CN108498672A - A kind of hospital's thimerosal and preparation method thereof - Google Patents
A kind of hospital's thimerosal and preparation method thereof Download PDFInfo
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- CN108498672A CN108498672A CN201810420250.9A CN201810420250A CN108498672A CN 108498672 A CN108498672 A CN 108498672A CN 201810420250 A CN201810420250 A CN 201810420250A CN 108498672 A CN108498672 A CN 108498672A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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Abstract
The invention discloses a kind of hospital's thimerosals and preparation method thereof, are made of following parts by weight：10 20g of scutellaria, 4 10g of Chinese lobelia, 6 12g of airpotato yam, 3 8g of the root of Dahurain angelica, 5 9g of Radix Astragali, 4 8g of peppermint, 3 5g of rhizoma alismatis, 4 12g of Chinese ephedra, 20 80g of radix bupleuri, 1 2g of frutus cnidii, 2 3g of eupatorium, 4 9g of honeysuckle, 5 10g of wild chrysanthemum, 3 8g of Fructus Forsythiae, 2 9g of folium artemisiae argyi, hydrogen peroxide 4 8%, the tincture of iodine 2 5%, Iodophor 0.5 1%, various bacteriums etc. can effectively be killed, with broad spectrum activity, bactericidal effect is notable, the various bacterium between palm and webs can effectively be killed, it can effectively avoid the illness probability of patient or health care worker, both hands can be cleaned whenever and wherever possible, the Disinfection Effect duration is long, sustainable 46 hours, effectively reduce the cross-infection of public place.
Description
Technical field
The present invention relates to a kind of thimerosals, more particularly, to a kind of hospital's thimerosal and preparation method thereof.
Background technology
Hospital is the place for treating disease, simultaneously because medical sufferer carries more pathogen, is also carried for transmission
Condition is supplied.In doctor's physical examination, sample collection, checkout procedure, between medical worker and patient, medical worker and sample
Sheet, instrument, being in direct contact for equipment are all an important factor for causing cross-infection.In order to cut off bacterium, virus in the above process
In by the propagation of hand, medical worker needs often wash one's hands as required.It finds after testing, the hand bacterium of medical worker is mainly divided
Often to occupy two kinds of bacterium and tabernacle bacterium, often occupy bacterium can growth and breeding on the skin, and be not easy to be washed by rubbing with the hands friction remove it is clean, than as usual
Coagulase-negative staphylococci, rod-like stem mushroom for seeing etc..Tabernacle bacterium is the microorganism polluted temporarily at work, such as common
Gram-positive bacteria, Gram-negative bacteria and Respirovirus.Staphylococcus and enterococcus are common gram-positive bacterias,
Klebsiella is common Gram-negative bacteria.Investigation display, after medical worker nurses the sick, the staphylococcus that carries on hand and
Gram-Negative bacillus is up to tens million of a bacterium colonies, if continuing to nurse next patient without effective sterilizing,
It is just easy to pathogen transmission to other patients, so the cleaning of medical staff's hand and disinfection are extremely important.
Currently, thimerosal on the market is varied, but the antivirus effect for being directed to certain bacterium mostly is notable, bactericidal effect list
One, do not have broad-spectrum.Moreover, but much product is easy to will produce irritation to the hand skin of user using rear,
Especially when number of washing one's hands frequently or when used for a long time can damage the hand skin of user, cause user's hand skin dry
It is dry, be cracked, itch.Therefore, now there is an urgent need for a kind of hospital's thimerosals.
Invention content
A kind of technical problems based on background technology, hospital's thimerosal of present invention offer and preparation method thereof, disappear
Toxic effect fruit is good, does not stimulate mildly, and stability is good, and environmental pollution degree is low.
The root of radix scutellariae is used as medicine, bitter, cold in nature, there is heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, tocolysis and other effects.Cure mainly warm
Disease, the infection of the upper respiratory tract, cough with lung heat, neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, carbuncle swells furuncle
The diseases such as sore.The clinical antibiotic property of radix scutellariae is better than the coptis, and does not develop immunity to drugs.
