CN103405698A - Traditional Chinese medicine liniment for treating acnes and preparation method thereof - Google Patents
Traditional Chinese medicine liniment for treating acnes and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine liniment for treating acnes. The traditional Chinese medicine liniment is prepared from the following materials in parts by weight: 10-20 parts of indigo naturalis, 15-25 parts of fructus kochiae, 15-25 parts of rheum officinale, 20-25 parts of folium isatidis, 15-25 parts of rhizoma atractylodis, 15-20 parts of fructus evodiae, 10-20 parts of flax, 15-25 parts of angelica sinensis, 15-25 parts of raw liquorice, 25-40 parts of garden burnet, 25-45 parts of oriental wormwood, 30-40 parts of oldenlandia diffusa, 15-25 parts of frankincense, 15-25 parts of sangusis draconis, 20-30 parts of radix stemonae, 15-25 parts of gallnut, 10-20 parts of cortex dictamni, 15-25 parts of myrrh, 15-25 parts of radix angelicae, 15-25 parts of root of red-rooted salvia, 20-25 parts of root of common peony, 15-25 parts of isatis root, and 15-25 parts of flowers carthami. The traditional Chinese medicine liniment can effectively treat kinds of acnes, and has the characteristics of being safe, free of toxic and side effects, convenient to use, and high in recovery rate.
Description
Technical field
The invention belongs to a kind of Chinese herbal and crude drugs preparations, specifically a kind of Chinese medicine preparation of Acne treatment.
Background technology
Along with the raising of people's living standard, the renewal of dietary structure, the change of life style, the increase of study and work pressure, the anxiety of inter personal contact, the variation of mental emotion, the pollution of poor environment etc., cause patients with acne to grow with each passing day.The clinical observation discovery, the maximum colony of suffering from present acne has two: adolescence men and women and blue or green female middle-aged.And blue or green female middle-aged acne prevalence has the trend of growth.The sickness rate of primary disease in the crowd is 20%-24% according to investigations, in the adolescence men and women up to 30%-50%.In a single day primary disease is suffered from, outbreak repeatedly, and touching difficulty is more.Life, work, social activity to the patient cause certain pressure, even can cause feel oneself inferior, the mental symptom such as anxiety.This not only causes bad impact to patient physiological and psychology, has more increased the weight of patient's spirit and financial burden.
Primary disease sees classic of TCM Huangdi's Internal Classics the earliest, says as " a Plain Questions vital QI of the body connecting with natural QI opinion piece of writing ": " sweating is shown in wet, is give birth to Cuo not ", " exposure to the wind after sweating due to overstrain, invasion of pathogenic cold are Zha, and strongly fragrant is Cuo ".Zhang Jiebin annotates: " sweating of shape labor, sitting and lying work as wind, cold thin it, liquid is solidifying is Zha, namely acne also, if strongly fragrant and slightly large, are into trifle, are to say Cuo." disclosed the cause of disease and the pathogeny of acne.Shanxi Ge Hong handbook of Prescription for Emergency cloud: " a year weak breath is filled, the bleb of looking unfamiliar skin ulcer " recognizes that morbidity is relevant with the age, is that the arrogant Yang Wang of adolescence makes so.Record in Sui's Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases face Blisters time ": " face Blisters person, have wind heat gas to give birth to Blisters on the meaning face, head as rice are large, and also as large as paddy, white person is also." set forth the cause of disease and the skin lesion feature of acne.
Chinese medicine thinks, it is stifling that the primary disease pathogenesis mostly is lung-heat, and heat in blood is accumulate the resistance skin and formed; Or because the intestines and stomach is damp and hot, because of the pungent greasy product of surfeit, living humidogene accumulation of heat is stagnant in intestinal, can not be descending contrary upper on the contrary, hinder in skin and form; Or strong because of temper, the transporting imbalance, with the passing of time give birth to expectorant, and the damp-stagnancy heat-transformation, due to damp and hot folder expectorant, the skin that stagnates; Or interspaces of skin and muscles being loose, outer painting cosmetics are improper, medicine irritation and causing a disease.
