CN106214573A - A kind of medical disposable hand saver skin disinfectant solution and preparation method thereof - Google Patents
A kind of medical disposable hand saver skin disinfectant solution and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of medical disposable hand saver skin disinfectant solution and preparation method thereof.This medical disposable hand saver skin disinfectant solution, with hydrogen peroxide, tea tree oil, hyaluronic acid, mannitol, stearic acid, glycerol, triethanolamine, Kazon, p-Hydroxybenzoate, medical alcohol and Chinese medicine extraction liquid etc. as active component, compose according to a certain number of weight copies.This medical disposable hand saver skin disinfectant solution and preparation method thereof, disinfectant solution can kill the various antibacterials between palm and webs and virus quickly and effectively, and bactericidal effect is notable, and anhydrous hand cleaner, use and easy to carry, both hands can be cleaned whenever and wherever possible；PH value is close to the pH of skin, nontoxic non-stimulated to normal skin, safe and efficient.
Description
Technical field
The present invention relates to a kind of medical disposable hand saver skin disinfectant solution and preparation method thereof.
Background technology
Hospital is the place for the treatment of disease, simultaneously because medical sufferer carries more pathogen, also carries for pathophoresis
Supply condition.In doctor's physical examination, sample collection, checkout procedure, between medical worker and patient, medical worker and sample
Basis, instrument, the direct contact of equipment are all the key factors causing cross infection.In order to cut off antibacterial, virus at said process
In by the propagation of hand, medical worker needs the most often wash one's hands.Finding after testing, the hand antibacterial of medical worker is mainly divided
For often occupying bacterium and tabernacle bacterium two kinds, often occupying bacterium can breed at skin growths, and is difficult to be washed by rubbing with the hands friction removing totally, and ratio is as usual
The coagulase negative staphylococcus seen, rod-like stem mushroom etc..Tabernacle bacterium is the interim microorganism polluted at work, the most common
Gram positive bacteria, gram negative bacteria and Respirovirus.Staphylococcus and enterococcus are common gram positive bacterias,
Klebsiella is common gram negative bacteria.Investigation display, after medical worker nurses the sick, the golden yellow Fructus Vitis viniferae carried on hand
Coccus and gram negative bacilli are up to tens million of bacterium colonies, if not carrying out effective sterilizing to continue to the nursing next one
Patient, is just easy to pathogen transmission to other patients, so the cleaning of medical personnel's hands is extremely important with sterilization.
Handwashing liquid the most on the market is varied, but most virus killing effect for certain bacterium is notable, bactericidal effect list
One, do not possess broad-spectrum.And, but a lot of product easily can produce zest to the hand skin of user after using,
Especially the hand skin of user frequently or can be damaged during life-time service when number of times of washing one's hands, cause user hand skin to do
Dry, chap, itch.Therefore, the disposable handwashing liquid that a kind of bactericidal effect is good and non-stimulated to hand skin is now needed badly.
Summary of the invention
The present invention is in order to make up the deficiencies in the prior art, it is provided that one is easy to use, sterilization effect notable, performance
Gentle, non-stimulated medical disposable hand saver skin disinfectant solution and preparation method thereof.
The present invention is achieved through the following technical solutions:
A kind of medical disposable hand saver skin disinfectant solution, its active component is made up of the raw material of following parts by weight: hydrogen peroxide
2.1-2.7 part, tea tree oil 3-5 part, hyaluronic acid 1.5-1.8 part, mannitol 0.6-1.0 part, stearic acid 0.8-1.5 part, sweet
Oil 2.8-3.3 part, triethanolamine 2-3 part, Kazon 1.2-1.4 part, p-Hydroxybenzoate 0.8-1.2 part, medical alcohol 17-22
Part, Chinese medicine extraction liquid 25-45 part and deionized water 45-55 part；Described Chinese medicine extraction liquid is made up of the raw material of following parts by weight:
Sargassum 2-4 part, Fructus Lycii 3-6 part, Stigma Croci 3.5-4.5 part, Rhizoma Polygonati Odorati 2.6-3.2 part, Flos Chrysanthemi Indici 2.2-2.8 part, Poria 1.3-
1.6 parts, Herba Houttuyniae 3.4-3.8 part, Radix Bupleuri 3-4 part, Radix Saposhnikoviae 2.3-2.9 part, Flos Hierochloes adoratae 3-5 part, Herba speranskiae tuberculatae 2.1-2.5 part, Radix Scutellariae
1.8-2.5 part, Herba Agrimoniae 1.3-1.6 part, Pericarpium Granati 3-5 part, Folium Perillae 2-3 part, Fructus Cnidii 0.8-1.2 part, Flos Genkwa 1.6-2.0
Part.
The weight proportion of its preferred each active component is: hydrogen peroxide 2.4 parts, tea tree oil 4 parts, hyaluronic acid 1.7 parts,
Mannitol 0.8 part, stearic acid 1.2 parts, glycerol 3.1 parts, triethanolamine 2.5 parts, Kazon 1.3 parts, p-Hydroxybenzoate 1.0
Part, medical alcohol 20 parts, Chinese medicine extraction liquid 35 parts and deionized water 50 parts；Described Chinese medicine extraction liquid is former by following parts by weight
Material is made: Sargassum 3 parts, Fructus Lycii 4.5 parts, Stigma Croci 4 parts, Rhizoma Polygonati Odorati 2.9 parts, Flos Chrysanthemi Indici 2.5 parts, 1.5 parts of Poria, Herba Houttuyniae
3.6 parts, Radix Bupleuri 3.5 parts, Radix Saposhnikoviae 2.6 parts, Flos Hierochloes adoratae 4 parts, Herba speranskiae tuberculatae 2.3 parts, Radix Scutellariae 2.2 parts, Herba Agrimoniae 1.5 parts, Pericarpium Granati 4
Part, Folium Perillae 2.5 parts, Fructus Cnidii 1.0 parts, Flos Genkwa 1.8 parts.