Chinese lobelia, Campanulaceae lobelia perennial herb.Stem is thin and delicate, crawls, and takes root on section, and branch is upright.Leaf alternate,
Stockless or nearly stockless, ellipticity lanceolar to bar shaped.There is the benefits of clearing heat and detoxicating, inducing diuresis to remove edema, controls venomous snake bite, hepatic sclerosis abdomen
Water, advanced schistosomiasis ascites, appendicitis and other effects.
Peppermint is Chinese conventional Chinese medicine, and young tender stem tip can make vegetable edible, and herb can be used as medicine again, and cure cold fever laryngalgia, headache,
Conjunctival congestion with ophthalmalgia, myalgia, itchy skin with rubella, the diseases such as measles without adequate eruption are also effective to carbuncle, subcutaneous ulcer, scabies, tinea, dermatitis rhus in addition.Peppermint contains
Have menthol, the substance can fresh breath and have a variety of pharmacological properties, abdominal pain, gall-bladder problem such as spasm can be alleviated, also have anti-corrosion
Sterilization, diuresis, resolving sputum, stomach invigorating and aid digestion and other effects.
The present inventor, by continuously improving formula, develops hospital's thimerosal, especially on a large amount of practical basis
Scutellaria, Chinese lobelia and the addition of peppermint have the effect of unexpected.
Technical scheme is as follows：
A kind of hospital's thimerosal, is made of following parts by weight：Scutellaria 10-20g, Chinese lobelia 4-10g, airpotato yam 6-12g, the root of Dahurain angelica
3-8g, Radix Astragali 5-9g, peppermint 4-8g, rhizoma alismatis 3-5g, Chinese ephedra 4-12g, radix bupleuri 20-80g, frutus cnidii 1-2g, eupatorium 2-3g, gold and silver
Flower 4-9g, wild chrysanthemum 5-10g, Fructus Forsythiae 3-8g, folium artemisiae argyi 2-9g, hydrogen peroxide 4-8%, tincture of iodine 2-5%, Iodophor 0.5-1%.
As a preferred technical solution of the present invention, it is made of following parts by weight：Scutellaria 10g, Chinese lobelia 10g, xanthate
Sub- 6g, root of Dahurain angelica 3g, Radix Astragali 9g, peppermint 4g, rhizoma alismatis 5g, Chinese ephedra 4g, radix bupleuri 80g, frutus cnidii 1g, eupatorium 3g, honeysuckle 4g, mother chrysanthemum
Flower 10g, Fructus Forsythiae 3g, folium artemisiae argyi 9g, hydrogen peroxide 4%, the tincture of iodine 5%, Iodophor 0.5%.
As a preferred technical solution of the present invention, it is made of following parts by weight：Scutellaria 12g, Chinese lobelia 6g, airpotato yam
8g, root of Dahurain angelica 4g, Radix Astragali 6g, peppermint 5g, rhizoma alismatis 4g, Chinese ephedra 6g, radix bupleuri 40g, frutus cnidii 1g, eupatorium 2g, honeysuckle 5g, wild chrysanthemum
6g, Fructus Forsythiae 4g, folium artemisiae argyi 4g, hydrogen peroxide 5%, the tincture of iodine 3%, Iodophor 0.5%.
As a preferred technical solution of the present invention, it is made of following parts by weight：Scutellaria 15g, Chinese lobelia 7g, airpotato yam
9g, root of Dahurain angelica 5g, Radix Astragali 7g, peppermint 6g, rhizoma alismatis 4g, Chinese ephedra 8g, radix bupleuri 50g, frutus cnidii 2g, eupatorium 2g, honeysuckle 6g, wild chrysanthemum
7g, Fructus Forsythiae 5g, folium artemisiae argyi 5g, hydrogen peroxide 6%, the tincture of iodine 4%, Iodophor 0.5%.
