CN108114115A

CN108114115A - A kind of emulsifiable paste for being used for acne and skin barrier injury repair and its preparation method and application

Info

Publication number: CN108114115A
Application number: CN201810108054.8A
Authority: CN
Inventors: 陆俊捷; 李国娜; 张成波; 叶翔宇
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-02-02
Filing date: 2018-02-02
Publication date: 2018-06-05

Abstract

The present invention relates to a kind of emulsifiable pastes for acne and skin barrier injury repair, include the raw material that following parts by weight match：12~15 parts of oldenlandia diffusa, 12~15 parts of climbing groundsel, 12~15 parts of Chinese holly, 12~15 parts of Chinese violet, 8~10 parts of felwort, 8~10 parts of the root bark of shaggy-fruited dittany, 8~10 parts of barberry, 6~8 parts of Eucalyptus globulus Labill leaf, 6~8 parts of peppermint, 10~12 parts of loguat leaf, 8~10 parts of rhizoma atractylodis, 6~8 parts of piper cubeba, 6~8 parts of eclipta, 6~8 parts of Herba Cistanches, 10~12 parts of Radix Paeoniae Alba, 8~10 parts of bush, 8~10 parts of dragon's blood, 8~10 parts of catechu.Above-mentioned raw materials are extracted, filter, are prepared by mixing into emulsifiable paste with auxiliary material after alcohol precipitation, are applied as Retinoids, Retin-A, Renova, Accutane, can treat both principal and secondary aspect of disease, pay attention to prognosis, prevent from recurring.

Description

It is a kind of for emulsifiable paste of acne and skin barrier injury repair and preparation method thereof and Using

Technical field

The present invention relates to traditional Chinese medicine for outer use technical fields, are repaiied more particularly to one kind for acne and skin barrier damage Multiple emulsifiable paste and its preparation method and application.

Background technology

Acne is the common disease of Dermatology Outpatient Department, and skin lesion shows as pinhead-sized hair follicle sample papule, can be with redness The inflammation performance of hot pain, the sebum content of visible granulated slag sample after extruding have certain self limiting.Western medicine think this disease with Endocrine, pilosebaceous duct angling, infection, immune and inherent cause are related.This disease incidence is higher, in puberty men and women In more so.Since this disease influences beauty, therefore patient often voluntarily squeezes or scratches papule, causes secondary skin lesion, and forms skin Barrier is damaged, and performance includes local hemorrhage, ulcer formation, general red, swelling, itch etc.；If accumulative skin corium, can form after healing Scar, influences patient's beauty, and harm is larger.

In Surgery of Chinese Medicine, the etiology and pathogenesis of acne can be summarized as wind and heat in the lung meridian and fumigate face；Overfeeding delicious food, stomach are wet Heat, upper steaming face；Deficiency of spleen-QI, dysfunction of the spleen in transportation and transformation, it is wet it is turbid in stop, strongly fragrant longization heat, the bright body fluid of heat, into phlegm, the phlegm wet stasis of blood is stagnant to coagulate refining liquid Stagnant skin.Shi Re Bing Pian condensation face is for mark, symptomatic treatment in acute condition in this disease；At all hot and suffocating for lung channel, the wet turbid tired spleen of disease, kidney Asthenic yin and flaring up of deficient fire；Local qi and blood stagnation after being ill, forms patch, and blood-deficiency and wind-dry is sent out as itch or even acne print.

The prior art has local topical drug, oral antibiotic, oral isotretinoin, anti-hero for the therapy of acne Hormone therapy, oral glucocorticoid, laser therapy etc..Wherein local topical drug include tretinoin, benzoyl peroxide, Antibiotics (clindamycin, erythromycin, chloramphenicol etc.), azelaic acid, sulphur lotion etc.；Oral antibiotic include Tetracyclines, Macrolides；Anti-androgen therapy such as oral contraceptive Compound Cyproterone Acetate Tablets.Tretinoin medicines can accelerate epidermis Cutin comes off, and has certain irritation, and long-term a large amount of uses can make keratoderma too thin and cause allergy and then induce more More skin problems.Benzoyl peroxide can cause some patientss shouting pain, itch occur, tighten sense and burn feeling, erythema, water occur Swollen, dry and furfur adverse reaction.Clindamycin can cause the allergic reactions such as dry skin, local excitation, fash, and part Patient is present with the situation of acne recurrence after deactivated.Erythromycin, chloramphenicol, azelaic acid, the external application of sulphur lotion mainly play The effect of its antibacterial anti-inflammatory for acne caused by internal cause, is also possible to cause recurrence after deactivated.Oral tetracycline antibiotic Gastrointestinal reaction, hepatic lesion, hypovitaminosis, renal toxicity can be caused, and have irreversible influence to bone, tooth growth, do not applied to In adolescent acne patient's long-time service.Oral macrolide antibiotics can cause enteron aisle reaction, hepatic lesion, allergy, Cardiac toxic and hematotoxicity.Oral contraceptive significantly affects the generation of body hormone, is unsuitable for male, and can cause patient Occur breast tenderness, pain, secretion, have a headache, be in a very depressed state, do not tolerate contact lenses, Nausea and vomiting, vaginal fluid change, Various skin diseases, fluid retention, weight gain, allergic reaction, dysfunction of liver, serum triglyceride rise.Sugared cortical hormone Element can cause water, salt, sugar, protein and fat metabolic disturbance, and weaken Abwehrkraft des Koepers, hinder tissue repair, delay tissue Healing inhibits upgrowth and development of children, and heavy dose should not be pregnant using glucocorticoid person.Laser therapy has certain wound Property, and the root problem of endogenous acne cannot be solved.Above for acne the prior art there are certain side effect and It cannot solve the problems, such as the internal cause of acne, the possibility that there is recurrence after stopping.

