CN105079305A - Antisepsis and anti-inflammation external traditional Chinese medicine compound gel and preparation method thereof - Google Patents
Antisepsis and anti-inflammation external traditional Chinese medicine compound gel and preparation method thereof Download PDFInfo
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Abstract
The invention provides antisepsis and anti-inflammation external traditional Chinese medicine compound gel and a preparation method thereof. The antisepsis and anti-inflammation external traditional Chinese medicine compound gel is mainly prepared from rumex crispus, philippine violet herb, radix scutellariae, flos carthami, fructus cnidii and rhizoma atractylodis by a scientific processing technology, has broad-spectrum antibacterial activities, particularly has a good sterilizing effect for bacteria and fungus which cause diseases such as beriberi and olliculitis, and also has effects of promoting wound healing and eliminating acne marks. A test proves that various medicinal materials in the antisepsis and anti-inflammation external traditional Chinese medicine compound gel are compatible and play effects cooperatively, and the antisepsis and anti-inflammation external traditional Chinese medicine compound gel is an effective prescription for treating beriberi and dermatoses.
Description
Technical field
The invention provides a kind of anti-inflammation external application Chinese medicine compound gel and preparation method thereof, belong to traditional Chinese medical science pharmaceutical technology sectors.
Background technology
Chlosma (Malassezia) be a class parasitize humans and animals normal skin surface addicted to fat yeast-like fungi, opportunistic infection (n can be caused.Chlosma infects and not only directly causes tinea versicolor (pityriasisversicolor, PV), Malassezia folliculits (Malasseziafolliculitis, MF), also be the important virulence factor of dandruff dermatitis (Seborrheicdermatitis, SD), atoipc dermatitis, psoriasis and skin ulcer of fullying recover from an illness simultaneously.
Document display both domestic and external, there is larger difference in the Malassezia distribution situation in human body different parts, different sexes, all ages and classes, different regions and Various Seasonal not of the same race, the distribution proportion that chlosma is not of the same race in different crowd also exists difference.Tinea versicolor, Malassezia folliculits, the seborrheic dermatitis common skin diseases all for being caused by chlosma.
At present, China's traditional medicine or Chinese medicine (comprising folk prescription among the people) have the dermopathic medicine of many treatments, but effect and the preparation method for the treatment of are not quite similar, Different therapeutical effect is large, some medicine can only control table, can not effectively neutralize a toxin and control poison, worm, dirty diffusion, not reach the object of effecting a permanent cure and curing.If use the dosage forms such as the ointment of doctor trained in Western medicine to treat, they also exist certain side effect, and what have treats halfway problem in addition, and cure rate is subject to certain impact, and the also existence had easily is recurred, problem repeatedly.
Summary of the invention
The invention provides a kind of anti-inflammation external application Chinese medicine compound gel, be mainly used in treating all kinds of dermatosiss that caused by antibacterial, fungus and virus, there is good fungistatic effect, have no side effect, instant effect, cure rate be high.
The present invention further provides a kind of preparation method of anti-inflammation external application Chinese medicine compound gel, be applicable to suitability for industrialized production.
A kind of anti-inflammation external application Chinese medicine compound gel of the present invention, it is characterized in that being made up by ratio of weight and the number of copies of following medicine:
Yang Tie blade root 10-18, Herba Violae 3-12, Radix Scutellariae 4-10, Flos Carthami 4-10, Fructus Cnidii 3-8, Rhizoma Atractylodis 2-6.
The preparation method of a kind of anti-inflammation external application Chinese medicine compound gel of the present invention, comprises the following steps:
Take Yang Tie blade root, Herba Violae, Radix Scutellariae, Flos Carthami, Fructus Cnidii, Rhizoma Atractylodis in proportion, Chinese crude drug is put into reflux, in container, add Chinese medicine weight 10-20 water doubly, soak 1-3h, heating and refluxing extraction 1-3 time, merges each filtrate decocted, obtains Chinese medicine extraction liquid; Getting 2-10 part sodium carboxymethyl cellulose (viscosity is greater than 1200mPa.s) swells in extracting solution, spends the night; Get 2-5 part Borneolum Syntheticum to be dissolved in 3-10 part dehydrated alcohol, be prepared into Borneolum Syntheticum alcoholic solution; Get dodecyl sodium sulfate 2-5 part, glycerol 5-20 part, ethyl hydroxybenzoate 1-3 part, Borneolum Syntheticum alcoholic solution 3-10 part adds in Chinese medicine extraction liquid, high-speed stirred is even, gets product.