A kind of hospital's thimerosal, is prepared by the following method：
（1）It weighs：
Above-mentioned Chinese medicine material is got out, above-mentioned Chinese medicine is weighed to come one by one according to parts by weight；
（2）Washing：
By load weighted Chinese medicine material washes clean, dry；
（3）It is broken：
The Chinese medicine material of wash clean is placed on inside crusher and is pulverized；
（4）It decocts：
Chinese medicine material after pulverizing is put into equipment for decocting Chinese traditional herb medicines and is added water to cook, decocts 10-30 minutes, filters out extracting solution；
（5）Secondary decoction：
The topped up with water into extracting solution decocts 10-30 minutes, filters out extracting solution again；
（6）Hybrid filtering：
It extracting solution will mix twice, and filter again, obtain mixed liquor, stand, cool；
（7）Mixed alcohol：
By the mixed liquor after cooling according to 1:8 ratio and alcoholic solution mixing, filter residue, is added said ratio after mixing
Hydrogen peroxide, the tincture of iodine, Iodophor are uniformly mixed, and obtain product.
As a preferred technical solution of the present invention, the alcohol is the alcohol of 75% concentration.
The invention has the beneficial effects that：
1, hospital's thimerosal of the present invention can effectively kill various bacteriums etc., have broad spectrum activity, bactericidal effect is notable, can be effective
Kill the various bacterium between palm and webs, such as Candida albicans, staphylococcus, corynebacteria, Klebsiella, large intestine bar in ground
Bacterium, saccharomytes, can effectively avoid the illness probability of patient or health care worker, can clean whenever and wherever possible double
Hand, the Disinfection Effect duration is long, 4-6 hours sustainable, effectively reduces the cross-infection of public place.
2, hospital's thimerosal of the present invention, by plurality of raw materials mix and match, scientific composition, each raw material has complementary advantages, and utilizes
Moisturizing skin care ingredient is added in its mutual collaboration or resistant function, reduces the stimulation to skin, and nourishes rough skin is protected
It holds hand to moisten, product property is mild, nontoxic to normal skin non-stimulated, safe and efficient.
Specific implementation mode
The present invention is described further with reference to embodiment：
Embodiment 1：
A kind of hospital's thimerosal, is made of following parts by weight：Scutellaria 10g, Chinese lobelia 10g, airpotato yam 6g, root of Dahurain angelica 3g, Radix Astragali
9g, peppermint 4g, rhizoma alismatis 5g, Chinese ephedra 4g, radix bupleuri 80g, frutus cnidii 1g, eupatorium 3g, honeysuckle 4g, wild chrysanthemum 10g, Fructus Forsythiae 3g, Chinese mugwort
Leaf 9g, hydrogen peroxide 4%, the tincture of iodine 5%, Iodophor 0.5%.
It is prepared by the following method：
（1）It weighs：
Above-mentioned Chinese medicine material is got out, above-mentioned Chinese medicine is weighed to come one by one according to parts by weight；
（2）Washing：
By load weighted Chinese medicine material washes clean, dry；
（3）It is broken：
The Chinese medicine material of wash clean is placed on inside crusher and is pulverized；
（4）It decocts：
Chinese medicine material after pulverizing is put into equipment for decocting Chinese traditional herb medicines and is added water to cook, decocts 10 minutes, filters out extracting solution；
（5）Secondary decoction：
The topped up with water into extracting solution decocts 10 minutes, filters out extracting solution again；
（6）Hybrid filtering：
It extracting solution will mix twice, and filter again, obtain mixed liquor, stand, cool；
（7）Mixed alcohol：
By the mixed liquor after cooling according to 1:8 ratio and alcoholic solution mixing, filter residue, is added said ratio after mixing
Hydrogen peroxide, the tincture of iodine, Iodophor are uniformly mixed, and obtain product.