The preparation method of this medical disposable hand saver skin disinfectant solution, employing following steps:
(1) Sargassum of above-mentioned parts by weight, Stigma Croci, Rhizoma Polygonati Odorati, Flos Chrysanthemi Indici, Flos Hierochloes adoratae, Herba Agrimoniae, Pericarpium Granati and Yuan are weighed
Flower, is placed in Chinese medicine extracting tank, by the ethanol heating and refluxing extraction that volumetric concentration is 61%-65% twice, extracts 50-70 every time
Minute, merge twice extracting solution, cold preservation 28-34 hour, filter, obtain filtrate A；
(2) weighing each raw material of Chinese medicine of residue of above-mentioned parts by weight, cross 10 mesh sieves after pulverizing respectively, mix homogeneously is placed on
In marmite, boiling twice, decoct 50-60 minute every time, filter, merge twice filtrate, in merging filtrate, add its 2 times
The volumetric concentration of quality is the ethanol of 50%-60%, stirs, and stands 20-30 hour, filters, obtains liquor B；
(3) step (1) gained filtrate A and step (2) gained liquor B are merged, clockwise stirring 20-30 minute, filter,
Room temperature is placed 40-60 minute, is evaporated to the 1/2 of original volume, obtains the concentrated liquid of tradition Chinese medicine after again filtering；
(4) according to the ratio the concentrated liquid of tradition Chinese medicine to step (3) gained that activated carbon and the concentrated liquid of tradition Chinese medicine mass ratio are 1:30
Middle addition activated carbon, stirring mixing carries out desolventing technology for 10-13 minute, filters, obtain the concentrated liquid of tradition Chinese medicine after decolouring；
(5) according to the ratio that the concentrated liquid of tradition Chinese medicine mass ratio is 1:20 the taking off to step (4) gained after clarifier and decolouring
The concentrated liquid of tradition Chinese medicine after color adds clarifier, stirs, stand 22-26 hour, filter, obtain Chinese medicine extraction liquid；
(6) mannitol and stearic acid are placed in pulverizer, mechanical activation comminution 25-30 minute, take out, be placed in stirring and dissolving
In groove, it is slowly added to deionized water, stirs while adding, be heated to when 36-43 DEG C add triethanolamine, continue stirring extremely
Being completely dissolved, add Kazon and p-Hydroxybenzoate, regulation temperature is 28 DEG C, isothermal holding 5-8 hour；
(7) take step (5) gained Chinese medicine extraction liquid, join in step (6) products therefrom, mix homogeneously, it is sequentially added into
Medical alcohol, hydrogen peroxide, hyaluronic acid and glycerol, regulation pH value is 8.2-8.6, adds tea tree oil, stirs, at 60 DEG C
After heating 10 minutes, sterilizing 20-30 minute at a temperature of 138-149 DEG C, be slowly added to NaCl under stirring, regulation product viscosity is extremely
It is 6000cps at 25 DEG C, obtains described medical disposable hand saver skin disinfectant solution.
Preferably, in step (1), the volumetric concentration of heating and refluxing extraction ethanol is 63%, the consumption of ethanol be Sargassum,
8 times of Stigma Croci, Rhizoma Polygonati Odorati, Flos Chrysanthemi Indici, Flos Hierochloes adoratae, Herba Agrimoniae, Pericarpium Granati and Flos Genkwa Chinese medicine quality.
Preferably, in step (1), the refrigerated storage temperature of extracting solution is 6-10 DEG C.
Preferably, in step (1), the refrigerated storage temperature of extracting solution is 8 DEG C.
Preferably, in step (6), the addition temperature of triethanolamine is 39 DEG C.
Preferably, the pH value of step (7) regulation product is 8.4.
Preferably, step (7) product sterilization temperature is 145 DEG C, and sterilizing time is 25 minutes.
Usage and dosage: take the medical disposable hand saver skin disinfectant solution 1-3 milliliter of the present invention, smear to each position of both hands, and
Conscientiously rub until hand is dried.
The pharmaceutical characteristic of each active component of the present invention is as follows:
Hydrogen peroxide: pure hydrogen peroxide is nattier blue thick liquid, its aqueous solution is commonly called as hydrogen peroxide, for water white transparency liquid
Body, aqueous hydrogen peroxide solution is many as antibacterial, disinfectant etc., can kill pathogenic entero becteria, pyococcus, pathogenic yeast
Bacterium.When hydrogen peroxide and skin, oral cavity and the wound of mucosa, pus or dirt meet, decompose immediately and generate oxygen, this do not tie
The oxygen atom of synthesis oxygen molecule, has the strongest oxidability, can destroy microorganism, kill antibacterial when contacting with antibacterial, and
And after killing antibacterial, remaining material is without any murder by poisoning, without the water of any stimulation, will not form secondary pollution.
Tea tree oil: tea tree oil is colourless to weak yellow liquid, pollution-free, non-corrosiveness, permeability are strong, are a kind of natural
Disinfectant, is commonly applied to personal care articles (body care, foot lotion, soap, antimicrobial form handwashing liquid, breath freshening net agent and mouth
Chamber nursing materials), can play that antiinflammatory is antibacterial, anthelmintic mite killing, antipruritic effect.
Hyaluronic acid: hyaluronic acid is a kind of acid mucopolysaccharide, and basic structure is by two dissacharide units D-Glucose aldehyde
Acid and the large-scale polysaccharide of N-acetyl-glucosamine composition, its hyalomitome molecule can carry the moisture of more than 500 times, can improve
Skin-nourishing metabolism, makes that skin is tender, smooth, wrinkle removing, increase is elastic, prevent aging, is again good saturating while moisturizing
Skin absorption enhancer.
Mannitol: mannitol is a kind of polyhydric alcohol or sugar alcohol, for colourless to white needles or rhombic prism shape crystal or
Crystalline powder, is widely present in the organisms such as plant, algae, edible fungi and lichens.