The content of the invention

For certain side effect exists in the prior art and cannot solve the problems, such as the internal cause of acne, stop after existing it is multiple The problem of possibility of hair, the present invention provide a kind of emulsifiable paste for acne and skin barrier injury repair.

And the present invention also provides a kind of preparation methods for the emulsifiable paste for being used for acne and skin barrier injury repair.

And acne drug neck is being prepared for the emulsifiable paste of acne and skin barrier injury repair the present invention also provides a kind of The application in domain.

To achieve the above object of the invention, the embodiment of the present invention employs following technical solution：

A kind of emulsifiable paste for acne and skin barrier injury repair includes the raw material of following parts by weight proportioning：White flower 12~15 parts of HERBA HEDYOTIS DIFFUSAE, 12~15 parts of climbing groundsel, 12~15 parts of Chinese holly, 12~15 parts of Chinese violet, 8~10 parts of felwort, 8~10 parts of the root bark of shaggy-fruited dittany, 8~10 parts of barberry, 6~8 parts of Eucalyptus globulus Labill leaf, 6~8 parts of peppermint, 10~12 parts of loguat leaf, rhizoma atractylodis 8~10 Part, 6~8 parts of piper cubeba, 6~8 parts of eclipta, 6~8 parts of Herba Cistanches, 10~12 parts of Radix Paeoniae Alba, 8~10 parts of bush, dragon's blood 8~10 Part, 8~10 parts of catechu.

It is provided by the present invention for the emulsifiable paste of acne and skin barrier injury repair synthesis sample compared with the prior art With prognosis, clearing away heat-damp and expelling toxic material controls its mark suddenly, and prognosis is paid attention in three dirty slow Zhi Qiben of reconciliation lung spleen kidney, nourshing blood and promoting blood circulation, and fever and chills match, Combined into side, the benefits of playing clearing heat and detoxicating sore, clearing damp dispelling wind, clearing lung-heat eliminating dampness, YIN and YANG balance regulating altogether, antibiosis in the prior art is avoided The side effect that element, chemicals are brought, solves the internal cause of acne, and avoids recurring.

And the embodiment of the present invention additionally provides a kind of system of above-mentioned emulsifiable paste for being used for acne and skin barrier injury repair Preparation Method, the emulsifiable paste for acne and skin barrier injury repair is by raw material is extracted, filtering, is mixed with auxiliary material after alcohol precipitation It is prepared.

The preparation method improves the bioavilability of active ingredient in raw material, is allowed to be more readily absorbed and plays effect Fruit is made after emulsifiable paste and is easy to use, and can by emulsifiable paste the features such as ductility is good, easy infiltration, promote in raw material effectively into Divide and play a role.

The embodiment of the present invention also provides the above-mentioned emulsifiable paste for being used for acne and skin barrier injury repair in preparation acne drug The application in field.

Emulsifiable paste provided by the present invention for treat acne when, raw material therein can complex treatment sample pay attention to again in advance Afterwards, avoid recurring, and manufactured emulsifiable paste can also aid in the effect for playing active ingredient in raw material, and make convenient for patients with acne With so as to preferably play the role for the treatment of acne and repair skin barrier.

Description of the drawings

Fig. 1 is the experiment skin progress pathological section figure that mouse is normally organized in zoopery；

Fig. 2 is that the experiment skin of model group mouse in zoopery carries out pathological section figure；

Fig. 3 is that the experiment skin of 1 group of mouse of embodiment in zoopery carries out pathological section figure；

Fig. 4 is that the experiment skin of 3 groups of mouse of embodiment in zoopery carries out pathological section figure；

Fig. 5 is that the experiment skin of positive control group mice in zoopery carries out pathological section figure.

Specific embodiment

In order to make the purpose , technical scheme and advantage of the present invention be clearer, below in conjunction with specific embodiment, to this Invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, not For limiting the present invention.

The embodiment of the present invention provides a kind of emulsifiable paste for acne and skin barrier injury repair, including following parts by weight The raw material of proportioning：12~15 parts of oldenlandia diffusa, 12~15 parts of climbing groundsel, 12~15 parts of Chinese holly, 12~15 parts of Chinese violet, 8~10 parts of felwort, 8~10 parts of the root bark of shaggy-fruited dittany, 8~10 parts of barberry, 6~8 parts of Eucalyptus globulus Labill leaf, 6~8 parts of peppermint, loguat leaf 10~ 12 parts, 8~10 parts of rhizoma atractylodis, 6~8 parts of piper cubeba, 6~8 parts of eclipta, 6~8 parts of Herba Cistanches, 10~12 parts of Radix Paeoniae Alba, bush 8~ 10 parts, 8~10 parts of dragon's blood, 8~10 parts of catechu.

