CN104800629A - Acne eliminating cream for eliminating acnes - Google Patents
Acne eliminating cream for eliminating acnes Download PDFInfo
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- CN104800629A CN104800629A CN201510197441.XA CN201510197441A CN104800629A CN 104800629 A CN104800629 A CN 104800629A CN 201510197441 A CN201510197441 A CN 201510197441A CN 104800629 A CN104800629 A CN 104800629A
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Abstract
The invention discloses an acne eliminating cream for eliminating acnes. The acne eliminating cream comprises Chinese herb extracts, an emulsifier, stearic acid, mineral oil, polydimethylsiloxane, glycerol, deionized water, EDTA disodium salt, essence and a preservative, wherein the Chinese herb extracts comprise raw material medicines of rheum officinale, rhizoma curculiginis, lalang grass rhizome, violet magnolia, peppermint, honey, folium isatidis, vernonia patula, campsis flos, loofah sponge, ampelopsis radix, radix sanguisorbae, radix salviae miltiorrhizae, alisma, polygoni avicularis herba, torreyae semen, viticis negundo folium, radix glehniae and reed rhizome, and the mass percent of the components is as follows: 0.5-1.5% of Chinese herb extracts, 1-2% of the emulsifier, 1-2% of stearic acid, 6-8% of mineral oil, 2-3% of polydimethylsiloxane, 8-10% of glycerol, 0.05-0.1% of EDTA disodium salt, 0.3-0.6% of essence, 0.1-0.3% of the preservative and the balance of deionized water. The invention further provides a preparation method for the acne eliminating cream. The acne eliminating cream can remove acnes, and is good in effect and less in side effect.
Description
Technical field
The invention belongs to field of medicaments, particularly relate to a kind of osteophyte-eliminating ointment eliminating acne and preparation method thereof.
Background technology
Acne are equivalent to the acne vulgaris of modern medicine, that the chronic inflammatory skin that a kind of multifactor functioning causes in pilosebaceous unit is sick, be apt to occur in youth of both sexes, it is a kind of psychosomatic disease that can not be ignored, seriously affect the study of patient, work, motion, inter personal contact and social life, the quality of life of patient is declined.Acne mainly betide adolescence, and sickness rate is high, and the cause of disease is complicated.
Modern medicine thinks to be increase with Serum Testosterone Levels in adolescence body, the factors such as smegma is vigorous, drainage difficulty about etc. multifactor caused hair follicle sebum disease, comprise hair follicle sebum supersecretion, follicular orifice hyperkeratosis, the propionibacterium propagation of acne, excessive immunoreation, also relevant with heredity and psychological factor.The traditional Chinese medical science think this disease with wind and heat in the lung meridian, damp and hot, phlegm-damp accumulation symptom, heat in blood, blood stasis etc. are relevant.
In recent years, along with developing rapidly of aesthetic medicine, the treatment of acne has had significant progress, and western medical treatment acne mainly reduce the secretion of sebaceous gland, and the sexually transmitted disease (STD) that diminishes inflammation becomes, and to antiandrogen, prevents cyst from being formed.In recent years the minocycline reported, adapalene gel, Benzamycin agent Acne treatment obtain good therapeutic effect, but how much there is the skin irritation symptom such as erythema, pimple, scorching hot, desquamation, drying.
The primary disease origin cause of formation, corynebacterium acnes is there is in pilosebaceous unit, white plain staphylococcus and oval pityriasis sporeformer, the above-mentioned acne that all can cause occur, and the secretion of the growth of sebaceous gland and sebum is directly by androgenic domination, under its effect, sebum forms free fatty, and hair follicle stimulating also can cause acne type inflammation.Motherland's medical science is as far back as " Yizong Jinjian surgery heart method gist rosacea caused by lung-wind " cloud: " this card is formed by lung meridian heat in blood, often sends out in face nose, and play broken pimple, shape such as broomcorn millet is considered to be worth doing; red complexion swells and ache, and breaks out white lead thorn, with the passing of time all becomes white scales; shape, as Semen Panici miliacei white scales, should take Qing Fei Yin orally, external application DIANDAO SAN "." General Treatise on the Cause and Symptoms of Diseases " is said: " acne vulgaris person, meaning face has the raw skin ulcer of wind heat gas, and head is as large in rice, and also as paddy is large, white person is also ".The traditional Chinese medical science is thought, ferritic sun heat is contained partially, and adolescence life is vigorous in addition, and nutrient blood is partial heat day by day, and heat in blood is stopped up outward, QI and blood stasis, accumulates resistance skin, and sends out primary disease; Or because of the product of the pungent delicious food of surfeit, lung stomach accumulated heat, follows through upper smoked, blood with heat row, on stop up in breast face.If with the passing of time the state of an illness does not heal, QI and blood stasis, passages through which vital energy circulates loses smooth; Or lung stomach accumulated heat, accumulate puzzled for a long time, the raw expectorant of removing dampness, phlegm and blood stasis is primary disease induced factor.Adopting Chinese medicine to remove acne has effective, few side effects, cheap advantage.
Summary of the invention
For above-mentioned technical problem of the prior art, the invention provides a kind of osteophyte-eliminating ointment and preparation method thereof, described this osteophyte-eliminating ointment and preparation method thereof solves the technical problem of the poor effect of Drug therapy acne of the prior art.
A kind of osteophyte-eliminating ointment of the present invention, comprise Chinese herbal medicine extract, emulsifying agent, stearic acid, mineral oil, polydimethylsiloxane, glycerol, deionized water, EDETATE DISODIUM, essence and antiseptic, crude drug in described Chinese herbal medicine extract comprises Radix Et Rhizoma Rhei, Rhizoma Curculiginis, Rhizoma Imperatae, Flos Magnoliae, Herba Menthae, Mel, Folium Isatidis, Herba Vernoniae Patulae, Flos Campsis, Retinervus Luffae Fructus, Radix Ampelopsis, Radix Sanguisorbae, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Herba Polygoni Avicularis, Semen Torreyae, Folium Viticis Negundo, Radix Glehniae and Rhizoma Phragmitis, and the mass percent of above-mentioned each composition is:
Chinese herbal medicine extracting composition 0.5 ~ 1.5%,
Emulsifying agent 1 ~ 2%,
Stearic acid 1 ~ 2%,
Mineral oil 6 ~ 8%,
Polydimethylsiloxane 2 ~ 3%,
Glycerol 8 ~ 10%,
EDETATE DISODIUM 0.05 ~ 0.1%,
Essence 0.3 ~ 0.6%,
Antiseptic 0.1 ~ 0.3%,
Surplus is deionized water.
