CN104800670A - Traditional Chinese medicine composition for removing freckle and preparation method and application of traditional Chinese medicine composition - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for removing freckles and a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials: 20-30g of divaricate saposhnikovia roots, 10-20g of poria cocos, 40-50g of polygonum cuspidatum, 10-20g of stigma croci, 10-20g of euryale ferox seeds, 20-30g of glossy privet fruit, 20-30g of dandelion, 10-20g of fructus cnidii, 10-20g of notopterygium roots, 20-30g of moutan bark, 20-30g of rhizoma polygonati, 20-30g of semen coicis, 10-20g of tamarix chinensis, 5-15g of vernonia patula, 15-25g of semen cuscutae, 10-20g of hedera helix, 25-35g of burdock, 20-30g of rhizoma cimicifugae, 10-20g of lithospermum, 25-35g of indigo naturalis, 10-20g of kadsura pepper stem 35-45g of folium isatidis and the like. The traditional Chinese medicine composition for removing freckles is remarkable in treatment effect on freckle removal, high in security, very small in adverse reaction and can be applied to cosmetics and medicines.

Description

A kind of for Chinese medicine composition removing freckle and its preparation method and application

Technical field

The present invention relates to a kind of for Chinese medicine composition removing freckle and its preparation method and application, belong to cosmetic technical field.

Background technology

Freckle is a kind of pure brown speckle mainly occurring in skin of face.There is genetic predisposition, greatly about appearance in about 5 years old, increase with the age and increase gradually, being common in women, being apt to occur in face, particularly nose and buccal.Erythra is the speckle of syringe needle to Semen Sesami size, presents brown or dark brown, circular or irregular shape, often multiplely be symmetrically distributed in face, also can betide cervical region, the back of the hand and forearm stretch the exposure portion such as side, not of uniform size, number is indefinite, from sparse several to dense clusters hundreds of.Without any subjective sensation, but freckle hinders beauty treatment, and the people more and more liked to be beautiful adopts various means to remove freckle.

Modern medicine is thought, primary disease is autosomal dominant inheritance, AD is feature, accepts in daylight after UVA Radiation, melanosome in epidermis can be made to become oxidized form rapidly, and make erythra color burn, and form becomes large, increased number.The irradiation of daylight lamp also can make erythra increase the weight of, therefore has people to think, exposing in daylight is a kind of required factor to primary disease erythra.Therefore, in daily life, the people of freckle should note reducing the excessive in shining of daylight.

The conventional method removing freckle has chemical method, laser means and mill skin method, laser means easily causes piebald skin and pigmentation, and costly, if the degree of depth of mill skin method is comparatively difficult to control to penetrate and more deeply can enters subcutaneous tissue and cause permanent cicatrix, chemical method is conventional one, but toxic reaction can be caused by the systemic Absorption of skin generation Chemical peeling agent after Chemical peeling, and the time that postoperative skin is repaired is longer.

Theory of Chinese medical science is thought, the immanent cause that freckle produces is caused by the kidney qi loss that causes of invasion and attack two by wind and cold heat-damp in summer congenital or day after tomorrow.Road is discussed in " the sick duke or princess under an emperor of General Treatise on the Cause and Symptoms of Diseases face body ": " vital organs of the human body 12 menses, all go up in face, all flourish the exterior and the interior of husband's blood trip, or phlegm retention stain is dirty, or film reason wind, cause disharmony between QI and blood, puckery or turbid, can not be flourish in skin, therefore there is black speck." this discussion shows that the traditional Chinese medical science thinks that freckle (facial freckle) is mainly due to deficiency of the kidney, fire stagnation is in the blood system of meridians, and water thanks to can not control fire, fights and be speckle outside ailment said due to cold or exposure.Positive so-called deficiency of kidney-YIN, can not go up flourish in face, the stagnant blood of asthenic fire and be that speckle or element enjoy body stagnant in heat in blood, and offence ailment said due to cold or exposure, heat in blood and ailment said due to cold or exposure are fought mutually and hindered grandson's Yu network, can not Rong Run skin, then raw freckle.

Freckle patient is occurred together endocrine disturbance, and internal metabolism waste deposits forms speckle in face, adds the ultraviolet intense irradiation of sunlight in daily life, causes melanin deposition, generation and intensification.Modern life rhythm is accelerated, and a lot of people is in a kind of state of subhealth state, therefore causes the reason of endocrine disturbance to be many-sided in daily life.Such as emotional upheaval causes irritability must not normally catharsis, causes qi stagnation blood stasis, and also there will be speckle river during the abnormal or hypo-ovaria of the metabolic function of liver, this is also one of reason of endocrine disturbance.If under being in pressure state for a long time, the balance of human metabolism will be destroyed, and people knows from experience secretion epinephrine, and the nutrition supply needed for skin is tending towards slow, and chromoplast will become very active, freckle and then generation.Diet is irregular, physical and psychological pressure is large, sleep daily schedule confusion also all can cause endocrine disturbance to a certain extent.

For effectively regulating the equilibrium between yin and yang of human body, reach the kidney invigorating and hold up spleen, the object for the treatment of both the principal and secondary aspects of a disease, thus well remove freckle, the present invention with dispersing and elevation QI and blood, stimulate the menstrual flow that it is dry for principle to dispel, by adding Chinese herbal medicine extracting composition in facial film, poker meridians, reach ischemia smooth and easy, hold up tonifying five ZANG-organs, make endocrine metabolism balanced, realize dispelling of freckle.

Summary of the invention

The object of this invention is to provide a kind of for Chinese medicine composition removing freckle and preparation method thereof, it is evident in efficacy that this Chinese medicine composition being used for removing freckle removes freckle, and safety is high, and untoward reaction is minimum, can be widely used in cosmetics or medicine.

