CN110354034A

CN110354034A - A kind of environment-friendly type Chinese medicine compound prescription hand disinfectant and preparation method thereof

Info

Publication number: CN110354034A
Application number: CN201910666974.6A
Authority: CN
Inventors: 梁晓雅; 董雨馨; 张建安; 陈明霞; 杨志滨; 刘宏; 魏秋霞; 魏巧妙; 杨致霈
Original assignee: Affiliated Hospital of Shaanxi University of Chinese Medicine
Current assignee: Affiliated Hospital of Shaanxi University of Chinese Medicine
Priority date: 2019-07-23
Filing date: 2019-07-23
Publication date: 2019-10-22

Abstract

The present invention relates to disinfectant technical fields, a kind of environment-friendly type Chinese medicine compound prescription hand disinfectant is specifically disclosed, is made of the following components according to parts by weight: 15~25 parts of surfactant, 50~60 parts of Chinese medicine extract, 0.5~1.5 part of glycerol, 0.2~0.5 part of sodium benzoate, 0.5~1.0 part of essence, 1.5~2.0 parts of sodium chloride, 20~25 parts of deionized water.The present invention also provides a kind of preparation methods of environment-friendly type Chinese medicine compound prescription hand disinfectant.Environment-friendly type Chinese medicine compound prescription hand disinfectant provided by the invention is safe and non-stimulating, and has good restraining and sterilizing bacteria effect.

Description

A kind of environment-friendly type Chinese medicine compound prescription hand disinfectant and preparation method thereof

Technical field

The present invention relates to disinfectant technical fields, specifically disclose a kind of environment-friendly type Chinese medicine compound prescription hand disinfectant and its preparation side Method.

Background technique

In the fields such as pharmaceutical sanitary field or food safety, staff is carrying out certain work, needs first opponent or hand The positions such as arm carry out disinfection, and most of hand disinfectant that tradition uses contains chlorine, alcohols, aldehydes, peroxide, organic phenolate The ingredients such as object are closed, have different degrees of adverse effect to human skin mucous membrane, and use dangerous, biological degradability Difference, water environment easy to pollute, and it is easy to produce bacterial drug resistance；And the chemical component that uses of part disinfectant or organic solvent for The specific crowd of some easy allergy is not available.Therefore, develop it is a kind of it is safe and non-toxic, biological degradability is good, low drug resistance and energy The disinfectant for enough effectively antagonizing allergy has great importance.

Summary of the invention

The present invention provides a kind of environment-friendly type Chinese medicine compound prescription hand disinfectant for the problems in background technique.

Environment-friendly type Chinese medicine compound prescription hand disinfectant provided by the invention, is made of the following components: surface according to parts by weight 15~25 parts of activating agent, 50~60 parts of Chinese medicine extract, 0.5~1.5 part of glycerol, 0.2~0.5 part of sodium benzoate, essence 0.5 ~1.0 parts, 1.5~2.0 parts of sodium chloride, 20~25 parts of deionized water；

Wherein, the Chinese medicine extract is made of the following components according to parts by weight: 15~25 parts of folium artemisiae argyi, dandelion 15~ 25 parts, 10~20 parts of Filifolium sibiricum, 15~25 parts of radix scutellariae, windproof 10~20 parts, 8~15 parts of dark plum, 8~15 parts of campanulaceae, cordate houttuynia 10~20 parts, 5~8 parts of Schisandra chinensis, 5~8 parts of hawthorn, 3~5 parts of borneol.

Preferably, it is made of the following components according to parts by weight: 22 parts of surfactant, 54 parts of Chinese medicine extract, sweet Oily 1.5 parts, 0.5 part of sodium benzoate, 0.8 part of essence, 1.8 parts of sodium chloride, 22 parts of deionized water；

Wherein, the Chinese medicine extract is made of the following components according to parts by weight: 22 parts of folium artemisiae argyi, 25 parts of dandelion, line 15 parts of leaf chrysanthemum, 20 parts of radix scutellariae, windproof 18 parts, 12 parts of dark plum, 15 parts of campanulaceae, 15 parts of cordate houttuynia, 6 parts of Schisandra chinensis, 8 parts of hawthorn, ice 5 parts of piece.

Preferably, the green surfactant is AEO carboxylic acid sodium, polyglyceryl fatty acid ester, alkyl One or more of poly glucoside, modified grease and vegetable oil acid.

It is highly preferred that the vegetable oil acid is one or more of behenic acid, cotton oil acid and rape oil acid.

Preferably, the essence is soluble perfume.

The present invention also provides a kind of preparation methods of environment-friendly type Chinese medicine compound prescription hand disinfectant, specifically include following step It is rapid:

Step 1 weighs 15~25 parts of folium artemisiae argyi, 15~25 parts of dandelion, 10~20 parts of Filifolium sibiricum, radix scutellariae 15 in parts by weight ~25 parts, windproof 10~20 parts, 8~15 parts of dark plum, 8~15 parts of campanulaceae, 10~20 parts of cordate houttuynia, 5~8 parts of Schisandra chinensis, hawthorn 5 ~8 parts, 3~5 parts of borneol；

Step 2, by folium artemisiae argyi weighed in step 1, dandelion, Filifolium sibiricum, radix scutellariae, radix saposhnikoviae, dark plum, campanulaceae, cordate houttuynia, five Taste, hawthorn are uniformly mixed, and the deionized water for being equivalent to 12~20 times of its total weight amounts, 60 DEG C~85 DEG C reflux are added for the first time 1.0~3.0h is extracted, first time filtrate is collected in filtering；The deionized water for being equivalent to 6~10 times of its total weight amounts is added in filter residue, Second of filtrate is collected in 60 DEG C~85 DEG C 1.0~3.0h of refluxing extraction, filtering；Merge filtrate twice, is condensed under room temperature opposite The solution that density is 1.05~1.15, it is spare；

