CN101214365B

CN101214365B - Chinese medicine composing prescription for treating mastoproliferation

Info

Publication number: CN101214365B
Application number: CN2008100139220A
Authority: CN
Inventors: 李仕金; 安兵
Original assignee: Individual
Current assignee: Individual
Priority date: 2008-01-14
Filing date: 2008-01-14
Publication date: 2010-06-09
Anticipated expiration: 2028-01-14
Also published as: CN101214365A

Abstract

The present invention discloses a Chinese medicine prescription for curing hyperplasia of mammary glands, including the following crude Chinese drugs with the weight portions: 6 to 15g of lucid asparagus, 6 to 15g of radix bupleuri, 6 to 30g of white peony, 6 to 15g of degelatined deer-horn, 10 to 20g of mornda root, 6 to 15g of curculigo rhizome, 6 to 20g of angelica, 10 to 50g of dandelion, 10 to 25g of cynamorlum, 6 to 15g of common burreed tuber, 5 to 20g of barbated skullcup herb, 3 to 10g of edible tulip, 6 to 15g of cyperus tuber, 6 to 15g of immature orange fruit, 6 to 15g of green tangerine peel, 6 to 15g of radix curcumae, 10 to 30g of kelp and 6 to 20g of cocos poria. The present invention takes the principle of ''dispersing stagnated liver qi and relieving qi stagnation, absorbing clots and clearing away phlegm, softening and resolving hard mass, regulating thoroughfare and controlling vessels, tonifying liver and kidney, strengthening vital qi and eliminating pathogenic factor to cure hyperplasia of mammary glands. The Chinese medicine has reasonable prescription, no side effect, convenient process, low cost and obvious curing effect.

Description

A kind of Chinese prescription for the treatment of cyclomastopathy

Technical field

The present invention relates to a kind of Chinese medicine composition for the treatment of cyclomastopathy, belong to traditional Chinese medical science field.

Background technology

Cyclomastopathy is that the women is common, one of frequently-occurring disease, and it is the hyperplasia of prostate of mammary gland tissue.Be more common in 25-45 year women.Child-bearing period women about 36% has cyclomastopathy in various degree.It is the disorder of the mammary gland normal configuration that causes of a kind of physiology hypertrophy and subinvolution in essence.It neither inflammation neither tumor.So claim " cyclomastopathy ".The World Health Organization's general designation " optimum mammary dysplasia ".

Hormone medicine treatment cyclomastopathy, though short-term effect is good, can obvious relief of symptoms, but prolonged application can be disturbed the balance between the human hormone, the relapse rate height, and in various degree side effect is arranged, should not be as routine administration.Motherland's medical science is controlled the opinion of primary disease and has been carried out many discussions, has accumulated a large amount of effective principle-method-recipe-medicineses, and cyclomastopathy is had the effect of obvious mutation anti-promoting.There is the shortcoming that compatibility is unreasonable, curative effect is not remarkable, treatment time is long, relapse rate is higher in some Chinese medicine sometimes with " hard masses softening and resolving, pain, the heat-clearing and toxic substances removing of disappearing of invigorating blood circulation " treatment cyclomastopathy.

Summary of the invention

The purpose of this invention is to provide a kind of effect significantly, have no side effect, medication is convenient, the Chinese prescription of treatment cyclomastopathy with low cost, for realizing above purpose, the technical solution used in the present invention is:

This Chinese prescription is formulated by following Chinese medicinal raw materials in proportion by weight: Radix Asparagi 6-15g, Radix Bupleuri 6-15g, Radix Paeoniae Alba 6-30g, Cornu Cervi Degelatinatum 6-15g, Radix Morindae Officinalis 10-20g, Rhizoma Curculiginis 6-15g, Radix Angelicae Sinensis 6-20g, Herba Taraxaci 10-50g, Herba Cistanches 10-25g, rhizoma sparganic 6-15g, Rhizoma Curcumae 6-15g, Herba Scutellariae Barbatae 5-20g, Pseudobulbus Cremastrae Seu Pleiones 3-10g, Rhizoma Cyperi 6-15g, Fructus Aurantii Immaturus 6-15g, Pericarpium Citri Reticulatae Viride 6-15g, Radix Curcumae 6-15g, Thallus Laminariae (Thallus Eckloniae) 10-30g, Poria 6-20g.

The optimum weight ratio of each raw material of Chinese medicine is: Radix Asparagi 12g, Radix Bupleuri 9g, Radix Paeoniae Alba 9g, Cornu Cervi Degelatinatum 9g, Radix Morindae Officinalis 9g, Rhizoma Curculiginis 9g, Radix Angelicae Sinensis 9g, Herba Taraxaci 12g, Herba Cistanches 9g, rhizoma sparganic 9g, Rhizoma Curcumae 9g, Herba Scutellariae Barbatae 9g, Pseudobulbus Cremastrae Seu Pleiones 5g, Rhizoma Cyperi 9g, Fructus Aurantii Immaturus 9g, Pericarpium Citri Reticulatae Viride 9g, Radix Curcumae 9g, Thallus Laminariae (Thallus Eckloniae) 15g, Poria 9g.

