CN104800629B - A kind of osteophyte-eliminating ointment and preparation method thereof - Google Patents
A kind of osteophyte-eliminating ointment and preparation method thereof Download PDFInfo
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Abstract
A kind of osteophyte-eliminating ointment for eliminating acne of the present invention,Including Chinese herbal medicine extract,Emulsifying agent,Stearic acid,Mineral oil,Dimethyl silicone polymer,Glycerine,Deionized water,EDETATE DISODIUM,Essence and preservative,Bulk pharmaceutical chemicals in Chinese herbal medicine extract include rheum officinale,Thizoma curculiginis,Rhizoma imperatae,The flower bud of lily magnolia,Peppermint,Honey,Folium isatidis,Halfspreading ironweed herb,Chinese trumpet creeper,Luffa,Radix ampelopsis,Garden burnet,Radix Salviae Miltiorrhizae,Rhizoma alismatis,Pivot stores,Chinese torreyanut,Leaf of negundo chastetree,Radix Glehniae and reed root,The mass percent of each composition is Chinese herbal medicine extract component 0.5 ~ 1.5%,Emulsifying agent 1 ~ 2%,Stearic acid 1 ~ 2%,Mineral oil 6 ~ 8%,Dimethyl silicone polymer 2 ~ 3%,Glycerine 8 ~ 10%,EDETATE DISODIUM 0.05 ~ 0.1%,Essence 0.3 ~ 0.6%,Preservative 0.1 ~ 0.3%,Surplus is deionized water.Present invention also offers the preparation method of above-mentioned osteophyte-eliminating ointment.The present invention can remove acne, and effect is good, few side effects.
Description
Technical field
The invention belongs to field of medicaments, more particularly to a kind of osteophyte-eliminating ointment for eliminating acne and preparation method thereof.
Background technology
Acne are a kind of multifactor functionings in caused by pilosebaceous follicle equivalent to the acne vulgaris of modern medicine
Chronic inflammatory skin, is apt to occur in youth of both sexes, is a kind of psychosomatic disease that can not be ignored, severely impacts patient's
Study, work, movement, interpersonal relationships and social life, decline the quality of life of patient.Acne take place mostly in puberty,
Incidence is high, and the cause of disease is complicated.
Modern medicine thinks to be to increase with Serum Testosterone Levels in puberty body, and smegma is vigorous, drainage difficulty etc.
Factor in relation to etc. it is multifactor caused by hair follicle sebum disease, including hair follicle sebum hypersecretion, follicular orifice hyperkeratinization, Cuo
The Propionibacterium propagation of sore, excessive immune response are also related with heredity and psychological factor.The traditional Chinese medical science thinks the disease and lung channel wind
Hot, damp and hot, phlegm-damp accumulation symptom, blood-head, blood stasis etc. are related.
In recent years, developing rapidly with aesthetic medicine, the treatment of acne have significant progress, western medical treatment powder
Thorn mainly reduces the secretion of sebaceous glands, and the venereal disease that diminishes inflammation becomes, and to antiandrogen, prevents tumour from being formed.In recent years report
Minocycline, adapalene gel, Benzamycin gelling agent treatment acne obtain good therapeutic effect, but how much there are erythema, mound
The skin irritation symptom such as rash, scorching hot, furfur, drying.
This disease origin cause of formation, there are bacillus acnes, white element staphylococcus and oval pityriasis Bacillus in pilosebaceous follicle,
It is above-mentioned to cause acne, and the development of sebaceous glands and the secretion of sebum are directly dominated by androgen, under its effect
Sebum forms free fatty, and hair follicle stimulating can also cause acne type inflammation.Motherland's medicine early in《Yizong Jinjian surgery heart method
Gist lung-wind comedo》Cloud:" this card is formed by lung channel blood-head, is often sent out in face nose, plays broken pimple, is considered to be worth doing shaped like broomcorn millet, the red swelling and pain of color,
White powder thorn is broken out, is with the passing of time all considered to be worth doing in vain shaped like milled glutinous broomcorn millet into white bits, preferably takes Qing Fei Yin, external application DIANDAO SAN orally ".《The General Treatise on the Cause and Symptoms of Diseases》Say:
" face sore person, has on meaning face wind-heat gas to give birth to sore, and head such as rice is big, and also as paddy is big, white person is ".The traditional Chinese medical science thinks that ferritic sun heat is partially
Contain, puberty life is vigorous in addition, and increasingly partial heat, blood-head are stopped up outside for ying blood, and qi and blood stasis, accumulates resistance skin, and sends out this disease；Or because of mistake
The product of pungent delicious food are eaten, lung stomach accumulated heat, is followed through upper smoked, and blood is with hot row, and upper heap soil or fertilizer over and around the roots is in chest face.If with the passing of time the state of an illness is not cured, qi and blood stasis,
Passages through which vital energy circulates loses smooth；Or lung stomach accumulated heat, accumulate long it is puzzled, dampness elimination life phlegm, phlegm and blood stasis, is this disease induced factor.Removed using traditional Chinese medicine
Acne are good with effect, few side effects, cheap advantage.
The content of the invention
It is described the present invention provides a kind of osteophyte-eliminating ointment and preparation method thereof for above-mentioned technical problem of the prior art
This osteophyte-eliminating ointment and preparation method thereof solve the ineffective technical problems of drug therapy acne of the prior art.
A kind of osteophyte-eliminating ointment of the present invention, including Chinese herbal medicine extract, emulsifying agent, stearic acid, mineral oil, polydimethylsiloxanes
Alkane, glycerine, deionized water, EDETATE DISODIUM, essence and preservative, the bulk pharmaceutical chemicals in the Chinese herbal medicine extract include rheum officinale,
Thizoma curculiginis, rhizoma imperatae, the flower bud of lily magnolia, peppermint, honey, folium isatidis, halfspreading ironweed herb, Chinese trumpet creeper, luffa, radix ampelopsis, garden burnet, Radix Salviae Miltiorrhizae, rhizoma alismatis, pivots
Storage, Chinese torreyanut, leaf of negundo chastetree, Radix Glehniae and reed root, the mass percent of above-mentioned each composition are：
Chinese herbal medicine extract component 0.5~1.5%,
Emulsifying agent 1~2%,
Stearic acid 1~2%,
Mineral oil 6~8%,
Dimethyl silicone polymer 2~3%,
Glycerine 8~10%,
EDETATE DISODIUM 0.05~0.1%,
Essence 0.3~0.6%,
Preservative 0.1~0.3%,
Surplus is deionized water.