Stearic acid: stearic acid is the wax-like small pieces crystalline solid of white slightly gloss, is widely used in inhibition and generation cosmetic, surface activity
Agent, softening agent, pharmaceuticals etc..
Glycerol: glycerol is without the sweet clear and bright thick liquid of color and taste, the glycerol used in the present invention is to use acrylonitrile-chlorinated method to close
Become, including four steps: propylene high-temperature chlorination, chloropropene hypochlorination, dichlorohydrin saponification and the water of epoxychloropropane
Solve.Epoxychloropropane hydrolyze glycerol processed be 150 DEG C, under 1.37MPa pressure carbon dioxide, at 10% sodium hydroxide and 1% carbon
The aqueous solution of acid sodium is carried out, generates the glycerine water solution of sodium chloride-containing that glycerol content is 5-20%, concentrated, desalination, steaming
Evaporate, obtain the glycerol that purity is more than 98%.
Triethanolamine: triethanolamine is colourless to pale yellow transparent thick liquid, soluble in water, in alkalescence.At cosmetics
Field is usually used in surfactant.The preparation method of the triethanolamine used in the present invention: oxirane, ammonia are sent into anti-
Answer in device, under reaction temperature 30-40 DEG C, reaction pressure 70.9-304kPa, carry out condensation reaction generate one, two, triethanolamine
Mixed liquor, at 90-120 DEG C after dehydration concentrates, sends into three vacuum rectification tower and carries out decompression distillation, intercept by different boiling
Fraction.Refined: to remove ethanolamine with vapor distillation, add sodium hydroxide and make triethanolamine become alkali metal salt to separate out, separate
Rear neutralization, then carry out decompression and distill to obtain sterling.
Kazon: Kazon is light amber transparency liquid, can be with anion, cation, nonionic and the breast of various ion-type
Agent, protein compatibility, be mainly used in cosmetics anticorrosion, owing to toxicity is low, antibacterial action scope is wide, effect is strong and cosmetics are former
Material compatibility is good, and can be dissolved in water, easy to use, can be directly added into, and and p-Hydroxybenzoate in the present invention
Improve with the use of antiseptic effect.
P-Hydroxybenzoate: p-Hydroxybenzoate is white crystalline powder or colourless crystallization, is mainly used as organic conjunction
One-tenth, food, cosmetics, the sterilization antiseptic of medicine.Owing to p-Hydroxybenzoate has phenolic hydroxyl structure, so bacteria resistance
Can than benzoic acid, sorbic acid more by force, its mechanism of action is the cell membrane destroying microorganism, makes intracellular protein denaturation, and can
The respiratory enzyme system of suppression microbial cell and the activity of electron transmission enzyme system.
Medical alcohol: the composition of medical alcohol is mainly ethanol, is to ferment through distillation system through saccharifying with starch plants again
Become.The ethanol using volumetric concentration to be 75% in the present invention, is used for can be used for skin degerming, and volumetric concentration is 75%
Ethanol is close with the osmotic pressure of antibacterial, the most constantly can penetrate into inside thalline, make before bacterial surface protein is undenatured
The dehydration of antibacterial all albumen, degeneration solidification, finally kill antibacterial.
Deionized water: deionized water refers to the pure water after eliminating in ionic species impurity, for colourless clear liquid, nothing
Smelly tasteless.The deionized water used in the present invention is to use reverse osmosis equipment to carry out collocation with electrodeionization (EDI) equipment to produce
Mode, its typical process flow is: former water → more medium filter → active carbon filter → accurate filter → reverse osmosis
Equipment → electrodeionization → ultrapure water tank → ultrapure water pump → rearmounted cartridge filter → use water spot.
Sargassum: bitter in the mouth, salty, cold in nature.Return lung, spleen, kidney, liver stomach warp.Sargassum is Sargassaceae plant Sargassum fusiforme (Harv.) Setch and Sargassum
Frond, there is effect of softening the hard mass, expectorant, diuretic, detumescent, for scrofula, goiter, accumulation, edema, tinea pedis, painful and swollen testis.
Fructus Lycii: sweet in the mouth, property is put down.Return liver, kidney, lung meridian.Fructus Lycii is the fruit of plant of Solanaceae lycium barbarum, has foster
Liver, nourishing kidney, effect of lung moistening, for caused by liver and kidney deficiency, have a dizzy spell, the expensive essence of soreness of the waist and knees, sexual impotence, cough due to consumptive disease, taking fluids profusely of quenching one's thirst.
Stigma Croci: sweet in the mouth, property is put down.GUIXIN, Liver Channel.Stigma Croci is top and the stigma of irides Stigma Croci style,
Having effect of blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens, the pent-up that is used for being worried, haematemesis, typhoid fever are gone mad, women's amenorrhea, tumbling and swelling.
Rhizoma Polygonati Odorati: sweet in the mouth, property is put down.Attach to the lung and stomach meridians.Rhizoma Polygonati Odorati is the rhizome of liliaceous plant Rhizoma Polygonati Odorati, has nourishing YIN and moistening the lung, nourishing the stomach
The effect promoted the production of body fluid, for cough caused by dryness, calentura the moon liquid consumes the dry throat and mouth of wound, interior-heat is quenched one's thirst, deficiency of YIN diseases caused by exogenous pathogenic factor, dizzy dizziness.
Flos Chrysanthemi Indici: bitter in the mouth, pungent, property is put down.Return lung, Liver Channel.Flos Chrysanthemi Indici is the flower of feverfew Herba Dendranthematis indici, have heat-clearing and toxic substances removing,
Effect of dispelling wind suppressing the hyperactive liver, for furuncle, carbuncle, erysipelas, eczema, dermatitis, anemopyretic cold, laryngopharynx swelling and pain, hypertension.
Poria: sweet in the mouth, light, property is put down.GUIXIN, spleen, lung, kidney channel.Poria is the sclerotium of On Polyporaceae Poria, has and oozes
Wet diuretic, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming, for dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, insufficiency of the spleen lack of appetite,
Have loose bowels, palpitation and restlessness, insomnia forgetfulness, seminal emission nebulousurine.