Technical scheme of the present invention

For removing a Chinese medicine composition for freckle, its prepare raw material used composition and content as follows:

Radix Saposhnikoviae 20-30g

Poria 10-20g

Rhizoma Polygoni Cuspidati 40-50g

Stigma Croci 10-20g

Semen Euryales 10-20g

Fructus Ligustri Lucidi 20-30g

Herba Taraxaci 20-30g

Fructus Cnidii 10-20g

Rhizoma Et Radix Notopterygii 10-20g

Cortex Moutan 20-30g

Rhizoma Polygonati 20-30g

Semen Coicis 20-30g

Ramulus et Folium Tamaricis 10-20g

Herba Vernoniae Patulae 5-15g

Semen Cuscutae 15-25g

Caulis Hederae Sinensis 10-20g

Fructus Arctii 25-35g

Rhizoma Cimicifugae 20-30g

Radix Arnebiae (Radix Lithospermi) 10-20g

Indigo Naturalis 25-35g

Caulis Piperis Kadsurae 10-20g

Folium Isatidis 35-45g

The careless 10-20g of red stalk

Rabbit hair Artemisia 10-20g

Radix Glycyrrhizae 10-20g;

Preferably its prepare raw material composition used and content as follows:

Radix Saposhnikoviae 20-25g

Poria 10-15g

Rhizoma Polygoni Cuspidati 40-45g

Stigma Croci 10-15g

Semen Euryales 10-15g

Fructus Ligustri Lucidi 20-25g

Herba Taraxaci 20-25g

Fructus Cnidii 10-15g

Rhizoma Et Radix Notopterygii 10-15g

Cortex Moutan 20-25g

Rhizoma Polygonati 25-30g

Semen Coicis 25g ~ 30g

Ramulus et Folium Tamaricis 15-20g

Herba Vernoniae Patulae 10-15g

Semen Cuscutae 20g ~ 25g

Caulis Hederae Sinensis 15g ~ 20g

Fructus Arctii 30g ~ 35g

Rhizoma Cimicifugae 25-30g

Radix Arnebiae (Radix Lithospermi) 15-20g

Indigo Naturalis 30-35g

Caulis Piperis Kadsurae 15-20g

Folium Isatidis 40-45g

The careless 15-20g of red stalk

Rabbit hair Artemisia 15-20g

Radix Glycyrrhizae 15-20g;

More preferably its prepare raw material used composition and content as follows:

Radix Saposhnikoviae 25g

Poria 15g

Rhizoma Polygoni Cuspidati 45g

Stigma Croci 15g

Semen Euryales 15g

Fructus Ligustri Lucidi 25g

Herba Taraxaci 25g

Fructus Cnidii 15g

Rhizoma Et Radix Notopterygii 15g

Cortex Moutan 25g

Rhizoma Polygonati 25g

Semen Coicis 25g

Ramulus et Folium Tamaricis 15g

Herba Vernoniae Patulae 10g

Semen Cuscutae 20g

Caulis Hederae Sinensis 15g

Fructus Arctii 30g

Rhizoma Cimicifugae 25g

Radix Arnebiae (Radix Lithospermi) 15g

Indigo Naturalis 30g

Caulis Piperis Kadsurae 15g

Folium Isatidis 40g

The careless 15g of red stalk

Rabbit hair Artemisia 15g

Radix Glycyrrhizae 15g;

The preparation method of described traditional Chinese medicine extraction component is specially to be pulverized, according to above-mentioned respectively by each crude drug component

Weight portion pours mixing in pot into, adds clean cold water, is as the criterion to flood powder, soak 60 minutes, then add cold water, flooded powder 2 ~ 3cm, decoct, after being first heated to boiling with big fire, use little fire instead, maintenance boils to 60 minutes, after crossing filtrate, adds water appropriate, decoct again, filter, merge twice filtrate, concentrating under reduced pressure, except anhydrating, obtains and gets dry extract, and is ground into 100 object fine powders.

Above-mentioned a kind of Chinese medicine composition for removing freckle can be applied in cosmetics and medicine, and the present invention only to be described containing the facial film for the Chinese medicine composition that removes freckle, but does not limit its application in other medicines or cosmetics.

Containing the bate pits facial film of the above-mentioned Chinese medicine composition for removing freckle, its prepare raw material components used and content as follows:

For removing the Chinese medicine composition 2-4g of freckle

Surface active ingredient 0.4-0.6g

Glycerol 10-14g

Polyvinyl alcohol 10-14g

Lactic acid 1-2g

Deionized water 100g;

Described surfactant is fluorine-containing surfactant;

The preparation method of above-mentioned bate pits facial film, specifically comprises the steps:

Polyvinyl alcohol is joined in deionized water, be heated to 60-70 DEG C, polyvinyl alcohol is dissolved completely, be cooled to 45-50 DEG C, then adding glycerol successively, lactic acid stirs, be then cooled to 30-35 DEG C, adding the Chinese medicine composition for removing freckle and surface active ingredient successively, stir, obtain bate pits facial film.

Beneficial effect of the present invention

A kind of Chinese medicine composition for removing freckle of the present invention, due to removing freckle more remarkable treatment effect, safety is high, and untoward reaction is minimum, can apply, and do not affect patient's routine work and study in cosmetics and medicine, is one Therapeutic Method safely and effectively.

Accompanying drawing explanation

The infrared spectrum of the amphoteric surfactant that Fig. 1, the present invention are used.

Detailed description of the invention

The invention provides a kind of bate pits facial film, its raw material comprises traditional Chinese medicine extraction component, surface active ingredient, glycerol, polyvinyl alcohol, lactic acid and deionized water.

Further preferably, described bate pits facial film is only prepared from by above-mentioned raw materials.