Doctor trained in Western medicine thinks that acne has multiple pathogenic factors, and it is the principal element of acne that endocrine factors, sebum secretion are crossed microorganism in Sheng, hair follicle.Secondly, the immune genetic factors are also relevant with the generation of acne, due to the endocrine disturbance, androgen secretion is too high, cause the smegma hyperfunctioning, too much sebum secretion causes sebaceous gland limb hypertrophy in hair follicle, makes the sebaceous gland drainage difficulty, hair follicle sebum catheter opening stops up, and forms the infringement of acne and pimple.Hypersteatosis and drainage difficulty easily cause the infection of corynebacterium acnes etc., red inflammation pimple, pustule and tuberosity cyst occur.In addition, cosmetics, medicine, being in the air conditioner surroundings that the cold and hot temperature difference is larger for a long time, is also the acne risk factor.
The primary disease skin lesion mainly occurs in face, is secondly thoracic dorsal top and shoulder, also occurs in once in a while other positions, and how all skin of socket of the eye does not involve.The initial stage great majority have blackhead and seborrhea adiposa to go out, then pimple, tuberosity, pustule or cyst, sinus tract, cicatrix.The big or small depth of various infringements does not wait, and often take one or two kind of infringement as main.When inflammation is obvious, can cause pain or tenderness.According to erythra form and state of an illness weight, generally be divided into pimple acne type, pustule type, nodositas, cyst, five kinds of forms of aggretion type.
The treatment that is directed at present acne adopt more antibiotic, retinoid, gonadal hormone and contraceptive and and suppress the Drug therapy of sebaceous gland function, but all exist certain side effect, as retinoid, though can effectively suppress smegma, the side effect such as its mucocutaneous drying had and teratogenesis clinically can not be ignored.
Summary of the invention
For above-mentioned situation, to overcome the defect of prior art, purpose of the present invention, be to provide a kind of easy to use, determined curative effect, scientific formulation is simple, the scope of application is wide, treatment time is short, the Chinese medicine for outer use of a kind of Acne treatment prepared by the Chinese crude drug had no side effect.This invention to light, in, the various types of acne cure rates of severe can reach more than 93%.
The present invention is achieved in that
Medicine of the present invention is prepared from by the raw material of following components by weight percent: Indigo Naturalis 10-20, Fructus Kochiae 15-25, Radix Et Rhizoma Rhei 15-25, Folium Isatidis 20-25, Rhizoma Atractylodis 15-25,, Fructus Evodiae 15-20, linum 10-20, Radix Angelicae Sinensis 15-25, Radix Glycyrrhizae 15-25, Radix Sanguisorbae 25-40, Herba Artemisiae Scopariae 25-45, Herba Hedyotidis Diffusae 30-40, Olibanum 15-25, Sanguis Draxonis 15-25, Radix Stemonae 20-30, Galla Chinensis 15-25, Cortex Dictamni 10-20, Myrrha 15-25, Radix Angelicae Dahuricae 15-25, Radix Salviae Miltiorrhizae 15-25, Radix Paeoniae Rubra 20-25, Radix Isatidis 15-25, Flos Carthami 15-25.
Medicine of the present invention preferred version by weight ratio is:
Indigo Naturalis 15, the Fructus Kochiae 15, Radix Et Rhizoma Rhei 20, Folium Isatidis 20, Rhizoma Atractylodis 20, Fructus Evodiae 15, linum root 15, Radix Angelicae Sinensis 20, Radix Glycyrrhizae 20, Radix Sanguisorbae 30, Herba Artemisiae Scopariae 30, Herba Hedyotidis Diffusae 30, Olibanum 15, Sanguis Draxonis 20, the Radix Stemonae 25, Galla Chinensis 20, Cortex Dictamni 15, Myrrha 15, the Radix Angelicae Dahuricae 15, Radix Salviae Miltiorrhizae 20, Radix Paeoniae Rubra 15, Radix Isatidis 15, Flos Carthami 15.
External preparation of the present invention is produced simply, and wherein a kind of simple and easy to do method is comprised of following steps:
(1) by proportioning, take the dried feed medicine, pulverize respectively, and cross the 100-120 mesh sieve;
(2) the gained material powder is evenly mixed;
(3) will mix gained crude drug powder and add the immersion of 500ml jowar wine;
(4) soak rear the stirring one week of immersion of two weeks;
(5) stirring will be soaked gained extraction filtration after soaking a week, make medicinal liquid.
The selected crude drug modern pharmacological research of the present invention proves:
Indigo Naturalis: nature and flavor are salty, cold.Has heat-clearing and toxic substances removing, removing heat from blood, the effect of arresting convulsion and maculae caused by violent heat pathogen.
The Fructus Kochiae: nature and flavor are hot, bitter, cold.Has clearing away heat-damp and promoting diuresis, the effect of dispelling wind for relieving itching.
