CN111437336A - Traditional Chinese medicine iodine complex disinfectant - Google Patents

Traditional Chinese medicine iodine complex disinfectant Download PDF

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Publication number
CN111437336A
CN111437336A CN202010459422.0A CN202010459422A CN111437336A CN 111437336 A CN111437336 A CN 111437336A CN 202010459422 A CN202010459422 A CN 202010459422A CN 111437336 A CN111437336 A CN 111437336A
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iodine
traditional chinese
chinese medicine
disinfectant
complex
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何彬生
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Changsha Medical University
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K9/0012—Galenical forms characterised by the site of application
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention discloses a traditional Chinese medicine complex iodine disinfectant, which belongs to the technical field of medicines and comprises the following components: 20-35g of common cnidium fruit, 20-35g of cochinchina momordica seed, 20-35g of camphor, 48-52g of garlic, 48-52g of alum, 48-52g of golden larch bark, 8-12g of honeycomb, 1-3g of toad venom and 500ml of iodine solution. Compared with the prior art, the invention has the beneficial effects that: the traditional Chinese medicine complex iodine disinfectant reduces the concentration of complex iodine, adds a plurality of traditional Chinese medicines, expands antibacterial spectrum, enhances the bactericidal effect, can promote the regeneration of skin mucosa cells, accelerates the healing of wounds after infection and the like. Therefore, the traditional Chinese medicine complex iodine disinfectant is used as an iodine disinfectant, can maintain and enhance the excellent sterilization characteristic of iodine, has the characteristics of overcoming the irritation and corrosion of iodine, and the like, and is suitable for popularization and application.