Herba Houttuyniae: acrid in the mouth, cold in nature.Return liver, lung meridian.Herba Houttuyniae is the whole herb with root of saururaceae plant houttuynia cordata, has clear
Thermal detoxification, removing pus and relieving carbuncle, effect of inducing diuresis for treating stranguria syndrome, cough for lung abscess vomiting pus, expectorant dyspnea of heat type, hematodiarrhoea, carbuncle sore tumefacting virus, pyretic stranguria.
Radix Bupleuri: bitter in the mouth, pungent, cold nature.Return liver, gallbladder meridian.Radix Bupleuri is the root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii., has
Induce sweat bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, liter lift yang-energy effect, for fever caused by exogenous pathogens, alternate attack of chill and fever, malaria, stagnation of liver-QI mammary swelling；Headache mesh
Dizzy, menoxenia, the proctoptosis of collapse of QI, uterine prolapse, gastroptosis.
Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature.Return bladder, lung, spleen, Liver Channel.Radix Saposhnikoviae is the root of umbelliferae Saposhnikovia divaricata, has and dispels
Wind, relieving exterior syndrome, removing dampness to relieve pain, antipruritic effect, for affection of exogenous wind-cold, headache general pain, rheumatic arthralgia, joint is ached, stomachache is had loose bowels,
Discharging fresh blood stool, tetanus, rubella pruritus, skin infection from the beginning of.
Flos Hierochloes adoratae: sweet in the mouth, cold in nature.Flos Hierochloes adoratae is the root stock of grass family Hierochloe plant Flos Hierochloes adoratae, has removing heat from blood, hemostasis, heat clearing away
Effect of diuresis, be used for spitting blood, hematuria, acute and chronic nephritis edema, pyretic stranguria, premature ejaculation, sexual impotence, menoxenia.
Herba speranskiae tuberculatae: acrid in the mouth, warm in nature.Return lung, Liver Channel.Herba speranskiae tuberculatae is the herb of euphorbia plant speranskia tuberculata, and having dispels the wind removes
Wet, relaxing muscles and tendons to promote blood circulation, effect of removing toxic substances ophthalmalgia, for muscles and bones contracture, the disturbance of lower legs due to pathogenic cold and dampness, lumbar strain, amenorrhea, eczema scrotum, furuncle
Toxic swelling.
Radix Scutellariae: bitter in the mouth, cold in nature.Return lung, the heart, liver, gallbladder, large intestine channel.Radix Scutellariae is the root of labiate Radix Scutellariae, has heat clearing away
Pathogenic fire purging, dampness removing toxic substances, hemostasis, antiabortive effect, for cough due to lung-heat, calentura unconsciousness due to high fever, liver-fire headache, jaundice due to damp-heat, rush down
Dysentery, pyretic stranguria, haematemesis, metrorrhagia, excessive fetal movement due to heat in pregnancy, carbuncle furuncle.
Herba Agrimoniae: bitter in the mouth, puckery, property is put down.Return lung, liver, spleen channel.Herba Agrimoniae is the aerial parts of rosaceous plant Agrimony,
There is effect of astringing to arrest bleeding, parasite killing, be used for spitting blood, spit blood, hematuria, have blood in stool, dysentery, bleeding not during menses, impairment caused by overstrain take off power, carbuncle
Swollen, traumatic injury, wound hemorrhage.
Pericarpium Granati: sour in the mouth, puckery, warm in nature.Return large intestine channel.Pericarpium Granati is the peel of Punicaceae plant Punica granatum L., only has astringing intestine to stop diarrhea
Rush down, stop blooding, anthelmintic, dysentery, discharging fresh blood stool, metrorrhagia, leukorrhagia, effect of parasite killing, for epistaxis, otitis media, wound hemorrhage, menstruation
Uncomfortable, red collapse leucorrhea, have a toothache, spit blood, chronic diarrhea chronic dysentery, have blood in stool, proctoptosis, spermatorrhea, metrorrhagia, leukorrhagia, abdominal pain due to worm stagnation, scabies.
Folium Perillae: acrid in the mouth, warm in nature.Return lung, spleen, stomach warp.Folium Perillae is labiate Folium Perillae and the leaf of wild Folium Perillae or band
The little switch of leaf, have expelling cold and relieving exterior syndrome, dispersing lung-QI and dissipating phlegm, circulation of qi promoting and in, effect of antiabortive, cowfish Eriocheir sinensis poison, for exterior syndrome due to wind-cold, cough
Abundant expectoration, crisp distension, nausea and vomiting, stomachache are vomited and diarrhoea, nausea discord, gestation dislike cloudy, ichthyophagy Eriocheir sinensis poisoning.
Fructus Cnidii: acrid in the mouth, hardship, warm in nature.Return spleen, kidney channel.Fructus Cnidii is the fruit of samphire cnidium monnieri, has the kidney warming and strengthens
Sun, removing dampness and killing parasites, effect of dispelling wind for relieving itching, swell and ache for impotence in male, scrotum pruritus due to damp pathogen, cold-damp leukorrhagia, pudendal pruritus, eczema scabies.
Flos Genkwa: acrid in the mouth, hardship, warm in nature.Return lung, spleen, kidney, bladder warp.Flos Genkwa is the alabastrum of Isolated From Thymelaeaceae Species Flos Genkwa, has and rushes down
Water by drink, expelling phlegm for arresting cough, effect of removing toxic substances parasite killing, for edema, expansion, phlegm retention hydrothorax, breath with cough, carbuncle furuncle tinea.
The invention has the beneficial effects as follows:
1, the medical disposable hand saver skin disinfectant solution of the present invention can effectively kill various etc., has broad spectrum activity, and bactericidal effect is notable,
Can effectively kill the various bacterium between palm and webs, such as Aeromonas, staphylococcus, corynebacterium, klebsiella, molten
Blood acinetobacter calcoaceticus, lung inflammatory streptococcus, escherichia coli, saccharomytes, can be prevented effectively from patient or health care worker
Ill probability, and use and easy to carry, both hands can be cleaned whenever and wherever possible, the Disinfection Effect persistent period is long, sustainable
4-6 hour, effectively reduce the cross infection of public place.
