CN102178893B - Composite medicine for treating acne - Google Patents

Abstract

The invention discloses a composite medicine for treating acne, which is prepared by the steps of: crushing lightyellow sophora root, china root, flos lonicerae, common burreed rhizome, zedoary, aristolochiae lignum, Chinese rhubarb, radix angelicae pubescentis, spreading hedyotis herb and mongolian dandelion herb into fine powder, and adding cimetidine for mixing to prepare capsules. The Chinese medicinal herbs are matched in the cimetidine, so that the composite medicine has a remarkable treatment effect on the acne and is proved by clinical experiments to reach a total effective rate of 93.3 percent.

Description

A kind of compound medicine that is used to treat acne

Technical field

The present invention relates to a kind of medicine that is used to treat acne, particularly relate to a kind of in cimetidine the compound medicine of the treatment acne of compatibility Chinese medicine.

Background technology

Acne is commonly called as comedo, acne, whelk, skin sore, is that a kind of common skin is sick, is more common in the adolescence men and women, good usually sending out in face, cervical region, chest and back, shoulder and upper arm.Acne belongs to the chronic inflammatory disease dermatoses of pilosebaceous unit; Clinical serves as main performance with hoary hair's acne, blackhead, inflammatory pimple, pustule, tuberosity, cyst etc.; For the youngster of adolescence especially for very; But also not exclusively receive the restriction of age level, from child to adult, the people of nearly all age bracket can fall ill.Opinions vary though it is formed mechanism, still imperfectly understands so far, certainly relevant with outside infection with the human endocrine imbalance.

Modern medicine study thinks that the generation and the dietary structure of acne are unreasonable, psychentonia; Trace element deficiency, many factors such as heredity are relevant, and principal element is that adolescence is reached maturity; The androgen level increases stimulates sebum secretion to increase, and is difficult to discharge and is gathered in the hair follicle, produces the infringement of pimple property; Sebaceous gland is drained and disturbance of blood circulation has created condition for again the infection breeding of antibacterial, and abscess and tuberosity are inflamed around secondary hair follicle and the hair follicle.

Traditional Chinese medical science research is thought, the morbidity root and the deficiency of kidney yin of acne, and the negative and positive of kidney (endocrine) imbalances is relevant, causes hyperactivity of the ministerial fire, stasis skin, or disharmony of Chong and Conception Channels, smoked women's head-ornaments on the lung stomach heat in blood stasis and causing.

The medicine that can be used for treating acne is a lot, but often is not that to fall short of the reality be exactly that toxic and side effects is serious.Like popular Accutane is nineteen eighty-two by the acne medicine of FDA Food and Drug Administration's approval, also is uniquely approvedly can effectively treat the medicine of acne, excites the people to be absorbed in the side effect of depressive state but have, and can cause when serious committing suiside.Tretinoin commonly used in addition can make the rapid expansion of skin heart erythema occur, and epidermal area is plump, and zest is arranged, unsuitable prolonged application.

Though go up on the skin care cosmetics on market surface some acnes and various mottle being had some curative effects, all is temporary transient, can only play the covering effect, takes stopgap measures and does not effect a permanent cure, and does not have therapeutical effect at all, can not tackle the problem at its root.

Summary of the invention

The purpose of this invention is to provide a kind of compound medicine that is used to treat acne, compatibility is with Chinese medicine in the Western medicine cimetidine for this medicine, and treatment acne effect is remarkable.

Compound medicine of the present invention is that the crude drug by following ratio of weight and number prepares:

Radix Sophorae Flavescentis 25～35 Rhizoma Smilacis Glabraes 25～35

Flos Lonicerae 25～35 triangular 10～20

Rhizoma Curcumae 10～20 Caulis Akebiaes 10～20

Radix Et Rhizoma Rhei 10～20 Radix Angelicae Pubescentiss 20～30

Herba Hedyotidis Diffusae 25～35 Herba Taraxacis 30～50

Cimetidine 15～30.

The present invention processes capsule with said medicine, and its concrete method for preparing is:

Said Chinese medicine powder is broken into 300～500 purpose fine powders, behind said parts by weight mix homogeneously, adds the cimetidine of said parts by weight, mix homogeneously, in incapsulating, sterilization is processed the capsule product.

In the prescription of the present invention, cimetidine another name cimetidine is applicable to treatment duodenal ulcer, gastric ulcer, upper gastrointestinal hemorrhage etc., also has the antiandrogen effect, can treat hirsutism etc., also can be used as antianaphylactic auxiliary treatment.Add the effect of Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae, the outstanding heat clearing and damp drying of Herba Hedyotidis Diffusae simultaneously, and play the effect of heat-clearing and toxic substances removing with Flos Lonicerae, Herba Taraxaci.In addition, triangular, Rhizoma Curcumae circulation of qi promoting removing blood stasis with potent drugs reduces phlegm; Caulis Akebiae pathogenic fire purging row water, promoting blood circulation; Radix Et Rhizoma Rhei clearing away heat and cooling blood, blood stasis dispelling detoxifcation; The Radix Angelicae Pubescentis expelling wind and dampness, dispersing cold for relieving pain.More than all medicine compatibilities, play clearing away heat and expelling pathogen in the exterior jointly, blood circulation promoting and blood stasis dispelling, detumescence and apocenosis, the granulation promoting pain relieving, dredge the meridian passage, the effect of coordinating YIN and YANG, to because of deficiency of the lung hyperactivity of fire, the therapeutic effect such as acne that dampness causes are obvious.