Description

Traditional Chinese medicine iodine complex disinfectant
Technical Field
The invention belongs to the technical field of medicines, and relates to a traditional Chinese medicine complex iodine disinfectant.
Background
Iodine tincture is a mixture of free iodine and alcohol, and the principle of disinfection is the super-strong oxidation of free iodine atoms, which can destroy the cell membrane structure and protein molecules of pathogens. Iodine tincture has strong bactericidal effect, is generally used for disinfecting injection part skin or diminishing inflammation of early furuncle, but has strong irritation and corrosivity, so that after being used for disinfecting skin, iodine should be removed by wiping with 70% alcohol, and the iodine tincture is forbidden to be used for disinfecting mucous membrane or wound, otherwise severe pain and red swelling can be caused. Therefore, the reason for deiodination of iodine tincture is that the iodine tincture has strong irritation and corrosivity, and is allergic to iodine for some patients, and timely deiodination can prevent the iodine from causing allergy after use.
The complex iodine is a compound and is an amorphous complex formed by complexing iodine and a surfactant. But their complexing ability and solubilizing effect are less than ideal. The defects of common complex iodine in the prior art are yellow dyeing, stick slip, poor pasting of adhesive tapes, more foams, alcohol doping in some iodine, larger irritation and easy precipitation of common iodophor. Surfactants used in such products are for example: polyethylene glycol, nonylphenol polyoxyethylene ether, polyalcohol ether, polyvinyl alcohol, alkyl sulfonate, quaternary ammonium salt and the like. These surfactants act as carriers and solubilisers in iodophors, where a significant proportion of "iodine exists" and is not bactericidal and is wasted, leaving yellow and even burning skin on the skin.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine complex iodine disinfectant, which can maintain and enhance the excellent sterilization characteristic of iodine and has the characteristics of overcoming the irritation and corrosion of iodine tincture and the like.
The specific technical scheme is as follows:
a traditional Chinese medicine iodine complex disinfectant comprises the following components:
Figure BDA0002510426300000021
further, the composition comprises the following components:
Figure BDA0002510426300000022
the preparation method of the traditional Chinese medicine iodine complex disinfectant comprises the following steps:
step 1, accurately weighing each component according to the formula of the invention;
step 2, crushing fructus cnidii, semen momordicae, garlic, alum, golden larch bark, honeycomb, venenum bufonis and camphor into fine powder, taking the fructus cnidii, the semen momordicae, the garlic, the alum, the golden larch bark and the honeycomb, using water as a solvent, decocting for several times, rolling and filtering for later use;
and 3, adding 9-10ml of 50-60% ethanol into the toad venom, adding 90-100ml of 50-60% ethanol into the camphor to dissolve the toad venom, adding the dissolved 50-60% ethanol into the liquid medicine obtained in the step 2, concentrating the total amount to 500ml, and adding an iodine solution to 1000ml of the total amount.
Compared with the prior art, the invention has the beneficial effects that:
the traditional Chinese medicine complex iodine disinfectant reduces the concentration of complex iodine, adds a plurality of traditional Chinese medicines, expands antibacterial spectrum, enhances the bactericidal effect, can promote the regeneration of skin mucosa cells, accelerates the healing of wounds after infection and the like. Therefore, the traditional Chinese medicine complex iodine disinfectant is used as an iodine disinfectant, can maintain and enhance the excellent sterilization characteristic of iodine, has the characteristics of overcoming the irritation and corrosion of iodine, has the effects of sterilization and itching relieving, and is suitable for popularization and application.
Detailed Description
The technical solution of the present invention will be described in further detail with reference to specific examples.
The traditional Chinese medicine iodine complex disinfectant is brown yellow liquid and has fragrant gas. Can kill various bacteria and fungi including spore, and promote wound healing. Can be used for treating infection caused by various reasons. The administration route is external.
The main components have the effects:
cnidium monnieri (L.) Cuss, also known as wild carrot seed, is a dried mature fruit of Cnidium monnieri (L.) Makino of Umbelliferae, which is harvested in summer and autumn when mature, and is cleaned and dried in the sun.
The functional indications are as follows: dry dampness, dispel wind, kill parasites, warm kidney and strengthen yang. Can be used for treating sexual impotence, cold womb, leukorrhagia due to cold-dampness, and lumbago due to damp arthralgia; it can be used for treating vulval eczema, pudendal pruritus, and trichomonal vaginitis.
Semen Momordicae (academic name: Momodica cochinchinensis (L our.) Spreng.) is called separately, and includes semen Strychni (Chinese economic plant), glutinous rice fruit (Yunnan river mouth), mouse-pulled wax gourd, etc. perennial herbaceous vine with enlarged root.
The functional indications are as follows: dissipate nodulation and resolve swelling, counteract toxic pathogen and cure sore. Can be used for treating pyocutaneous disease, pyogenic infection, acute mastitis, scrofula, anal fistula, tinea, and tinea.
Camphor is a particulate material prepared by distilling and refining roots, stems, branches and leaves of Cinnamomum camphora (L.) Presl of Lauraceae.
The functional indications are as follows: coma due to febrile disease, sudden collapse due to central aversion, eruptive distention, vomiting, diarrhea, abdominal pain, tinea pedis due to cold-dampness, scabies, intractable tinea, alopecia, chilblain, ecthyma, scald due to water or fire, traumatic injury, toothache, and red eyes due to wind-fire.
The Garlic (English name Garlic; Latin name Allium sativum L.) is an underground bulb of Allium plant (Allium) of Liliaceae (L iliaceae), the whole plant of the Garlic has strong pungent Garlic odor, and the Garlic bulb, Garlic leaves (green Garlic or Garlic sprout) and flower stem (Garlic sprout) can be eaten as vegetables, not only can be used as flavoring, but also can be used as medicine, and are famous plants for both eating and eating medicine.
The functional indications are as follows: has broad-spectrum antibacterial, antibacterial and antiinflammatory effects, and has strong antiviral effect.
Alum is crystal extracted from alunite as mineral.