In described bate pits facial film, the weight of each raw material is respectively traditional Chinese medicine extraction component 2g ~ 4g, surface active ingredient 0.4g ~ 0.6g, glycerol 10g ~ 14g, polyvinyl alcohol 10g ~ 14g, lactic acid 1g ~ 2g and deionized water 100g.

Further preferably, in described bate pits facial film, the weight of each crude drug is respectively traditional Chinese medicine extraction component 3g, surface active ingredient 0.5g, glycerol 12g, polyvinyl alcohol 12g, lactic acid 1g and deionized water 100g.

Present invention also offers the preparation method of above-mentioned bate pits facial film, comprising:

The first step, preparation traditional Chinese medicine extraction component;

Second step, prepares surface active ingredient;

3rd step, by weight polyvinyl alcohol is joined in deionized water, be heated to 60-70 DEG C, dissolve, be cooled to 45-50 DEG C, add glycerol subsequently, lactic acid stirs, be cooled to 30-35 DEG C further, add traditional Chinese medicine extraction component prepared by the first step and surface active ingredient prepared by second step, stir, obtain facial film.

The crude drug of described traditional Chinese medicine extraction component comprises Radix Saposhnikoviae, Poria, Rhizoma Polygoni Cuspidati, Stigma Croci, Semen Euryales, Fructus Ligustri Lucidi, Herba Taraxaci, Fructus Cnidii, Rhizoma Et Radix Notopterygii, Cortex Moutan, Rhizoma Polygonati, Semen Coicis, Ramulus et Folium Tamaricis, Herba Vernoniae Patulae, Semen Cuscutae, Caulis Hederae Sinensis, Fructus Arctii, Rhizoma Cimicifugae, Radix Arnebiae (Radix Lithospermi), Indigo Naturalis, Caulis Piperis Kadsurae, Folium Isatidis, red stalk grass, rabbit hair Artemisia and Radix Glycyrrhizae.

Further preferably, described traditional Chinese medicine extraction component is only prepared from by above-mentioned raw materials medicine.

The weight of each crude drug is respectively Radix Saposhnikoviae 20g ~ 30g, Poria 10g ~ 20g, Rhizoma Polygoni Cuspidati 40g ~ 50g, Stigma Croci 10g ~ 20g, Semen Euryales 10g ~ 20g, Fructus Ligustri Lucidi 20g ~ 30g, Herba Taraxaci 20g ~ 30g, Fructus Cnidii 10g ~ 20g, Rhizoma Et Radix Notopterygii 10g ~ 20g, Cortex Moutan 20g ~ 30g, Rhizoma Polygonati 20g ~ 30g, Semen Coicis 20g ~ 30g, Ramulus et Folium Tamaricis 10g ~ 20g, Herba Vernoniae Patulae 5g ~ 15g, Semen Cuscutae 15g ~ 25g, Caulis Hederae Sinensis 10g ~ 20g, Fructus Arctii 25g ~ 35g, Rhizoma Cimicifugae 20g ~ 30g, Radix Arnebiae (Radix Lithospermi) 10g ~ 20g, Indigo Naturalis 25g ~ 35g, Caulis Piperis Kadsurae 10g ~ 20g, Folium Isatidis 35g ~ 45g, careless 10g ~ the 20g of red stalk, rabbit hair Artemisia 10g ~ 20g and Radix Glycyrrhizae 10g ~ 20g.

Further preferably, the weight of each crude drug is respectively Radix Saposhnikoviae 20g ~ 25g, Poria 10g ~ 15g, Rhizoma Polygoni Cuspidati 40g ~ 45g, Stigma Croci 10g ~ 15g, Semen Euryales 10g ~ 15g, Fructus Ligustri Lucidi 20g ~ 25g, Herba Taraxaci 20g ~ 25g, Fructus Cnidii 10g ~ 15g, Rhizoma Et Radix Notopterygii 10g ~ 15g, Cortex Moutan 20g ~ 25g, Rhizoma Polygonati 25g ~ 30g, Semen Coicis 25g ~ 30g, Ramulus et Folium Tamaricis 15g ~ 20g, Herba Vernoniae Patulae 10g ~ 15g, Semen Cuscutae 20g ~ 25g, Caulis Hederae Sinensis 15g ~ 20g, Fructus Arctii 30g ~ 35g, Rhizoma Cimicifugae 25g ~ 30g, Radix Arnebiae (Radix Lithospermi) 15g ~ 20g, Indigo Naturalis 30g ~ 35g, Caulis Piperis Kadsurae 15g ~ 20g, Folium Isatidis 40g ~ 45g, careless 15g ~ the 20g of red stalk, rabbit hair Artemisia 15g ~ 20g and Radix Glycyrrhizae 15g ~ 20g.

Most preferably, the weight of each crude drug is respectively Radix Saposhnikoviae 25g, Poria 15g, Rhizoma Polygoni Cuspidati 45g, Stigma Croci 15g, Semen Euryales 15g, Fructus Ligustri Lucidi 25g, Herba Taraxaci 25g, Fructus Cnidii 15g, Rhizoma Et Radix Notopterygii 15g, Cortex Moutan 25g, Rhizoma Polygonati 25g, Semen Coicis 25g, Ramulus et Folium Tamaricis 15g, Herba Vernoniae Patulae 10g, Semen Cuscutae 20g, Caulis Hederae Sinensis 15g, Fructus Arctii 30g, Rhizoma Cimicifugae 25g, Radix Arnebiae (Radix Lithospermi) 15g, Indigo Naturalis 30g, Caulis Piperis Kadsurae 15g, Folium Isatidis 40g, red stalk grass 15g, rabbit hair Artemisia 15g and Radix Glycyrrhizae 15g.

