CN106804643A - A kind of clinical laboratory Chinese medicine sterilizing thimerosal - Google Patents
A kind of clinical laboratory Chinese medicine sterilizing thimerosal Download PDFInfo
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Abstract
The present invention relates to application in TCM field, a kind of clinical laboratory Chinese medicine sterilizing thimerosal is particularly disclosed.A kind of clinical laboratory Chinese medicine sterilizing thimerosal, by oriental wormwood, galingal, turmeric, airpotato yam, the fruit of Chinese magnoliavine, the capsule of weeping forsythia, the root of Dahurain angelica, perilla leaf, the wind-weed, Chinese prickly ash, setose thistle, the Radix Astragali, curcuma zedoary, folium isatidis, Sargent gloryvine, madder, peppermint, notopterygium root, rattletop, radix bupleuri, rhizoma alismatis, Chinese ephedra, cassia twig, it is windproof, Changshan, eupatorium, stone reed, Ramulus Taxilli, frutus cnidii, the fleece-flower root, chrysanthemum, the root of Beijing euphorbia, lilac daphne, the radix paeoniae rubrathe, fringed pink, giant knotweed, flea stops, Radix Angelicae Sinensis is made according to certain weight proportion of modern advanced medical pharmaceutical technology, it is strong with sterilizing ability, work fast, the remarkable advantage of good stability, it is adapted to the sterilizing of clinical laboratory and other section office of hospital, it is free from environmental pollution, it is non-stimulated to humans and animals, have no toxic side effect, it is a kind of preferable germ killing drugs being worthy to be popularized.
Description
（One）Technical field
The present invention relates to application in TCM field, more particularly to a kind of clinical laboratory's Chinese medicine sterilizing thimerosal.
（Two）Background technology
Clinical laboratory is the bridge between clinical medicine and preclinical medicine, including clinical chemistry, clinical microbiology, clinical immunology, hematology, osology and subdiscipline etc. transfusion science.Clinical laboratory carries out the section office of medical test as hospital, and inspection need of work is aseptically carried out, to prevent bacterium, fungi and virus etc. to be mixed into inspection specimen, influence test effect, make assay inaccurate, therefore, the sterilizing work of clinical laboratory is particularly significant.
（Three）The content of the invention
The present invention is in order to make up the deficiencies in the prior art, there is provided a kind of to prepare a kind of clinical laboratory Chinese medicine sterilizing thimerosal simple, evident in efficacy.
The present invention is achieved through the following technical solutions：
A kind of clinical laboratory Chinese medicine sterilizing thimerosal, be made the effective ingredient raw material composition and parts by weight be：10-25 grams of oriental wormwood,10-26 grams of galingal,11-26 grams of turmeric,12-25 grams of airpotato yam,10-25 grams of the fruit of Chinese magnoliavine,10-26 grams of the capsule of weeping forsythia,10-26 grams of the root of Dahurain angelica,10-25 grams of perilla leaf,10-24 grams of the wind-weed,10-26 grams of Chinese prickly ash,10-23 grams of setose thistle,10-26 grams of the Radix Astragali,10-25 grams of curcuma zedoary,10-25 grams of folium isatidis,10-26 grams of Sargent gloryvine,10-26 grams of madder,10-25 grams of peppermint,10-22 grams of notopterygium root,10-23 grams of rattletop,10-23 grams of radix bupleuri,10-26 grams of rhizoma alismatis,10-25 grams of Chinese ephedra,10-29 grams of cassia twig,Windproof 10-26 grams,10-25 grams of Changshan,10-26 grams of eupatorium,10-25 grams of stone reed,10-22 grams of Ramulus Taxilli,10-26 grams of frutus cnidii,10-25 grams of the fleece-flower root,10-26 grams of chrysanthemum,10-26 grams of the root of Beijing euphorbia,10-25 grams of lilac daphne,10-23 grams of the radix paeoniae rubrathe,10-26 grams of fringed pink,10-25 grams of giant knotweed,Flea stops 10-25 grams,10-25 grams of Radix Angelicae Sinensis.
Preferably, be made the effective ingredient raw material composition and parts by weight be：10 grams of oriental wormwood, 10 grams of galingal, 11 grams of turmeric, 12 grams of airpotato yam, 10 grams of the fruit of Chinese magnoliavine, 10 grams of the capsule of weeping forsythia, 10 grams of the root of Dahurain angelica, 10 grams of perilla leaf, 10 grams of the wind-weed, 10 grams of Chinese prickly ash, 10 grams of setose thistle, 10 grams of the Radix Astragali, 10 grams of curcuma zedoary, 10 grams of folium isatidis, 10 grams of Sargent gloryvine, 10 grams of madder, 10 grams of peppermint, 10 grams of notopterygium root, 10 grams of rattletop, 10 grams of radix bupleuri, 10 grams of rhizoma alismatis, 10 grams of Chinese ephedra, 10 grams of cassia twig, windproof 10 grams, 10 grams of Changshan, 10 grams of eupatorium, 10 grams of stone reed, 10 grams of Ramulus Taxilli, 10 grams of frutus cnidii, 10 grams of the fleece-flower root, 10 grams of chrysanthemum, 10 grams of the root of Beijing euphorbia, 10 grams of lilac daphne, 10 grams of the radix paeoniae rubrathe, 10 grams of fringed pink, 10 grams of giant knotweed, flea stops 10 grams, 10 grams of Radix Angelicae Sinensis.
Will above-mentioned Chinese medicine clean after decoct, filter residue, cool after, according to 1:9 ratio mixes with 75% alcoholic solution, standing, filter residue after being well mixed, and using modern advanced pharmacy science and technology, is made sterilized washing lotion, as described clinical laboratory Chinese medicine sterilizing thimerosal.
The property of medicine of Chinese medicine used of the invention is as follows：
Oriental wormwood：Cold nature, it is bitter, pungent.Returns spleen warp, stomach, bladder warp.Clearing away damp-heat, removing jaundice subcutaneous ulcer.The damp-excreting anti-icteric medicinal of category damp-clearing drug subordinate's classification.With controlling jaundice oliguria, wet sore itch, infectious jaundice hepatitis.Containing folic acid, volatile oil;Contain 6,7- dimethoxys coumarin, potassium chloride and chlorogenic acid in flower and fruit.With cholagogic, antipyretic, lipid-loweringing, hypotensive, relieving asthma, antibacterial, antiviral, diuresis, the effect such as anticancer, have inhibitory action to hepatitis viruse.