Radix Et Rhizoma Rhei: the nature and flavor hardship, cold.Has removing pathogenic heat from blood and toxic substance from the body, the effect of eliminating blood stasis and inducing menstruation ， Po lumps in the chest and abdomen.
Folium Isatidis: the nature and flavor hardship, cold.Has heat-clearing and toxic substances removing, the effect of blood cooling and ecchymoses removing.
Rhizoma Atractylodis: nature and flavor suffering, hardship, temperature.Having invigorates blood circulation preserves youthful looks, dampness, the effect of expelling wind and cold.
Fructus Evodiae: nature and flavor suffering, hardship, heat.Have warming middle-JIAO, pain relieving, regulate the flow of vital energy, the effect of dampness.
The linum root: the nature and flavor suffering, sweet, flat.Have tonify deficiency, invigorate blood circulation, strongly invigorating primordial QI, the effect of blood activating and promoting tissue regeneration.
Radix Angelicae Sinensis: nature and flavor sweet, acrid, warm.Have broken stagnant blood, support fresh blood Ji the effect of Zhu Disorder addiction.External can be accelerated wound healing, and contrafluxion, leukocyte and fiber are infiltrated, and newborn epithelium regeneration has the effect of hemostasis and reinforcement peripheral circulation to local organization.
Radix Glycyrrhizae: nature and flavor are sweet, flat.Have heat-clearing and toxic substances removing, relieving spasm to stop pain, suppress ulcer function, antiinflammatory, antiallergic action and Detoxication.
Radix Sanguisorbae: the nature and flavor hardship, flat.Have except migratory arthralgia, cooling blood for hemostasis, the removing toxic substances sore, separate the effect of all pyretic toxicity carbuncles.
Herba Artemisiae Scopariae: nature and flavor are bitter, hot, are slightly cold.Has the effect except rheumatism cold and heat pathogen.
Herba Hedyotidis Diffusae: nature and flavor are sweet, light, cool.Have heat-clearing and toxic substances removing, the effect of promoting blood circulation and stopping pain, can treat furuncle toxic swelling disease.
Olibanum: nature and flavor suffering, hardship, temperature.Have promoting blood circulation and stopping pain, change sore, carbuncle and painful swelling, the effect of detumescence and promoting granulation.
Sanguis Draxonis: nature and flavor are sweet, salty, flat.Has removing blood stasis and relieving pain, the effect of hemostasia and promoting granulation.
The Radix Stemonae: nature and flavor are sweet, bitter, tepor.Effect with killing parasites for relieving itching.
Galla Chinensis: nature and flavor acid, puckery, cold.Has the arresting sweating hemostasis, the effect of removing dampness sore.For traumatic hemorrhage
, carbuncle sore tumefacting virus, the Skin wet and rotten effect is remarkable.
Cortex Dictamni: the nature and flavor hardship, cold.Has heat clearing and damp drying, the effect of the removing toxic substances of dispeling the wind.
Myrrha: the nature and flavor hardship, flat.Has eliminating stasis to stop pain, the effect of detumescence and promoting granulation.
The Radix Angelicae Dahuricae: nature and flavor suffering, temperature.Has loose wind dehumidifying, understand things pain-stopping, the effect of detumescence and apocenosis.
Radix Salviae Miltiorrhizae: nature and flavor hardship, tepor.Has promoting blood circulation to remove blood stasis, the effect of sedation-analgesia.
Radix Paeoniae Rubra: the nature and flavor hardship is slightly cold.Has clearing away heat and cooling blood, the effect of eliminating stasis to stop pain.
Flos Carthami: nature and flavor suffering, temperature.Has promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, the effect that removing dampness is antipruritic.
Advantage of the present invention is: the present invention has the effect of heat-clearing and toxic substances removing, dispelling wind for relieving itching, blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating stagnation simultaneously, has the local microcirculation of improvement, promotes metabolism and the absorption of inflammation, and the removing dampness sore, kill the specific treatment effect of propionibacterium acnes.For the inflammatory pimple that acne occurs, papulovesicle, tuberosity.Abscess cyst, and the pigmentation left after the acne healing.And the present invention can make the through sick institute of medicine and play effectiveness, and has reduced the first pass effect of liver, pure Chinese medicinal preparation, safe without toxic side effect.