Embodiment 2：
A kind of hospital's thimerosal, is made of following parts by weight：Scutellaria 12g, Chinese lobelia 6g, airpotato yam 8g, root of Dahurain angelica 4g, Radix Astragali
6g, peppermint 5g, rhizoma alismatis 4g, Chinese ephedra 6g, radix bupleuri 40g, frutus cnidii 1g, eupatorium 2g, honeysuckle 5g, wild chrysanthemum 6g, Fructus Forsythiae 4g, folium artemisiae argyi
4g, hydrogen peroxide 5%, the tincture of iodine 3%, Iodophor 0.5%.
It is prepared by the following method：
（1）It weighs：
Above-mentioned Chinese medicine material is got out, above-mentioned Chinese medicine is weighed to come one by one according to parts by weight；
（2）Washing：
By load weighted Chinese medicine material washes clean, dry；
（3）It is broken：
The Chinese medicine material of wash clean is placed on inside crusher and is pulverized；
（4）It decocts：
Chinese medicine material after pulverizing is put into equipment for decocting Chinese traditional herb medicines and is added water to cook, decocts 15 minutes, filters out extracting solution；
（5）Secondary decoction：
The topped up with water into extracting solution decocts 15 minutes, filters out extracting solution again；
（6）Hybrid filtering：
It extracting solution will mix twice, and filter again, obtain mixed liquor, stand, cool；
（7）Mixed alcohol：
By the mixed liquor after cooling according to 1:8 ratio and alcoholic solution mixing, filter residue, is added said ratio after mixing
Hydrogen peroxide, the tincture of iodine, Iodophor are uniformly mixed, and obtain product.
Embodiment 3：
A kind of hospital's thimerosal, is made of following parts by weight：Scutellaria 15g, Chinese lobelia 7g, airpotato yam 9g, root of Dahurain angelica 5g, Radix Astragali
7g, peppermint 6g, rhizoma alismatis 4g, Chinese ephedra 8g, radix bupleuri 50g, frutus cnidii 2g, eupatorium 2g, honeysuckle 6g, wild chrysanthemum 7g, Fructus Forsythiae 5g, folium artemisiae argyi
5g, hydrogen peroxide 6%, the tincture of iodine 4%, Iodophor 0.5%.
It is prepared by the following method：
（1）It weighs：
Above-mentioned Chinese medicine material is got out, above-mentioned Chinese medicine is weighed to come one by one according to parts by weight；
（2）Washing：
By load weighted Chinese medicine material washes clean, dry；
（3）It is broken：
The Chinese medicine material of wash clean is placed on inside crusher and is pulverized；
（4）It decocts：
Chinese medicine material after pulverizing is put into equipment for decocting Chinese traditional herb medicines and is added water to cook, decocts 20 minutes, filters out extracting solution；
（5）Secondary decoction：
The topped up with water into extracting solution decocts 20 minutes, filters out extracting solution again；
（6）Hybrid filtering：
It extracting solution will mix twice, and filter again, obtain mixed liquor, stand, cool；
（7）Mixed alcohol：
By the mixed liquor after cooling according to 1:8 ratio and alcoholic solution mixing, filter residue, is added said ratio after mixing
Hydrogen peroxide, the tincture of iodine, Iodophor are uniformly mixed, and obtain product.
Embodiment 4：
A kind of hospital's thimerosal, is made of following parts by weight：Scutellaria 17g, Chinese lobelia 9g, airpotato yam 10g, root of Dahurain angelica 7g, Radix Astragali
8g, peppermint 7g, rhizoma alismatis 4g, Chinese ephedra 10g, radix bupleuri 70g, frutus cnidii 2g, eupatorium 3g, honeysuckle 8g, wild chrysanthemum 8g, Fructus Forsythiae 7g, Chinese mugwort
Leaf 8g, hydrogen peroxide 8%, the tincture of iodine 4%, Iodophor 0.8%.