Galingal：Property heat, taste is pungent.Returns spleen warp, stomach.Warm stomach preventing or arresting vomiting, eliminating cold to stop pain.Category drugs for dispelling internal cold.With controlling coldness and pain in the epigastrium, gastrofrigid vomiting, belch acid regurgitation.Rhizome contains various diarylheptanoids, flavone compound, it is also possible to containing rhamnocitrin and 7- hydroxyl -3,5- dimethoxy flavones, and containing volatile oil.
Turmeric：It is warm in nature, it is bitter, pungent.Returns spleen warp, Liver Channel.It is blood-breaking, inducing meastruation to relieve menalgia.The blood-activating analgesic of category drug for invigorating blood circulation and eliminating stasis subordinate's classification.Stop stomachache, traumatic injury, carbuncle swells etc. with trusted subordinate feeling of fullness distending pain, Disorder lumps in the abdomen, women's blood stasis is through closing, the postpartum stasis of blood is controlled.Mainly contain volatile oil and phenolic substance.Volatile oil has identified 51 kinds of compositions, based on terpenoid, mainly there is turmerone, zingerene etc.;Phenolic constituent mainly has curcumin etc..Using the colorimetric method for determining curcumin of thin layer one, the content of demethoxycurcumin and bisdemethoxycurcumin, and application Curcuma By Tlc-scanning Densitometry element content.Pharmacological research shows that this product has liver protection, cholagogic, antibacterial, anti-inflammatory, antitumor, anti-AIDS, antifertility, reducing blood lipid etc. to act on.
Airpotato yam：It is mild-natured, bitter.Return liver warp, the heart channel of Hang-Shaoyin.Heat-clearing, cool blood, detoxify, disappear goitre.The heat-clearing and detoxifying drug of category antipyretic subordinate's classification.With controlling abscess of throat, carbuncle sore tumefacting virus, snake bite and insect sting, goitre.External application is smash to apply or grind and dresses affected part.Containing a small amount of Dioscin, the Chinese yam poison furans demethyl diterpene-kind compound such as saponin(e and diosbulbin A, diosbulbin B, diosbulbin C.Thyroid Gland Swell or thyroid adenoma clinically are treated with airpotato yam tincture, compound airpotato yam medicinal extract piece, airpotato yam plain piece, there is certain curative effect, wherein preferable with compound airpotato yam medicinal extract piece (containing KI) curative effect.There is certain inhibitory action to thyroid gland, esophagus, stomach and rectum, malignant tumor of breast, have inhibitory action to common skin fungi.
The fruit of Chinese magnoliavine：It is warm in nature, it is sour, sweet.Return lung warp, the heart channel of Hang-Shaoyin, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, kidney calming.Lung-intestine astringent medicinal under category astringent medicinal classification.Breathed heavily with void of coughing long is controlled, emission, enuresis frequent micturition, endless diarrhea, spontaneous sweating, injury thirst, Heat Diabetes, palpitation and insomnia.Fruit contains various lignanoids, also containing volatile oil, the influence to central stimulant pentylenetetrazole and strychnine median lethal dose.Benevolence contains wuweizisu A, B, C, wuweizi alcohol A and wuweizi alcohol B [17].It has been reported that fruit of Chinese magnoliavine decoction is injected intravenously, to normal rabbit and mostly there is respiratory stimulant to act on, absorption deepened, accelerated, and the respiration inhibition of anti-morphine ab can be acted on, tincture also have effect same.
The capsule of weeping forsythia：Cold nature, bitter.Return lung warp, the heart channel of Hang-Shaoyin, small intestinl channel.Clearing heat and detoxicating, dispersing swelling and dissipating binds.The heat-clearing and detoxifying drug of category antipyretic subordinate's classification.With control ulcer, scrofula, acute mastitis, erysipelas, anemopyretic cold, warm disease from the beginning of, warm join the army, hyperpyrexia polydipsia, coma send out spot, heat gonorrhea renal shutdown.Containing compounds such as lignanoids, flavonoids, volatile ingredient, vinylbenzene class, cyclohexyl alcohols, triterpenes and Coumarinses.Wherein betulinic acid, forsythin, arctiin, arhat rosin glycosides, rosin element, Forsythinol glycosides C, Forsythinol glycosides D etc. have important antibacterial and antivirus action.Major function has：The effect of antibacterial, antiviral, anti-inflammatory, antipyretic, liver protection, cardiac stimulant diuresis, preventing or arresting vomiting, step-down and citrin sample.
The root of Dahurain angelica：It is warm in nature, taste is pungent.Return stomach, large intestine channel, lung channel.Dissipate wind dehumidifying, sensible analgesic, detumescence and apocenosis.The warm-pungent diaphoretic drug of category diaphoretic medicine subordinate's classification.With headache, pain in the supra-orbital bone, nasal obstruction, nasosinusitis, toothache, leukorrhea, the sore swell and ache curative of curing cold.There is preferable analgesic effect, especially have good effect to headache etc., and have removing toxic substances, antiinflammation.It has recently been found that having dilating effect to heart coronary artery, it is contemplated that with controlling coronary heart disease.Containing volatile oil.In volatile oil detect 29 kinds of compounds, content it is higher have methyl ring certain herbaceous plants with big flowers alkane, tetradecene, ethyl laurate.Also contain several furocoumarins.Methanolic extract has radiation resistance.Water decoction also has inhibitory action to various bacteria such as Escherichia coli, S. sonnei, proteus, typhoid bacillus, paratyphosum Bacterium, Pseudomonas aeruginosa, cholera bacilli etc..Also there is inhibitory action to Bacillus tuberculosis.