During pathogenesis of acne, skin lesion red and swollen heat pain, for fear of beauty has single generation, also there is comprehensive general hair, patient is often anxious Irritated, worried anxiety or even frustration close family plug window, therefore alleviate skin lesion, and it is anxious for mark to repair skin barrier.In the present invention Oldenlandia diffusa is cold in nature, bitter, sweet, returns stomach, large intestine, small intestinl channel, clearing heat and detoxicating, dampness removing is treating stranguria, available for carbuncle sore tumefacting virus；A thousand li Photosensitiveness is trembled with fear, bitter, return lung, Liver Channel, and clear thermolysin clears liver and improve vision, removing dampness through diuresis and relieving itching, and the carbuncle swells sore that using fresh herb can control heat toxin heap soil or fertilizer over and around the roots knot is itched； Chinese holly is cool in nature, bitter, puckery, return lung, large intestine, bladder warp, clearing heat and detoxicating, myogenic sore, cooling blood and hemostasis；Chinese violet is cold in nature, Bitter, pungent, converge to heart and liver channels, clearing heat and detoxicating, cool blood detumescence.Oldenlandia diffusa, climbing groundsel, Chinese holly are clearing heat and detoxicating, Chinese violet Four medicine bitter colds are cool to rush down, and is all monarch drug in a prescription, controls the mark that heat toxin stops up Sheng.

The acne state of an illness is touching, and delay is refractory, is for caused by damp evil.Felwort is cold in nature, bitter, Return liver, gallbladder channel, and heat-clearing is dry Wet, purging the liver of pathogenic fire courage fire has antibacterial and anti-inflammatory effect, can inhibit the inflammatory reaction that acne propionic acid feels mediation；The root bark of shaggy-fruited dittany is cold in nature, Bitter, returns spleen, stomach, bladder warp, heat-clearing and damp-drying drug, detoxifying and relieving itching are outstanding kind except skin is damp and hot；Barberry is cold in nature, bitter, Return liver, stomach, Large intestine channel, heat-clearing and damp-drying drug, purging intense heat and detonicating can treat heat toxin sore carbuncle.Felwort, the root bark of shaggy-fruited dittany, barberry are all ministerial drug, wash away middle coke It is damp and hot, break off the source of damp and hot upper steaming, the clearing heat and detoxicating work(of principal drug assistance.

Acne hair closes skin in face skin, lung five body constituents.Eucalyptus globulus Labill leaf is cold in nature, bitter, pungent, return lung, stomach, spleen, Liver Channel, dispelling wind solution Table, clearing heat and detoxicating, desinsection is antipruritic, can treat ulcerative carbuncle pyogenic infections, eczema mange；Peppermint is cool in nature, acrid flavour, return lung, Liver Channel, life evacuation Wind-heat, refresh oneself, throat, promoting eruption is antipruritic, soothing liver-qi stagnation.Eucalyptus globulus Labill leaf and peppermint gently rise clearly floating, take all drug effect power and go directly lung channel, It is to make medicine.

Acne sheet is wind and heat in the lung meridian, and damp-heat retention in spleen is fire excess from yin deficiency, if controlling its mark on foot, probably stays illness, sitting and lying daily life, sweating Work as wind, Exogenous and internal injuries, addiction to greasy and sweet foods, and can fall ill, doctor is unexamined basic, and increasing is worried on foot for sufferer, therefore we and the root for paying attention to disease This prevention adjusts three dirty function of lung spleen kidney.Loguat leaf cold nature, bitter attach to the lung and stomach meridians, can removing heat from the lung to relieve cough, evacuate lung wind Heat has anti-inflammatory effect, can mitigate the inflammatory reaction during pathogenesis of acne, reduce the generation of skin lesion, be for ministerial drug.

The cold and cool medicine in full side is exaggerated, and probably consumes impairment of the spleen sun, and spleen sun is not transported, phlegm wet condensation, not only phlegm wet condenses, more probably it is cold and cool it Product, which are upset one's stomach, to be impairment of the kidney, therefore selects rhizoma atractylodis, piper cubeba with warming spleen and stomach for dispelling cold, drying damp and strengthening spleen.Rhizoma atractylodis are warm-natured, acrid flavour, hardship, returns spleen, stomach, Liver Channel, It is drying damp and strengthening spleen, expelling wind and clearing away cold；Piper cubeba is warm-natured, acrid flavour, returns spleen, stomach, kidney, bladder warp, warming spleen and stomach for dispelling cold, promoting qi circulation and relieving pain.Rhizoma atractylodis, Bi Clear eggplant restricts the bitter cold pharmacological property of the medicine of the monarch and his subjects jointly, and can temperature sun and help the transporting of spleen, temper is good for fortune, and damp evil solves then, and patient's condition obtains It is good.In addition, rhizoma atractylodis have hepatoprotective effect, in the present invention with rhizoma atractylodis, the hepatic injury as caused by Chinese medicine is possible can be prevented, together When also have synergistic effect with felwort, enhance its antibacterial bacteriostatic effect.