Each crude drug pharmacology is as follows:

Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature, enters lung, liver, spleen, urinary bladder channel, has expelling cold and relieving exterior syndrome, removing dampness to relieve pain, expelling wind and relieving convulsion, antipruritic effect, is mainly used in affection of exogenous wind-cold card and cold-evil's closing, the syndrome of superficies cold and interior heat etc. of interior-heat pent-up.

Poria: sweet in the mouth, light, property is put down, and enters spleen, lung, bladder, heart channel, has the effect of eliminating dampness and diuresis, spleen invigorating mind calming, be mainly used in the edema of retention of water-damp, dysuria; The pyretic stranguria of damp-heat accumulation, the card such as anorexia and loose stool, phlegm retention stagnation, epilepsy of stagnation of dampness due to deficiency of the spleen.

Rhizoma Polygoni Cuspidati: latin name Polygoni Cuspidati Rhizoma et Radix, micro-hardship, is slightly cold.Return liver, gallbladder, lung meridian, there is heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, effect of relieving cough and resolving phlegm, for arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, the cards such as carbuncle sore tumefacting virus.

Stigma Croci: latin name Tamaricis Cacumen, the delicate branch and leaf of the drying for Cacumen Tamaricis section plant Cacumen Tamaricis, sweet in the mouth, property is put down, energy blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens, pain relieving.Be used for the treatment of troubled thoughts pent-up, chest and diaphragm painful abdominal mass is vexed, and spit blood, typhoid fever is gone mad, and frightened fear in a trance, women's amenorrhea, stasis menoxenia, prolonged lochia, blood stasis is had a pain, measles, the cards such as traumatic injury.

Semen Euryales: sweet in the mouth, puckery, property is put down.Return spleen, kidney channel.Have supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, the function of damp eliminating leukorrhagia stopping, cures mainly emission, diarrhea due to hypofunction of the spleen, and insufficiency of the spleen nebulousurine is with inferior card.

Fructus Ligustri Lucidi: sweet in the mouth, hardship, be slightly cold, enters liver, kidney channel, has strong liver kidney tonifying, the effect of clearing away heat to improve acuity of vision, is mainly used in treating hepatic and renal YIN deficiency, and the head loses foster dizzy tinnitus, the cards such as yin asthenia generating intrinsic heat.

Herba Taraxaci: latin name Taraxaci Herba, sweet in the mouth, hardship, cold in nature, enter liver, stomach warp, there is the effect of heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, liver heat removing and eyesight improving, inducing diuresis for treating stranguria syndrome, be mainly used in the treatment of sore swollen toxin, especially remarkable to acute mastitis effect, also can be used for the cards such as the conjunctival congestion and swelling pain of flaming up of liver-fire.

Fructus Cnidii: latin name cnidii fructus, acrid in the mouth, hardship, warm in nature, enter kidney channel, have the effect of warming the kidney to invigorate YANG, removing dampness and killing parasites, dispelling wind for relieving itching, the impotence in male caused for kidney yang deficiency, woman's cold womb are infertile, the cards such as cold-damp leukorrhagia or chills and pain of the waist and kness.

Rhizoma Et Radix Notopterygii: acrid in the mouth, hardship, warm in nature, enter kidney, urinary bladder channel, have effect of the cold expelling that induces sweat, expelling wind and dampness, pain relieving, have the wet exterior syndrome of wind and cold folder, disease sees that fever with aversion to cold, headache are as wrapped up in, neck rigid back pain, the cards such as limbs are heavy, and joint is ached, anemofrigid-damp arthralgia.

Cortex Moutan: cold in nature, bitter in the mouth, GUIXIN, liver, kidney, lung meridian, have effect of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, for the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, the calentura later stage, hot Fu Yin divided heating, deficiency of YIN osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury, the cards such as beriberoid pyretic arthralgia.

Rhizoma Polygonati: sweet in the mouth, property is put down, and enter lung, spleen, kidney channel, have nourishing kidney lung moistening, the effect of invigorating the spleen and replenishing QI, for lung-dryness syndrome due to deficiency of YIN, dry cough expectorant is few, polydipsia of quenching one's thirst, weakness of the spleen and stomach, deficiency of spleen-QI or deficiency of spleen-YIN, deficiency of kidney essence, soreness of the waist and knees, the cards such as early whitening of beard and hair.

Semen Coicis: cool in nature, sweet in the mouth, light, return spleen, stomach, lung meridian, have the function of spleen invigorating eliminating dampness by diuresis, clearing away heat and discharging pus, eliminating impediment, diuretic, for weakness of the spleen and stomach, suffer from diarrhoea in loose stool, or vaginal discharge diseases of women, insufficiency of the spleen leading to overabundance of dampness edema, dysuria, or beriberi swells and ache; Damp and hot arthralgia pain, contracture of the limbs, miserable pain; Lung abscess cough and spit purulent sputum, or enterodynia contracture stomachache.

Ramulus et Folium Tamaricis: be the browse of suspend platymiscium Ramulus et Folium Tamaricis, sweet in the mouth, pungent, property is put down, and return lung, stomach, heart channel, have dispelling wind, induce sweat, rash, effect of removing toxic substances, cures mainly anemopyretic cold, measles from the beginning of, rash goes out saturating, rheumatic arthralgia, the cards such as skin pruritus.

Herba Vernoniae Patulae: be the herb of ironweed plant Herba Vernoniae Patulae, bitter in the mouth, pungent, property is put down, and has wind and heat dispersing, dampness removing, effect of detumescence, cures mainly cold, fever, dysentery, headache due to hyperactivity of liver-YANG, hypertension, have loose bowels, rheumatic arthralgia, eczema, urticaria, furuncle, acute mastitis, traumatic injury, ulcerous nonunion, the cards such as manihot poisoning.