Further, in described osteophyte-eliminating ointment, the mass percent of each component is:
Chinese herbal medicine extracting composition 1%,
Emulsifying agent 1.5%,
Stearic acid 1.5%,
Mineral oil 7%,
Polydimethylsiloxane 2.5%,
Glycerol 9%,
EDETATE DISODIUM 0.05%,
Essence 0.5%,
Antiseptic 0.2%,
Surplus is deionized water.
Further, described emulsifying agent is methyl glycol fatty acid ester.
Further, described antiseptic is sodium benzoate.
Further, wherein, in described Chinese herbal medicine extract, the parts by weight of its crude drug are: Radix Et Rhizoma Rhei 20 ~ 30 weight portion, Rhizoma Curculiginis 15 ~ 25 weight portion, Rhizoma Imperatae 10 ~ 20 weight portion, Flos Magnoliae 25 ~ 35 weight portion, Herba Menthae 20 ~ 30 weight portion, Mel 20 ~ 30 weight portion, Folium Isatidis 30 ~ 40 weight portion, Herba Vernoniae Patulae 10 ~ 20 weight portion, Flos Campsis 15 ~ 25 weight portion, Retinervus Luffae Fructus 15 ~ 25 weight portion, Radix Ampelopsis 15 ~ 25 weight portion, Radix Sanguisorbae 10 ~ 20 weight portion, Radix Salviae Miltiorrhizae 20 ~ 30 weight portion, Rhizoma Alismatis 15 ~ 25 weight portion, Herba Polygoni Avicularis 10 ~ 20 weight portion, Semen Torreyae 20 ~ 30 weight portion, Folium Viticis Negundo 10 ~ 20 weight portion, Radix Glehniae 10 ~ 20 weight portion and Rhizoma Phragmitis 10 ~ 20 weight portion.
Further, wherein, in described Chinese herbal medicine extract, the parts by weight of its crude drug are: Radix Et Rhizoma Rhei 25 ~ 30 weight portion, Rhizoma Curculiginis 20 ~ 25 weight portion, Rhizoma Imperatae 15 ~ 20 weight portion, Flos Magnoliae 30 ~ 35 weight portion, Herba Menthae 25 ~ 30 weight portion, Mel 25 ~ 30 weight portion, Folium Isatidis 35 ~ 40 weight portion, Herba Vernoniae Patulae 15 ~ 20 weight portion, Flos Campsis 20 ~ 25 weight portion, Retinervus Luffae Fructus 15 ~ 20 weight portion, Radix Ampelopsis 15 ~ 20 weight portion, Radix Sanguisorbae 10 ~ 15 weight portion, Radix Salviae Miltiorrhizae 20 ~ 25 weight portion, Rhizoma Alismatis 15 ~ 20 weight portion, Herba Polygoni Avicularis 10 ~ 15 weight portion, Semen Torreyae 20 ~ 25 weight portion, Folium Viticis Negundo 10 ~ 15 weight portion, Radix Glehniae 10 ~ 15 weight portion and Rhizoma Phragmitis 10 ~ 15 weight portion.
Present invention also offers the preparation method of above-mentioned osteophyte-eliminating ointment, comprise the steps:
1) each material is taken according to percentage by weight;
2) Chinese herbal medicine extract is prepared;
3) glycerol is dispersed in water, is elevated to 70 ~ 85 DEG C simultaneously, adds EDETATE DISODIUM, obtain first-phase;
4) emulsifying agent, stearic acid, mineral oil and polydimethylsiloxane are mixed, obtain second-phase;
5) join in first-phase by second-phase, stir, froth breaking is cooled to 30 ~ 55 DEG C, adds Chinese herbal medicine extract subsequently, adds essence and antiseptic, and pH value controls, 5.0 ~ 7.0, to add deionized water, and stir discharging, obtains osteophyte-eliminating ointment.
Further, the preparation method of described Chinese herbal medicine extract comprises the steps:
1) Radix Et Rhizoma Rhei, Rhizoma Curculiginis, Rhizoma Imperatae, Flos Magnoliae, Herba Menthae, Mel, Folium Isatidis, Herba Vernoniae Patulae, Flos Campsis, Retinervus Luffae Fructus, Radix Ampelopsis, Radix Sanguisorbae, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Herba Polygoni Avicularis, Semen Torreyae, Folium Viticis Negundo, Radix Glehniae and Rhizoma Phragmitis is taken respectively according to parts by weight;
2) Herba Menthae powder is broken into 80 ~ 120 orders for subsequent use;
3) Radix Et Rhizoma Rhei, Rhizoma Curculiginis, Rhizoma Imperatae, Flos Magnoliae, Folium Isatidis, Herba Vernoniae Patulae, Flos Campsis, Retinervus Luffae Fructus, Radix Ampelopsis, Radix Sanguisorbae, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Herba Polygoni Avicularis, Semen Torreyae, Folium Viticis Negundo, Radix Glehniae and Rhizoma Phragmitis are ground into 30 ~ 50 orders respectively, then add in a reaction vessel and mix, water extraction 3 ~ 5 times, merge extractive liquid, filters, macroporous resin loading, collect eluent, concentrated except desolventizing, vacuum drying, obtain and get dry extract, be ground into 80 ~ 120 orders;
4) by the Herba Menthae powder that second step obtains, the powder that the 3rd step obtains and Mel mix, the medicine for removing acne described in acquisition.
Further, water extraction three times, the water that first time adds mixture quality 2 ~ 4 times in the mixture, extracts 3 ~ 5h; Second time adds the water of first step water extract quality 2 ~ 4 times again, extracts 3 ~ 5h; Second time adds the water of second step water extract quality 2 ~ 4 times again, extracts 0.5 ~ 2h.
Further, adopt D101 macroporous resin loading, collect 30 ~ 80wt% ethanol elution.