Eclipta is cold in nature, sweet in flavor, sour, returns liver and kidney channel, nourishing kidney-yin, cooling blood and hemostasis；Herba Cistanches are warm-natured, sweet in flavor, salty, return kidney, Large intestine channel, kidney-replenishing, benefiting essence-blood.Eclipta and Herba Cistanches negative and positive and tune restrict the flaring up of deficient fire of the deficiency of the kidney yin, be for adjutant, By the adjusting to kidney, realize the adjusting to hypothalamic-pituitary-adrenal (sexual gland/thyroid gland) axis, avoid the big of male sex hormone Amount discharges and stimulates a large amount of sebum secreteds of sebaceous glands, achievees the purpose that reduce pathogenesis of acne.Herba Cistanches also have strengthen immunity Effect, in we, it is possible to reduce a large amount of multiplication of patient's propionibacterium acnes safeguard the balance of skin surface flora.

Acne has certain self limiting, but may result in skin corium due to the improper extruding of patient in pathogenic process It is damaged and healing cicatrization occurs, therefore during treatment, it should pay attention to the reparation of skin barrier.The skin barrier of narrow sense is usually Refer to epidermis, particularly the mechanical barrier structure of cuticula.Mechanical barrier is directly contacted with the external world, is had to extraneous various damages The protective action of wound, while also have the integrality for maintaining skin, prevent internal epidermis and the substances such as intradermal moisture and lipid from losing The function of mistake.During pathogenesis of acne, skin barrier structural proteins, lipidosis cause skin barrier function by Damage, can lead acnegenic recurrent exerbation, further aggravate the damage of skin barrier.Bush is mild-natured, sweet in flavor, salty, pungent, the thoughts of returning home, Liver Channel, promoting blood circulation, swelling and pain relieving；Dragon's blood is mild-natured, sweet in flavor, salty, converge to heart and liver channels, analgesic therapy of invigorating blood circulation, removing blood stasis and hemostasis, myogenic sore, With anti-inflammatory pain-stopping effect, the infection of ulcer surface can be prevented；Catechu cold nature, bitter, puckery, distributed in heart and lung channels, promoting blood circulation and stopping pain, only Blood myogenic, hygroscopic sore are controlled sore and are not held back, can be with dragon's blood with use.Bush, dragon's blood, catechu synergistic effect can promoting blood circulation and removing blood stasis, detumescences Analgesic therapy, myogenic sore, treatment carbuncle sore tumefacting virus.In addition, the anti-inflammatory pain-stopping effect of dragon's blood can act synergistically with felwort, rhizoma atractylodis, increase The effect of strong resisting pathogenic microbes.Radix Paeoniae Alba nourishing blood for regulating menstruation, the analgesic of soft liver, in morbidity and pre- later stage, patient often feels pruitus, Migration is indefinite, spins up rotation and goes out, is haunted for ailment said due to cold or exposure, and Radix Paeoniae Alba takes the meaning of " control wind and first control blood, blood wind goes out certainly ", and nourshing blood and promoting blood circulation stops Itch analgesic therapy；Radix Paeoniae Alba has the soothing the liver effect of soft liver concurrently, can the anxiety that is generated due to the state of an illness of reduction of patient.

To sum up, we are clearing heat and detoxicating, can suddenly take stopgap measures, clearing lung-heat temperature spleen, YIN and YANG balance regulating, radical treatment in chronic case, repair skin barrier, weight Depending on prognosis, prevent from recurring.

It is further preferred that the felwort, the root bark of shaggy-fruited dittany, barberry, loguat leaf, rhizoma atractylodis, piper cubeba, eclipta, meat desert Rong, bush, dragon's blood, catechu are the medicinal material after processing, the oldenlandia diffusa, climbing groundsel, Chinese holly, Chinese violet, blue gum Leaf, peppermint, Radix Paeoniae Alba are the fresh medicine material not processed after cleaning.Due to oldenlandia diffusa, climbing groundsel, Chinese holly, Chinese violet, Eucalyptus globulus Labill leaf, peppermint, Radix Paeoniae Alba contain volatile component, can not high-temperature process, therefore using fresh herb.

It is further preferred that the rhizoma atractylodis are wheat bran rhizoma atractylodis, drying damp and strengthening spleen effect is stronger；The eclipta is eclipta Charcoal, convergence astringent method hemostasia effect is more preferably.

It is further preferred that the auxiliary material of following parts by weight proportioning is further included in formula：51~55 parts of distilled water, sorbierite 24~28 parts, 0.04~0.06 part of natrium adetate, 3.5~4.0 parts of propylene glycol, 7~9 parts of atoleine, PEG-30 dimerization hydroxyls 2.6~3.0 parts of base stearate, single 2.6~3.0 parts of glyceryl isostearate, 0.2~0.3 part of ethylparaben.Above-mentioned auxiliary material In, distilled water, sorbierite, natrium adetate, propylene glycol are water phase, can extract acquired solution with raw material and mix, atoleine, It is oil phase to be sustained emulsifier, single glyceryl isostearate, ethylparaben, and mutually w/o type lotion can be formed with water.

It is further preferred that include the auxiliary material of following parts by weight proportioning：53 parts of distilled water, 26 parts of sorbierite, edetic acid(EDTA) 0.05 part of disodium, 3.75 parts of propylene glycol, 8 parts of atoleine, 2.8 parts of PEG-30 dimerization hydroxy stearic acid ester, single isostearic acid is sweet 2.8 parts of grease, 0.25 part of ethylparaben.

It is further preferred that the sustained release emulsifier is included for PEG-30 dimerization hydroxy stearic acid ester, sesquialter oleic acid sorb At least one of smooth, poloxamer.Three kinds of emulsifiers can the water oil interface of lotion formed membranaceous material, and incite somebody to action Including drug tight among phase, so as to achieve the effect that sustained release.