Step 3 will carry out absorb-elute in the addition macroporous resin adsorption column of concentrate obtained in step 2, and eluant, eluent is The ethanol solution that mass fraction is 5~10%, elution flow rate 1mL/min collect eluent, spare；

Eluent obtained in step 3 is concentrated into 1mg/mL by step 4, then by borneol and grinding poling weighed in step 1 Fine powder is added in the eluent after being concentrated, stirs evenly, obtain Chinese medicine extract；

Step 5, weigh in parts by weight 15~25 parts of surfactant, 50~60 parts of Chinese medicine extract, glycerol 0.5~ 1.5 parts, 0.2~0.5 part of sodium benzoate, 0.5~1.0 part of essence, 1.5~2.0 parts of sodium chloride, 20~25 parts of deionized water, it is standby With；

Step 6, surfactant weighed in step 5 is heated to 70 DEG C melting, be down to after 40 DEG C again with glycerol, benzene first Sour sodium, essence, sodium chloride and deionized water are uniformly mixed, and Chinese medicine extract obtained in step 4 is added, stir evenly to get Chinese medicine compound prescription hand disinfectant.

In the present invention each Chinese medicine material medicine effect and pharmacological action it is as follows:

1, folium artemisiae argyi: pungent, bitter, temperature.Warming channel for arresting bleeding, eliminating cold to stop pain；External application removing dampness to stop itchin.For spitting blood, bleeding from five sense organs or subcutaneous tissue, metrorrhagia and metrostaxis, the moon Through through more.Blood under vaginal bleeding during pregnancy, abdomen crymodynia are uncomfortable through trembling with fear, uterus cold infertile；Pruitus is controlled outside.Modern pharmacological research proves, folium artemisiae argyi With anti-allergic effects, Blumea oil 50mL/kg is gavaged to the cavy of egg protein sensitization, can inhibit is caused with egg protein attack again Anaphylactic shock generation, folium artemisiae argyi antiallergy mechanism may be inhibit Anaphylactic mediator release or facedown Anaphylactic mediator； Folium artemisiae argyi also has antibacterial, antivirus action, and folium artemisiae argyi decocting liquid, folium artemisiae argyi sootiness and volatile argyi leaf oil kill various bacteria, virus Go out or inhibiting effect, experiment in vitro show Blumea oil to coccus (white and staphylococcus aureus, A type and beta streptococcus, Diplococcus pneumopniae and Neisseria) and most of gram negative bacillis (influenza, deformation, typhoid fever, paratyphoid, large intestine, secondary large intestine and dysentery Shigella) there is inhibiting effect；Moxa stick fumigating has killing or inhibiting effect to more than 10 kinds of common bacterias, such as staphylococcus, diphtheria Bacillus, Pseudomonas aeruginosa, tubercle bacillus, Escherichia coli etc.；Also there are different degrees of inhibiting effect, such as gypsum to a variety of dermatophytes Sample trichophyta, achorion etc.；Experiment in vitro the study found that 45% alcohol extract of folium artemisiae argyi under the concentration of 12.5mg/mL, to short broom Mould, aspergillus niger, altogether mould, Alternaria, bud branch be mould, stemphylium, botrytis sp, aspergillus versicolor, Aspergillus terreus, aspergillus ustus, gauffer Mould, penicillium purpurogenum, penicillium oxalicum, penicillium funiculosum, penicillium cyclopium, sickle-like bacteria have antibacterial activity；Folium artemisiae argyi sootiness is to adenovirus, nose Virus, influenza virus and parainfluenza virus have certain inhibiting effect.

2, dandelion: it is bitter, sweet, it trembles with fear.Clearing heat and detoxicating, dispersing swelling and dissipating binds, inducing diuresis for treating strangurtia.For furuncle swelling toxin, acute mastitis, scrofula, Hot eyes, pharyngalgia, pulmonary abscess.Modern pharmacological research proves, dandelion has an antibacterial action, experiment in vitro show the fresh juice of dandelion, 100% water decoction and extract saponin(e are to staphylococcus aureus, staphylococcus albus, hemolytic streptococcus, Escherichia coli, pair B-mode bacillus of Escherichia coli, catalin diplococcus, typhoid bacillus, paratyphoid etc. has stronger inhibiting effect；To Diplococcus pneumopniae, brain Film inflammation diplococcus, corynebacterium diphtheriae, proteus, shigella dysenteriae etc. have certain inhibiting effect；1:400 can in vitro inhibit Tubercle bacillus has inhibiting effect to the pathogenic dermatophyte such as microsporon audouini, Trichophyton schoenleini；Dandelion flooding agent (1: 4) in vitro to trichophyton, Trichophyton concentricum, Trichophyton schoenleini, the small gemma tinea bacterium of Du Ang Shi difficult to understand, rust budlet The small gemma tinea bacterium of spore tinea bacterium, ulotrichy, gypsum sample little gemma tinea bacterium, epidermophyton inguinale, star-shaped nocardia etc. have inhibition Effect.