Semen Cuscutae: sweet in the mouth, pungent, property is put down, and returns liver,kidney,spleen warp, has the kidney invigorating and essence nourishing, the effect of nourishing the liver to improve visual acuity, be mainly used in the sexual impotence of insufficiency of kidney-YANG, seminal emission premature ejaculation, frequent micturition, dizziness and tinnitus; To suffer from a deficiency of the kidney pain in the lumbar region, married woman's leukorrhagia, nausea is solid; The binocular of both liver and kidney deficiency, deficiency of liver-blood is dim-sighted, blurring of vision; The loose stool stomachache of asthenia of both the spleen and kidney, the cards such as aqueous-grainy diarrhea.

Caulis Hederae Sinensis: acrid in the mouth, hardship, property is put down, and returns liver, spleen, lung meridian, has and dispel the wind, dampness removing, and blood, and effect of removing toxic substances, cures mainly rheumatic arthralgia, headache, dizzy, hepatitis, traumatic injury, laryngopharynx swelling and pain, carbuncle multiple abscess, the cards such as snake bite and insect sting.

Fructus Arctii: acrid in the mouth is bitter; Cold in nature, return lung, stomach warp, has dispelling wind and heat pathogens, heat-clearing and toxic substances removing rash, and lung qi dispersing sore-throat relieving falls apart swollen effect, cure mainly anemopyretic cold, epidemic febrile disease from the beginning of; Wind heat or cough due to lung-heat, cough up phlegm not smooth; Laryngopharynx swelling and pain; Macule is not saturating; At the measles initial stage, rash goes out not smooth and rubella pruritus; The card such as sore swollen toxin and mumps.

Rhizoma Cimicifugae: acrid in the mouth, micro-sweet, cold nature, enters lung, spleen, stomach, large intestine channel, has and deliver rash, heat-clearing and toxic substances removing, effect of elevate a turnable ladder yang-energy.For headache due to pathogenic wind-heat, toothache, aphtha, laryngopharynx swelling and pain, measles without adequate eruption, YANG toxin syndrome sends out speckle; Proctoptosis, the cards such as uterine prolapse.

Radix Arnebiae (Radix Lithospermi): cold in nature, sweet in the mouth, salty, GUIXIN, Liver Channel, have removing heat from blood and promoting blood circulation, effect of removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.Clearing away heat and cooling blood, for measles, calentura skin eruption, eczema, hematuria, stranguria with blood, dysentery, skin infection, erysipelas, burn, the cards such as constipation with heat retention.

Indigo Naturalis: salty in the mouth, cold in nature, enter Liver Channel, there is effect of heat-clearing and toxic substances removing, cooling blood for hemostasis, purging liver-fire, send out the cards such as all cards of pyretic toxicity such as speckle, haematemesis, laryngopharynx swelling and pain, herpes eczema, liver-fire invading the lung, cough chest pain, sputum mixed with blood, high hot infantile convulsion, convulsion with spasms for epidemic febrile disease.

Caulis Piperis Kadsurae: acrid in the mouth, hardship, slightly warm in nature, returns Liver Channel, has wind-damp dispelling, the meridian dredging, and effect of stopping numbness pain, cures mainly anemofrigid-damp arthralgia, arthrodynia of extremities, the contracture of muscle arteries and veins, the cards such as joint stuffiness.

Folium Isatidis: latin name Isatidis Folium, bitter in the mouth, property Great Cold, GUIXIN, liver, gallbladder, stomach warp, have antipyretic and detoxicated, cooling blood and dissolving purpura, effect of jaundice eliminating, can the excess-heat that divides of clearing heat in QI system, can separate again the pyretic toxicity of blood system, the high febrile perspiration being mainly used in pestilence calentura caused goes out, excessive thirst taking fluids profusely; The speckle that fire-toxin is flourishing is gone mad, the symptoms such as haematemesis; The unconsciousness due to high fever of measles, rash color is purple dark; Dampness-heat in the liver and gallbladder accumulates the jaundice of steaming; The deafness and tinnitus of liver and gall fire liter; The card such as pharyngalgia, aphtha of the mouth and tongue, hepatitis that fire stagnation pyretic toxicity is caused.

Red stalk grass: be the herb of the different leaf Herba Lycopi of Compositae feverwort, sweet in the mouth, hardship, slightly warm in nature, returns liver, kidney channel, has promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, effect of dehumidifying row water, cures mainly menoxenia, amenorrhea, stomachache, disease that postpartum lochia can't go, edema, traumatic injury, the cards such as fracture.

Rabbit hair Artemisia: be the herb of Compositae line Dendranthema Filifolium sibiricum (Linn.) Kitam., bitter in the mouth, cold in nature, there is heat-clearing and toxic substances removing, anti-inflammation, calm the nerves relieving convulsion, effect of regulating menstruation, hemostasis, cure mainly the high heat of infectious disease, heart beating, insomnia, neurasthenia, menorrhagia, the cards such as menoxenia.

Radix Glycyrrhizae: latin name Glycyrrhizae Radix et Rhizoma, sweet in the mouth, property put down, enter 12 warps, have heat-clearing and toxic substances removing, be in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak; Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play QI invigorating neutralization by adding Radix Glycyrrhizae, is in harmonious proportion the work of each component.

The preparation method of described traditional Chinese medicine extraction component is specially to be pulverized respectively by each crude drug component, pours in pot and mixes, add clean cold water, be as the criterion to flood powder according to above-mentioned weight portion, soak 60 minutes, then add cold water, flooded powder 2 ~ 3cm, decoct, after being first heated to boiling with big fire, use little fire instead, maintenance boils to 60 minutes, after crossing filtrate, adds water appropriate, decoct again, filter, merge twice filtrate, concentrating under reduced pressure, except anhydrating, obtains and gets dry extract, and is ground into 100 object fine powders.

