CN101468070A - Medicinal composition for treating acne and preparation method thereof - Google Patents
Medicinal composition for treating acne and preparation method thereof Download PDFInfo
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- CN101468070A CN101468070A CNA2007100602966A CN200710060296A CN101468070A CN 101468070 A CN101468070 A CN 101468070A CN A2007100602966 A CNA2007100602966 A CN A2007100602966A CN 200710060296 A CN200710060296 A CN 200710060296A CN 101468070 A CN101468070 A CN 101468070A
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Abstract
The invention discloses a medicine for treating acne, mainly composed of rhubarb, radix salviae miltiorrhizae and alkanna tinctoria prepared according to a certain ratio by weight. The medicine can be prepared as external preparation with heat-clearing and fire-purging, anti-inflammation, antibiosis, wound-healing promoting function and high curative effect on acne and high curative ratio.
Description
Technical field
The present invention relates to a kind of drug regimen for the treatment of acne and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Acne is a kind of pilosebaceous chronic inflammatory disease, and good sending out in face, chest and back can form infringements such as acne, pimple, pustule, tuberosity, cyst, is mainly in the adolescence men and women, often with seborrhea.Acne belongs to Chinese medicine acne category, and morbidity is relevant with factors such as insufficiency of the spleen leading to overabundance of dampness, the long-pending heat of lung stomach, stagnation of QI due to depression of the liver, and spleen-deficient is many because of eating and drinking without temperance, the sweet fertilizer of happiness food, and impairing the spleen and stomach is made humidogene heat, ties in the intestines and stomach, follows on the Yangming Channel and steams due to the face.Modern medicine thinks that acne is fallen ill main and the sebum generation increases, and the propionibacterium acnes breeding is relevant in follicular epithelium hyperkeratosis and the hair follicle.Acne is a kind of common skin disease, is chronic process, easily recurrence.Good sending out in adolescence influences acne cystica attractive in appearance, serious and acne conglobata may stay cicatrix, brings negative effect for patients ' psychological and social communication.
Summary of the invention
The inventor is through research repeatedly, and the checking repeatedly by clinical trial, thereby has obtained having the external used medicine of better healing acne to finish the present invention finally.
The object of the invention just provides a kind of a kind of Chinese medicine composition of more effectively treating acne.
Another object of the present invention has provided the preparation method of this Chinese medicine composition.
Medicament selection Radix Et Rhizoma Rhei of the present invention, Radix Salviae Miltiorrhizae, Radix Arnebiae (Radix Lithospermi) make up, and make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of acne.Wherein select for use Radix Et Rhizoma Rhei be because Radix Et Rhizoma Rhei in Radix Et Rhizoma Rhei total free anthraquinones to acne main pathogenic bacterium---propionibacterium acnes, staphylococcus aureus all have obvious suppression effect, particularly emodin to show stronger inhibitory action.Select for use Radix Salviae Miltiorrhizae to be because one of water-soluble monomer of Radix Salviae Miltiorrhizae---danshensu; the effect of removing is better than SOD; salvianolic acid A, B; danshensu; Herba Rosmarini Officinalis thujic acid etc. all has significant protective effect to the biomembrane peroxide injury; especially with the antioxidant activity of salvianolic acid A for the strongest, than the strong Radix Achyranthis Bidentatae to thousand of vitamin E times.Radix Salviae Miltiorrhizae makes endotheliocyte not be subjected to lipid peroxidation injury by protection SOD is active with the removing oxygen-derived free radicals, has the inhibited oxidation modified LDL and reduces MDA content among the LDL, and is close with the effect of vitamin E.Select Radix Arnebiae (Radix Lithospermi) to be because Radix Arnebiae (Radix Lithospermi) has removing heat from blood, invigorates blood circulation, antipyretic and antidote functions, can quicken epithelial growth and treatment burn and scald, suppress capillary permeability.Wherein the effective ingredient Acetyl-shikonin Acetylshikonin has antibiotic, antiinflammatory action, and staphylococcus aureus and various skin fungus are had inhibitory action, and the topical application Acetyl-shikonin Acetylshikonin can promote wound healing.This three flavors medicine combination can suppress the main pathogenic bacterium of acne jointly, promotes the healing of skin infection face.