[usage and dosage]external, every day uses 2-3 time, after medication, massages a little, makes it absorb completely, finally consolidates 5-7 days; For skin injury place, before smearing, cleaning wound is clean.
[indication]belong to anti-(pressing down) bacteria preparation, can directed toward bacteria, fungus-caused beriberi, foot odor, the foot problems such as paronychia; The bacteriological infection that burn and scald, acne cause; Also there is Quick itch stopping, tinea of going out, the effect such as antiinflammatory and removing the necrotic tissue and promoting granulation.
the side of Traditional Chinese medicine compound gel of the present invention separates:
In the present invention, monarch drug is Yang Tie blade root, and Yang Tieye, cures mainly heat-clearing and toxic substances removing, hemostasis, blood stasis dispelling, relieving constipation, parasite killing.Experiment in vitro proves tubercule bacillus, escherichia coli, Bacillus proteus, bacillus pyocyaneus, Jin Shi trichophyton, and the various skin funguses such as Trichophyton concentricunm all have inhibitory action.Ministerial drug is Herba Violae, Radix Scutellariae; Herba Violae: feeble QI is loose to be let out; There is heat-clearing and toxic substances removing, effect of removing heat from blood detumescence; Cure mainly furuncle carbuncle, mumps, scrofula, erysipelas, acute mastitis, acute appendicitis, damp and hot and dysentery, jaundice, conjunctival congestion and swelling pain, sore throat, venom; Radix Scutellariae: heat-clearing and toxic substances removing; Loose tired hemostasis; Inducing diuresis to remove edema.Cure mainly pyretic toxicity carbuncle; Have sore throat; Lung abscess; Intestinal carbuncle; Cold disease; Spit blood; Maggot blood; Stranguria with blood; Edema; Ascites and cancer.Modern medicine study confirms, Radix Scutellariae has broad-spectrum antibacterial action.Two medicines are minister, strengthen monarch drug effect.Employing Flos Carthami, Fructus Cnidii are adjuvant drug; Flos Carthami has promoting blood circulation to restore menstrual flow, effect of eliminating stasis to stop pain; Fructus Cnidii warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing, and the drug effect of the monarch and his subjects strengthened by two medicines.Rhizoma Atractylodis for making medicine, Rhizoma Atractylodis: drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, have loose bowels, edema, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Described in the present invention, all medicines complement each other, and play synergism, and common composition treats all kinds of dermopathic good recipe caused by antibacterial, fungus and virus.
the present invention has following beneficial effect:
1. compared with other products of disinfection field, there is the characteristic of natural drug, determined curative effect, there is no many harmful effects and the side effect of chemicals.2. compare compared with the like product of Chinese medicine extract, not there is bad smell and outward appearance.3. easy to use, percutaneous permeability is good, nonirritant, and performance of keeping humidity is good, not easily remains, and do not need with other drug with the use of.4. the present invention has the bacteriostatic activity of wide spectrum, particularly for causing the antibacterial of the disease such as beriberi, folliculitis, fungus etc. all to have very strong bactericidal effect, there is again the effect promoting wound healing, eliminate pox print, by the mutual compatibility of ingredients, collaborative volatilization in test confirmation side, become the good recipe for the treatment of beriberi, dermatosis.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated
embodiment 1
Take Chinese medicine composition: Yang Tie blade root 10g, Herba Violae 3g, Radix Scutellariae 4g, Flos Carthami 4g, Fructus Cnidii 3g, Rhizoma Atractylodis 2g.Chinese crude drug is put into reflux, in container, adds the water of Chinese medicine weight 10 times, soak 1h, heating and refluxing extraction 2 times, merge each filtrate decocted, obtain Chinese medicine extraction liquid; Getting 20g sodium carboxymethyl cellulose (viscosity is greater than 1200mPa.s) swells in extracting solution, spends the night; Get 3g Borneolum Syntheticum to be dissolved in 10mL dehydrated alcohol, be prepared into Borneolum Syntheticum alcoholic solution; Get dodecyl sodium sulfate 2g, glycerol 15g, ethyl hydroxybenzoate 2g, Borneolum Syntheticum alcoholic solution 10mL add in Chinese medicine extraction liquid, high-speed stirred is even, gets product.