The embodiment of the present invention also provides a kind of preparation method for the emulsifiable paste for being used for acne and skin barrier injury repair, described For the emulsifiable paste of acne and skin barrier injury repair by the raw material is extracted, filtering, mixes system with the auxiliary material after alcohol precipitation It is standby to form.

The preparation method process greatly improves the bioavilability of active ingredient in raw material, more by abstraction process It is easy to absorb and play effect；By the content for concentrating to reduce solvent in extracting solution, it is possible to reduce ethyl alcohol during alcohol precipitation uses Amount；Water-insoluble impurity is removed by alcohol precipitation；It is easy to use by being prepared by mixing into emulsifiable paste with auxiliary material, and can be by emulsifiable paste The features such as ductility is good, easy infiltration, active ingredient in raw material is promoted to play a role.Specifically, the step is：

Step a, each raw material is weighed by above-mentioned raw materials proportioning, by felwort, the root bark of shaggy-fruited dittany, barberry, loguat leaf, rhizoma atractylodis, Bi Clear eggplant, eclipta, Herba Cistanches, bush, dragon's blood, catechu add the water of 7~10 times of the material quality to decoct 40~50 minutes, add in Oldenlandia diffusa, climbing groundsel, Chinese violet, Chinese holly, Eucalyptus globulus Labill leaf, peppermint, Radix Paeoniae Alba continue decoction 10~20 minutes, filtering, to Add water to cook 1~2 time in filter residue, every time 1~1.5 it is small when, filtering merges all filtrates；

Step b, concentrate is obtained after filtrate is concentrated, adds in ethyl alcohol, stands, takes supernatant；

Step c, each auxiliary material is weighed by above-mentioned ratio of adjuvant, by distilled water, sorbierite, natrium adetate, propylene glycol and step Supernatant obtained by rapid b is uniformly mixed, and is heated to 90~95 DEG C and is kept the temperature preservation, obtains water phase；

Step d, atoleine, sustained release emulsifier, single glyceryl isostearate, ethylparaben are uniformly mixed, heated To 85~90 DEG C and preservation is kept the temperature, obtains oil phase；

Step e, the water is mutually added to the speed of 1~3 part/min under the mixing speed of 900~1100r/min In the oil phase, after stirring 20~25min, continue stirring to mixture temperature under the speed of 500~600r/min and be down to 20 ~30 DEG C to get.

Above-mentioned steps a by repeatedly decoct can decoct solution formed funneling effect, accelerate extract in effectively into The dissolution divided improves extraction efficiency.

To be concentrated under reduced pressure, the relative density for being concentrated into the concentrate is 1.10~1.20 for concentration described in above-mentioned steps b. Thickening efficiency can be improved using the method being concentrated under reduced pressure, shorten the operating time, the relative density of the concentrate after concentration is 1.10~1.20, it is possible to reduce ethanol consumption if liquid is excessively dilute, need to use substantial amounts of ethyl alcohol, so as to cause to waste, if overrich, It is present with a large amount of precipitation little Yi package active ingredients during alcohol precipitation, causes damages.

It is further preferred that concentration expressed in percentage by volume >=95% of the ethyl alcohol, the volume of the ethyl alcohol is the concentrate 1~1.5 times of volume, the time of the standing is 20~30h.After adding in ethyl alcohol and staticly settling, low molecule active ingredient It is still dissolved in dilute alcohol solution, and macromolecule impurity is then precipitated and stays in precipitation, so as to obtain refined supernatant.

In order to better illustrate embodiment of the present invention, illustrated below by embodiment is further.

Embodiment 1

An embodiment of the present invention provides a kind of emulsifiable paste for acne and skin barrier injury repair, including following parts by weight The raw material of number proportioning：12 parts of oldenlandia diffusa, 12 parts of climbing groundsel, 12 parts of Chinese holly, 12 parts of Chinese violet, 8 parts of felwort, shaggy-fruited dittany 8 parts of skin, 8 parts of barberry, 6 parts of Eucalyptus globulus Labill leaf, 6 parts of peppermint, 10 parts of loguat leaf, 8 parts of wheat bran rhizoma atractylodis, 6 parts of piper cubeba, eclipta charcoal 6 Part, 6 parts of Herba Cistanches, 10 parts of Radix Paeoniae Alba, 8 parts of bush, 8 parts of dragon's blood, 8 parts of catechu.

Further include the auxiliary material of following parts by weight proportioning：51 parts of distilled water, 24 parts of sorbierite, 0.04 part of natrium adetate, 3.5 parts of propylene glycol, 7 parts of atoleine, 2.6 parts of sustained release emulsifier (PEG-30 dimerization hydroxy stearic acid ester), single isostearic acid is sweet 2.6 parts of grease, 0.2 part of ethylparaben.