Further, the mass percent of each component is in the osteophyte-eliminating ointment：
Chinese herbal medicine extract component 1%,
Emulsifying agent 1.5%,
Stearic acid 1.5%,
Mineral oil 7%,
Dimethyl silicone polymer 2.5%,
Glycerine 9%,
EDETATE DISODIUM 0.05%,
Essence 0.5%,
Preservative 0.2%,
Surplus is deionized water.
Further, the emulsifying agent is methyl glycol fatty acid ester.
Further, the preservative is sodium benzoate.
Further, wherein, in the Chinese herbal medicine extract, the parts by weight of its bulk pharmaceutical chemicals are：20~30 weight of rheum officinale
Part, 15~25 parts by weight of thizoma curculiginis, 10~20 parts by weight of rhizoma imperatae, 25~35 parts by weight of the flower bud of lily magnolia, 20~30 parts by weight of peppermint, honey
20~30 parts by weight, 30~40 parts by weight of folium isatidis, 10~20 parts by weight of halfspreading ironweed herb, 15~25 parts by weight of Chinese trumpet creeper, luffa
15~25 parts by weight, 15~25 parts by weight of radix ampelopsis, 10~20 parts by weight of garden burnet, 20~30 parts by weight of Radix Salviae Miltiorrhizae, 15~25 weight of rhizoma alismatis
Measure Fen, pivots and store 10~20 parts by weight, 20~30 parts by weight of Chinese torreyanut, 10~20 parts by weight of leaf of negundo chastetree, 10~20 parts by weight of Radix Glehniae
With 10~20 parts by weight of reed root.
Further, wherein, in the Chinese herbal medicine extract, the parts by weight of its bulk pharmaceutical chemicals are：25~30 weight of rheum officinale
Part, 20~25 parts by weight of thizoma curculiginis, 15~20 parts by weight of rhizoma imperatae, 30~35 parts by weight of the flower bud of lily magnolia, 25~30 parts by weight of peppermint, honey
25~30 parts by weight, 35~40 parts by weight of folium isatidis, 15~20 parts by weight of halfspreading ironweed herb, 20~25 parts by weight of Chinese trumpet creeper, luffa
15~20 parts by weight, 15~20 parts by weight of radix ampelopsis, 10~15 parts by weight of garden burnet, 20~25 parts by weight of Radix Salviae Miltiorrhizae, 15~20 weight of rhizoma alismatis
Measure Fen, pivots and store 10~15 parts by weight, 20~25 parts by weight of Chinese torreyanut, 10~15 parts by weight of leaf of negundo chastetree, 10~15 parts by weight of Radix Glehniae
With 10~15 parts by weight of reed root.
Present invention also offers the preparation method of above-mentioned osteophyte-eliminating ointment, include the following steps：
1）Each material is weighed according to percentage by weight；
2）Prepare Chinese herbal medicine extract；
3）Glycerine is dispersed in water, is raised simultaneously to 70 ~ 85 DEG C, adds EDETATE DISODIUM, obtains the first phase；
4）Emulsifying agent, stearic acid, mineral oil and dimethyl silicone polymer are mixed, obtain the second phase；
5）Second is added in the first phase, is stirred evenly, defoaming is cooled to 30 ~ 55 DEG C, then adds Chinese herbal medicine and carries
Take thing, add essence and preservative, pH value control adds deionized water, stirs evenly discharging, acquisition osteophyte-eliminating ointment 5.0~7.0.
Further, the preparation method of the Chinese herbal medicine extract includes the following steps：
1）Weighed respectively according to parts by weight rheum officinale, thizoma curculiginis, rhizoma imperatae, the flower bud of lily magnolia, peppermint, honey, folium isatidis, halfspreading ironweed herb,
Chinese trumpet creeper, luffa, radix ampelopsis, garden burnet, Radix Salviae Miltiorrhizae, rhizoma alismatis, pivots storage, Chinese torreyanut, leaf of negundo chastetree, Radix Glehniae and reed root；
2）It is spare that peppermint is ground into 80 ~ 120 mesh；
3）By rheum officinale, thizoma curculiginis, rhizoma imperatae, the flower bud of lily magnolia, folium isatidis, halfspreading ironweed herb, Chinese trumpet creeper, luffa, radix ampelopsis, garden burnet, Radix Salviae Miltiorrhizae,
Rhizoma alismatis, pivots storage, Chinese torreyanut, leaf of negundo chastetree, Radix Glehniae and reed root are respectively crushed into 30 ~ 50 mesh, then add in a reaction vessel and mix
Closing, water extracts 3 ~ 5 times, and merging extracting solution, filtering, macroreticular resin loading, collects eluent, and concentration removes solvent, is dried in vacuo,
Dry cream is obtained, is ground into 80 ~ 120 mesh；
4）The peppermint powder that second step is obtained, the powder and honey that the 3rd step obtains mix, described in acquisition
Be used for remove the medicines of acne.
Further, water extraction three times, for the first time in the mixture add 2~4 times of mixture quality water, extraction 3 ~
5h；The water of 2~4 times of first step water extract quality is added for the second time, extracts 3 ~ 5h；The extraction of second step water is added for the second time
The water that 2~4 times of amount of substance, extracts 0.5 ~ 2h.
It is further, using D101 macroreticular resin loadings, collect 30~80wt% ethanol eluates.
In the present invention, rheum officinale attacks stagnant, clearing away damp-heat, purging intense heat, cool blood, and thizoma curculiginis warm kidney sun, strengthens the bone, rhizoma imperatae cool blood is stopped
Blood, reducing fever and causing diuresis, the pungent fragrant evacuation of the flower bud of lily magnolia, turn floating and rise, can dissipate wind and heat in the lung meridian, fragrant odour, peppermint is apt to facial ailment said due to cold or exposure of dispelling, there is rush
The work(of the efficacy of a drug is absorbed into skin, honey is the elite of all sorts of flowers, clearing heat and detoxicating, restrains myogenic, not only can nutrition skin care, but also rise viscous
Attached effect, folium isatidis is clearing heat and detoxicating, cool blood detumescence, halfspreading ironweed herb wind and heat dispersing, inducing diuresis and reducing edema, Chinese trumpet creeper promoting circulation of blood dissolving stasis, luffa
Clearing and activating the channels and collaterals, radix ampelopsis is clearing heat and detoxicating, expelling pus and promoting granulation, garden burnet cooling blood and hemostasis, removing toxic substances sore, and Radix Salviae Miltiorrhizae has antibacterial anti-inflammatory, promoting blood circulationization
The stasis of blood, promotes the effect such as wound healing, rhizoma alismatis clearing damp and promoting diuresis, and strengthening spleen and middle warmer and Wei , pivots store promoting diuresis for stranguria, and desinsection is antipruritic, and Chinese torreyanut kills
Worm disperse accumulation, moistens the lung and relieve the cough, and leaf of negundo chastetree expels pathogenic wind from the body surface, dehumidifying, desinsection, Radix Glehniae nourishiing yin to clear away the lung-heat, reinforcing stomach reg fluid, reed root clearing lung-heat stomach
Heat, all medicines share, plays promoting blood circulation qi-regulating, wind and heat dispersing, detoxification and promoting urination, dispersing swelling and dissipating binds, detoxification sore treatment, convergence myogenic, nourishing flesh altogether
The effect of skin.