Radix Bupleuri: return pericardium channel, liver, tri-jiao channel: the elevate a turnable ladder yang-energy is arranged, can reach irritability and dispersing the stagnated live-QI to relieve the stagnation of QI by bar.Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride are returned liver, stomach warp: it is gynecological's principal agent that disappear stagnant, Rhizoma Cyperi of depressed liver-energy dispersing and QI regulating, eliminating stagnation is arranged, and is applicable to depression of liver-QI especially and the menoxenia that causes, diseases such as distending pain of the breast caking.Motherland's medical science records the people and controls the sick theory of breast from heart opinion, the heart controlling mental and emotional activities, and liver controlling conveyance and dispersion, all relevant with the activity of spiritual feelings will.Radix Angelicae Sinensis, the Radix Paeoniae Alba return liver, spleen channel: blood-supplementing blood-nourishing, easing the affected liver to relieve pain, suppressing liver-YANG, the two is gynecological's regulating menstruation key medicine.Cornu Cervi Degelatinatum is returned liver, kidney channel, invigorating the liver and kidney, and benefiting essence-blood is applicable to insufficiency of kidney-YANG.Rhizoma Curculiginis, Radix Morindae Officinalis, Herba Cistanches are returned liver, kidney channel, large intestine channel: reinforcing the kidney and supporting YANG, Herba Cistanches " book on Chinese herbal medicine converges and says " is said: the key medicine of the foster gate of vitality, nourishing kidney gas, replenishing vital essence and blood also.The red first cold caused by deficiency of man and Yang Dao is heavy for a long time, women's Chong and Ren channel disorder and cloudy gas is not controlled, this is the agent of flat benefits, temperature and not hot is mended and not high, warm and not dry cunning and not letting out, so name is calmly arranged.Radix Asparagi, return the lung kidney channel: lung heat clearing pathogenic fire reducing, nourshing Yin and drynsessmoistening prescription has report treatment distending pain of the breast to imitate good.Radix Curcumae GUIXIN liver, gallbladder meridian, promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, the removing heat from blood essentials of Matea Medica that clears away heart-fire says that " the blood removing blood stasis with potent drugs is let out in promoting QI circulation for relieving depression.Removing heat from blood heat, the stagnation of liver-QI of loosing." the retrograde key medicine of treatment married woman blood vessels.Rhizoma Curcumae, rhizoma sparganic, return liver, spleen channel: removing blood stasis, promoting the circulation of QI to relieve pain Compendium of Material Medica say that " rhizoma sparganic can relieving stagnant and resolving masses, so can control all diseases." Fructus Aurantii Immaturus returns spleen, stomach warp: dispelling the stagnated QI removing food stagnancy, the blood stasis dispelling painful abdominal mass of dispelling." not Lu " say " remove the costa sternales accumulation of phlegm in the hypochondrium, cut off the water then, broken solid, the full spasm in the epigastrium painful abdominal mass pain of relieving distension, contrary gas rib wind pain, peace gastric qi." Thallus Laminariae (Thallus Eckloniae) returns liver, kidney, stomach warp: the numbness that disappears softening the hard mass, diuretic.Poria GUIXIN spleen, kidney channel, promoting diuresis to eliminate damp pathogen, spleen-benefiting mind-tranquilizing.Poria is for controlling the expectorant principal agent.This water of expectorant also, Poria can be gone water; Expectorant is moving, wets also, and Poria can be gone wet.Herba Taraxaci, Herba Scutellariae Barbatae, Pseudobulbus Cremastrae seu Pleiones are returned liver, stomach warp: heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation dampness removing, all medicines have antitumaous effect, for the key medicine of treatment cancer prevents canceration to have certain effect with little dosage.Herba Taraxaci also has the function of mediation latex dust.More than the compatibility of all medicines, will play good effect to the treatment cyclomastopathy.

The present invention is directed to the cause of disease " feelings will internal injury, depression of liver-QI, deficiency of kidney-QI, Chong and Ren channel disorder; the expectorant stasis of blood is condensed " of cyclomastopathy, with " dispersing the stagnated live-QI to relieve the stagnation of QI, blood stasis dispelling expectorant; hard masses softening and resolving, regulating thoroughfare and controlling vessel, liver and kidney tonifying; strengthening vital QI to eliminate pathogenic factors " treatment cyclomastopathy, this Chinese prescription compatibility is reasonable, has no side effect, easy to process, with low cost, therapeutic effect is obvious, through the observation of clinical 1200 cases, cure rate 65%, total effective rate is more than 97%.