Perilla leaf：Relieving exterior syndrome and dispelling cold, relieving QI stagnancy in the stomach.For anemofrigid cold, cough evil of vomitting, the vomiting of pregnancy, fish and crab poisoning.In having functions that expelling cold and relieving exterior syndrome, promoting the circulation of qi are wide.Perilla leaf can expand capillary, stimulate sweat secretion and sweating, and its immersion liquid infected by influenza has inhibitory action.Perilla leaf, with boiling, has and is acted on stomach cold dispelling with polished rice.For weak baby, to being under the weather, the easy person of catching a cold is effective.
The wind-weed：It is cold in nature, it is bitter, sweet.Return lung warp, stomach, kidney channel.Clearing heat-fire, fluid dryness.The heat-clearing and fire-clearing drug of category antipyretic subordinate's classification.With controlling fever caused by exogenous pathogenic factors, hyperpyrexia polydipsia, lung-heat type cough, osteopyrexia and fever, Heat Diabetes, dry constipation of intestines.Containing various saponin(es.Still containing choline, nicotinic acid, pantothenic acid Yi Ji Mang fruit glycosides.Pharmacological research thinks there is antipyretic, analgesia, anti-inflammatory and diuresis.
Chinese prickly ash：It is warm in nature, taste is pungent.Returns spleen warp, stomach, kidney channel.Warm in pain, desinsection are antipruritic.Category drugs for dispelling internal cold.With controlling coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to enterositosis, ascariasis etc.;Eczema itch are controlled in external application.Containing volatile oil, limonene, cumic alcohol, Geraniol etc. are contained in oil.Pharmacological evaluation shows that pericarp parenteral solution has analgesic, anesthetic effect;Geraniol can cause intestine in vitro to be wriggled in a small amount, largely then be allowed to suppress;Water decoction has inhibitory action to streptococcus, staphylococcus, pneumococcus, bacillus anthracis, hay bacillus, comma bacillus, paratyphosum Bacterium and Pseudomonas aeruginosa;Contained volatile oil can make roundworm, pinworm be poisoned.
Setose thistle：It is cool in nature, sweet, hardship.Thoughts of returning home warp, Liver Channel.Cooling blood and hemostasis, eliminating stasis to resolve swelling.The blood-cooling hemostatic of category hemostatic subordinate's classification.External application fresh goods is appropriate, smashes deposited.With control bleeding from five sense organs or subcutaneous tissue, haematemesis, hematuria, have blood in stool, metrostaxis, traumatism and bleeding, carbuncle sore tumefacting virus.Fresh leaf contains 6- methoxyl groups pectolinarin, 6,4 ' one dimethoxy baicalein -7- rhamnoglucosides.And containing Linaria vulgaris element, 5,7- dihydroxy -6,4 ' one dimethoxy flavones.It is reported that the aobvious alkaloid of herb and volatile oil reaction.With the effect such as hypotensive, antibacterial, there is inhibitory action to meningococcus, corynebacterium diphtheriae.
The Radix Astragali：Slightly warm in nature, it is sweet.Returns spleen warp, lung channel.Invigorating qi for strengthening superficies, diuresis, pus draining and toxin expelling, myogenic.The Qi-tonifying drug of category qi-restoratives medicine subordinate's classification.Treatment shortness of breath palpitations, weak, collapse, spontaneous perspiration, night sweat, physically weak edema, chronic nephritis, chronic diarrhea, prolapse of the anus, the prolapse of uterus, ulcer is difficult to burst, the long disunion of the open sore part, children's bronchus asthma, chronic hepatitis B, chronic nephritis and vital myocarditis.Use is preferably processed in tonifying Qi, and hidroschesis, diuresis, pus draining and toxin expelling myogenic preferably give birth to use.Mainly containing compositions such as triterpenoid saponin, flavones and polysaccharide.Water decoction tool adjusts immune, anti-aging and anti-stress effect.
Curcuma zedoary：It is warm in nature, taste is pungent, hardship.Returns spleen warp, Liver Channel.Promoting the circulation of qi blood-breaking, Xiao Ji Zhi Tong.Belong to the medicinal for breaking blood stasis and eliminating mass of drug for invigorating blood circulation and eliminating stasis subordinate.For Zhi Liao abdominal lump of mass in abdomen, blood stasis closed, dyspepsia distending pain, early cervical carcinoma.Containing volatile oil.Clinic zedoary oil injection drip-feed treatment Buerger's disease obtains good therapeutic effect, has good therapeutic effect and has no side effect to baby's RSV pneumonia.Oil formulation has antitumor action, and treatment oophoroma, malignant lymphoma, lung cancer, liver cancer have certain curative effect.
Folium isatidis：It is cold in nature, bitter.Thoughts of returning home warp, stomach.The clear spot of clearing heat and detoxicating, cool blood.The heat-clearing and detoxifying drug classified under category antipyretic.With control warm disease, blood-head send out spot, high fever do not move back and blood-heat bleeding top haemorrhage etc..Containing the mountain cyrtophyllin of flavonoid glycoside one, there are diuresis to rat, have obvious antiinflammatory action to rat egg white " arthritis " and dextran " arthritis ".Additionally, also containing the composition such as indigo yulan, indigo.
Sargent gloryvine：Hardship, puts down.Return large intestine channel, Liver Channel.It is clearing heat and detoxicating, promoting blood circulation, wind-dispelling.For abdominalgia with intestinal abscess, closed dysmenorrhea, arthralgia pain due to rheumatism, tumbling and swelling.
Madder：It is cold in nature, bitter.Return liver warp.Cool blood, hemostasis, dissolving stasis, stimulate the menstrual flow.The blood-cooling hemostatic classified under category hemostatic.Take decoct soup orally, or enter ball and dissipate, treatment haematemesis, bleeding from five sense organs or subcutaneous tissue, uterine bleeding, traumatism and bleeding, the resistance of Amenorrhea block up, joint pain, tumbling and swelling.Deficiency-cold in spleen and stomach and avoid clothes without the stagnant person of the stasis of blood.Containing compositions such as purple alizarin, alizarin, madder colors.Mouse oral root decoction has obvious cough-relieving and a phlegm-dispelling functions, but after adding alcohol precipitation, filtrate is invalid;Root decoction can resist the contraction of isolated rabbit ileum;Root water extract has excitation to isolated guinea-pig uterus, and puerpera orally also has the uterotonic effect of reinforcement;The immersion liquid of root temperature can expand frog foot web film blood vessel, and can slightly shorten the blood coagulation time of rabbit;Root in vitro has certain inhibitory action to golden yellow and staphylococcus albus, pneumococcus and Bacillus influenzae etc..