Described surfactant is fluorine-containing surfactant, is preferably amphoteric fluorotensides, as the amphoteric fluorotensides of the routines such as perfluoroalkyl betain, and preferred amphoteric fluorotensides shown in following formula further.

。

Wherein, n is 10-10000, is preferably 50-3000.

The preparation method of the surfactant shown in this formula is specially and thermometer is being housed, in the reactor of reflux condensing tube, add fluorochemical monomer trifluoroethyl methacrylate 16.812 g (0.1 mol), chloropropene 7.653 g (0.1 mol), acrylic acid 7.206 g (0.1 mol) and appropriate distilled water are as solvent, then 1.077g (0.008mol) anhydrous sodium sulfite and 0.839g (0.037mol) Ammonium persulfate. is added, pH 7.0 ~ 7.5 is regulated with ammonia, 10 h ~ 12 h are reacted under 50 DEG C ~ 60 DEG C stirrings, disposablely add trimethylamine 10.747 g (0.12mol), slow cooling to 40 DEG C, continue stirring reaction 4 h again, stopped reaction, after repeatedly purifying with dehydrated alcohol, water, ethanol in distilling under reduced pressure removing solution, obtain final sticky product amphoteric fluorotensides 30.441 g.

This preparation method is only one and illustrates, can according to above-mentioned mol ratio relation preparation in actual fabrication process.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1

Traditional Chinese medicine extraction component 1

By Radix Saposhnikoviae 25g, Poria 15g, Rhizoma Polygoni Cuspidati 45g, Stigma Croci 15g, Semen Euryales 15g, Fructus Ligustri Lucidi 25g, Herba Taraxaci 25g, Fructus Cnidii 15g, Rhizoma Et Radix Notopterygii 15g, Cortex Moutan 25g, Rhizoma Polygonati 25g, Semen Coicis 25g, Ramulus et Folium Tamaricis 15g, Herba Vernoniae Patulae 10g, Semen Cuscutae 20g, Caulis Hederae Sinensis 15g, Fructus Arctii 30g, Rhizoma Cimicifugae 25g, Radix Arnebiae (Radix Lithospermi) 15g, Indigo Naturalis 30g, Caulis Piperis Kadsurae 15g, Folium Isatidis 40g, the careless 15g of red stalk, rabbit hair Artemisia 15g and Radix Glycyrrhizae 15g pulverizes respectively, pour mixing in pot into, add clean cold water, be as the criterion to flood powder, soak 60 minutes, add cold water again, flooded powder 2 ~ 3cm, decoct, after being first heated to boiling with big fire, use little fire instead, maintenance boils to 60 minutes, after crossing out filtrate, add water appropriate, decoct again, filter, merge twice filtrate, concentrating under reduced pressure is except anhydrating, obtain and get dry extract, be ground into 100 object fine powders.

Embodiment 2 traditional Chinese medicine extraction component 2

By Radix Saposhnikoviae 20g, Poria 10g, Rhizoma Polygoni Cuspidati 40g, Stigma Croci 10g, Semen Euryales 10g, Fructus Ligustri Lucidi 20g, Herba Taraxaci 20g, Fructus Cnidii 10g, Rhizoma Et Radix Notopterygii 10g, Cortex Moutan 20g, Rhizoma Polygonati 25g, Semen Coicis 25g, Ramulus et Folium Tamaricis 15g, Herba Vernoniae Patulae 10g, Semen Cuscutae 20g, Caulis Hederae Sinensis 15g, Fructus Arctii 30g, Rhizoma Cimicifugae 25g, Radix Arnebiae (Radix Lithospermi) 15g, Indigo Naturalis 30g, Caulis Piperis Kadsurae 15g, Folium Isatidis 40g, the careless 15g of red stalk, rabbit hair Artemisia 15g and Radix Glycyrrhizae 15g pulverizes respectively, pour mixing in pot into, add clean cold water, be as the criterion to flood powder, soak 60 minutes, add cold water again, flooded powder 2 ~ 3cm, decoct, after being first heated to boiling with big fire, use little fire instead, maintenance boils to 60 minutes, after crossing out filtrate, add water appropriate, decoct again, filter, merge twice filtrate, concentrating under reduced pressure is except anhydrating, obtain and get dry extract, be ground into 100 object fine powders.

Embodiment 3 traditional Chinese medicine extraction component 3

By Radix Saposhnikoviae 25g, Poria 15g, Rhizoma Polygoni Cuspidati 45g, Stigma Croci 15g, Semen Euryales 15g, Fructus Ligustri Lucidi 25g, Herba Taraxaci 25g, Fructus Cnidii 15g, Rhizoma Et Radix Notopterygii 15g, Cortex Moutan 25g, Rhizoma Polygonati 30g, Semen Coicis 30g, Ramulus et Folium Tamaricis 20g, Herba Vernoniae Patulae 15g, Semen Cuscutae 25g, Caulis Hederae Sinensis 20g, Fructus Arctii 35g, Rhizoma Cimicifugae 30g, Radix Arnebiae (Radix Lithospermi) 20g, Indigo Naturalis 35g, Caulis Piperis Kadsurae 20g, Folium Isatidis 45g, the careless 20g of red stalk, rabbit hair Artemisia 20g and Radix Glycyrrhizae 20g pulverizes respectively, pour mixing in pot into, add clean cold water, be as the criterion to flood powder, soak 60 minutes, add cold water again, flooded powder 2 ~ 3cm, decoct, after being first heated to boiling with big fire, use little fire instead, maintenance boils to 60 minutes, after crossing out filtrate, add water appropriate, decoct again, filter, merge twice filtrate, concentrating under reduced pressure is except anhydrating, obtain and get dry extract, be ground into 100 object fine powders.