2, the medical disposable hand saver skin disinfectant solution of the present invention can remove antibacterial and the virus of hand comprehensively, plurality of raw materials is mixed
Collocation, scientific composition, each raw material is had complementary advantages, and utilizes the collaborative or resistant function that it is mutual, adds moisturizing skin protection and become
Point, such as tea tree oil, stearic acid, glycerol, decrease the stimulation to skin, nourishes rough skin, keep hand to moisten, pH value is close to skin
The pH of skin, product property is gentle, nontoxic non-stimulated to normal skin, safe and efficient.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but the invention is not limited in this, the system in embodiment
Preparation Method is customary preparation methods, no longer describes in detail.
Embodiment 1:
This medical disposable hand saver skin disinfectant solution, its active component is made up of the raw material of following weight: hydrogen peroxide 2.1 thousand
Gram, tea tree oil 3 kilograms, hyaluronic acid 1.5 kilograms, mannitol 0.6 kilogram, stearic acid 0.8 kilogram, glycerol 2.8 kilograms, three second
Hydramine 2 kilograms, Kazon 1.2 kilograms, p-Hydroxybenzoate 0.8 kilogram, medical alcohol 17 kilograms, Chinese medicine extraction liquid 25 kilograms and
Deionized water 45 kilograms；Described Chinese medicine extraction liquid is made up of the raw material of following weight: Sargassum 2 kilograms, Fructus Lycii 3 kilograms, safranine
Spend 3.5 kilograms, Rhizoma Polygonati Odorati 2.6 kilograms, Flos Chrysanthemi Indici 2.2 kilograms, 1.3 kilograms of Poria, Herba Houttuyniae 3.4 kilograms, Radix Bupleuri 3 kilograms, Radix Saposhnikoviae
2.3 kilograms, Flos Hierochloes adoratae 3 kilograms, Herba speranskiae tuberculatae 2.1 kilograms, Radix Scutellariae 1.8 kilograms, Herba Agrimoniae 1.3 kilograms, Pericarpium Granati 3 kilograms, Folium Perillae 2
Kilogram, Fructus Cnidii 0.8 kilogram, Flos Genkwa 1.6 kilograms.
Preparation method: (1) weighs the Sargassum of above-mentioned weight, Stigma Croci, Rhizoma Polygonati Odorati, Flos Chrysanthemi Indici, Flos Hierochloes adoratae, Herba Agrimoniae, Pericarpium Granati
And Flos Genkwa, it being placed in Chinese medicine extracting tank, the alcohol heating reflux with 63% extracts twice, extracts 60 minutes, united extraction every time
Liquid, filters, and cold preservation 32 hours, filtrate is standby；The consumption of ethanol is 8 times of Chinese medicine quality；Refrigerated condition is 8 DEG C；
(2) weigh each raw material of Chinese medicine of residue of above-mentioned weight, cross 10 mesh sieves, mix homogeneously after pulverizing respectively, be placed in marmite
In, boiling twice, decoct 55 minutes every time, filter, merging filtrate, add the ethanol of 2 times amount 55%, stir, stand
25 hours, filter, obtain medicinal liquid；
(3) step (1) gained filtrate and step (2) gained medicinal liquid are merged, clockwise stirring 25 minutes, filter, room temperature
Place 50 minutes, again filter, be concentrated into the 1/2 of original volume, obtain the concentrated liquid of tradition Chinese medicine；
(4) according to the ratio the concentrated liquid of tradition Chinese medicine to step (3) gained that activated carbon and the concentrated liquid of tradition Chinese medicine mass ratio are 1:30
Middle addition activated carbon, stirring mixing carries out desolventing technology for 12 minutes, filters, obtain the concentrated liquid of tradition Chinese medicine after decolouring；
(5) according to the ratio that the concentrated liquid of tradition Chinese medicine mass ratio is 1:20 the taking off to step (4) gained after clarifier and decolouring
The concentrated liquid of tradition Chinese medicine after color adds clarifier, stirs, stand 24 hours, filter, obtain Chinese medicine extraction liquid；
(6) mannitol and stearic acid are placed in pulverizer, mechanical activation comminution 28 minutes, take out, be placed in stirring and dissolving groove
In, it is slowly added to deionized water, stirs while adding, be heated to when 39 DEG C add triethanolamine, continue stirring to completely
Dissolving, add Kazon and p-Hydroxybenzoate, regulation temperature is 28 DEG C, isothermal holding 7 hours；
(7) take step (5) gained Chinese medicine extraction liquid, join in step (6) products therefrom, mix homogeneously, it is sequentially added into
Medical alcohol, hydrogen peroxide, hyaluronic acid and glycerol, regulation Ph value is 8.4, adds tea tree oil, stirs, and heats at 60 DEG C
After 10 minutes, sterilizing 25 minutes, be slowly added to NaCl under stirring at a temperature of 145 DEG C, regulation product viscosity is at 25 DEG C being
6000cps, obtains this medical disposable hand saver skin disinfectant solution.
Usage and dosage: take the medical disposable hand saver skin disinfectant solution 1-3 milliliter of the present invention, smear to each position of both hands, and
Conscientiously rub until hand is dried.