In the present invention, Radix Et Rhizoma Rhei is attacked stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, Rhizoma Curculiginis the kidney warming sun, strengthening bone and muscle, Rhizoma Imperatae cooling blood for hemostasis, clearing away heat and promoting diuresis, the pungent perfume of Flos Magnoliae is evacuated, and turn floating and rise, can fall apart wind and heat in the lung meridian, fragrant odour, the kind facial ailment said due to cold or exposure of dispelling of Herba Menthae, have and promote that skin absorbs the merit of the efficacy of a drug, Mel is the elite of all sorts of flowers, heat-clearing and toxic substances removing, convergence granulation promoting, both can nutrition skin care, played adhesive attraction again, Folium Isatidis heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling, and Herba Vernoniae Patulae wind and heat dispersing is inducing diuresis and reducing edema, Flos Campsis promoting the circulation of blood blood stasis dispelling, Retinervus Luffae Fructus dredge the meridian passage, Radix Ampelopsis heat-clearing and toxic substances removing, expelling pus and promoting granulation, Radix Sanguisorbae cooling blood for hemostasis, removing toxic substances sore, Radix Salviae Miltiorrhizae has anti-inflammation, blood circulation promoting and blood stasis dispelling, promote the effects such as wound healing, Rhizoma Alismatis promoting diuresis to eliminate damp pathogen, spleen invigorating invigorating middle warmer stomach function regulating Herba Polygoni Avicularis relieving stranguria by diuresis, killing parasites for relieving itching, Semen Torreyae killing insect and eliminating accumulation, nourishing the lung to arrest cough, Folium Viticis Negundo expelling pathogenic wind from the body surface, dehumidifying, parasite killing, Radix Glehniae nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid, Rhizoma Phragmitis lung heat clearing gastric heat, all medicines share, and play blood circulation promoting regulates qi altogether, wind and heat dispersing, detoxification and promoting urination, dispersing swelling and dissipating binds, detoxification sore treatment, convergence granulation promoting, nourish effect of skin.
Radix Et Rhizoma Rhei: bitter in the mouth, cold in nature, return stomach, large intestine, liver, spleen channel, there is effect of purging heat to relax the bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, cure mainly excess-heat constipation, the accumulation of heat feeling of stuffiness in chest, damp-heat dysentery, jaundice, gonorrhea, edema abdominal distention; dysuria, conjunctival congestion, laryngopharynx swelling and pain, aphtha of the mouth and tongue, gastropyretic vomiting; spit blood, spitting of blood, epistaxis, has blood in stool, hematuria; blood-retention, amenorrhea, the stagnant stomachache of the stasis of blood in puerperal, lump in the abdomen, traumatic injury; pyretic toxicity carbuncle and ulcer, and erysipelas, the cards such as scald, Radix Et Rhizoma Rhei has the effect of broad-spectrum antiseptic.
Rhizoma Curculiginis: acrid in the mouth, warm in nature, return kidney, Liver Channel, there is the kidney warming sun, effect of strengthening bone and muscle, cure mainly sexual impotence cold sperm, urinary incontinence, metrorrhagia, trusted subordinate's cold type of pain, cold arthralgia of loins and legs, carbuncle, scrofula, the cards such as yang deficiency cold diarrhea.
Rhizoma Imperatae: sweet in the mouth, cold in nature, enter lung, stomach, urinary bladder channel, have the effect of cooling blood for hemostasis, clearing away heat and promoting diuresis, be mainly used in haematemesis, hemoptysis that lung stomach has accumulated heat; Damp invasion of lower energizer pents up the hematuria of bladder; Calentura excessive thirst taking fluids profusely; Gastropyretic vomiting; The cards such as jaundice due to damp-heat.
Flos Magnoliae: acrid in the mouth, warm in nature, enter lung, stomach warp, there is effect of expelling wind and cold, understand things pain-stopping, cure mainly headche due to wind-cold, dizzy, nasal sinusitis, nose cold current tears, toothache, the cards such as swelling of the face.
Herba Menthae: acrid in the mouth, cool in nature, enters lung, Liver Channel, has effect of dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, dispersing the stagnated live-QI to relieve the stagnation of QI, for affection due to external wind and heat or epidemic febrile disease from the beginning of, headache due to pathogenic wind-heat, the many tear of Ramulus et Folium Bischofiae Javanicae, laryngopharynx swelling and pain, measles is sent out not smooth thoroughly, and rubella is scratched where it itches, irritability stasis, and uncomfortable in chest not relaxing waits card.
Mel: sweet in the mouth, property is put down, and returns spleen; Stomach; Lung; Large intestine channel, has invigorating middle warmer emergency, nourishing the lung to arrest cough, effect that intestine moistening is dry, for weakness of the spleen and stomach, and the tired few food of body, epigastric pain, or dysentery stomachache; Xeropulmonary cough, the few or dry cough of expectorant; Dryness of the intestine Tianjin is withered, constipation; The cards such as heat-virulence in a sore.
Folium Isatidis: bitter in the mouth, property Great Cold, GUIXIN, liver, gallbladder, stomach warp, have antipyretic and detoxicated, cooling blood and dissolving purpura, effect of jaundice eliminating, can the excess-heat that divides of clearing heat in QI system, and can separate again the pyretic toxicity of blood system, the high febrile perspiration being mainly used in pestilence calentura caused goes out, excessive thirst taking fluids profusely; The speckle that fire-toxin is flourishing is gone mad, the symptoms such as haematemesis; The unconsciousness due to high fever of measles, rash color is purple dark; Dampness-heat in the liver and gallbladder accumulates the jaundice of steaming; The deafness and tinnitus of liver and gall fire liter; The card such as pharyngalgia, aphtha of the mouth and tongue, hepatitis that fire stagnation pyretic toxicity is caused.
Herba Vernoniae Patulae: be the herb of ironweed plant Herba Vernoniae Patulae, bitter in the mouth, pungent, property is put down, and has wind and heat dispersing, dampness removing, effect of detumescence, cures mainly cold, fever, dysentery, headache due to hyperactivity of liver-YANG, hypertension, have loose bowels, rheumatic arthralgia, eczema, urticaria, furuncle, acute mastitis, traumatic injury, ulcerous nonunion, the cards such as manihot poisoning.
Flos Campsis: latin name
campsis Flos, sweet in the mouth, acid, cold in nature, return liver, pericardium channel, there is promoting the circulation of blood blood stasis removing, effect of cooling blood, expelling wind, for Jing Bi WEIJIA, puerperal swelling of the breast, rubella is rubescent, skin pruritus, the cards such as acne.
Retinervus Luffae Fructus: cool in nature, sweet in the mouth.Enter lung, stomach, Liver Channel, there is dredging collateral, invigorate blood circulation, the effect of dispeling the wind, cure mainly the cards such as arthralgia pain contracture, distending pain in the chest and hypochondrium, galactostasis.