Peppermint：It is cool in nature, taste is pungent.Return lung warp, Liver Channel.Dispelling wind-heat, refresh oneself, promoting eruption.The cold-pungent and diaphoretic drugs of category diaphoretic medicine subordinate's classification.With the wind-heat that cures cold, headache, hot eyes, red swelling and pain of throat, pruitus, measles without adequate eruption etc..This product fragrance is pungent to be dissipated, sweating gas consumption, therefore body void hidrosis person should not use.Mainly contain volatile oil in peppermint,《Pharmacopoeia of People's Republic of China》Regulation this product volatile oil content must not be less than 0.80% (ml/g).With sweating, it is antipyretic, alleviate gastrointestinal smooth muscle spasmus, promote respiratory tract glandular secretion and have the effect such as anti-inflammatory and spasmolysis;Nerve endings cold receptor can also be stimulated and creeping chill is produced, and reversely caused the change of deep tissue blood vessel and played anti-inflammatory, analgesic, itching-relieving action to property;, Gram-negative coccus resistive to gram, bacillus and various viruses have certain inhibitory action.
Notopterygium root：It is warm in nature, taste is pungent, hardship.Return bladder warp, kidney channel.Relieving exterior syndrome and dispelling cold, dispelling wind and eliminating dampness, analgesic.The warm-pungent diaphoretic drug of category diaphoretic medicine subordinate's classification.With anemofrigid cold is controlled, have a headache Xiang Qiang, arthralgia pain due to rheumatism, aching pain in shoulder and back.Notopterygium root rhizome compound containing Coumarins, phenoloid, volatile oil (about 2.7%), fatty acid, amino acids, carbohydrate, notopterygium root also ferulic acid ester containing phenethyl.The under ground portion compound containing Coumarins of notopterygium forbesii, phenoloid, also glycoside containing cupreol and volatile oil.
Rattletop：Cold nature, taste is pungent, micro-sweet.Return lung warp, stomach.It is clearing heat and detoxicating, deliver promoting eruption.The cold-pungent and diaphoretic drugs classified under category diaphoretic medicine.With headache due to pathogenic wind-heat, heat toxin pharynx swelling, measles initial stage is controlled, hair is not smooth thoroughly.There is the cholesteric effect of reduction to the food hypercholesterolemia of rabbit, rat.
Radix bupleuri：Cold nature, bitter.Return liver warp, gallbladder channel.With in inducing diaphoresis, soothing the liver, rising Yang.The cold-pungent and diaphoretic drugs of category diaphoretic medicine subordinate's classification.With heating, fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation, the prolapse of uterus, the prolapse of the anus of curing cold.Root contains the compositions such as saponin(e, volatile oil bupleurumols, the another alcohol of Fu Shou containing spring.Pharmacological testing proves have antipyretic, anti-inflammatory, anti-liver injury, Antiradiation injury, antibacterial etc. to act on.
Rhizoma alismatis：It is cold in nature, it is sweet.Return kidney channel, bladder warp.Diuresis, clearing away damp-heat.The stranguria-relieving diuretic classified under category damp-clearing drug.With controlling difficult urination, oedema turgor, vomiting, rush down dysentery, phlegm and retained fluid, tinea pedis, gonorrhoea, hematuria etc..Containing various tetracyclic triterpene acetol derivatives, including alisol A, alisol B, alisol C and alisol A acid esters, alisol B acid esters, alisol C acid esters etc..And containing choline, lecithin and a kind of phospholipid material.Using high performance liquid chromatography, alisol A 24- acetates, the content of alisol B 23- acetates are determined.There are the pharmacological actions such as diuresis, regulation blood fat, the formation of anti-kidney stone, hypotensive, AFL, anti-nephritic activity.In the diuretic test of big white mouse, it is found that the rhizoma alismatis diuresis effect of winter product is big, raw rhizoma alismatis, wine are processed, bran fries rhizoma alismatis there are diuresis, and stir-baked RHIZOMA ALISMATIS with salt solution is without diuresis.
Chinese ephedra：It is warm in nature, taste is pungent, slight bitter.Return lung warp, bladder warp.Sweating cold dispelling, freeing lung and relieving asthma, inducing diuresis for removing edema.The warm-pungent diaphoretic drug of category diaphoretic medicine subordinate's classification.With control anemofrigid cold, it is uncomfortable in chest breath with cough, geomantic omen edema, bronchial astehma.It is multiplex control table disease solved, asthma and cough.Containing various alkaloids and volatility alkali benzylmethylamine etc..Wherein with ephedrine as principle active component, the 40% ~ 90% of TA amount is accounted for, separately containing Macro and microelements.Can stimulating central nervous system, also similar adrenergic effect；Energy antiallergy, infected by influenza has inhibitory action;There is refrigeration function；Chinese ephedra oil emu has analgesic activity and causes Muscle paralysis phenomenon, has inhibitory action to toad heart；Ephedine alkali can reduce blood pressure, and have diuresis.
Cassia twig：It is taste is pungent, sweet, it is warm in nature.Return bladder warp, the heart channel of Hang-Shaoyin, lung channel.Relieving muscles diaphoresis, warming meridians and promoting circulation of qi, helps yang transforming qi, flat gas that spins, belong to warm-pungent diaphoretic drug.Experiment shows, cinnaldehydrum is also anticonvulsion, antibacterial, antiviral, expansion of blood vessels and antiinflammatory action.With controlling anemofrigid cold, coldness and pain in the epigastrium, blood trembles with fear Amenorrhea, joint pain, phlegm and retained fluid, oedema, palpitaition, run quickly globefish.Containing volatile oil.Main component is cinnaldehydrum in oil, is calmness, analgesia, the active ingredient of refrigeration function.
