CN106075120B - A kind of Eczema Creams agent - Google Patents
A kind of Eczema Creams agent Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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Abstract
The invention discloses the Eczema Creams agent of the skin diseases such as a kind for the treatment of eczema of ingredient containing beta glucan, dermatitis, have the effects that sterilization, anti-inflammatory, moisturizing and desalination pigment, it is composed with the composition of raw materials of natural botanical source, for fields such as skin care item, health treatment and medical products.The Eczema Creams agent is made of raw material from the following weight: 2~6 parts of emulsifier, 5~20 parts of crude vegetal, 25~35 parts of beta glucan, 2~10 parts of Purslane extract, 0.1~2 part of arasaponin, 20~80 parts of purified water.
Description
Technical field
The present invention relates to a kind of pharmaceutical preparation for treating skin disease, more particularly to it is a kind of treat eczema, dermatitis it is wet
Rash cream.
Background technique
Eczema is a kind of common anaphylaxis dermatosis, with rubescent, oedema, itch and dry for characterization, can with incrustation,
Peeling, blistering, cracking, bleeding or oozing of blood, the course of disease is irregular, is in recurrent exerbation, acute pruritus.Recently studies have shown that eczema can
Caused by multiple-microorganism infection, staphylococcus aureus, pityrosporum furfur etc. can be detected at eczema skin lesion.Treat eczema
Primary focus is sterilization, antipruritic, anti-inflammatory and moisturizing.Glucocorticoids preparation, tar class are clinically relied primarily at present
Preparation, immunomodulator or antibiotic external preparation treat eczema.But clinically prolonged application hormone and antibiotic, are also easy to produce
The part adverse reaction such as drug resistance, atrophoderma, telangiectasis, pigmentation.
The Chinese medicine composition or Chinese and western medicinal composition for the treatment of eczema have disclosed in the prior art, but prescription is complicated.Such as:
A kind of topical composition and preparation method thereof for treating eczema is disclosed in 101391000 A file of publication number CN,
Composite formula in percentage by weight is 1%-10% Pollen Pini extract, 1%-10% Pollen Tyjphae extract and 1%-
10% Spora Lygodii extract, wherein the content of Pollen Pini extract, Pollen Tyjphae extract and Spora Lygodii extract in the composition is total
With should include talcum powder, stearic acid, borneol, menthol, glycerin monostearate, sodium alginate, card wave in 5%-30%, auxiliary agent
Nurse, triethanolamine, glycerol, vegetable oil, azone etc..
Externally applied anti-inflammation antipruritic ointment preparation and preparation method thereof is disclosed in 102861271 A file of publication number CN, according to
Weight ratio its composition proportion be kuh-seng 20-50 parts, 10-20 parts of frutus cnidii, 20-30 parts of the fruit of summer cypress, 20-30 parts of Cortex Phellodendri, rhizoma atractylodis
20-30 parts, 20-40 parts of smilax, 10-20 parts of alumen, appropriate menthol, and after needing to be extracted repeatedly with 70% dehydrated alcohol
It can be made into.
A kind of external application Chinese medicine for treating eczema is disclosed in 102861274 A file of publication number CN, according to its group of weight ratio
Object is closed to match as Radix Astragali 20-30 parts, 10-20 parts of radix saposhnikoviae, 10-20 parts of paniculate swallowwort, 10-20 parts of rhizoma atractylodis macrocephalae, 10-20 parts of schizonepeta, hardship
Join 10-20 parts, 15-25 parts of Semen Coicis, 10-20 parts of cicada slough, 6-15 parts of Radix Glycyrrhizae, 15-25 parts of Golden Larch Bark, 10-25 parts of smilax, cnidium monnieri
20-30 parts sub-, 10-20 parts of peppermint, 10-20 parts of radix scutellariae, 20-30 parts of cortex dictamni.
A kind of Chinese materia medica preparation for treating eczema is disclosed in 104706824 A file of publication number CN, according to its group of weight ratio
Closing object proportion is 8 parts of olibanum, 7 parts of rhizoma atractylodis, 8 parts of Cortex Eucommiae, 5 parts of cortex dictamni, 18 parts of Radix Polygalae, 5 parts of frutus cnidii, 3 parts of folium isatidis, gold and silver
Spend 8 parts, 0.5 part of semen plantaginis.
Summary of the invention
The present invention provides a kind of eczema ointment for treating the skin diseases such as eczema, dermatitis, using natural materials source as raw material system
At, formula combination is simple, and it can sterilize, is antipruritic, anti-inflammatory and moisturizing, and having the function of antiallergy and repair impaired skin,
Performance is mild, it is non-stimulated to skin, without side-effects, do not generate drug resistance, be easy to use and environmentally protective, especially suitable for motherhood
Woman, infant and high-risk sensitive group.