Preparation method：

Step a, each raw material is weighed by above-mentioned raw materials proportioning, felwort, the root bark of shaggy-fruited dittany, barberry, loguat leaf, wheat bran is grey Art, piper cubeba, eclipta charcoal, Herba Cistanches, bush, dragon's blood, catechu add the water of 7~10 times of the material quality to decoct 40~50 points Clock adds in oldenlandia diffusa, climbing groundsel, Chinese violet, Chinese holly, Eucalyptus globulus Labill leaf, peppermint, Radix Paeoniae Alba and continues decoction 10~20 minutes, Filtering, adds water to cook 1~2 time into filter residue, every time 1~1.5 it is small when, filtering merges all filtrates；

Step b, the concentrate that relative density is 1.10~1.20 is obtained after filtrate decompression is concentrated, addition is equivalent to concentrate The ethyl alcohol that 1~1.5 times of volume stands 20~30h, and filtering takes supernatant, crosses No. 5 sieves；

Embodiment 2

An embodiment of the present invention provides a kind of emulsifiable paste for acne and skin barrier injury repair, including following parts by weight The raw material of number proportioning：13.5 parts of oldenlandia diffusa, 13.5 parts of climbing groundsel, 13.5 parts of Chinese holly, 13.5 parts of Chinese violet, felwort 9 parts, 9 parts of the root bark of shaggy-fruited dittany, 9 parts of barberry, 7 parts of Eucalyptus globulus Labill leaf, 7 parts of peppermint, 11 parts of loguat leaf, 9 parts of wheat bran rhizoma atractylodis, 7 parts of piper cubeba, ink Non-irrigated 7 parts of lotus charcoal, 7 parts of Herba Cistanches, 11 parts of Radix Paeoniae Alba, 9 parts of bush, 9 parts of dragon's blood, 9 parts of catechu.

Further include the auxiliary material of following parts by weight proportioning：53 parts of distilled water, 26 parts of sorbierite, 0.05 part of natrium adetate, 3.75 parts of propylene glycol, 8 parts of atoleine, sustained release emulsifier (PEG-30 dimerization hydroxy stearic acid ester and Sorbitan Sesquioleate matter Amount is than being 1:1 mixture) 2.8 parts, single 2.8 parts of glyceryl isostearate, 0.25 part of ethylparaben.

Preparation method：

With embodiment 1.

Embodiment 3

An embodiment of the present invention provides a kind of emulsifiable paste for acne and skin barrier injury repair, including following parts by weight The raw material of number proportioning：It is 15 parts of oldenlandia diffusa, 15 parts of climbing groundsel, 15 parts of Chinese holly, 15 parts of Chinese violet, 10 parts of felwort, white 10 parts of fresh hide, 10 parts of barberry, 8 parts of Eucalyptus globulus Labill leaf, 8 parts of peppermint, 12 parts of loguat leaf, 10 parts of wheat bran rhizoma atractylodis, 8 parts of piper cubeba, ink drought 8 parts of lotus charcoal, 8 parts of Herba Cistanches, 12 parts of Radix Paeoniae Alba, 10 parts of bush, 10 parts of dragon's blood, 10 parts of catechu.

Further include the auxiliary material of following parts by weight proportioning：55 parts of distilled water, 28 parts of sorbierite, 0.06 part of natrium adetate, 4.0 parts of propylene glycol, 9 parts of atoleine, (PEG-30 dimerization hydroxy stearic acid ester is 1 with poloxamer mass ratio to sustained release emulsifier: 1 mixture) 3.0 parts, single 3.0 parts of glyceryl isostearate, 0.3 part of ethylparaben.

Preparation method：

With embodiment 1.

Zoopery

Subjects：ICR mouse 60, SPF grades, female, weight 18g~22g is randomly divided into 5 groups, i.e. normal control Group, model group, 1 group of embodiment, 3 groups of embodiment, positive controls, every group 12.In addition to Normal group, remaining each group with Adhesive tape legal system makes mouse skin mechanical barrier model.Specific method is：Medical adhesive tape is close to the mouse back for removing hair On skin, torn fast immediately.Every mouse is concentrated modeling twice daily, each quantity of stimulus be 5 times " paste --- tear Under " flow.When the time interval of focused stimulation is about 8 small.The modeling time amounts to 5 days.Mouse skin after modeling should be rubescent, but Without hyperemia.

Medication：It is administered after modeling.The medication that 1 group of embodiment be 1 obtained emulsifiable paste of embodiment, embodiment 3 The medication of group is 3 obtained emulsifiable paste of embodiment, and the medication of positive controls is Momestasone furoate cream.Sterile gauze is cut Square into 1*1cm sizes is spare.With remove needle tubing syringe draw each group correspond to emulsifiable paste, by 1 group of embodiment, 3 groups of embodiment, The dosage of daily every 0.3g of positive controls, emulsifiable paste is transferred on gauze, then the gauze is applied in mouse skin machine At tool barrier injury, and pat to promote to absorb.Successive administration 14 days, weighing weight.

Experimental result：

1. moisture content of skin

Moisture content of skin test result part table 1.

