CN104666784A - Acne treating capsules and preparation method thereof - Google Patents

Abstract

The invention discloses a method for preparing acne treating capsules. The method comprises the following steps: (a) fetching gynura bicolor, common dayflower herb, root of dentiferous dendropanax, prinsepia utilis, rhizoma polygoni runcinati, smilax microphylla and youngia japonica of the weight parts, and making into powder of 50 meshes; adding 85% ethanol according to a feed liquid ratio of 1:9; performing reflux extraction for 3 times, 2 hours each time; merging the reflux liquid; concentrating to obtain an extract with relative density of 1.28-1.32 (38 DEG C); and performing vacuum drying to obtain powder of 200 meshes; and (b) fetching fructus rosae laevigatae and eucommia ulmoides of the weight parts and making into powder of 300 meshes; uniformly mixing with the powder in the step a); and encapsulating, wherein each capsule weighs 0.58g. With the compatibility of the medicines, the synergistic effect is outstanding, and the medicines realize the functions of clearing heat and removing toxicity, activating blood and relieving pain, resisting bacteria and diminishing inflammation and resolving stasis and eliminating swelling; and the preparation technology of the capsules is simple, safe and reliable while the treatment effect on acne is obvious. By adopting the medicine prepared by the method disclosed by the invention to treat acne, the total effective rate reaches 90.99%.

Description

Capsule of a kind of Acne treatment and preparation method thereof

Technical field

The invention belongs to technical field of pharmaceuticals, particularly relate to capsule of a kind of Acne treatment and preparation method thereof.

Background technology

Acne is that a kind of chronic inflammatory skin of pilosebaceous unit is sick, is mainly apt to occur in teenager, to teen-age psychology and social influence very large, but often can naturally alleviate or fully recover after adolescence.Clinical manifestation is to be apt to occur in the pleomorphism skin lesion such as acne, pimple, pustule, tuberosity of face for feature.Modern medicine study is thought, generation and the dietary structure of acne are unreasonable, psychentonia, trace element deficiency, the factors such as heredity are relevant, principal element is that Development in Puberty is ripe, Serum Testosterone Levels increases stimulates sebum secretion to increase, and is difficult to discharge and be gathered in hair follicle, produces papular infringement, sebaceous gland excretion and disturbance of blood circulation are bred to again the infection of antibacterial and are created condition, and secondary hair follicle and perifollicolar are inflamed abscess and tuberosity.

TCM investigation is thought, the morbidity root of acne and deficiency of kidney yin, and the negative and positive (endocrine) of kidney are lacked of proper care relevant, cause hyperactivity of the ministerial fire, stasis skin, or disharmony of Chong and Conception Channels, lung stomach heat in blood stasis smokes women's head-ornaments and causes.

The medicine that can be used for Acne treatment is a lot, but is not often that to fall short of the reality be exactly that toxic and side effects is serious.Accutane as popular is the acne medicine ratified by FDA Food and Drug Administration nineteen eighty-two, be also uniquely approved can the medicine of effective Acne treatment, but have the side effect exciting people to be absorbed in depressive state, can cause time serious committing suiside.Tretinoin conventional in addition can make skin heart sharply expand to occur erythema, and epidermal area is plump, irritant, unsuitable prolonged application.

Although the skin care cosmetics on market has some curative effects to some acnes and various mottle on the surface, is all temporary transient, covering effect can only be played, take stopgap measures and do not effect a permanent cure, not have therapeutical effect at all, can not tackle the problem at its root.

Summary of the invention

The object of this invention is to provide capsule of a kind of Acne treatment and preparation method thereof, Acne treatment Be very effective.

The capsule of Acne treatment of the present invention, is made up of the crude drug of following parts by weight: Radix Semiaquilegiae 18 ~ 20 parts, Herba Commelinae 6 ~ 8 parts, Radix Dendropanacis 8 ~ 10 parts, Folium Prinsepiae Utilis 12 ~ 14 parts, Herba Polygoni Runcinati 13 ~ 15 parts, Radix Smilacis nanae 15 ~ 18 parts, Herba youngiae japonicae 20 ~ 23 parts, Fructus Rosae Laevigatae 4 ~ 5 parts, the Cortex Eucommiae 5 ~ 6 parts.

As optimization, the capsule of this Acne treatment, is made up of the crude drug of following parts by weight: Radix Semiaquilegiae 19 parts, Herba Commelinae 7 parts, Radix Dendropanacis 9 parts, Folium Prinsepiae Utilis 13 parts, Herba Polygoni Runcinati 14 parts, Radix Smilacis nanae 17 parts, Herba youngiae japonicae 22 parts, Fructus Rosae Laevigatae 5 parts, the Cortex Eucommiae 5 parts.