embodiment 2
Take Chinese medicine composition: Yang Tie blade root 13g, Herba Violae 5g, Radix Scutellariae 6g, Flos Carthami 6g, Fructus Cnidii 5g, Rhizoma Atractylodis 2g.Chinese crude drug is put into reflux, in container, adds the water of Chinese medicine weight 15 times, soak 1h, heating and refluxing extraction 2 times, merge each filtrate decocted, obtain Chinese medicine extraction liquid; Getting 20g sodium carboxymethyl cellulose (viscosity is greater than 1200mPa.s) swells in extracting solution, spends the night; Get 3g Borneolum Syntheticum to be dissolved in 10mL dehydrated alcohol, be prepared into Borneolum Syntheticum alcoholic solution; Get dodecyl sodium sulfate 2g, glycerol 15g, ethyl hydroxybenzoate 2g, Borneolum Syntheticum alcoholic solution 10mL add in Chinese medicine extraction liquid, high-speed stirred is even, gets product.
embodiment 3
Take Chinese medicine composition: Yang Tie blade root 15g, Herba Violae 7g, Radix Scutellariae 8g, Flos Carthami 6g, Fructus Cnidii 5g, Rhizoma Atractylodis 5g.Chinese crude drug is put into reflux, in container, adds the water of Chinese medicine weight 10 times, soak 1h, heating and refluxing extraction 2 times, merge each filtrate decocted, obtain Chinese medicine extraction liquid; Getting 20g sodium carboxymethyl cellulose (viscosity is greater than 1200mPa.s) swells in extracting solution, spends the night; Get 3g Borneolum Syntheticum to be dissolved in 10mL dehydrated alcohol, be prepared into Borneolum Syntheticum alcoholic solution; Get dodecyl sodium sulfate 2g, glycerol 15g, ethyl hydroxybenzoate 2g, Borneolum Syntheticum alcoholic solution 10mL add in Chinese medicine extraction liquid, high-speed stirred is even, gets product.
embodiment 4
Take Chinese medicine composition: Yang Tie blade root 18g, Herba Violae 12g, Radix Scutellariae 10g, Flos Carthami 10g, Fructus Cnidii 8g, Rhizoma Atractylodis 6g.Chinese crude drug is put into reflux, in container, adds the water of Chinese medicine weight 20 times, soak 1h, heating and refluxing extraction 2 times, merge each filtrate decocted, obtain Chinese medicine extraction liquid; Getting 20g sodium carboxymethyl cellulose (viscosity is greater than 1200mPa.s) swells in extracting solution, spends the night; Get 3g Borneolum Syntheticum to be dissolved in 10mL dehydrated alcohol, be prepared into Borneolum Syntheticum alcoholic solution; Get dodecyl sodium sulfate 2g, glycerol 15g, ethyl hydroxybenzoate 2g, Borneolum Syntheticum alcoholic solution 10mL add in Chinese medicine extraction liquid, high-speed stirred is even, gets product.
Traditional Chinese medicine compound gel of the present invention is a kind of good effect, can effect a radical cure and the preparation for external application to skin do not recurred, and it is worth noting that the multiple medicinal ingredient in the present invention has played synergism after composite in drug effect.Described middle medicine composite preparation can form pharmaceutical preparation with pharmaceutically acceptable carrier or excipient, and described preparation can be the exterior-applied formulations such as spray, aerosol, cream, ointment, gel or wet tissue.