3, cordate houttuynia: it is pungent, it is slightly cold.Clearing heat and detoxicating disappears carbuncle apocenosis, inducing diuresis for treating strangurtia.For lung carbuncle pyemesis, phlegm heat panting cough, heat Dysentery, heat gonorrhea, carbuncle sore tumefacting virus.Modern pharmacological research proves that cordate houttuynia has antibacterial action, and cordate houttuynia decoction is to Staphylococcus aureus Bacterium, staphylococcus albus, hemolytic streptococcus, Diplococcus pneumopniae, corynebacterium diphtheriae, proteus, bacillus dysenteriae, Amur bacillus, A variety of Grain-positives such as Fu Shi bacillus and bacterium sonnei, bacillus enteritidis, hog cholera bacillus and negative bacteria, Leptospira Deng there is inhibiting effect；Experiment shows that cordate houttuynia has the function of inhibiting and kills helicobacter pylori (Hp), meanwhile, fish raw meat The effect of saprophytic removing possessed by grass, enables its ulcer spot to accelerate to heal, and promotes stomach lining reparation；Antivirus action, fish raw meat Grass has inhibiting effect to a variety of viruses, the study found that houttuynia extract is to Asia Alphavirus, influenza virus, Hemorrhagic fever Virus has apparent inhibiting effect, with the primary adhesion tissue cultures of human embryo kidney (HEK), observes cordate houttuynia (1:10) convection current There is inhibiting effect in section 68-1 plants of A type capital of sense, and can delay the cytopathic effect of orphan virus.Cordate houttuynia fixed oil mentions Object (1:4) intraperitoneal injection infected by influenza FM. experimental infection mouse is taken to have obvious prevention effect；Cordate houttuynia distillate to HSV-1, Influenza virus and HIV have direct inhibitory activity.

4, radix scutellariae: it is bitter, it trembles with fear.Heat-clearing and damp-drying drug, purging fire for removing toxin, hemostasis, miscarriage prevention.For damp-warm syndrome, heat temperature, chest tightness and emesis is damp and hot Feeling of fullness, dysentery.Modern pharmacological research proves, radix scutellariae has resisting pathogenic microbes effect, and research has shown that, radix scutellariae to Grain-positive with Negative bacterium such as staphylococcus aureus, hemolytic streptococcus, Diplococcus pneumopniae, diplococcus meningitidis, shigella dysenteriae, typhoid fever bar Bacterium, paratyphosum Bacterium, Escherichia coli, Pseudomonas aeruginosa, comma bacillus, corynebacterium diphtheriae, Bordetella pertussis, Candida albicans, fragility Bacteroid (non-pressure three-product cyclone) etc. has inhibiting effect, wherein especially to staphylococcus aureus, Pseudomonas aeruginosa inhibiting effect It is most strong；In vitro test also shows that radix scutellariae plays the role of inhibiting Amoeba growth and kills Leptospira；Radix scutellariae also has Photoprotection, ultraviolet light (UVA, UVB) irradiation can cause skin keratin formation cell and fibroblast to damage, and radix scutellariae Cell activity can be made to restore 8%~38% after pretreatment, display radix scutellariae has light-protection energy, can reduce UVA, UVB to skin The damaging action of cell.

5, borneol: it is pungent, bitter, it is slightly cold.Inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain.For pyreticosis coma, convulsions, apoplexy coma due to blocking of the respiratory system, the obstruction of the circulation of vital energy is sudden and violent It faints, middle evil is gone into a coma, chest impediment and cardialgia, hot eyes, aphtha abscess of throat, purulent ear canal.Modern pharmacological research proves: borneol has anti- Bacterium, anti-inflammatory, analgesic activity, borneol, isoborneol and synthetic borneol have staphylococcus aureus, beta hemolytic streptococcus etc. There is antibacterial action, to contact bacteriostatic agent, three's antibacterial action is consistent, there is bacteriostasis in low concentration, and when high concentration kills Bacterium effect, time of contact extend, and antibacterial effect is stronger；Borneol also has inhibition to fungies such as microsporum fulvum, black-koji moulds or kills The effect of going out observes the black-koji mould after borneol effect by transmission electron microscope, and cell wall thickens, smudgy, intracellular Part organelle is destroyed；It is studied using aseptic inflammation model, discovery borneol, isoborneol can significantly inhibit rat caused by egg white Foot swelling, isoborneol have inhibiting effect to croton oil ear swelling, prompt them to the inflammation mistake such as the exudation of liquid and tissue edema Journey, which plays the role of inhibiting effect, borneol, may have antagonism PGE and inhibit inflammatory mediator release；Borneol can also promote drug to inhale Receive and promote Transdermal absorption: the facilitation of borneol is mainly in cuticula, it may be possible to due to borneol change lipid molecular arrangement and Caused by increasing its mobility, borneol also can increase intact skin and its destratum corneum skin Reservoir effect.

6, campanulaceae: it is pungent, it is mild-natured.Cough-relieving apophlegmatic, promoting the dispersing function of the lung, apocenosis.Modern pharmacological research proves, campanulaceae have enhance it is anti-inflammatory and Immunization, anti-inflammatory intensity are similar to aspirin；Water extract can enhance the phagocytic function of macrophage, and enhancing neutral white is thin The sterilizing power of born of the same parents improves lysozyme activity；Campanulaceae can also reduce allergic reaction.

7, Filifolium sibiricum: bitter, Xin Liang.It is clearing heat and detoxicating, relieving convulsion and calming the nerves, regulating menstruation, hemostasis.Infectious disease high fever is cured mainly, is taken orally to the heart Jump, insomnia, neurasthenia effect are significant, and to menorrhalgia, irregular menstruation also has certain curative effect.Swollen carbuncle, ulcer on the shank (lower limb are controlled in external application Chronic ulcer), tympanitis and other surgery pyogenic infection diseases.Modern pharmacological research proves that Filifolium sibiricum has antibacterial action, Antimicrobial test shows Filifolium sibiricum to staphylococcus aureus, staphylococcus albus, Pseudomonas aeruginosa, Escherichia coli, pneumonia bar The pathogenic bacteria of the common upper respiratory tract such as bacterium, proteus, shigella dysenteriae, beta hemolytic streptococcus, enteron aisle and trauma infection contamination There is antibacterial and bactericidal effect, especially to clinical common resistant Staphylococcus aureus, drug-resistant pseudomonas aeruginosa, drug resistance large intestine bar The primary formula bacterium of bacterium, drug resistance kerekou pneumonia still has antibacterial and bactericidal effect.