Radix Ampelopsis: latin name
ampelopsis Radix, bitter in the mouth, cold nature, GUIXIN, stomach warp, have effect of heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, expelling pus and promoting granulation, cure mainly the cards such as carbuncle carbuncle on the back, furuncle, burn and scald.
Radix Sanguisorbae: bitter in the mouth, acid, puckery, cold nature, enter large intestine, liver, stomach warp, there is cooling blood for hemostasis, the effect of removing toxic substances sore, for caused by heat in blood various go out blood disorder, especially part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels intenseness of heat is applicable to, having blood in stool of the absurd row of forcing blood, dysentery, the bottoms such as metrorrhagia go out blood disorder, Radix Sanguisorbae has good anastalsis, to staphylococcus aureus, beta hemolytic streptococcus, streptococcus pneumoniae etc. have stronger inhibitory action, containing tannin in Radix Sanguisorbae, detumescence hemostasis is had to hindering face, astriction, can reduce and ooze out, promote that new skin grows, Radix Sanguisorbae also has the antibacterial action of wide spectrum, the mode adopting charcoal to fry can prevent its hydrolysis of tannins contained by body absorption, strengthen its antibacterial action.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature, enters the heart, Liver Channel, has promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, and clear away heart-fire relieving restlessness, the effect of nourishing blood to tranquillize the mind, for menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, the cards such as angina pectoris.
Rhizoma Alismatis: sweet in the mouth, light, cold in nature, enters kidney, urinary bladder channel, has promoting diuresis to eliminate damp pathogen, purging heat and treating stranguria, the lung that clears away heart-fire, rushes down the effect of kidney fire, is mainly used in insufficiency of the spleen retention of water-damp, the wet hydrosarca of spreading unchecked of water; The tired resistance of the heresy of diseases caused by retention of fluid phlegm-damp, what cause that clear YANG failing to ascend voiced sound do not fall is dizzy; The dysuria of damp invasion of lower energizer, red short puckery pain, and the card such as jaundice due to damp-heat, have inhibitory action to tubercule bacillus, pneumonia two ball coccus, staphylococcus aureuses etc.
Rhizoma Alismatis: sweet in the mouth, light, cold in nature, enters kidney, urinary bladder channel, has promoting diuresis to eliminate damp pathogen, purging heat and treating stranguria, the lung that clears away heart-fire, rushes down the effect of kidney fire, is mainly used in insufficiency of the spleen retention of water-damp, the wet hydrosarca of spreading unchecked of water; The tired resistance of the heresy of diseases caused by retention of fluid phlegm-damp, what cause that clear YANG failing to ascend voiced sound do not fall is dizzy; The dysuria of damp invasion of lower energizer, red short puckery pain, and the card such as jaundice due to damp-heat.
Herba Polygoni Avicularis: latin name
polygoni Avicularis Herba, bitter in the mouth, cold nature, enters urinary bladder channel, has relieving stranguria by diuresis, effect of killing parasites for relieving itching, and for stranguria, especially sand Stranguria, stranguria caused by urinary stone, dysuria, jaundice due to damp-heat, dysentery, is with inferior card.
Semen Torreyae: latin name
torreyae Semen, sweet in the mouth, property is put down, and return lung, stomach, large intestine channel, have killing insect and eliminating accumulation, nourishing the lung to arrest cough, effect of loosening bowel to relieve constipation, cures mainly ancylostomiasis, ascariasis, abdominal pain due to worm stagnation, infantile malnutrition, and soap is coughed, the cards such as constipation.
Folium Viticis Negundo: latin name
viticis NegundoFolium, acrid in the mouth; Bitter; Property is put down, and returns lung meridian, has removing dampness of inducing sweat, eliminating phlegm and relieving asthma; Removing toxic substances, expelling pathogenic wind from the body surface, dehumidifying, parasite killing, effect of pain relieving, cures mainly Common Cold, cough, asthma; Stomachache; Stomachache; Heat-damp in summer dysentery; Beriberi swelling; Rubella pruritus; Tinea pedis; Acute mastitis swells and ache; The cards such as snake bite and insect sting.
Radix Glehniae: cold nature, sweet in the mouth, micro-hardship, have nourishing YIN and clearing away lung-heat, effect of reinforcing stomach reg fluid, cures mainly the cards such as lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound be thirsty.
Rhizoma Phragmitis: sweet in the mouth, cold in nature, enter lung, stomach warp, have lung heat clearing gastric heat, diuresis, dissipating depression of QI clearing away phlegm, the effect of YIN nourishing and the production of body fluid promoting, it is thirsty to be mainly used in treating the dysphoria with smothery sensation that epidemic febrile disease joins the army point, and dryness of the tongue Tianjin is few; The rash of measles goes out not saturating, and pathogenic heat violates the cough and expectoration of lung; The cough vomiting pus of lung abscess; The damp and hot card such as vomiting singultus blocked in stomach.
The Chinese herbal medicine extracting composition of extraction, is applied in daily cold cream for principle with blood circulation promoting regulates qi, wind and heat dispersing, detoxification and promoting urination, dispersing swelling and dissipating binds, detoxification sore treatment, convergence granulation promoting, nourishing skin by the present invention, obtains a kind of osteophyte-eliminating ointment eliminating acne.
The present invention compares with prior art, and its technological progress is significant.A kind of osteophyte-eliminating ointment for removing acne of the present invention, it is removed acne and has effective, few side effects, and cheap advantage, can remove the virulence factor of acne, has positive effect to the secondary infection for the treatment of corynebacterium acnes.
Detailed description of the invention
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1
The invention provides a kind of osteophyte-eliminating ointment eliminating acne, its raw material comprises Chinese herbal medicine extracting composition, emulsifying agent methyl glycol fatty acid ester, stearic acid, mineral oil, polydimethylsiloxane, glycerol, deionized water, EDETATE DISODIUM, essence and preservative sodium benzoate, in osteophyte-eliminating ointment described in every 100g, the quality of each component is respectively Chinese herbal medicine extracting composition 0.5g ~ 1.5g, emulsifying agent methyl glycol fatty acid ester 1g ~ 2g, stearic acid 1g ~ 2g, mineral oil 6g ~ 8g, polydimethylsiloxane 2g ~ 3g, glycerol 8g ~ 10g, EDETATE DISODIUM 0.05g ~ 0.1g, essence 0.3g ~ 0.6g, preservative sodium benzoate 0.1 g ~ 0.3g, add deionized water to 100g.