In order to reach better effect, medicine of the present invention also makes up with Cortex Phellodendri, Rhizoma Curcumae Longae, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Radix Glycyrrhizae.This is because Cortex Phellodendri bitter in the mouth, cold in nature is returned kidney, urinary bladder channel.The energy heat clearing and damp drying, eliminating fire and detoxication, detumescence putrefaction removing.Cortex Phellodendri has inhibitory action in the activity to propionibacterium acnes lipase.The curcumin that is contained in the Rhizoma Curcumae Longae (curcumin) can suppress superoxides and generate, thereby reduces H
2O
2Cause cytotoxicity, the human keratinocyte is shielded.Can obviously reduce the roughness of human body face skin, be the active drug of delaying decrepitude of skin; And can absorb ultraviolet, prevent skin darkening, have the effect of the skin regeneration of promotion, treatment burn, scald, skin ulcer are also had certain curative effect.Pericarpium Citri Reticulatae extract has tangible removing oxygen-derived free radicals, hydroxy radical and lipoid peroxidization resistant, and the cell membrane oxidative damage that free radical is caused has protective effect.Its ethyl acetate extract---nobiletin has the effect of obvious suppression tyrosinase activity, and hesperidin can prevent that ultraviolet from causing the peroxidating of Skin Cell lipid and the erythema and the skin carcinoma that cause.Rhizoma Atractylodis, Cortex Magnoliae Officinalis have the obvious suppression effect to staphylococcus aureus, staphylococcus epidermidis, acne Acne.Glycyrrhizic acid in the Radix Glycyrrhizae and derivant thereof have the nourishing skin, suppress the effect of inflammatory reaction; Glycyrrhizin have antiulcer, antiinflammatory pharmacological action.Many external curings of Radix Glycyrrhizae contact dermatitis, allergic dermatitis, eczema, chapped skin etc.These several herbal medicines are auxiliary antibacterial, and the opposing ultraviolet prevents the stimulation of ultraviolet to skin, the restraint of tyrosinase activity, thus play protection, skin whitening, promote the effect that acne is cured.
The specific embodiment
Experimental example 1
The clinical observation of Drug therapy acne of the present invention
1, inclusion criteria
Determine diagnostic criteria with reference to " new Chinese medicine clinical research guideline ".1. pubarche morbidity is sent out in face well, is gone up the flourishing position of sebums such as breast and back, symmetrical distribution.2. skin lesion is hair follicle pimple, blackhead, pustule, tuberosity, cyst and cicatrix, with seborrhea, is chronic process.
2, physical data
This is organized 120 examples and all meets above inclusion criteria, wherein male 40 examples, women 80 examples; The oldest 38 years old, minimum 18 years old, average (21 ± 3.58) year; The course of disease 1 month～5 years.MethodsThe cases enrolled is divided into treatment group 60 example and matched group 60 examples at random, and two groups of patient's physical data are learned by statistics and are handled no significant difference (P＜0.05), have comparability.
3, Therapeutic Method
3.1 the treatment by Chinese herbs group is applied to the acne affected part outward with the Chinese medicine facial cream, observes weekly 1 time every day each 1 time sooner or later, 4 weeks were 1 course of treatment (or to erythra disappear fully).Clean face with clear water before the medication, do not add wrapping, note this medicine not being applied to ophthalmic.
Table 1 liang group treatment 4 all backs curative effects are (example) relatively
Annotate: two groups of curative effects compare, * P＜0.05,
*P〉0.05
3.2, western medicine group 0.025% tretinoin emulsifiable paste is applied to the acne affected part outward, observes weekly 1 time every day each 1 time sooner or later, 4 weeks were 1 course of treatment (or to erythra disappear fully).Clean face with clear water before the medication, do not add wrapping, note this medicine not being applied to ophthalmic.
3.3,2 weeks of the course of treatment are 1 course of treatment, add up curative effect after 2 courses of treatment.More than two groups all avoid higher fatty acid and Hi CHO food.
4, criterion of therapeutical effect
Recovery from illness: skin lesion disappears fully, does not have new erythra and takes place; Produce effects: skin lesion disappears more than 75%, and idol has new erythra to take place; Effectively: skin lesion disappears between 50%～75%; Invalid: skin lesion only has slightly to disappear or do not have and is clearly better.Total effective rate adds produce effects in healing and reaches effectively.Treatment group and matched group cure rate and effective percentage relatively adopt χ
2Check.
5, therapeutic outcome
Two groups of patient treatment 4 all backs curative effects relatively see Table 1, learn by statistics and handle, and treatment group and matched group cure rate difference have significance (X
2=4.09, P＜0.05), effective percentage difference does not have significance (X
2=0.08, P〉0.05).
Experimental example 2
1) Radix Et Rhizoma Rhei 25g, Radix Salviae Miltiorrhizae 25g two flavor medicines are decocted twice with 10 times of water gagings, each 1.5 hours, merge decocting liquid twice, filter, filtrate is concentrated into half volume in right amount, filter, get Chinese medicine extraction liquid 1;
2) Radix Arnebiae (Radix Lithospermi) 25g is extracted 2 times with 5 times of amount 80% glycerol, each 1.5 hours, merge decocting liquid twice, filter, get Chinese medicine extraction liquid 2;
3) merge Chinese medicine extraction liquid 1 and Chinese medicine extraction liquid 2, it as water, is added cream base and make cream.