The specific embodiment
Embodiment 1:
Get Indigo Naturalis 15g, Fructus Kochiae 15g, Radix Et Rhizoma Rhei 20g, Folium Isatidis 20g, Rhizoma Atractylodis 20g, Fructus Evodiae 15g, linum root 15g, Radix Angelicae Sinensis 20g, Radix Glycyrrhizae 20g, Radix Sanguisorbae 30g, Herba Artemisiae Scopariae 30g, Herba Hedyotidis Diffusae 30g, Olibanum 15g, Sanguis Draxonis 20g, Radix Stemonae 25g, Galla Chinensis 20g, Cortex Dictamni 15g, Myrrha 15g, Radix Angelicae Dahuricae 15g, Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra 15g, Radix Isatidis 15g, Flos Carthami 15g.
By above all medicine crushed after being dried, cross the 100-120 mesh sieve, after will the gained material powder evenly mixing, add the 500ml jowar wine and soak after two weeks to stir and soak weeks, stir to soak after a week and will soak gained and extract filtration, make medicinal liquid.Each once dips liquid medicine painting in the acne place with cotton swab to the gained medicinal liquid with morning, noon and afternoon every day, and surrounding is a course for the treatment of.
Embodiment 2:
Get Indigo Naturalis 20g, Fructus Kochiae 15g, Radix Et Rhizoma Rhei 20g, Folium Isatidis 15g, Rhizoma Atractylodis 15g, Fructus Evodiae 20g, linum root 15g, Radix Angelicae Sinensis 20g, Radix Glycyrrhizae 20g, Radix Sanguisorbae 25g, Herba Artemisiae Scopariae 25g, Herba Hedyotidis Diffusae 40g, Olibanum 20g, Sanguis Draxonis 15g, Radix Stemonae 20g, Galla Chinensis 25g, Cortex Dictamni 10g, Myrrha 20g, Radix Angelicae Dahuricae 20g, Radix Salviae Miltiorrhizae 15g, Radix Paeoniae Rubra 20g, Radix Isatidis 15g, Flos Carthami 15g.
By above all medicine crushed after being dried, cross the 100-120 mesh sieve, after will the gained material powder evenly mixing, add the 500ml jowar wine and soak after two weeks to stir and soak weeks, stir to soak after a week and will soak gained and extract filtration, make medicinal liquid.The gained medicinal liquid with morning, noon and afternoon every day each once, with cotton swab, dip liquid medicine painting in the acne place, surrounding is a course for the treatment of.
Clinical trial
The therapeutic effect of medicine of the present invention to acne, can observe and further be confirmed by following clinical case:
1, clinical data
(1) test altogether patients with acne 100 examples, male patient's 36 examples wherein, female patient 64 examples, age is at 16-35 between year, all cases all meets the diagnostic criteria (be apt to occur in other oils and fats glands such as face and trunk top and enrich position, pimple acne type, pustule type, nodositas, cyst, the infringement of aggretion type multirow are arranged) of " acne ".
(2) above-mentioned patient is divided into to two groups at random:
First group is treatment group, totally 50 examples, female's 33 examples wherein, male 17 examples, 26.5 years old mean age.
Second group is matched group, totally 50 examples, female's 31 examples wherein, male 19 examples, 25.8 years old mean age.
2, Therapeutic Method
Treatment group external medicine of the present invention, morning, noon and afternoon every day respectively once, dip liquid medicine painting in the acne place with cotton swab, and two weeks were a course for the treatment of.
Matched group adopts oral antibiotic (as tetracycline, erythromycin), retinoid, local topical adapalene, 5% chlorine willow tincture, and surrounding is a course for the treatment of.
3, curative effect determinate standard
Cure: skin lesion disappears fully, and subjective symptoms disappears.
Effectively: subjective symptoms obviously alleviates, and skin lesion disappears and is greater than 30%.
Invalid: skin lesion and symptom be the unchanged or less than 30% that disappears all.
4, efficacy result sees the following form:
5, conclusion
Visible by above contrast test: the present invention is for the acne treatment successful, and cure rate and total effective rate be higher than other drug, and have easy to use, the characteristics of safe without toxic side effect.
Concrete case
1, Huang, the female, 19 years old, the high school senior, Liaocheng of Shandong Province people from Yanggu County, suffered from more than cyst type acne half a year, isotretinoin capsule for oral administration once, the invalid here afterwards of external adapalene gel is medical, and after this medicine of external, three weeks cured.
[0049] 2, give birth to certain, the man, 28 years old, workman, Liaocheng of Shandong Province people from urban district, cyst type mixing acne nodosum more than 1 year, involve face and cervical region, patient's readme is metronidazole for oral administration once, the topical Retinoids emulsifiable paste, in local medical institutions, failing to respond to any medical treatment, here was medical afterwards, and after this medicine of external, surrounding is cured.