Embodiment 2:
This medical disposable hand saver skin disinfectant solution, its active component is made up of the raw material of following weight: hydrogen peroxide 2.7 thousand
Gram, tea tree oil 5 kilograms, hyaluronic acid 1.8 kilograms, mannitol 1.0 kilograms, stearic acid 1.5 kilograms, glycerol 3.3 kilograms, three second
Hydramine 2-3 kilogram, Kazon 1.4 kilograms, p-Hydroxybenzoate 1.2 kilograms, medical alcohol 22 kilograms, Chinese medicine extraction liquid 45 kilograms
With deionized water 55 kilograms；Described Chinese medicine extraction liquid is made up of following raw material: Sargassum 4 kilograms, Fructus Lycii 6 kilograms, Stigma Croci
4.5 kilograms, Rhizoma Polygonati Odorati 3.2 kilograms, Flos Chrysanthemi Indici 2.8 kilograms, 1.6 kilograms of Poria, Herba Houttuyniae 3.8 kilograms, Radix Bupleuri 4 kilograms, Radix Saposhnikoviae 2.9
Kilogram, Flos Hierochloes adoratae 5 kilograms, Herba speranskiae tuberculatae 2.5 kilograms, Radix Scutellariae 2.5 kilograms, Herba Agrimoniae 1.6 kilograms, Pericarpium Granati 5 kilograms, Folium Perillae 3,000
Gram, Fructus Cnidii 1.2 kilograms, Flos Genkwa 2.0 kilograms.
Preparation method and usage and dosage are with embodiment 1.
Embodiment 3:
This medical disposable hand saver skin disinfectant solution, its active component is made up of the raw material of following weight: hydrogen peroxide 2.4 thousand
Gram, tea tree oil 4 kilograms, hyaluronic acid 1.7 kilograms, mannitol 0.8 kilogram, stearic acid 1.2 kilograms, glycerol 3.1 kilograms, three second
Hydramine 2.5 kilograms, Kazon 1.3 kilograms, p-Hydroxybenzoate 1.0 kilograms, medical alcohol 20 kilograms, Chinese medicine extraction liquid 35 kilograms
With deionized water 50 kilograms；Described Chinese medicine extraction liquid is made up of the raw material of following weight: Sargassum 3 kilograms, Fructus Lycii 4.5 kilograms,
Stigma Croci 4 kilograms, Rhizoma Polygonati Odorati 2.9 kilograms, Flos Chrysanthemi Indici 2.5 kilograms, 1.5 kilograms of Poria, Herba Houttuyniae 3.6 kilograms, Radix Bupleuri 3.5 kilograms,
Radix Saposhnikoviae 2.6 kilograms, Flos Hierochloes adoratae 4 kilograms, Herba speranskiae tuberculatae 2.3 kilograms, Radix Scutellariae 2.2 kilograms, Herba Agrimoniae 1.5 kilograms, Pericarpium Granati 4 kilograms, purple
Folium Perillae 2.5 kilograms, Fructus Cnidii 1.0 kilograms, Flos Genkwa 1.8 kilograms.
Preparation method and usage and dosage are with embodiment 1.
Test example: use the medical disposable hand saver skin disinfectant solution of the present invention, does bacteriostasis property experiment, skin irritation in fact respectively
Test and sterilize efficacy experiment.
One, bacteriostasis property experiment: take medical disposable hand saver skin disinfectant solution (embodiment 1-3) of gained of the present invention, study it right
The fungistatic effect of multiple bacterium.
1.1 select strain
Aeromonas, staphylococcus, corynebacterium, klebsiella, acinetobacter haemolyticus, lung inflammatory streptococcus, large intestine
Bacillus, saccharomytes (being provided by the hospital of traditional Chinese hospital of Jinan City).
1.2 experimental technique
With Aeromonas, staphylococcus, corynebacterium, klebsiella, acinetobacter haemolyticus, lung inflammatory streptococcus, big
Enterobacteria, saccharomytes are experimental strain, carry out activation culture respectively, after growing single bacterium colony, use inoculating loop picking respectively
Thalline is in the test tube filling physiological saline solution a little, and shaken well is prepared as suspension.Aseptically, at 90mm
Culture dish in add appropriate culture medium, add 100 microlitre bacterium solution after solidification, coating uniformly, stands 20-30 minute.
Medical for gained of the present invention disposable hand saver skin disinfectant solution and other disposable hand saver skin disinfectant solution are made a diameter of respectively
The circle of 0.4cm, is placed on solid medium, and same culture dish is sequentially placed other disposable hand saver skin disinfectant solution and Ben Fa
The medical disposable hand saver skin disinfectant solution of bright gained, is repeated 10 times, and antibacterial cultivates 24h in the constant incubator of 37 DEG C.Observe various kinds
Product and culture medium contact surface are with or without bacterial growth, and measure antibacterial circle diameter size.Use SPSS v11.5 software data processing,
Data represent with mean ± standard deviation (x ± S), and concrete condition is shown in Table 1:
Table 1: each sample contact antibacterial antibacterial circle diameter (unit: the cm to strain；Sample diameter 0.4cm)
As can be seen from Table 1, the medical disposable hand saver skin disinfectant solution of the present invention and other disposable hand saver skin disinfectant solution are respectively provided with
Preferably contact the contact surface of bacteriostasis, sample and culture medium all without bacterial growth.But the medical disposable hand saver skin of the present invention disappears
The fungistatic effect of venom is higher, and such as to staphylococcic experiment, the medical disposable hand saver skin disinfectant solution of this product is to staphylococcus
Contacting antibacterial antibacterial circle diameter is 0.785 ± 0.0237cm, and staphylococcus contact is pressed down by other disposable hand saver skin disinfectant solution
The antibacterial circle diameter of bacterium is 0.523 ± 0.0158cm, it is clear that the fungistatic effect of the medical disposable hand saver skin disinfectant solution of gained of the present invention
More significantly.
Two, in order to verify whether medical disposable hand saver skin disinfectant solution (embodiment 1-3) of the present invention has a zest: 2014
In August ,-2014 in February has done skin irritation test.