To achieve the above object, the technical solution adopted by the present invention is that: a kind of Eczema Creams agent containing beta glucan, including
Following raw material:
25-35 parts of beta glucan, 2-10 parts of Purslane extract, 0.1-2 parts of arasaponin, crude vegetal 5-20
Part, 2-6 parts of emulsifier, 20-80 parts of purified water.
The emulsifier is to be formulated by following three kinds of raw materials by the parts by weight: 0.5-3 parts of cetostearyl alcohol, spermaceti
1-5 parts of stearyl glucoside, 1-6 parts of glycerin monostearate.
The crude vegetal is formulated by any two to five kinds in following six kinds of raw materials with following parts by weight:
0.1~8 part of shea butter；
0.1~8 part of wheat-germ oil；
0.1~8 part of grape seed oil；
0.1~8 part of caryophyllus oil；
0.1~8 part of olive oil；
0.1~8 part of perilla herb oil.
Preferably, the purified water is distilled water or deionized water.
The present invention is using the beneficial effect and advantage of aforementioned schemes:
1. the raw material using natural materials as source, mildly can act on skin after centainly matching non-stimulatedly,
The effect of playing sterilization, antipruritic, anti-inflammatory and moisturizing.
Wherein:
Beta glucan is with 1,3 glycosidic bond for main chain, and 1,6 glycosidic bond is the naturally occurring polysaccharide of side chain, with patent
Method described in 201510725996.7 file of application number obtains, i.e., from schizophyllum commune fermentation extraction.It is thin to can be improved skin
The multiplication rate of born of the same parents, promotes the generation of collagen and elastin laminin, and help updates and repairs impaired skin, promotes being cured for scar
It closes；Keep moisture of skin, improve skin moisturizing degree and compact smoothness；Effectively inhibit histamine release of mast cell and de-
Grain effect, sensitive skin of releiving reduce chafing.
Purslane extract be from the stem and leaf of purslane, with low-temperature extraction method obtain bioactive substance, it is molten
Solution is made in 39.5% butanediol solution, has broad-spectrum antiseptic and anti-inflammatory, anti-allergic effects, and can promote epithelial cell
Physiological function is replied.
Arasaponin is the effective component that separation is extracted from high-quality Radix Notoginseng, including more than 20 kinds of saponin(e active materials, 17
Kind microelement, albumen, vitamin abundant, polysaccharide etc., have and remove free radical, anti-inflammatory, antioxidation, improve local skin
The blood circulation and metabolism of skin, enhance the immunity of skin, and accelerating wound healing repairs inflammation and is damaged skin.
Shea butter has effects that promote skin regeneration, prevents light aging, to the skin with dermatitis, sunburn and scar
There is apparent promotion Healing.There are good long-term moistening effect, its spreadability and percutaneous absorbability to the surface layer of skin
It is all fairly good, especially suitable for without greasy formula, epidermis is moistened in stimulation of releiving.
Wheat-germ oil vitamin E rich in and vitamin B complex, vitamin E have holding moisture, skin of moistening
Function protects lipid and protein in Skin Cell film, so that it is played the effect in conjunction with moisture, maintains the normal generation of cell
It thanks, and the microcirculation of skin can be improved, enhance the immunity of skin；Vitamin B complex includes vitamin B1, B2, B6 etc., is to constitute
The component of the necessary protease of skin metabolism, at the same can activated epithelial, anti-inflammatory moisturizing, alleviate pachylosis situation.
Grape seed oil can be promoted the appropriately crosslinked of collagen, be prevented skin from wrinkle and capsule occur with skin nutrition cell
The coarse and angling of bubble and skin, and have the function of removing free radical, accelerate skin metabolism, protects skin epidermis
Cell and neonatal cell；Moisture of skin is kept, and the oiliness skin-friendly of oil is strong, is easily absorbed by the skin, various skin is suitble to use.
The medical value of caryophyllus oil is mainly embodied by eugenol, the polar group on aromatic rings in chemical structure, energy
In conjunction with the active group of enzymes certain in microorganism, the normal metabolic function of microorganism is destroyed, reaches the work for inhibiting fungi, bacterium
With.Caryophyllus oil can promote Drug Percutaneous Absorption.
The more other oils of vitamin type and quantity contained by olive oil are obviously more, and such as wherein vitamin A (and A is former) has
Play the role of making skin smooth, delicacy and increase its elasticity, vitamin B1 has the function of flattening skin fine corrugations, vitamin
C has the effects that enhance vessel wall elasticity, expands blood flow.