Prepare the method for this Acne treatment capsule, comprise the following steps,

A, the Radix Semiaquilegiae getting described parts by weight, Herba Commelinae, Radix Dendropanacis, Folium Prinsepiae Utilis, Herba Polygoni Runcinati, Radix Smilacis nanae, Herba youngiae japonicae, make 50 object powder; By solid-liquid ratio 1:9, add 85% ethanol, reflux, extract, 3 times, each 2 hours, merge backflow; Be condensed into the extractum that relative density is 1.28 ~ 1.32 (38 DEG C); Then vacuum drying, makes 200 object powder;

B, the Fructus Rosae Laevigatae of getting described parts by weight, the Cortex Eucommiae make 300 object powder; Then with the powder mix homogeneously in step a, according to 0.58 gram one, in incapsulating.

In prescription of the present invention, effect of Radix Semiaquilegiae tool heat-clearing and toxic substances removing, nourishing the lung to arrest cough, dissipating blood stasis for subsidence of swelling, promoting the production of body fluid to quench thirst, controls exogenous high fever, heatstroke fever, cough due to lung-heat, cold hoarseness, carbuncle sore tumefacting virus, the diseases such as treating swelling and pain by traumatic injury.

The capable water of Herba Commelinae, heat clearing away, removing heat from blood, removing toxic substances; Harness the river swollen, beriberi, dysuria, flu, erysipelas, parotitis, icterohepatitis, hematodiarrhoea, malaria, epistaxis, hematuria, metrorrhagia, leucorrhea, laryngopharynx swelling and pain, carbuncle furuncle.

Radix Dendropanacis expelling wind and removing dampness; Promoting blood circulation and detumescence.Main air pain of dampness syndrome; Hemiplegia; Headache; Menoxenia; Traumatic injury; Skin ulcer swells.

Folium Prinsepiae Utilis heat-clearing and toxic substances removing, blood circulation promoting and dispersing pathogen accumulation.Main acute mastitis, mumps, hemorrhoid, scrofula, traumatic injury, menoxenia.

Herba Polygoni Runcinati heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, removing toxic substances and promoting subsidence of swelling; For acute gastroenteritis, spitting of blood of spitting blood, bleeding hemorrhoids, menoxenia, traumatic injury; Mastitis are controlled in external, carbuncle furuncle and phyma poison.

Radix Smilacis nanae dispels the wind; Heat clearing away; Dampness removing; Main air damp-heat arthralgia; Hot urination; Leucorrhea; Furuncle.

Herba youngiae japonicae anti-inflammation; Control furuncle, mastitis, tonsillitis, urinary tract infection, leucorrhea, conjunctivitis, rheumatic arthritis.

The Cortex Eucommiae has invigorating the liver and kidney, and control spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, hypertension, antiabortive effect; Have regulating action in various degree to immune system, hormonal system, central nervous system, blood circulation and urinary system, the Cortex Eucommiae can excited Pituitary Adrenalcortical system, adrenal cortex reinforcing function.

Fructus Rosae Laevigatae has controlling nocturnal emission with astringent drugs reducing urination, stopping metrorrhagia and leukorrhagia, effect of relieving diarrhea with astringents.Be usually used in emission and spermatorrhea, enuresis frequent micturition, bleeding not during menses, chronic diarrhea chronic dysentery.

All medicine compatibilities above, synergy is given prominence to, and jointly plays effect of heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, anti-inflammation, dissipating blood stasis for subsidence of swelling, and this capsules preparation technique is simple, and the safe and reliable therapeutic effect to acne is obvious.Apply Drug therapy acne of the present invention, total effective rate reaches 90.99%.

Detailed description of the invention

The invention will be further described for embodiment plan given below; but can not be interpreted as it is limiting the scope of the invention; those skilled in the art to nonessential improvement and adjustment more of the present invention, still belong to protection scope of the present invention according to content of the present invention.

Embodiment 1, a, get Radix Semiaquilegiae 190 grams, Herba Commelinae 70 grams, Radix Dendropanacis 90 grams, Folium Prinsepiae Utilis 130 grams, Herba Polygoni Runcinati 140 grams, Radix Smilacis nanae 170 grams, Herba youngiae japonicae 220 grams, make 50 object powder, after mix homogeneously; By solid-liquid ratio 1:9, add 85% ethanol, reflux, extract, 3 times, each 2 hours, merge backflow; Be condensed into the extractum that relative density is 1.28 ~ 1.32 (38 DEG C); Then vacuum drying, makes 200 object powder;

B, get Fructus Rosae Laevigatae 50 grams, the Cortex Eucommiae 50 restrains into 300 object powder; Then with the powder mix homogeneously in step a, according to 0.58 gram one, in incapsulating.

Embodiment 2, a, get Radix Semiaquilegiae 180 grams, Herba Commelinae 60 grams, Radix Dendropanacis 80 grams, Folium Prinsepiae Utilis 120 grams, Herba Polygoni Runcinati 130 grams, Radix Smilacis nanae 150 grams, Herba youngiae japonicae 200 grams, make 50 object powder; By solid-liquid ratio 1:9, add 85% ethanol, reflux, extract, 3 times, each 2 hours, merge backflow; Be condensed into the extractum that relative density is 1.28 ~ 1.32 (38 DEG C); Then vacuum drying, makes 200 object powder;

B, get Fructus Rosae Laevigatae 40 grams, the Cortex Eucommiae 50 restrains into 300 object powder; Then with the powder mix homogeneously in step a, according to 0.58 gram one, in incapsulating.