Preferably, in osteophyte-eliminating ointment described in every 100g, the quality of each component is respectively Chinese herbal medicine extracting composition 1g, emulsifying agent methyl glycol fatty acid ester 1.5g, stearic acid 1.5g, mineral oil 7g, polydimethylsiloxane 2.5g, glycerol 9g, EDETATE DISODIUM 0.05g, essence 0.5g, preservative sodium benzoate 0.2g, adds deionized water to 100g.
Present invention also offers the preparation method of above-mentioned osteophyte-eliminating ointment, comprising:
The first step, preparation Chinese herbal medicine extracting composition;
Second step, is dispersed in water glycerol, is elevated to 80 DEG C simultaneously, adds EDETATE DISODIUM by weight subsequently, obtains first-phase;
3rd step, mixes emulsifying agent, stearic acid, mineral oil and polydimethylsiloxane according to above-mentioned weight, obtains second-phase;
4th step, joins second-phase in first-phase, stirs, and froth breaking is cooled to 50 DEG C, add the Chinese herbal medicine extracting composition that the first step obtains subsequently, add essence and antiseptic further, add deionized water to 100g, pH value controls 5.0 ~ 7.0, and stir discharging, obtains osteophyte-eliminating ointment.
Further, in described Chinese herbal medicine extract, its crude drug comprises Radix Et Rhizoma Rhei, Rhizoma Curculiginis, Rhizoma Imperatae, Flos Magnoliae, Herba Menthae, Mel, Folium Isatidis, Herba Vernoniae Patulae, Flos Campsis, Retinervus Luffae Fructus, Radix Ampelopsis, Radix Sanguisorbae, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Herba Polygoni Avicularis, Semen Torreyae, Folium Viticis Negundo, Radix Glehniae and Rhizoma Phragmitis, in described crude drug, the parts by weight of each composition are: Radix Et Rhizoma Rhei 20 ~ 30 weight portion, Rhizoma Curculiginis 15 ~ 25 weight portion, Rhizoma Imperatae 10 ~ 20 weight portion, Flos Magnoliae 25 ~ 35 weight portion, Herba Menthae 20 ~ 30 weight portion, Mel 20 ~ 30 weight portion, Folium Isatidis 30 ~ 40 weight portion, Herba Vernoniae Patulae 10 ~ 20 weight portion, Flos Campsis 15 ~ 25 weight portion, Retinervus Luffae Fructus 15 ~ 25 weight portion, Radix Ampelopsis 15 ~ 25 weight portion, Radix Sanguisorbae 10 ~ 20 weight portion, Radix Salviae Miltiorrhizae 20 ~ 30 weight portion, Rhizoma Alismatis 15 ~ 25 weight portion, Herba Polygoni Avicularis 10 ~ 20 weight portion, Semen Torreyae 20 ~ 30 weight portion, Folium Viticis Negundo 10 ~ 20 weight portion, Radix Glehniae 10 ~ 20 weight portion and Rhizoma Phragmitis 10 ~ 20 weight portion.
Further, in described crude drug, the parts by weight of each composition are: Radix Et Rhizoma Rhei 25 ~ 30 weight portion, Rhizoma Curculiginis 20 ~ 25 weight portion, Rhizoma Imperatae 15 ~ 20 weight portion, Flos Magnoliae 30 ~ 35 weight portion, Herba Menthae 25 ~ 30 weight portion, Mel 25 ~ 30 weight portion, Folium Isatidis 35 ~ 40 weight portion, Herba Vernoniae Patulae 15 ~ 20 weight portion, Flos Campsis 20 ~ 25 weight portion, Retinervus Luffae Fructus 15 ~ 20 weight portion, Radix Ampelopsis 15 ~ 20 weight portion, Radix Sanguisorbae 10 ~ 15 weight portion, Radix Salviae Miltiorrhizae 20 ~ 25 weight portion, Rhizoma Alismatis 15 ~ 20 weight portion, Herba Polygoni Avicularis 10 ~ 15 weight portion, Semen Torreyae 20 ~ 25 weight portion, Folium Viticis Negundo 10 ~ 15 weight portion, Radix Glehniae 10 ~ 15 weight portion and Rhizoma Phragmitis 10 ~ 15 weight portion.
Further, in described crude drug, the parts by weight of each composition are: Radix Et Rhizoma Rhei 25 weight portion, Rhizoma Curculiginis 20 weight portion, Rhizoma Imperatae 15 weight portion, Flos Magnoliae 30 weight portion, Herba Menthae 25 weight portion, Mel 25 weight portion, Folium Isatidis 35 weight portion, Herba Vernoniae Patulae 15 weight portion, Flos Campsis 20 weight portion, Retinervus Luffae Fructus 15 weight portion, Radix Ampelopsis 20 weight portion, Radix Sanguisorbae 15 weight portion, Radix Salviae Miltiorrhizae 25 weight portion, Rhizoma Alismatis 20 weight portion, Herba Polygoni Avicularis 15 weight portion, Semen Torreyae 25 weight portion, Folium Viticis Negundo 15 weight portion, Radix Glehniae 15 weight portion and Rhizoma Phragmitis 15 weight portion.
The preparation method of above-mentioned Chinese herbal medicine extract comprises the steps:
1) Radix Et Rhizoma Rhei, Rhizoma Curculiginis, Rhizoma Imperatae, Flos Magnoliae, Herba Menthae, Mel, Folium Isatidis, Herba Vernoniae Patulae, Flos Campsis, Retinervus Luffae Fructus, Radix Ampelopsis, Radix Sanguisorbae, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Herba Polygoni Avicularis, Semen Torreyae, Folium Viticis Negundo, Radix Glehniae and Rhizoma Phragmitis is taken respectively according to parts by weight;
2) Herba Menthae powder is broken into 80 ~ 120 orders for subsequent use;
3) Radix Et Rhizoma Rhei, Rhizoma Curculiginis, Rhizoma Imperatae, Flos Magnoliae, Folium Isatidis, Herba Vernoniae Patulae, Flos Campsis, Retinervus Luffae Fructus, Radix Ampelopsis, Radix Sanguisorbae, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Herba Polygoni Avicularis, Semen Torreyae, Folium Viticis Negundo, Radix Glehniae and Rhizoma Phragmitis are ground into 30 ~ 50 orders respectively, then add in a reaction vessel and mix, water extraction 3 ~ 5 times, merge extractive liquid, filters, macroporous resin loading, collect eluent, concentrated except desolventizing, vacuum drying, obtain and get dry extract, be ground into 80 ~ 120 orders;
4) by the Herba Menthae powder that second step obtains, the powder that the 3rd step obtains and Mel mix, the medicine for removing acne described in acquisition.