Rheum officinale：Bitter, it is cold in nature, return stomach, large intestine, liver, the spleen channel, there is purgating heat and bowels, removing pattogenic heat from the blood and toxic material from the body, the work(of dispelling stasis of blood and stimulating the menstrual flow
Effect, cures mainly real heat constipation, the thermojunction feeling of stuffiness in chest, damp-heat dysentery, jaundice, gonorrhoea, and oedema abdomen is expired, difficult urination, hot eyes, abscess of throat,
Aphthae, gastropyretic vomiting, spits blood, and spitting of blood, bleeding from five sense organs or subcutaneous tissue, has blood in stool, hematuria, stores blood, Amenorrhea, postpartum stasis of blood, a lump in the abdomen causing distension and pain, falls
Beating card, the rheum officinales such as damage, heat toxin large carbuncle, erysipelas, scald has the function that broad-spectrum antiseptic.
Thizoma curculiginis：Acrid flavour, it is warm-natured, return kidney, Liver Channel, there is warm kidney sun, the effect of strengthening the bone, cure mainly impotence cold sperm, urine is lost
Prohibit, uterine bleeding, trusted subordinate's crymodynia, cold arthralgia of loins and legs, ulcer, scrofula, the deficiency of yang is cold the card such as to rush down.
Rhizoma imperatae：It is sweet in flavor, it is cold in nature, enter lung, stomach, bladder warp, play the role of cooling blood and hemostasis, reducing fever and causing diuresis, be mainly used for lung
Stomach has the haematemesis of accumulated heat, hemoptysis；Damp invasion of lower energizer pents up the hematuria of bladder；Pyreticosis polydipsia draws drink；Gastropyretic vomiting；Jaundice with damp-heat pathogen etc.
Card.
The flower bud of lily magnolia：Acrid flavour, it is warm-natured, enter lung, stomach, there is the effect of expelling wind and clearing away cold, sensible analgesic, cure mainly anemofrigid headache, mesh
It is dizzy, nasosinusitis, nose cold current tears, dentalgia, the card such as edema of the face.
Peppermint：It is acrid flavour, cool in nature, enter lung, Liver Channel, has dispelling wind and heat from the body, head clearing, relieving sore-throat promoting eruption, the work(of soothing liver-qi stagnation
Effect, for affection of exogenous wind-heat or warm disease from the beginning of, headache due to pathogenic wind-heat, the red more tears of wood, abscess of throat, measles without adequate eruption, rubella itching, liver
The obstruction of the circulation of vital energy is stagnant, and uncomfortable in chest do not relax waits card.
Honey：It is sweet in flavor, mild-natured, returns spleen；Stomach；Lung；The effect of large intestine channel, has bowl spares emergency, moistens the lung and relieve the cough, and ease constipation is dry,
For weakness of the spleen and the stomach, the tired few food of body, epigastric pain, or diarrhea dysentery abdominal pain；Xeropulmonary cough, phlegm is few or dry cough；Intestinal dryness Tianjin is withered, big constipation
Knot；Heat-virulence in a sore etc. is demonstrate,proved.
Folium isatidis：Bitter, property Great Cold, the thoughts of returning home, liver, courage, stomach, have the effect of antipyretic and detoxicated, cooling blood and dissolving purpura, removing jaundice,
The real heat of qi leel and the heat toxin of blood system can be solved clearly, the high fever sweating being mainly used for caused by seasonal febrile diseases pyreticosis, polydipsia draws drink；Fire
The flourishing hair spot of poison is gone mad, the symptom such as haematemesis；The unconsciousness due to high fever of measles, rash color are purple dark；Liver and gallbladder damp-heat accumulates the jaundice of steaming；Liver and gall fire
The deafness and tinnitus of liter；The cards such as pharyngalgia, aphthae, hepatitis caused by the hot and suffocating poison of fire.
Halfspreading ironweed herb：It is bitter, pungent for the herb of ironweed plant halfspreading ironweed herb, it is mild-natured, there is wind and heat dispersing, dampness removing,
The effect of detumescence, cure mainly cold, fever, dysentery, the liver-yang headache, high blood pressure, diarrhea, arthralgia pain due to rheumatism, eczema, nettle rash, sore
Furuncle, acute mastitis, traumatic injury, ulcerous nonunion, manihot poisoning etc. are demonstrate,proved.
Chinese trumpet creeper：Latin nameCampsis Flos, sweet in flavor, sour, cold in nature, Return liver, pericardium channel, have promoting circulation of blood stasis eliminatings, cool blood
The effect of wind-dispelling, for Jing Bi wei lumps in the abdomen, postpartum breast is swollen, and rubella is rubescent, pruitus, the card such as acne.
Luffa：It is cool in nature, it is sweet in flavor.Enter lung, stomach, Liver Channel, there is dredging collateral, invigorate blood circulation, the effect of wind-dispelling, cure mainly numbness pain contraction,
Distending pain in the chest and hypochondrium, alactation etc. are demonstrate,proved.
Radix ampelopsis：Latin nameAmpelopsis Radix, bitter, cold nature, the thoughts of returning home, stomach, there is the clearing heat and detoxicating, carbuncle that disappears to dissipate
The effect of knot, expelling pus and promoting granulation, cure mainly the card such as ulcer carbuncle on the back, furunculosis, burn and scald.
Garden burnet：Bitter, acid, puckery, cold nature, enter large intestine, liver, stomach, have cooling blood and hemostasis, the effect of removing toxic substances sore, is used for
Caused by blood-head it is various go out blood trouble, especially suitable for lower burnt excess heat, compel the lower part such as the having blood in stool of the absurd row of blood, bloody flux, metrorrhagia and go out blood trouble, garden burnet
There is preferable anastalsis, there is stronger suppression to make to staphylococcus aureus, beta hemolytic streptococcus, pneumococcus etc.