Moisture content of skin after the different group mouse of table 1 are administered 14 days

Number	Normal group	Model group	1 group of embodiment	3 groups of embodiment	Positive controls
						1	41.67	41.00	42.33	43.33	41.67
2	43.33	43.33	41.67	43.00	42.67
						3	41.00	35.33	42.67	43.67	41.67
4	39.00	43.00	43.67	43.33	42.67
						5	41.67	33.67	43.00	43.33	39.67
6	30.33	42.67	41.33	43.33	35.67
						7	43.33	39.67	43.00	42.67	43.33
8	42.33	31.67	43.33	43.67	37.33
						9	37.67	43.00	43.67	43.00	42.67
10	43.33	33.67	43.00	43.33	39.67
						11	39.00	42.67	43.33	43.33	41.00
12	43.67	39.67	43.33	42.67	43.33
						Average	40.53	39.11	42.86	43.22	40.94
SD	3.77	4.33	0.74	0.33	2.44

By experimental result as it can be seen that model group is compared with normal group, since skin barrier is damaged water content is caused to decline.Than Compared with 1 group of embodiment, 3 groups of embodiment and model group, it is known that 1 group of embodiment, the moisture content of skin of 3 groups of embodiment have rising, former Because being that the emulsifiable paste that embodiment 1, embodiment 3 are provided draws moist and moisture retention with stronger, therefore skin barrier can be damaged Place keeps certain hydrauture, promotes skin barrier reparation.

2. skin oil and fat content

Skin oil and fat content results are shown in Table 2.Kruskal-Wallis inspections are carried out to 2 result of table, the results are shown in Table 3.

Skin oil and fat content after the different group mouse of table 2 are administered 14 days

3 Kruskal-Wallis of table is examined

Group	N	Order average
			Normal group	12	31.38
Model group	12	37.08
			1 group of embodiment	12	25.13
3 groups of embodiment	12	31.08
			Positive controls	12	27.83
Sum	60

By experimental result as it can be seen that model group mouse is because skin barrier is damaged, smegma grease increases compared to normal group, Increasing for sebum level contributes to closed coat, prevents percutaneous loss of moist.1 group of embodiment, 3 groups of embodiment, positive controls Compared with model group, sebum level is remarkably decreased, it is possible the reason for be to be administered each group containing drawing wet ingredient, skin external environment Moisture is sufficient, due to water shortage skin oil and fat will not be caused to secrete.

3. cellular inflammation dielectric tests

Cellular inflammation dielectric tests the results are shown in Table 4.

Skin interleukin 6 content after the different group mouse of table 4 are administered 14 days

Number	Normal group	Model group	1 group of embodiment	3 groups of embodiment	Positive controls
						1	98.652	157.97	87.4	123.564	88.929
2	144.059	83.942	67.991	145.954	69.719
						3	89.627	147.221	98.367	115.646	82.156
4	105.834	223.652	151.044	98.224	57.637
						5	124.62	114.907	141.075	70.653	48.797
6	104.388	100.365	179.356	67.328	46.395
						7	135.937	134.083	74.408	68.921	61.017
8	128.107	112.548	172.793	77.789	91.585
						9	118.171	93.693	145.006	89.208	59.323
10	108.595	97.94	90.046	67.726	40.886
						11	142.644	139.824	80.513	93.834	40.264
12		116.536	100.508	124.469	46.774
						Average	118.24	126.89	115.71	95.28	61.12

In normal group, the sample values that number is 12 are more than reorganization average plus three times variance, therefore are rejected.By testing As a result as it can be seen that model group is compared with normal group, interleukin 6 content significantly raises, and shows that the destruction of skin barrier has triggered skin The inflammatory reaction of tissue；1 group of embodiment, 3 groups of embodiment are compared with model group, and the content of interleukin 6 significantly reduces, and shows to implement The anti-inflammatory effect for the emulsifiable paste that example 1, embodiment 3 are provided plays a role in the repair process of skin barrier, especially with embodiment 3 Effect it is good.

4. ceramide content is tested

Ceramide content test result is shown in Table 5.

Cutaneous nerve amide content after the different group mouse of table 5 are administered 14 days

Statistical test is carried out to above-mentioned experimental result, the results are shown in Table 6, table 7.

6 test of normality of table

*：The lower limit of the true level of signifiance.

7 Multiple range test of table

*：The significance of equal value difference is 0.05.

By experimental result as it can be seen that 1 group of embodiment, 3 groups of embodiment are compared with model group, ceramide content increases.Especially 3 groups of embodiment is compared with model group, P<0.01, there is significant difference.Illustrating that embodiment 3 has more obviously increases epidermis The effect of middle ceramide content.

5. pathological section

Pathological section, the result is shown in Figure 1~Fig. 5 are carried out to the experiment skin of each group mouse.Wherein, Fig. 1 is in zoopery The experiment skin of normal group mouse carries out pathological section figure；Fig. 2 is that the experiment skin of model group mouse in zoopery carries out disease Manage slice map；Fig. 3 is that the experiment skin of 1 group of mouse of embodiment in zoopery carries out pathological section figure；Fig. 4 is in zoopery The experiment skin of 3 groups of mouse of embodiment carries out pathological section figure；Fig. 5 is the experiment skin of positive control group mice in zoopery Carry out pathological section figure.

By pathological section result as it can be seen that normally group mouse skin is normal, model group epidermis thickens substantially, and cuticula increases Thickness, locally there is the mistake of cutin matter break, and cell level increases.Skin corium has an inflammatory cell infiltration, and body cell increases on gland.It is real Applying 1 group of example, 2 groups of embodiment and positive controls, more than pathological change has different degrees of improvement.

By 1~table of table 5 and Fig. 1~Fig. 5 as it can be seen that embodiment group provided for acne and skin barrier injury repair Emulsifiable paste have good skin barrier repair.

The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention Any modification, equivalent substitution or improvement made within refreshing and principle etc., should all be included in the protection scope of the present invention.