Curative effect of the present invention is proved further below by following model case
case 1
Xue, man, 39 years old, infects beriberi 6 years, and cardinal symptom performance has: moist rotten to the corn between toe, tumor is itched, and festers and casts off a skin, stream yellow fluid.Adopt embodiment 1 to treat, 3 days take effect, do not flow yellow fluid, after 5 days, no longer fester, and decortication obviously reduces, and after 15 days, transference cure, no longer festers, and no longer tumor is itched, and cure.Pay a return visit after 1 year, have no recurrence.
case 2
Feng, man, 52 years old, infects beriberi 14 years, and cardinal symptom performance has: vola portion tumor is itched hard to bear, and moist rotten to the corn between toe, bilateral heel skin keratin is thick casts off a skin.Adopt embodiment 2 to treat, 7 days take effect, no longer fester between toe, and heel decortication reduces, and after 18 days, transference cure, no longer casts off a skin, and no longer tumor is itched, and cures.Pay a return visit after 1 year, have no recurrence.
case 3
Soup, man, 34 years old, infects beriberi 2 years, and cardinal symptom performance has: heel skin keratin is firmly thick, yellow skin, and illing skin is coarse a large amount of desquamation, shame splits symptom.Adopt embodiment 3 to treat, 6 days take effect, and heel xerosis cutis is alleviated, and use 14 days continuously, and shame breach heals, and heel desquamation reduces, and use 25 days continuously, local skin deliquescing, and color recovers normal, cures.Pay a return visit after 1 year, have no recurrence.
case 4
Zhang, man, 28 years old, suffers from beriberi 4 years, and cardinal symptom performance has: tumor is itched, cast off a skin, tear, pain, adopt the embodiment of the present invention 2 to treat, sooner or later wiping 1 time, the same day pain relief, 6 days take effect, pain, transference cure of casting off a skin, continuous use 24 days, tearing port heals, and tumor is itched disappearances, healing.Pay a return visit after 1 year, have no recurrence.
case 5
Lin, female, 42 years old, infects beriberi 4 years, and cardinal symptom performance has: foot interphalangeal erosion, tumor is itched, and festers and casts off a skin.Adopt the embodiment of the present invention 4 to treat, 3 days take effect, and phenomenon minimizing of casting off a skin of festering, after 5 days, no longer fester and cast off a skin, after 15 days, transference cure, no longer festers, and no longer tumor is itched, and cures.Pay a return visit after 1 year, have no recurrence.
case 6
Jiang, man, 32 years old, suffer from beriberi 12 years, cardinal symptom performance have: pain, tumor are itched, cast off a skin, are torn, adopt the embodiment of the present invention 3 treat, the same day pain relief, 8 days take effect, pain, tumor are itched, transference cure of casting off a skin, and use 28 days continuously, and tearing port is fully recovered, local skin color recovers normal, cures.Pay a return visit after 1 year, have no recurrence.
case 7
XX catches by bacterial cutization grasserie disease recklessly, and before using, the sufferer order of severity is after testing +++, use embodiment 3 one week continuously, once a day, through detecting after the week, inflammation is cured, and has no recurrence.
case 8
Open X, women, 48 years old, the tinea pedis that fungal infection causes, before using, the sufferer order of severity is after testing ++, using embodiment 2 one months continuously, once a day, through detecting after one month, having no recurrence.
case 9
Xiao X, women, 25 years old, through chemical examination for facial acne, before using, the sufferer order of severity was after testing ++++, use embodiment 1 two weeks continuously, once a day, through detecting after two weeks, assay be symptom degree become+, take an evident turn for the better sign.
case 10
King XX, women, suffer from folliculitis, before using, the sufferer order of severity is after testing +++, use the embodiment of the present invention 1 continuously, use 10, once a day, after 10 days, diagnostic result is that symptom disappears completely.