Further, water extraction three times, the water that first time adds mixture quality 2 ~ 4 times in the mixture, extracts 3 ~ 5h; Second time adds the water of first step water extract quality 2 ~ 4 times again, extracts 3 ~ 5h; Second time adds the water of second step water extract quality 2 ~ 4 times again, extracts 0.5 ~ 2h.
Further, adopt D101 macroporous resin loading, collect 30 ~ 80wt% ethanol elution.
Embodiment 2 traditional Chinese medicine extraction component 1
Herba Menthae 25g is ground into 100 orders for subsequent use, take Radix Et Rhizoma Rhei 25g, Rhizoma Curculiginis 20g by weight, Rhizoma Imperatae 15g, Flos Magnoliae 30g, Folium Isatidis 35g, Herba Vernoniae Patulae 15g, Flos Campsis 20g, Retinervus Luffae Fructus 15g, Radix Ampelopsis 20g, Radix Sanguisorbae 15g, Radix Salviae Miltiorrhizae 25g, Rhizoma Alismatis 20g, Herba Polygoni Avicularis 15g, Semen Torreyae 25g, Folium Viticis Negundo 15g, Radix Glehniae 15g and Rhizoma Phragmitis 15g be ground into 40 orders respectively, mix, water extraction three times, the water of first time 1kg, extracts 4h; The water of second time 1kg, extracts 3h, the water of third time 1kg, extract 1h, merge extractive liquid, filter, D101 macroporous resin loading, collect 30 ~ 80wt% ethanol elution, concentrated except desolventizing, vacuum drying, obtain and get dry extract, be ground into 100 orders for subsequent use, the Herba Menthae powder obtained above and mixed-powder and Mel 25g are mixed, obtain traditional Chinese medicine extraction component.
Embodiment 3 traditional Chinese medicine extraction component 2
Herba Menthae 30g is ground into 100 orders for subsequent use, take Radix Et Rhizoma Rhei 30g, Rhizoma Curculiginis 25g by weight, Rhizoma Imperatae 20g, Flos Magnoliae 35g, Folium Isatidis 40g, Herba Vernoniae Patulae 20g, Flos Campsis 25g, Retinervus Luffae Fructus 20g, Radix Ampelopsis 20g, Radix Sanguisorbae 15g, Radix Salviae Miltiorrhizae 25g, Rhizoma Alismatis 20g, Herba Polygoni Avicularis 15g, Semen Torreyae 25g, Folium Viticis Negundo 15g, Radix Glehniae 15g and Rhizoma Phragmitis 15g be ground into 40 orders respectively, mix, water extraction three times, the water of first time 1.2kg, extracts 4h; The water of second time 1.2kg, extracts 3h, the water of third time 1.2kg, extract 1h, merge extractive liquid, filter, D101 macroporous resin loading, collect 30 ~ 80wt% ethanol elution, concentrated except desolventizing, vacuum drying, obtain and get dry extract, be ground into 100 orders for subsequent use, the Herba Menthae powder obtained above and mixed-powder and Mel 30g are mixed, obtain traditional Chinese medicine extraction component.
Embodiment 4 traditional Chinese medicine extraction component 3
Herba Menthae 25g is ground into 100 orders for subsequent use, take Radix Et Rhizoma Rhei 25g, Rhizoma Curculiginis 20g by weight, Rhizoma Imperatae 15g, Flos Magnoliae 30g, Folium Isatidis 35g, Herba Vernoniae Patulae 15g, Flos Campsis 20g, Retinervus Luffae Fructus 15g, Radix Ampelopsis 15g, Radix Sanguisorbae 10g, Radix Salviae Miltiorrhizae 20g, Rhizoma Alismatis 15g, Herba Polygoni Avicularis 10g, Semen Torreyae 20g, Folium Viticis Negundo 10g, Radix Glehniae 10g and Rhizoma Phragmitis 10g be ground into 40 orders respectively, mix, water extraction three times, the water of first time 0.9kg, extracts 4h; The water of second time 0.9kg, extracts 3h, the water of third time 0.9kg, extract 1h, merge extractive liquid, filter, D101 macroporous resin loading, collect 30 ~ 80wt% ethanol elution, concentrated except desolventizing, vacuum drying, obtain and get dry extract, be ground into 100 orders for subsequent use, the Herba Menthae powder obtained above and mixed-powder and Mel 25g are mixed, obtain traditional Chinese medicine extraction component.
Embodiment 5 toxicology detects
Acute toxicity test
Animal: Kunming mouse, body weight 21 ~ 24g, male and female half and half.
LD
50calculate: adopt improvement karber's method, mice is divided into 5 groups at random, often organize 10, male and female half and half, traditional Chinese medicine extraction component 1 adding distil water embodiment 1 prepared dissolves, and is made into Cmax, by the administration of mice maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g/kg), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.
Maximum tolerated dose measures (MTD value): get mice 20, each 10 of male and female.Traditional Chinese medicine extraction component 1 adding distil water embodiment 1 prepared dissolves, and is made into maximum concentration, by the maximum tolerated dose of animal, feeds device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in a day (interval half an hour), each 0.5ml (every ml is containing crude drug 0.36g), total dose is 18g crude drug/kgd.Continuous Observation 7 days after administration.
Result of the test
At LD
50in calculating when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kgd), have no dead mouse, namely do not measure LD
50, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death, show that acute toxicity is minimum, MTD > 18g/Kgd.
Aggregate toxicity is tested
Traditional Chinese medicine extraction component 1 adding distil water embodiment 1 prepared dissolves, to mice by 7.69,19.18 and 43.21g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to rat all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after rat long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Embodiment 6 osteophyte-eliminating ointment 1
Glycerol 9g is dispersed in 50g water, be elevated to 80 DEG C simultaneously, add EDETATE DISODIUM 0.05g by weight subsequently, obtain first-phase, by emulsifying agent methyl glycol fatty acid ester 1.5g, stearic acid 1.5g, mineral oil 7g and polydimethylsiloxane 2.5g mixes, obtain second-phase, second-phase is joined in first-phase, stir, froth breaking is cooled to 50 DEG C, add the Chinese herbal medicine extracting composition 1g that embodiment 1 obtains subsequently, add essence 0.5g and preservative sodium benzoate 0.2g further, add deionized water to 100g, pH value controls 5.0 ~ 7.0, stir discharging, obtain osteophyte-eliminating ointment 1.