8, windproof: acrid flavour, sweet, slightly warm in nature.It expels pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, relieving convulsion.For exogenous disease exterior syndrome, rubella itch, wind Arthritis with fixed pain caused by dampness pain, tetanus just, the insufficiency of the spleen with overabundance of dampness.Modern pharmacological research proves, applies ear in croton oil and causes in scorching experiment, windproof decocting liquid energy Obvious to inhibit mice auricle swelling, inflammation caused by Dichlorodiphenyl Acetate also has apparent inhibiting effect；Windproof decocting liquid can reduce hair Thin vasopermeability and play anti-inflammatory effect；Radix saposhnikoviae to sensitized guinea pig isolated tracheal, ileum smooth muscle anaphylaxis shrink and 2, Delayed allergy caused by 4- dinitrofluorobenzene all has obvious inhibiting effect, to cavy anaphylaxis caused by ovalbumin Shock has certain protective effect, and radix saposhnikoviae causes cavy part itch, histamine caused by drug-induced mouse skin itch, histamine Capillary permeability increase and dimethyl sulfoxide caused by cavy ear swelling have inhibiting effect；The decocting of radix saposhnikoviae and its compound Liquid has the function of certain inhibitions influenza virus A3, in flat band method antibacterial experiment in vitro, it is windproof to staphylococcus aureus, Beta hemolytic streptococcus, Diplococcus pneumopniae and two kinds of enzyme bacterium (penicillium chrysogenum, variegated inulinase) etc. have inhibiting effect；Anti- wind energy The phagocytic activity for improving mouse macrophage has the function of enhancing non-specific immune function.

9, dark plum: it is sour, puckery, it puts down.Return liver, spleen, lung, large intestine channel.Astringing lung-QI, puckery intestines, promotes the production of body fluid, claming ascaris.For chronic cough of deficiency lung；It is empty Hot polydipsia；Chronic malaria；Chronic diarrhea；Dysentery；Hematochezia；Hematuria；Metrorrhagia；Ascariasis of biliary tract abdominal pain；Vomiting；Hookworm disease.Modern pharmacological research proves, black Plum decocting liquid (1:1) is (golden yellow, lemon yellow, white to bacillus anthracis, diphtheria and diphtheroid, hay bacillus, staphylococcus Color), pneumococcus all have inhibiting effect, to Escherichia coli, bacterium sonnei, proteus, Typhoid and paratyphoid bacillus, green The enterals pathogenic bacteria such as purulence bacillus, comma bacillus are also effective；50% decocting liquid is most strong to Bordetella pertussis and meningococcus effect, right Pneumococcus and hemolytic streptococcus effect are medium, also have an effect to ox type cloth bacillus and corynebacterium diphtheriae, and to Bacillus influenzae and Viridans streptococci is without effect；10% decocting liquid has inhibiting effect to various bacterias such as Escherichia coli, staphylococcuses；Dark plum ethanol extract All there is significant antibacterial action to some Grain-positives and negative bacteria and Bacillus tuberculosis；Dark plum powder is on plate to white Staphylococcus, hay bacillus, Escherichia coli and typhoid bacillus have strong effect；Infusion 1:80 (2 times of dilution methods) can inhibit bar The growth of family name bacillus.

10, Schisandra chinensis: acid, sweet, warm.Return lung, the heart, kidney channel.Astringing lung-QI, nourshing kidney are promoted the production of body fluid, and sweat, arresting seminal emission are received.The deficiency syndrome of the lung is controlled to breath with cough, Thirst, spontaneous perspiration, night sweat, internal lesion caused by overexertion is thin thin, emission, protracted dysentery and diarrhea.Modern pharmacological research proves that Schisandra chinensis has antibacterial Effect, Fructus Schisandrae Polysaccharide can significantly improve the phagocytic percentage and phagocytic index of normal mouse peritoneal macrophage, promote haemolysis The formation of element and hemolysis plaque promotes lymphocyte transformation, immune to enhancing to have preferable effect；Research also found simultaneously Schisandra chinensis Thick many candies, Schisandra chinensis water decoction can not only increasing leukocyte and enhancing immune function, and ring phosphorus can be significantly improved The reduction of amide induced mice peripheral white blood cells, while the weight of immunosuppressed mice thymus gland and spleen can be increased；The five tastes Son can promote the growth of beneficial bacterium to maintain intestinal microecology to balance, Schisandra chinensis contains polyenoid by inhibiting harmful intestinal tract bacteria Class compound, with fungal cell membrane ergosterol generate Irreversible binding, increase permeability of cell membranes, intracellular potassium from The living matters such as son and glucose, amino acid leak out, and have blocked the eubolism of fungi, have reached bacteriostasis；Schisandra chinensis is to big The fungistatic effect that the uncommon bacterium of intestines angstrom produces ESBLs plants and do not produce ESBLs plants does not have difference, and bacterium generates drug resistance mechanism the most universal It is to obtain R-plasmid, can be taken a turn for the worse with the elimination of R-plasmid by plasmid-mediated drug resistance.Using meat soup two Times dilution method research discovery Schisandra chinensis to the clinical multiple antibiotic resistant strain such as Escherichia coli, staphylococcus aureus, salmonella External R plasmid have different degrees of elimination effect.

11, hawthorn: there is the effect of promoting digestion and removing indigestion, scattered stasis.Cure mainly eating accumulation, diarrhea dysentery abdominal pain, hernia pain, stasis blocking Chest and abdomen pain, dysmenorrhea.Modern pharmacological research proves that hawthorn has stronger antibacterial action to shigella dysenteriae etc.；To Staphylococcus aureus Bacterium, beta streptococcus, Escherichia coli, proteus, bacillus anthracis, corynebacterium diphtheriae, typhoid bacillus, Pseudomonas aeruginosa etc. also have antibacterial Effect；And antibacterial experiment in vitro proves, haw thorn extract has good antibacterial sensitizing activity.