It is windproof：It is warm in nature, it is sweet, pungent.Return bladder warp, Liver Channel, the spleen channel to deliver, wind-dispelling, dehumidifying.Classify warm-pungent diaphoretic drug under category diaphoretic medicine.The diseases such as treatment flu, headache, heating, lossless, arthralgia pain due to rheumatism, spasm of limbs, skin rheumatism itch, lockjaw.Containing volatile oil, there is 20 kinds of compounds in oil, content it is higher have octanal, β-bisabolence, Panaxynol (relative amount is 82.6%) contains the compositions such as chromone, cumarin, polyacetylene class, polysaccharide in addition.Windproof decoction or alcohol preserved material, to rabbit gavage or to rats by intraperitoneal injection, there is refrigeration function;To mouse stomach or abdominal cavity and the windproof decoction of hypodermic injection and alcohol preserved material, there is analgesic activity;Intramuscular injection n-butanol extract, it is possible to decrease rat blood viscosity;Windproof decoction, alcohol preserved material are gavaged or intraperitoneal administration, to rat, mouse tool antiinflammatory immunity function.Windproof decoction tool antibacterial, antivirus action.
Changshan：It is cold in nature, it is bitter, pungent.It is poisonous.Return lung warp, Liver Channel, the heart channel of Hang-Shaoyin.Preventing malaria, emetic therapy rob phlegm.Category emetic drug.Stop gathering with phlegm and retained fluid is controlled, chest diaphragm ruffian plug, malaria.The orixine third, Changshan of the first, febrifugine containing orixine time alkali, quinazolone, dichrin A, dichrin B and umbelliferone etc..Total extract has good therapeutic effect to the plasmodium falciparum and zoopery plasmodium of artificial culture.The anti-Amoeba effect of febrifugine is bigger than emetine 1 times.Animal experiment shows that orixine first, febrifugine, orixine third can reduce blood pressure.
Eupatorium：It is mild-natured, taste is pungent.Returns spleen warp, stomach, lung channel.Remove dampness by means of aromatics, appetizing of being amusing, deliver relieving summer-heat.Category damp-resolving medicinal.Multiplex sweet, halitosis in turbi damp obstructing in middle-JIAO, gastral cavity ruffian evil of vomitting, mouth, polysialia, summer-heat and damp table disease, the alliteration controlled is uncomfortable in chest.Containing volatile oil;Leaf contains coumarin, coumaric acid, thymohydroquinone;Root contains euparin.Popularity common cold virus has inhibitory action;And ovulation can be suppressed.
Stone reed：Possesses promoting diuresis for stranguria, the effects such as clearing lung-heat expels the heat-evil.Can be used to drench pain, hematuria, lithangiuria, ephritis, uterine bleeding, dysentery, cough with lung heat, chronic bronchitis, metal-inflicted wound, ulcer etc..
Ramulus Taxilli：It is bitter, sweet, it is mild-natured.Return liver warp, kidney channel.Filling liver kidney, strengthening the bones and muscles, wind-damp dispelling, antiabortive unit.The wind-damp dispelling strengthening the bones and muscles medicine of category medicine for rheumatism subordinate's classification.With controlling, arthralgia pain due to rheumatism, soreness and weakness of waist and knees, muscles and bones be powerless, uterine bleeding is through many, blood leaking in gestation, fetal irritability, hypertension.Containing flavone compound, predominantly auicularin, Quercetin and quercitin;Contain Hyperoside in leaf.Ramulus Taxilli water-leach liquor, the water-leach liquor of ethanol one and 30% alcohol leaching liquid have antihypertensive effect to anesthetized animal;Parenteral solution has diastole to act on normal and vibration guinea pig heart coronary vasodilator.Additionally, also having diuresis and an antivirus action.
Frutus cnidii：It is warm in nature, taste is pungent, hardship.Return kidney channel.Warming kidney and enhancing body, eliminating dampness, wind-dispelling, desinsection.Category desinsection antipruritic.With impotence, Gong Leng, cold-dampness under band, arthritis with fixed pain caused by dampness pain in the back is controlled, eczema of vulva, married woman's pruritus vulvae, trichomonas vaginitis are controlled outward.Tool sex hormone sample, relieving asthma, calm, local anaesthesia and the effect such as antimicrobial.Containing volatile oil, main component is dilute pinane, isovaleric acid borneol acetate, osthole, Columbianetin, bergapten, Osthole, isopimpinellin etc..
The fleece-flower root：It is warm in nature, it is bitter, sweet, puckery.Return liver warp, kidney channel, the heart channel of Hang-Shaoyin.Detoxify, the carbuncle that disappears, relax bowel.The antianaemics classified under category qi-restoratives medicine.Fleece-flower root tool anti-aging, enhancing are immunized, promote adrenocortical function.Haemocyte can be promoted newborn and development, regulation blood fat and antiatherosclerosis, and have hepatoprotective effect.With controlling scrofula sore carbuncle, rubella itch, dry constipation of intestines, high fat of blood.Containing anthraquinone analog compound, wherein rheum emodin -8-0-B-D- glucosides are one of active components of rush intelligence in the fleece-flower root;The 2-0-B-D- glucosides of 2,3,5,4- tetrahydroxystilbene of quinones composition Stibene-glucoside one have extensive cardiac vascular activity, immunological regulation, hepatoprotective effect etc., and amide compound has trans asafoetide acyl group -3- methyldopamines of Mu Ping horse pockets acid amides, N- etc.;Chromogen ketone has 7 monohydroxy .2,5. dimethyl chromone etc.;It is the active component of anti-aging, reducing blood lipid with Stibene-glucoside.Another 2,3,5,4- tetrahydroxystilbene -2-0- (6 "-O-a-D- glucopyranoses)-B-D- glucosides tool for containing suppresses vascular smooth muscle cell proliferation active function.
Chrysanthemum：Cold nature, sweet, hardship.Return lung warp, Liver Channel.Dissipate wind heat-clearing, flat liver improving eyesight.The cold-pungent and diaphoretic drugs of category diaphoretic medicine subordinate's classification.With controlling, anemopyretic cold, dizziness of having a headache, red eye, swell pain, eyes are dim-sighted.Containing adenine, choline, stachydrine, butterflybush flower glycosides etc..Deficiency of vital energy stomach cold, the disease of deficiency of food diarrhea, preferably uses it less.All deficiency of yang or headache and aversion to cold person avoids use.