Embodiment 7 zest detects
By healthy adult white, man exempts from 10, body weight 2.5 ~ 2.7kg, male and female half and half.By its spinal column both sides skin unhairing 3cm × 3cm, osteophyte-eliminating ointment 1 prepared by Example 6, is coated on a plucked skin in rabbit back side, and cover with one deck cellophane, then fixed with nonirritant medical proof fabric and binder, opposite side distilled water compares.Every experimental animal is applied ointment or plaster after 4h, removes tested material, with the skin of warm water cleaning application site, respectively at 1,24,48h observes and records the dermoreaction of application site, the standards of grading specified according to " disinfection technology standard " and classification are marked.Irritation test shows, facial film provided by the invention is 0 to rabbit skin wound repair integration, and skin, without erythema, belongs to non-stimulated.
Embodiment 8 osteophyte-eliminating ointment 2(comparative example)
Glycerol 9g is dispersed in 50g water, be elevated to 80 DEG C simultaneously, add EDETATE DISODIUM 0.05g by weight subsequently, obtain first-phase, emulsifying agent methyl glycol fatty acid ester 1.5g, stearic acid 1.5g, mineral oil 7g and polydimethylsiloxane 2.5g are mixed, obtain second-phase, second-phase is joined in first-phase, stir, froth breaking is cooled to 50 DEG C, adds essence 0.5g and preservative sodium benzoate 0.2g subsequently, add deionized water to 100g, pH value controls 5.0 ~ 7.0, and stir discharging, obtains osteophyte-eliminating ointment 2.
Effect test
Tested object
Tested object is 180 routine acne patients, is divided into treatment group 90 example at random, matched group 90 example.Wherein female 72 example, man 28 example; 14 ~ 35 years old age, average 26 years old; The course of disease is the shortest 6 months, the longest 5 years, average 3 years; Papular acne 70 example, nodulocystic acne 52 example, pustular acne 58 example.2 groups of patient ages, sex, the course of disease, symptom overall scores without significant difference, have comparability through statistical procedures.
Exclusion standard
1, hepatic and kidney function obstacle; 2, Pregnant and lactant women; 3, therapist can not be adhered to or use other method and medicine person.
Therapeutic Method
Treatment group: the osteophyte-eliminating ointment 1 adopting the embodiment of the present invention 5 to prepare spreads upon acne place, clean of elder generation before smearing, with the capable spraying of ultraviolet ion machine, be coated with massage cream massage skin of face, and to corresponding acupuncture point (chengjiang, dicang, cheek car, ShiShimonoseki, in people, Sibai, chengqi, Jingming, the space between the eyebrows, the sun, Zanzhu, te 23 etc.) give the massage, its facial muscle are loosened, be beneficial to drug absorption, with acne needles, ripe acne and blackhead are discharged again, osteophyte-eliminating ointment is spread upon acne place, 30m in washes off, every day is coated with 3-5 time, it within 4 weeks, was 1 course for the treatment of, 1 course for the treatment of added up curative effect.
Matched group: oral minocycline, 0.1g/ time, 2 times/d, smear osteophyte-eliminating ointment 2 prepared by comparative example 1 at acne place, every day is coated with 3-5 time, and 4 weeks was 1 course for the treatment of, and 1 course for the treatment of added up curative effect simultaneously.
Criterion of therapeutical effect
According to " Chinese medical disease Standardization of diagnosis and curative effect " that State Administration of Traditional Chinese Medicine promulgates.Recovery from illness: skin lesion is disappeared, subjective symptoms disappears; Take a turn for the better: subjective symptoms obviously alleviates, and skin lesion disappears more than 30%; Do not heal: all unchanged or skin lesion of skin lesion and symptom disappears less than 30%.
Statistical procedures
Follow-up Data is organized into grade frequency table form, adopts two independent sample non parametric testss (rank test) in statistic software SPSS 13.0 to carry out statistical procedures.
Result
Two groups of effectiveness comparison, the results are shown in Table 1.
Table 1 liang group effectiveness comparison example
By comparing two groups, treatment group comparatively matched group better can eliminate acne, Be very effective, P<0.01, the number of cases comparing 2 groups of recoveries from illness further and take a turn for the better, treatment group skin lesion disappears comparatively fast, general at about 1 week, matched group is comparatively slow, generally in 3-4 week.
Two groups of side effect are compared, and the results are shown in Table 2
Table 2 liang group side effect profile comparative example
By comparison sheet 2, the side effect profile for the treatment of group significantly will be less than matched group, P<0.01.
Recurrence
After 1 course for the treatment of terminates, patient is advised to avoid pungent food greasy thing.Follow up a case by regular visits to after 3 months, treatment group is fully recovered 5 example recurrences in 61 examples, relapse rate 5.49%; Matched group is fully recovered 12 example recurrences in 23 examples, relapse rate 52.2%.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (10)
1. an osteophyte-eliminating ointment, it is characterized in that: comprise Chinese herbal medicine extract, emulsifying agent, stearic acid, mineral oil, polydimethylsiloxane, glycerol, deionized water, EDETATE DISODIUM, essence and antiseptic, crude drug in described Chinese herbal medicine extract comprises Radix Et Rhizoma Rhei, Rhizoma Curculiginis, Rhizoma Imperatae, Flos Magnoliae, Herba Menthae, Mel, Folium Isatidis, Herba Vernoniae Patulae, Flos Campsis, Retinervus Luffae Fructus, Radix Ampelopsis, Radix Sanguisorbae, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Herba Polygoni Avicularis, Semen Torreyae, Folium Viticis Negundo, Radix Glehniae and Rhizoma Phragmitis, and the mass percent of above-mentioned each composition is:
Chinese herbal medicine extracting composition 0.5 ~ 1.5%,
Emulsifying agent 1 ~ 2%,
Stearic acid 1 ~ 2%,
Mineral oil 6 ~ 8%,
Polydimethylsiloxane 2 ~ 3%,
Glycerol 8 ~ 10%,
EDETATE DISODIUM 0.05 ~ 0.1%,
Essence 0.3 ~ 0.6%,
Antiseptic 0.1 ~ 0.3%,
Surplus is deionized water.
