CN1246001C - 'Fufukang' Chinese traditional medicine preparation and preparing process thereof - Google Patents
'Fufukang' Chinese traditional medicine preparation and preparing process thereof Download PDFInfo
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- CN1246001C CN1246001C CN 200410021839 CN200410021839A CN1246001C CN 1246001 C CN1246001 C CN 1246001C CN 200410021839 CN200410021839 CN 200410021839 CN 200410021839 A CN200410021839 A CN 200410021839A CN 1246001 C CN1246001 C CN 1246001C
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- 239000003814 drug Substances 0.000 title claims abstract description 20
- 238000000034 method Methods 0.000 title abstract description 5
- 210000001215 vagina Anatomy 0.000 claims abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
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Abstract
The present invention relates to a 'Fufukang' Chinese traditional medicine preparation and a preparing process thereof, and the preparation is mainly prepared from creeping rostellularia herb and climbing groundsel; compared with the prior art, the present invention has effect on clearing away heat and toxic material, promoting blood circulation to stop pain and killing insects and relieving itching, and is used for treating colpitis mycotica, trichomonal vaginitis, bacteria vaginitis, vulvitis, pruritus of vagina, itch of skin, etc. The modern pharmacodynamics research proves that the present invention has good effect on phlogosis resistance, relieving itching and analgesia; a bacteriostasis experiment proves that the present invention has obvious bacteriostasis and sterilization effect on treating staphylococcus aureus, beta hemolytic streptococcus, pseudomonas aeruginosa, trichophyton rubrum, staphylococcus epidermidis, escherichia coli, neisseria gonorrhoeae, monilia albicans, novel cryptococcus neoformans, acrothesium floccosum, etc.
Description
Technical field: the present invention relates to a kind of Chinese medicine preparation for the treatment of the female vagina disease and preparation method thereof, belong to the field of traditional Chinese medicine technology.
Technical background: symptoms such as married woman's vaginal infection inflammation and pudendal pruritus, skin pruritus are commonly encountered diseases, frequently-occurring disease, often upset that the patient works normally, studying and living; Serious needs of patients is treated in hospital; Existing medicine has that JIEERYIN XIYE, woman's inflammation are clean, the scorching cream of woman or the like, and these medicines have certain therapeutical effect, but have certain problem: the one, and DeGrain, treatment time is long, or some curative effects are arranged, but curative effect is impermanent; The 2nd, their medicine constitutes more complicated, and the medical material that uses in the preparation process is too much, makes quality be difficult to be controlled better; Such present situation is difficult to satisfy demands of social development.
Summary of the invention: the objective of the invention is to: carry out deep development on square basis, a kind of Chinese medicine preparation for the treatment of the female vagina disease and preparation method thereof is provided at Guizhou Miao ethnic group regional experience; The present invention constitutes like this: calculate according to composition by weight: it is mainly by Herba Rostellulariae 80-180, and Herba Senecionis Scandentis 80-180 is prepared from specifically: it is by Herba Rostellulariae 120g, and Herba Senecionis Scandentis 80g is prepared from.Described preparation is a spray.Described preparation can also be: lotion, suppository, membrane, effervescent, tincture, lozenge, aerosol or oral tablet, capsule, soft capsule, granule, drop pill.Preparation method is: according to given ratio, medical material is made clear paste with ethanol precipitation after decocting in water extracts, be prepared into needed preparation then or medical material is got clear paste, is prepared into needed preparation then through alcohol extraction.Concrete method: get Herba Rostellulariae, after Herba Senecionis Scandentis two flavor medical materials add water retting 4-6 hour, decoct 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, gradation is filtered, and merging filtrate also is concentrated into relative density and surveys in the time of 70-80 ℃ and be the clear paste of 1.13-1.15, then, can suppress in flakes, fill becomes capsule, soft capsule, perhaps add sucrose and be prepared into granular preparation or drop pill.The preparation spray preparing process is: take by weighing Herba Rostellulariae 120g, Herba Senecionis Scandentis 80g, after adding water retting 4-6 hour, decoct 3 times 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, gradation was filtered, and merging filtrate also is concentrated into relative density and surveys in the time of 70-80 ℃ and be the clear paste of 1.13-1.15, put cold, add ethanol and make and contain the alcohol amount and reach 90%, left standstill 24 hours, filter, filtrate recycling ethanol is to there not being the alcohol flavor, add polyoxyethylene sorbitan monoleate 20g, add water to ormal weight again, stir evenly, filter, fill promptly gets the 1000ml external preparation, can further be prepared into spray, lotion, suppository, membrane, effervescent, aerosol, tincture, lozenge.