Embodiment 4 toxicology detects

Acute toxicity test

Animal: Kunming mouse, body weight 21 ~ 24g, male and female half and half.

LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, often organize 10, male and female half and half, traditional Chinese medicine extraction component 1 adding distil water embodiment 1 prepared dissolves, and is made into Cmax, by the administration of mice maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g/kg), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

Maximum tolerated dose measures (MTD value): get mice 20, each 10 of male and female.Traditional Chinese medicine extraction component 1 adding distil water embodiment 1 prepared dissolves, and is made into maximum concentration, by the maximum tolerated dose of animal, feeds device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in a day (interval half an hour), each 0.5ml (every ml is containing crude drug 0.36g), total dose is 18g crude drug/kgd.Continuous Observation 7 days after administration.

Result of the test

In LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kgd), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death, show that acute toxicity is minimum, MTD > 18g/Kgd.

Aggregate toxicity is tested

Traditional Chinese medicine extraction component 1 adding distil water embodiment 1 prepared dissolves, to mice by 7.69,19.18 and 43.21g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to rat all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after rat long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Embodiment 5 surfactant 1

In the reactor that thermometer, reflux condensing tube are housed; add fluorochemical monomer trifluoroethyl methacrylate 16.812 g (0.1 mol), chloropropene 7.653 g (0.1 mol), acrylic acid 7.206 g (0.1 mol) and appropriate distilled water as solvent; then anhydrous sodium sulfite and Ammonium persulfate. is added; regulate pH 7.0 ~ 7.5 with ammonia, under 50 DEG C ~ 60 DEG C stirrings, react 10 h ~ 12 h; Disposablely add trimethylamine 10.747 g (0.12mol), slow cooling to 40 DEG C, continue stirring reaction 4 h again, stopped reaction, after repeatedly purifying with dehydrated alcohol, water, ethanol in distilling under reduced pressure removing solution, obtain final sticky product amphoteric fluorotensides 30.441 g.

The infrared spectrum of surfactant is in table 1.

Embodiment 6 facial film 1

Polyvinyl alcohol 12g is joined in deionized water 100g, be heated to 70 DEG C, dissolve, be cooled to 50 DEG C, add glycerol 12g subsequently, lactic acid 1g stirs, be cooled to 30 DEG C further, add the traditional Chinese medicine extraction component 3g of embodiment 1 preparation and the surface active ingredient 0.5g of embodiment 5 preparation, stir, obtain facial film 1.

Embodiment 7 facial film 2

Polyvinyl alcohol 12g is joined in deionized water 100g, be heated to 70 DEG C, dissolve, be cooled to 50 DEG C, add glycerol 12g subsequently, lactic acid 1g stirs, be cooled to 30 DEG C further, add traditional Chinese medicine extraction component 3g and the surface active ingredient perfluoroalkyl betain 0.5g of embodiment 1 preparation, stir, obtain facial film 2.

Embodiment 8 facial film 3

Polyvinyl alcohol 12g is joined in deionized water 100g, is heated to 70 DEG C, dissolve, be cooled to 50 DEG C, add glycerol 12g subsequently, lactic acid 1g stirs, be cooled to 30 DEG C further, add surface active ingredient 0.5g prepared by embodiment 5, stir, obtain facial film 3.

Embodiment 9 zest detects

By healthy adult white, man exempts from 21, body weight 2.5 ~ 2.7kg, male and female half and half, is divided into 3 groups, often organizes 7.By its spinal column both sides skin unhairing 3cm × 3cm, facial film 1 to facial film 3 prepared by Example 6 to embodiment 8, is coated on respectively on 3 groups of plucked skins in family's rabbit back side, covers with one deck cellophane, fixed with nonirritant medical proof fabric and binder, opposite side distilled water compares again.Every experimental animal is applied ointment or plaster after 4h, removes tested material, with the skin of warm water cleaning application site, respectively at 1,24,48h observes and records the dermoreaction of application site, the standards of grading specified according to " disinfection technology standard " and classification are marked.Irritation test shows, facial film provided by the invention is 0 to rabbit skin wound repair integration, and skin, without erythema, belongs to non-stimulated.

Embodiment 10 freckle effect

Physical data

Totally 300 routine freckle patients, at minimum 18 years old of age, maximum 48 years old, 8 years that the course of disease is the longest, the shortest 2 years, are women, are divided into 3 groups at random, often organize 100 routine patients.

Therapeutic Method

Treat 1 group: employing percussopunctator is kowtowed to tattoo the face of a criminal and send him into exile and closed facial film 1 external application for curing of embodiment 6 preparation, treat facial film 2 external application for curing that conjunction embodiment 7 preparation of tattooing the face of a criminal and send him into exile kowtowed by 2 groups of employing percussopunctators, matched group employing percussopunctator is kowtowed to tattoo the face of a criminal and send him into exile and is closed facial film 3 external application for curing of embodiment 8 preparation, above patient all fears pain, refusal laser therapy.1 30 days course for the treatment of, take 3 courses for the treatment of generally continuously, take a good rest at ordinary times, avoid sun exposure.

Curative effect determinate standard

Recovery from illness: after 3 courses for the treatment of, brown spot point obviously disappears; Effective: after 3 courses for the treatment of, brown spot point is obviously thin out, and scope obviously reduces; Effective: after 3 courses for the treatment of, yellowish-brown speckle is thin out to shoal, range shorter; Invalid: after 3 courses for the treatment of, yellowish-brown speckle is without any change.

Statistical procedures

Follow-up Data is organized into grade frequency table form, adopts two independent sample non parametric testss (rank test) in statistic software SPSS 13.0 to carry out statistical procedures.

Result

Two groups of effectiveness comparison, the results are shown in Table 1.