2. a kind of osteophyte-eliminating ointment according to claim 1, is characterised in that: in described osteophyte-eliminating ointment, the mass percent of each component is:
Chinese herbal medicine extracting composition 1%,
Emulsifying agent 1.5%,
Stearic acid 1.5%,
Mineral oil 7%,
Polydimethylsiloxane 2.5%,
Glycerol 9%,
EDETATE DISODIUM 0.05%,
Essence 0.5%,
Antiseptic 0.2%,
Surplus is deionized water.
3. a kind of osteophyte-eliminating ointment according to claim 1, is characterised in that: described emulsifying agent is methyl glycol fatty acid ester.
4. a kind of osteophyte-eliminating ointment according to claim 1, is characterised in that: described antiseptic is sodium benzoate.
5. a kind of osteophyte-eliminating ointment according to claim 1, be characterised in that: in described Chinese herbal medicine extract, the parts by weight of its crude drug are: Radix Et Rhizoma Rhei 20 ~ 30 weight portion, Rhizoma Curculiginis 15 ~ 25 weight portion, Rhizoma Imperatae 10 ~ 20 weight portion, Flos Magnoliae 25 ~ 35 weight portion, Herba Menthae 20 ~ 30 weight portion, Mel 20 ~ 30 weight portion, Folium Isatidis 30 ~ 40 weight portion, Herba Vernoniae Patulae 10 ~ 20 weight portion, Flos Campsis 15 ~ 25 weight portion, Retinervus Luffae Fructus 15 ~ 25 weight portion, Radix Ampelopsis 15 ~ 25 weight portion, Radix Sanguisorbae 10 ~ 20 weight portion, Radix Salviae Miltiorrhizae 20 ~ 30 weight portion, Rhizoma Alismatis 15 ~ 25 weight portion, Herba Polygoni Avicularis 10 ~ 20 weight portion, Semen Torreyae 20 ~ 30 weight portion, Folium Viticis Negundo 10 ~ 20 weight portion, Radix Glehniae 10 ~ 20 weight portion and Rhizoma Phragmitis 10 ~ 20 weight portion.
6. a kind of osteophyte-eliminating ointment according to claim 1, be characterised in that: in described Chinese herbal medicine extract, the parts by weight of its crude drug are: Radix Et Rhizoma Rhei 25 ~ 30 weight portion, Rhizoma Curculiginis 20 ~ 25 weight portion, Rhizoma Imperatae 15 ~ 20 weight portion, Flos Magnoliae 30 ~ 35 weight portion, Herba Menthae 25 ~ 30 weight portion, Mel 25 ~ 30 weight portion, Folium Isatidis 35 ~ 40 weight portion, Herba Vernoniae Patulae 15 ~ 20 weight portion, Flos Campsis 20 ~ 25 weight portion, Retinervus Luffae Fructus 15 ~ 20 weight portion, Radix Ampelopsis 15 ~ 20 weight portion, Radix Sanguisorbae 10 ~ 15 weight portion, Radix Salviae Miltiorrhizae 20 ~ 25 weight portion, Rhizoma Alismatis 15 ~ 20 weight portion, Herba Polygoni Avicularis 10 ~ 15 weight portion, Semen Torreyae 20 ~ 25 weight portion, Folium Viticis Negundo 10 ~ 15 weight portion, Radix Glehniae 10 ~ 15 weight portion and Rhizoma Phragmitis 10 ~ 15 weight portion.
7. the preparation method of a kind of osteophyte-eliminating ointment according to claim 1, is characterised in that and comprises the steps:
1) each material is taken according to percentage by weight;
2) Chinese herbal medicine extract is prepared;
3) glycerol is dispersed in water, is elevated to 70 ~ 85 DEG C simultaneously, adds EDETATE DISODIUM, obtain first-phase;
4) emulsifying agent, stearic acid, mineral oil and polydimethylsiloxane are mixed, obtain second-phase;
5) join in first-phase by second-phase, stir, froth breaking is cooled to 30 ~ 55 DEG C, adds Chinese herbal medicine extract subsequently, adds essence and antiseptic, and pH value controls, 5.0 ~ 7.0, to add deionized water, and stir discharging, obtains osteophyte-eliminating ointment.
8. the preparation method of a kind of osteophyte-eliminating ointment according to claim 7, is characterised in that the preparation method of described Chinese herbal medicine extract comprises the steps:
1) Radix Et Rhizoma Rhei, Rhizoma Curculiginis, Rhizoma Imperatae, Flos Magnoliae, Herba Menthae, Mel, Folium Isatidis, Herba Vernoniae Patulae, Flos Campsis, Retinervus Luffae Fructus, Radix Ampelopsis, Radix Sanguisorbae, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Herba Polygoni Avicularis, Semen Torreyae, Folium Viticis Negundo, Radix Glehniae and Rhizoma Phragmitis is taken respectively according to parts by weight;
2) Herba Menthae powder is broken into 80 ~ 120 orders for subsequent use;
3) Radix Et Rhizoma Rhei, Rhizoma Curculiginis, Rhizoma Imperatae, Flos Magnoliae, Folium Isatidis, Herba Vernoniae Patulae, Flos Campsis, Retinervus Luffae Fructus, Radix Ampelopsis, Radix Sanguisorbae, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Herba Polygoni Avicularis, Semen Torreyae, Folium Viticis Negundo, Radix Glehniae and Rhizoma Phragmitis are ground into 30 ~ 50 orders respectively, then add in a reaction vessel and mix, water extraction 3 ~ 5 times, merge extractive liquid, filters, macroporous resin loading, collect eluent, concentrated except desolventizing, vacuum drying, obtain and get dry extract, be ground into 80 ~ 120 orders;
4) by the Herba Menthae powder that second step obtains, the powder that the 3rd step obtains and Mel mix, the medicine for removing acne described in acquisition.
9. the preparation method of a kind of osteophyte-eliminating ointment according to claim 8, is characterised in that: water extraction three times, the water that first time adds mixture quality 2 ~ 4 times in the mixture, extracts 3 ~ 5h; Second time adds the water of first step water extract quality 2 ~ 4 times again, extracts 3 ~ 5h; Second time adds the water of second step water extract quality 2 ~ 4 times again, extracts 0.5 ~ 2h.
10. the preparation method of a kind of osteophyte-eliminating ointment according to claim 8, is characterised in that: adopt D101 macroporous resin loading, collect 30 ~ 80wt% ethanol elution.
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