The root of Beijing euphorbia：It is cold in nature, bitter.Return lung warp, the spleen channel, kidney channel.Water pouring drink, profit two are just.The drastically purgating water drug classified under category purgatives medicine.Application for the treatment of oedema due to chronic nephritis, ascites, phlegm and retained fluid, scrofula, swollen ulcer drug.Queen's delight ether extract has catharsis effect, and hot water extract has the play effect of rushing down to cat.The ethanol extract of root skin 70% is injected in animal, and blood pressure slightly rises, and kidney volume is reduced significantly, no matter dosage size, diuresis are notable.Health adult takes decoction also without obvious diuresis.Extract solution has dilating effect to peripheral vessel, can suppress adrenergic boosting.The root of Beijing euphorbia (the Euphorbia in northeast
Sp. after) fresh leaf juice in vitro has inhibitory action, but removing tannin to staphylococcus aureus and Pseudomonas aeruginosa, antibacterial action is to disappear, and preparation preserves a couple of days or heats can also make antibacterial action weaken even forfeiture.
Lilac daphne：It is bitter, pungent, temperature;It is poisonous.Return lung warp, the spleen channel, kidney channel.Removing water retention by purgation, detoxify desinsection.For oedema turgor, chest and abdomen ponding, phlegm and retained fluid accumulation, the circulation of vital energy in the wrong direction is breathed with cough, difficulty in urination and defecation;Control the mange favus of the scalp, pernio outward.
The radix paeoniae rubrathe：Cold nature, bitter.Return liver warp.Clearing heat and cooling blood, blood stasis removing analgesic.The heat-clearing drug of category antipyretic subordinate's classification.With control febrile virulent maculae, hematemesis and epistaxis, mesh support swell and ache, liver-depressed hypochondrium pain, closed dysmenorrhea, Disorder lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle swells sore.Containing Paeoniflorin, new Paeoniflorin, radix paeoniae rubrathe A prime, radix paeoniae rubrathe B prime and palmitic acid etc..Platelet aggregation of the extract in vitro to the induction of adrenaline, ADP, Trimeresurus and arachidonic acid has obvious inhibiting effect.Water decoction has compared with high inhibition effect to typhoid bacillus, shigella dysenteriae, staphylococcus aureus, hemolytic streptococcus etc. in vitro.N-butanol extract intraperitoneal injection has inhibitory action to mouse S-180 solid tumors.Because this product contains benzoic acid and phenols, other Chinese herbal medicines can be coordinated as the preservative of cosmetics.
Fringed pink：It is cold in nature, bitter.Thoughts of returning home warp, small intestinl channel.Inducing diuresis for treating strangurtia, blood-breaking are stimulated the menstrual flow.The stranguria-relieving diuretic of category damp-clearing drug subordinate's classification.With controlling heat gonorrhea, urolithiasis, urinary obstruction, drench the puckery pain of drip, menstruation apolipsis.Containing saponin(e, carbohydrate vitamin A sample material.Herb still contains a small amount of alkaloid.Pharmacological research shows there is diuresis, hypotensive.There is inhibitory action to staphylococcus aureus, Escherichia coli, typhoid bacillus, shigella flexneri, Pseudomonas aeruginosa.
Giant knotweed：Cold nature, mildly bitter flavor.Return liver warp, gallbladder channel, lung channel.It is expelling wind and removing dampness, blood stasis removing analgesic, relieving cough and reducing sputum.The damp-excreting anti-icteric medicinal classified under category damp-clearing drug.With controlling arthralgia, Amenorrhea, jaundice with damp-heat pathogen, chronic bronchitis, hyperlipemia, burn and scald, injury from falling down etc..Containing anthraquinone derivatives, according to analysis total amount up to 2.1010, based on sequestered (1.4%), mating type content is relatively low (0.6%).And containing stilbene compound resvertrol (i.e. resveratrol) and its glycosides resvertrol glycosides (i.e. polygonin) etc., containing a certain amount of tannin, multiple flavone compounds.Can use ultraviolet spectrophotometry, thin layer chromatography scanning, the content of rp-hplc determination resveratrol, or with the content of spectrophotometry general anthraquinone (must not be less than 1.5% in terms of rheum emodin).Pharmacological evaluation shows that this product can adjust blood fat, can delay the occurrence and development of atherosclerosis;And the blood of high fat of blood animal glutinous state high can be improved, and blood viscosity is recovered normal, prevent and treat formation and the Blood stasis of thrombus;And play the role of anti-liver injury, Hemorrhagic shock, antibacterial, antibechic, step-down, improvement microcirculation.
Flea stops：Cold nature, bitter.It is slightly poisonous.Return liver warp.Clearing heat and detoxicating, swelling and pain relieving, cool liver arresting convulsion.The heat-clearing and detoxifying drug of category antipyretic subordinate's classification.With controlling furunculosis carbuncle swells, abscess of throat, venomous snake bite, the pain of injury caused by falling and tumbling, convulsion.Suitable amount used externally, grinds and dresses.A containing chonglou saponin, chonglou saponin B, chonglou saponin C, chonglou saponin D, chonglou saponin E, chonglou saponin F, chonglou saponin G, chonglou saponin H, aglycon is Dioscin.Additionally, still containing several amino acids and sterone.Zoopery shows that water decoction has antibacterial antitussive action;Saponin fraction has antitumaous effect, and has analgesia and sedation.
Radix Angelicae Sinensis：It is warm in nature, it is sweet, pungent.Return liver warp, the heart channel of Hang-Shaoyin, the spleen channel.Replenishing and activating blood, menstruction regulating and pain relieving, relax bowel.The antianaemics of category qi-restoratives medicine subordinate's classification.With controlling blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, closed dysmenorrhea, asthenia cold abdominalgia, dry constipation of intestines, arthralgia pain due to rheumatism, injury from falling down, ulcer sores.Main component is Ligustilide, n-butene base Moo lactones and angelicone etc. in volatile oil.Still various trace elements containing vitamin B12 and iron, zinc etc..Can suppress in vitro animal uterus and excited whole animal uterus.Ligustilide has antiasthmatic effect to experimental animal, has inhibitory action to its central nervous system.Anti-anemia action effect may be relevant with the trace element such as contained vitamin B12 and iron, zinc.