Claims

1. a kind of emulsifiable paste for acne and skin barrier injury repair, it is characterised in that：Including following parts by weight proportioning Raw material：12~15 parts of oldenlandia diffusa, 12~15 parts of climbing groundsel, 12~15 parts of Chinese holly, 12~15 parts of Chinese violet, felwort 8~10 parts, it is 8~10 parts of the root bark of shaggy-fruited dittany, 8~10 parts of barberry, 6~8 parts of Eucalyptus globulus Labill leaf, 6~8 parts of peppermint, 10~12 parts of loguat leaf, grey 8~10 parts of art, 6~8 parts of piper cubeba, 6~8 parts of eclipta, 6~8 parts of Herba Cistanches, 10~12 parts of Radix Paeoniae Alba, 8~10 parts of bush, blood Exhaust 8~10 parts, 8~10 parts of catechu.

2. the emulsifiable paste according to claim 1 for acne and skin barrier injury repair, it is characterised in that：The rough gentian Grass, the root bark of shaggy-fruited dittany, barberry, loguat leaf, rhizoma atractylodis, piper cubeba, eclipta, Herba Cistanches, bush, dragon's blood, catechu are after processing Medicinal material, the oldenlandia diffusa, climbing groundsel, Chinese holly, Chinese violet, Eucalyptus globulus Labill leaf, peppermint, Radix Paeoniae Alba are not processing after cleaning Fresh medicine material.

3. the emulsifiable paste according to claim 2 for acne and skin barrier injury repair, it is characterised in that：The rhizoma atractylodis For wheat bran rhizoma atractylodis；And/or

The eclipta is eclipta charcoal.

4. according to claims 1 to 3 any one of them for the emulsifiable paste of acne and skin barrier injury repair, feature exists In：Further include the auxiliary material of following parts by weight proportioning：51~55 parts of distilled water, 24~28 parts of sorbierite, natrium adetate 0.04 ~0.06 part, 3.5~4.0 parts of propylene glycol, 7~9 parts of atoleine is sustained 2.6~3.0 parts of emulsifier, single isostearic acid glycerine 2.6~3.0 parts of ester, 0.2~0.3 part of ethylparaben.

5. the emulsifiable paste according to claim 4 for acne and skin barrier injury repair, it is characterised in that：Including following The auxiliary material of parts by weight proportioning：53 parts of distilled water, 26 parts of sorbierite, 0.05 part of natrium adetate, 3.75 parts of propylene glycol, liquid stone 8 parts of wax, 2.8 parts of PEG-30 dimerization hydroxy stearic acid ester, single 2.8 parts of glyceryl isostearate, 0.25 part of ethylparaben.

6. the emulsifiable paste according to claim 4 for acne and skin barrier injury repair, it is characterised in that：The sustained release Emulsifier is included at least one of PEG-30 dimerization hydroxy stearic acid ester, Sorbitan Sesquioleate, poloxamer.

7. a kind of existing for acne and the preparation method of the emulsifiable paste of skin barrier injury repair, feature described in claim 4 In, the emulsifiable paste for acne and skin barrier injury repair by the raw material is extracted, filtering, after alcohol precipitation with the auxiliary material It is mixed with.

8. according to claim 7 exist for acne and the preparation method of the emulsifiable paste of skin barrier injury repair, feature In specifically including following steps：

Step a, weigh each raw material by any one of claims 1 to 3 raw material proportioning, by felwort, the root bark of shaggy-fruited dittany, barberry, Loguat leaf, rhizoma atractylodis, piper cubeba, eclipta, Herba Cistanches, bush, dragon's blood, catechu add the water of 7~10 times of the material quality to decoct 40~50 minutes, add in oldenlandia diffusa, climbing groundsel, Chinese violet, Chinese holly, Eucalyptus globulus Labill leaf, peppermint, Radix Paeoniae Alba continue decoction 10~ 20 minutes, filtering added water to cook 1~2 time into filter residue, every time 1~1.5 it is small when, filtering merges all filtrates；

Step c, as described in claim 4, ratio of adjuvant weighs each auxiliary material, by distilled water, sorbierite, natrium adetate, propylene glycol It is uniformly mixed with step b gained supernatants, is heated to 90~95 DEG C and keeps the temperature preservation, obtain water phase；

Step d, atoleine, sustained release emulsifier, single glyceryl isostearate, ethylparaben are uniformly mixed, are heated to 85 ~90 DEG C and preservation is kept the temperature, obtain oil phase；

Step e, the water is mutually added to the speed of 1~3 part/min under the mixing speed of 900~1100r/min described In oil phase, after stirring 20~25min, continue stirring to mixture temperature under the speed of 500~600r/min and be down to 20~30 DEG C to get.

9. according to claim 8 exist for acne and the preparation method of the emulsifiable paste of skin barrier injury repair, feature In to be concentrated under reduced pressure, the relative density for being concentrated into the concentrate is 1.10~1.20 for concentration described in step b；And/or

Concentration expressed in percentage by volume >=95% of ethyl alcohol described in step b, the volume of the ethyl alcohol for the volume of the concentrated liquid 1~ 1.5 times, the time of the standing is 20~30h.

10. acne drug neck is being prepared for the emulsifiable paste of acne and skin barrier injury repair described in claim any one of 1-3 The application in domain.