case 11
To XX, women, does not heal for sores ulceration of skin and skin infection after diagnosing, uses the embodiment of the present invention 2 continuously, uses 3 months, and once a day, through detecting after 3 months, ill symptoms is all vanished from sight.
case 12
Zhao XX catches the tinea versicolor caused by chlosma, and before using, the sufferer order of severity is after testing ++++, use yellow skin skin gel on the market month continuously, every three days are once, and through detecting after one month, the sufferer order of severity is ++++, do not take a turn for the better sign; The continuous use embodiment of the present invention 2 one months, once a day, and treatments period isolation, through detecting after one month, fully recover.
case 13
Horse X, women, 32 years old, through the folliculitis that chemical examination causes for chlosma, before using, the sufferer order of severity was after testing ++, use market product skin to itch Wang Liangzhou continuously, once a day, through detection after two weeks, to be the assay sufferer order of severity be assay ++; In 4 liang of weeks of the continuous use embodiment of the present invention, once a day, through detecting after two weeks, symptom disappears completely, and checks after one month and do not recur sign.
case 14
Zhao XX catches the chickenpox caused by varicella zoster virus, before using, the sufferer order of severity is after testing ++++, continuous use skin gel on the market what a at once the moon, every three days once, through detecting after one month, the sufferer order of severity is ++++, do not take a turn for the better sign, and the skin illustrating on the market must be pacified gel and do not possessed antiviral effect; The continuous use embodiment of the present invention 4 one months, once a day, and treatments period isolation, through detecting after one month, fully recover.
case 15
Horse X, women, 32 years old, through the measles that chemical examination causes for Measles virus, before using, the sufferer order of severity is after testing ++, use continuously market product skin to itch Wang Liangzhou, once a day, through detecting after two weeks, to be the assay sufferer order of severity be assay ++, and to no effect; But continuously use 3 liang of weeks of the embodiment of the present invention, once a day, through detecting after two weeks, symptom disappears completely, and check after one month and do not recur sign.
extracorporeal bacteria inhibitor test
bacteriostatic test example 1
1, experiment material
Example two lg, adds normal saline and makes 2mL medicinal liquid; Example three 1g, adds normal saline and makes 2mL medicinal liquid; New ointment for tinea pedis (the Jiu Futang bio-pharmaceuticals of commercially available Guangzhou) is prepared into 20mg/mL solution (pH6.5); Middle medicine composite preparation group 2mL.Bacterial strain: trichophyton, trichophyton gypseum, acrothesium floccosum provide by Disease Control and Prevention Center of Jilin Province.
2, experimental technique
Sterilized agar culture medium is heated to and melts completely, be poured in culture dish, Mei Min 18mL(lower floor), treat that it solidifies.In addition, by the LB culture medium of thawing, (dextrose bouillon, ordinary nutrient agar culture medium, husky Bao Shi agar culture medium, bile salt lactose fermentation tube, smelling of cetrimonium are by agar culture medium, blood agar culture-medium, select different culture medium according to different strains, experimental technique is consistent.) be cooled to about 50 DEG C to be mixed into test organisms, the culture medium 5mL being mixed with bacterium is added to (upper strata) to be solidified in the culture medium of having solidified.Oxford cup (the circular tubule of internal diameter 6mm, external diameter 8mm, high lOmm is directly vertically put in media surface with sterile working, the two ends of pipe are smooth, also useable glass pipe, porcelain tube), pressurize gently, it is made to contact tight with culture medium, in cup, add measuring samples 100uL, do not make it excessive.Fill it up with rearmounted 37 DEG C of cultivations, observed result.The results are shown in Table 1:
Table 1: Antibacterial Activity result of the present invention
Description of test the present invention is higher for causing the trichophyton of beriberi, trichophyton gypseum, the equal bacteriostasis rate of Epidermophvton tinea.
bacteriostatic test example 2
The escherichia coli of-20 DEG C are inoculated in seed culture medium, are cultured to exponential phase (OD=0.6), get bacterium liquid dilute 20 times after for subsequent use.