Compared with prior art: the present invention has heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, the worm itching relieving effect of stopping; Be used for treatment of conditions such as colpitis mycotica, trichomonal vaginitis, bacterial vaginitis, vulvitis and pruritus of vagina, skin pruritus; This product proves that through modern pharmacodynamic study antiinflammatory action is preferably arranged, itching-relieving action and analgesic activity.Prove through bacteriostatic test, this product is to staphylococcus aureus, beta hemolytic streptococcus, bacillus pyocyaneus, trichophyton, staphylococcus epidermidis, escherichia coli, Diplococcus gonorrhoeae, Candida albicans, Cryptococcus histolyticus, acrothesium floccosum etc. have significantly bacteriostasis or bactericidal action; Also have the anti-hook larva of a tapeworm or the cercaria of a schistosome and uncinarial dermatitis simultaneously, and the effect of anti-trichomonal.The side separates:
According to theoretical the returning of Miao ethnic group medicine through theory, medicine and disease are divided into cold and hot, the medicine of a warm nature is controlled cold disease, Gui Lengjing, cold medicine heats disease, returns hot warp.Married woman's vaginal infection disease, many genus infect unclean things, and long-pending for a long time how living damp and hot, damp and hot strongly fragrant in blood system, hemopoietic heat then further causes secondary infection again.Herba Rostellulariae in the prescription is the dry herb of acanthaceous plant Herba Rostellulariae.Be Guizhou Seedling doctor medical herbs commonly used, belong to cold medicine, has the disappear effect of stagnant, promoting blood circulation and stopping pain, Anti-Puritic and insecticidal of heat-clearing and toxic substances removing, dampness removing, it is intercalation to be usually used in cold, fever, laryngopharynx swelling and pain, infantile malnutrition etc., also be usually used in dermatitis, tinea pedis that the excrement poison causes, or pudendal pruritus due to unclean of vagina, erosion etc., but not only oral administration but also external.Herba Senecionis Scandentis is the dry aerial parts of feverfew Herba Senecionis Scandentis in the side, also is Seedling doctor conventional crude drugs.Belong to cold medicine, heat-clearing and toxic substances removing is arranged, the effect of eyesight-improving and pain-alleviating.Be usually used in anemopyretic cold, conjunctival congestion and swelling pain, dysentery, skin eczema, furuncle etc.This product is all gone into hot warp with the cold medicine phase 5 of two flavors, has then strengthened the merit of heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, killing parasites for relieving itching.Be applicable to colpitis mycotica, trichomonal vaginitis, bacterial vaginitis, vulvitis and skin pruritus etc.According to the theory of Chinese medical science analysis, this product is with heat-clearing and toxic substances removing, and dampness removing disappears stagnant, and the Herba Rostellulariae of promoting blood circulation and stopping pain, Anti-Puritic and insecticidal is monarch, is equipped with heat-clearing and toxic substances removing, makes eye bright, antipruritic Herba Senecionis Scandentis is minister, and both are 5 merits of playing heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, killing parasites for relieving itching altogether mutually.Infect so can be applicable to married woman's pudendum, due to inflammation and all diseases of pruritus.
The specific embodiment:
Embodiments of the invention 1: take by weighing Herba Rostellulariae 120g, Herba Senecionis Scandentis 80g, after adding water retting 4-6 hour, decoct 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, gradation is filtered, and merging filtrate also is concentrated into relative density and surveys in the time of 70-80 ℃ and be the clear paste of 1.13-1.15, puts cold, adding ethanol makes and contains the alcohol amount and reach 90%, left standstill 24 hours, and filtered, filtrate recycling ethanol is to there not being the alcohol flavor, add polyoxyethylene sorbitan monoleate 20g, add water to ormal weight again, stir evenly, filter, fill promptly gets the 1000ml spray.The product trade name of present embodiment production is: " Fufukang spray ".Be sprayed directly on to the patient affected part during use.
Embodiments of the invention 2: according to given ratio, with medical material Herba Rostellulariae 80kg, Herba Senecionis Scandentis 80kg makes clear paste with ethanol precipitation after decocting in water extracts, and then, adds the starch compacting in flakes.During use three times on the oral one, each two.