Compared to the prior art, the invention has the benefit that

The surfactant that the present invention uses is environmental type surfactant, non-stimulated to human skin, is not easy to produce Raw allergy, and biological degradability is high；

Disinfectant provided by the invention, as component, is suitable for easy to organic solvents such as ethyl alcohol without organic solvents such as ethyl alcohol The crowd of allergy；

The present invention separates the easy dyeings substances such as chlorophyll in Chinese medicine extract during preparing disinfectant, The problem of avoiding easy dyeing when in use；

The present invention uses the extract of Chinese herb as main antibacterial and sterilization component, wherein with folium artemisiae argyi, dandelion And radix scutellariae is monarch drug in a prescription, clearing heat and detoxicating, removing dampness to stop itchin, folium artemisiae argyi and radix scutellariae compatibility, moreover it is possible to inhibit succinic acid dehydrogenation in tricarboxylic acid cycle The activity of enzyme and malic dehydrogenase leads to nucleic acid biosynthesis block, to have the function that antibacterial, and folium artemisiae argyi and dandelion, Chinese mugwort Leaf and radix scutellariae compatibility can enhance bacteriostatic activity, and there are also photoprotections for radix scutellariae, may be to skin when being effective against ultraviolet disinfection Damage caused by skin cell；Using Filifolium sibiricum, radix saposhnikoviae, cordate houttuynia as ministerial drug, principal drug assistance heat-clearing, clearing damp, removing toxic substances the benefits of, radix saposhnikoviae again energy Cooperate with radix scutellariae, restore the sensibility of some antibiotic, has the function that reversal of drug resistance, Filifolium sibiricum is to clinical common drug resistance Bacterium still has antibacterial and bactericidal effect, and cordate houttuynia also has the function of removing necrosis and promoting granulation, and has well more to the skin injury surface of a wound Cooperation is used；It is to make medicine with dark plum, campanulaceae, Schisandra chinensis and hawthorn, dark plum and Schisandra chinensis are used cooperatively, the work with drug resistance inversion With the drug resistance of antibiotic can be restored, campanulaceae and cordate houttuynia, radix saposhnikoviae, Schisandra chinensis joint, moreover it is possible to enhance body and resist exopathogen Ability effectively antagonizes allergic reaction, and campanulaceae also has the function of enhancing folium artemisiae argyi antiallergy medium, and hawthorn has anti-well Bacterium effect of enhanced sensitivity can enhance the antibacterial action of the party with other medicines compatible use；It is again to make medicine with borneol, borneol is anti- While bacterium, have the function of promoting Drug Percutaneous Absorption, full presciption medicine object can be made to reach site of action, enhances antibacterial and sterilization and make With.Complete square compatibility 5 can effectively play antibacterial and bactericidal effect, and can enhance the drug resistance of drug, and have to part antibiotic Drug resistance inversion effect.

Specific embodiment

In order to enable those skilled in the art to more fully understand, technical solution of the present invention is practiced, below with reference to specific The invention will be further described for embodiment, but illustrated embodiment is not as a limitation of the invention.

Embodiment 1

A kind of environment-friendly type Chinese medicine compound prescription hand disinfectant, is made of the following components according to parts by weight: fatty alcohol polyoxy second 15 parts of alkene ether carboxylic acid sodium, 50 parts of Chinese medicine extract, 0.5 part of glycerol, 0.2 part of sodium benzoate, 0.5 part of orange essence, sodium chloride 1.5 Part, 20 parts of deionized water；

Wherein, Chinese medicine extract is made of the following components according to parts by weight: 15 parts of folium artemisiae argyi, 15 parts of dandelion, Filifolium sibiricum 10 parts, 15 parts of radix scutellariae, windproof 10 parts, 8 parts of dark plum, 8 parts of campanulaceae, 10 parts of cordate houttuynia, 5 parts of Schisandra chinensis, 5 parts of hawthorn, 3 parts of borneol.

Specifically prepared according to following steps:

Step 1 weighs 15 parts of folium artemisiae argyi, 15 parts of dandelion, 10 parts of Filifolium sibiricum, 15 parts of radix scutellariae, radix saposhnikoviae 10 in parts by weight Part, 8 parts of dark plum, 8 parts of campanulaceae, 10 parts of cordate houttuynia, 5 parts of Schisandra chinensis, 5 parts of hawthorn, 3 parts of borneol；

Step 2, by folium artemisiae argyi weighed in step 1, dandelion, Filifolium sibiricum, radix scutellariae, radix saposhnikoviae, dark plum, campanulaceae, cordate houttuynia, five Taste, hawthorn are uniformly mixed, and are added are equivalent to 12 times of its total weight deionized waters measured for the first time, 60 DEG C of refluxing extraction 3.0h, First time filtrate is collected in filtering；Filter residue, which is added, is equivalent to 10 times of its total weight deionized waters measured, 60 DEG C of refluxing extraction 1.0h, Second of filtrate is collected in filtering；Merge filtrate twice, is condensed into the solution that relative density is 1.05 under room temperature, it is spare；

Concentrate obtained in step 2 is added in D101 macroporous resin adsorption column step 3, adds and is equivalent to concentration The ethanol solution that liquid product is 50 times of amounts and mass fraction is 5% is eluted as eluant, eluent, elution flow rate 1mL/min, Eluent is collected, it is spare；

Step 5 weighs 15 parts of AEO carboxylic acid sodium, 50 parts of Chinese medicine extract, glycerol 0.5 in parts by weight Part, 0.2 part of sodium benzoate, 0.5 part of orange essence, 1.5 parts of sodium chloride, 20 parts of deionized water are spare；

AEO carboxylic acid sodium weighed in step 5 is heated to 70 DEG C of meltings by step 6, after being down to 40 DEG C Again after mixing with glycerol, sodium benzoate, orange essence, sodium chloride, deionized water, Chinese medicine obtained in step 4 is added to mention Liquid is taken, is stirred evenly to get Chinese medicine compound prescription hand disinfectant.