With containing tannin in garden burnet, have detumescence hemostasis, astriction to hindering face, can reduce exudation, promote the growth of new skin, garden burnet also has
There is the antibacterial action of wide spectrum, by the way of charcoal stir-fry its hydrolysis of tannins contained can be prevented to be absorbed by the body, strengthen its antibacterial work
With.
Radix Salviae Miltiorrhizae：Bitter, cold nature, enters the heart, Liver Channel, has promoting blood circulation for regulating menstruation, stasis-dispelling and pain-killing, cool blood to disappear carbuncle, relieving restlessness that clears away heart-fire, is supported
The effect of blood and tranquilizing mind, for irregular menstruation, closed dysmenorrhea, a lump in the abdomen causing distension and pain, chest and abdomen shouting pain, hot numbness pain, and sore swell and ache curative is vexed
Egersis；Hepatosplenomegaly, angina pectoris etc. are demonstrate,proved.
Rhizoma alismatis：It is sweet in flavor, light, it is cold in nature, enter kidney, bladder warp, there is clearing damp and promoting diuresis, purging heat and treating stranguria, the lung that clears away heart-fire, the work for rushing down kidney fire
With being mainly used for the wet anasarca spread unchecked of insufficiency of the spleen retention of water-damp, water；The tired resistance of heresy of water drink phlegm wet, causes lucid yang failing to raise voiced sound not
The dizziness of drop；The difficult urination of damp invasion of lower energizer, red short puckery pain, and the card such as jaundice with damp-heat pathogen, to tubercle bacillus, the double ball balls of pneumonia
Bacterium, staphylococcus aureus etc. have inhibitory action.
Rhizoma alismatis：It is sweet in flavor, light, it is cold in nature, enter kidney, bladder warp, there is clearing damp and promoting diuresis, purging heat and treating stranguria, the lung that clears away heart-fire, the work for rushing down kidney fire
With being mainly used for the wet anasarca spread unchecked of insufficiency of the spleen retention of water-damp, water；The tired resistance of heresy of water drink phlegm wet, causes lucid yang failing to raise voiced sound not
The dizziness of drop；The difficult urination of damp invasion of lower energizer, red short puckery pain, and the card such as jaundice with damp-heat pathogen.
Pivot stores：Latin namePolygoni Avicularis Herba, bitter, cold nature, enters bladder warp, leads to Li Shui
The effect of leaching, desinsection is antipruritic, drench, urolithiasis, difficult urination, jaundice with damp-heat pathogen, rush down dysentery, with inferior card for stranguria, especially sand.
Chinese torreyanut：Latin nameTorreyae Semen, sweet in flavor, mild-natured, return lung, stomach, large intestine channel, have killing insect and eliminating accumulation, moistening lung
Cough-relieving, the effect of relaxing bowel, cures mainly hookworm disease, roundworm disease, abdominal pain due to enterositosis, infantile malnutrition, soap cough, constipation etc.
Card.
Leaf of negundo chastetree：Latin nameViticis NegundoFolium, acrid flavour；It is bitter；It is mild-natured, it is distributed in lung channel, there is inducing diaphoresis dampness elimination,
Eliminating phlegm and relieving asthma；The effect of removing toxic substances, expels pathogenic wind from the body surface, and dehumidifies, desinsection, analgesic, cures mainly cold, cough, asthma；Stomachache；Abdominal pain；
Summer-heat and damp rush down dysentery；Tinea pedis swelling；Rubella itch；The ringworm of the foot；Acute mastitis swells and ache；Snakebite and bugbite etc. are demonstrate,proved.
Radix Glehniae：Cold nature, sweet in flavor, slight bitter, has the effect of nourishiing yin to clear away the lung-heat, reinforcing stomach reg fluid, cures mainly lung-heat type cough, overstrain cough
Phlegm blood, pyreticosis injury thirst etc. are demonstrate,proved.
Reed root：It is sweet in flavor, it is cold in nature, enter lung, stomach, there is a clearing lung-heat stomach energy, Yu Di phlegm is opened in diuresis, the effect of nourishing Yin and promoting production of body fluid, mainly
The dysphoria and thirsty joined the army point for treating warm heat disease, the dry Tianjin of tongue are few；The rash of measles goes out impermeable, the cough and expectoration of heat evil criminal's lung；Lung
The cough pyemesis of carbuncle；Damp and hot retardance is demonstrate,proved in vomiting hiccup of stomach etc..
The present invention is with promoting blood circulation qi-regulating, wind and heat dispersing, detoxification and promoting urination, dispersing swelling and dissipating binds, detoxification sore treatment, convergence myogenic, nourishing flesh
Skin is principle, and the Chinese herbal medicine extract component of extraction is applied in daily cold cream, obtains a kind of osteophyte-eliminating ointment for eliminating acne.
The present invention is compared with prior art, its technological progress is significant.A kind of thorn that disappears for being used to remove acne of the present invention
Cream, its removal acne is good with effect, few side effects, cheap advantage, the virulence factor of acne can be removed, to treatment
Corynebacterium acne scabies secondary infection has the function that positive.
Embodiment
Below using embodiment come the embodiment that the present invention will be described in detail, whereby to the present invention how application technology means
To solve technical problem, and that reaches technique effect realizes that process can fully understand and implement according to this.
Embodiment 1
The present invention provides a kind of osteophyte-eliminating ointment for eliminating acne, its raw material includes Chinese herbal medicine extract component, emulsifying agent the third two
Alcohol fatty acid ester, stearic acid, mineral oil, dimethyl silicone polymer, glycerine, deionized water, EDETATE DISODIUM, essence and preservative
Sodium benzoate, often in osteophyte-eliminating ointment described in 100g, the quality of each component is respectively Chinese herbal medicine extract component 0.5g~1.5g, emulsifying agent
Methyl glycol fatty acid ester 1g~2g, stearic acid 1g~2g, mineral oil 6g~8g, dimethyl silicone polymer 2g~3g, glycerine 8g~
10g, EDETATE DISODIUM 0.05g~0.1g, essence 0.3g~0.6g, 0.1 g of preservative sodium benzoate~0.3g, add deionized water
To 100g.
Preferably, in osteophyte-eliminating ointment described in every 100g, the quality of each component is respectively Chinese herbal medicine extract component 1g, emulsifying agent third
Diol fatty acid ester 1.5g, stearic acid 1.5g, mineral oil 7g, dimethyl silicone polymer 2.5g, glycerine 9g, EDETATE DISODIUM
0.05g, essence 0.5g, preservative sodium benzoate 0.2g, add deionized water to 100g.