Embodiments of the invention 3: get Herba Rostellulariae 180g, Herba Senecionis Scandentis 180g added water retting after 4 hours, decocted three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, gradation is filtered, and merging filtrate also is concentrated into relative density and surveys in the time of 70-80 ℃ and be the clear paste of 1.13-1.15, then, put coldly, add ethanol and make and contain the alcohol amount and reach 90%, left standstill 24 hours, filter, filtrate recycling ethanol adds polyoxyethylene sorbitan monoleate 20g to there not being the alcohol flavor, add water to ormal weight again, stir evenly, filter, further be prepared into lotion.
Embodiments of the invention 4: it is by Herba Rostellulariae 150g, and Herba Senecionis Scandentis 150g is prepared from.Medical material is made clear paste after decocting in water extracts, add sucrose then and be prepared into granular preparation.Embodiments of the invention 5: it is by Herba Rostellulariae 100g, and Herba Senecionis Scandentis 80g is prepared from.Get Herba Rostellulariae, Herba Senecionis Scandentis two flavor medical materials added water retting after 6 hours, decoct 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, gradation is filtered, merging filtrate also is concentrated into relative density and surveys in the time of 70-80 ℃ and be the clear paste of 1.13-1.15, then, adds ethanol and makes and contain the alcohol amount and reach 90%, left standstill 24 hours, filter, filtrate recycling ethanol adds polyoxyethylene sorbitan monoleate 20g to there not being the alcohol flavor, add water to ormal weight again, stir evenly, filter, fill promptly gets the 1000ml external preparation, can further prepare membrane.In actual development process, the inventor finds: this prescription serves as basis side with Herba Rostellulariae, Herba Senecionis Scandentis, has heat-clearing and toxic substances removing if add the 1-2 flavor, blood circulation promoting and blood stasis dispelling, pain relieving, the prescription of the Chinese herbal medicine combination of killing parasites for relieving itching class; As add Herba Hedyotidis Diffusae, Radix Salviae Miltiorrhizae, Radix Zanthoxyli, Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Fructus Cnidii, Herba Saxifragae, the Radix Stemonae, Rhizoma Curcumae, Cortex Phellodendri etc. have the treatment gynecological diseases medical material in simply or combination in any two the flavor medical materials all do not influence effect of the present invention and have certain auxiliary curative effect.
Clinical efficacy:
This product is through Guangzhou General Hospital Guangzhou Military Command's department of obstetrics and gynecology, gynecological of Guangzhou Medical College Annex II institute, gynecological of Guangdong Women and Children's Hospital and Health Insitute, three tame hospitals in October, 2000 to December, treatment vulvitis, nonspecific vaginitis, colpitis mycotica, trichomonal vaginitis, senile vaginitis, each 30 example is respectively established matched group 20 examples, with the JIEERYIN contrast, its result is:
Total is accepted 750 examples for medical treatment, and 450 examples are organized in treatment, clinical recovery example, produce effects 146 examples, effective 102 examples, invalid 41 examples, total effective rate are 90.9%, and are invalid 9.1%, and matched group is totally 300 examples, clinical recovery 69 examples, produce effects 78 examples, invalid 90 examples of effective 63 examples, total effective rate 70%, invalid 30%.
Through Ridit check, be criterion group with the matched group, R value=0.5, treatment group R value 0.629,95% is credible to be limited to 0.613～0.655, does not contain 0.5, and P＜0.05 then is so there were significant differences points out treatment group curative effect obviously to be better than matched group for treatment group and matched group comparison.See table 1 and table 2 for details.