The specific embodiment

The present invention will be further described below in conjunction with embodiment:

Following each raw material of Chinese medicine of at first weighing: Radix Asparagi 12g, Radix Bupleuri 9g, Radix Paeoniae Alba 9g, Cornu Cervi Degelatinatum 9g, Radix Morindae Officinalis 9g, Rhizoma Curculiginis 9g, Radix Angelicae Sinensis 9g, Herba Taraxaci 12g, Herba Cistanches 9g, rhizoma sparganic 9g, Rhizoma Curcumae 9g, Herba Scutellariae Barbatae 9g, Pseudobulbus Cremastrae Seu Pleiones 5g, Rhizoma Cyperi 9g, Fructus Aurantii Immaturus 9g, Pericarpium Citri Reticulatae Viride 9g, Radix Curcumae 9g, Thallus Laminariae (Thallus Eckloniae) 15g, Poria 9g; Mix the back crushing screening then, general controlling the water circulation ball after drying; Packing had both got finished product behind the last granulate subfield.

Also can adopt conventional Chinese medicinal preparation method to make capsule, drop pill, decoction etc.

Below the Shu Qi ball of producing according to prescription of the present invention is carried out toxicological experiment and clinical experiment explanation:

1, toxicological experiment:

The Shu Qi ball was through toxicological experiment, long term toxicity test continuous use 60 days, and dosage is 6.5 times of clinical application amount, and laboratory animal does not have obvious poisoning symptom, does not have obvious hepatic and renal function injure; LD ₅₀No dead mouse; Maximum tolerated dose surpasses 500 times of human body dosage; Acute lethal dose is greater than 950 times of the human body dosage.

2, clinical comparison experiment:

1) grouping situation: the 260 routine patients that will meet diagnostic criteria are divided into treatment group and matched group at random, i.e. Shu Qi pill for curing group and RUPIXIAO, vitamin E matched group, and wherein 190 examples are organized in treatment, matched group 70 examples.

2) the treatment medication and the course of treatment

Treatment group: oral Shu Qi ball 9g, every day 3 times.Matched group: 6 vitamin E2 grains of oral RUPIXIAO, every day 3 times.Two groups all with 3 courses of treatment, promptly finish to observe, and method of administration is respectively the clean back of menstruation to begin to take medicine in the 6th, the 10th, the 15th, and taking medicine respectively is 20 days first courses of treatment, 15 days second courses of treatment, 10 days the 3rd courses of treatment, adds up curative effect after totally 3 courses of treatment.

3) criterion of therapeutical effect and efficacy result:

The clinical efficacy standard is carried out according to " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " of 1994 issues of the Chinese State Administration of Traditional Chinese Medicines.(cure: lump in breast and pain disappear; Take a turn for the better: lump in breast dwindles pain relief or disappearance; Do not heal: lump in breast and pain no change.)

Through 3 course of therapy analysis and observations to efficacy result be summarized as follows:

Table 1 liang group curative effect relatively

Statistical procedures: X ²=19.71 P=0.0002, P＜0.001 has the significance difference.

The comparison of table 2 liang component type therapeutic effect

Observe from two groups of treatments: no matter the treatment group is at Chong and Ren channel disorder type, and liver energy depression and phlegm stagnation type and mixed type therapeutic effect are all felt quite pleased.Matched group is to the therapeutic effect of Chong and Ren channel disorder type, and not as liver energy depression and phlegm stagnation type, analgesic effect is satisfied, and the endocrine effect of taking good care of oneself is relatively poor.

Claims

1. a Chinese medicine composition for the treatment of cyclomastopathy is characterized in that by following Chinese medicinal raw materials in proportion by weight formulated: Radix Asparagi 6-15g, Radix Bupleuri 6-15g, Radix Paeoniae Alba 6-30g, Cornu Cervi Degelatinatum 6-15g, Radix Morindae Officinalis 10-20g, Rhizoma Curculiginis 6-15g, Radix Angelicae Sinensis 6-20g, Herba Taraxaci 10-50g, Herba Cistanches 10-25g, rhizoma sparganic 6-15g, Rhizoma Curcumae 6-15g, Herba Scutellariae Barbatae 5-20g, Pseudobulbus Cremastrae Seu Pleiones 3-10g, Rhizoma Cyperi 6-15g, Fructus Aurantii Immaturus 6-15g, Pericarpium Citri Reticulatae Viride 6-15g, Radix Curcumae 6-15g, Thallus Laminariae (Thallus Eckloniae) 10-30g, Poria 6-20g.

2. a kind of Chinese medicine composition for the treatment of cyclomastopathy according to claim 1 is characterized in that the optimum weight ratio of each raw material of Chinese medicine is: Radix Asparagi 12g, Radix Bupleuri 9g, Radix Paeoniae Alba 9g, Cornu Cervi Degelatinatum 9g, Radix Morindae Officinalis 9g, Rhizoma Curculiginis 9g, Radix Angelicae Sinensis 9g, Herba Taraxaci 12g, Herba Cistanches 9g, rhizoma sparganic 9g, Rhizoma Curcumae 9g, Herba Scutellariae Barbatae 9g, Pseudobulbus Cremastrae Seu Pleiones 5g, Rhizoma Cyperi 9g, Fructus Aurantii Immaturus 9g, Pericarpium Citri Reticulatae Viride 9g, Radix Curcumae 9g, Thallus Laminariae (Thallus Eckloniae) 15g, Poria 9g.