Present invention also offers the preparation method of above-mentioned osteophyte-eliminating ointment, including：
The first step, prepares Chinese herbal medicine extract component；
Second step, glycerine is dispersed in water, and is raised simultaneously to 80 DEG C, is then added EDETATE DISODIUM by weight, is obtained
First phase；
3rd step, emulsifying agent, stearic acid, mineral oil and dimethyl silicone polymer are mixed according to above-mentioned weight,
Obtain the second phase；
4th step, second is added in the first phase, is stirred evenly, and defoaming is cooled to 50 DEG C, then adds the first step
The Chinese herbal medicine extract component of acquisition, further adds essence and preservative, adds deionized water to 100g, pH value control 5.0~
7.0, discharging is stirred evenly, obtains osteophyte-eliminating ointment.
Further, in the Chinese herbal medicine extract, its bulk pharmaceutical chemicals include rheum officinale, thizoma curculiginis, rhizoma imperatae, the flower bud of lily magnolia, peppermint,
Honey, folium isatidis, halfspreading ironweed herb, Chinese trumpet creeper, luffa, radix ampelopsis, garden burnet, Radix Salviae Miltiorrhizae, rhizoma alismatis, pivots storage, Chinese torreyanut, leaf of negundo chastetree, Radix Glehniae
And reed root, in the bulk pharmaceutical chemicals, the parts by weight of each composition are：20~30 parts by weight of rheum officinale, 15~25 parts by weight of thizoma curculiginis,
10~20 parts by weight of rhizoma imperatae, 25~35 parts by weight of the flower bud of lily magnolia, 20~30 parts by weight of peppermint, 20~30 parts by weight of honey, folium isatidis
30~40 parts by weight, 10~20 parts by weight of halfspreading ironweed herb, 15~25 parts by weight of Chinese trumpet creeper, 15~25 parts by weight of luffa, radix ampelopsis 15
~25 parts by weight, 10~20 parts by weight of garden burnet, 20~30 parts by weight of Radix Salviae Miltiorrhizae, 15~25 parts by weight, pivots of rhizoma alismatis store 10~20 weight
Part, 20~30 parts by weight of Chinese torreyanut, 10~20 parts by weight of 10~20 parts by weight of leaf of negundo chastetree, 10~20 parts by weight of Radix Glehniae and reed root.
Further, the parts by weight of each composition are in the bulk pharmaceutical chemicals：25~30 parts by weight of rheum officinale, thizoma curculiginis 20~
25 parts by weight, 15~20 parts by weight of rhizoma imperatae, 30~35 parts by weight of the flower bud of lily magnolia, 25~30 parts by weight of peppermint, 25~30 weight of honey
Part, 35~40 parts by weight of folium isatidis, 15~20 parts by weight of halfspreading ironweed herb, 20~25 parts by weight of Chinese trumpet creeper, 15~20 weight of luffa
Part, 15~20 parts by weight of radix ampelopsis, 10~15 parts by weight of garden burnet, 20~25 parts by weight of Radix Salviae Miltiorrhizae, 15~20 parts by weight, pivots of rhizoma alismatis store 10
~15 parts by weight, 20~25 parts by weight of Chinese torreyanut, 10~15 parts by weight of leaf of negundo chastetree, 10~15 parts by weight of Radix Glehniae and reed root 10~15
Parts by weight.
Further, the parts by weight of each composition are in the bulk pharmaceutical chemicals：25 parts by weight of rheum officinale, 20 weight of thizoma curculiginis
Part, 15 parts by weight of rhizoma imperatae, 30 parts by weight of the flower bud of lily magnolia, 25 parts by weight of peppermint, 25 parts by weight of honey, 35 parts by weight of folium isatidis, salty shrimp
Spend 15 parts by weight, 20 parts by weight of Chinese trumpet creeper, 15 parts by weight of luffa, 20 parts by weight of radix ampelopsis, 15 parts by weight of garden burnet, 25 weight of Radix Salviae Miltiorrhizae
Part, 20 parts by weight, pivots of rhizoma alismatis store 15 parts by weight, 25 parts by weight of Chinese torreyanut, 15 parts by weight of leaf of negundo chastetree, 15 parts by weight of Radix Glehniae and reed root
15 parts by weight.
The preparation method of above-mentioned Chinese herbal medicine extract includes the following steps：
1）Weighed respectively according to parts by weight rheum officinale, thizoma curculiginis, rhizoma imperatae, the flower bud of lily magnolia, peppermint, honey, folium isatidis, halfspreading ironweed herb,
Chinese trumpet creeper, luffa, radix ampelopsis, garden burnet, Radix Salviae Miltiorrhizae, rhizoma alismatis, pivots storage, Chinese torreyanut, leaf of negundo chastetree, Radix Glehniae and reed root；
2）It is spare that peppermint is ground into 80 ~ 120 mesh；
3）By rheum officinale, thizoma curculiginis, rhizoma imperatae, the flower bud of lily magnolia, folium isatidis, halfspreading ironweed herb, Chinese trumpet creeper, luffa, radix ampelopsis, garden burnet, Radix Salviae Miltiorrhizae,
Rhizoma alismatis, pivots storage, Chinese torreyanut, leaf of negundo chastetree, Radix Glehniae and reed root are respectively crushed into 30 ~ 50 mesh, then add in a reaction vessel and mix
Closing, water extracts 3 ~ 5 times, and merging extracting solution, filtering, macroreticular resin loading, collects eluent, and concentration removes solvent, is dried in vacuo,
Dry cream is obtained, is ground into 80 ~ 120 mesh；
4）The peppermint powder that second step is obtained, the powder and honey that the 3rd step obtains mix, described in acquisition
Be used for remove the medicines of acne.
Further, water extraction three times, for the first time in the mixture add 2~4 times of mixture quality water, extraction 3 ~
5h；The water of 2~4 times of first step water extract quality is added for the second time, extracts 3 ~ 5h；The extraction of second step water is added for the second time
The water that 2~4 times of amount of substance, extracts 0.5 ~ 2h.
It is further, using D101 macroreticular resin loadings, collect 30~80wt% ethanol eluates.