Use repeatedly intact skin irritant test method, screen 100 Kunming little Bai that skin is intact, body weight is 18-22g
Mus, tests first 2 days, sloughs the hair of each about 2cm × 2cm in its spinal column both sides, back respectively, the present invention is prepared medical disposable next day
Hand saver skin disinfectant solution is coated in the left side of every white mice and takes off plucked skin surface, fixes by non-stimulated medical sterile gauze；
Taking off plucked skin surface on the right side of every white mice smears the distilled water of equivalent simultaneously, equally with non-stimulated medical aseptic
Gauze is fixed；Removing sterile gauze after 6 hours, method is smeared once every day as described above, smears continuously 5 days, and period observes
The local response of skin and the W-response of health, carry out irritant reaction scoring.
100 Kunming white mice are tried by Skin Irritation Test result: use repeatedly intact skin irritant test method
Test, to detect medical disposable hand saver skin disinfectant solution prepared by the present invention to the stimulation of laboratory animal skin and intensity.Respectively
Observing the local skin reaction of tested white mice spinal column both sides during test and after test, observed result is test white mice both sides
Skin is all without other malaise symptoms such as redness and erythema, and scoring is 0, so the skin of the medical disposable hand saver skin disinfectant solution of the present invention
Skin stimulus intensity is classified as nonirritant rank, can relieved use.
Three, sterilization efficacy experiment
In order to verify the curative effect of the medical disposable hand saver skin disinfectant solution (embodiment 3) of the present invention :-2014 years 7 in October, 2013
The moon has done contrast test.
General data: screen 150 example surgical operation and nurses, be randomly divided into experimental group and two groups of matched group, wherein
Experimental group has 100 people, and matched group has 50 people, uses double blind experiment mode to test.
Sampling time: sample respectively before and after using disposable hand saver skin disinfectant solution.
Usage and dosage: experimental group uses the medical disposable hand saver skin disinfectant solution of the present invention, takes products obtained therefrom 1-3 of the present invention milli
Rise, smear under each position, forearm and the upper arm of both hands 1/3, and conscientiously rub until disinfectant is dried；Matched group uses it
His disposable hand saver skin disinfectant solution, such as Safeguard handwashing liquid, using method is identical with experimental group.
The method of sampling: examinee's the five fingers close up, the cotton swab soaked with the aseptic eluent being soaked with containing corresponding nertralizer exists
Both hands refer to curved surface from finger tip to finger tip double rub 2 times, a hands embrocates area about 30cm2, during embrocating, rotate cotton simultaneously
Swab；The part of cotton swab operating of contacts person is cut off, puts in the 10ml aseptic eluent test tube containing corresponding nertralizer, in time
Censorship.
Detection method is: is vibrated on vortex mixer 20 seconds by sampling tube or firmly rapping 80 times, draws with aseptic straw
1.0ml measuring samples is inoculated in sterilizing plate, and 2 plates inoculated by each sample, 45 DEG C-48 DEG C that in plate, addition has been dissolved
Nutrient agar 15ml-18ml, pours into while shake up, treats agar solidification, puts 36 DEG C ± l DEG C mixed case and cultivates 48h, counts clump count.
Total number of bacterial colonies computational methods: total number of bacterial colonies (cfu/cm2Clump count × extension rate/sampling area on)=flat board
(cm2).Shown by detection bacterial clump: the average bacteriological total plate count of the use medical disposable hand saver skin disinfectant solution of the present invention is
4.368cfu/cm2, and using the average bacteriological total plate count of Safeguard handwashing liquid is 9.349cfu/cm2.This it appears that this
Invent medical disposable hand saver skin disinfectant solution and can quickly kill the pathogenic microorganisms such as the various viruses on hand, antibacterial, bactericidal effect
More significantly, can fully meet surgical personnel and the nurse needs to hand antibacterial sterilizing.
To sum up, it can be seen that bactericidal effect the killing than existing handwashing liquid of the medical disposable hand saver skin disinfectant solution of the present invention
Bacterium effect is more significantly, and properties of product are gentle, nontoxic non-stimulated to skin, and should be widely promoted application.
Claims (9)
1. a medical disposable hand saver skin disinfectant solution, is characterized in that: its active component is made up of the raw material of following parts by weight: mistake
Hydrogen oxide 2.1-2.7 part, tea tree oil 3-5 part, hyaluronic acid 1.5-1.8 part, mannitol 0.6-1.0 part, stearic acid 0.8-1.5
Part, glycerol 2.8-3.3 part, triethanolamine 2-3 part, Kazon 1.2-1.4 part, p-Hydroxybenzoate 0.8-1.2 part, medical alcohol
17-22 part, Chinese medicine extraction liquid 25-45 part and deionized water 45-55 part；Described Chinese medicine extraction liquid is by the raw material of following parts by weight
Make: Sargassum 2-4 part, Fructus Lycii 3-6 part, Stigma Croci 3.5-4.5 part, Rhizoma Polygonati Odorati 2.6-3.2 part, Flos Chrysanthemi Indici 2.2-2.8 part, Poria
1.3-1.6 part, Herba Houttuyniae 3.4-3.8 part, Radix Bupleuri 3-4 part, Radix Saposhnikoviae 2.3-2.9 part, Flos Hierochloes adoratae 3-5 part, Herba speranskiae tuberculatae 2.1-2.5 part,
Radix Scutellariae 1.8-2.5 part, Herba Agrimoniae 1.3-1.6 part, Pericarpium Granati 3-5 part, Folium Perillae 2-3 part, Fructus Cnidii 0.8-1.2 part, Flos Genkwa
1.6-2.0 part.
Medical disposable hand saver skin disinfectant solution the most according to claim 1, is characterized in that: its active component is by following weight portion
Number raw material make: hydrogen peroxide 2.4 parts, tea tree oil 4 parts, hyaluronic acid 1.7 parts, mannitol 0.8 part, stearic acid 1.2 parts,
Glycerol 3.1 parts, triethanolamine 2.5 parts, Kazon 1.3 parts, p-Hydroxybenzoate 1.0 parts, medical alcohol 20 parts, Chinese medicine extraction liquid
35 parts and deionized water 50 parts；Described Chinese medicine extraction liquid is made up of the raw material of following parts by weight: Sargassum 3 parts, Fructus Lycii 4.5
Part, Stigma Croci 4 parts, Rhizoma Polygonati Odorati 2.9 parts, Flos Chrysanthemi Indici 2.5 parts, 1.5 parts of Poria, Herba Houttuyniae 3.6 parts, Radix Bupleuri 3.5 parts, Radix Saposhnikoviae 2.6 parts,
Flos Hierochloes adoratae 4 parts, Herba speranskiae tuberculatae 2.3 parts, Radix Scutellariae 2.2 parts, Herba Agrimoniae 1.5 parts, Pericarpium Granati 4 parts, Folium Perillae 2.5 parts, Fructus Cnidii 1.0 parts,
Flos Genkwa 1.8 parts.