Table 1 treatment group and matched group portion efficacy analysis
| Classification of diseases | Group | The example number | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate | The P value | |||||
| ％ | Example | ％ | Example | ％ | Example | ％ | Example | ％ | |||||
| Nonspecific vaginitis trichomonas vaginitis colpomycosis senile vahinitis vulvitis | Treatment group treatment of control group group treatment of control group group treatment of control group group treatment of control group group control group | 90 60 90 60 90 60 90 60 90 60 | 35 11 34 15 26 13 33 13 33 17 | 38.9 18.3 37.8 25 28.9 21.7 36.7 21.7 36.7 28.3 | 212 19 28 16 38 16 27 14 32 13 | 23.3 31.7 31.1 26.7 42.2 26.7 30 23.3 35.6 21.7 | 27 9 23 9 21 16 14 15 17 14 | 30 15 25.6 15 23.3 26.7 15.6 25 18.9 23.3 | 7 21 5 20 5 15 16 18 8 16 | 7.8 35 5.6 33.3 5.6 25 17.8 30 8.9 26.7 | 83 39 85 40 85 45 74 42 82 44 | 92.2 65.0 94.4 66.7 94.4 75.0 82.2 70.0 91.1 73.3 | ＜0.05 ＜0.05 ＜0.05 ＜0.05 ＜0.05 |
Table 2 treatment group and matched group total effects are relatively
| Group n | Example number (%) | |||||
| Recovery from illness | Produce effects | Effectively | Invalid | Cure rate | Total effective rate | |
| 450 161 matched groups 300 69 are organized in treatment | (35.77) (23.00) | 146 (32.44) 78 (26.00) | 102 (22.66) 63 (21.00) | 41 (9.12) 90 (30.00) | 207 (90.88) 147 (49.00) | 409 (90.88) 210 (70.00) |
| The Ridit check, R=0.629,95%cl:0.613～0.655 does not contain 0.5, P＜0.05. | ||||||
Claims (7)
1, a kind of Chinese medicine preparation for the treatment of the female vagina disease is characterized in that: according to listed as parts by weight: it is mainly by Herba Rostellulariae 80-180, and Herba Senecionis Scandentis 80-180 is prepared from.
2, according to the Chinese medicine preparation of the described treatment female vagina of claim 1 disease, it is characterized in that: it is by Herba Rostellulariae 120g, and Herba Senecionis Scandentis 80g is prepared from.
3, according to the Chinese medicine preparation of claim 1 or 2 described treatment female vagina diseases, it is characterized in that: described preparation is a spray.
4, according to the Chinese medicine preparation of claim 1 or 2 described treatment female vagina diseases, it is characterized in that: described preparation is: lotion, suppository, membrane, effervescent, aerosol, tincture, lozenge or oral tablet, capsule, soft capsule, granule, drop pill.
5, as the preparation method of the Chinese medicine preparation of right 1 or 2 described treatment female vagina diseases, it is characterized in that: according to given ratio, medical material is made clear paste with ethanol precipitation after decocting in water extracts, be prepared into needed preparation then or medical material is got clear paste, is prepared into needed preparation then through alcohol extraction.
6, according to the preparation method of the Chinese medicine preparation of the described treatment female vagina of claim 5 disease, it is characterized in that: above two the flavor medical materials, add water retting 4-6 hour after, decoct 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, gradation was filtered, merging filtrate also is concentrated into relative density and surveys in the time of 70-80 ℃ and be the clear paste of 1.13-1.15, then, compacting is in blocks, fill becomes capsule, soft capsule, perhaps adds sucrose and is prepared into granular preparation or drop pill.
7, preparation method according to the Chinese medicine preparation of the described treatment female vagina of claim 5 disease, it is characterized in that: take by weighing Herba Rostellulariae 120g, Herba Senecionis Scandentis 80g, after adding water retting 4-6 hour, decoct 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, gradation is filtered, merging filtrate also is concentrated into relative density and surveys in the time of 70-80 ℃ and be the clear paste of 1.13-1.15, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 90%, left standstill 24 hours, filter, filtrate recycling ethanol adds polyoxyethylene sorbitan monoleate 20g to there not being the alcohol flavor, add water to ormal weight again, stir evenly, filter, fill promptly gets the 1000ml external preparation, is prepared into spray, lotion, suppository, membrane, effervescent, aerosol, tincture, lozenge.
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| CN 200410021839 CN1246001C (en) | 2004-02-13 | 2004-02-13 | 'Fufukang' Chinese traditional medicine preparation and preparing process thereof |
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| CN102008531B (en) * | 2010-12-06 | 2013-03-20 | 贵州荣发制药有限责任公司 | Fufukang gel and preparation method thereof |
| CN102743612B (en) * | 2012-06-17 | 2013-12-11 | 姚丽娟 | Preparation method of Chinese medicine irrigation solution for treating bean curd broken bits type mycotic vaginitis |
| CN103127312A (en) * | 2013-03-19 | 2013-06-05 | 迟仁智 | External Antiviral and anti-pathogenic gynecological lotion and preparation technology |
| CN105116081A (en) * | 2015-04-20 | 2015-12-02 | 贵阳德昌祥药业有限公司 | Detection method for heat-clearing and stasis-removing drugs |
| CN105362487A (en) * | 2015-12-12 | 2016-03-02 | 倪朝洪 | Traditional Chinese medicine composition for treating vaginitis |
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