Alpha-linolenic acid is rich in perilla herb oil, alpha-linolenic acid has the work for inhibiting platelet activating factor and leukotriene to generate
With to have effects that anti-allergic inflammation.
Choosing above-mentioned crude vegetal is cream base, can make full use of crude vegetal and disappears to skin moisture-keeping sterilization
The effects of scorching, promotion skin injury is healed, auxiliary main ingredient plays drug effect.
2. the raw material that the present invention uses obtains simplicity, Purslane extract and arasaponin are commercially available,
Beta glucan belongs to a kind of exocellular polysaccharide, and source is various, such as mushroom, schizophyllum commune, ganoderma lucidum, yeast etc., to split pleat in the present invention
Source strain of the bacterium as beta glucan, i.e., from schizophyllum commune fermentation extraction.Schizophyllum commune is wide in China's distributional region, strain
Resource is very rich.Main ingredient formula of the present invention is simple, and 3 kinds of raw material prescriptions is taken to be formed.Therefore before there is scale application
Scape.
Specific embodiment
Carry out the embodiment that the present invention will be described in detail below with reference to specific embodiment, how skill is applied to the present invention whereby
Art means solve technical problem, and the realization process for reaching technical effect can fully understand and implement.
Unless otherwise specified, the conventional hand that technological means employed in embodiment is well known to those skilled in the art
Section, used reagent and product are also available commercial.The source of agents useful for same, trade name and it is necessary to list it
Constituent person is indicated on the first occurrence.
Embodiment one
A kind of Eczema Creams agent, including following raw material:
25 parts of beta glucan
2 parts of Purslane extract
0.2 part of arasaponin
3 parts of wheat-germ oil
3 parts of grape seed oil
0.5 part of cetostearyl alcohol
1 part of cetearyl glucoside
1 part of glycerin monostearate
30 parts of distilled water
Embodiment two
A kind of Eczema Creams agent, including following raw material:
35 parts of beta glucan
8 parts of Purslane extract
1 part of arasaponin
5 parts of shea butter
2 parts of wheat-germ oil
3 parts of grape seed oil
8 parts of olive oil
0.5 part of perilla herb oil
2 parts of cetostearyl alcohol
3 parts of cetearyl glucoside
1 part of glycerin monostearate
80 parts of distilled water
Embodiment three
A kind of Eczema Creams agent, including following raw material:
28 parts of beta glucan
3 parts of Purslane extract
0.3 part of arasaponin
2.5 parts of wheat-germ oil
0.5 part of caryophyllus oil
4 parts of olive oil
0.6 part of cetostearyl alcohol
1 part of cetearyl glucoside
1 part of glycerin monostearate
40 parts of distilled water
Example IV
A kind of Eczema Creams agent, including following raw material:
32 parts of beta glucan
6 parts of Purslane extract
0.8 part of arasaponin
4 parts of shea butter
4 parts of wheat-germ oil
3 parts of perilla herb oil
2 parts of cetostearyl alcohol
1 part of cetearyl glucoside
1 part of glycerin monostearate
60 parts of deionized water
Embodiment five
A kind of Eczema Creams agent, including following raw material:
30 parts of beta glucan
5 parts of Purslane extract
0.5 part of arasaponin
3 parts of shea butter
1 part of grape seed oil
3 parts of olive oil
2 parts of perilla herb oil
0.6 part of cetostearyl alcohol
1.3 parts of cetearyl glucoside part
1 part of glycerin monostearate
52.5 parts of deionized water
The present embodiment is optimal case of the present invention.
Drug test
The present invention has carried out animal experiment about inflammatory symptom inhibiting effect and skin irritation.Research process is as follows:
Test material: small white mouse, 18~22g, half male and half female；Rat, 160~180g, half male and half female.
Drug and reagent: eczema ointment, dimethylbenzene, vaseline
Research method 1: the influence of paraxylene induced mice auricle edema
18~22g Kunming mouse 30 are taken, is randomly divided into two groups, every group 15, half male and half female, respectively control group,
Eczema ointment group, control group are coated with excipient (vaseline), remaining group is coated with relative medicine in mouse right ear respectively, 0.5g/ only, often
Day 2 times, for three days on end, 1 hour each group washes away drug with distilled water after the 4th day coating, is cleaned with dry cotton ball.Then each group mouse
Auris dextra is coated with dimethylbenzene 0.05ml/ only, and left ear compares, and puts to death animal after 30 minutes, with 8mm punch that mouse or so ear is same
Equal positions homalographic is cut, and is weighed with electronic balance, using the difference of left and right auricle weight as swelling, is calculated each group swelling, is asked
Swelling inhibiting rate out, the result is as follows:
Note: compared with the control group, p < 0.05 *
The result shows that the substantially reduced dimethylbenzene induced mice ear swelling of eczema ointment energy, has mouse ear swelling inflammation
Obvious inhibiting effect.