Experimental example 3
1) Radix Et Rhizoma Rhei 25g, Radix Salviae Miltiorrhizae 25g, Cortex Phellodendri 20g, Rhizoma Atractylodis 10g, Cortex Magnoliae Officinalis 10g, Radix Glycyrrhizae 10g are decocted twice with 10 times of water gagings, each 1.5 hours, merge decocting liquid twice, filter, filtrate is concentrated into half volume in right amount, filter, get Chinese medicine extraction liquid 1;
2) with Radix Arnebiae (Radix Lithospermi) 25g, Rhizoma Curcumae Longae 20g, Pericarpium Citri Reticulatae 10g, extract 2 times with 5 times of amount 80% glycerol, each 1.5 hours, merge decocting liquid twice, filter, Chinese medicine extraction liquid 2;
3) merge Chinese medicine extraction liquid 1 and Chinese medicine extraction liquid 2, it as water, is added emulsion bases and make Emulsion.
Experimental example 4
1) Radix Et Rhizoma Rhei 25g, Radix Salviae Miltiorrhizae 25g, Cortex Phellodendri 20g, Rhizoma Atractylodis 10g, Cortex Magnoliae Officinalis 10g, Radix Glycyrrhizae 10g are decocted twice with 10 times of water gagings, each 1.5 hours, merge decocting liquid twice, filter, filtrate is concentrated into half volume in right amount, filter, get Chinese medicine extraction liquid 1;
2) with Radix Arnebiae (Radix Lithospermi) 25g, Rhizoma Curcumae Longae 20g, Pericarpium Citri Reticulatae 10g, extract 2 times with 5 times of amount 80% glycerol, each 1.5 hours, merge decocting liquid twice, filter, Chinese medicine extraction liquid 2;
3) merge Chinese medicine extraction liquid 1 and Chinese medicine extraction liquid 2, it as water, is added gel-type vehicle and make gel.
Claims (8)
1. treat drug regimen of acne and preparation method thereof for one kind, it is characterized in that, said composition is to be made by following raw material: 1～50 part of Radix Et Rhizoma Rhei, 1～50 part of Radix Salviae Miltiorrhizae, 1～50 part of Radix Arnebiae (Radix Lithospermi).
2. according to the medicine of claim 1, wherein the consumption of each raw material is: 25 parts of Radix Et Rhizoma Rhei, 25 parts of Radix Salviae Miltiorrhizaes, 25 parts of Radix Arnebiae (Radix Lithospermi)s.
3. the preparation method of claim 1 or 2 described medicines, it comprises the following steps:
1) take by weighing each crude drug Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, Radix Arnebiae (Radix Lithospermi), standby;
2) Radix Et Rhizoma Rhei, the Radix Salviae Miltiorrhizae two flavor medicines with described weight proportion decoct twice with 10 times of water gagings, and each 1.5 hours, merge decocting liquid twice, filter, filtrate is concentrated into half volume in right amount, filter, get Chinese medicine extraction liquid 1;
3) Radix Arnebiae (Radix Lithospermi) of described weight proportion is extracted 2 times with 5 times of amount 80% glycerol, each 1.5 hours, merge decocting liquid twice, filter, get Chinese medicine extraction liquid 2;
4) merge Chinese medicine extraction liquid 1 and Chinese medicine extraction liquid 2, obtain the active component of medicine of the present invention.
4. according to the described medicine of claim 1, wherein crude drug also has: 1～50 part of Cortex Phellodendri, 1～50 part in Rhizoma Curcumae Longae, 1～20 part of Pericarpium Citri Reticulatae, 1～20 part of Rhizoma Atractylodis, 1～20 part of Cortex Magnoliae Officinalis, 1～20 part in Radix Glycyrrhizae.
5. according to the described medicine of claim 4, wherein the consumption of each component is: 25 parts of Radix Et Rhizoma Rhei, 25 parts of Radix Salviae Miltiorrhizaes, 25 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts of Cortex Phellodendris, 20 parts in Rhizoma Curcumae Longae, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Rhizoma Atractylodis, 10 parts of Cortex Magnoliae Officinalis, 10 parts in Radix Glycyrrhizae.
6. according to the preparation method of claim 4 or 5 described medicines, it comprises the following steps:
1) take by weighing each crude drug Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, Radix Arnebiae (Radix Lithospermi), Cortex Phellodendri, Rhizoma Curcumae Longae, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Radix Glycyrrhizae, standby;
2) Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, Cortex Phellodendri, Rhizoma Atractylodis, Cortex Magnoliae Officinalis, the glycyrrhizic liuwei drug with described weight proportion decocts twice with 10 times of water gagings, and each 1.5 hours, merge decocting liquid twice, filter, filtrate is concentrated into half volume in right amount, filter, get Chinese medicine extraction liquid 1.