Dissolve phlegm, dry dampness, check diarrhea, stop bleeding, remove toxicity and kill parasites. Treating epilepsy, pharyngitis, acute and chronic saliva accumulation, hepatitis, jaundice, yellow swelling, gastric ulcer, duodenal ulcer, uterine prolapse, leucorrhea, dysentery, epistaxis, aphtha, sore, hemorrhoid, scabies, tinea, water, fire, and insect injury.
Golden larch bark, which is the dried root bark or near-root bark of the plant Pinus massoniana (Pseudolarix kamepferi Gord.) of Pinaceae. Peeled off in summer and dried in the sun.
The functional indications are as follows: killing parasites and relieving itching; it is indicated for scabies, tinea and pruritus.
Honeycomb, name of traditional Chinese medicine. Nests of the wasp family insect, hornet Polistes olivacea (DeGeer), Japanese Polistes japonica Saussure or Heteroclita Parapolybia varicus Fabricius.
The functional indications are as follows: has the effects of counteracting toxic substances, killing parasites, dispelling pathogenic wind and relieving pain. It is commonly used for sores, ulcers, abscess, mastitis, scrofula, intractable tinea, fungal infection of hand and foot, toothache, rheumatism and arthralgia.
Toad venom is secretion of the posterior auricular gland and epidermal glands of toad, and is white milky liquid or light yellow liquid, which is toxic. The Bufonis venenum extract is prepared by extracting slurry of Bufonis venenum, drying, coloring, sealing, and storing.
The functional indications are as follows: resolving food stagnation, killing parasite, removing toxic substance, relieving swelling, tonifying heart, and relieving pain.
The complex iodine is a compound and is an amorphous complex formed by complexing iodine and a surfactant.
The main effects are as follows: can kill intestinal pathogenic bacteria, pyogenic coccus and pathogenic yeast, and bacteria common in hospital infection.
Example 1
A traditional Chinese medicine iodine complex disinfectant comprises the following components:
Figure BDA0002510426300000051
the preparation method of the traditional Chinese medicine iodine complex disinfectant comprises the following steps:
step 1, accurately weighing each component according to the formula of the invention;
step 2, crushing fructus cnidii, semen momordicae, garlic, alum, golden larch bark, honeycomb, venenum bufonis and camphor into fine powder, taking the fructus cnidii, the semen momordicae, the garlic, the alum, the golden larch bark and the honeycomb, using water as a solvent, decocting for several times, rolling and filtering for later use;
and 3, adding 9ml of 50% ethanol into the toad venom, adding 90ml of 50% ethanol into the camphor to dissolve the toad venom, adding the dissolved 50% ethanol into the liquid medicine obtained in the step 2, concentrating the total amount to 500ml, and adding an iodine solution to 1000ml of the total amount.
Example 2
A traditional Chinese medicine iodine complex disinfectant comprises the following components:
Figure BDA0002510426300000061
the preparation method of the traditional Chinese medicine iodine complex disinfectant comprises the following steps:
step 1, accurately weighing each component according to the formula of the invention;
step 2, crushing fructus cnidii, semen momordicae, garlic, alum, golden larch bark, honeycomb, venenum bufonis and camphor into fine powder, taking the fructus cnidii, the semen momordicae, the garlic, the alum, the golden larch bark and the honeycomb, using water as a solvent, decocting for several times, rolling and filtering for later use;
and 3, adding 10ml of 50% ethanol into the toad venom, adding 90ml of 50% ethanol into the camphor to dissolve the toad venom, adding the dissolved 50% ethanol into the liquid medicine obtained in the step 2, concentrating the total amount to 500ml, and adding an iodine solution to 1000ml of the total amount.
Example 3
A traditional Chinese medicine iodine complex disinfectant comprises the following components:
Figure BDA0002510426300000062
Figure BDA0002510426300000071
the preparation method of the traditional Chinese medicine iodine complex disinfectant comprises the following steps:
step 1, accurately weighing each component according to the formula of the invention;
step 2, crushing fructus cnidii, semen momordicae, garlic, alum, golden larch bark, honeycomb, venenum bufonis and camphor into fine powder, taking the fructus cnidii, the semen momordicae, the garlic, the alum, the golden larch bark and the honeycomb, using water as a solvent, decocting for several times, rolling and filtering for later use;
and 3, adding 10ml of 60% ethanol into the toad venom, adding 100ml of 60% ethanol into the camphor to dissolve the toad venom, adding the dissolved 60% ethanol into the liquid medicine obtained in the step 2, concentrating the total amount to 500ml, and adding an iodine solution to 1000ml of the total amount.
Comparative example
The observation group uses the traditional Chinese medicine complex iodine disinfectant with the formula of the invention, the control group uses the common complex iodine disinfectant to externally disinfect the skin of 40 patients, and the average value of the three repeated tests is shown in the following table 1.
TABLE 1 comparison of the sterilizing results of the traditional Chinese medicine complex iodine disinfectant and the common complex iodine disinfectant
Figure BDA0002510426300000072
The above description is only a preferred embodiment of the present invention, and the scope of the present invention is not limited thereto, and any simple modifications or equivalent substitutions of the technical solutions that can be obviously obtained by those skilled in the art within the technical scope of the present invention are within the scope of the present invention.

Claims (2)

1. The traditional Chinese medicine complex iodine disinfectant is characterized by comprising the following components:
Figure FDA0002510426290000011
2. the traditional Chinese medicine complex iodine disinfectant as claimed in claim 1, which comprises the following components:
Figure FDA0002510426290000012
CN202010459422.0A 2020-05-27 2020-05-27 Traditional Chinese medicine iodine complex disinfectant Pending CN111437336A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106668095A (en) * 2017-02-16 2017-05-17 广西万明堂生物科技有限公司 Dermatologic medicine for external use and preparation method thereof
CN108498672A (en) * 2018-05-04 2018-09-07 顾建花 A kind of hospital's thimerosal and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106668095A (en) * 2017-02-16 2017-05-17 广西万明堂生物科技有限公司 Dermatologic medicine for external use and preparation method thereof
CN108498672A (en) * 2018-05-04 2018-09-07 顾建花 A kind of hospital's thimerosal and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
董广民 主编: "《〈本草纲目〉中药养生速查全书》", 31 May 2015, 北京：中医古籍出版社 *

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