Research method 2: to the local stimulation test of rat intact skin
Rat 10 are taken, 2 pieces of hair-fields is gone to what curved scissors cut 2.5cm x 2.5cm in back backbone two sides, pays attention to not damaging
Hurt skin.Every piece of unhairing area is coated with 0.5g eczema ointment and 0.5g matrix (vaseline) respectively when test, with one layer of oilpaper and bilayer
Immobilization with adhesive tape after gauze covering.Scrub water is used after 24 hours, removes remaining ointment and vaseline, and observation removes 1 after left drug
The skin wound repair (whether there is or not erythema, oedema at coating position) of hour, 24 hours, 48 hours and 72 hours carry out integral estimation
As a result, hair-fields skin is respectively gone to have no the stimulate the reactions such as erythema, oedema, integrated value 0.Show eczema ointment to rat intact skin without
Irritation.
Claims (6)
1. a kind of Eczema Creams agent, which is characterized in that be made of following weight parts raw material:
25-35 parts of beta glucan, 2-10 parts of Purslane extract, 0.1-2 parts of arasaponin, 5-20 parts of crude vegetal, cream
2-6 parts of agent, 20-80 parts of purified water.
2. the Eczema Creams agent according to claim 1, which is characterized in that the emulsifier presses institute by following three kinds of raw materials
It states parts by weight to be formulated: 0.5-3 parts of cetostearyl alcohol, 1-5 parts of cetearyl glucoside, 1-6 parts of glycerin monostearate.
3. Eczema Creams agent according to claim 1, which is characterized in that the crude vegetal is by following six kinds of raw materials
Any two to five kinds be formulated with following parts by weight:
0.1~8 part of shea butter；
0.1~8 part of wheat-germ oil；
0.1~8 part of grape seed oil；
0.1~8 part of caryophyllus oil；
0.1~8 part of olive oil；
0.1~8 part of perilla herb oil.
4. Eczema Creams agent according to claim 1, it is characterised in that: the purified water is distilled water or deionized water.
5. Eczema Creams agent according to claim 1, it is characterised in that: in parts by weight, be made of following raw materials: β-Portugal
28-32 parts of glycan, 3-7 parts of Purslane extract, 0.3-0.8 parts of arasaponin, 7-12 parts of crude vegetal, emulsifier 2-4
Part, 40-60 parts of purified water.
6. Eczema Creams agent according to claim 1, it is characterised in that: in parts by weight, be made of following raw materials: β-Portugal
It is 30 parts of glycan, 5 parts of Purslane extract, 0.5 part of arasaponin, 3 parts of shea butter, 1 part of grape seed oil, 3 parts of olive oil, purple
2 parts, 0.6 part of cetostearyl alcohol, 1.3 parts of cetearyl glucoside, 1 part of glycerin monostearate, 52.5 parts of purified water of Soviet Union's oil.
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| WO2021243259A1 (en) * | 2020-05-29 | 2021-12-02 | Waller Edmund | Hair growth compositions |
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| CN109010403A (en) * | 2018-10-24 | 2018-12-18 | 王秀国 | A kind of health care eczema ointment |
| CN109125146B (en) * | 2018-11-06 | 2021-05-18 | 南京中医药大学 | Composition of ganoderma lucidum polysaccharide and clove oil |
| CN110025569A (en) * | 2019-05-16 | 2019-07-19 | 吉林农业科技学院 | A kind of Polysaccharide from Portulaca oleracea emulsifiable paste and preparation method thereof |
| CN111973620B (en) * | 2019-05-21 | 2024-04-16 | 浙江立恩生物科技有限公司 | Biological polysaccharide for preventing and treating hormone-dependent dermatitis and application thereof |
| CN111713625A (en) * | 2020-06-12 | 2020-09-29 | 江苏微康生物科技有限公司 | Bacillus coagulans solid beverage with efficacy of relieving eczema and preparation method thereof |
| CN114432380A (en) * | 2022-02-25 | 2022-05-06 | 李楠 | Traditional Chinese medicine and probiotic composition of cream for treating eczema and preparation process of traditional Chinese medicine and probiotic composition |
| CN115737474B (en) * | 2022-08-30 | 2023-11-10 | 江苏长泰药业股份有限公司 | Preparation method of glucan emulsion, composition containing glucan emulsion and application of composition |
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