by weight,
Behenyl alcohol: 0.5-1.0 wt%,
Arachidylglucoside: 0.5-1.0% by weight,
Cetearyl alcohol: 1.0-2.0% by weight,
Cetearyl olivate: 0.5-1.0 wt%,
Sorbitan sulfate: 0.5-1.0 wt%,
Shea Butter: 1.0-2.0% by weight,
Caprylic, capric triglycerides: 5.0-10.0 wt%,
Calendula flower oil: 1.5-3.0% by weight,
Grape seed oil: 1.0-2.0% by weight,
Jojoba seed oil: 2.0-4.0% by weight,
Olive oil: 1.0-2.0% by weight,
Dimethicone: 0.5-1.0 wt%,
Sodium hyaluronate: 2.0-4.0 wt%,
Beta-glucan: 2.0-4.0 weight percent,
Panthenol: 0.1-0.5% by weight,
Willow extract: 0.1-0.5% by weight,
Peony Root Extract: 1.0-2.0 wt%,
Xanthan gum: 0.1-0.5% by weight,
Glycerin: 5.0-10.0% by weight,
Cetearylglucoside: 1.0-2.0 wt%,
Glycosyl trehalose: 2.0-4.0 wt%,
Citric acid: 0.01-0.2% by weight and
Cosmetic composition for improving skin troubles comprising the remaining purified water. delete delete The method of claim 1,
The extract, the golden extract 0.1 ~ 20.0%, the baekbaek extract: 0.1 ~ 20.0%, the Echochocho extract: 0.1 ~ 20.0%, the triticale extract: 0.1 ~ 20.0%, the neck mushroom extract: 0.1 ~ 30.0%, the Licorice extract: 0.1 to 20.0%, and the licorice extract: cosmetic composition for improving skin troubles, characterized in that it comprises 0.1 to 40.0%. delete delete

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