Use Drug therapy acne of the present invention clinically, total effective rate reaches 93.3%, and the clinical experiment final report is following.

Collect patients with acne 60 examples, be divided into two groups immediately, every group 30 example.Male 18 examples are organized in treatment, women 12 examples, 14～35 years old age, average (21.0 ± 3.3) year, the course of disease 2 months～18 years, average (3.5 ± 2.1) year.Matched group man 16 examples, women 14 examples, 12～34 years old age, average (22.3 ± 2.8) year, the course of disease 3 months～17 years, average (3.7 ± 2.5) year.Two groups in sex, the age, and roughly similar on the course of disease, through statistical procedures, difference there are no significant meaning (P＞0.05).

Diagnostic criteria: according to acne in " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " of State Administration of Traditional Chinese Medicine 1994 issue diagnostic criteria: 1) from the beginning of the red pimple that presents the small rice grain size at follicular orifice; Can develop into purulent core; After this can form scleroma white acne of appearance or blackhead, serious case can form scleroma property cyst; 2) be mainly in adolescence men and women's face, chest and back often has seborrhea; 3) many by eating and drinking without temperance, surfeit delicious food savoury, or sense exopathogen etc. brings out; 4) women is many with menoxenia; 5) course of disease is chronic process repeatedly, can form cicatrix.

Exclusion standard: 1) age is person more than 35 years old; 2) pregnancy women; 3) occupational acne; 4) severe cardiac, liver, renal damage and disease of hematopoietic system person are arranged.

Therapeutic Method: oral capsule of the present invention is organized in treatment, every day 3 times, each 2, takes continuously 3 months.The oral cimetidine tablet of matched group (specification 0.2g), every day 3 times, each 1.

Criterion of therapeutical effect: according to the efficacy assessment standard of acne in " traditional Chinese medical science disease diagnosis criterion of therapeutical effect ", cure: skin lesion disappears, and subjective symptoms disappears; Take a turn for the better: subjective symptoms obviously alleviates, and skin lesion disappears more than 30%; Do not heal: skin lesion and symptom no change or the less than 30% that disappears.

Therapeutic outcome: the treatment group is cured 1 example (3.3%), 27 examples that take a turn for the better (90.0%), invalid 2 examples (6.7%), total effective rate 93.3%; Matched group 5 examples (16.7%) that take a turn for the better, invalid 25 examples (83.3%), 16.7%, two group of comparing difference of total effective rate has significance (P < 0.01).

The specific embodiment

Embodiment 1

Get Radix Sophorae Flavescentis 60g, Rhizoma Smilacis Glabrae 60g, Flos Lonicerae 60g, triangular 30g, Rhizoma Curcumae 30g, Caulis Akebiae 30g, Radix Et Rhizoma Rhei 30g, Radix Angelicae Pubescentis 50g, Herba Hedyotidis Diffusae 60g, Herba Taraxaci 80g; Be ground into 300 purpose fine powders; Add cimetidine 50g mix homogeneously; In incapsulating, sterilization is processed the capsule product.

Embodiment 2

Get Radix Sophorae Flavescentis 70g, Rhizoma Smilacis Glabrae 70g, Flos Lonicerae 70g, triangular 20g, Rhizoma Curcumae 20g, Caulis Akebiae 20g, Radix Et Rhizoma Rhei 40g, Radix Angelicae Pubescentis 40g, Herba Hedyotidis Diffusae 50g, Herba Taraxaci 90g; Be ground into 400 purpose fine powders; Add cimetidine 60g mix homogeneously; In incapsulating, sterilization is processed the capsule product.

Embodiment 3

Get Radix Sophorae Flavescentis 50g, Rhizoma Smilacis Glabrae 50g, Flos Lonicerae 50g, triangular 40g, Rhizoma Curcumae 40g, Caulis Akebiae 40g, Radix Et Rhizoma Rhei 20g, Radix Angelicae Pubescentis 60g, Herba Hedyotidis Diffusae 60g, Herba Taraxaci 60g; Be ground into 500 purpose fine powders; Add cimetidine 40g mix homogeneously; In incapsulating, sterilization is processed the capsule product.

Claims (2)

1. compound medicine that is used to treat acne is prepared by the crude drug of following ratio of weight and number:

Radix Sophorae Flavescentis 25～35 Rhizoma Smilacis Glabraes 25～35

Flos Lonicerae 25～35 triangular 10～20

Rhizoma Curcumae 10～20 Caulis Akebiaes 10～20

Radix Et Rhizoma Rhei 10～20 Radix Angelicae Pubescentiss 20～30

Herba Hedyotidis Diffusae 25～35 Herba Taraxacis 30～50

Cimetidine 15～30.

2. the said method for preparing that is used to treat the compound medicine of acne of claim 1; Be that said Chinese medicine powder is broken into 300～500 purpose fine powders, behind said parts by weight mix homogeneously, add the cimetidine of said parts by weight; Mix homogeneously; In incapsulating, sterilization is processed the capsule product.