2 traditional Chinese medicine extraction component 1 of embodiment
It is spare that peppermint 25g is ground into 100 mesh, weigh by weight rheum officinale 25g, thizoma curculiginis 20g, rhizoma imperatae 15g, flower bud of lily magnolia 30g,
Folium isatidis 35g, halfspreading ironweed herb 15g, Chinese trumpet creeper 20g, luffa 15g, radix ampelopsis 20g, garden burnet 15g, Radix Salviae Miltiorrhizae 25g, rhizoma alismatis 20g, pivots store
15g, Chinese torreyanut 25g, leaf of negundo chastetree 15g, Radix Glehniae 15g and reed root 15g are respectively crushed into 40 mesh, mix, and water extracts three times,
The water of first time 1kg, extracts 4h；Second of the water for using 1kg, extracts 3h, for the third time with the water of 1kg, extracts 1h, merges extraction
Liquid, filtering, D101 macroreticular resin loadings, collect 30~80wt% ethanol eluates, and concentration removes solvent, is dried in vacuo, and obtains
Dry cream, is ground into that 100 mesh are spare, and previously obtained peppermint powder and mixed-powder and honey 25g are mixed, and obtains
Traditional Chinese medicine extraction component.
3 traditional Chinese medicine extraction component 2 of embodiment
It is spare that peppermint 30g is ground into 100 mesh, weigh by weight rheum officinale 30g, thizoma curculiginis 25g, rhizoma imperatae 20g, flower bud of lily magnolia 35g,
Folium isatidis 40g, halfspreading ironweed herb 20g, Chinese trumpet creeper 25g, luffa 20g, radix ampelopsis 20g, garden burnet 15g, Radix Salviae Miltiorrhizae 25g, rhizoma alismatis 20g, pivots store
15g, Chinese torreyanut 25g, leaf of negundo chastetree 15g, Radix Glehniae 15g and reed root 15g are respectively crushed into 40 mesh, mix, and water extracts three times,
The water of first time 1.2kg, extracts 4h；Second of the water for using 1.2kg, extracts 3h, for the third time with the water of 1.2kg, extracts 1h, merges
Extracting solution, filtering, D101 macroreticular resin loadings, collect 30~80wt% ethanol eluates, and concentration removes solvent, is dried in vacuo,
Dry cream is obtained, is ground into that 100 mesh are spare, previously obtained peppermint powder and mixed-powder and honey 30g are mixed,
Obtain traditional Chinese medicine extraction component.
4 traditional Chinese medicine extraction component 3 of embodiment
It is spare that peppermint 25g is ground into 100 mesh, weigh by weight rheum officinale 25g, thizoma curculiginis 20g, rhizoma imperatae 15g, flower bud of lily magnolia 30g,
Folium isatidis 35g, halfspreading ironweed herb 15g, Chinese trumpet creeper 20g, luffa 15g, radix ampelopsis 15g, garden burnet 10g, Radix Salviae Miltiorrhizae 20g, rhizoma alismatis 15g, pivots store
10g, Chinese torreyanut 20g, leaf of negundo chastetree 10g, Radix Glehniae 10g and reed root 10g are respectively crushed into 40 mesh, mix, and water extracts three times,
The water of first time 0.9kg, extracts 4h；Second of the water for using 0.9kg, extracts 3h, for the third time with the water of 0.9kg, extracts 1h, merges
Extracting solution, filtering, D101 macroreticular resin loadings, collect 30~80wt% ethanol eluates, and concentration removes solvent, is dried in vacuo,
Dry cream is obtained, is ground into that 100 mesh are spare, previously obtained peppermint powder and mixed-powder and honey 25g are mixed,
Obtain traditional Chinese medicine extraction component.
5 toxicology of embodiment detects
Acute toxicity test
Animal：Kunming mouse, 21 ~ 24g of weight, half male and half female.
LD50Calculate：Using improvement karber's method, mouse is randomly divided into 5 groups, every group 10, half male and half female, by embodiment 1
Traditional Chinese medicine extraction component 1 plus the distilled water dissolving of preparation, are made into Cmax, are administered by the maximum allowable capacity of mouse, give dosage
Be followed successively by 18,14.4,11.5,9.2,7.4 (g/kg) by crude drug amount, when animal fasting (can't help water) 18 is small after, in one day point
Administration twice (interval half an hour), each 0.5ml, observes animal dead situation.
Maximum tolerated dose measures (MTD values)：Take mouse 20, each 10 of male and female.Traditional Chinese medicine extraction prepared by embodiment 1
Component 1 plus distilled water dissolving, are made into maximum concentration, and by the maximal tolerance dose of animal, injection of being subject to, which feeds device, to twitch.Dynamic
After when thing fasting (can't help water) 18 is small, administration (interval half an hour), each 0.5ml (contain crude drug per ml at twice in one day
0.36g), total dose is 18g crude drugs/kgd.Continuous observation 7 days after administration.
Result of the test
In LD50In calculating when giving mouse with maximum acceptable concentration and maximum allowable capacity (18g/Kgd), have no
Dead mouse, i.e., do not measure LD50, maximum tolerated dose is only sought, in 7 day observation period, animal its appetite, activity, hair color, essence
Refreshing state etc. is all normal, and development is normal, there are no death, shows that acute toxicity is minimum, MTD ＞ 18g/Kgd.
Aggregate toxicity is tested
Traditional Chinese medicine extraction component 1 plus distilled water dissolving prepared by embodiment 1, mouse is given birth to by 7.69,19.18 and 43.21g
Medicine/kg continuous uses 15 weeks (1.0ml/100g weight, 2 times a day) and be discontinued 3 weeks after, the results showed that：Chinese medicine preparation of the present invention
To indexs such as the hair of rat, behavior, stool and urine, weight, organ weights, blood picture, hepatic and renal function, blood glucose, blood fat without obvious
Influence, internal organs naked eyes are without finding that abnormal change and histological indications show, after medication 15 weeks and drug withdrawal 3 weeks, rat is each
Internal organs nothing is substantially change.Illustrate Chinese medicine preparation of the present invention to small toxicity after rat long-term administration, also without abnormal anti-after drug withdrawal
Should, using safety.
6 osteophyte-eliminating ointment 1 of embodiment
Glycerine 9g is dispersed in 50g water, is raised simultaneously to 80 DEG C, EDETATE DISODIUM 0.05g is then added by weight, obtains
The first phase is obtained, emulsifying agent methyl glycol fatty acid ester 1.5g, stearic acid 1.5g, mineral oil 7g and dimethyl silicone polymer 2.5g are mixed
It is combined, obtains the second phase, second is added in the first phase, is stirred evenly, defoaming is cooled to 50 DEG C, then adds real
The Chinese herbal medicine extract component 1g of the acquisition of example 2 is applied, essence 0.5g and preservative sodium benzoate 0.2g is further added, adds deionized water
To 100g, pH value control stirs evenly discharging, acquisition osteophyte-eliminating ointment 1 5.0~7.0.