The present invention prepares simple, and good absorbing effect, duration of efficacy is long, it is evident in efficacy, have no side effect, it is safe, low production cost, work fast strong with sterilizing ability, the remarkable advantage of good stability, it is adapted to the sterilizing of clinical laboratory and other section office of hospital, it is free from environmental pollution, it is non-stimulated to humans and animals, have no toxic side effect, be a kind of preferable germ killing drugs being worthy to be popularized.
（Four）Specific embodiment
Embodiment 1：
Take 25 grams of oriental wormwood,26 grams of galingal,26 grams of turmeric,25 grams of airpotato yam,25 grams of the fruit of Chinese magnoliavine,26 grams of the capsule of weeping forsythia,26 grams of the root of Dahurain angelica,25 grams of perilla leaf,24 grams of the wind-weed,26 grams of Chinese prickly ash,23 grams of setose thistle,26 grams of the Radix Astragali,25 grams of curcuma zedoary,25 grams of folium isatidis,26 grams of Sargent gloryvine,26 grams of madder,25 grams of peppermint,22 grams of notopterygium root,23 grams of rattletop,23 grams of radix bupleuri,26 grams of rhizoma alismatis,25 grams of Chinese ephedra,29 grams of cassia twig,Windproof 26 grams,25 grams of Changshan,26 grams of eupatorium,25 grams of stone reed,22 grams of Ramulus Taxilli,26 grams of frutus cnidii,25 grams of the fleece-flower root,26 grams of chrysanthemum,26 grams of the root of Beijing euphorbia,25 grams of lilac daphne,23 grams of the radix paeoniae rubrathe,26 grams of fringed pink,25 grams of giant knotweed,Flea stops 25 grams,25 grams of Radix Angelicae Sinensis,Decocted after above-mentioned Chinese medicine is cleaned,Filter residue,After cooling,According to 1:9 ratio mixes with 75% alcoholic solution, standing, filter residue after being well mixed, and using modern advanced pharmacy science and technology, is made sterilized washing lotion, as described clinical laboratory Chinese medicine sterilizing thimerosal.
Embodiment 2：
Take 10 grams of oriental wormwood,10 grams of galingal,11 grams of turmeric,12 grams of airpotato yam,10 grams of the fruit of Chinese magnoliavine,10 grams of the capsule of weeping forsythia,10 grams of the root of Dahurain angelica,10 grams of perilla leaf,10 grams of the wind-weed,10 grams of Chinese prickly ash,10 grams of setose thistle,10 grams of the Radix Astragali,10 grams of curcuma zedoary,10 grams of folium isatidis,10 grams of Sargent gloryvine,10 grams of madder,10 grams of peppermint,10 grams of notopterygium root,10 grams of rattletop,10 grams of radix bupleuri,10 grams of rhizoma alismatis,10 grams of Chinese ephedra,10 grams of cassia twig,Windproof 10 grams,10 grams of Changshan,10 grams of eupatorium,10 grams of stone reed,10 grams of Ramulus Taxilli,10 grams of frutus cnidii,10 grams of the fleece-flower root,10 grams of chrysanthemum,10 grams of the root of Beijing euphorbia,10 grams of lilac daphne,10 grams of the radix paeoniae rubrathe,10 grams of fringed pink,10 grams of giant knotweed,Flea stops 10 grams,10 grams of Radix Angelicae Sinensis,Decocted after above-mentioned Chinese medicine is cleaned,Filter residue,After cooling,According to 1:9 ratio mixes with 75% alcoholic solution, standing, filter residue after being well mixed, and using modern advanced pharmacy science and technology, is made sterilized washing lotion, as described clinical laboratory Chinese medicine sterilizing thimerosal.
Embodiment 3：
Take 20 grams of oriental wormwood,21 grams of galingal,20 grams of turmeric,21 grams of airpotato yam,22 grams of the fruit of Chinese magnoliavine,20 grams of the capsule of weeping forsythia,20 grams of the root of Dahurain angelica,21 grams of perilla leaf,19 grams of the wind-weed,20 grams of Chinese prickly ash,18 grams of setose thistle,18 grams of the Radix Astragali,19 grams of curcuma zedoary,21 grams of folium isatidis,21 grams of Sargent gloryvine,20 grams of madder,20 grams of peppermint,18 grams of notopterygium root,19 grams of rattletop,18 grams of radix bupleuri,19 grams of rhizoma alismatis,20 grams of Chinese ephedra,21 grams of cassia twig,Windproof 20 grams,20 grams of Changshan,19 grams of eupatorium,21 grams of stone reed,16 grams of Ramulus Taxilli,19 grams of frutus cnidii,18 grams of the fleece-flower root,21 grams of chrysanthemum,21 grams of the root of Beijing euphorbia,20 grams of lilac daphne,18 grams of the radix paeoniae rubrathe,19 grams of fringed pink,19 grams of giant knotweed,Flea stops 21 grams,20 grams of Radix Angelicae Sinensis,Decocted after above-mentioned Chinese medicine is cleaned,Filter residue,After cooling,According to 1:9 ratio mixes with 75% alcoholic solution, standing, filter residue after being well mixed, and using modern advanced pharmacy science and technology, is made sterilized washing lotion, as described clinical laboratory Chinese medicine sterilizing thimerosal.
Clinical trial：
1st, experimental strain：Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli.
2nd, bacterium culture medium：Nutrient agar and nutrient broth medium.
3rd, bacteriostatic experiment point experimental group and control group, experimental group is germ killing drugs of the present invention, and control group selects sodium chlorate thimerosal.