Embodiment 2

A kind of environment-friendly type Chinese medicine compound prescription hand disinfectant, is made of the following components according to parts by weight: 25 parts of behenic acid, 60 parts of Chinese medicine extract, 1.5 parts of glycerol, 0.5 part of sodium benzoate, 1.0 parts of Mint Essence, 2.0 parts of sodium chloride, deionized water 25 Part；

Wherein, Chinese medicine extract is made of the following components according to parts by weight: 25 parts of folium artemisiae argyi, 25 parts of dandelion, Filifolium sibiricum 20 parts, 25 parts of radix scutellariae, windproof 20 parts, 15 parts of dark plum, 15 parts of campanulaceae, 20 parts of cordate houttuynia, 8 parts of Schisandra chinensis, 8 parts of hawthorn, borneol 5 Part.

Specifically prepared according to following steps:

Step 1 weighs 25 parts of folium artemisiae argyi, 25 parts of dandelion, 20 parts of Filifolium sibiricum, 25 parts of radix scutellariae, radix saposhnikoviae 20 in parts by weight Part, 15 parts of dark plum, 15 parts of campanulaceae, 20 parts of cordate houttuynia, 8 parts of Schisandra chinensis, 8 parts of hawthorn, 5 parts of borneol；

Step 2, by folium artemisiae argyi weighed in step 1, dandelion, Filifolium sibiricum, radix scutellariae, radix saposhnikoviae, dark plum, campanulaceae, cordate houttuynia, five Taste, hawthorn are uniformly mixed, and are added are equivalent to 20 times of its total weight deionized waters measured for the first time, 85 DEG C of refluxing extraction 1.5h, First time filtrate is collected in filtering；Filter residue, which is added, is equivalent to 6 times of its total weight deionized waters measured, 85 DEG C of refluxing extraction 1.0h, Second of filtrate is collected in filtering；Merge filtrate twice, is condensed into the solution that relative density is 1.15 under room temperature, it is spare；

Concentrate obtained in step 2 is added in D101 macroporous resin adsorption column step 3, adds and is equivalent to concentration The ethanol solution that the mass fraction of 80 times of liquid product is 10% is eluted as eluant, eluent, and elution flow rate 1mL/min is collected Eluent, it is spare；

Step 5 weighs 25 parts of behenic acid, 60 parts of Chinese medicine extract, 1.5 parts of glycerol, sodium benzoate 0.5 in parts by weight Part, 1.0 parts of Mint Essence, 2.0 parts of sodium chloride, 25 parts of deionized water are spare；

Step 6 mixes behenic acid weighed in step 5, glycerol, sodium benzoate, Mint Essence, sodium chloride and deionized water After closing uniformly, Chinese medicine extract obtained in step 4 is added, stirs evenly to get Chinese medicine compound prescription hand disinfectant.

Embodiment 3

A kind of environment-friendly type Chinese medicine compound prescription hand disinfectant, is made of the following components according to parts by weight: alkyl polydextrose 22 parts of glycosides, 54 parts of Chinese medicine extract, 1.5 parts of glycerol, 0.5 part of sodium benzoate, 0.8 part of Mint Essence, 1.8 parts of sodium chloride, go from 22 parts of sub- water；

Wherein, Chinese medicine extract is made of the following components according to parts by weight: 22 parts of folium artemisiae argyi, 25 parts of dandelion, Filifolium sibiricum 15 parts, 20 parts of radix scutellariae, windproof 18 parts, 12 parts of dark plum, 15 parts of campanulaceae, 15 parts of cordate houttuynia, 6 parts of Schisandra chinensis, 8 parts of hawthorn, borneol 5 Part.

Specifically prepared according to following steps:

Step 1 weighs 22 parts of folium artemisiae argyi, 25 parts of dandelion, 15 parts of Filifolium sibiricum, 20 parts of radix scutellariae, radix saposhnikoviae 18 in parts by weight Part, 12 parts of dark plum, 15 parts of campanulaceae, 15 parts of cordate houttuynia, 6 parts of Schisandra chinensis, 8 parts of hawthorn, 5 parts of borneol；

Step 2, by folium artemisiae argyi weighed in step 1, dandelion, Filifolium sibiricum, radix scutellariae, radix saposhnikoviae, dark plum, campanulaceae, cordate houttuynia, five Taste, hawthorn are uniformly mixed, and are added are equivalent to 15 times of its total weight deionized waters measured for the first time, 75 DEG C of refluxing extraction 2.5h, First time filtrate is collected in filtering；The deionized water for being equivalent to 8 times of its total weight amounts, 75 DEG C of refluxing extraction 2.0h, mistake is added in filter residue Second of filtrate is collected in filter；Merge filtrate twice, is condensed into the solution that relative density is 1.10 under room temperature, it is spare；

Concentrate obtained in step 2 is added in D101 macroporous resin adsorption column step 3, adds and is equivalent to concentration The ethanol solution that the mass fraction of liquid 60 times of amounts of product is 8% is eluted as eluant, eluent, and elution flow rate 1mL/min is received Collect eluent, it is spare；

Step 5 weighs 22 parts of alkyl poly glucoside, 54 parts of Chinese medicine extract, 1.5 parts of glycerol, benzene first in parts by weight 0.5 part of sour sodium, 0.8 part of Mint Essence, 1.8 parts of sodium chloride, 22 parts of deionized water, it is spare；

Step 6, alkyl poly glucoside weighed in step 5 is heated to 70 DEG C melting, be down to after 40 DEG C again with glycerol, After mixing, Chinese medicine extract obtained in step 4, stirring is added in sodium benzoate, Mint Essence, sodium chloride and deionized water Uniformly to get Chinese medicine compound prescription hand disinfectant.