7 irritation of embodiment detects
Exempt from 10,2.5~2.7kg of weight with healthy adult white man, half male and half female.By its backbone both sides skin unhairing
3cm × 3cm, osteophyte-eliminating ointment 1 prepared by Example 6, coated on the plucked skin in family's rabbit back side, is covered with one layer of glassine paper
Lid, then fixed with nonirritant medical proof fabric and bandage, opposite side is compared with distilled water.Every experimental animal application
After 4h, tested material is removed, the skin of application site is cleaned with warm water, is observed respectively at 1,24,48h and records the skin of application site
Skin reacts, according to《Disinfection technology standard》Defined standards of grading and classification are scored.Skin irritation test shows, this
It is 0 to rabbit skin wound repair integration to invent the facial mask provided, and skin belongs to non-stimulated without erythema.
8 osteophyte-eliminating ointment 2 of embodiment（Comparative example）
Glycerine 9g is dispersed in 50g water, is raised simultaneously to 80 DEG C, EDETATE DISODIUM 0.05g is then added by weight, obtains
The first phase is obtained, emulsifying agent methyl glycol fatty acid ester 1.5g, stearic acid 1.5g, mineral oil 7g and dimethyl silicone polymer 2.5g are mixed
It is combined, obtains the second phase, second is added in the first phase, is stirred evenly, defoaming is cooled to 50 DEG C, then adds fragrant
Smart 0.5g and preservative sodium benzoate 0.2g, adds deionized water to 100g, and pH value control stirs evenly discharging 5.0~7.0,
Obtain osteophyte-eliminating ointment 2.
Effect test
Test object
Test object is 180 acne patients, is randomly divided into treatment group 90, control group 90.Wherein female 72, man 28
Example；It is 14~35 years old age, 26 years old average；The course of disease is most 6 months short, most 5 years long, 3 years average；Papular acne 70, tubercle capsule
Swollen property acne 52, pustular acne 58.2 groups of patient ages, gender, the course of disease, symptom overall score are statistically analyzed without aobvious
Difference is write, is comparable.
Exclusion standard
1st, hepatic and kidney function obstacle；2nd, Pregnant and lactant women；3rd, it cannot adhere to curer or use other methods and medicine
Thing person.
Treatment method
Treatment group：The osteophyte-eliminating ointment 1 prepared using the embodiment of the present invention 6 is applied at acne, first face cleaning before smearing, with purple
Outside line ion machine row spray, apply massage cream massage skin of face, and to corresponding acupuncture point (in chengjiang, dicang, cheek car, ShiShimonoseki, people,
Sibai, chengqi, Jingming, the space between the eyebrows, the sun, Zanzhu, Sizhukong etc.) give the massage, loosen its facial muscles, so that medicine is inhaled
Receive, then discharged ripe acne and blackhead with acne needles, osteophyte-eliminating ointment is applied at acne, 30m in are washed off, daily to apply
3-5 times, 4 weeks are 1 course for the treatment of, and 1 course for the treatment of counts curative effect.
Control group：Oral minocycline, 0.1g/ times, 2 times/d, while osteophyte-eliminating ointment prepared by comparative example 1 is smeared at acne
2, daily to apply 3-5 times, 4 weeks are 1 course for the treatment of, and 1 course for the treatment of counts curative effect.
Criterion of therapeutical effect
Promulgated according to State Administration of Traditional Chinese Medicine《Chinese medical disease Standardization of diagnosis and curative effect》.Recovery from illness:Skin lesion is disappeared, from
Feel that symptom disappears；Improve：Subjective symptoms substantially mitigates, skin lesion regression more than 30%；It is not cured：Skin lesion and symptom is unchanged or skin
Damage disappears less than 30%.
Statistical procedures
Follow-up Data is organized into grade frequency sheet form, using the non-ginseng of two independent samples in statistic software SPSS 13.0
Number examines (rank sum test) to carry out statistical procedures.
As a result
Two groups of effects compare, and the results are shown in Table 1.
1 two groups of effect comparative examples of table
| Group | Number of cases | Cure | Improve | It is not cured | Total effective rate (%) |
| Treatment group | 90 | 61 | 21 | 8 | 91.1 |
| Control group | 90 | 23 | 41 | 26 | 71.1 |
By comparing two groups, treatment group can preferably eliminate acne, significant effect, P compared with control group<0.01, further
Compare the number of cases of 2 groups of recoveries from illness and improvement, treatment group's skin lesion is disappeared comparatively fast, and generally at 1 week or so, control group is slower, generally in 3-4
Week.
Two groups of side effects are compared, and the results are shown in Table 2
2 two groups of side effect profile comparative examples of table
| Group | Number of cases | Dry | Dry lip | Skin of face is dried | Nausea |
| Treatment group | 90 | 3 | 5 | 0 | 0 |
| Control group | 90 | 46 | 52 | 72 | 29 |
By comparison sheet 2, the side effect profile for the treatment of group is significantly smaller than control group, P<0.01.
Recurrence
After 1 course for the treatment of, patient is advised to avoid pungent food greasy thing.Follow-up after 3 months, 5 in treatment group's recovery from illness 61
Recurrence, recurrence rate 5.49%；12 recurrences, recurrence rate 52.2% in control group recovery from illness 23.
All above-mentioned this intellectual properties of primarily implementation, the not this new product of implementation of setting limitation other forms
And/or new method.Those skilled in the art will utilize this important information, the above modification, to realize similar execution feelings
Condition.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above described is only a preferred embodiment of the present invention, being not the limitation for making other forms to the present invention, appoint
What those skilled in the art changed or be modified as possibly also with the technology contents of the disclosure above equivalent variations etc.
Imitate embodiment.But it is every without departing from technical solution of the present invention content, the technical spirit according to the present invention is to above example institute
Any simple modification, equivalent variations and the remodeling made, still fall within the protection domain of technical solution of the present invention.