Claims (2)
1. the Chinese medicinal liniment of an Acne treatment, is characterized in that the raw material composition of making effective ingredient is by weight ratio: Indigo Naturalis 10-20, Fructus Kochiae 15-25, Radix Et Rhizoma Rhei 15-25, Folium Isatidis 20-25, Rhizoma Atractylodis 15-25,, Fructus Evodiae 15-20, linum 10-20, Radix Angelicae Sinensis 15-25, Radix Glycyrrhizae 15-25, Radix Sanguisorbae 25-40, Herba Artemisiae Scopariae 25-45, Herba Hedyotidis Diffusae 30-40, Olibanum 15-25, Sanguis Draxonis 15-25, Radix Stemonae 20-30, Galla Chinensis 15-25, Cortex Dictamni 10-20, Myrrha 15-25, Radix Angelicae Dahuricae 15-25, Radix Salviae Miltiorrhizae 15-25, Radix Paeoniae Rubra 20-25, Radix Isatidis 15-25, Flos Carthami 15-25.
2. the Chinese medicinal liniment of a kind of Acne treatment according to claim 1, is characterized in that raw material composition and the weight proportion of making effective ingredient are: Indigo Naturalis 15, the Fructus Kochiae 15, Radix Et Rhizoma Rhei 20, Folium Isatidis 20, Rhizoma Atractylodis 20, Fructus Evodiae 15, linum root 15, Radix Angelicae Sinensis 20, Radix Glycyrrhizae 20, Radix Sanguisorbae 30, Herba Artemisiae Scopariae 30, Herba Hedyotidis Diffusae 30, Olibanum 15, Sanguis Draxonis 20, the Radix Stemonae 25, Galla Chinensis 20, Cortex Dictamni 15, Myrrha 15, the Radix Angelicae Dahuricae 15, Radix Salviae Miltiorrhizae 20, Radix Paeoniae Rubra 15, Radix Isatidis 15, Flos Carthami 15.
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| CN103623311A (en) * | 2013-11-29 | 2014-03-12 | 青岛中科菲力工程技术研发有限公司 | Traditional Chinese medicinal composition for treating eczema scroti |
| CN103908558A (en) * | 2014-04-22 | 2014-07-09 | 福州永同惠生物医药科技有限公司 | Traditional Chinese medicine composition for treating acne and preparation method and application thereof |
| CN108114115A (en) * | 2018-02-02 | 2018-06-05 | 陆俊捷 | A kind of emulsifiable paste for being used for acne and skin barrier injury repair and its preparation method and application |
| CN108524422A (en) * | 2018-06-13 | 2018-09-14 | 刘洪印 | A kind of Chinese medicine toxin expelling Deacne pack and preparation method thereof |
| CN112618649A (en) * | 2021-01-06 | 2021-04-09 | 陈祥 | Yao medicine for treating acne and preparation method thereof |
| CN116077388A (en) * | 2022-11-29 | 2023-05-09 | 山东禾宝药业有限公司 | Acne-removing Chinese herbal medicine composition and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103623311A (en) * | 2013-11-29 | 2014-03-12 | 青岛中科菲力工程技术研发有限公司 | Traditional Chinese medicinal composition for treating eczema scroti |
| CN103908558A (en) * | 2014-04-22 | 2014-07-09 | 福州永同惠生物医药科技有限公司 | Traditional Chinese medicine composition for treating acne and preparation method and application thereof |
| CN108114115A (en) * | 2018-02-02 | 2018-06-05 | 陆俊捷 | A kind of emulsifiable paste for being used for acne and skin barrier injury repair and its preparation method and application |
| CN108524422A (en) * | 2018-06-13 | 2018-09-14 | 刘洪印 | A kind of Chinese medicine toxin expelling Deacne pack and preparation method thereof |
| CN115463178A (en) * | 2018-06-13 | 2022-12-13 | 刘洪印 | Traditional Chinese medicine composition for expelling toxin and removing acne and preparation method and application thereof |
| CN112618649A (en) * | 2021-01-06 | 2021-04-09 | 陈祥 | Yao medicine for treating acne and preparation method thereof |
| CN116077388A (en) * | 2022-11-29 | 2023-05-09 | 山东禾宝药业有限公司 | Acne-removing Chinese herbal medicine composition and preparation method and application thereof |
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