3., according to the preparation method of the arbitrary described medical disposable hand saver skin disinfectant solution of claim 1-2, it is characterized in that: include as
Lower step:
(1) weigh the Sargassum of above-mentioned parts by weight, Stigma Croci, Rhizoma Polygonati Odorati, Flos Chrysanthemi Indici, Flos Hierochloes adoratae, Herba Agrimoniae, Pericarpium Granati and Flos Genkwa, put
In Chinese medicine extracting tank, by the ethanol heating and refluxing extraction that volumetric concentration is 61%-65% twice, extract 50-70 minute every time,
Merge twice extracting solution, cold preservation 28-34 hour, filter, obtain filtrate A；
(2) weighing each raw material of Chinese medicine of residue of above-mentioned parts by weight, cross 10 mesh sieves after pulverizing respectively, mix homogeneously is placed on marmite
In, boiling twice, decoct 50-60 minute every time, filter, merge twice filtrate, in merging filtrate, add its 2 times of quality
The ethanol that volumetric concentration is 50%-60%, stir, stand 20-30 hour, filter, obtain liquor B；
(3) step (1) gained filtrate A and step (2) gained liquor B are merged, clockwise stirring 20-30 minute, filter, room temperature
Place 40-60 minute, be evaporated to the 1/2 of original volume after again filtering, obtain the concentrated liquid of tradition Chinese medicine；
(4) add in the concentrated liquid of tradition Chinese medicine of step (3) gained with the ratio that the concentrated liquid of tradition Chinese medicine mass ratio is 1:30 according to activated carbon
Entering activated carbon, stirring mixing carries out desolventing technology for 10-13 minute, filters, obtain the concentrated liquid of tradition Chinese medicine after decolouring；
(5) according to the ratio that the concentrated liquid of tradition Chinese medicine mass ratio is 1:20 after clarifier and decolouring after the decolouring of step (4) gained
The concentrated liquid of tradition Chinese medicine in add clarifier, stir, stand 22-26 hour, filtration, obtain Chinese medicine extraction liquid；
(6) mannitol and stearic acid are placed in pulverizer, mechanical activation comminution 25-30 minute, take out, be placed in stirring and dissolving groove
In, it is slowly added to deionized water, stirs while adding, be heated to when 36-43 DEG C add triethanolamine, continue stirring to complete
CL, adds Kazon and p-Hydroxybenzoate, and regulation temperature is 28 DEG C, isothermal holding 5-8 hour；
(7) take step (5) gained Chinese medicine extraction liquid, join in step (6) products therefrom, mix homogeneously, it is sequentially added into medical
Ethanol, hydrogen peroxide, hyaluronic acid and glycerol, regulation pH value is 8.2-8.6, adds tea tree oil, stirs, and heats at 60 DEG C
After 10 minutes, sterilizing 20-30 minute at a temperature of 138-149 DEG C, be slowly added to NaCl under stirring, regulation product viscosity is to 25 DEG C
It is 6000cps down, obtains described medical disposable hand saver skin disinfectant solution.
The preparation method of medical disposable hand saver skin disinfectant solution the most according to claim 3, is characterized in that: step adds in (1)
The volumetric concentration of circumfluence distillation ethanol is 63%, and the consumption of ethanol is Sargassum, Stigma Croci, Rhizoma Polygonati Odorati, Flos Chrysanthemi Indici, Flos Hierochloes adoratae, celestial being
Crane grass, Pericarpium Granati and 8 times of Flos Genkwa Chinese medicine quality.
The preparation method of medical disposable hand saver skin disinfectant solution the most according to claim 3, is characterized in that: step carries in (1)
The refrigerated storage temperature taking liquid is 6-10 DEG C.
The preparation method of medical disposable hand saver skin disinfectant solution the most according to claim 5, is characterized in that: step carries in (1)
The refrigerated storage temperature taking liquid is 8 DEG C.
The preparation method of medical disposable hand saver skin disinfectant solution the most according to claim 3, is characterized in that: in step (6) three
The addition temperature of ethanolamine is 39 DEG C.
The preparation method of medical disposable hand saver skin disinfectant solution the most according to claim 3, is characterized in that: step (7) regulates
The pH value of product is 8.4.
The preparation method of medical disposable hand saver skin disinfectant solution the most according to claim 3, is characterized in that: step (7) product
Sterilization temperature is 145 DEG C, and sterilizing time is 25 minutes.
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| CN111358706A (en) * | 2020-04-13 | 2020-07-03 | 杭州万事利丝绸文化股份有限公司 | Preparation method of alcohol-fibroin gel washing-free disinfectant |
| US11730692B2 (en) | 2020-09-30 | 2023-08-22 | Nanjing Letop Biotechnology Co., Ltd. | Instant hand-protection antibacterial gel, method for preparing the same and use of the same |
| CN112353711A (en) * | 2020-12-04 | 2021-02-12 | 维尼健康（深圳）股份有限公司 | Sterilizing wet tissue and manufacturing method thereof |
| CN112933161A (en) * | 2021-02-04 | 2021-06-11 | 贵州碘雅医疗器械有限公司 | Composite iodophor disinfectant |
| CN115400048A (en) * | 2022-09-28 | 2022-11-29 | 王强 | Wash-free hand skin care disinfectant and preparation method thereof |
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