3) Radix Arnebiae (Radix Lithospermi), Rhizoma Curcumae Longae, the Pericarpium Citri Reticulatae with described weight proportion extracts 2 times with 5 times of amount 80% glycerol, and each 1.5 hours, merge decocting liquid twice, filter, get Chinese medicine extraction liquid 2.
4) merge Chinese medicine extraction liquid 1 and Chinese medicine extraction liquid 2, obtain the active component of medicine of the present invention.
7. the preparation method of the described medicine of claim 6, the active component that wherein step 4) is made add emulsion bases and make Emulsion.
8. the preparation method of the described medicine of claim 6, the active component that wherein step 4) is made add gel substrate and make gel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100602966A CN101468070A (en) | 2007-12-27 | 2007-12-27 | Medicinal composition for treating acne and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100602966A CN101468070A (en) | 2007-12-27 | 2007-12-27 | Medicinal composition for treating acne and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN101468070A true CN101468070A (en) | 2009-07-01 |
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|---|---|---|---|
| CNA2007100602966A Pending CN101468070A (en) | 2007-12-27 | 2007-12-27 | Medicinal composition for treating acne and preparation method thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732425B (en) * | 2010-01-19 | 2011-08-10 | 上海市浦东新区三林镇高欣皮肤科诊所 | Externally-applied medicine composite for psoriasis |
| CN102895316A (en) * | 2012-10-23 | 2013-01-30 | 深圳市英杰汇生物科技有限公司 | Face cleanser for treating and preventing acne and preparation method thereof |
| CN103127281A (en) * | 2011-11-22 | 2013-06-05 | 吉林省第二荣复军人医院 | Drug for treating acne |
| CN104510673A (en) * | 2014-12-17 | 2015-04-15 | 刘长华 | Preparation method for acne removing mask |
| CN104522542A (en) * | 2014-12-17 | 2015-04-22 | 刘长华 | Anti-acne mask |
| CN104784541A (en) * | 2015-04-23 | 2015-07-22 | 上海应用技术学院 | Traditional Chinese medicinal medicament for removing acnes and preparation method thereof |
| CN104800629A (en) * | 2015-04-23 | 2015-07-29 | 上海应用技术学院 | Acne eliminating cream for eliminating acnes |
| CN108904425A (en) * | 2018-08-23 | 2018-11-30 | 广州乐草元生物科技有限公司 | A kind of pox-removing face mask |
| CN111529440A (en) * | 2020-04-22 | 2020-08-14 | 重庆市中药研究院 | Preparation method of acne-removing emulsion |
| CN115154571A (en) * | 2022-08-18 | 2022-10-11 | 西南民族大学 | Antibacterial composition and application thereof |
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- 2007-12-27 CN CNA2007100602966A patent/CN101468070A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732425B (en) * | 2010-01-19 | 2011-08-10 | 上海市浦东新区三林镇高欣皮肤科诊所 | Externally-applied medicine composite for psoriasis |
| CN103127281A (en) * | 2011-11-22 | 2013-06-05 | 吉林省第二荣复军人医院 | Drug for treating acne |
| CN103127281B (en) * | 2011-11-22 | 2014-12-10 | 吉林省第二荣复军人医院 | Drug for treating acne |
| CN102895316A (en) * | 2012-10-23 | 2013-01-30 | 深圳市英杰汇生物科技有限公司 | Face cleanser for treating and preventing acne and preparation method thereof |
| CN104510673A (en) * | 2014-12-17 | 2015-04-15 | 刘长华 | Preparation method for acne removing mask |
| CN104522542A (en) * | 2014-12-17 | 2015-04-22 | 刘长华 | Anti-acne mask |
| CN104784541A (en) * | 2015-04-23 | 2015-07-22 | 上海应用技术学院 | Traditional Chinese medicinal medicament for removing acnes and preparation method thereof |
| CN104800629A (en) * | 2015-04-23 | 2015-07-29 | 上海应用技术学院 | Acne eliminating cream for eliminating acnes |
| CN104784541B (en) * | 2015-04-23 | 2018-05-01 | 上海应用技术学院 | It is a kind of to be used to remove Chinese drugs agentia of acne and preparation method thereof |
| CN104800629B (en) * | 2015-04-23 | 2018-05-01 | 上海应用技术学院 | A kind of osteophyte-eliminating ointment and preparation method thereof |
| CN108904425A (en) * | 2018-08-23 | 2018-11-30 | 广州乐草元生物科技有限公司 | A kind of pox-removing face mask |
| CN111529440A (en) * | 2020-04-22 | 2020-08-14 | 重庆市中药研究院 | Preparation method of acne-removing emulsion |
| CN115154571A (en) * | 2022-08-18 | 2022-10-11 | 西南民族大学 | Antibacterial composition and application thereof |
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Open date: 20090701 |