It is prepared by the following method：
（1）It weighs：
Above-mentioned Chinese medicine material is got out, above-mentioned Chinese medicine is weighed to come one by one according to parts by weight；
（2）Washing：
By load weighted Chinese medicine material washes clean, dry；
（3）It is broken：
The Chinese medicine material of wash clean is placed on inside crusher and is pulverized；
（4）It decocts：
Chinese medicine material after pulverizing is put into equipment for decocting Chinese traditional herb medicines and is added water to cook, decocts 20 minutes, filters out extracting solution；
（5）Secondary decoction：
The topped up with water into extracting solution decocts 20 minutes, filters out extracting solution again；
（6）Hybrid filtering：
It extracting solution will mix twice, and filter again, obtain mixed liquor, stand, cool；
（7）Mixed alcohol：
By the mixed liquor after cooling according to 1:8 ratio and alcoholic solution mixing, filter residue, is added said ratio after mixing
Hydrogen peroxide, the tincture of iodine, Iodophor are uniformly mixed, and obtain product.
Embodiment 5：
A kind of hospital's thimerosal, is made of following parts by weight：Scutellaria 20g, Chinese lobelia 4g, airpotato yam 12g, root of Dahurain angelica 3g, Radix Astragali
9g, peppermint 4g, rhizoma alismatis 5g, Chinese ephedra 4g, radix bupleuri 80g, frutus cnidii 1g, eupatorium 3g, honeysuckle 4g, wild chrysanthemum 10g, Fructus Forsythiae 3g, Chinese mugwort
Leaf 9g, hydrogen peroxide 4%, the tincture of iodine 5%, Iodophor 0.5%.
It is prepared by the following method：
（1）It weighs：
Above-mentioned Chinese medicine material is got out, above-mentioned Chinese medicine is weighed to come one by one according to parts by weight；
（2）Washing：
By load weighted Chinese medicine material washes clean, dry；
（3）It is broken：
The Chinese medicine material of wash clean is placed on inside crusher and is pulverized；
（4）It decocts：
Chinese medicine material after pulverizing is put into equipment for decocting Chinese traditional herb medicines and is added water to cook, decocts 20 minutes, filters out extracting solution；
（5）Secondary decoction：
The topped up with water into extracting solution decocts 20 minutes, filters out extracting solution again；
（6）Hybrid filtering：
It extracting solution will mix twice, and filter again, obtain mixed liquor, stand, cool；
（7）Mixed alcohol：
By the mixed liquor after cooling according to 1:8 ratio and alcoholic solution mixing, filter residue, is added said ratio after mixing
Hydrogen peroxide, the tincture of iodine, Iodophor are uniformly mixed, and obtain product.
Comparative example 1：
This comparative example is a kind of Medical antiseptic solution in the market.
Correlated performance is carried out according to the traditional test methods of this field to the product prepared by above example and comparative example
Test, test result is as follows shown in table：
By upper table it is found that it is provided by the invention it is medical with thimerosal can quick sterilization, to Escherichia coli, Candida albicans,
The average killing logarithm of White staphylococcus is respectively higher than 7.5,7.4 and 7.9, and the average killing logarithm for meeting country is higher than
5 regulation；In addition, the thimerosal of the present invention is non-stimulated and nontoxic, and it is safe to use, meet the application requirement of medical and health industry.
The foregoing is merely one embodiment of the invention, are not intended to limit the present invention, all to use equivalent substitution or equivalent transformation
The technical solution that is obtained of mode, all fall in protection scope of the present invention.