Get plant polypeptide compound gel sample, put in the concentrator bowl containing 5mlPBS, add the rear bacteria suspension of 100ul dilution respectively, dandle concentrator bowl, starts timing, effect 2min, 5mlPBS is dropped into toward by test agent, abundant mixing, then extracts reaction solution, after diluting 10 times and 100 times, draw 0.5ml wherein respectively, be placed in 2 plates, pour into the cool LB solid medium 15ml to 40 DEG C ~ 50 DEG C, rotate plate, make it full and uniform, after agar solidification, upset is dull and stereotyped, cultivates 24h, does viable bacteria colony counting for 36 DEG C.Calculate ointment effect 2min to escherichia coli suppression ratio.Same method effect 5min, 10min.What matched group adopted is the good ointment of horse back on the market.Result shows, in effect 2min situation, case study on implementation 1 pair of escherichia coli bacteriostasis rate is 92.84%, case study on implementation 2 pairs of escherichia coli bacteriostasis rates are 88.66%, case study on implementation 3 pairs of escherichia coli bacteriostasis rates are 91.28%, case study on implementation 4 pairs of escherichia coli bacteriostasis rates are 89.67%, and case study on implementation 5 pairs of escherichia coli bacteriostasis rates are 90.98%.
As can be seen from experimental result, in 5 groups of case study on implementation after gel effect 2min, all can reach more than 85% to colibacillary suppression ratio, there is stronger bacteriostatic activity.
bacteriostatic test example 3
1. medicinal liquid dilution
Get sterile test tube 10, be numbered from 1-10, add sterile distilled water l0ml respectively in 2-10 pipe;
Chinese medicine extract stock solution 20ml obtained by Example 1 puts in No. 1 pipe, getting l0ml puts in No. 2 pipes, mixing, l0ml diluent is taken out again from No. 2 pipes, add in No. 3 pipes, mixing, doubling dilution discards to No. 9 pipe taking-up 10ml so continuously, and No. 10 pipe only has sterile distilled water to make blank.What matched group adopted is the good ointment of horse back on the market.
Use the same method and dilute the medicinal liquid of embodiment 2-4.
2. pastille flat board preparation
Under aseptic condition, the Chinese medicine extraction liquid stock solution 2m1 of variable concentrations is added on 9 flat boards respectively; then the M-H agar 18ml oneself dissolved pours into above-mentioned 9 flat boards respectively; mix homogeneously, make these 9 agar plate reality respectively containing Chinese medicine extraction liquid 10% (1:10), 5% (1:20), 2.5% (1:40), 1.25% (1:80), 0.625% (1:160), 0.313% (1:320), 0.156% (1:640), 0.078%n:1280), 0.039% (1:2560);
3. bacterium solution preparation
Methicillin-resistant staphylococcus aureus fresh cultured thing is made bacterium liquid, and concentration is equivalent to 0.5 Maxwell opacity tube
4. the inoculation of strain
Indicate drug level in the dull and stereotyped back side, draw 0.5ml bacterium liquid with multiple spot inoculation instrument and be inoculated on the agar plate containing different pharmaceutical concentration by bacterium liquid, not add the agar plate of medicinal liquid for contrast, act on 2min respectively, 5min, 10min calculate antibacterial percentage rate.
As can be seen from experimental result, after the Chinese medicine extraction liquid effect in 5 groups of case study on implementation, all fine to the bacteriostatic activity of methicillin-resistant staphylococcus aureus, there is stronger bacteriostatic activity.
bacteriostatic test example 4
Bacillus pyocyaneus is seeded on plain agar plate the previous day by test, is placed in 37 DEG C of calorstats and cultivates 24h, be made into the turbid concentration (turbidimetry) of every milliliter of about 300,000,000 bacterium with physiological saline solution.Bacterium liquid is soaked into aseptic cotton carrier, excessive bacterium liquid is pressurizeed in tube wall place and extrudes, evenly intensively be coated on plain agar planar surface, after bacterium liquid is dry, punch with 5mm card punch, then add embodiment 1-5 medicinal liquid and matched group respectively in hole, what matched group adopted is the good ointment of horse back on the market, is placed on observed result in calorstat.
bacteriostatic test example 5
The plate of drug sensitive test is adopted to burrow method, namely dip with sterilized cotton swabs and whitely read coccus liquid, be uniformly coated on Nutrient agar plate, then with the punching of diameter 6mm card punch, remove agar in hole and suitably seal hole up for safekeeping, then add embodiment 1-5 medicinal liquid and matched group respectively in hole, what matched group adopted is the good ointment of horse back on the market, is placed on observed result in calorstat.