4th, specific experiment step：
（1）Prepare bacterium solution：Above-mentioned two groups of strains are inoculated on two agar mediums respectively, at 37 DEG C cultivate 24 hours, therefrom picking colonies typical is inoculated in two fresh nutrient broth mediums respectively respectively, it is synthermal under, cultivate 18 hours, it is standby；
（2）Germ killing drugs of the present invention and each 100ml of sodium chlorate thimerosal are taken respectively, is respectively placed in cut-back tank, dilute 20 times respectively to it, upper two kinds dilution liquors are split in two containers respectively, be placed under aseptic condition, it is standby；
（3）By above-mentioned steps（1）The experimental strain supported 18 hours through nutrition broth cultivation dilutes 100 times respectively with aseptic nutrient broth, and every kind of strain is sub-packed in two culture dishes, and control group and experimental group are marked respectively；
（4）By above-mentioned steps（2）The dilute solution of the thimerosal of the present invention of gained instills experimental group culture dish, and sodium chlorate thimerosal dilute solution instills control group culture dish.
5th, Germicidal efficacy measurement：
Observed above-mentioned experiment and measured strain revolution mark, concrete outcome such as upper table.
6th, after observation measurement is finished, above-mentioned culture dish is placed in stand three days under aseptic condition, Follow-up observation finds, control group bacterium colony continues to breed, and experimental group bacterium colony is unchanged.
7th, experimental result：
The sterilizing ability of experimental group is much larger than the sterilizing ability of control group, and can suppress strain continuation breeding.
Above is specific embodiment of the invention, is described further to technical scheme, but protection scope of the present invention is not limited to these embodiments.It is every to be included within protection scope of the present invention without departing substantially from the change of present inventive concept or equivalent substitute.
Claims (3)
1. a kind of clinical laboratory Chinese medicine sterilizing thimerosal, it is characterized by, the raw material composition and parts by weight for being made the effective ingredient are：10-25 grams of oriental wormwood,10-26 grams of galingal,11-26 grams of turmeric,12-25 grams of airpotato yam,10-25 grams of the fruit of Chinese magnoliavine,10-26 grams of the capsule of weeping forsythia,10-26 grams of the root of Dahurain angelica,10-25 grams of perilla leaf,10-24 grams of the wind-weed,10-26 grams of Chinese prickly ash,10-23 grams of setose thistle,10-26 grams of the Radix Astragali,10-25 grams of curcuma zedoary,10-25 grams of folium isatidis,10-26 grams of Sargent gloryvine,10-26 grams of madder,10-25 grams of peppermint,10-22 grams of notopterygium root,10-23 grams of rattletop,10-23 grams of radix bupleuri,10-26 grams of rhizoma alismatis,10-25 grams of Chinese ephedra,10-29 grams of cassia twig,Windproof 10-26 grams,10-25 grams of Changshan,10-26 grams of eupatorium,10-25 grams of stone reed,10-22 grams of Ramulus Taxilli,10-26 grams of frutus cnidii,10-25 grams of the fleece-flower root,10-26 grams of chrysanthemum,10-26 grams of the root of Beijing euphorbia,10-25 grams of lilac daphne,10-23 grams of the radix paeoniae rubrathe,10-26 grams of fringed pink,10-25 grams of giant knotweed,Flea stops 10-25 grams,10-25 grams of Radix Angelicae Sinensis.
2. a kind of clinical laboratory Chinese medicine sterilizing thimerosal according to claim 1, it is characterized by, the raw material composition and parts by weight for being made the effective ingredient are：10 grams of oriental wormwood, 10 grams of galingal, 11 grams of turmeric, 12 grams of airpotato yam, 10 grams of the fruit of Chinese magnoliavine, 10 grams of the capsule of weeping forsythia, 10 grams of the root of Dahurain angelica, 10 grams of perilla leaf, 10 grams of the wind-weed, 10 grams of Chinese prickly ash, 10 grams of setose thistle, 10 grams of the Radix Astragali, 10 grams of curcuma zedoary, 10 grams of folium isatidis, 10 grams of Sargent gloryvine, 10 grams of madder, 10 grams of peppermint, 10 grams of notopterygium root, 10 grams of rattletop, 10 grams of radix bupleuri, 10 grams of rhizoma alismatis, 10 grams of Chinese ephedra, 10 grams of cassia twig, windproof 10 grams, 10 grams of Changshan, 10 grams of eupatorium, 10 grams of stone reed, 10 grams of Ramulus Taxilli, 10 grams of frutus cnidii, 10 grams of the fleece-flower root, 10 grams of chrysanthemum, 10 grams of the root of Beijing euphorbia, 10 grams of lilac daphne, 10 grams of the radix paeoniae rubrathe, 10 grams of fringed pink, 10 grams of giant knotweed, flea stops 10 grams, 10 grams of Radix Angelicae Sinensis.
It is 3. according to claim 1 and 2 to control a kind of clinical laboratory Chinese medicine sterilizing thimerosal, it is characterised in that：It is described by above-mentioned Chinese medicine clean after decoct, filter residue, cool after, according to 1:9 ratio mixes with 75% alcoholic solution, standing, filter residue after being well mixed, and using modern advanced pharmacy science and technology, is made sterilized washing lotion, as described clinical laboratory Chinese medicine sterilizing thimerosal.
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| CN108498672A (en) * | 2018-05-04 | 2018-09-07 | 顾建花 | A kind of hospital's thimerosal and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108853268A (en) * | 2017-05-08 | 2018-11-23 | 郭传申 | A kind of department of general surgery's wound irrigation Chinese materia medica preparation |
| CN108853277A (en) * | 2017-05-12 | 2018-11-23 | 王月梅 | A kind of Traditional Chinese medicine disinfectant for acupuncture |
| CN107916574A (en) * | 2017-10-31 | 2018-04-17 | 南宁市致良行文化传播有限公司 | A kind of processing method of peacock feather |
| CN108498672A (en) * | 2018-05-04 | 2018-09-07 | 顾建花 | A kind of hospital's thimerosal and preparation method thereof |
| CN112006042A (en) * | 2020-09-04 | 2020-12-01 | 沣田宝农业科技有限公司 | Traditional Chinese medicine composition for disinfection, traditional Chinese medicine preparation, preparation method and application |
| CN113662017A (en) * | 2021-09-30 | 2021-11-19 | 西南大学 | Application of composite plant essential oil |
| CN113662017B (en) * | 2021-09-30 | 2022-07-01 | 西南大学 | Application of composite plant essential oil |
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