Claims (6)
1. a kind of hospital's thimerosal, which is characterized in that be made of following parts by weight：Scutellaria 10-20g, Chinese lobelia 4-10g, Huang
Medicine 6-12g, root of Dahurain angelica 3-8g, Radix Astragali 5-9g, peppermint 4-8g, rhizoma alismatis 3-5g, Chinese ephedra 4-12g, radix bupleuri 20-80g, frutus cnidii 1-
2g, eupatorium 2-3g, honeysuckle 4-9g, wild chrysanthemum 5-10g, Fructus Forsythiae 3-8g, folium artemisiae argyi 2-9g, hydrogen peroxide 4-8%, tincture of iodine 2-5%, Iodophor
0.5-1%。
2. a kind of hospital's thimerosal according to claim 1, which is characterized in that be made of following parts by weight：Scutellaria
10g, it Chinese lobelia 10g, airpotato yam 6g, root of Dahurain angelica 3g, Radix Astragali 9g, peppermint 4g, rhizoma alismatis 5g, Chinese ephedra 4g, radix bupleuri 80g, frutus cnidii 1g, wears
Blue 3g, honeysuckle 4g, wild chrysanthemum 10g, Fructus Forsythiae 3g, folium artemisiae argyi 9g, hydrogen peroxide 4%, the tincture of iodine 5%, Iodophor 0.5%.
3. a kind of hospital's thimerosal according to claim 1, which is characterized in that be made of following parts by weight：Scutellaria
12g, it Chinese lobelia 6g, airpotato yam 8g, root of Dahurain angelica 4g, Radix Astragali 6g, peppermint 5g, rhizoma alismatis 4g, Chinese ephedra 6g, radix bupleuri 40g, frutus cnidii 1g, wears
Blue 2g, honeysuckle 5g, wild chrysanthemum 6g, Fructus Forsythiae 4g, folium artemisiae argyi 4g, hydrogen peroxide 5%, the tincture of iodine 3%, Iodophor 0.5%.
4. a kind of hospital's thimerosal according to claim 1, which is characterized in that be made of following parts by weight：Scutellaria
15g, it Chinese lobelia 7g, airpotato yam 9g, root of Dahurain angelica 5g, Radix Astragali 7g, peppermint 6g, rhizoma alismatis 4g, Chinese ephedra 8g, radix bupleuri 50g, frutus cnidii 2g, wears
Blue 2g, honeysuckle 6g, wild chrysanthemum 7g, Fructus Forsythiae 5g, folium artemisiae argyi 5g, hydrogen peroxide 6%, the tincture of iodine 4%, Iodophor 0.5%.
5. a kind of preparation method of hospital's thimerosal as described in claims 1-4, which is characterized in that it is by the following method
It is prepared：
(1) it weighs：
Above-mentioned Chinese medicine material is got out, above-mentioned Chinese medicine is weighed to come one by one according to parts by weight；
(2) it washs：
By load weighted Chinese medicine material washes clean, dry；
(3) it is crushed：
The Chinese medicine material of wash clean is placed on inside crusher and is pulverized；
(4) it decocts：
Chinese medicine material after pulverizing is put into equipment for decocting Chinese traditional herb medicines and is added water to cook, decocts 10-30 minutes, filters out extracting solution；
(5) secondary decoction：
The topped up with water into extracting solution decocts 10-30 minutes, filters out extracting solution again；
(6) hybrid filtering：
It extracting solution will mix twice, and filter again, obtain mixed liquor, stand, cool；
(7) mixed alcohol：
By the mixed liquor after cooling according to 1:8 ratio and alcoholic solution mixing, filter residue, is added said ratio after mixing
Hydrogen peroxide, the tincture of iodine, Iodophor are uniformly mixed, and obtain product.
6. a kind of preparation method of hospital's thimerosal according to claim 5, which is characterized in that the alcohol is
The alcohol of 75% concentration.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111437336A (en) * | 2020-05-27 | 2020-07-24 | 长沙医学院 | Traditional Chinese medicine iodine complex disinfectant |
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| CN104173548A (en) * | 2014-07-31 | 2014-12-03 | 青岛华承天机械制造有限公司 | Disinfectant containing Chinese herbal medicinal ingredients |
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| CN111437336A (en) * | 2020-05-27 | 2020-07-24 | 长沙医学院 | Traditional Chinese medicine iodine complex disinfectant |
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Application publication date: 20180907 |