Comparative example 1

Wherein, Chinese medicine extract is made of the following components according to parts by weight: 22 parts of folium artemisiae argyi, 25 parts of dandelion, Filifolium sibiricum 15 parts, windproof 18 parts, 12 parts of dark plum, 15 parts of campanulaceae, 6 parts of Schisandra chinensis, 8 parts of hawthorn.

Specifically prepared according to following steps:

Step 1 weighs 22 parts of folium artemisiae argyi, 25 parts of dandelion, 15 parts of Filifolium sibiricum, windproof 18 parts, dark plum 12 in parts by weight Part, 15 parts of campanulaceae, 6 parts of Schisandra chinensis, 8 parts of hawthorn；

Step 2 mixes folium artemisiae argyi weighed in step 1, dandelion, Filifolium sibiricum, radix saposhnikoviae, dark plum, campanulaceae, Schisandra chinensis, hawthorn It closes uniformly, the deionized waters for being equivalent to 15 times of its total weight amounts, 75 DEG C of refluxing extraction 2.5h is added for the first time, filtering collects the First-time filtrate；The deionized water for being equivalent to 8 times of its total weight amounts, 75 DEG C of refluxing extraction 2.0h is added in filter residue, and filtering collects second Secondary filtrate；Merge filtrate twice, is condensed into the solution that relative density is 1.10 under room temperature, it is spare；

Eluent obtained in step 3 is concentrated into 1mg/mL by step 4, obtains Chinese medicine extract；

Step 6 by alkyl poly glucoside weighed in step 5, glycerol, sodium benzoate, Mint Essence, sodium chloride and is gone Ionized water after mixing, is added Chinese medicine extract obtained in step 4, stirs evenly to get Chinese medicine compound prescription hand disinfectant.

Comparative example 2

Wherein, Chinese medicine extract is made of the following components according to parts by weight: 25 parts of dandelion, 15 parts of Filifolium sibiricum, radix scutellariae 20 parts, 12 parts of dark plum, 15 parts of cordate houttuynia, 6 parts of Schisandra chinensis, 5 parts of borneol.

Specifically prepared according to following steps:

Step 1 weighs 25 parts of dandelion, 15 parts of Filifolium sibiricum, 20 parts of radix scutellariae, 12 parts of dark plum, cordate houttuynia 15 in parts by weight Part, 6 parts of Schisandra chinensis, 5 parts of borneol；

Dandelion weighed in step 1, Filifolium sibiricum, radix scutellariae, dark plum, cordate houttuynia, Schisandra chinensis are uniformly mixed by step 2, the It is primary that the deionized water for being equivalent to 15 times of its total weight amounts, 75 DEG C of refluxing extraction 2.5h, filtering, collection first time filtrate is added； The deionized water for being equivalent to 8 times of its total weight amounts, 75 DEG C of refluxing extraction 2.0h is added in filter residue, and second of filtrate is collected in filtering；It closes And filtrate twice, it is condensed into the solution that relative density is 1.10 under room temperature, it is spare；

Comparative example 3

Wherein, Chinese medicine extract is made of the following components according to parts by weight: 22 parts of folium artemisiae argyi, 25 parts of dandelion, radix scutellariae 20 Part, windproof 18 parts, 12 parts of dark plum, 15 parts of campanulaceae, 15 parts of cordate houttuynia, 8 parts of hawthorn, 5 parts of borneol.

Specifically prepared according to following steps:

Step 1 weighs 22 parts of folium artemisiae argyi, 25 parts of dandelion, 20 parts of radix scutellariae, windproof 18 parts, 12 parts of dark plum, tangerine in parts by weight Obstruct 15 parts, 15 parts of cordate houttuynia, 8 parts of hawthorn, 5 parts of borneol；

Step 2 mixes folium artemisiae argyi weighed in step 1, dandelion, radix scutellariae, radix saposhnikoviae, dark plum, campanulaceae, cordate houttuynia, hawthorn Uniformly, the deionized water for being equivalent to 15 times of its total weight amounts, 75 DEG C of refluxing extraction 2.5h are added for the first time, filtering collects first Secondary filtrate；The deionized water for being equivalent to 8 times of its total weight amounts, 75 DEG C of refluxing extraction 2.0h is added in filter residue, and filtering collects second Secondary filtrate；Merge filtrate twice, is condensed into the solution that relative density is 1.10 under room temperature, it is spare；

The disinfectant that the various embodiments described above and comparative example are obtained carries out sense organ, physical and chemical index, validity period, microorganism respectively Index, antibacterial index, sterilization index and toxicologic index detection.

1, the sense organ of product, physical and chemical index, validity period and toxicologic index testing result are shown in Table 1.

The sense organ of the invention of table 1, physical and chemical index, validity period and toxicologic index testing result

2, product microbial indicators detected the results are shown in Table 2.

2 product microbial indicators detected result of table

It combines table 2 it is found that the safe and non-stimulating property of Chinese medicine compound prescription hand disinfectant provided by the present application by table 1, and has fine Restraining and sterilizing bacteria effect.

3, drug resistance is tested

According to NCCLS standard, measure clinical common bacteria Escherichia coli, staphylococcus glucose coccus, Candida albicans and The drug resistance for the disinfectant that natural bacteria provides above-mentioned each embodiment and comparative example, by measuring disk diffusion method, measurement suppression Bacterium loop diameter.

The results show that the size of inhibition zone is between 15~20mm in embodiments, inhibition zone in each comparative example Diameter illustrates disinfectant provided by the present application to clinical common bacteria Escherichia coli, staphylococcus glucose bar between 9~13mm Bacterium, Candida albicans and natural bacteria have preferable drug resistance.

It should be noted that involved in claims of the present invention when numberical range, it is thus understood that each numberical range Any one numerical value can be selected between two endpoints and two endpoints, due to step method and the Examples 1 to 3 phase of use Together, it repeats in order to prevent, the present invention describes preferred embodiment, and once a person skilled in the art knows basic wounds The property made concept, then additional changes and modifications may be made to these embodiments.So the following claims are intended to be interpreted as includes Preferred embodiment and all change and modification for falling into the scope of the invention.

Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art Mind and range.In this way, if these modifications and changes of the present invention belongs to the range of the claims in the present invention and its equivalent technologies Within, then the present invention is also intended to include these modifications and variations.

Claims

1. a kind of environment-friendly type Chinese medicine compound prescription hand disinfectant, which is characterized in that be made of the following components according to parts by weight: surface is living 15~25 parts of agent of property, 50~60 parts of Chinese medicine extract, 0.5~1.5 part of glycerol, 0.2~0.5 part of sodium benzoate, essence 0.5~ 1.0 parts, 1.5~2.0 parts of sodium chloride, 20~25 parts of deionized water；

Wherein, the Chinese medicine extract is made of the following components according to parts by weight: 15~25 parts of folium artemisiae argyi, dandelion 15~25 Part, 10~20 parts of Filifolium sibiricum, 15~25 parts of radix scutellariae, windproof 10~20 parts, 8~15 parts of dark plum, 8~15 parts of campanulaceae, cordate houttuynia 10 ~20 parts, 5~8 parts of Schisandra chinensis, 5~8 parts of hawthorn, 3~5 parts of borneol.

2. environment-friendly type Chinese medicine compound prescription hand disinfectant according to claim 1, which is characterized in that according to parts by weight by following Component is made: 22 parts of surfactant, 54 parts of Chinese medicine extract, 1.5 parts of glycerol, 0.5 part of sodium benzoate, 0.8 part of essence, chlorination 1.8 parts of sodium, 22 parts of deionized water；

Wherein, the Chinese medicine extract is made of the following components according to parts by weight: 22 parts of folium artemisiae argyi, 25 parts of dandelion, Filifolium sibiricum 15 parts, 20 parts of radix scutellariae, windproof 18 parts, 12 parts of dark plum, 15 parts of campanulaceae, 15 parts of cordate houttuynia, 6 parts of Schisandra chinensis, 8 parts of hawthorn, borneol 5 Part.

3. environment-friendly type Chinese medicine compound prescription hand disinfectant according to claim 1 or 2, which is characterized in that the surfactant For in AEO carboxylic acid sodium, polyglyceryl fatty acid ester, alkyl poly glucoside, modified grease and vegetable oil acid It is one or more of.

4. environment-friendly type Chinese medicine compound prescription hand disinfectant according to claim 3, which is characterized in that the vegetable oil acid is soya-bean oil One or more of acid, cotton oil acid and rape oil acid.

5. environment-friendly type Chinese medicine compound prescription hand disinfectant according to claim 1 or 2, which is characterized in that the essence is water-soluble Property essence.

6. the preparation method of environment-friendly type Chinese medicine compound prescription hand disinfectant according to claim 1, which is characterized in that specifically include Following steps:

Step 1 weighs 15~25 parts of folium artemisiae argyi, 15~25 parts of dandelion, 10~20 parts of Filifolium sibiricum, radix scutellariae 15~25 in parts by weight Part, windproof 10~20 parts, 8~15 parts of dark plum, 8~15 parts of campanulaceae, 10~20 parts of cordate houttuynia, 5~8 parts of Schisandra chinensis, hawthorn 5~8 Part, 3~5 parts of borneol；

Step 2, by folium artemisiae argyi weighed in step 1, dandelion, Filifolium sibiricum, radix scutellariae, radix saposhnikoviae, dark plum, campanulaceae, cordate houttuynia, the five tastes Son, hawthorn are uniformly mixed, and the deionized water for being equivalent to 12~20 times of its total weight amounts is added for the first time, and 60 DEG C~85 DEG C reflux mention 1.0~3.0h is taken, is filtered, first time filtrate is collected；Filter residue, which is added, is equivalent to 6~10 times of its total weight deionized waters measured, and 60 DEG C~85 DEG C of 1.0~3.0h of refluxing extraction, filtering, second of filtrate of collection；Merge filtrate twice, is condensed into relatively close under room temperature The solution that degree is 1.05~1.15, it is spare；

Step 3 will carry out absorb-elute in the addition macroporous resin adsorption column of concentrate obtained in step 2, and eluant, eluent is quality The ethanol solution that score is 5~10%, elution flow rate 1mL/min collect eluent, spare；

Eluent obtained in step 3 is concentrated into 1mg/mL by step 4, then by borneol and grinding weighed in step 1 at superfine Powder is added in the eluent after being concentrated, stirs evenly, obtain Chinese medicine extract；

Step 5, weigh in parts by weight 15~25 parts of surfactant, 50~60 parts of Chinese medicine extract, 0.5~1.5 part of glycerol, 0.2~0.5 part of sodium benzoate, 0.5~1.0 part of essence, 1.5~2.0 parts of sodium chloride, 20~25 parts of deionized water, it is spare；

Step 6, surfactant weighed in step 5 is heated to 70 DEG C melting, be down to after 40 DEG C again with glycerol, benzoic acid Sodium, essence, sodium chloride and deionized water are uniformly mixed, and Chinese medicine extract obtained in step 4 is added, stirs evenly to get in Medicine compound hand disinfectant.

7. the preparation method of environment-friendly type Chinese medicine compound prescription hand disinfectant according to claim 6, which is characterized in that in step 2 The reflux temperature is 75 DEG C, and the return time is flow back for the first time 2.5h, second of reflux 2.0h.

8. the preparation method of environment-friendly type Chinese medicine compound prescription hand disinfectant according to claim 6, which is characterized in that in step 3 The dosage of eluant, eluent is 50~80 times of concentrate dosage.

9. the preparation method of environment-friendly type Chinese medicine compound prescription hand disinfectant according to claim 6, which is characterized in that the macropore Resin is D101 macroreticular resin.