Final result makes following form, observes embodiment to the bacteriostasis rate of different strains under the difference antibacterial time, thus can observe and obtain plant polypeptide compound gel and have good bacteriostatic activity.
Each embodiment is to the bacteriostasis rate (%) of different strains under the difference antibacterial time
bacteriostatic test example 6
Use plant polypeptide compound gel, and antibacterial gel yellow skin (main component: Radix Sophorae Flavescentis on the market, the Fructus Kochiae, Fructus Cnidii) to itch the three kind dominant bacteria (Malassezia furfurs of king to the clinical chlosma be separated with skin, sympodium chlosma, M.pachy dermats) carry out the research of antifungal activity in vitro, result shows that plant polypeptide compound gel has antifungic action to chlosma, the MIC value scope of plant polypeptide compound gel to chlosma is 625-20000 μ g/ml, the MIC meansigma methods of Malassezia furfur is starkly lower than sympodium and M.pachy dermats, and difference has statistical significance, illustrate that Malassezia furfur is more responsive to plant polypeptide compound gel, antibacterial ointment is got well at once and skin is itched, and king does not have inhibitory action to chlosma.This experiment card plant polypeptide compound gel has antifungic action to chlosma, and enriched the antifungal strain spectrum of plant polypeptide compound gel, further demonstrating plant polypeptide compound gel has the unexistent broad-spectrum antifungal of other antibacterial ointment on the market.
Claims (2)
1. an anti-inflammation external application Chinese medicine compound gel, it is characterized in that being made up by ratio of weight and the number of copies of following medicine:
Yang Tie blade root 10-18, Herba Violae 3-12, Radix Scutellariae 4-10, Flos Carthami 4-10, Fructus Cnidii 3-8, Rhizoma Atractylodis 2-6.
2. the preparation method of a kind of anti-inflammation external application Chinese medicine compound gel according to claim 1, comprises the following steps:
Take Yang Tie blade root, Herba Violae, Radix Scutellariae, Flos Carthami, Fructus Cnidii, Rhizoma Atractylodis in proportion, Chinese crude drug is put into reflux, in container, add Chinese medicine weight 10-20 water doubly, soak 1-3h, heating and refluxing extraction 1-3 time, merges each filtrate decocted, obtains Chinese medicine extraction liquid; Getting 2-10 part sodium carboxymethyl cellulose (viscosity is greater than 1200mPa.s) swells in extracting solution, spends the night; Get 2-5 part Borneolum Syntheticum to be dissolved in 3-10 part dehydrated alcohol, be prepared into Borneolum Syntheticum alcoholic solution; Get dodecyl sodium sulfate 2-5 part, glycerol 5-20 part, ethyl hydroxybenzoate 1-3 part, Borneolum Syntheticum alcoholic solution 3-10 part adds in Chinese medicine extraction liquid, high-speed stirred is even, gets product.
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| CN108578614A (en) * | 2018-05-17 | 2018-09-28 | 东莞市卫花生物科技有限公司 | A kind of draft nursing gel for having effects that sterilization and compacting |
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| CN107050256A (en) * | 2017-02-14 | 2017-08-18 | 哈尔滨市第医院 | Foot antimicrobial inflammation-relieving gel and preparation method thereof |
| CN108578614A (en) * | 2018-05-17 | 2018-09-28 | 东莞市卫花生物科技有限公司 | A kind of draft nursing gel for having effects that sterilization and compacting |
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