Embodiment 3, a, get Radix Semiaquilegiae 200 grams, Herba Commelinae 80 grams, Radix Dendropanacis 100 grams, Folium Prinsepiae Utilis 140 grams, Herba Polygoni Runcinati 150 grams, Radix Smilacis nanae 180 grams, Herba youngiae japonicae 230 grams, make 50 object powder; By solid-liquid ratio 1:9, add 85% ethanol, reflux, extract, 3 times, each 2 hours, merge backflow; Be condensed into the extractum that relative density is 1.28 ~ 1.32 (38 DEG C); Then vacuum drying, makes 200 object powder;

B, get Fructus Rosae Laevigatae 50 grams, the Cortex Eucommiae 60 restrains into 300 object powder; Then with the powder mix homogeneously in step a, according to 0.58 gram one, in incapsulating.

Experimental summary is reported as follows.Physical data: patients with acne 222 example, is divided into two groups immediately, often organizes 111 examples.Treatment group man 60 example, female 51 example.Matched group man 61 example, female 50 example.Two groups in sex, the age, roughly similar in the course of disease, through statistical procedures, difference there are no significant meaning (P > 0.05).

Diagnostic criteria: in " the Chinese medical disease Standardization of diagnosis and curative effect " issued according to State Administration of Traditional Chinese Medicine 1994 acne diagnostic criteria: 1) from the beginning of the red papules presenting small rice grain size at follicular orifice, purulent core can be developed into, after this can form scleroma sample white acne or blackhead, several cases can form scleroma property cyst; 2) be mainly in the face of adolescence men and women, chest and back, often have seborrhea; 3) how by eating and drinking without temperance, surfeit delicious food savoury, or sense exopathogen etc. brings out; 4) women many with menstruationuncomfortable; 5) course of disease repeatedly, in chronic process, can be formed cicatrix.

Exclusion standard: 1) age person more than 35 years old; 2) pregnancy women; 3) occupational acne; 4) severe cardiac, liver, renal damage and disease of hematopoietic system person is had.

Therapeutic Method: the treatment group oral embodiment of the present invention 1 capsule, every day 3 times, each 2, takes 3 months continuously.The PAIDU YANGYAN JIAONANG of the oral interwined dragon sea of clouds of matched group, every day 2 times, each 4 one month is a course for the treatment of.

Criterion of therapeutical effect: according to the efficacy assessment standard of acne in " Chinese medical disease Standardization of diagnosis and curative effect ", cure: skin lesion disappears, subjective symptoms disappears; Take a turn for the better: subjective symptoms obviously alleviates, and skin lesion disappears more than 30%; Do not heal: skin lesion and symptom unchanged or disappear less than 30%.Treatment comparative result refers to table 1.

Claims (3)

1. a capsule for Acne treatment, is characterized in that being made up of the crude drug of following parts by weight: Radix Semiaquilegiae 18 ~ 20 parts, Herba Commelinae 6 ~ 8 parts, Radix Dendropanacis 8 ~ 10 parts, Folium Prinsepiae Utilis 12 ~ 14 parts, Herba Polygoni Runcinati 13 ~ 15 parts, Radix Smilacis nanae 15 ~ 18 parts, Herba youngiae japonicae 20 ~ 23 parts, Fructus Rosae Laevigatae 4 ~ 5 parts, the Cortex Eucommiae 5 ~ 6 parts.

2., according to the capsule of claim 1 Acne treatment, it is characterized in that being made up of the crude drug of following parts by weight: Radix Semiaquilegiae 19 parts, Herba Commelinae 7 parts, Radix Dendropanacis 9 parts, Folium Prinsepiae Utilis 13 parts, Herba Polygoni Runcinati 14 parts, Radix Smilacis nanae 17 parts, Herba youngiae japonicae 22 parts, Fructus Rosae Laevigatae 5 parts, the Cortex Eucommiae 5 parts.

3. prepare a method for Acne treatment capsule described in claim 1, it is characterized in that comprising the following steps,

A, the Radix Semiaquilegiae getting described parts by weight, Herba Commelinae, Radix Dendropanacis, Folium Prinsepiae Utilis, Herba Polygoni Runcinati, Radix Smilacis nanae, Herba youngiae japonicae, make 50 object powder; By solid-liquid ratio 1:9, add 85% ethanol, reflux, extract, 3 times, each 2 hours, merge backflow; Be condensed into the extractum that relative density is 1.28 ~ 1.32 (38 DEG C); Then vacuum drying, makes 200 object powder;

B, the Fructus Rosae Laevigatae of getting described parts by weight, the Cortex Eucommiae make 300 object powder; Then with the powder mix homogeneously in step a.