Claims (6)
- A kind of 1. osteophyte-eliminating ointment for being used to eliminate acne, it is characterised in that：By Chinese herbal medicine extract, emulsifying agent, stearic acid, mineral Oil, dimethyl silicone polymer, glycerine, deionized water, EDETATE DISODIUM, essence and preservative composition, the Chinese herbal medicine extract In bulk pharmaceutical chemicals by rheum officinale, thizoma curculiginis, rhizoma imperatae, the flower bud of lily magnolia, peppermint, honey, folium isatidis, halfspreading ironweed herb, Chinese trumpet creeper, luffa, radix ampelopsis, Garden burnet, Radix Salviae Miltiorrhizae, rhizoma alismatis, pivots storage, Chinese torreyanut, leaf of negundo chastetree, Radix Glehniae and reed root composition, the mass percent of above-mentioned each composition are：Chinese herbal medicine extract 0.5~1.5%,Emulsifying agent 1~2%,Stearic acid 1~2%,Mineral oil 6~8%,Dimethyl silicone polymer 2~3%,Glycerine 8~10%,EDETATE DISODIUM 0.05~0.1%,Essence 0.3~0.6%,Preservative 0.1~0.3%,Surplus is deionized water；In the Chinese herbal medicine extract, the parts by weight of its bulk pharmaceutical chemicals are：20~30 parts by weight of rheum officinale, 15~25 weight of thizoma curculiginis Part, 10~20 parts by weight of rhizoma imperatae, 25~35 parts by weight of the flower bud of lily magnolia, 20~30 parts by weight of peppermint, 20~30 parts by weight of honey, smalt 30~40 parts by weight of leaf, 10~20 parts by weight of halfspreading ironweed herb, 15~25 parts by weight of Chinese trumpet creeper, 15~25 parts by weight of luffa, radix ampelopsis 15~25 parts by weight, 10~20 parts by weight of garden burnet, 20~30 parts by weight of Radix Salviae Miltiorrhizae, 15~25 parts by weight, pivots of rhizoma alismatis store 10~20 weights Measure part, 20~30 parts by weight of Chinese torreyanut, 10~20 weight of 10~20 parts by weight of leaf of negundo chastetree, 10~20 parts by weight of Radix Glehniae and reed root Part；A kind of preparation method of above-mentioned osteophyte-eliminating ointment, includes the following steps：1）Each material is weighed according to percentage by weight；2）Prepare Chinese herbal medicine extract；3）Glycerine is disperseed in deionized water, while temperature is increased to 70 ~ 85 DEG C, adds EDETATE DISODIUM, obtains first Phase；4）Emulsifying agent, stearic acid, mineral oil and dimethyl silicone polymer are mixed, obtain the second phase；5）Second is added in the first phase, is stirred evenly, defoaming is cooled to 30 ~ 55 DEG C, then adds Chinese herbal medicine extract, Add essence and preservative, pH value control adds deionized water, stirs evenly discharging, acquisition osteophyte-eliminating ointment 5.0~7.0；The preparation method of above-mentioned Chinese herbal medicine extract includes the following steps：1）Weigh rheum officinale, thizoma curculiginis respectively according to parts by weight, rhizoma imperatae, the flower bud of lily magnolia, peppermint, honey, folium isatidis, halfspreading ironweed herb, reach the clouds Flower, luffa, radix ampelopsis, garden burnet, Radix Salviae Miltiorrhizae, rhizoma alismatis, pivots storage, Chinese torreyanut, leaf of negundo chastetree, Radix Glehniae and reed root；2）It is spare that peppermint is ground into 80 ~ 120 mesh；3）By rheum officinale, thizoma curculiginis, rhizoma imperatae, the flower bud of lily magnolia, folium isatidis, halfspreading ironweed herb, Chinese trumpet creeper, luffa, radix ampelopsis, garden burnet, Radix Salviae Miltiorrhizae, pool Hong, pivots storage, Chinese torreyanut, leaf of negundo chastetree, Radix Glehniae and reed root are respectively crushed into 30 ~ 50 mesh, then add in a reaction vessel and mix, Water extracts 3 ~ 5 times, merges extracting solution, and filtering, macroreticular resin loading, collects eluent, and concentration removes solvent, and vacuum drying, is obtained Get dry extract, be ground into 80 ~ 120 mesh；4）The peppermint powder that second step is obtained, the powder and honey that the 3rd step obtains mix, and obtain Chinese herbal medicine and carry Take thing.
- A kind of 2. osteophyte-eliminating ointment for being used to eliminate acne according to claim 1, it is characterised in that：Each group in the osteophyte-eliminating ointment Point mass percent be：Chinese herbal medicine extract component 1%,Emulsifying agent 1.5%,Stearic acid 1.5%,Mineral oil 7%,Dimethyl silicone polymer 2.5%,Glycerine 9%,EDETATE DISODIUM 0.05%,Essence 0.5%,Preservative 0.2%,Surplus is deionized water.
- A kind of 3. osteophyte-eliminating ointment for being used to eliminate acne according to claim 1, it is characterised in that：The emulsifying agent is third Diol fatty acid ester.
- A kind of 4. osteophyte-eliminating ointment for being used to eliminate acne according to claim 1, it is characterised in that：The preservative is benzene Sodium formate.
- A kind of 5. osteophyte-eliminating ointment for being used to eliminate acne according to claim 1, it is characterised in that：The Chinese herbal medicine extract In, the parts by weight of its bulk pharmaceutical chemicals are：25~30 parts by weight of rheum officinale, 20~25 parts by weight of thizoma curculiginis, 15~20 parts by weight of rhizoma imperatae, 30~35 parts by weight of the flower bud of lily magnolia, 25~30 parts by weight of peppermint, 25~30 parts by weight of honey, 35~40 parts by weight of folium isatidis, halfspreading ironweed herb 15~20 parts by weight, 20~25 parts by weight of Chinese trumpet creeper, 15~20 parts by weight of luffa, 15~20 parts by weight of radix ampelopsis, garden burnet 10~ 15 parts by weight, 20~25 parts by weight of Radix Salviae Miltiorrhizae, 15~20 parts by weight, pivots of rhizoma alismatis store 10~15 parts by weight, 20~25 parts by weight of Chinese torreyanut, 10~15 parts by weight of 10~15 parts by weight of leaf of negundo chastetree, 10~15 parts by weight of Radix Glehniae and reed root.
- A kind of 6. osteophyte-eliminating ointment for being used to eliminate acne according to claim 1, it is characterised in that：In Chinese herbal medicine extract The step 3 of preparation method）In, using D101 macroreticular resin loadings, collect 30~80wt% ethanol eluates.
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|---|---|---|---|---|
| CN101444468A (en) * | 2007-11-28 | 2009-06-03 | 石磊 | Formula of pure traditional Chinese medicine mask for removing acne and clearing scar and preparation process thereof |
| CN101468070A (en) * | 2007-12-27 | 2009-07-01 | 天津天阜康生物技术发展有限公司 | Medicinal composition for treating acne and preparation method thereof |
| CN104434649A (en) * | 2014-11-18 | 2015-03-25 | 天津钧濡科技有限公司 | Acne-removing cosmetic cream |
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