Table 1 liang group effectiveness comparison example

Group	Number of cases	Recovery from illness	Effective	Effectively	Invalid	Total effective rate (%)
							Treat 1 group	100	62	18	12	8	92.0
Treat 2 groups	100	43	25	19	13	87.0
							Matched group	100	19	21	29	31	69.0

Compared with matched group, adopt facial film provided by the invention removing Be very effective in freckle, p<0.01, there is comparability, comparison therapy 1 group and treatment 2 groups, the surfactant adopting embodiment 5 to prepare more can promote that traditional Chinese medicine extraction component is removing the effect in freckle.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (6)

1. for removing a Chinese medicine composition for freckle, it is characterized in that, the described Chinese medicine composition for removing freckle, its prepare raw material components used and content as follows:

Radix Saposhnikoviae 20-30g

Poria 10-20g

Rhizoma Polygoni Cuspidati 40-50g

Stigma Croci 10-20g

Semen Euryales 10-20g

Fructus Ligustri Lucidi 20-30g

Herba Taraxaci 20-30g

Fructus Cnidii 10-20g

Rhizoma Et Radix Notopterygii 10-20g

Cortex Moutan 20-30g

Rhizoma Polygonati 20-30g

Semen Coicis 20-30g

Ramulus et Folium Tamaricis 10-20g

Herba Vernoniae Patulae 5-15g

Semen Cuscutae 15-25g

Caulis Hederae Sinensis 10-20g

Fructus Arctii 25-35g

Rhizoma Cimicifugae 20-30g

Radix Arnebiae (Radix Lithospermi) 10-20g

Indigo Naturalis 25-35g

Caulis Piperis Kadsurae 10-20g

Folium Isatidis 35-45g

The careless 10-20g of red stalk

Rabbit hair Artemisia 10-20g

Radix Glycyrrhizae 10-20g;

The above-mentioned preparation method for the Chinese medicine composition removing freckle is specially:

Each crude drug component is pulverized respectively, pours in pot according to above-mentioned weight portion and mix, add clean cold water, be as the criterion to flood powder, soak 60 minutes, then add cold water, flooded powder 2 ~ 3cm, decoct, after being first heated to boiling with big fire, use little fire instead, maintenance boils to 60 minutes, after crossing filtrate, adds water appropriate, decoct again, filter, merge twice filtrate, concentrating under reduced pressure, except anhydrating, obtains and gets dry extract, and is ground into 100 object fine powders.

2. a kind of Chinese medicine composition for removing freckle as claimed in claim 1, is characterized in that, its prepare raw material components used and content as follows:

Preferably its prepare raw material composition used and content as follows:

Radix Saposhnikoviae 20-25g

Poria 10-15g

Rhizoma Polygoni Cuspidati 40-45g

Stigma Croci 10-15g

Semen Euryales 10-15g

Fructus Ligustri Lucidi 20-25g

Herba Taraxaci 20-25g

Fructus Cnidii 10-15g

Rhizoma Et Radix Notopterygii 10-15g

Cortex Moutan 20-25g

Rhizoma Polygonati 25-30g

Semen Coicis 25g ~ 30g

Ramulus et Folium Tamaricis 15-20g

Herba Vernoniae Patulae 10-15g

Semen Cuscutae 20g ~ 25g

Caulis Hederae Sinensis 15g ~ 20g

Fructus Arctii 30g ~ 35g

Rhizoma Cimicifugae 25-30g

Radix Arnebiae (Radix Lithospermi) 15-20g

Indigo Naturalis 30-35g

Caulis Piperis Kadsurae 15-20g

Folium Isatidis 40-45g

The careless 15-20g of red stalk

Rabbit hair Artemisia 15-20g

Radix Glycyrrhizae 15-20g.

3. a kind of Chinese medicine composition for removing freckle as claimed in claim 1, is characterized in that, its prepare raw material components used and content as follows:

Radix Saposhnikoviae 25g

Poria 15g

Rhizoma Polygoni Cuspidati 45g

Stigma Croci 15g

Semen Euryales 15g

Fructus Ligustri Lucidi 25g

Herba Taraxaci 25g

Fructus Cnidii 15g

Rhizoma Et Radix Notopterygii 15g

Cortex Moutan 25g

Rhizoma Polygonati 25g

Semen Coicis 25g

Ramulus et Folium Tamaricis 15g

Herba Vernoniae Patulae 10g

Semen Cuscutae 20g

Caulis Hederae Sinensis 15g

Fructus Arctii 30g

Rhizoma Cimicifugae 25g

Radix Arnebiae (Radix Lithospermi) 15g

Indigo Naturalis 30g

Caulis Piperis Kadsurae 15g

Folium Isatidis 40g

The careless 15g of red stalk

Rabbit hair Artemisia 15g

Radix Glycyrrhizae 15g.

4. the preparation method of a kind of Chinese medicine composition for removing freckle as described in as arbitrary in claim 1-3, is characterized in that:

Each crude drug component is pulverized respectively, pours in pot according to above-mentioned weight portion and mix, add clean cold water, be as the criterion to flood powder, soak 60 minutes, then add cold water, flooded powder 2 ~ 3cm, decoct, after being first heated to boiling with big fire, use little fire instead, maintenance boils to 60 minutes, after crossing filtrate, adds water appropriate, decoct again, filter, merge twice filtrate, concentrating under reduced pressure, except anhydrating, obtains and gets dry extract, and is ground into 100 object fine powders.

5. a kind of Chinese medicine composition for removing freckle as described in as arbitrary in claim 1-3 is applied preparing in cosmetics or medicine.

6. the application of a kind of Chinese medicine composition for removing freckle as described in as arbitrary in claim 1-3 in preparation bate pits facial film.